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Conserved domains on  [gi|55743075|ref|NP_001078|]
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angio-associated migratory cell protein isoform 2 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10078108)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; similar to Homo sapiens angio-associated migratory cell protein that plays a role in angiogenesis and cell migration

Gene Ontology:  GO:0005515
PubMed:  10322433

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 86-386 2.66e-60

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 197.94  E-value: 2.66e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743075  86 TFALHSASVFCVSLDPKTNTLAvTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDT 165
Cdd:cd00200   4 TLKGHTGGVTCVAFSPDGKLLA-TGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743075 166 KEEVWSFE--AGDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGDCK-TFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIW 242
Cdd:cd00200  83 GECVRTLTghTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLtTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743075 243 DLKQGSPIHVLkgtEGHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVAsqpslgegeesesnsves 322
Cdd:cd00200 163 DLRTGKCVATL---TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENG------------------ 221

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 55743075 323 LGFCSVMP---LAAVGYLDGTLAIYDLATQTLRHQCQ-HQSGIVQLLWEAGTAVVYTCSLDGIVRLWD 386
Cdd:cd00200 222 VNSVAFSPdgyLLASGSEDGTIRVWDLRTGECVQTLSgHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 389-427 1.07e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


:

Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 1.07e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 55743075    389 TGRLLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKVF 427
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 86-386 2.66e-60

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 197.94  E-value: 2.66e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743075  86 TFALHSASVFCVSLDPKTNTLAvTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDT 165
Cdd:cd00200   4 TLKGHTGGVTCVAFSPDGKLLA-TGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743075 166 KEEVWSFE--AGDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGDCK-TFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIW 242
Cdd:cd00200  83 GECVRTLTghTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLtTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743075 243 DLKQGSPIHVLkgtEGHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVAsqpslgegeesesnsves 322
Cdd:cd00200 163 DLRTGKCVATL---TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENG------------------ 221

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 55743075 323 LGFCSVMP---LAAVGYLDGTLAIYDLATQTLRHQCQ-HQSGIVQLLWEAGTAVVYTCSLDGIVRLWD 386
Cdd:cd00200 222 VNSVAFSPdgyLLASGSEDGTIRVWDLRTGECVQTLSgHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
86-426 2.66e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 175.10  E-value: 2.66e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743075  86 TFALHSASVFCVSLDPKTNTLAvTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDT 165
Cdd:COG2319  73 TLLGHTAAVLSVAFSPDGRLLA-SASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT 151

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743075 166 KEEVWSFE--AGDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGDC-KTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIW 242
Cdd:COG2319 152 GKLLRTLTghSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLlRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW 231

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743075 243 DLKQGSPIHVLKGtegHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVAsqpslgegeesesnsves 322
Cdd:COG2319 232 DLATGKLLRTLTG---HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG------------------ 290

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743075 323 lgfcsVMPLA--------AVGYLDGTLAIYDLATQTLRHQCQ-HQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLL 393
Cdd:COG2319 291 -----VNSVAfspdgkllASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELL 365

                       330       340       350
                ....*....|....*....|....*....|...
gi 55743075 394 TDYRGHTAEILDFALSKDASLVVTTSGDHKAKV 426
Cdd:COG2319 366 RTLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 123-161 3.60e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 3.60e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 55743075    123 DGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVW 161
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
124-161 2.63e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.63e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 55743075   124 GELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVW 161
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 389-427 1.07e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 1.07e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 55743075    389 TGRLLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKVF 427
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 86-386 2.66e-60

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 197.94  E-value: 2.66e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743075  86 TFALHSASVFCVSLDPKTNTLAvTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDT 165
Cdd:cd00200   4 TLKGHTGGVTCVAFSPDGKLLA-TGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743075 166 KEEVWSFE--AGDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGDCK-TFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIW 242
Cdd:cd00200  83 GECVRTLTghTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLtTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743075 243 DLKQGSPIHVLkgtEGHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVAsqpslgegeesesnsves 322
Cdd:cd00200 163 DLRTGKCVATL---TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENG------------------ 221

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 55743075 323 LGFCSVMP---LAAVGYLDGTLAIYDLATQTLRHQCQ-HQSGIVQLLWEAGTAVVYTCSLDGIVRLWD 386
Cdd:cd00200 222 VNSVAFSPdgyLLASGSEDGTIRVWDLRTGECVQTLSgHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
86-426 2.66e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 175.10  E-value: 2.66e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743075  86 TFALHSASVFCVSLDPKTNTLAvTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDT 165
Cdd:COG2319  73 TLLGHTAAVLSVAFSPDGRLLA-SASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT 151

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743075 166 KEEVWSFE--AGDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGDC-KTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIW 242
Cdd:COG2319 152 GKLLRTLTghSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLlRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW 231

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743075 243 DLKQGSPIHVLKGtegHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVAsqpslgegeesesnsves 322
Cdd:COG2319 232 DLATGKLLRTLTG---HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG------------------ 290

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743075 323 lgfcsVMPLA--------AVGYLDGTLAIYDLATQTLRHQCQ-HQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLL 393
Cdd:COG2319 291 -----VNSVAfspdgkllASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELL 365

