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Conserved domains on  [gi|122937259|ref|NP_001073900|]
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solute carrier family 45 member 4 isoform 2 [Homo sapiens]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 15-219 1.63e-64

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17313:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 421  Bit Score: 221.73  E-value: 1.63e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259  15 TLVSPLrsnqwsLQK-GLPEQYYSLTWFLSPILGLIFTPLIGSASDRCTLSWGRRRPFILALCVGVLFGVALFLNGSAIG 93
Cdd:cd17313   20 SYVPPI------LQTlGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCNSRIGRRRPFILVGAPLAALGLILIPNAADIG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259  94 LALGDvpNRQPIGIVLTVLGVVVLDFSADATEGPIRAYLLDVVDSEEQDMALNIHAFSAGLGGAIGYVLGGLDWTQTFLG 173
Cdd:cd17313   94 LALGD--GPRTWALVLFVLGIVLLDFAMNVCQGPVRALLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGAILWDHNWFG 171

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 122937259 174 SWFRTQNQVLFFFAAIIFTVSVALHLFSIDEEQYSPQQERSAEEPG 219
Cdd:cd17313  172 FALGGNLKVPFYIGAIILLVCVLVTLFFVKEPPLSPEAGEHSENPS 217
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 446-658 3.60e-54

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17313:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 421  Bit Score: 193.23  E-value: 3.60e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259 446 LWLSMLKMPRELMRLCLCHLLTWFSVIAEAVFYTDFMGQVIFEGdpkapsNSTAWQAYNAGVKMGCWGLVIYAATGAICS 525
Cdd:cd17313  225 LLKLLKIMPRSLLRLLLVIFFWWIAFFPFELFFTDYMGEEVYHG------TSAASSHYGAGVRMGAWGLLIFSLAFLIFS 298

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259 526 ALLQKYLDNYdlSVRVIYVLGTLGFSVGTAVMAMFPNVYVAMVTISTMGIVSMSISYCPYALLGQYHDikqyihhspgNS 605
Cdd:cd17313  299 LPIGKLGKKI--GRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININPYPLVSDYHS----------ES 366

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 122937259 606 KRGFGIDCAILSCQVYISQILVASALGGV--VDAVGTVRVIPMVASVGSFLGFLT 658
Cdd:cd17313  367 GRGQGTDTGLLNLAISLAQILVSLLAGPIidVKGYGTVFPVAAVASFLSLVGALF 421
 
Name Accession Description Interval E-value
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 15-219 1.63e-64

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 221.73  E-value: 1.63e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259  15 TLVSPLrsnqwsLQK-GLPEQYYSLTWFLSPILGLIFTPLIGSASDRCTLSWGRRRPFILALCVGVLFGVALFLNGSAIG 93
Cdd:cd17313   20 SYVPPI------LQTlGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCNSRIGRRRPFILVGAPLAALGLILIPNAADIG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259  94 LALGDvpNRQPIGIVLTVLGVVVLDFSADATEGPIRAYLLDVVDSEEQDMALNIHAFSAGLGGAIGYVLGGLDWTQTFLG 173
Cdd:cd17313   94 LALGD--GPRTWALVLFVLGIVLLDFAMNVCQGPVRALLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGAILWDHNWFG 171

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 122937259 174 SWFRTQNQVLFFFAAIIFTVSVALHLFSIDEEQYSPQQERSAEEPG 219
Cdd:cd17313  172 FALGGNLKVPFYIGAIILLVCVLVTLFFVKEPPLSPEAGEHSENPS 217
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 446-658 3.60e-54

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 193.23  E-value: 3.60e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259 446 LWLSMLKMPRELMRLCLCHLLTWFSVIAEAVFYTDFMGQVIFEGdpkapsNSTAWQAYNAGVKMGCWGLVIYAATGAICS 525
Cdd:cd17313  225 LLKLLKIMPRSLLRLLLVIFFWWIAFFPFELFFTDYMGEEVYHG------TSAASSHYGAGVRMGAWGLLIFSLAFLIFS 298

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259 526 ALLQKYLDNYdlSVRVIYVLGTLGFSVGTAVMAMFPNVYVAMVTISTMGIVSMSISYCPYALLGQYHDikqyihhspgNS 605
Cdd:cd17313  299 LPIGKLGKKI--GRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININPYPLVSDYHS----------ES 366

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 122937259 606 KRGFGIDCAILSCQVYISQILVASALGGV--VDAVGTVRVIPMVASVGSFLGFLT 658
Cdd:cd17313  367 GRGQGTDTGLLNLAISLAQILVSLLAGPIidVKGYGTVFPVAAVASFLSLVGALF 421
GPH_sucrose TIGR01301
GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in ...
 25-163 7.11e-17

GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in plants, from the Glycoside-Pentoside-Hexuronide (GPH)/cation symporter family. These proteins are predicted to have 12 transmembrane domains. Members may export sucrose (e.g. SUT1, SUT4) from green parts to the phloem for long-distance transport or import sucrose (e.g SUT2) to sucrose sinks such as the tap root of the carrot.


Pssm-ID: 273545 [Multi-domain]  Cd Length: 477  Bit Score: 84.08  E-value: 7.11e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259   25 WSLQK----------GLPEQYYSLTWFLSPILGLIFTPLIGSASDRCTLSWGRRRPFILALCVGVLFGVALFLNGSAIGL 94
Cdd:TIGR01301  20 WALQLslltpyvqelGIPHAWASIIWLCGPLSGLLVQPLVGYLSDRCTSRFGRRRPFIAAGAALVAFAVILIGFAADIGH 99

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 122937259   95 ALGDVPNR--QPIGIVLTVLGVVVLDFSADATEGPIRAYLLDVVDSEEQDM--ALNIHAFSAGLGGAIGYVLG 163
Cdd:TIGR01301 100 LFGDNLDKktKPRAIIVFVVGFWILDVANNMLQGPCRAFLADLTGGDARRTriANAYFSFFMAIGNVLGYAAG 172
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
30-214 1.08e-10

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 64.54  E-value: 1.08e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259  30 GLPEQYYSLTWFLSPILGLIFTPLIGSASDRCTLSWGRRRPFILALcvGVLFGVALFLNGSAIGLAlgdvpnrQPIGIVL 109
Cdd:COG2211   42 GLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGRRRPWILIG--AIPLALSFVLLFTAPDLS-------PTGKLIY 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259 110 TVLGVVVLDFSADATEGPIRAYLLDVVDSEEQDMALN-IHAFSAGLGGAIGYVLGGLdwTQTFLGSWFRTQNQVLFFFAA 188
Cdd:COG2211  113 ALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSsWRFAFAGLGGLLASVLPPP--LVAAFGGDAALGYRLTALIFA 190

                        170       180
                 ....*....|....*....|....*.
gi 122937259 189 IIFTVSVALHLFSIDEEQYSPQQERS 214
Cdd:COG2211  191 VLGLLAFLLTFFGTKERPVPEEEKVS 216
MFS_1 pfam07690
Major Facilitator Superfamily;
15-220 5.26e-07

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 52.42  E-value: 5.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259   15 TLVSPLRSNQWSLQKGLPEQYYSLTWFLSPILGLIFTPLIGSASDRctlsWGRRRPFILALCVGVLFGVALFLNGSAIGL 94
Cdd:pfam07690  13 SLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDR----FGRRRVLLIGLLLFALGLLLLLFASSLWLL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259   95 ALGdvpnRQPIGIvltvlgvvvldFSAdATEGPIRAYLLDVVDSEEQDMALNIHAFSAGLGGAIGYVLGGldwtqtFLGS 174
Cdd:pfam07690  89 LVL----RVLQGL-----------GAG-ALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGG------LLAS 146

