|
Name |
Accession |
Description |
Interval |
E-value |
| Ten_N super family |
cl24184 |
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of ... |
11-340 |
1.63e-157 |
|
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of the Teneurin family of proteins. These proteins are 'pair-rule' genes and are involved in tissue patterning, specifically probably neural patterning. The intracellular domain is cleaved in response to homophilic interaction of the extracellular domain, and translocates to the nucleus. Here it probably carries out to some transcriptional regulatory activity. The length of this region and the conservation suggests that there may be two structural domains here (personal obs:C Yeats).
The actual alignment was detected with superfamily member pfam06484:
Pssm-ID: 461932 [Multi-domain] Cd Length: 367 Bit Score: 492.57 E-value: 1.63e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 11 SLT-RRRDAERRYTSSSADSEEGKAP-QKSYSSSETLKAYDQDARLAYGSRVKDIVPQEAEEFCRTGANFTLRELGLEEV 88
Cdd:pfam06484 1 SLTkRRRDKERRYTSSSADSEECRVPtQKSYSSSETLKAFDHDSRMLYGNRVKDMVHKEADEFSRQGQNFSLRELGICEP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 89 TPPHGTLYRTDIGLPHCGYSMGAGSDADMEADTVLSPEHPVRLWGRSTRSGRSSCLSSRANSNLTLTDTEHENTETDHPG 168
Cdd:pfam06484 81 SPRHGLAYCTEMGLPHRGYSISTGSDADTETDGPMSPEHAVRLWGRGTKSGRSSCLSSRSNSALTLTDTEHENKSDNENG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 169 ----------------------------------------------------------------------GLQNHARLRT 178
Cdd:pfam06484 161 ppippsssssspveqhsppppslnenqrpllgnnashpildsdpdeefspnsylvrtgsgpqsapseqppNFQNHSRLRT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 179 PPPPLSHAHTPNQHHAASINSLNRGNFTPRSNPSPAPTdHSLSGEPPAggAQEPAHAQENWLLNSNIPLETRnlgkqpfl 258
Cdd:pfam06484 241 PPPPLPPPHKQNQHHHPSINSLNRSSLTNRRNPSPAPT-ASLPAELQS--TQESVQLQDSWVLNSNVPLETR-------- 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 259 gtlqdnliemdilgasrhdgaysdgHFLFKPG-GTSPLFCTTSPGYPLTSSTVYSPPPRPLPRSTFARPAFNLKKPSKYC 337
Cdd:pfam06484 310 -------------------------HFLFKTGtGTTPLFCTASPGYPLTSGTVYSPPPRPLPRNTFSRPAFKLKKPYKYC 364
|
...
gi 169790825 338 NWK 340
Cdd:pfam06484 365 SWK 367
|
|
| NHL super family |
cl18310 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1222-1563 |
4.06e-46 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
The actual alignment was detected with superfamily member cd14953:
Pssm-ID: 302697 [Multi-domain] Cd Length: 323 Bit Score: 170.02 E-value: 4.06e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1222 GLADGNKLLA----PVALTCGSDGSLYVGDF--NYIRRIFPSGNVTNILELRNKDFRHSHSPAHKYY----LATDPmSGA 1291
Cdd:cd14953 11 GFSGGGGTAArfnsPSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAGTGTAGFADGGGAAAQFNtpsgVAVDA-AGN 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1292 VFLSDSNSRRVFKIKSTVVVKdlvknseVVAGTGDQclpfddtRCGDGGKATEATLTNPRGITVDKFGLIYFVDGT--MI 1369
Cdd:cd14953 90 LYVADTGNHRIRKITPDGVVS-------TLAGTGTA-------GFSDDGGATAAQFNYPTGVAVDAAGNLYVADTGnhRI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1370 RRIDQNGIISTLLGsndlTSARPLSCDSVMdiSQVHLEWPTDLAINPMDNsLYVLD--NNVVLQISENHQVRIVAGRpmh 1447
Cdd:cd14953 156 RKITPDGVVTTVAG----TGGAGYAGDGPA--TAAQFNNPTGVAVDAAGN-LYVADrgNHRIRKITPDGVVTTVAGT--- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1448 cqvpGIDHFLLSKVAIHATLESATALAVSHNGVLYIAETDEkkiNRIRQVTTSGEISLVAGAPSGcdckndancdcFSGD 1527
Cdd:cd14953 226 ----GTAGFSGDGGATAAQLNNPTGVAVDAAGNLYVADSGN---HRIRKITPAGVVTTVAGGGAG-----------FSGD 287
|
330 340 350
....*....|....*....|....*....|....*.
gi 169790825 1528 DGYAKDAKLNTPSSLAVCADGELYVADLGNIRIRFI 1563
Cdd:cd14953 288 GGPATSAQFNNPTGVAVDAAGNLYVADTGNNRIRKI 323
|
|
| Tox-GHH |
pfam15636 |
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ... |
2685-2762 |
3.23e-38 |
|
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.
