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Conserved domains on  [gi|119220550|ref|NP_001073121|]
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protein sidekick-1 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
9-393 1.39e-18

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 90.06  E-value: 1.39e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119220550   9 GEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLqdVPGEPPGSVSATPHTTSSVLIQWQP 88
Cdd:COG3401  178 AAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPT--TPPSAPTGLTATADTPGSVTLSWDP 255

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119220550  89 PRDESlnglLQGYRIYYREleyeagsgteaktlknpialhaelTAQSSFKTVNSSSTS--TMCELTHLKKYrRYEVimTA 166
Cdd:COG3401  256 VTESD----ATGYRVYRSN------------------------SGDGPFTKVATVTTTsyTDTGLTNGTTY-YYRV--TA 304

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119220550 167 YNIIG-ESPASAPVEVFVGEAAPAmAPQNVQVTPLTASQLEVTWDPpppeSQNGNIQGYKIYYWEADSQNETEKMKVlfL 245
Cdd:COG3401  305 VDAAGnESAPSNVVSVTTDLTPPA-APSGLTATAVGSSSITLSWTA----SSDADVTGYNVYRSTSGGGTYTKIAET--V 377

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119220550 246 PEPVVRLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEPAAANGILQGYRVV 325
Cdd:COG3401  378 TTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAV 457

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 119220550 326 YEPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQARTITYGPELQANITAGPAEGSPGSP 393
Cdd:COG3401  458 LADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPD 525
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 390-483 9.61e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 72.91  E-value: 9.61e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119220550 390 PGSPRDVLVTK-SASELTLQWTEGHSGDTPTTGYVIEARPSDEGLWdMFVKDIPRSATSYTLslDKLRQGVTYEFRVVAV 468
Cdd:cd00063    1 PSPPTNLRVTDvTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDW-KEVEVTPGSETSYTL--TGLKPGTEYEFRVRAV 77

                         90
                 ....*....|....*
gi 119220550 469 NEAGYGEPSNPSTAV 483
Cdd:cd00063   78 NGGGESPPSESVTVT 92
 
Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
9-393 1.39e-18

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 90.06  E-value: 1.39e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119220550   9 GEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLqdVPGEPPGSVSATPHTTSSVLIQWQP 88
Cdd:COG3401  178 AAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPT--TPPSAPTGLTATADTPGSVTLSWDP 255

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119220550  89 PRDESlnglLQGYRIYYREleyeagsgteaktlknpialhaelTAQSSFKTVNSSSTS--TMCELTHLKKYrRYEVimTA 166
Cdd:COG3401  256 VTESD----ATGYRVYRSN------------------------SGDGPFTKVATVTTTsyTDTGLTNGTTY-YYRV--TA 304

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119220550 167 YNIIG-ESPASAPVEVFVGEAAPAmAPQNVQVTPLTASQLEVTWDPpppeSQNGNIQGYKIYYWEADSQNETEKMKVlfL 245
Cdd:COG3401  305 VDAAGnESAPSNVVSVTTDLTPPA-APSGLTATAVGSSSITLSWTA----SSDADVTGYNVYRSTSGGGTYTKIAET--V 377

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119220550 246 PEPVVRLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEPAAANGILQGYRVV 325
Cdd:COG3401  378 TTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAV 457

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 119220550 326 YEPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQARTITYGPELQANITAGPAEGSPGSP 393
Cdd:COG3401  458 LADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPD 525
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 191-284 4.17e-18

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 79.85  E-value: 4.17e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119220550 191 APQNVQVTPLTASQLEVTWDPPPPEsqNGNIQGYKIYYWEADSqNETEKMKVLFLPEPVVRLKNLTSHTKYLVSISAFNA 270
Cdd:cd00063    3 PPTNLRVTDVTSTSVTLSWTPPEDD--GGPITGYVVEYREKGS-GDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                         90
                 ....*....|....
gi 119220550 271 AGDGPKSDPQQGRT 284
Cdd:cd00063   80 GGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
191-277 1.27e-16