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 122937259  175 WFRTqnQVLFFFAAIIFTVSVALHLFSIDEEQYSPQQERSAEEPGA 220
Cdd:pfam07690 147 LFGW--RAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSL 190
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
448-675 9.70e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 48.74  E-value: 9.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259 448 LSMLKMPRELMRLCLCHLLTWFSVIAEAVFYTDFMGQVIfegdpkapSNSTAWQAynagvkmgcWGLVIYAATGAICSAL 527
Cdd:COG2211  221 LKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVL--------GLSAALVG---------LLLALYFLAALLGAPL 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259 528 LQKYLDNYdlSVRVIYVLGTLGFSVGTAVMAMFP--NVYVAMVTISTMGIVSMSISYCPYALLGqyhDIKQYIHHSPGns 605
Cdd:COG2211  284 WPRLAKRF--GKKKAFIIGLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLA---DVVDYDEWKTG-- 356

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259 606 KRGFGIDCAILSCQVYISQILVASALGGVVDAVG----------TVRVIPMVASVGSFLGFLTATFLVIYPNVSEEAKEE 675
Cdd:COG2211  357 RRREGLYFGIFTFAIKLGQALAGALAGLLLALFGyvagaaqspsALTGIRLLFFLLPAVLLLLAALLLLFYPLTRERHAE 436
GPH_sucrose TIGR01301
GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in ...
 448-668 6.22e-04

GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in plants, from the Glycoside-Pentoside-Hexuronide (GPH)/cation symporter family. These proteins are predicted to have 12 transmembrane domains. Members may export sucrose (e.g. SUT1, SUT4) from green parts to the phloem for long-distance transport or import sucrose (e.g SUT2) to sucrose sinks such as the tap root of the carrot.


Pssm-ID: 273545 [Multi-domain]  Cd Length: 477  Bit Score: 43.25  E-value: 6.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259  448 LSMLKMPRELMRLCLChlLTWFSVIAEAVFYTDFMGQVIFEGDPKAPsnstawQAYNAGVKMGCWGLVIYAATGAICSAL 527
Cdd:TIGR01301 253 FKYLPRPVWILLLVTC--LNWIAWFPFILFDTDWMGREVYGGSVNQG------AKYDDGVRAGAFGLMLNSVVLGITSIG 324

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259  528 LQKYLDNYDLSVR---VIYVLGTLGFSVGTAVMAMFPN-----------------VYVAMVTISTMGIvSMSISYC-PYA 586
Cdd:TIGR01301 325 MEKLCRGWGAGKRlwgIVNIILAICLAATVLVTYVAKNsryydgdgeslppptgiKASALIVFAILGI-PLAITYSiPFA 403

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259  587 LLGQYHDikqyihhspgNSKRGFGIDCAILSCQVYISQILVaSALGGVVDAVGTVRVIP--MVASVGSFLGFLTATFLVI 664
Cdd:TIGR01301 404 LASIRSS----------NLGAGQGLSMGVLNLAIVIPQIIV-SLGSGPWDQLFGGGNLPafVVGAVAAFVSGLLALILLP 472


                  ....
gi 122937259  665 YPNV 668
Cdd:TIGR01301 473 RPRV 476
 
Name Accession Description Interval E-value
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 15-219 1.63e-64

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 221.73  E-value: 1.63e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259  15 TLVSPLrsnqwsLQK-GLPEQYYSLTWFLSPILGLIFTPLIGSASDRCTLSWGRRRPFILALCVGVLFGVALFLNGSAIG 93
Cdd:cd17313   20 SYVPPI------LQTlGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCNSRIGRRRPFILVGAPLAALGLILIPNAADIG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259  94 LALGDvpNRQPIGIVLTVLGVVVLDFSADATEGPIRAYLLDVVDSEEQDMALNIHAFSAGLGGAIGYVLGGLDWTQTFLG 173
Cdd:cd17313   94 LALGD--GPRTWALVLFVLGIVLLDFAMNVCQGPVRALLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGAILWDHNWFG 171

