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Conserved domains on  [gi|124248497|ref|NP_001074271|]
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sodium channel subunit beta-3 precursor [Danio rerio]

Protein Classification

immunoglobulin domain-containing protein( domain architecture ID 10542315)

immunoglobulin (Ig) domain-containing protein adopts a fold comprised of a sandwich of two beta sheets, similar to Homo sapiens T-cell antigen CD7 and voltage-gated sodium channel beta3 subunit Ig Domain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 29-137 1.89e-15

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


:

Pssm-ID: 462230  Cd Length: 109  Bit Score: 69.41  E-value: 1.89e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124248497   29 VPSDGEAIVGKVKKLTCIYcmKREEILATTKVEWfYKGQDKNKTRTLIYLYDGEPQEPKDvdeqwKGRVTWTGSKDMQDV 108
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTY--SSSMSEASTSVYW-YRQPPGKGPTFLIAYYSNGSEEGVK-----KGRFSGRGDPSNGDG 73

                          90       100
                  ....*....|....*....|....*....
gi 124248497  109 SISILNVTLNDTGTYECEVTRFFEFDSFK 137
Cdd:pfam07686  74 SLTIQNLTLSDSGTYTCAVIPSGEGVFGK 102
 
Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 29-137 1.89e-15

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 69.41  E-value: 1.89e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124248497   29 VPSDGEAIVGKVKKLTCIYcmKREEILATTKVEWfYKGQDKNKTRTLIYLYDGEPQEPKDvdeqwKGRVTWTGSKDMQDV 108
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTY--SSSMSEASTSVYW-YRQPPGKGPTFLIAYYSNGSEEGVK-----KGRFSGRGDPSNGDG 73

                          90       100
                  ....*....|....*....|....*....
gi 124248497  109 SISILNVTLNDTGTYECEVTRFFEFDSFK 137
Cdd:pfam07686  74 SLTIQNLTLSDSGTYTCAVIPSGEGVFGK 102
IgV_P0-like cd05715
Immunoglobulin (Ig)-like domain of protein zero (P0) and similar proteins; The members here ...
 27-127 9.03e-12

Immunoglobulin (Ig)-like domain of protein zero (P0) and similar proteins; The members here are composed of the immunoglobulin (Ig) domain of protein zero (P0), a myelin membrane adhesion molecule. P0 accounts for over 50% of the total protein in peripheral nervous system (PNS) myelin. P0 is a single-pass transmembrane glycoprotein with a highly basic intracellular domain and an extracellular Ig domain. The extracellular domain of P0 (P0-ED) is similar to the Ig variable domain, carrying one acceptor sequence for N-linked glycosylation. P0 plays a role in membrane adhesion in the spiral wraps of the myelin sheath. The intracellular domain is thought to mediate membrane apposition of the cytoplasmic faces and may, through electrostatic interactions, interact directly with lipid headgroups. It is thought that homophilic interactions of the P0 extracellular domain mediate membrane juxtaposition in the extracellular space of PNS myelin. This group also contains the Ig domain of sodium channel subunit beta-2 (SCN2B), and of epithelial V-like antigen 1 (EVA). EVA, also known as myelin protein zero-like 2, is an adhesion molecule, which may play a role in structural organization of the thymus and early lymphocyte development. SCN2B subunits play a role in determining sodium channel density and function in neurons,and in control of electrical excitability in the brain.


Pssm-ID: 409380  Cd Length: 117  Bit Score: 59.75  E-value: 9.03e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124248497  27 VDVPSDGEAIVGKVKKLTCIYcMKREEILATTKVEWFYKGQDKNKTRTLIYLYDGEPQEPKDvdEQWKGRVTWTGSKDMQ 106
Cdd:cd05715    3 VYTPRELNVLNGSDVRLTCTF-TSCYTVGDAFSVTWTYQPEGGNTTESMFHYSKGKPYILKV--GRFKDRVSWAGNPSKK 79

                         90       100
                 ....*....|....*....|.
gi 124248497 107 DVSISILNVTLNDTGTYECEV 127
Cdd:cd05715   80 DASIVISNLQFSDNGTYTCDV 100
IGv smart00406
Immunoglobulin V-Type;
60-127 1.18e-06