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 75.14  E-value: 1.27e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119220550  191 APQNVQVTPLTASQLEVTWDPPPPesQNGNIQGYKIYYWEADSqNETEKMKVLFLPEPVVRLKNLTSHTKYLVSISAFNA 270
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSWTPPPD--GNGPITGYEVEYRPKNS-GEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                  ....*..
gi 119220550  271 AGDGPKS 277
Cdd:pfam00041  79 GGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 390-483 9.61e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 72.91  E-value: 9.61e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119220550 390 PGSPRDVLVTK-SASELTLQWTEGHSGDTPTTGYVIEARPSDEGLWdMFVKDIPRSATSYTLslDKLRQGVTYEFRVVAV 468
Cdd:cd00063    1 PSPPTNLRVTDvTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDW-KEVEVTPGSETSYTL--TGLKPGTEYEFRVRAV 77

                         90
                 ....*....|....*
gi 119220550 469 NEAGYGEPSNPSTAV 483
Cdd:cd00063   78 NGGGESPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 191-274 1.55e-14

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 69.18  E-value: 1.55e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119220550   191 APQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVlflPEPVVRLKNLTSHTKYLVSISAFNA 270
Cdd:smart00060   3 PPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTP---SSTSYTLTGLKPGTEYEFRVRAVNG 79


                   ....
gi 119220550   271 AGDG 274
Cdd:smart00060  80 AGEG 83
fn3 pfam00041
Fibronectin type III domain;
391-477 2.49e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 68.60  E-value: 2.49e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119220550  391 GSPRDVLVT-KSASELTLQWTEGHSGDTPTTGYVIEARPSDEGlWDMFVKDIPRSATSYTLSldKLRQGVTYEFRVVAVN 469
Cdd:pfam00041   1 SAPSNLTVTdVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSG-EPWNEITVPGTTTSVTLT--GLKPGTEYEVRVQAVN 77


                  ....*...
gi 119220550  470 EAGYGEPS 477
Cdd:pfam00041  78 GGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 390-474 2.14e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.54  E-value: 2.14e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119220550   390 PGSPRDVLVTK-SASELTLQWT--EGHSGDTPTTGYVIEARPSDEGlwdmfVKDIPRSATSYTLSLDKLRQGVTYEFRVV 466
Cdd:smart00060   1 PSPPSNLRVTDvTSTSVTLSWEppPDDGITGYIVGYRVEYREEGSE-----WKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75


                   ....*...
gi 119220550   467 AVNEAGYG 474
Cdd:smart00060  76 AVNGAGEG 83
 
Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
9-393 1.39e-18

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 90.06  E-value: 1.39e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119220550   9 GEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLqdVPGEPPGSVSATPHTTSSVLIQWQP 88
Cdd:COG3401  178 AAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPT--TPPSAPTGLTATADTPGSVTLSWDP 255

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119220550  89 PRDESlnglLQGYRIYYREleyeagsgteaktlknpialhaelTAQSSFKTVNSSSTS--TMCELTHLKKYrRYEVimTA 166
Cdd:COG3401  256 VTESD----ATGYRVYRSN------------------------SGDGPFTKVATVTTTsyTDTGLTNGTTY-YYRV--TA 304

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119220550 167 YNIIG-ESPASAPVEVFVGEAAPAmAPQNVQVTPLTASQLEVTWDPpppeSQNGNIQGYKIYYWEADSQNETEKMKVlfL 245
Cdd:COG3401  305 VDAAGnESAPSNVVSVTTDLTPPA-APSGLTATAVGSSSITLSWTA----SSDADVTGYNVYRSTSGGGTYTKIAET--V 377

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119220550 246 PEPVVRLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEPAAANGILQGYRVV 325
Cdd:COG3401  378 TTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAV 457

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 119220550 326 YEPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQARTITYGPELQANITAGPAEGSPGSP 393
Cdd:COG3401  458 LADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPD 525
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 191-284 4.17e-18

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 79.85  E-value: 4.17e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119220550 191 APQNVQVTPLTASQLEVTWDPPPPEsqNGNIQGYKIYYWEADSqNETEKMKVLFLPEPVVRLKNLTSHTKYLVSISAFNA 270
Cdd:cd00063    3 PPTNLRVTDVTSTSVTLSWTPPEDD--GGPITGYVVEYREKGS-GDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                         90
                 ....*....|....
gi 119220550 271 AGDGPKSDPQQGRT 284
Cdd:cd00063   80 GGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
191-277 1.27e-16