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 122937259 174 SWFRTQNQVLFFFAAIIFTVSVALHLFSIDEEQYSPQQERSAEEPG 219
Cdd:cd17313  172 FALGGNLKVPFYIGAIILLVCVLVTLFFVKEPPLSPEAGEHSENPS 217
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 446-658 3.60e-54

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 193.23  E-value: 3.60e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259 446 LWLSMLKMPRELMRLCLCHLLTWFSVIAEAVFYTDFMGQVIFEGdpkapsNSTAWQAYNAGVKMGCWGLVIYAATGAICS 525
Cdd:cd17313  225 LLKLLKIMPRSLLRLLLVIFFWWIAFFPFELFFTDYMGEEVYHG------TSAASSHYGAGVRMGAWGLLIFSLAFLIFS 298

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259 526 ALLQKYLDNYdlSVRVIYVLGTLGFSVGTAVMAMFPNVYVAMVTISTMGIVSMSISYCPYALLGQYHDikqyihhspgNS 605
Cdd:cd17313  299 LPIGKLGKKI--GRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININPYPLVSDYHS----------ES 366

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 122937259 606 KRGFGIDCAILSCQVYISQILVASALGGV--VDAVGTVRVIPMVASVGSFLGFLT 658
Cdd:cd17313  367 GRGQGTDTGLLNLAISLAQILVSLLAGPIidVKGYGTVFPVAAVASFLSLVGALF 421
GPH_sucrose TIGR01301
GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in ...
 25-163 7.11e-17

GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in plants, from the Glycoside-Pentoside-Hexuronide (GPH)/cation symporter family. These proteins are predicted to have 12 transmembrane domains. Members may export sucrose (e.g. SUT1, SUT4) from green parts to the phloem for long-distance transport or import sucrose (e.g SUT2) to sucrose sinks such as the tap root of the carrot.


Pssm-ID: 273545 [Multi-domain]  Cd Length: 477  Bit Score: 84.08  E-value: 7.11e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259   25 WSLQK----------GLPEQYYSLTWFLSPILGLIFTPLIGSASDRCTLSWGRRRPFILALCVGVLFGVALFLNGSAIGL 94
Cdd:TIGR01301  20 WALQLslltpyvqelGIPHAWASIIWLCGPLSGLLVQPLVGYLSDRCTSRFGRRRPFIAAGAALVAFAVILIGFAADIGH 99

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 122937259   95 ALGDVPNR--QPIGIVLTVLGVVVLDFSADATEGPIRAYLLDVVDSEEQDM--ALNIHAFSAGLGGAIGYVLG 163
Cdd:TIGR01301 100 LFGDNLDKktKPRAIIVFVVGFWILDVANNMLQGPCRAFLADLTGGDARRTriANAYFSFFMAIGNVLGYAAG 172
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
30-214 1.08e-10

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 64.54  E-value: 1.08e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259  30 GLPEQYYSLTWFLSPILGLIFTPLIGSASDRCTLSWGRRRPFILALcvGVLFGVALFLNGSAIGLAlgdvpnrQPIGIVL 109
Cdd:COG2211   42 GLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGRRRPWILIG--AIPLALSFVLLFTAPDLS-------PTGKLIY 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259 110 TVLGVVVLDFSADATEGPIRAYLLDVVDSEEQDMALN-IHAFSAGLGGAIGYVLGGLdwTQTFLGSWFRTQNQVLFFFAA 188
Cdd:COG2211  113 ALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSsWRFAFAGLGGLLASVLPPP--LVAAFGGDAALGYRLTALIFA 190

                        170       180
                 ....*....|....*....|....*.
gi 122937259 189 IIFTVSVALHLFSIDEEQYSPQQERS 214
Cdd:COG2211  191 VLGLLAFLLTFFGTKERPVPEEEKVS 216
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 24-219 1.11e-10