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 45.07  E-value: 1.18e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 124248497    60 VEWFYKGQDKnKTRTLIYLYDGEPQEPkdvDEQWKGRVTWTGSKDMQDVSISILNVTLNDTGTYECEV 127
Cdd:smart00406  18 VSWVRQPPGK-GLEWLGYIGSNGSSYY---QESYKGRFTISKDTSKNDVSLTISNLRVEDTGTYYCAV 81
 
Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 29-137 1.89e-15

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 69.41  E-value: 1.89e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124248497   29 VPSDGEAIVGKVKKLTCIYcmKREEILATTKVEWfYKGQDKNKTRTLIYLYDGEPQEPKDvdeqwKGRVTWTGSKDMQDV 108
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTY--SSSMSEASTSVYW-YRQPPGKGPTFLIAYYSNGSEEGVK-----KGRFSGRGDPSNGDG 73

                          90       100
                  ....*....|....*....|....*....
gi 124248497  109 SISILNVTLNDTGTYECEVTRFFEFDSFK 137
Cdd:pfam07686  74 SLTIQNLTLSDSGTYTCAVIPSGEGVFGK 102
IgV_P0-like cd05715
Immunoglobulin (Ig)-like domain of protein zero (P0) and similar proteins; The members here ...
 27-127 9.03e-12

Immunoglobulin (Ig)-like domain of protein zero (P0) and similar proteins; The members here are composed of the immunoglobulin (Ig) domain of protein zero (P0), a myelin membrane adhesion molecule. P0 accounts for over 50% of the total protein in peripheral nervous system (PNS) myelin. P0 is a single-pass transmembrane glycoprotein with a highly basic intracellular domain and an extracellular Ig domain. The extracellular domain of P0 (P0-ED) is similar to the Ig variable domain, carrying one acceptor sequence for N-linked glycosylation. P0 plays a role in membrane adhesion in the spiral wraps of the myelin sheath. The intracellular domain is thought to mediate membrane apposition of the cytoplasmic faces and may, through electrostatic interactions, interact directly with lipid headgroups. It is thought that homophilic interactions of the P0 extracellular domain mediate membrane juxtaposition in the extracellular space of PNS myelin. This group also contains the Ig domain of sodium channel subunit beta-2 (SCN2B), and of epithelial V-like antigen 1 (EVA). EVA, also known as myelin protein zero-like 2, is an adhesion molecule, which may play a role in structural organization of the thymus and early lymphocyte development. SCN2B subunits play a role in determining sodium channel density and function in neurons,and in control of electrical excitability in the brain.


Pssm-ID: 409380  Cd Length: 117  Bit Score: 59.75  E-value: 9.03e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124248497  27 VDVPSDGEAIVGKVKKLTCIYcMKREEILATTKVEWFYKGQDKNKTRTLIYLYDGEPQEPKDvdEQWKGRVTWTGSKDMQ 106
Cdd:cd05715    3 VYTPRELNVLNGSDVRLTCTF-TSCYTVGDAFSVTWTYQPEGGNTTESMFHYSKGKPYILKV--GRFKDRVSWAGNPSKK 79

                         90       100
                 ....*....|....*....|.
gi 124248497 107 DVSISILNVTLNDTGTYECEV 127
Cdd:cd05715   80 DASIVISNLQFSDNGTYTCDV 100
IgV_EVA1 cd05880
Immunoglobulin (Ig)-like domain of epithelial V-like antigen (EVA) 1; The members here are ...
 27-127 2.42e-08

Immunoglobulin (Ig)-like domain of epithelial V-like antigen (EVA) 1; The members here are composed of the immunoglobulin (Ig) domain of epithelial V-like antigen 1 (EVA 1). EVA is also known as myelin protein zero-like 2. EVA is an adhesion molecule and may play a role in the structural organization of the thymus and early lymphocyte development.