:
Pssm-ID: 464783 Cd Length: 78 Bit Score: 138.13 E-value: 3.23e-38
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 169790825 2685 EEKARVLELARQRAVRQAWAREQQRLREGEEGLRAWTEGEKQQVLSTGRVQGYDGFFVISVEQYPELSDSANNIHFMR 2762
Cdd:pfam15636 1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
1587-2461 |
1.02e-33 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
:
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 142.97 E-value: 1.02e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1587 YLFDTTGKHLYTQSLPTGDYLYNFTYTGDGDITLITDNNGNMVNVRRDSTGMPLWLVVPDGQVYWVTMGTNSALKSVTTQ 1666
Cdd:COG3209 185 GTGAVTLATGLAGSALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAATVTGSATGAAGAGAAVATAATTLGGTTG 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1667 GHELAMMTYHGNSGLLATKSNENgWTTFYEYDSFGRLTNVTFPTGQVSSFRSDTDSSVHVQVETSSKDDVTITTNLSASG 1746
Cdd:COG3209 265 AGTGASGAGLDASTGTGGAGGSN-AAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAVSGAADAGTTTTTGTGTG 343
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1747 AFYTLLQDQVRNSYYIGADGSLRLLLANGMEVALQTEPHLLAGTVNPTVGKRNVTLPIDNGLNLVEWRQRKEQARGQVTV 1826
Cdd:COG3209 344 GTTTTVGGGGSLTLGGYGAAGGLTTSVGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAA 423
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1827 FGRRLRVHNRNLLSLDFDRVTRTEKIYDDHRKFTLRILYDQAGRPSLWSPSSRLNGVNVTYSPGGYIAGIQRGIMSERME 1906
Cdd:COG3209 424 GALTAGGTATGTGTGGGGTTAGTDATTTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLD 503
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1907 YDQAGRITSRIFADGKTWSYTYLEksmVLLLHSQRQYIFEFDKNDRLSSVTMPNVARQTLETIRSVGYYRNIYQPPEGNA 1986
Cdd:COG3209 504 DTLGGTTTTTAGARGLVVTTGTTL---TLGTTTTATLSATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGAST 580
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1987 SVIQDFTEDGHLLHTFYLGTGRRVIYKYGKLSKLAETLYDTTKVSFTYDETAGMLKTINLQNEGFTCTIRYRQIGPLIDR 2066
Cdd:COG3209 581 TTGTTGGTATTTTVTTTTTTSTAGTTTTTTSGYTRAGLTLTLGTGTASGLERATASTGSTTGGTTGTGVTTTGTTTTRAT 660
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 2067 QIFRFTEEGMVNARFDYNYDNSFRVTSmQAVINETPLPIDLYRYDDVSGKTEQFGKFGVIYYDINQIITTAVMTHTKHFD 2146
Cdd:COG3209 661 GTTGTGTGVTAGLTTLATGGTTVGGGT-GTTSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGG 739
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 2147 AYGRMKEVQYEIFRSLMYWmTVQYDNMGRVVKKELKVGPYANTTRYSYEYDADGQLQTVSINDKPLWRYSYDLNGNLHLL 2226
Cdd:COG3209 740 TTGTLTTTSTTTTTTAGAL-TYTYDALGRLTSETTPGGVTQGTYTTRYTYDALGRLTSVTYPDGETVTYTYDALGRLTSV 818
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 2227 SPGNSARLTPL-----RYDIRDRITRLGDVQykmdEDGFLRQRggdiFEYNSAGLLIKAynRAGSWSVRYRYDGLGRRVS 2301
Cdd:COG3209 819 ITVGSGGGTDLqdrtyTYDAAGNITSITDAL----RAGTLTQT----YTYDALGRLTSA--TDPGTTESYTYDANGNLTS 888
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 2302 SKSSHSHHLQFFYADLtnPTKVTHlynhSSSEITSLYYDLQGHlfamelssgdefyiaCDNIGTPLAVFSGTGLMIKQIL 2381
Cdd:COG3209 889 RTDGGTTTYTYDALGR--LVSVTK----PDGTTTTYTYDALGH---------------TDHLGSVRALTDASGQVVWRYD 947
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 2382 YTAYGEIYMDTNPNFQIIIGYHGGLYDPLTKLVHMGRRDYDVLAGRWTSPDhelwkhlSSSNVMPFNLYMFKNNNPISNS 2461
Cdd:COG3209 948 YDPFGNLLAETSGAAANPLRFTGQEYDAETGLYYNGARYYDPALGRFLSPD-------PIGLAGGLNLYAYVGNNPVNYV 1020
|
|
| acid_disulf_rpt |
NF033662 |
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ... |
833-863 |
2.17e-09 |
|
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.
:
Pssm-ID: 411265 [Multi-domain] Cd Length: 32 Bit Score: 54.83 E-value: 2.17e-09
10 20 30
....*....|....*....|....*....|.
gi 169790825 833 SMETACGDSKDNDGDGLVDCMDPDCCLQPLC 863
Cdd:NF033662 2 ATDTTCSDGIDNDGDGLTDCADPDCAGNPVC 32
|
|
| DUF5885 super family |
cl44670 |
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown ... |
564-722 |
1.14e-05 |
|
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown function found in viruses.
The actual alignment was detected with superfamily member pfam19232:
Pssm-ID: 437064 Cd Length: 265 Bit Score: 49.62 E-value: 1.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 564 DNCPSNCYGNGDCISGTCH-----------------CFLGFLGPD---CGRASCpvlcsGNGQ----------YMKGRCL 613
Cdd:pfam19232 10 DDCTPPCGGTQVCIDRQCKdntlacttdaqcgtcmtCVAGACTPKascCGGVTC-----GAGQtcdaktntcvYVKGYCS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 614 C-HSGWKGAECDVPTNQCI---------DVAC--------------SNHGT----CITGTCI-----CNPGYKGESC--E 658
Cdd:pfam19232 85 AdHPCPSGSACDTAKNACIaqppygpdsGKGCvrgfgawiweldpaTNSGVwrcrCANGSLYnsaheCSPLADQTLCaaE 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 659 EVD-----------------------CMDPTCSGRGVC--VRGECHCSVGWGGTNCETPRAtcldqCSGHGTFLPDTGLC 713
Cdd:pfam19232 165 NLDpnalvpassvpafaaygwgnqpvLINKSTAGAAVPspLAGVCPCKPGWAGGSCTEDRT-----CNGRGTWNETTGQC 239
|
....*....
gi 169790825 714 SCDPSWTGH 722
Cdd:pfam19232 240 ACNIDFSGH 248
|
|
| DSL super family |
cl19567 |
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ... |
746-789 |
5.36e-05 |
|
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.
The actual alignment was detected with superfamily member pfam01414:
Pssm-ID: 473190 Cd Length: 46 Bit Score: 42.61 E-value: 5.36e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 169790825 746 CEDGWMGAACDqRACHPRCAE--HGTC-RDGKCECSPGWNGEHCTIA 789
Cdd:pfam01414 1 CDENYYGSTCS-KFCRPRDDKfgHYTCdANGNKVCLPGWTGPYCDKP 46
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Ten_N |
pfam06484 |
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of ... |
11-340 |
1.63e-157 |
|
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of the Teneurin family of proteins. These proteins are 'pair-rule' genes and are involved in tissue patterning, specifically probably neural patterning. The intracellular domain is cleaved in response to homophilic interaction of the extracellular domain, and translocates to the nucleus. Here it probably carries out to some transcriptional regulatory activity. The length of this region and the conservation suggests that there may be two structural domains here (personal obs:C Yeats).