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 64.37  E-value: 1.11e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259  24 QWSLQKGLPEQYYSLTWFLSPILGLIFTPLIGSASDRctlsWGRRRPFILALCVGVLFGVALFLNGSAIGLALGDVpnrq 103
Cdd:cd06174   21 ALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADR----FGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRF---- 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259 104 pigivltvlgvvVLDFSADATEGPIRAYLLDVVDSEEQDMALNIHAFSAGLGGAIGYVLGGldwtqtFLGSWFRTQNQVL 183
Cdd:cd06174   93 ------------LLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGG------ILASSLGFGWRAV 154

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 122937259 184 FFFAAIIFTVSVALHLFSIDEEQYSPQQERSAEEPG 219
Cdd:cd06174  155 FLIAAALALLAAILLLLVVPDPPESARAKNEEASSK 190
MFS_1 pfam07690
Major Facilitator Superfamily;
15-220 5.26e-07

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 52.42  E-value: 5.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259   15 TLVSPLRSNQWSLQKGLPEQYYSLTWFLSPILGLIFTPLIGSASDRctlsWGRRRPFILALCVGVLFGVALFLNGSAIGL 94
Cdd:pfam07690  13 SLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDR----FGRRRVLLIGLLLFALGLLLLLFASSLWLL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259   95 ALGdvpnRQPIGIvltvlgvvvldFSAdATEGPIRAYLLDVVDSEEQDMALNIHAFSAGLGGAIGYVLGGldwtqtFLGS 174
Cdd:pfam07690  89 LVL----RVLQGL-----------GAG-ALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGG------LLAS 146

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 122937259  175 WFRTqnQVLFFFAAIIFTVSVALHLFSIDEEQYSPQQERSAEEPGA 220
Cdd:pfam07690 147 LFGW--RAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSL 190
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
30-221 1.95e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 50.74  E-value: 1.95e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259  30 GLPEQYYSLTWFLSPILGLIFTPLIGSASDRctlsWGRRRPFILALCVGVLFGVALFLNGSAIGLALGdvpnRQPIGIvl 109
Cdd:COG2814   41 GASPAQAGLVVTAYLLGAALGAPLAGRLADR----FGRRRVLLLGLLLFALGSLLCALAPSLWLLLAA----RFLQGL-- 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259 110 tvlgvvvldfsADATEGPI-RAYLLDVVDSEEQDMALNIHAFSAGLGGAIGYVLGGLdWTQTFlgSWfrtqnQVLFFFAA 188
Cdd:COG2814  111 -----------GAGALFPAaLALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGL-LADLF--GW-----RWVFLVNA 171

                        170       180       190
                 ....*....|....*....|....*....|...
gi 122937259 189 IIFTVSVALHLFSIDEEQYSPQQERSAEEPGAL 221
Cdd:COG2814  172 VLALLALLLLLRLLPESRPAARARLRGSLRELL 204
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 30-197 3.09e-06

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 50.27  E-value: 3.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259  30 GLPEQYYSLTWFLSPILGLIFTPLIGSASDRctlsWGRRRPFILALCVGVLFGVALFLNGSAIGLALGdvpnrqpigivl 109
Cdd:cd17325  231 GLSPAQIGLLFGAQGLASALSQPPAGKLSDR----IGRKPLILIGLLLSAVALLLLPLATSFWLLLLL------------ 294

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259 110 tvlgVVVLDFSADATEGPIRAYLLDVVDSEEQDMALNIHAFSAGLGGAIGYVLGGLdWTQTFLGSWfrtqnqvLFFFAAI 189
Cdd:cd17325  295 ----LALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGF-LYDAFGFAT-------PFLAAAA 362


                 ....*...
gi 122937259 190 IFTVSVAL 197
Cdd:cd17325  363 LLLLAAVL 370
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 41-221 5.29e-06

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 49.53  E-value: 5.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259  41 FLSPILGLIFTPLIGSASDRctlsWGRRrPFILALCVGVLFGVALF-----LNGSAIGLALgdvpnrqpIGivltvlgvv 115
Cdd:cd17329   42 ALSAVAGIVASLIGGRLADR----FGRK-PVMLAGLLLRALGFALLgfahsPWLFAIALVL--------TG--------- 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259 116 vldFSADATEGPIRAYLLDVVDSEEQDMALNIHAFSAGLGGAIGYVLGGLdwtqtFLGSWFRTqnqvLFFFAAIIFTVSV 195
Cdd:cd17329  100 ---FGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGL-----LLLYSFRL----LFLAAAVLFLLAA 167

