NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|148612833|ref|NP_001091980|]
View 

E3 ubiquitin-protein ligase pellino homolog 3 isoform 2 [Homo sapiens]

Protein Classification

E3 ubiquitin-protein ligase pellino family protein( domain architecture ID 10520238)

E3 ubiquitin-protein ligase pellino family protein which catalyzes the covalent attachment of ubiquitin moieties onto substrate proteins, and is involved in the TLR and IL-1 signaling pathways; similar to human E3 ubiquitin-protein ligase pellino homolog 1 (pellino-1)

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Pellino pfam04710
Pellino; Pellino is involved in Toll-like signalling pathways, and associates with the kinase ...
 37-445 0e+00

Pellino; Pellino is involved in Toll-like signalling pathways, and associates with the kinase domain of the Pelle Ser/Thr kinase.


:

Pssm-ID: 461403  Cd Length: 409  Bit Score: 805.41  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612833   37 PGEEPIKYGELIVLGYNGCLASGDKGRRRSRLALSRRSHANGVKPDVMHHISTPLVSKALSNRGQHSISYTLSRSHSVIV 116
Cdd:pfam04710   1 PSKEPIKYGELVILGYNGSLPNGDKGRRRSKFVLYKRPKANGVKPSKHHIVKTPQASKAILDKGQHSISYTLSRNQAVVV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612833  117 EYTHDSDTDMFQIGRSTENMIDFVVTDTSPGGG-AAEGPSAQSTISRYACRILCDRRPPYTARIYAAGFDASSNIFLGER 195
Cdd:pfam04710  81 EYTHDEDTDMFQIGRSSESPIDFVVMDTVPGDKtGEETQVAQSTISRFACRILVDRNPPYTARIYAAGFDSSKNIFLGEK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612833  196 AAKWRTPDGLMDGLTTNGVLVMHPAGGFSEDSAPGVWREISVCGNVYTLRDSRSAQQRGKLVENESNVLQDGSLIDLCGA 275
Cdd:pfam04710 161 ATKWKTPDGEMDGLTTNGVLIMHPRGGFCEDSKPGVWREVSVCGGVYSLRETRSAQQKGKLVENESNILQDGTLIDLCGA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612833  276 TLLWRTPAGLLRAPTLKQLEAQRQEANAARPQCPVGLSTLAFPSPARGRTAPDKQQPWVYVRCGHVHGYHGWGCRRERGP 355
Cdd:pfam04710 241 TLLWRSAEGLLRSPTLKHLEALRDEINAGRPQCPVGLNTLVFPRKSRGRSSEEEKQPYVYLNCGHVHGYHDWGQKEESGA 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612833  356 QeRECPLCRLVGPYVPLWLGQEAGLCLDPGPPSHAFAPCGHVCSEKTARYWAQTPLPHGTHAFHAACPFCGAWLTGEHGC 435
Cdd:pfam04710 321 R-RECPMCREVGPYVPLWMGCEPAFYVDSGPPTHAFNPCGHVCSEKTVRYWSQIPLPHGTHAFHAACPFCATPLTGEPGY 399

                         410
                  ....*....|
gi 148612833  436 VRLIFQGPLD 445
Cdd:pfam04710 400 VKLIFQDNVD 409
 
Name Accession Description Interval E-value
Pellino pfam04710
Pellino; Pellino is involved in Toll-like signalling pathways, and associates with the kinase ...
 37-445 0e+00

Pellino; Pellino is involved in Toll-like signalling pathways, and associates with the kinase domain of the Pelle Ser/Thr kinase.