Pssm-ID: 461932 [Multi-domain] Cd Length: 367 Bit Score: 492.57 E-value: 1.63e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 11 SLT-RRRDAERRYTSSSADSEEGKAP-QKSYSSSETLKAYDQDARLAYGSRVKDIVPQEAEEFCRTGANFTLRELGLEEV 88
Cdd:pfam06484 1 SLTkRRRDKERRYTSSSADSEECRVPtQKSYSSSETLKAFDHDSRMLYGNRVKDMVHKEADEFSRQGQNFSLRELGICEP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 89 TPPHGTLYRTDIGLPHCGYSMGAGSDADMEADTVLSPEHPVRLWGRSTRSGRSSCLSSRANSNLTLTDTEHENTETDHPG 168
Cdd:pfam06484 81 SPRHGLAYCTEMGLPHRGYSISTGSDADTETDGPMSPEHAVRLWGRGTKSGRSSCLSSRSNSALTLTDTEHENKSDNENG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 169 ----------------------------------------------------------------------GLQNHARLRT 178
Cdd:pfam06484 161 ppippsssssspveqhsppppslnenqrpllgnnashpildsdpdeefspnsylvrtgsgpqsapseqppNFQNHSRLRT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 179 PPPPLSHAHTPNQHHAASINSLNRGNFTPRSNPSPAPTdHSLSGEPPAggAQEPAHAQENWLLNSNIPLETRnlgkqpfl 258
Cdd:pfam06484 241 PPPPLPPPHKQNQHHHPSINSLNRSSLTNRRNPSPAPT-ASLPAELQS--TQESVQLQDSWVLNSNVPLETR-------- 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 259 gtlqdnliemdilgasrhdgaysdgHFLFKPG-GTSPLFCTTSPGYPLTSSTVYSPPPRPLPRSTFARPAFNLKKPSKYC 337
Cdd:pfam06484 310 -------------------------HFLFKTGtGTTPLFCTASPGYPLTSGTVYSPPPRPLPRNTFSRPAFKLKKPYKYC 364
|
...
gi 169790825 338 NWK 340
Cdd:pfam06484 365 SWK 367
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1222-1563 |
4.06e-46 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 170.02 E-value: 4.06e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1222 GLADGNKLLA----PVALTCGSDGSLYVGDF--NYIRRIFPSGNVTNILELRNKDFRHSHSPAHKYY----LATDPmSGA 1291
Cdd:cd14953 11 GFSGGGGTAArfnsPSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAGTGTAGFADGGGAAAQFNtpsgVAVDA-AGN 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1292 VFLSDSNSRRVFKIKSTVVVKdlvknseVVAGTGDQclpfddtRCGDGGKATEATLTNPRGITVDKFGLIYFVDGT--MI 1369
Cdd:cd14953 90 LYVADTGNHRIRKITPDGVVS-------TLAGTGTA-------GFSDDGGATAAQFNYPTGVAVDAAGNLYVADTGnhRI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1370 RRIDQNGIISTLLGsndlTSARPLSCDSVMdiSQVHLEWPTDLAINPMDNsLYVLD--NNVVLQISENHQVRIVAGRpmh 1447
Cdd:cd14953 156 RKITPDGVVTTVAG----TGGAGYAGDGPA--TAAQFNNPTGVAVDAAGN-LYVADrgNHRIRKITPDGVVTTVAGT--- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1448 cqvpGIDHFLLSKVAIHATLESATALAVSHNGVLYIAETDEkkiNRIRQVTTSGEISLVAGAPSGcdckndancdcFSGD 1527
Cdd:cd14953 226 ----GTAGFSGDGGATAAQLNNPTGVAVDAAGNLYVADSGN---HRIRKITPAGVVTTVAGGGAG-----------FSGD 287
|
330 340 350
....*....|....*....|....*....|....*.
gi 169790825 1528 DGYAKDAKLNTPSSLAVCADGELYVADLGNIRIRFI 1563
Cdd:cd14953 288 GGPATSAQFNNPTGVAVDAAGNLYVADTGNNRIRKI 323
|
|
| Tox-GHH |
pfam15636 |
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ... |
2685-2762 |
3.23e-38 |
|
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.
Pssm-ID: 464783 Cd Length: 78 Bit Score: 138.13 E-value: 3.23e-38
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 169790825 2685 EEKARVLELARQRAVRQAWAREQQRLREGEEGLRAWTEGEKQQVLSTGRVQGYDGFFVISVEQYPELSDSANNIHFMR 2762
Cdd:pfam15636 1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
1587-2461 |
1.02e-33 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 142.97 E-value: 1.02e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1587 YLFDTTGKHLYTQSLPTGDYLYNFTYTGDGDITLITDNNGNMVNVRRDSTGMPLWLVVPDGQVYWVTMGTNSALKSVTTQ 1666
Cdd:COG3209 185 GTGAVTLATGLAGSALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAATVTGSATGAAGAGAAVATAATTLGGTTG 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1667 GHELAMMTYHGNSGLLATKSNENgWTTFYEYDSFGRLTNVTFPTGQVSSFRSDTDSSVHVQVETSSKDDVTITTNLSASG 1746
Cdd:COG3209 265 AGTGASGAGLDASTGTGGAGGSN-AAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAVSGAADAGTTTTTGTGTG 343
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1747 AFYTLLQDQVRNSYYIGADGSLRLLLANGMEVALQTEPHLLAGTVNPTVGKRNVTLPIDNGLNLVEWRQRKEQARGQVTV 1826
Cdd:COG3209 344 GTTTTVGGGGSLTLGGYGAAGGLTTSVGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAA 423
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1827 FGRRLRVHNRNLLSLDFDRVTRTEKIYDDHRKFTLRILYDQAGRPSLWSPSSRLNGVNVTYSPGGYIAGIQRGIMSERME 1906
Cdd:COG3209 424 GALTAGGTATGTGTGGGGTTAGTDATTTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLD 503
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1907 YDQAGRITSRIFADGKTWSYTYLEksmVLLLHSQRQYIFEFDKNDRLSSVTMPNVARQTLETIRSVGYYRNIYQPPEGNA 1986
Cdd:COG3209 504 DTLGGTTTTTAGARGLVVTTGTTL---TLGTTTTATLSATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGAST 580
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1987 SVIQDFTEDGHLLHTFYLGTGRRVIYKYGKLSKLAETLYDTTKVSFTYDETAGMLKTINLQNEGFTCTIRYRQIGPLIDR 2066
Cdd:COG3209 581 TTGTTGGTATTTTVTTTTTTSTAGTTTTTTSGYTRAGLTLTLGTGTASGLERATASTGSTTGGTTGTGVTTTGTTTTRAT 660
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 2067 QIFRFTEEGMVNARFDYNYDNSFRVTSmQAVINETPLPIDLYRYDDVSGKTEQFGKFGVIYYDINQIITTAVMTHTKHFD 2146
Cdd:COG3209 661 GTTGTGTGVTAGLTTLATGGTTVGGGT-GTTSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGG 739
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 2147 AYGRMKEVQYEIFRSLMYWmTVQYDNMGRVVKKELKVGPYANTTRYSYEYDADGQLQTVSINDKPLWRYSYDLNGNLHLL 2226
Cdd:COG3209 740 TTGTLTTTSTTTTTTAGAL-TYTYDALGRLTSETTPGGVTQGTYTTRYTYDALGRLTSVTYPDGETVTYTYDALGRLTSV 818
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 2227 SPGNSARLTPL-----RYDIRDRITRLGDVQykmdEDGFLRQRggdiFEYNSAGLLIKAynRAGSWSVRYRYDGLGRRVS 2301
Cdd:COG3209 819 ITVGSGGGTDLqdrtyTYDAAGNITSITDAL----RAGTLTQT----YTYDALGRLTSA--TDPGTTESYTYDANGNLTS 888
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 2302 SKSSHSHHLQFFYADLtnPTKVTHlynhSSSEITSLYYDLQGHlfamelssgdefyiaCDNIGTPLAVFSGTGLMIKQIL 2381
Cdd:COG3209 889 RTDGGTTTYTYDALGR--LVSVTK----PDGTTTTYTYDALGH---------------TDHLGSVRALTDASGQVVWRYD 947
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 2382 YTAYGEIYMDTNPNFQIIIGYHGGLYDPLTKLVHMGRRDYDVLAGRWTSPDhelwkhlSSSNVMPFNLYMFKNNNPISNS 2461
Cdd:COG3209 948 YDPFGNLLAETSGAAANPLRFTGQEYDAETGLYYNGARYYDPALGRFLSPD-------PIGLAGGLNLYAYVGNNPVNYV 1020
|
|
| Rhs_assc_core |
TIGR03696 |
RHS repeat-associated core domain; This model represents a conserved unique core sequence ... |
2382-2461 |
4.94e-11 |
|
RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.