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 75.14  E-value: 1.27e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119220550  191 APQNVQVTPLTASQLEVTWDPPPPesQNGNIQGYKIYYWEADSqNETEKMKVLFLPEPVVRLKNLTSHTKYLVSISAFNA 270
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSWTPPPD--GNGPITGYEVEYRPKNS-GEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                  ....*..
gi 119220550  271 AGDGPKS 277
Cdd:pfam00041  79 GGEGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
259-487 2.02e-16

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 83.13  E-value: 2.02e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119220550 259 TKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWgEPAAANGiLQGYRV--------VYEPLA 330
Cdd:COG3401  203 TTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSW-DPVTESD-ATGYRVyrsnsgdgPFTKVA 280

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119220550 331 PVQGVSKVVTvevrgnwqrwlkvrDLTKGVTYFFRVQARTITYGPELQANI-TAGPAEGSPGSPRDVLVT-KSASELTLQ 408
Cdd:COG3401  281 TVTTTSYTDT--------------GLTNGTTYYYRVTAVDAAGNESAPSNVvSVTTDLTPPAAPSGLTATaVGSSSITLS 346

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119220550 409 WTEghSGDTPTTGYVIEARPSDEGLWDmfvkDIPRSATSYTLSLDKLRQGVTYEFRVVAVNEAG-YGEPSNPSTAVSAQV 487
Cdd:COG3401  347 WTA--SSDADVTGYNVYRSTSGGGTYT----KIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASA 420
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 390-483 9.61e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 72.91  E-value: 9.61e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119220550 390 PGSPRDVLVTK-SASELTLQWTEGHSGDTPTTGYVIEARPSDEGLWdMFVKDIPRSATSYTLslDKLRQGVTYEFRVVAV 468
Cdd:cd00063    1 PSPPTNLRVTDvTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDW-KEVEVTPGSETSYTL--TGLKPGTEYEFRVRAV 77

                         90
                 ....*....|....*
gi 119220550 469 NEAGYGEPSNPSTAV 483
Cdd:cd00063   78 NGGGESPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 191-274 1.55e-14

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 69.18  E-value: 1.55e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119220550   191 APQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVlflPEPVVRLKNLTSHTKYLVSISAFNA 270
Cdd:smart00060   3 PPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTP---SSTSYTLTGLKPGTEYEFRVRAVNG 79


                   ....
gi 119220550   271 AGDG 274
Cdd:smart00060  80 AGEG 83
fn3 pfam00041
Fibronectin type III domain;
391-477 2.49e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 68.60  E-value: 2.49e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119220550  391 GSPRDVLVT-KSASELTLQWTEGHSGDTPTTGYVIEARPSDEGlWDMFVKDIPRSATSYTLSldKLRQGVTYEFRVVAVN 469
Cdd:pfam00041   1 SAPSNLTVTdVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSG-EPWNEITVPGTTTSVTLT--GLKPGTEYEVRVQAVN 77


                  ....*...
gi 119220550  470 EAGYGEPS 477
Cdd:pfam00041  78 GGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 289-370 1.30e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.05  E-value: 1.30e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119220550 289 PGAPSFLAFSEITSTTLNVSWGEPAAANGILQGYRVVYEPLapvqGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQA 368
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREK----GSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRA 76


                 ..
gi 119220550 369 RT 370
Cdd:cd00063   77 VN 78
fn3 pfam00041
Fibronectin type III domain;
290-376 1.71e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.51  E-value: 1.71e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119220550  290 GAPSFLAFSEITSTTLNVSWGEPAAANGILQGYRVVYEplaPVQGVSKVVTVEVRGNwQRWLKVRDLTKGVTYFFRVQAR 369
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYR---PKNSGEPWNEITVPGT-TTSVTLTGLKPGTEYEVRVQAV 76


                  ....*...
gi 119220550  370 T-ITYGPE 376
Cdd:pfam00041  77 NgGGEGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 67-181 2.25e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.59  E-value: 2.25e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119220550  67 EPPGSVSATPHTTSSVLIQWQPPRDEslNGLLQGYRIYYREleyeagsgteaktlknpialhaelTAQSSFKTVNS-SST 145
Cdd:cd00063    2 SPPTNLRVTDVTSTSVTLSWTPPEDD--GGPITGYVVEYRE------------------------KGSGDWKEVEVtPGS 55