                        170       180
                 ....*....|....*....|....*.
gi 122937259 196 ALHLFSIDEEQYSPQQERSAEEPGAL 221
Cdd:cd17329  168 LVLLFLLPETRPKRRAAEKTEILRGY 193
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
448-675 9.70e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 48.74  E-value: 9.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259 448 LSMLKMPRELMRLCLCHLLTWFSVIAEAVFYTDFMGQVIfegdpkapSNSTAWQAynagvkmgcWGLVIYAATGAICSAL 527
Cdd:COG2211  221 LKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVL--------GLSAALVG---------LLLALYFLAALLGAPL 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259 528 LQKYLDNYdlSVRVIYVLGTLGFSVGTAVMAMFP--NVYVAMVTISTMGIVSMSISYCPYALLGqyhDIKQYIHHSPGns 605
Cdd:COG2211  284 WPRLAKRF--GKKKAFIIGLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLA---DVVDYDEWKTG-- 356

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259 606 KRGFGIDCAILSCQVYISQILVASALGGVVDAVG----------TVRVIPMVASVGSFLGFLTATFLVIYPNVSEEAKEE 675
Cdd:COG2211  357 RRREGLYFGIFTFAIKLGQALAGALAGLLLALFGyvagaaqspsALTGIRLLFFLLPAVLLLLAALLLLFYPLTRERHAE 436
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 44-200 3.15e-05

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 46.80  E-value: 3.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259  44 PILGLIFTPLIGSASDRctlsWGRRRPFILALCVGVLFGVALFLNGSAIGLALGdvpnRQPIGIVLtvlgvvvldfsadA 123
Cdd:cd17330   44 SLGQFLASPLWGRLSDR----YGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLA----RFLDGLTG-------------G 102

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 122937259 124 TEGPIRAYLLDVVDSEEQDMALNIHAFSAGLGGAIGYVLGGldwtqtFLGSWFrtQNQVLFFFAAIIFTVSVALHLF 200
Cdd:cd17330  103 NVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGG------FLSTPY--GYALPFLVAAALALLNLVLVLF 171
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 47-205 7.30e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 46.03  E-value: 7.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259  47 GLIFTPLIGSASDRctlsWGRRRPFILALCVGVLFGVALFLNGSAIGLALGdvpnRQPIGIvltvlgvvvldfsADATEG 126
Cdd:cd17325   44 QLLFSPPAGRLSDR----FGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLA----RFLQGL-------------ASAAVW 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259 127 PIR-AYLLDVVDSEEQDMALNIHAFSAGLGGAIGYVLGGldwtqtFLGSWFRTqnQVLFFFAAIIFTVSVALHLFSIDEE 205
Cdd:cd17325  103 PAAmALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGG------LLADALGY--RAPFLVCAALALLALVLALLLLPEP 174
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 40-88 2.94e-04

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 44.13  E-value: 2.94e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 122937259  40 WFLSPILGLIFTPLIGSASDRCTLSWGRRRPFIL--ALCVGVLFgVALFLN 88
Cdd:cd17332   41 FLVARIIDAINDPLMGYLIDRTRSRWGRFRPWLLwgAIPLALLF-VLLFTT 90
GPH_sucrose TIGR01301
GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in ...
 448-668 6.22e-04

GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in plants, from the Glycoside-Pentoside-Hexuronide (GPH)/cation symporter family. These proteins are predicted to have 12 transmembrane domains. Members may export sucrose (e.g. SUT1, SUT4) from green parts to the phloem for long-distance transport or import sucrose (e.g SUT2) to sucrose sinks such as the tap root of the carrot.