Pssm-ID: 274730 [Multi-domain] Cd Length: 77 Bit Score: 60.59 E-value: 4.94e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 2382 YTAYGEIyMDTNPNFQIIIGYHGGLYDPLTKLVHMGRRDYDVLAGRWTSPDhelwkhlsssnvmPF------NLYMFKNN 2455
Cdd:TIGR03696 1 YDPYGEV-LSESGAAPNPLRFTGQYYDAETGLYYNGARYYDPELGRFLSPD-------------PIglggglNLYAYVGN 66
|
....*.
gi 169790825 2456 NPISNS 2461
Cdd:TIGR03696 67 NPVNWV 72
|
|
| acid_disulf_rpt |
NF033662 |
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ... |
833-863 |
2.17e-09 |
|
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.
Pssm-ID: 411265 [Multi-domain] Cd Length: 32 Bit Score: 54.83 E-value: 2.17e-09
10 20 30
....*....|....*....|....*....|.
gi 169790825 833 SMETACGDSKDNDGDGLVDCMDPDCCLQPLC 863
Cdd:NF033662 2 ATDTTCSDGIDNDGDGLTDCADPDCAGNPVC 32
|
|
| PLN02919 |
PLN02919 |
haloacid dehalogenase-like hydrolase family protein |
1267-1561 |
5.41e-08 |
|
haloacid dehalogenase-like hydrolase family protein
Pssm-ID: 215497 [Multi-domain] Cd Length: 1057 Bit Score: 58.71 E-value: 5.41e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1267 RNKDFRHSHSPAhKY--YLATDPMSGAVFLSDSNSRRvfkikstVVVKDLVKNSEV-VAGTGDQCL---PFDDtrcgdgg 1340
Cdd:PLN02919 556 KDNDPRLLTSPL-KFpgKLAIDLLNNRLFISDSNHNR-------IVVTDLDGNFIVqIGSTGEEGLrdgSFED------- 620
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1341 kateATLTNPRGITVDKFGLIYFVDGT---MIRRID-QNGIISTLLGS----NDLTSARPLScdsvmdiSQVhLEWPTDL 1412
Cdd:PLN02919 621 ----ATFNRPQGLAYNAKKNLLYVADTenhALREIDfVNETVRTLAGNgtkgSDYQGGKKGT-------SQV-LNSPWDV 688
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1413 AINPMDNSLYVldnnvvlQISENHQV---RIVAGRPMHCQVPGIDHFLLSKVAIHATLESATALAVSHN-GVLYIAETDE 1488
Cdd:PLN02919 689 CFEPVNEKVYI-------AMAGQHQIweyNISDGVTRVFSGDGYERNLNGSSGTSTSFAQPSGISLSPDlKELYIADSES 761
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 169790825 1489 KKInRIRQVTTSGEISLVAGAPSGCDckndaNCDCFSGDDGYAKDAKLNTPSSLAVCADGELYVADLGNIRIR 1561
Cdd:PLN02919 762 SSI-RALDLKTGGSRLLAGGDPTFSD-----NLFKFGDHDGVGSEVLLQHPLGVLCAKDGQIYVADSYNHKIK 828
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1232-1507 |
1.39e-07 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 55.41 E-value: 1.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1232 PVALTCGSDGSLYVGDF--NYIRRIFP-SGNVTnilELRNKDFRHSHSpahkyyLATDPmSGAVFLSDSNSRRVFKI--K 1306
Cdd:COG4257 19 PRDVAVDPDGAVWFTDQggGRIGRLDPaTGEFT---EYPLGGGSGPHG------IAVDP-DGNLWFTDNGNNRIGRIdpK 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1307 STVVvkdlvknsEVVAGTGDQCLPFDDTRCGDG-------------------GKATEATL----TNPRGITVDKFGLIYF 1363
Cdd:COG4257 89 TGEI--------TTFALPGGGSNPHGIAFDPDGnlwftdqggnrigrldpatGEVTEFPLptggAGPYGIAVDPDGNLWV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1364 VD--GTMIRRID-QNGIISTLLGSNDLTSarplscdsvmdisqvhlewPTDLAINPmDNSLYVLDnnvvlqiSENHQVRI 1440
Cdd:COG4257 161 TDfgANAIGRIDpDTGTLTEYALPTPGAG-------------------PRGLAVDP-DGNLWVAD-------TGSGRIGR 213
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 169790825 1441 VAgrpmhcqvPGIDHFllSKVAIHATLESATALAVSHNGVLYIAETDekkINRIRQVTTSGEISLVA 1507
Cdd:COG4257 214 FD--------PKTGTV--TEYPLPGGGARPYGVAVDGDGRVWFAESG---ANRIVRFDPDTELTEYV 267
|
|
| DUF5885 |
pfam19232 |
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown ... |
564-722 |
1.14e-05 |
|
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown function found in viruses.
