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Conserved domains on  [gi|146134517|ref|NP_001078887|]
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preferentially expressed antigen in melanoma like 5 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1001123)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; similar to Oryctolagus cuniculus monocyte differentiation antigen CD14, a coreceptor for bacterial lipopolysaccharide

Gene Ontology:  GO:0005515
PubMed:  11751054

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
146-410 1.98e-07

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.40  E-value: 1.98e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134517 146 TITIKMNLSLKYCRHSKYLNYLHWWAEQRKDGIQVICEKLEFTGPHCPELRFLKFSFVASIQELAIKSIHWDIYNLALIA 225
Cdd:COG4886   10 LKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134517 226 SCLGQMKNLQKLILMNIRRPPDLADLQEAHI----VTEIFSEFSKLHKVHYLHV--NNVYFLKERLDQMLRcferpLETL 299
Cdd:COG4886   90 TDLGDLTNLTELDLSGNEELSNLTNLESLDLsgnqLTDLPEELANLTNLKELDLsnNQLTDLPEPLGNLTN-----LKSL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134517 300 AITHCRLSELDmRYLSQCPsihQLKYLDMSYTtfkpsshrflgsLLERLTATLQTLK-LECFHLTDFQIRDLLPGLSQCS 378
Cdd:COG4886  165 DLSNNQLTDLP-EELGNLT---NLKELDLSNN------------QITDLPEPLGNLTnLEELDLSGNQLTDLPEPLANLT 228

                        250       260       270
                 ....*....|....*....|....*....|...
gi 146134517 379 QLTEVDIAMNEFSVV-SLKKLlkhtANLTQLTL 410
Cdd:COG4886  229 NLETLDLSNNQLTDLpELGNL----TNLEELDL 257
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
146-410 1.98e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.40  E-value: 1.98e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134517 146 TITIKMNLSLKYCRHSKYLNYLHWWAEQRKDGIQVICEKLEFTGPHCPELRFLKFSFVASIQELAIKSIHWDIYNLALIA 225
Cdd:COG4886   10 LKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134517 226 SCLGQMKNLQKLILMNIRRPPDLADLQEAHI----VTEIFSEFSKLHKVHYLHV--NNVYFLKERLDQMLRcferpLETL 299
Cdd:COG4886   90 TDLGDLTNLTELDLSGNEELSNLTNLESLDLsgnqLTDLPEELANLTNLKELDLsnNQLTDLPEPLGNLTN-----LKSL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134517 300 AITHCRLSELDmRYLSQCPsihQLKYLDMSYTtfkpsshrflgsLLERLTATLQTLK-LECFHLTDFQIRDLLPGLSQCS 378
Cdd:COG4886  165 DLSNNQLTDLP-EELGNLT---NLKELDLSNN------------QITDLPEPLGNLTnLEELDLSGNQLTDLPEPLANLT 228

                        250       260       270
                 ....*....|....*....|....*....|...
gi 146134517 379 QLTEVDIAMNEFSVV-SLKKLlkhtANLTQLTL 410
Cdd:COG4886  229 NLETLDLSNNQLTDLpELGNL----TNLEELDL 257
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 233-391 5.07e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.45  E-value: 5.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134517 233 NLQKLIL----MNIRRPPDLAD--------LQEAHIVTEIFSEFSKLHKVHYLHV--NNvyfLKERLDQmlRCFERP-LE 297
Cdd:PLN00113 381 NLFKLILfsnsLEGEIPKSLGAcrslrrvrLQDNSFSGELPSEFTKLPLVYFLDIsnNN---LQGRINS--RKWDMPsLQ 455

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134517 298 TLAITHCRLS-ELDMRYLSQcpsihQLKYLDMSYTTFKPSSHRFLGSLLErltatLQTLKlecfhLTDFQIRDLLPG-LS 375
Cdd:PLN00113 456 MLSLARNKFFgGLPDSFGSK-----RLENLDLSRNQFSGAVPRKLGSLSE-----LMQLK-----LSENKLSGEIPDeLS 520