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 119220550 146 STMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEV 181
Cdd:cd00063   56 ETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTV 91
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 289-370 1.13e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 55.31  E-value: 1.13e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119220550   289 PGAPSFLAFSEITSTTLNVSWGEPAAANGIlqGYRVVYEpLAPVQGVSKVVTVEVRGNwQRWLKVRDLTKGVTYFFRVQA 368
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGIT--GYIVGYR-VEYREEGSEWKEVNVTPS-STSYTLTGLKPGTEYEFRVRA 76


                   ..
gi 119220550   369 RT 370
Cdd:smart00060  77 VN 78
fn3 pfam00041
Fibronectin type III domain;
68-176 1.54e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.11  E-value: 1.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119220550   68 PPGSVSATPHTTSSVLIQWQPPRDesLNGLLQGYRIYYRELeyeagsgteaktlknpialhaelTAQSSFKTVNSSSTST 147
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSWTPPPD--GNGPITGYEVEYRPK-----------------------NSGEPWNEITVPGTTT 56

                          90       100
                  ....*....|....*....|....*....
gi 119220550  148 MCELTHLKKYRRYEVIMTAYNIIGESPAS 176
Cdd:pfam00041  57 SVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 68-173 1.78e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.93  E-value: 1.78e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119220550    68 PPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEyeagsgteaktlknpialhaeltaqSSFKTVNSSSTST 147
Cdd:smart00060   3 PPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEG-------------------------SEWKEVNVTPSST 57

                           90       100
                   ....*....|....*....|....*.
gi 119220550   148 MCELTHLKKYRRYEVIMTAYNIIGES 173
Cdd:smart00060  58 SYTLTGLKPGTEYEFRVRAVNGAGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 390-474 2.14e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.54  E-value: 2.14e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119220550   390 PGSPRDVLVTK-SASELTLQWT--EGHSGDTPTTGYVIEARPSDEGlwdmfVKDIPRSATSYTLSLDKLRQGVTYEFRVV 466
Cdd:smart00060   1 PSPPSNLRVTDvTSTSVTLSWEppPDDGITGYIVGYRVEYREEGSE-----WKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75


                   ....*...
gi 119220550   467 AVNEAGYG 474
Cdd:smart00060  76 AVNGAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2-59 1.39e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 46.72  E-value: 1.39e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 119220550   2 QVRELPRGEWQTYSSSISHEaTACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVT 59
Cdd:cd00063   37 EYREKGSGDWKEVEVTPGSE-TSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
159-502 6.79e-04

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 43.01  E-value: 6.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119220550 159 RYEVIMTAYN-----------IIGESPASAPVEVFVGEAApamapqNVQVTPLTASQLEVTWDPPPPESqngniqGYKIy 227
Cdd:COG4733  503 TYTITAVQHApekyaaidagaFDDVPPQWPPVNVTTSESL------SVVAQGTAVTTLTVSWDAPAGAV------AYEV- 569

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119220550 228 YWEADSQNETEKMKVlflPEPVVRLKNLTSHTkYLVSISAFNAAGDgpKSDPQQGRTHQ-----AAPGAP-SFLAFSEIT 301
Cdd:COG4733  570 EWRRDDGNWVSVPRT---SGTSFEVPGIYAGD-YEVRVRAINALGV--SSAWAASSETTvtgktAPPPAPtGLTATGGLG 643

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119220550 302 STTLNvsWGEPAAANgiLQGYRVVYEPlAPVQGVSKVVTVEVRGNwqRWLKVrDLTKGVTYFFRVQARTiTYGPELQANI 381
Cdd:COG4733  644 GITLS--WSFPVDAD--TLRTEIRYST-TGDWASATVAQALYPGN--TYTLA-GLKAGQTYYYRARAVD-RSGNVSAWWV 714

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119220550 382 TAGPAEGSPGSPRDVLVTKSASELT--LQWTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSATSYTLSLDKLRQGV 459
Cdd:COG4733  715 SGQASADAAGILDAITGQILETELGqeLDAIIQNATVAEVVAATVTDVTAQIDTAVLFAGVATAAAIGAEARVAATVAES 794

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 119220550 460 TYEFRVVAVNEAGYGEPSNPSTAVSAQVEAPFYEEWWFLLVMA 502
Cdd:COG4733  795 ATAAAATGTAADAAGDASGGVTAGTSGTTGAGDTAASTTRVAA 837
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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