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Conserved domains on  [gi|148886760|ref|NP_001092092|]
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nanos homolog 3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-nanos pfam05741
Nanos RNA binding domain; This family consists of several conserved novel zinc finger domains ...
 77-130 1.19e-32

Nanos RNA binding domain; This family consists of several conserved novel zinc finger domains found in the eukaryotic proteins Nanos and Xcat-2. In Drosophila melanogaster, Nanos functions as a localized determinant of posterior pattern. Nanos RNA is localized to the posterior pole of the maturing egg cell and encodes a protein that emanates from this localized source. Nanos acts as a translational repressor and thereby establishes a gradient of the morphogen Hunchback. Xcat-2 is found in the vegetal cortical region and is inherited by the vegetal blasomeres during development, and is degraded very early in development. The localized and maternally restricted expression of Xcat-2 RNA suggests a role for its protein in setting up regional differences in gene expression that occur early in development.


:

Pssm-ID: 461728  Cd Length: 54  Bit Score: 111.51  E-value: 1.19e-32
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 148886760   77 CSFCKHNGESRAIYQSHVLKDEAGRVLCPILRDYVCPQCGATRERAHTRRFCPL 130
Cdd:pfam05741   1 CVFCKNNGESREVYSSHTLKDPDGRVTCPVLRKYVCPICGATGDNAHTIKYCPK 54
Trypan_PARP super family cl42451
Procyclic acidic repetitive protein (PARP); This family consists of several Trypanosoma brucei ...
 23-74 1.49e-06

Procyclic acidic repetitive protein (PARP); This family consists of several Trypanosoma brucei procyclic acidic repetitive protein (PARP) like sequences. The procyclic acidic repetitive protein (parp) genes of Trypanosoma brucei encode a small family of abundant surface proteins whose expression is restricted to the procyclic form of the parasite. They are found at two unlinked loci, parpA and parpB; transcription of both loci is developmentally regulated.


The actual alignment was detected with superfamily member pfam05887:

Pssm-ID: 368653  Cd Length: 134  Bit Score: 45.55  E-value: 1.49e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 148886760   23 KEGPETRLSPQPEPEPMLEPVSALEPMPAPESVPVPGPKDqkrslESSPAPE 74
Cdd:pfam05887  64 EPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEP-----EPEPEPE 110
 
Name Accession Description Interval E-value
zf-nanos pfam05741
Nanos RNA binding domain; This family consists of several conserved novel zinc finger domains ...
 77-130 1.19e-32

Nanos RNA binding domain; This family consists of several conserved novel zinc finger domains found in the eukaryotic proteins Nanos and Xcat-2. In Drosophila melanogaster, Nanos functions as a localized determinant of posterior pattern. Nanos RNA is localized to the posterior pole of the maturing egg cell and encodes a protein that emanates from this localized source. Nanos acts as a translational repressor and thereby establishes a gradient of the morphogen Hunchback. Xcat-2 is found in the vegetal cortical region and is inherited by the vegetal blasomeres during development, and is degraded very early in development. The localized and maternally restricted expression of Xcat-2 RNA suggests a role for its protein in setting up regional differences in gene expression that occur early in development.


Pssm-ID: 461728  Cd Length: 54  Bit Score: 111.51  E-value: 1.19e-32
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 148886760   77 CSFCKHNGESRAIYQSHVLKDEAGRVLCPILRDYVCPQCGATRERAHTRRFCPL 130
Cdd:pfam05741   1 CVFCKNNGESREVYSSHTLKDPDGRVTCPVLRKYVCPICGATGDNAHTIKYCPK 54
Trypan_PARP pfam05887
Procyclic acidic repetitive protein (PARP); This family consists of several Trypanosoma brucei ...
 23-74 1.49e-06

Procyclic acidic repetitive protein (PARP); This family consists of several Trypanosoma brucei procyclic acidic repetitive protein (PARP) like sequences. The procyclic acidic repetitive protein (parp) genes of Trypanosoma brucei encode a small family of abundant surface proteins whose expression is restricted to the procyclic form of the parasite. They are found at two unlinked loci, parpA and parpB; transcription of both loci is developmentally regulated.


