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Conserved domains on  [gi|124487382|ref|NP_001074473|]
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COMM domain-containing protein 5 [Homo sapiens]

Protein Classification

COMM domain-containing protein 5( domain architecture ID 10140833)

COMM domain-containing protein 5 (COMMD5) may modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes and negatively regulates cell proliferation.

Gene Ontology:  GO:0005515
PubMed:  15799966
SCOP:  4005215

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Commd5_HCaRG cd04753
COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated ...
 115-224 2.79e-64

COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated gene). HCaRG is a nuclear protein that might be involved in cell proliferation; it is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


:

Pssm-ID: 240101  Cd Length: 110  Bit Score: 194.97  E-value: 2.79e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487382 115 ELCIPQDLVGDLASVVFGSQRPLLDSVAQQQGAWLPHVADFRWRVDVAISTSALARSLQPSVLMQLKLSDGSAYRFEVPT 194
Cdd:cd04753    1 ELRIPEELITDLASVVYGQRRPLLESGALQKGVRLPHLEDFKWRVDVAISTSSLSRVLQPSILMEMKLSDGKSHRFEVPV 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 124487382 195 AKFQELRYSVALVLKEMADLEKRCERRLQD 224
Cdd:cd04753   81 AKFHELRYNVALILKEMNDLEKRSILKIQD 110
 
Name Accession Description Interval E-value
Commd5_HCaRG cd04753
COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated ...
 115-224 2.79e-64

COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated gene). HCaRG is a nuclear protein that might be involved in cell proliferation; it is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240101  Cd Length: 110  Bit Score: 194.97  E-value: 2.79e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487382 115 ELCIPQDLVGDLASVVFGSQRPLLDSVAQQQGAWLPHVADFRWRVDVAISTSALARSLQPSVLMQLKLSDGSAYRFEVPT 194
Cdd:cd04753    1 ELRIPEELITDLASVVYGQRRPLLESGALQKGVRLPHLEDFKWRVDVAISTSSLSRVLQPSILMEMKLSDGKSHRFEVPV 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 124487382 195 AKFQELRYSVALVLKEMADLEKRCERRLQD 224
Cdd:cd04753   81 AKFHELRYNVALILKEMNDLEKRSILKIQD 110
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 148-205 7.37e-14

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 64.11  E-value: 7.37e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 124487382  148 WLPHVADFRWRVDVAISTSALARSLQPSVLMQLKLSDGS----AYRFEVPTAKFQELRYSVA 205
Cdd:pfam07258   1 SLPQLVDLDWRLDVQLSSSSLSKVNEPVVLLELKLSDGDgsseEVTFELSKEQLQDLLNELE 62
 
Name Accession Description Interval E-value
Commd5_HCaRG cd04753
COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated ...
 115-224 2.79e-64

COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated gene). HCaRG is a nuclear protein that might be involved in cell proliferation; it is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240101  Cd Length: 110  Bit Score: 194.97  E-value: 2.79e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487382 115 ELCIPQDLVGDLASVVFGSQRPLLDSVAQQQGAWLPHVADFRWRVDVAISTSALARSLQPSVLMQLKLSDGSAYRFEVPT 194
Cdd:cd04753    1 ELRIPEELITDLASVVYGQRRPLLESGALQKGVRLPHLEDFKWRVDVAISTSSLSRVLQPSILMEMKLSDGKSHRFEVPV 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 124487382 195 AKFQELRYSVALVLKEMADLEKRCERRLQD 224
Cdd:cd04753   81 AKFHELRYNVALILKEMNDLEKRSILKIQD 110
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 148-205 7.37e-14

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 64.11  E-value: 7.37e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 124487382  148 WLPHVADFRWRVDVAISTSALARSLQPSVLMQLKLSDGS----AYRFEVPTAKFQELRYSVA 205
Cdd:pfam07258   1 SLPQLVDLDWRLDVQLSSSSLSKVNEPVVLLELKLSDGDgsseEVTFELSKEQLQDLLNELE 62
Commd cd04748
COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene ...
 145-224 1.66e-12

COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. HCaRG, a nuclear protein that might be involved in cell proliferation, is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals.


Pssm-ID: 240096  Cd Length: 87  Bit Score: 61.17  E-value: 1.66e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487382 145 QGAWLPHVADFRWRVDVAISTSALARSLQPSVLMQLKLSDGsayrfevPTAKFQELRYSVALVLKEMaDLEKRCERRLQD 224
Cdd:cd04748   16 QSLSLPQLVDFDWRLDVQISSSSLAKVKQPTILVQLKLQVG-------DNNSSEKICFEMTKEELQN-FLNKLKKIKAQL 87
Commd2 cd04750
COMM_Domain containing protein 2. The COMM Domain is found at the C-terminus of a variety of ...
 50-192 2.26e-07

COMM_Domain containing protein 2. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240098 [Multi-domain]  Cd Length: 166  Bit Score: 48.85  E-value: 2.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487382  50 KLLKFVVSSLQGED----CREAVQRLGVSANLPEEQLGALLAgmhtLLQQALRLpptSLKPDTFRDQLQELCIPQDLVGD 125
Cdd:cd04750    1 EFCKLAIEFLFKGInqkkYEGAARKLEVEVETVQHGVEALVY----LLIESTKL---KLSERDFQDSIEFLGFSDDLNEI 73