Pssm-ID: 409464  Cd Length: 116  Bit Score: 50.60  E-value: 2.42e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124248497  27 VDVPSDGEAIVGKVKKLTCIYCmKREEILATTKVEWFYKGQDKNKTRTLIYlYDGEPQEPkdVDEQWKGRVTWTGSKDMQ 106
Cdd:cd05880    3 VYTSKEVEAVNGTDVRLKCTFS-SSAPIGDTLVITWNFRPLDGGREESVFY-YHKRPYPP--PDGRFKGRVVWDGNIMRR 78

                         90       100
                 ....*....|....*....|.
gi 124248497 107 DVSISILNVTLNDTGTYECEV 127
Cdd:cd05880   79 DASILIWQLQPTDNGTYTCQV 99
IGv smart00406
Immunoglobulin V-Type;
60-127 1.18e-06

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 45.07  E-value: 1.18e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 124248497    60 VEWFYKGQDKnKTRTLIYLYDGEPQEPkdvDEQWKGRVTWTGSKDMQDVSISILNVTLNDTGTYECEV 127
Cdd:smart00406  18 VSWVRQPPGK-GLEWLGYIGSNGSSYY---QESYKGRFTISKDTSKNDVSLTISNLRVEDTGTYYCAV 81
IgV_CAR_like cd20960
Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and ...
 34-127 2.59e-06

Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins; The members here are composed of the Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins. CAR, which is encoded by human CXADR gene, is a cell adhesion molecule of the Immunoglobulin (Ig) superfamily. The CAR acts as a type I membrane receptor for group B1-B6 coxsackie viruses and subgroup C adenoviruses. For instance, adenovirus interacts with the coxsackievirus and adenovirus receptor to enter epithelial airway cells. The CAR is also shown to be involved in physiological processes such as neuronal and heart development, epithelial tight junction integrity, and tumor suppression. The CAR is a component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. The CAR is also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. The CAR is composed of one V-set and one C2-set Ig module, a single transmembrane helix, and an intracellular domain. This group belongs to the V-set of IgSF domains, having A, B, E and D strands in one beta-sheet and A', G, F, C, C' and C" in the other


Pssm-ID: 409552  Cd Length: 114  Bit Score: 44.75  E-value: 2.59e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124248497  34 EAIVGKVKKLTCIYCMKREEIlATTKVEWFYKGQDKNKtRTLIyLYDGEpQEPKDVDEQWKGRVTWTGSKDMQDVSISIL 113
Cdd:cd20960   11 KKVAGENVTLPCHHQLGLEDQ-GTLDIEWLLLPSDKVE-KVVI-TYSGD-RVYNHYYPALKGRVAFTSNDLSGDASLNIS 86

                         90
                 ....*....|....
gi 124248497 114 NVTLNDTGTYECEV 127
Cdd:cd20960   87 NLKLSDTGTYQCKV 100
IgV_1_JAM1-like cd20946
First Ig-like domain of Junctional adhesion molecule-1 (JAM1)and similar domains; a member of ...
 27-128 7.79e-05

First Ig-like domain of Junctional adhesion molecule-1 (JAM1)and similar domains; a member of the V-set of IgSF domains; The members here are composed of the first Ig-like domain of Junctional Adhesion Molecule-1 (JAM1)and similar domains. JAM1 is an immunoglobulin superfamily (IgSF) protein with two Ig-like domains in its extracellular region; it plays a role in the formation of endothelial and epithelial tight junction and acts as a receptor for mammalian reovirus sigma-1. The IgSF is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. The two sheets are linked together by a conserved disulfide bond between B strand and F strand. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The first Ig-like domain of JAM1 is a member of the V-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C'-C" in the other.


Pssm-ID: 409538  Cd Length: 102  Bit Score: 40.60  E-value: 7.79e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124248497  27 VDVPSDGEAIvgkvkkLTCIYCMKReeilATTKVEWFYKGQDKnktrTLIYLYDGepqepkDVDEQWKGRVTwtgskdMQ 106
Cdd:cd20946    9 VTVVENQEVI------LSCKTPKKT----SSPRVEWKKLQRDV----TFVVFQNN------KIQGDYKGRAE------IL 62

                         90       100
                 ....*....|....*....|..
gi 124248497 107 DVSISILNVTLNDTGTYECEVT 128
Cdd:cd20946   63 GTNITIKNVTRSDSGKYRCEVS 84
IgV_MOG_like cd05713
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here ...
 35-136 9.28e-05

Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here are composed of the immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG). MOG, a minor component of the myelin sheath, is an important CNS-specific autoantigen, linked to the pathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). It is a transmembrane protein having an extracellular Ig domain. MOG is expressed in the CNS on the outermost lamellae of the myelin sheath, and on the surface of oligodendrocytes, and may participate in the completion, compaction, and/or maintenance of myelin. This group also includes butyrophilin (BTN). BTN is the most abundant protein in bovine milk-fat globule membrane (MFGM).