Pssm-ID: 461403  Cd Length: 409  Bit Score: 805.41  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612833   37 PGEEPIKYGELIVLGYNGCLASGDKGRRRSRLALSRRSHANGVKPDVMHHISTPLVSKALSNRGQHSISYTLSRSHSVIV 116
Cdd:pfam04710   1 PSKEPIKYGELVILGYNGSLPNGDKGRRRSKFVLYKRPKANGVKPSKHHIVKTPQASKAILDKGQHSISYTLSRNQAVVV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612833  117 EYTHDSDTDMFQIGRSTENMIDFVVTDTSPGGG-AAEGPSAQSTISRYACRILCDRRPPYTARIYAAGFDASSNIFLGER 195
Cdd:pfam04710  81 EYTHDEDTDMFQIGRSSESPIDFVVMDTVPGDKtGEETQVAQSTISRFACRILVDRNPPYTARIYAAGFDSSKNIFLGEK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612833  196 AAKWRTPDGLMDGLTTNGVLVMHPAGGFSEDSAPGVWREISVCGNVYTLRDSRSAQQRGKLVENESNVLQDGSLIDLCGA 275
Cdd:pfam04710 161 ATKWKTPDGEMDGLTTNGVLIMHPRGGFCEDSKPGVWREVSVCGGVYSLRETRSAQQKGKLVENESNILQDGTLIDLCGA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612833  276 TLLWRTPAGLLRAPTLKQLEAQRQEANAARPQCPVGLSTLAFPSPARGRTAPDKQQPWVYVRCGHVHGYHGWGCRRERGP 355
Cdd:pfam04710 241 TLLWRSAEGLLRSPTLKHLEALRDEINAGRPQCPVGLNTLVFPRKSRGRSSEEEKQPYVYLNCGHVHGYHDWGQKEESGA 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612833  356 QeRECPLCRLVGPYVPLWLGQEAGLCLDPGPPSHAFAPCGHVCSEKTARYWAQTPLPHGTHAFHAACPFCGAWLTGEHGC 435
Cdd:pfam04710 321 R-RECPMCREVGPYVPLWMGCEPAFYVDSGPPTHAFNPCGHVCSEKTVRYWSQIPLPHGTHAFHAACPFCATPLTGEPGY 399

                         410
                  ....*....|
gi 148612833  436 VRLIFQGPLD 445
Cdd:pfam04710 400 VKLIFQDNVD 409
 
Name Accession Description Interval E-value
Pellino pfam04710
Pellino; Pellino is involved in Toll-like signalling pathways, and associates with the kinase ...
 37-445 0e+00

Pellino; Pellino is involved in Toll-like signalling pathways, and associates with the kinase domain of the Pelle Ser/Thr kinase.


Pssm-ID: 461403  Cd Length: 409  Bit Score: 805.41  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612833   37 PGEEPIKYGELIVLGYNGCLASGDKGRRRSRLALSRRSHANGVKPDVMHHISTPLVSKALSNRGQHSISYTLSRSHSVIV 116
Cdd:pfam04710   1 PSKEPIKYGELVILGYNGSLPNGDKGRRRSKFVLYKRPKANGVKPSKHHIVKTPQASKAILDKGQHSISYTLSRNQAVVV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612833  117 EYTHDSDTDMFQIGRSTENMIDFVVTDTSPGGG-AAEGPSAQSTISRYACRILCDRRPPYTARIYAAGFDASSNIFLGER 195
Cdd:pfam04710  81 EYTHDEDTDMFQIGRSSESPIDFVVMDTVPGDKtGEETQVAQSTISRFACRILVDRNPPYTARIYAAGFDSSKNIFLGEK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612833  196 AAKWRTPDGLMDGLTTNGVLVMHPAGGFSEDSAPGVWREISVCGNVYTLRDSRSAQQRGKLVENESNVLQDGSLIDLCGA 275
Cdd:pfam04710 161 ATKWKTPDGEMDGLTTNGVLIMHPRGGFCEDSKPGVWREVSVCGGVYSLRETRSAQQKGKLVENESNILQDGTLIDLCGA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612833  276 TLLWRTPAGLLRAPTLKQLEAQRQEANAARPQCPVGLSTLAFPSPARGRTAPDKQQPWVYVRCGHVHGYHGWGCRRERGP 355
Cdd:pfam04710 241 TLLWRSAEGLLRSPTLKHLEALRDEINAGRPQCPVGLNTLVFPRKSRGRSSEEEKQPYVYLNCGHVHGYHDWGQKEESGA 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612833  356 QeRECPLCRLVGPYVPLWLGQEAGLCLDPGPPSHAFAPCGHVCSEKTARYWAQTPLPHGTHAFHAACPFCGAWLTGEHGC 435
Cdd:pfam04710 321 R-RECPMCREVGPYVPLWMGCEPAFYVDSGPPTHAFNPCGHVCSEKTVRYWSQIPLPHGTHAFHAACPFCATPLTGEPGY 399

                         410
                  ....*....|
gi 148612833  436 VRLIFQGPLD 445
Cdd:pfam04710 400 VKLIFQDNVD 409
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH