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Conserved domains on  [gi|122937261|ref|NP_001073902|]
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coiled-coil domain-containing protein 85A isoform 2 [Homo sapiens]

Protein Classification

coiled-coil domain-containing protein 85( domain architecture ID 10562961)

coiled-coil domain-containing protein 85 (CCDC85) such as Homo sapiens CCDC85C which may, through interactions with proteins of the beta-catenin family, play a role in cell-cell adhesion and epithelium development

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CCDC85 pfam10226
CCDC85 family; This entry includes human CCDC85A/B/C and C. elegans Picc-1 protein. Picc-1 ...
34-224 2.42e-92

CCDC85 family; This entry includes human CCDC85A/B/C and C. elegans Picc-1 protein. Picc-1 serves as a linker protein which helps to recruit the Rho GTPase-activating protein, pac-1, to adherens junctions. Human CCDC85B suppresses the beta-catenin activity in a p53-dependent manner.


:

Pssm-ID: 463009 [Multi-domain]  Cd Length: 192  Bit Score: 280.90  E-value: 2.42e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937261   34 EDLSKVSDEELLQWSKEELIRSLRRAEAEKVSAMLDHSNLIREVNRRLQLHLGEIRGLKDINQKLQEDNQELRDLCCFLD 113
Cdd:pfam10226   2 EDLSKLTDEELLRWSKEELVRRLRRAEAEKMSLLVEHGRLMREVNRRLQQHLLEIRGLKDVNQKLQEDNQELRDLCCFLD 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937261  114 DDRQKGKRVSREWQRLGRYTAGVMHKEVALYLQKLKDLEVKQEEVVKENMELKELCVLLDEEKGAgcAGSRCSIDSQASL 193
Cdd:pfam10226  82 DDRQKGKKVAREWQRFGRYAAGVMRKEVAGYLQKLKELEARQEELVRENLELKELCLMLDEERAG--AGCRSSIDSQSSL 159
                         170       180       190
                  ....*....|....*....|....*....|...
gi 122937261  194 CQL--TASTAPYVRDVGDGSSTSSTGSTDSPDH 224
Cdd:pfam10226 160 SQLngGLPLPGLARDVGDGSSTSSTGSVGSPDH 192
PTZ00449 super family cl33186
104 kDa microneme/rhoptry antigen; Provisional
224-327 4.04e-03

104 kDa microneme/rhoptry antigen; Provisional


The actual alignment was detected with superfamily member PTZ00449:

Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 40.06  E-value: 4.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937261 224 HHKHHASSGSPEHLQKPRSEGSPEHSK-------HR-------SASPEHPQKPRACGTPDRPKALKGP--------SPEH 281
Cdd:PTZ00449 533 EHEDSKESDEPKEGGKPGETKEGEVGKkpgpakeHKpskiptlSKKPEFPKDPKHPKDPEEPKKPKRPrsaqrptrPKSP 612
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 122937261 282 HKPLCKGSPEQQRHPHPGSSPETLPKHVLSGSPEHFQKHRSGSSPE 327
Cdd:PTZ00449 613 KLPELLDIPKSPKRPESPKSPKRPPPPQRPSSPERPEGPKIIKSPK 658
 
Name Accession Description Interval E-value
CCDC85 pfam10226
CCDC85 family; This entry includes human CCDC85A/B/C and C. elegans Picc-1 protein. Picc-1 ...
34-224 2.42e-92

CCDC85 family; This entry includes human CCDC85A/B/C and C. elegans Picc-1 protein. Picc-1 serves as a linker protein which helps to recruit the Rho GTPase-activating protein, pac-1, to adherens junctions. Human CCDC85B suppresses the beta-catenin activity in a p53-dependent manner.


