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Conserved domains on  [gi|1343071478|ref|NP_001071095|]
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interferon gamma receptor 2 precursor [Danio rerio]

Protein Classification

FN3 domain-containing protein( domain architecture ID 10637270)

FN3 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 24-96 7.30e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


:

Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 40.68  E-value: 7.30e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071478   24 PPQDLKIVKS-----QLLWKPPEVDEDLRYSLQYKL-DSKAEDKWYNVSSHINKNVFNITDEFYGAL--FRVRAEKGNHI 95
Cdd:smart00060   3 PPSNLRVTDVtstsvTLSWEPPPDDGITGYIVGYRVeYREEGSEWKEVNVTPSSTSYTLTGLKPGTEyeFRVRAVNGAGE 82


                   .
gi 1343071478   96 S 96
Cdd:smart00060  83 G 83
Interfer-bind super family cl46366
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 135-206 2.61e-04

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


The actual alignment was detected with superfamily member pfam09294:

Pssm-ID: 480706  Cd Length: 103  Bit Score: 39.63  E-value: 2.61e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1343071478 135 SLEKEHGeHLEFNISSWsvNSRENPEEDVVINSKD-YIFNDLESGQIYCFQVE--YLLYHKPYGKaSKERCVFIP 206
Cdd:pfam09294  33 SLRDLYG-SLQYRVSYW--KNSSNGEKKNTTSTNSfVVLSDLEPGTTYCVSVQafSPLDNKSSQR-SPPQCIRTT 103
 
Name Accession Description Interval E-value
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 24-96 7.30e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 40.68  E-value: 7.30e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071478   24 PPQDLKIVKS-----QLLWKPPEVDEDLRYSLQYKL-DSKAEDKWYNVSSHINKNVFNITDEFYGAL--FRVRAEKGNHI 95
Cdd:smart00060   3 PPSNLRVTDVtstsvTLSWEPPPDDGITGYIVGYRVeYREEGSEWKEVNVTPSSTSYTLTGLKPGTEyeFRVRAVNGAGE 82


                   .
gi 1343071478   96 S 96
Cdd:smart00060  83 G 83
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 135-206 2.61e-04

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


Pssm-ID: 462746  Cd Length: 103  Bit Score: 39.63  E-value: 2.61e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1343071478 135 SLEKEHGeHLEFNISSWsvNSRENPEEDVVINSKD-YIFNDLESGQIYCFQVE--YLLYHKPYGKaSKERCVFIP 206
Cdd:pfam09294  33 SLRDLYG-SLQYRVSYW--KNSSNGEKKNTTSTNSfVVLSDLEPGTTYCVSVQafSPLDNKSSQR-SPPQCIRTT 103
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 7-98 3.46e-04

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


Pssm-ID: 460067  Cd Length: 107  Bit Score: 39.29  E-value: 3.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071478   7 LTVFMLIVNIErTCC---LNPPQDLKI----VKSQLLWKPPEVD-EDLRYSLQYKldSKAEDKWYNVsshinKNVFNITD 78
Cdd:pfam01108   5 LLGLLLLALAS-AAGgpsLPAPQNVTFqstnFKNILTWEPGPNSpPDVVYTVQYK--IYGSGDWKNV-----PNCTNITR 76

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1343071478  79 EF-----------YGALFRVRAEKGNHISEW 98
Cdd:pfam01108  77 TEcdltdetsdltETYYARVRAVSGGGTSSW 107
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 23-101 6.39e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 38.25  E-value: 6.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071478  23 NPPQDLKIVKS-----QLLWKPPEVD--EDLRYSLQYKldSKAEDKWYNVSSH-INKNVFNITD----EFYgaLFRVRAE 90
Cdd:cd00063     2 SPPTNLRVTDVtstsvTLSWTPPEDDggPITGYVVEYR--EKGSGDWKEVEVTpGSETSYTLTGlkpgTEY--EFRVRAV 77

                          90
                  ....*....|.
gi 1343071478  91 KGNHISEWAIS 101
Cdd:cd00063    78 NGGGESPPSES 88
 
Name Accession Description Interval E-value
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 24-96 7.30e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 40.68  E-value: 7.30e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071478   24 PPQDLKIVKS-----QLLWKPPEVDEDLRYSLQYKL-DSKAEDKWYNVSSHINKNVFNITDEFYGAL--FRVRAEKGNHI 95
Cdd:smart00060   3 PPSNLRVTDVtstsvTLSWEPPPDDGITGYIVGYRVeYREEGSEWKEVNVTPSSTSYTLTGLKPGTEyeFRVRAVNGAGE 82


                   .
gi 1343071478   96 S 96
Cdd:smart00060  83 G 83
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 135-206 2.61e-04

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


Pssm-ID: 462746  Cd Length: 103  Bit Score: 39.63  E-value: 2.61e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1343071478 135 SLEKEHGeHLEFNISSWsvNSRENPEEDVVINSKD-YIFNDLESGQIYCFQVE--YLLYHKPYGKaSKERCVFIP 206
Cdd:pfam09294  33 SLRDLYG-SLQYRVSYW--KNSSNGEKKNTTSTNSfVVLSDLEPGTTYCVSVQafSPLDNKSSQR-SPPQCIRTT 103
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 7-98 3.46e-04

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


Pssm-ID: 460067  Cd Length: 107  Bit Score: 39.29  E-value: 3.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071478   7 LTVFMLIVNIErTCC---LNPPQDLKI----VKSQLLWKPPEVD-EDLRYSLQYKldSKAEDKWYNVsshinKNVFNITD 78
Cdd:pfam01108   5 LLGLLLLALAS-AAGgpsLPAPQNVTFqstnFKNILTWEPGPNSpPDVVYTVQYK--IYGSGDWKNV-----PNCTNITR 76

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1343071478  79 EF-----------YGALFRVRAEKGNHISEW 98
Cdd:pfam01108  77 TEcdltdetsdltETYYARVRAVSGGGTSSW 107
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 23-101 6.39e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 38.25  E-value: 6.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071478  23 NPPQDLKIVKS-----QLLWKPPEVD--EDLRYSLQYKldSKAEDKWYNVSSH-INKNVFNITD----EFYgaLFRVRAE 90
Cdd:cd00063     2 SPPTNLRVTDVtstsvTLSWTPPEDDggPITGYVVEYR--EKGSGDWKEVEVTpGSETSYTLTGlkpgTEY--EFRVRAV 77

                          90
                  ....*....|.
gi 1343071478  91 KGNHISEWAIS 101
Cdd:cd00063    78 NGGGESPPSES 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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