                        170
                 ....*....|....*.
gi 146134517 376 QCSQLTEVDIAMNEFS 391
Cdd:PLN00113 521 SCKKLVSLDLSHNQLS 536
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
146-410 1.98e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.40  E-value: 1.98e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134517 146 TITIKMNLSLKYCRHSKYLNYLHWWAEQRKDGIQVICEKLEFTGPHCPELRFLKFSFVASIQELAIKSIHWDIYNLALIA 225
Cdd:COG4886   10 LKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134517 226 SCLGQMKNLQKLILMNIRRPPDLADLQEAHI----VTEIFSEFSKLHKVHYLHV--NNVYFLKERLDQMLRcferpLETL 299
Cdd:COG4886   90 TDLGDLTNLTELDLSGNEELSNLTNLESLDLsgnqLTDLPEELANLTNLKELDLsnNQLTDLPEPLGNLTN-----LKSL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134517 300 AITHCRLSELDmRYLSQCPsihQLKYLDMSYTtfkpsshrflgsLLERLTATLQTLK-LECFHLTDFQIRDLLPGLSQCS 378
Cdd:COG4886  165 DLSNNQLTDLP-EELGNLT---NLKELDLSNN------------QITDLPEPLGNLTnLEELDLSGNQLTDLPEPLANLT 228

                        250       260       270
                 ....*....|....*....|....*....|...
gi 146134517 379 QLTEVDIAMNEFSVV-SLKKLlkhtANLTQLTL 410
Cdd:COG4886  229 NLETLDLSNNQLTDLpELGNL----TNLEELDL 257
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
161-413 2.76e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 40.30  E-value: 2.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134517 161 SKYLNYLHWWAEQRKDGIQVICEKLEFTGPHCPELRFLKFSFVASIQELA-IKSIHWDIYNLALIASCLGQMKNLQKLIL 239
Cdd:COG4886   64 SLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTnLESLDLSGNQLTDLPEELANLTNLKELDL 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134517 240 --MNIRR-PPDLADLQEAHI-------VTEIFSEFSKLHKVHYLHV--NNVYFLKERLDQMLRcferpLETLAITHCRLS 307
Cdd:COG4886  144 snNQLTDlPEPLGNLTNLKSldlsnnqLTDLPEELGNLTNLKELDLsnNQITDLPEPLGNLTN-----LEELDLSGNQLT 218

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134517 308 ELDmRYLSQCPSihqLKYLDMSYTTFK--PSshrfLGSL--LERLT---------------ATLQTLKLECFHLTDFQIR 368
Cdd:COG4886  219 DLP-EPLANLTN---LETLDLSNNQLTdlPE----LGNLtnLEELDlsnnqltdlpplanlTNLKTLDLSNNQLTDLKLK 290

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 146134517 369 DLLPGLSQCSQLTEVDIAMNEFSVVSLKKLLKHTANLTQLTLEKY 413
Cdd:COG4886  291 ELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLV 335
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 233-391 5.07e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.45  E-value: 5.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134517 233 NLQKLIL----MNIRRPPDLAD--------LQEAHIVTEIFSEFSKLHKVHYLHV--NNvyfLKERLDQmlRCFERP-LE 297
Cdd:PLN00113 381 NLFKLILfsnsLEGEIPKSLGAcrslrrvrLQDNSFSGELPSEFTKLPLVYFLDIsnNN---LQGRINS--RKWDMPsLQ 455

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134517 298 TLAITHCRLS-ELDMRYLSQcpsihQLKYLDMSYTTFKPSSHRFLGSLLErltatLQTLKlecfhLTDFQIRDLLPG-LS 375
Cdd:PLN00113 456 MLSLARNKFFgGLPDSFGSK-----RLENLDLSRNQFSGAVPRKLGSLSE-----LMQLK-----LSENKLSGEIPDeLS 520

                        170
                 ....*....|....*.
gi 146134517 376 QCSQLTEVDIAMNEFS 391
Cdd:PLN00113 521 SCKKLVSLDLSHNQLS 536
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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