Pssm-ID: 437064 Cd Length: 265 Bit Score: 49.62 E-value: 1.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 564 DNCPSNCYGNGDCISGTCH-----------------CFLGFLGPD---CGRASCpvlcsGNGQ----------YMKGRCL 613
Cdd:pfam19232 10 DDCTPPCGGTQVCIDRQCKdntlacttdaqcgtcmtCVAGACTPKascCGGVTC-----GAGQtcdaktntcvYVKGYCS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 614 C-HSGWKGAECDVPTNQCI---------DVAC--------------SNHGT----CITGTCI-----CNPGYKGESC--E 658
Cdd:pfam19232 85 AdHPCPSGSACDTAKNACIaqppygpdsGKGCvrgfgawiweldpaTNSGVwrcrCANGSLYnsaheCSPLADQTLCaaE 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 659 EVD-----------------------CMDPTCSGRGVC--VRGECHCSVGWGGTNCETPRAtcldqCSGHGTFLPDTGLC 713
Cdd:pfam19232 165 NLDpnalvpassvpafaaygwgnqpvLINKSTAGAAVPspLAGVCPCKPGWAGGSCTEDRT-----CNGRGTWNETTGQC 239
|
....*....
gi 169790825 714 SCDPSWTGH 722
Cdd:pfam19232 240 ACNIDFSGH 248
|
|
| DSL |
pfam01414 |
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ... |
746-789 |
5.36e-05 |
|
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.
Pssm-ID: 460202 Cd Length: 46 Bit Score: 42.61 E-value: 5.36e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 169790825 746 CEDGWMGAACDqRACHPRCAE--HGTC-RDGKCECSPGWNGEHCTIA 789
Cdd:pfam01414 1 CDENYYGSTCS-KFCRPRDDKfgHYTCdANGNKVCLPGWTGPYCDKP 46
|
|
| RHS_repeat |
pfam05593 |
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ... |
1680-1712 |
6.22e-04 |
|
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.
Pssm-ID: 461685 [Multi-domain] Cd Length: 37 Bit Score: 39.50 E-value: 6.22e-04
10 20 30
....*....|....*....|....*....|...
gi 169790825 1680 GLLATKSNENGWTTFYEYDSFGRLTNVTFPTGQ 1712
Cdd:pfam05593 5 GRLTSVTDPDGRVTTYTYDAAGRLTAVTDPDGT 37
|
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
635-658 |
2.71e-03 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 37.62 E-value: 2.71e-03
10 20
....*....|....*....|....*...
gi 169790825 635 CSNHGTCITG----TCICNPGYKGESCE 658
Cdd:cd00054 11 CQNGGTCVNTvgsyRCSCPPGYTGRNCE 38
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Ten_N |
pfam06484 |
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of ... |
11-340 |
1.63e-157 |
|
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of the Teneurin family of proteins. These proteins are 'pair-rule' genes and are involved in tissue patterning, specifically probably neural patterning. The intracellular domain is cleaved in response to homophilic interaction of the extracellular domain, and translocates to the nucleus. Here it probably carries out to some transcriptional regulatory activity. The length of this region and the conservation suggests that there may be two structural domains here (personal obs:C Yeats).
Pssm-ID: 461932 [Multi-domain] Cd Length: 367 Bit Score: 492.57 E-value: 1.63e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 11 SLT-RRRDAERRYTSSSADSEEGKAP-QKSYSSSETLKAYDQDARLAYGSRVKDIVPQEAEEFCRTGANFTLRELGLEEV 88
Cdd:pfam06484 1 SLTkRRRDKERRYTSSSADSEECRVPtQKSYSSSETLKAFDHDSRMLYGNRVKDMVHKEADEFSRQGQNFSLRELGICEP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 89 TPPHGTLYRTDIGLPHCGYSMGAGSDADMEADTVLSPEHPVRLWGRSTRSGRSSCLSSRANSNLTLTDTEHENTETDHPG 168
Cdd:pfam06484 81 SPRHGLAYCTEMGLPHRGYSISTGSDADTETDGPMSPEHAVRLWGRGTKSGRSSCLSSRSNSALTLTDTEHENKSDNENG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 169 ----------------------------------------------------------------------GLQNHARLRT 178
Cdd:pfam06484 161 ppippsssssspveqhsppppslnenqrpllgnnashpildsdpdeefspnsylvrtgsgpqsapseqppNFQNHSRLRT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 179 PPPPLSHAHTPNQHHAASINSLNRGNFTPRSNPSPAPTdHSLSGEPPAggAQEPAHAQENWLLNSNIPLETRnlgkqpfl 258
Cdd:pfam06484 241 PPPPLPPPHKQNQHHHPSINSLNRSSLTNRRNPSPAPT-ASLPAELQS--TQESVQLQDSWVLNSNVPLETR-------- 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 259 gtlqdnliemdilgasrhdgaysdgHFLFKPG-GTSPLFCTTSPGYPLTSSTVYSPPPRPLPRSTFARPAFNLKKPSKYC 337
Cdd:pfam06484 310 -------------------------HFLFKTGtGTTPLFCTASPGYPLTSGTVYSPPPRPLPRNTFSRPAFKLKKPYKYC 364
|
...
gi 169790825 338 NWK 340
Cdd:pfam06484 365 SWK 367
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1222-1563 |
4.06e-46 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 170.02 E-value: 4.06e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1222 GLADGNKLLA----PVALTCGSDGSLYVGDF--NYIRRIFPSGNVTNILELRNKDFRHSHSPAHKYY----LATDPmSGA 1291
Cdd:cd14953 11 GFSGGGGTAArfnsPSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAGTGTAGFADGGGAAAQFNtpsgVAVDA-AGN 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1292 VFLSDSNSRRVFKIKSTVVVKdlvknseVVAGTGDQclpfddtRCGDGGKATEATLTNPRGITVDKFGLIYFVDGT--MI 1369
Cdd:cd14953 90 LYVADTGNHRIRKITPDGVVS-------TLAGTGTA-------GFSDDGGATAAQFNYPTGVAVDAAGNLYVADTGnhRI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1370 RRIDQNGIISTLLGsndlTSARPLSCDSVMdiSQVHLEWPTDLAINPMDNsLYVLD--NNVVLQISENHQVRIVAGRpmh 1447
Cdd:cd14953 156 RKITPDGVVTTVAG----TGGAGYAGDGPA--TAAQFNNPTGVAVDAAGN-LYVADrgNHRIRKITPDGVVTTVAGT--- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1448 cqvpGIDHFLLSKVAIHATLESATALAVSHNGVLYIAETDEkkiNRIRQVTTSGEISLVAGAPSGcdckndancdcFSGD 1527
Cdd:cd14953 226 ----GTAGFSGDGGATAAQLNNPTGVAVDAAGNLYVADSGN---HRIRKITPAGVVTTVAGGGAG-----------FSGD 287
|
330 340 350
....*....|....*....|....*....|....*.
gi 169790825 1528 DGYAKDAKLNTPSSLAVCADGELYVADLGNIRIRFI 1563
Cdd:cd14953 288 GGPATSAQFNNPTGVAVDAAGNLYVADTGNNRIRKI 323
|
|
| Tox-GHH |
pfam15636 |
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ... |
2685-2762 |
3.23e-38 |
|
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.