Pssm-ID: 409378  Cd Length: 114  Bit Score: 40.64  E-value: 9.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124248497  35 AIVGKVKKLTCIYCMKREeiLATTKVEWFykgqdKNKTRTLIYLY-DGEPQePKDVDEQWKGRVTWTgSKDMQD--VSIS 111
Cdd:cd05713   12 ALVGEDAELPCHLSPKMS--AEHMEVRWF-----RSQFSPVVHLYrDGQDQ-EEEQMPEYRGRTELL-KDAIAEgsVALR 82

                         90       100
                 ....*....|....*....|....*
gi 124248497 112 ILNVTLNDTGTYECevtrFFEFDSF 136
Cdd:cd05713   83 IHNVRPSDEGQYTC----FFRSGSF 103
IgV_P0 cd05879
Immunoglobulin (Ig)-like domain of protein zero (P0); The members here are composed of the ...
 27-127 1.12e-04

Immunoglobulin (Ig)-like domain of protein zero (P0); The members here are composed of the immunoglobulin (Ig) domain of protein zero (P0), a myelin membrane adhesion molecule. P0 accounts for over 50% of the total protein in peripheral nervous system (PNS) myelin. P0 is a single-pass transmembrane glycoprotein with a highly basic intracellular domain and an Ig domain. The extracellular domain of P0 (P0-ED) is similar to the Ig variable domain, carrying one acceptor sequence for N-linked glycosylation. P0 plays a role in membrane adhesion in the spiral wraps of the myelin sheath. The intracellular domain is thought to mediate membrane apposition of the cytoplasmic faces and may, through electrostatic interactions, interact directly with lipid headgroups. It is thought that homophilic interactions of the P0 extracellular domain mediate membrane juxtaposition in the extracellular space of PNS myelin.


Pssm-ID: 409463  Cd Length: 117  Bit Score: 40.24  E-value: 1.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124248497  27 VDVPSDGEAIVGKVKKLTCIYcMKREEILATTKVEWFYKGQDKNKTRTLIYLYDGEPQePKDVDeQWKGRVTWTGSKDMQ 106
Cdd:cd05879    3 VYTDREVYGTVGSDVTLSCSF-WSSEWISDDISFTWHYQPDGSRDAISIFHYGKGQPY-IDNVG-PFKERIEWVGNPSRK 79

                         90       100
                 ....*....|....*....|.
gi 124248497 107 DVSISILNVTLNDTGTYECEV 127
Cdd:cd05879   80 DGSIVIHNLDYTDNGTFTCDV 100
Ig0_BSG1 cd20940
Immunoglobulin-like Ig0 domain of basigin-1 (BSG1) and similar proteins; The members here are ...
 59-125 1.24e-04

Immunoglobulin-like Ig0 domain of basigin-1 (BSG1) and similar proteins; The members here are composed of the immunoglobulin (Ig) domain of the collagenase stimulatory factor, basigin-1 (BSG1; also known as Cluster of Differentiation 147 (CD147) and Extracellular Matrix Metalloproteinase Inducer (EMMPRIN)) and similar proteins. CD147 is a transmembrane glycoprotein that belongs to the immunoglobulin superfamily. It is expressed in nearly all cells including platelets and fibroblasts and is involved in inflammatory diseases, and cancer progression. CD147 is highly expressed in several cancers and used as a prognostic marker. The two primary isoforms of CD147 that are related to cancer progression have been identified: CD147 Ig1-Ig2 (also called Basigin-2) that is ubiquitously expressed in most tissues and CD147 Ig0-Ig1-Ig2 (also called Basigin-1) that is retinal specific and implicated in retinoblastoma. Studies showed that CD147 Ig0 domain is a potent stimulator of interleukin-6 and suggest that the CD147 Ig0 dimer is the functional unit required for activity.