Pssm-ID: 273545 [Multi-domain]  Cd Length: 477  Bit Score: 43.25  E-value: 6.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259  448 LSMLKMPRELMRLCLChlLTWFSVIAEAVFYTDFMGQVIFEGDPKAPsnstawQAYNAGVKMGCWGLVIYAATGAICSAL 527
Cdd:TIGR01301 253 FKYLPRPVWILLLVTC--LNWIAWFPFILFDTDWMGREVYGGSVNQG------AKYDDGVRAGAFGLMLNSVVLGITSIG 324

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259  528 LQKYLDNYDLSVR---VIYVLGTLGFSVGTAVMAMFPN-----------------VYVAMVTISTMGIvSMSISYC-PYA 586
Cdd:TIGR01301 325 MEKLCRGWGAGKRlwgIVNIILAICLAATVLVTYVAKNsryydgdgeslppptgiKASALIVFAILGI-PLAITYSiPFA 403

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259  587 LLGQYHDikqyihhspgNSKRGFGIDCAILSCQVYISQILVaSALGGVVDAVGTVRVIP--MVASVGSFLGFLTATFLVI 664
Cdd:TIGR01301 404 LASIRSS----------NLGAGQGLSMGVLNLAIVIPQIIV-SLGSGPWDQLFGGGNLPafVVGAVAAFVSGLLALILLP 472


                  ....
gi 122937259  665 YPNV 668
Cdd:TIGR01301 473 RPRV 476
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
 32-165 8.96e-04

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 42.45  E-value: 8.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259  32 PEQYYSLTWFLSPILGLIFTPLIGSASDRCtlswGRRRPFILALC-VGVLFGVALFLNG------SAIGLALGDVpnrqp 104
Cdd:COG2270   50 ATALWGYALAIAGLLVALLAPVLGAIADRS----GRKKPFLAFFTlLGVLATAALFFVApgglwlGLLLFVLANI----- 120

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 122937259 105 igivltvlgvvvldfSADATEGPIRAYLLDVVDSEEQDMAlnihafsAGLGGAIGYVLGGL 165
Cdd:COG2270  121 ---------------GFEGSLVFYNAFLPDIATPEEIGRV-------SGLGWALGYLGGVL 159
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 460-685 1.11e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 42.03  E-value: 1.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259 460 LCLCHLLTWFSVIAEAVFYTDFMGQVIFegdpkapsnSTAWQAYNAGVKMGcwglvIYAATGAICSALLQKYldnydlSV 539
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGL---------SASQLGLLFALFSL-----GYALLQPLAGLLADRF------GR 60

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259 540 RVIYVLGTLGFSVGTAVMAMFPNVYVAMVTISTMGIVSMSISYCPYALLGQYHDIKQyihhspgnskrgFGIDCAILSCQ 619
Cdd:cd06174   61 RPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERE------------RGRALGLLQAF 128

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 122937259 620 VYISQILVASALGGVVDAVG-TVRVIPMVASVGSFLGFLTATFLVIYPNVSEEAKEEQKGLSSPLAG 685
Cdd:cd06174  129 GSVGGILGPLLGGILASSLGfGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKL 195
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 37-197 1.34e-03

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 41.79  E-value: 1.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259  37 SLTWFLspILGLIFTPLIGSASDRctlsWGRRRPFILALcvgVLFGVALFLNGSA-------IGLALgdvpnrQPIGIVL 109
Cdd:cd17504   36 VLTAYL--LVGAVSTPILGRLGDL----YGRKKVLLIVL---AIYTAGSLLAAFApnlpvliAGRAL------QGIGGAV 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259 110 TvlgvvvldfsadategPIrAYLL--DVVDSEEQDMALNIHAFSAGLGGAIGYVLGGldWTQTFLGsWfrtqnQVLFFFA 187
Cdd:cd17504  101 F----------------PL-AFALvrEEFPPERVPVAQGILSATFGIGAGIGLPLGG--WIVQHLG-W-----RWIFWTA 155