Pssm-ID: 464783 Cd Length: 78 Bit Score: 138.13 E-value: 3.23e-38
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 169790825 2685 EEKARVLELARQRAVRQAWAREQQRLREGEEGLRAWTEGEKQQVLSTGRVQGYDGFFVISVEQYPELSDSANNIHFMR 2762
Cdd:pfam15636 1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
1587-2461 |
1.02e-33 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 142.97 E-value: 1.02e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1587 YLFDTTGKHLYTQSLPTGDYLYNFTYTGDGDITLITDNNGNMVNVRRDSTGMPLWLVVPDGQVYWVTMGTNSALKSVTTQ 1666
Cdd:COG3209 185 GTGAVTLATGLAGSALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAATVTGSATGAAGAGAAVATAATTLGGTTG 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1667 GHELAMMTYHGNSGLLATKSNENgWTTFYEYDSFGRLTNVTFPTGQVSSFRSDTDSSVHVQVETSSKDDVTITTNLSASG 1746
Cdd:COG3209 265 AGTGASGAGLDASTGTGGAGGSN-AAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAVSGAADAGTTTTTGTGTG 343
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1747 AFYTLLQDQVRNSYYIGADGSLRLLLANGMEVALQTEPHLLAGTVNPTVGKRNVTLPIDNGLNLVEWRQRKEQARGQVTV 1826
Cdd:COG3209 344 GTTTTVGGGGSLTLGGYGAAGGLTTSVGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAA 423
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1827 FGRRLRVHNRNLLSLDFDRVTRTEKIYDDHRKFTLRILYDQAGRPSLWSPSSRLNGVNVTYSPGGYIAGIQRGIMSERME 1906
Cdd:COG3209 424 GALTAGGTATGTGTGGGGTTAGTDATTTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLD 503
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1907 YDQAGRITSRIFADGKTWSYTYLEksmVLLLHSQRQYIFEFDKNDRLSSVTMPNVARQTLETIRSVGYYRNIYQPPEGNA 1986
Cdd:COG3209 504 DTLGGTTTTTAGARGLVVTTGTTL---TLGTTTTATLSATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGAST 580
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1987 SVIQDFTEDGHLLHTFYLGTGRRVIYKYGKLSKLAETLYDTTKVSFTYDETAGMLKTINLQNEGFTCTIRYRQIGPLIDR 2066
Cdd:COG3209 581 TTGTTGGTATTTTVTTTTTTSTAGTTTTTTSGYTRAGLTLTLGTGTASGLERATASTGSTTGGTTGTGVTTTGTTTTRAT 660
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 2067 QIFRFTEEGMVNARFDYNYDNSFRVTSmQAVINETPLPIDLYRYDDVSGKTEQFGKFGVIYYDINQIITTAVMTHTKHFD 2146
Cdd:COG3209 661 GTTGTGTGVTAGLTTLATGGTTVGGGT-GTTSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGG 739
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 2147 AYGRMKEVQYEIFRSLMYWmTVQYDNMGRVVKKELKVGPYANTTRYSYEYDADGQLQTVSINDKPLWRYSYDLNGNLHLL 2226
Cdd:COG3209 740 TTGTLTTTSTTTTTTAGAL-TYTYDALGRLTSETTPGGVTQGTYTTRYTYDALGRLTSVTYPDGETVTYTYDALGRLTSV 818
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 2227 SPGNSARLTPL-----RYDIRDRITRLGDVQykmdEDGFLRQRggdiFEYNSAGLLIKAynRAGSWSVRYRYDGLGRRVS 2301
Cdd:COG3209 819 ITVGSGGGTDLqdrtyTYDAAGNITSITDAL----RAGTLTQT----YTYDALGRLTSA--TDPGTTESYTYDANGNLTS 888
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 2302 SKSSHSHHLQFFYADLtnPTKVTHlynhSSSEITSLYYDLQGHlfamelssgdefyiaCDNIGTPLAVFSGTGLMIKQIL 2381
Cdd:COG3209 889 RTDGGTTTYTYDALGR--LVSVTK----PDGTTTTYTYDALGH---------------TDHLGSVRALTDASGQVVWRYD 947
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 2382 YTAYGEIYMDTNPNFQIIIGYHGGLYDPLTKLVHMGRRDYDVLAGRWTSPDhelwkhlSSSNVMPFNLYMFKNNNPISNS 2461
Cdd:COG3209 948 YDPFGNLLAETSGAAANPLRFTGQEYDAETGLYYNGARYYDPALGRFLSPD-------PIGLAGGLNLYAYVGNNPVNYV 1020
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1227-1563 |
4.46e-19 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 89.69 E-value: 4.46e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1227 NKLLAPVALTCGSDGSLYVGDF--NYIRRIFPSGNVTNILELRNKDFRHSHSPAHkyyLATDPmSGAVFLSDSNSRRVFK 1304
Cdd:cd05819 5 GELNNPQGIAVDSSGNIYVADTgnNRIQVFDPDGNFITSFGSFGSGDGQFNEPAG---VAVDS-DGNLYVADTGNHRIQK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1305 IKStvvvkdlvkNSEVVAGTGdqclpfddtrcGDGGKATEatLTNPRGITVDKFGLIYFVDgTM---IRRIDQNGIISTL 1381
Cdd:cd05819 81 FDP---------DGNFLASFG-----------GSGDGDGE--FNGPRGIAVDSSGNIYVAD-TGnhrIQKFDPDGEFLTT 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1382 LGSNDLTSArplscdsvmdisqvHLEWPTDLAINPmDNSLYVLDnnvvlqiSENHQVRIVAgrpmhcqvPGiDHFLL--- 1458
Cdd:cd05819 138 FGSGGSGPG--------------QFNGPTGVAVDS-DGNIYVAD-------TGNHRIQVFD--------PD-GNFLTtfg 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1459 SKVAIHATLESATALAVSHNGVLYIAETDEkkiNRIRQVTTSGEISLVAGAPSGcdckndancdcfsgddgyaKDAKLNT 1538
Cdd:cd05819 187 STGTGPGQFNYPTGIAVDSDGNIYVADSGN---NRVQVFDPDGAGFGGNGNFLG-------------------SDGQFNR 244
|
330 340
....*....|....*....|....*
gi 169790825 1539 PSSLAVCADGELYVADLGNIRIRFI 1563
Cdd:cd05819 245 PSGLAVDSDGNLYVADTGNNRIQVF 269
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1347-1631 |