Pssm-ID: 409534  Cd Length: 116  Bit Score: 40.33  E-value: 1.24e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 124248497  59 KVEWFYKGQDKNKTRTliYLYDGepqepkdvdeQWKGRVTWTGSKDMQDVS-ISILNVTLNDTGTYEC 125
Cdd:cd20940   31 EIQWWFEGQEPNEICS--QLWDG----------ARLDRVHINATYHQHATStISIDNLTEEDTGTYEC 86
IgV_1_PVR_like cd05718
First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 ...
 27-130 1.39e-04

First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 and necl-5), and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and nectin-like protein 5 (necl-5)). Poliovirus (PV) binds to its cellular receptor (PVR/CD155) to initiate infection. CD155 is a membrane-anchored, single-span glycoprotein; its extracellular region has three Ig-like domains. There are four different isotypes of CD155 (referred to as alpha, beta, gamma, and delta), that result from alternate splicing of the CD155 mRNA, and have identical extracellular domains. CD155-beta and CD155-gamma are secreted; CD155-alpha and CD155-delta are membrane-bound and function as PV receptors. The virus recognition site is contained in the amino-terminal domain, D1. Having the virus attachment site on the receptor distal from the plasma membrane may be important for successful initiation of infection of cells by the virus. CD155 binds in the poliovirus "canyon" with a footprint similar to that of the intercellular adhesion molecule-1 receptor on human rhinoviruses. This group also includes the first Ig-like domain of nectin-1 (also known as poliovirus receptor related protein(PVRL)1; CD111), nectin-3 (also known as PVRL 3), nectin-4 (also known as PVRL4; LNIR receptor)and DNAX accessory molecule 1 (DNAM-1; CD226).


Pssm-ID: 409383  Cd Length: 113  Bit Score: 40.12  E-value: 1.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124248497  27 VDVPSDGEAIVGKVKKLTCIYCMKREEILatTKVEWFYKGqdkNKTRTLIYLYdgEPQEPKDVDEQWKGRVTWTGSK-DM 105
Cdd:cd05718    3 VQVPTEVTGFLGGSVTLPCSLTSPGTTKI--TQVTWMKIG---AGSSQNVAVF--HPQYGPSVPNPYAERVEFLAARlGL 75

                         90       100
                 ....*....|....*....|....*
gi 124248497 106 QDVSISILNVTLNDTGTYECEVTRF 130
Cdd:cd05718   76 RNATLRIRNLRVEDEGNYICEFATF 100
Ig_LP_like cd05877
Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains; The ...
 94-135 2.55e-04

Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains; The members here are composed of the immunoglobulin (Ig)-like domain similar to that found in human cartilage link protein (LP; also called hyaluronan and proteoglycan link protein). In cartilage, chondroitin-keratan sulfate proteoglycan (CSPG), aggrecan, forms cartilage link protein stabilized aggregates with hyaluronan (HA). These aggregates contribute to the tissue's load bearing properties. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409461  Cd Length: 117  Bit Score: 39.23  E-value: 2.55e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 124248497  94 KGRVTWTGSKDMqDVSISILNVTLNDTGTYECEVTRFFEFDS 135
Cdd:cd05877   65 QGRVFLRRADDL-DASLVITDLRLEDYGRYRCEVIDGLEDES 105
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 30-128 8.97e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 37.10  E-value: 8.97e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124248497    30 PSDGEAIVGKVKKLTCIYcmkreEILATTKVEWFykgqdKNKTRTLIYlydgepqepkdvdeqwKGRVTWTGSKDmqDVS 109
Cdd:smart00410   1 PPSVTVKEGESVTLSCEA-----SGSPPPEVTWY-----KQGGKLLAE----------------SGRFSVSRSGS--TST 52

                           90
                   ....*....|....*....
gi 124248497   110 ISILNVTLNDTGTYECEVT 128
Cdd:smart00410  53 LTISNVTPEDSGTYTCAAT 71
IgV_TIM-3_like cd20982
Immunoglobulin Variable (IgV) domain of T cell Immunoglobulin Domain and Mucin Domain 3 (Tim-3) ...
 35-127 4.12e-03