Pssm-ID: 463009 [Multi-domain]  Cd Length: 192  Bit Score: 280.90  E-value: 2.42e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937261   34 EDLSKVSDEELLQWSKEELIRSLRRAEAEKVSAMLDHSNLIREVNRRLQLHLGEIRGLKDINQKLQEDNQELRDLCCFLD 113
Cdd:pfam10226   2 EDLSKLTDEELLRWSKEELVRRLRRAEAEKMSLLVEHGRLMREVNRRLQQHLLEIRGLKDVNQKLQEDNQELRDLCCFLD 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937261  114 DDRQKGKRVSREWQRLGRYTAGVMHKEVALYLQKLKDLEVKQEEVVKENMELKELCVLLDEEKGAgcAGSRCSIDSQASL 193
Cdd:pfam10226  82 DDRQKGKKVAREWQRFGRYAAGVMRKEVAGYLQKLKELEARQEELVRENLELKELCLMLDEERAG--AGCRSSIDSQSSL 159
                         170       180       190
                  ....*....|....*....|....*....|...
gi 122937261  194 CQL--TASTAPYVRDVGDGSSTSSTGSTDSPDH 224
Cdd:pfam10226 160 SQLngGLPLPGLARDVGDGSSTSSTGSVGSPDH 192
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
224-327 4.04e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 40.06  E-value: 4.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937261 224 HHKHHASSGSPEHLQKPRSEGSPEHSK-------HR-------SASPEHPQKPRACGTPDRPKALKGP--------SPEH 281
Cdd:PTZ00449 533 EHEDSKESDEPKEGGKPGETKEGEVGKkpgpakeHKpskiptlSKKPEFPKDPKHPKDPEEPKKPKRPrsaqrptrPKSP 612
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 122937261 282 HKPLCKGSPEQQRHPHPGSSPETLPKHVLSGSPEHFQKHRSGSSPE 327
Cdd:PTZ00449 613 KLPELLDIPKSPKRPESPKSPKRPPPPQRPSSPERPEGPKIIKSPK 658
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
33-176 7.45e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 39.28  E-value: 7.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937261  33 VEDLSKVSDEELLQWSKE-----ELIRSLRRaEAEKVSAML----DHSNLIREVNRRLQLHLGEIRGLKD--------IN 95
Cdd:PRK03918 191 IEELIKEKEKELEEVLREineisSELPELRE-ELEKLEKEVkeleELKEEIEELEKELESLEGSKRKLEEkireleerIE 269
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937261  96 QK----------------LQEDNQELRDLCCFLDDDRQKGKRVSREWQRLGRYTAGVMH--KEVALYLQKLKDLEVKQEE 157
Cdd:PRK03918 270 ELkkeieeleekvkelkeLKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEEriKELEEKEERLEELKKKLKE 349
                        170
                 ....*....|....*....
gi 122937261 158 VVKENMELKELCVLLDEEK 176
Cdd:PRK03918 350 LEKRLEELEERHELYEEAK 368
 
Name Accession Description Interval E-value
CCDC85 pfam10226
CCDC85 family; This entry includes human CCDC85A/B/C and C. elegans Picc-1 protein. Picc-1 ...
34-224 2.42e-92

CCDC85 family; This entry includes human CCDC85A/B/C and C. elegans Picc-1 protein. Picc-1 serves as a linker protein which helps to recruit the Rho GTPase-activating protein, pac-1, to adherens junctions. Human CCDC85B suppresses the beta-catenin activity in a p53-dependent manner.


Pssm-ID: 463009 [Multi-domain]  Cd Length: 192  Bit Score: 280.90  E-value: 2.42e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937261   34 EDLSKVSDEELLQWSKEELIRSLRRAEAEKVSAMLDHSNLIREVNRRLQLHLGEIRGLKDINQKLQEDNQELRDLCCFLD 113
Cdd:pfam10226   2 EDLSKLTDEELLRWSKEELVRRLRRAEAEKMSLLVEHGRLMREVNRRLQQHLLEIRGLKDVNQKLQEDNQELRDLCCFLD 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937261  114 DDRQKGKRVSREWQRLGRYTAGVMHKEVALYLQKLKDLEVKQEEVVKENMELKELCVLLDEEKGAgcAGSRCSIDSQASL 193
Cdd:pfam10226  82 DDRQKGKKVAREWQRFGRYAAGVMRKEVAGYLQKLKELEARQEELVRENLELKELCLMLDEERAG--AGCRSSIDSQSSL 159
                         170       180       190
                  ....*....|....*....|....*....|...
gi 122937261  194 CQL--TASTAPYVRDVGDGSSTSSTGSTDSPDH 224
Cdd:pfam10226 160 SQLngGLPLPGLARDVGDGSSTSSTGSVGSPDH 192
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
224-327 4.04e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 40.06  E-value: 4.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937261 224 HHKHHASSGSPEHLQKPRSEGSPEHSK-------HR-------SASPEHPQKPRACGTPDRPKALKGP--------SPEH 281
Cdd:PTZ00449 533 EHEDSKESDEPKEGGKPGETKEGEVGKkpgpakeHKpskiptlSKKPEFPKDPKHPKDPEEPKKPKRPrsaqrptrPKSP 612
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 122937261 282 HKPLCKGSPEQQRHPHPGSSPETLPKHVLSGSPEHFQKHRSGSSPE 327
Cdd:PTZ00449 613 KLPELLDIPKSPKRPESPKSPKRPPPPQRPSSPERPEGPKIIKSPK 658
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
33-176 7.45e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 39.28  E-value: 7.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937261  33 VEDLSKVSDEELLQWSKE-----ELIRSLRRaEAEKVSAML----DHSNLIREVNRRLQLHLGEIRGLKD--------IN 95
Cdd:PRK03918 191 IEELIKEKEKELEEVLREineisSELPELRE-ELEKLEKEVkeleELKEEIEELEKELESLEGSKRKLEEkireleerIE 269
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937261  96 QK----------------LQEDNQELRDLCCFLDDDRQKGKRVSREWQRLGRYTAGVMH--KEVALYLQKLKDLEVKQEE 157
Cdd:PRK03918 270 ELkkeieeleekvkelkeLKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEEriKELEEKEERLEELKKKLKE 349
                        170
                 ....*....|....*....
gi 122937261 158 VVKENMELKELCVLLDEEK 176
Cdd:PRK03918 350 LEKRLEELEERHELYEEAK 368
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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