5.47e-18 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 86.60 E-value: 5.47e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1347 LTNPRGITVDKFGLIYFVDGTM--IRRIDQNGIISTLLGSNDLTSARplscdsvmdisqvhLEWPTDLAINPmDNSLYVL 1424
Cdd:cd05819 7 LNNPQGIAVDSSGNIYVADTGNnrIQVFDPDGNFITSFGSFGSGDGQ--------------FNEPAGVAVDS-DGNLYVA 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1425 D--NNVVLQISENHQVRIVAGRPmhcqvpGIDHFLLSkvaihatleSATALAVSHNGVLYIAETDEkkiNRIRQVTTSGE 1502
Cdd:cd05819 72 DtgNHRIQKFDPDGNFLASFGGS------GDGDGEFN---------GPRGIAVDSSGNIYVADTGN---HRIQKFDPDGE 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1503 ISLVAGAPSGCDckndancdcfsgddgyakdAKLNTPSSLAVCADGELYVADLGNIRIRFIrknkpflntqnmyelsSPI 1582
Cdd:cd05819 134 FLTTFGSGGSGP-------------------GQFNGPTGVAVDSDGNIYVADTGNHRIQVF----------------DPD 178
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 169790825 1583 DQELYLFDTTGKHLYTQSLPTGDylynfTYTGDGDItLITDNNGNMVNV 1631
Cdd:cd05819 179 GNFLTTFGSTGTGPGQFNYPTGI-----AVDSDGNI-YVADSGNNRVQV 221
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1219-1372 |
2.94e-14 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 76.41 E-value: 2.94e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1219 SCNGLADGNKLLAPVALTCGSDGSLYVGDF--NYIRRIFPSGNVTNILELRNKDFRHS--------HSPahkYYLATDPm 1288
Cdd:cd14953 176 AGDGPATAAQFNNPTGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAGTGTAGFSGDggataaqlNNP---TGVAVDA- 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1289 SGAVFLSDSNSRRVFKIKSTVVVkdlvknSEVVAGTGDQclpfddtrCGDGGKATEATLTNPRGITVDKFGLIYFVD--G 1366
Cdd:cd14953 252 AGNLYVADSGNHRIRKITPAGVV------TTVAGGGAGF--------SGDGGPATSAQFNNPTGVAVDAAGNLYVADtgN 317
|
....*.
gi 169790825 1367 TMIRRI 1372
Cdd:cd14953 318 NRIRKI 323
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1225-1494 |
2.38e-13 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 72.74 E-value: 2.38e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1225 DGNKLLAPVALTCGSDGSLYVGDF--NYIRRIFPSGNVTN---ILELRNKDFRHshsPahkYYLATDPmSGAVFLSDSNS 1299
Cdd:cd05819 50 GDGQFNEPAGVAVDSDGNLYVADTgnHRIQKFDPDGNFLAsfgGSGDGDGEFNG---P---RGIAVDS-SGNIYVADTGN 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1300 RRVFKIKStvvvkdlvkNSEVVAGTGdqclpfddtrcgdGGKATEATLTNPRGITVDKFGLIYFVDGT--MIRRIDQNGI 1377
Cdd:cd05819 123 HRIQKFDP---------DGEFLTTFG-------------SGGSGPGQFNGPTGVAVDSDGNIYVADTGnhRIQVFDPDGN 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1378 ISTLLGSNDLTSARplscdsvmdisqvhLEWPTDLAINPMDNsLYVLD--NNVVLQISENHQVRIVAGrpmhcqvpgidh 1455
Cdd:cd05819 181 FLTTFGSTGTGPGQ--------------FNYPTGIAVDSDGN-IYVADsgNNRVQVFDPDGAGFGGNG------------ 233
|
250 260 270
....*....|....*....|....*....|....*....
gi 169790825 1456 fllSKVAIHATLESATALAVSHNGVLYIAETDEKKINRI 1494
Cdd:cd05819 234 ---NFLGSDGQFNRPSGLAVDSDGNLYVADTGNNRIQVF 269
|
|
| Rhs_assc_core |
TIGR03696 |
RHS repeat-associated core domain; This model represents a conserved unique core sequence ... |
2382-2461 |
4.94e-11 |
|
RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.
Pssm-ID: 274730 [Multi-domain] Cd Length: 77 Bit Score: 60.59 E-value: 4.94e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 2382 YTAYGEIyMDTNPNFQIIIGYHGGLYDPLTKLVHMGRRDYDVLAGRWTSPDhelwkhlsssnvmPF------NLYMFKNN 2455
Cdd:TIGR03696 1 YDPYGEV-LSESGAAPNPLRFTGQYYDAETGLYYNGARYYDPELGRFLSPD-------------PIglggglNLYAYVGN 66
|
....*.
gi 169790825 2456 NPISNS 2461
Cdd:TIGR03696 67 NPVNWV 72
|
|
| NHL_PKND_like |
cd14952 |
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ... |
1283-1560 |
9.66e-10 |
|
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 61.84 E-value: 9.66e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1283 LATDPmSGAVFLSDSNSRRVFKikstvvvkdlvknseVVAGTGDQC-LPFDDtrcgdggkateatLTNPRGITVDKFGLI 1361
Cdd:cd14952 15 VAVDA-AGNVYVADSGNNRVLK---------------LAAGSTTQTvLPFTG-------------LYQPQGVAVDAAGTV 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1362 YFVDGtmirriDQNGIISTLLGSNDLTsarPLSCDSvmdisqvhLEWPTDLAINPMDNsLYVLD--NNVVLqisenhqvR 1439
Cdd:cd14952 66 YVTDF------GNNRVLKLAAGSTTQT---VLPFTG--------LNDPTGVAVDAAGN-VYVADtgNNRVL--------K 119
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1440 IVAGRPMHCQVPgidhFllskvaihATLESATALAVSHNGVLYIAETDEkkiNRIRQvttsgeisLVAGA------Psgc 1513
Cdd:cd14952 120 LAAGSNTQTVLP----F--------TGLSNPDGVAVDGAGNVYVTDTGN---NRVLK--------LAAGSttqtvlP--- 173
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 169790825 1514 dckndancdcFSGddgyakdakLNTPSSLAVCADGELYVADLGNIRI 1560
Cdd:cd14952 174 ----------FTG---------LNSPSGVAVDTAGNVYVTDHGNNRV 201
|
|
| acid_disulf_rpt |
NF033662 |
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ... |
833-863 |
2.17e-09 |
|
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.