Pssm-ID: 368653  Cd Length: 134  Bit Score: 45.55  E-value: 1.49e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 148886760   23 KEGPETRLSPQPEPEPMLEPVSALEPMPAPESVPVPGPKDqkrslESSPAPE 74
Cdd:pfam05887  64 EPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEP-----EPEPEPE 110
PRK10819 PRK10819
transport protein TonB; Provisional
 26-61 5.62e-03

transport protein TonB; Provisional


Pssm-ID: 236768 [Multi-domain]  Cd Length: 246  Bit Score: 36.58  E-value: 5.62e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 148886760  26 PETRLSPQPEPEPMLEP-VSALEPMPAPESVPVPGPK 61
Cdd:PRK10819  68 PEPVVEPEPEPEPIPEPpKEAPVVIPKPEPKPKPKPK 104
 
Name Accession Description Interval E-value
zf-nanos pfam05741
Nanos RNA binding domain; This family consists of several conserved novel zinc finger domains ...
 77-130 1.19e-32

Nanos RNA binding domain; This family consists of several conserved novel zinc finger domains found in the eukaryotic proteins Nanos and Xcat-2. In Drosophila melanogaster, Nanos functions as a localized determinant of posterior pattern. Nanos RNA is localized to the posterior pole of the maturing egg cell and encodes a protein that emanates from this localized source. Nanos acts as a translational repressor and thereby establishes a gradient of the morphogen Hunchback. Xcat-2 is found in the vegetal cortical region and is inherited by the vegetal blasomeres during development, and is degraded very early in development. The localized and maternally restricted expression of Xcat-2 RNA suggests a role for its protein in setting up regional differences in gene expression that occur early in development.


Pssm-ID: 461728  Cd Length: 54  Bit Score: 111.51  E-value: 1.19e-32
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 148886760   77 CSFCKHNGESRAIYQSHVLKDEAGRVLCPILRDYVCPQCGATRERAHTRRFCPL 130
Cdd:pfam05741   1 CVFCKNNGESREVYSSHTLKDPDGRVTCPVLRKYVCPICGATGDNAHTIKYCPK 54
Trypan_PARP pfam05887
Procyclic acidic repetitive protein (PARP); This family consists of several Trypanosoma brucei ...
 23-74 1.49e-06

Procyclic acidic repetitive protein (PARP); This family consists of several Trypanosoma brucei procyclic acidic repetitive protein (PARP) like sequences. The procyclic acidic repetitive protein (parp) genes of Trypanosoma brucei encode a small family of abundant surface proteins whose expression is restricted to the procyclic form of the parasite. They are found at two unlinked loci, parpA and parpB; transcription of both loci is developmentally regulated.


Pssm-ID: 368653  Cd Length: 134  Bit Score: 45.55  E-value: 1.49e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 148886760   23 KEGPETRLSPQPEPEPMLEPVSALEPMPAPESVPVPGPKDqkrslESSPAPE 74
Cdd:pfam05887  64 EPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEP-----EPEPEPE 110
Trypan_PARP pfam05887
Procyclic acidic repetitive protein (PARP); This family consists of several Trypanosoma brucei ...
 26-74 1.92e-04

Procyclic acidic repetitive protein (PARP); This family consists of several Trypanosoma brucei procyclic acidic repetitive protein (PARP) like sequences. The procyclic acidic repetitive protein (parp) genes of Trypanosoma brucei encode a small family of abundant surface proteins whose expression is restricted to the procyclic form of the parasite. They are found at two unlinked loci, parpA and parpB; transcription of both loci is developmentally regulated.


Pssm-ID: 368653  Cd Length: 134  Bit Score: 39.78  E-value: 1.92e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 148886760   26 PETRLSPQPEPEPMLEPVSALEPMPAPESVPVPGPKDQKrslESSPAPE 74
Cdd:pfam05887  59 PEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEP---EPEPEPE 104
PRK10819 PRK10819
transport protein TonB; Provisional
 26-61 5.62e-03

transport protein TonB; Provisional


Pssm-ID: 236768 [Multi-domain]  Cd Length: 246  Bit Score: 36.58  E-value: 5.62e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 148886760  26 PETRLSPQPEPEPMLEP-VSALEPMPAPESVPVPGPK 61
Cdd:PRK10819  68 PEPVVEPEPEPEPIPEPpKEAPVVIPKPEPKPKPKPK 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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