                        170
                 ....*....|
gi 122937259 188 AIIFTVSVAL 197
Cdd:cd17504  156 APVAVLLAAL 165
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
 30-88 1.48e-03

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 41.91  E-value: 1.48e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 122937259   30 GLPEQYYSLTWFLSPILGLIFTPLIGSASDRCTLSWGRRRPFILALCVGVLFGVALFLN 88
Cdd:pfam13347  29 GLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTRTRWGRRRPWLLLSAIILAVSFILLFT 87
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 45-197 2.97e-03

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 40.67  E-value: 2.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259  45 ILGLIFTPLIGSASDRctlsWGRRrpFILALCVgVLFGVALFLNGSAIGLALGdVPNRQPIGIVLTvlgvvvldfsadaT 124
Cdd:cd17390   42 ALQLFSSPLVGSWSDV----VGRR--PVLLICL-LLTALGYVLLGFSTSLALL-FLSRIPLGIFKH-------------T 100

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 122937259 125 EGPIRAYLLDVVDSEEQDMAL-NIHAFSaGLGGAIGYVLGGldwtqtFLGSWFRTQnQVLFFFAAIIFTVSVAL 197
Cdd:cd17390  101 QSLCKAYLSDLVSEQERSRVLgRFNAAS-SLGFILGPVVGG------HLAETDGGF-YYVALLCSAIFILNAGL 166
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 49-200 3.39e-03

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 40.18  E-value: 3.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259  49 IFTPLIGSASDRctlsWGRRRPFILALcvgVLFGVALFLNG---SAIGLALGdvpnR--QPIGIvltvlgvvvldfsadA 123
Cdd:COG0477   64 IGLLLFGRLGDR----YGRKRVLLIGL---LLFGLASLLCGlapSPELLIAA----RalQGIGA---------------G 117

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 122937259 124 TEGPI-RAYLLDVVDSEEQDMALNIHAFSAGLGGAIGYVLGGLDWTqtfLGSWfrtqnQVLFFFAAIIFTVSVALHLF 200
Cdd:COG0477  118 GLMPGaLALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVA---ALGW-----RWIFLINAPLGLLALVLRLR 187
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 28-199 4.18e-03

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 40.22  E-value: 4.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259  28 QKGLPEQYYSLTWFLSPILGLIFTPLIGSASDRctlsWGRRRPFILALCVGVLFGVALFLNGSAIGLALGDVPnrqpIGI 107
Cdd:cd17370  228 ELGLSAALIPLLYALFNLVYALAAYPAGRLSDR----IGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFIL----WGL 299

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259 108 VLTvlgvvvldfsadATEGPIRAYLLDVVDSEEQDMALNIHAFSAGLGGAIGYVLGGLDWTQTFLgswfrtqnQVLFFFA 187
Cdd:cd17370  300 YMG------------AQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISP--------SAAFLFS 359

                        170
                 ....*....|..
gi 122937259 188 AIIFTVSVALHL 199
Cdd:cd17370  360 AVLALIALLLLL 371
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
30-158 5.24e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 39.96  E-value: 5.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259  30 GLPEQYYSLTWFLSPILGLIFTPLIGSASDRctlsWGRRRPFILALCVGVLFGVALFLNGSAIGLALGdvpnrqpigivl 109
Cdd:COG2814  239 GLSASAAGLLLALFGLGGVLGALLAGRLADR----FGRRRLLLIGLLLLALGLLLLALAGSLWLLLLA------------ 302

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 122937259 110 tvlgVVVLDFSADATEGPIRAYLLDVVDSEEQDMALNIHAFSAGLGGAI 158
Cdd:COG2814  303 ----LFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 28-87 6.06e-03

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 39.82  E-value: 6.06e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937259  28 QKGLPEQYYSLTWFLSPILGLIFTPLIGSASDRctlsWGRRRPFILALCVGVLFGVALFL 87
Cdd:cd17369  258 TLGVDRSTVLLAVLIASVVAAITIPLFGWLSDR----VGRRPVYLAGALLAALFAFPFFW 313
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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