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 124487382 126 LASVVFgSQRPLLDSVAQQQGAWLPHVADFRWRVDVAISTSALARSLQPSVLMQLKLSDGSAYRFEV 192
Cdd:cd04750   74 LLQLYE-SNRKEIRNILKELSPDLPHYHNLEWRLDVQIASRSLRSQVKPVITMKLHLEDENKKIETH 139
Commd10 cd04758
COMM_Domain containing protein 10. The COMM Domain is found at the C-terminus of a variety of ...
 39-185 3.24e-06

COMM_Domain containing protein 10. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240106 [Multi-domain]  Cd Length: 186  Bit Score: 45.83  E-value: 3.24e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487382  39 LLGDLDRSTFRKLLKFVVSSLQGEDCR----EAVQRLGVSANLPEEQLGALLAGMHTLLQQALRLpptSLKPDTFRDQLQ 114
Cdd:cd04758    7 LINSIDTEKFPRLLSRLFQKLHLKAERsfseEEEEKLQEAFKLLSQDLKLLLETISFILEQAAYH---NLKPSNLQQQLR 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 124487382 115 ELCIPQDLVGDLASVVFGSQRPLLDSVAQQQGAwlPHV-ADFRWRVDVAISTSALARSLQPSVLMQLKLSDG 185
Cdd:cd04758   84 NILLLEDKASAFVNAWEAEGEDVLEKLRSRILA--PNQlEDVSWRLNLQMSSSTQAKLKSPLAVLELGVTSE 153
Commd1_MURR1 cd04749
COMM_Domain containing protein 1, also called Murr1. Murr1/Commd1 is a protein involved in ...
 48-216 1.01e-05

COMM_Domain containing protein 1, also called Murr1. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240097 [Multi-domain]  Cd Length: 174  Bit Score: 44.42  E-value: 1.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487382  48 FRKLLKFVVSSLQGEDCR--EAVQRLGVSANLPEEQLGALLAGMHTLLQQA------LRLPPTSLKPDTFRdQLQELCIP 119
Cdd:cd04749    1 LSGLLNGIAQKEYYGNAEitEELLRSELYPEDPLEEFRALHNKMRGLLKSIasadmdINQLEAFLTAQTKK-QGGITSLQ 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487382 120 QDLVgdlaSVVFGSQRPLLDSVAQQQGAWLPHVADFRWRVDVAISTSALARSLQPSVLMQLKL----SDGSAYRFEVPTA 195
Cdd:cd04749   80 AAVI----AKFWKVHKKKIRESLLAQSRWENSLRGLSWRVDLKTQSRHIAQINSPVAIVELELgktgQESEFVCLEFDEA 155

                        170       180
                 ....*....|....*....|.
gi 124487382 196 KfqelrysVALVLKEMADLEK 216
Cdd:cd04749  156 K-------VNRVLKQLAEIQE 169
Commd9 cd04757
COMM_Domain containing protein 9. The COMM Domain is found at the C-terminus of a variety of ...
 140-187 6.31e-05

COMM_Domain containing protein 9. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240105  Cd Length: 108  Bit Score: 41.01  E-value: 6.31e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 124487382 140 SVAQQQGAWLPHVADFRWRVDVAISTSALARSLQPSVLMQLKLSDGSA 187
Cdd:cd04757   22 SEASENQISLPKLVDHDWRVDIKTSSDSLGRMAVPTCLLQMKIQEAPS 69
Commd4 cd04752
COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of ...
 55-202 5.80e-04

COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240100 [Multi-domain]  Cd Length: 174  Bit Score: 39.33  E-value: 5.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487382  55 VVSSLQGEDCR-EAVQRLGVSANLPEEQLGALLAGMHTLLQQALRlppTSLKPDTFRDQLQELCIPQDLVGDLaSVVFGS 133
Cdd:cd04752   13 VLKDLLGEGIDyEKVLKLTADAKFESGDVKASIAVLSFILSSAAK---YNVDGESLSSELQQLGLPKEHATSL-CRSYEE 88

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 124487382 134 QRPLLDSVAQQQGAWLPHVADFRWRVDVAISTSALARSLQPSVLMQLKLSDGS-----AYRFEVPTAKFQELRY 202
Cdd:cd04752   89 KQSKLQESLRANSLRLSRLESVDWRVDYILSSSELQEVNEPLVQLRLKVRNADtgeitPHPFSVSADKFRVLLA 162
Commd3 cd04751
COMM_Domain containing protein 3. The COMM Domain is found at the C-terminus of a variety of ...
 135-220 8.60e-04

COMM_Domain containing protein 3. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240099  Cd Length: 95  Bit Score: 37.33  E-value: 8.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487382 135 RPLLDSVaqqqGAWLPHVADFRWRVDVAISTSALARSLQPSVLMQLKLSDGSAY---RFEVPTAKFQELRYSvalvLKEM 211
Cdd:cd04751   15 ENKLKSI----GISFPHITDVNWRLDYVVSSKHLGKVNQPIYLIQLSTENGENKpdiNFTCTLEQLQDLVNK----LKDA 86


                 ....*....
gi 124487382 212 AdleKRCER 220
Cdd:cd04751   87 A---KNIER 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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