                       330       340       350
                ....*....|....*....|....*....|...
gi 55743075 394 TDYRGHTAEILDFALSKDASLVVTTSGDHKAKV 426
Cdd:COG2319 366 RTLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
86-426 6.93e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 155.45  E-value: 6.93e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743075  86 TFALHSASVFCVSLDPkTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDT 165
Cdd:COG2319  31 LLLGLAAAVASLAASP-DGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743075 166 KEEVWSFEA--GDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGDC-KTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIW 242
Cdd:COG2319 110 GLLLRTLTGhtGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLlRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743075 243 DLKQGSPIHVLKgteGHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETvasqpslgegeesesnsvES 322
Cdd:COG2319 190 DLATGKLLRTLT---GHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHS------------------GS 248

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743075 323 LGFCSVMP---LAAVGYLDGTLAIYDLATQTLRHQCQHQSGIVqllweagTAVVY--------TCSLDGIVRLWDARTGR 391
Cdd:COG2319 249 VRSVAFSPdgrLLASGSADGTVRLWDLATGELLRTLTGHSGGV-------NSVAFspdgkllaSGSDDGTVRLWDLATGK 321

                       330       340       350
                ....*....|....*....|....*....|....*
gi 55743075 392 LLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKV 426
Cdd:COG2319 322 LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRL 356
WD40 COG2319
WD40 repeat [General function prediction only];
106-427 2.01e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 137.74  E-value: 2.01e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743075 106 LAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDTKEEVWSFE--AGDLEWMEWH 183
Cdd:COG2319   8 ALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLghTAAVLSVAFS 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743075 184 PRAPVLLAGTADGNTWMWKVPNGDCK-TFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQGSPIHVLKGtegHQGP 262
Cdd:COG2319  88 PDGRLLASASADGTVRLWDLATGLLLrTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG---HSGA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743075 263 LTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVAsqpslgegeesesnsveslgfcsVMPLA--------AV 334
Cdd:COG2319 165 VTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA-----------------------VRSVAfspdgkllAS 221

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743075 335 GYLDGTLAIYDLATQTLRHQCQHQSGIVQ-LLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDAS 413
Cdd:COG2319 222 GSADGTVRLWDLATGKLLRTLTGHSGSVRsVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGK 301

                       330
                ....*....|....
gi 55743075 414 LVVTTSGDHKAKVF 427
Cdd:COG2319 302 LLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 325-430 1.35e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.99  E-value: 1.35e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743075 325 FCSVMPLAAVGYLDGTLAIYDLAT-QTLRHQCQHQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEI 403
Cdd:cd00200  17 FSPDGKLLATGSGDGTIKVWDLETgELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYV 96

                        90       100
                ....*....|....*....|....*..
gi 55743075 404 LDFALSKDASLVVTTSGDHKAKVFCVQ 430
Cdd:cd00200  97 SSVAFSPDGRILSSSSRDKTIKVWDVE 123
WD40 COG2319
WD40 repeat [General function prediction only];
222-430 2.09e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 71.48  E-value: 2.09e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743075 222 RVLPDGKRAVVGYEDGTIRIWDLKQGSPIHVLkgtEGHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPE 301
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLL---LGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGH 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743075 302 TVAsqpslgegeesesnsVESLGFCSVMPLAAVGYLDGTLAIYDLATQTLRHQCQ-HQSGIVQLLWEAGTAVVYTCSLDG 380
Cdd:COG2319  78 TAA---------------VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTgHTGAVRSVAFSPDGKTLASGSADG 142

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 55743075 381 IVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKVFCVQ 430
Cdd:COG2319 143 TVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA 192
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 123-161 3.60e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 3.60e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 55743075    123 DGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVW 161
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
124-161 2.63e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.63e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 55743075   124 GELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVW 161
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 180-266 1.24e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 40.72  E-value: 1.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743075   180 MEWHPRAPVLLAGTADGNTWM--------WKVPNGdcktfqGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQGSPIH 251
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELLLhrlnwqrvWTLSPD------KEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVH 74

                          90
                  ....*....|....*
gi 55743075   252 VLKgteGHQGPLTCV 266
Cdd:pfam12894  75 HFS---AGSDLITCL 86
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 208-243 1.74e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 1.74e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 55743075    208 CKTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWD 243
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 246-286 2.10e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 2.10e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 55743075    246 QGSPIHVLKGtegHQGPLTCVAANQDGSLILTGSVDCQAKL 286
Cdd:smart00320   1 SGELLKTLKG---HTGPVTSVAFSPDGKYLASGSDDGTIKL 38
WD40 pfam00400
WD domain, G-beta repeat;
247-286 4.41e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 4.41e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 55743075   247 GSPIHVLKGtegHQGPLTCVAANQDGSLILTGSVDCQAKL 286
Cdd:pfam00400   1 GKLLKTLEG---HTGSVTSLAFSPDGKLLASGSDDGTVKV 37
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 389-427 1.07e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 1.07e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 55743075    389 TGRLLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKVF 427
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
209-243 3.04e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 3.04e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 55743075   209 KTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWD 243
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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