Immunoglobulin Variable (IgV) domain of T cell Immunoglobulin Domain and Mucin Domain 3 (Tim-3), and similar domains; The members here are composed of the immunoglobulin variable (IgV) domain of T cell immunoglobulin domain and mucin domain 3 (Tim-3; also known as Hepatitis A virus cellular receptor 2 (HAVcr-2) and Cluster of Differentiation 366 (CD366)) and similar proteins. TIM-3 is a checkpoint inhibitor in immune responses to tumors, as well as involved in chronic viral infections. Thus, Tim-3 has emerged as one of most promising immune checkpoint targets for cancer immunotherapy. Tim-3 is highly expressed on Th1 lymphocytes and CD11b(+) macrophages and is upregulated on activated T and myeloid cells. TIM-3 regulates macrophage, activation and inhibits Th1 mediated immune responses to promote immunological tolerance. There are three TIM family members in humans (TIM-1, TIM-3, and TIM-4) and eight members in mice (TIM-1 to TIM-8). The IgV domain of human TIM-3 has been shown to bind ligands such as carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1), high mobility group protein B1 (HMGB1)and galectin-9 (GAL9). The binding of GAL9 to TIM-3 can negatively regulate Th1 immune response, enhance immune tolerance and inhibit anti#tumor immunity. Dysregulation of the TIM-3/GAL9 pathway is implicated in numerous chronic autoimmune diseases, such as multiple sclerosis and systemic lupus erythematosus.


Pssm-ID: 409574  Cd Length: 107  Bit Score: 35.90  E-value: 4.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124248497  35 AIVGKVKKLTCIYCMKREEILATT-----KVEWFYKgqdknkTRTLIYlydgepQEPKDVDEQWKGRVTWTGSKDMQDVS 109
Cdd:cd20982    5 AEVGHNAYLPCSYTTAAPGNLVPVcwgkgACPVSYC------GNVLLR------TDERDVTYQKSSRYQLKGDFSKGDVS 72

                         90
                 ....*....|....*...
gi 124248497 110 ISILNVTLNDTGTYECEV 127
Cdd:cd20982   73 LTIENVTLADSGIYCCRI 90
IgI_hCEACAM_2_4_6_like cd05740
Immunoglobulin (Ig)-like domain of human carcinoembryonic antigen (CEA) related cell adhesion ...
 110-151 5.77e-03

Immunoglobulin (Ig)-like domain of human carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) domains 2, 4, and 6, and similar domains; The members here are composed of the second, fourth, and sixth immunoglobulin (Ig)-like domains in human carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) protein subfamily. The CEA family is a group of anchored or secreted glycoproteins expressed by epithelial cells, leukocytes, endothelial cells, and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions; it is a cell adhesion molecule and a signaling molecule that regulates the growth of tumor cells, an angiogenic factor, and a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two [D1, D4] or four [D1-D4] Ig-like domains on the cell surface.


Pssm-ID: 409402 [Multi-domain]  Cd Length: 89  Bit Score: 35.06  E-value: 5.77e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 124248497 110 ISILNVTLNDTGTYECEVtrffefdSFKLSANKNIRINLKVN 151
Cdd:cd05740   55 LTLLNVTREDAGAYQCEI-------SNPVSANRSDPVTLDVI 89
I-set pfam07679
Immunoglobulin I-set domain;
29-128 8.44e-03

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 34.54  E-value: 8.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124248497   29 VPSDGEAIVGKVKKLTCiycmkreEILATT--KVEWFYKGQDKNKTRTLIYLYDGepqepkdvdeqwkgrvtwtgskdmQ 106
Cdd:pfam07679   6 KPKDVEVQEGESARFTC-------TVTGTPdpEVSWFKDGQPLRSSDRFKVTYEG------------------------G 54

                          90       100
                  ....*....|....*....|..
gi 124248497  107 DVSISILNVTLNDTGTYECEVT 128
Cdd:pfam07679  55 TYTLTISNVQPDDSGKYTCVAT 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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