Pssm-ID: 411265 [Multi-domain] Cd Length: 32 Bit Score: 54.83 E-value: 2.17e-09
10 20 30
....*....|....*....|....*....|.
gi 169790825 833 SMETACGDSKDNDGDGLVDCMDPDCCLQPLC 863
Cdd:NF033662 2 ATDTTCSDGIDNDGDGLTDCADPDCAGNPVC 32
|
|
| PLN02919 |
PLN02919 |
haloacid dehalogenase-like hydrolase family protein |
1267-1561 |
5.41e-08 |
|
haloacid dehalogenase-like hydrolase family protein
Pssm-ID: 215497 [Multi-domain] Cd Length: 1057 Bit Score: 58.71 E-value: 5.41e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1267 RNKDFRHSHSPAhKY--YLATDPMSGAVFLSDSNSRRvfkikstVVVKDLVKNSEV-VAGTGDQCL---PFDDtrcgdgg 1340
Cdd:PLN02919 556 KDNDPRLLTSPL-KFpgKLAIDLLNNRLFISDSNHNR-------IVVTDLDGNFIVqIGSTGEEGLrdgSFED------- 620
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1341 kateATLTNPRGITVDKFGLIYFVDGT---MIRRID-QNGIISTLLGS----NDLTSARPLScdsvmdiSQVhLEWPTDL 1412
Cdd:PLN02919 621 ----ATFNRPQGLAYNAKKNLLYVADTenhALREIDfVNETVRTLAGNgtkgSDYQGGKKGT-------SQV-LNSPWDV 688
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1413 AINPMDNSLYVldnnvvlQISENHQV---RIVAGRPMHCQVPGIDHFLLSKVAIHATLESATALAVSHN-GVLYIAETDE 1488
Cdd:PLN02919 689 CFEPVNEKVYI-------AMAGQHQIweyNISDGVTRVFSGDGYERNLNGSSGTSTSFAQPSGISLSPDlKELYIADSES 761
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 169790825 1489 KKInRIRQVTTSGEISLVAGAPSGCDckndaNCDCFSGDDGYAKDAKLNTPSSLAVCADGELYVADLGNIRIR 1561
Cdd:PLN02919 762 SSI-RALDLKTGGSRLLAGGDPTFSD-----NLFKFGDHDGVGSEVLLQHPLGVLCAKDGQIYVADSYNHKIK 828
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1232-1507 |
1.39e-07 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 55.41 E-value: 1.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1232 PVALTCGSDGSLYVGDF--NYIRRIFP-SGNVTnilELRNKDFRHSHSpahkyyLATDPmSGAVFLSDSNSRRVFKI--K 1306
Cdd:COG4257 19 PRDVAVDPDGAVWFTDQggGRIGRLDPaTGEFT---EYPLGGGSGPHG------IAVDP-DGNLWFTDNGNNRIGRIdpK 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1307 STVVvkdlvknsEVVAGTGDQCLPFDDTRCGDG-------------------GKATEATL----TNPRGITVDKFGLIYF 1363
Cdd:COG4257 89 TGEI--------TTFALPGGGSNPHGIAFDPDGnlwftdqggnrigrldpatGEVTEFPLptggAGPYGIAVDPDGNLWV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1364 VD--GTMIRRID-QNGIISTLLGSNDLTSarplscdsvmdisqvhlewPTDLAINPmDNSLYVLDnnvvlqiSENHQVRI 1440
Cdd:COG4257 161 TDfgANAIGRIDpDTGTLTEYALPTPGAG-------------------PRGLAVDP-DGNLWVAD-------TGSGRIGR 213
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 169790825 1441 VAgrpmhcqvPGIDHFllSKVAIHATLESATALAVSHNGVLYIAETDekkINRIRQVTTSGEISLVA 1507
Cdd:COG4257 214 FD--------PKTGTV--TEYPLPGGGARPYGVAVDGDGRVWFAESG---ANRIVRFDPDTELTEYV 267
|
|
| NHL_like_3 |
cd14956 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1349-1560 |
2.84e-07 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271326 [Multi-domain] Cd Length: 274 Bit Score: 54.60 E-value: 2.84e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1349 NPRGITVDKFGLIYFVD--GTMIRRIDQNGIISTLLGSndlTSARPlscdsvmdisqVHLEWPTDLAINPmDNSLYVLDn 1426
Cdd:cd14956 108 APRGVAVDADGNLYVADfgNQRIQKFDPDGSFLRQWGG---TGIEP-----------GSFNYPRGVAVDP-DGTLYVAD- 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1427 nvvlqiSENHQVrivagrpmhcQVPGIDHFLLSKVAIHAT----LESATALAVSHNGVLYIAETDEkkiNRIRQVTTSGE 1502
Cdd:cd14956 172 ------TYNDRI----------QVFDNDGAFLRKWGGRGTgpgqFNYPYGIAIDPDGNVFVADFGN---NRIQKFTADGT 232
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 169790825 1503 ISLVAGAPSGcdckndancdcfsgddgyaKDAKLNTPSSLAVCADGELYVADLGNIRI 1560
Cdd:cd14956 233 FLTSWGSPGT-------------------GPGQFKNPWGVVVDADGTVYVADSNNNRV 271
|
|
| DUF5885 |
pfam19232 |
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown ... |
564-722 |
1.14e-05 |
|
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown function found in viruses.
Pssm-ID: 437064 Cd Length: 265 Bit Score: 49.62 E-value: 1.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 564 DNCPSNCYGNGDCISGTCH-----------------CFLGFLGPD---CGRASCpvlcsGNGQ----------YMKGRCL 613
Cdd:pfam19232 10 DDCTPPCGGTQVCIDRQCKdntlacttdaqcgtcmtCVAGACTPKascCGGVTC-----GAGQtcdaktntcvYVKGYCS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 614 C-HSGWKGAECDVPTNQCI---------DVAC--------------SNHGT----CITGTCI-----CNPGYKGESC--E 658
Cdd:pfam19232 85 AdHPCPSGSACDTAKNACIaqppygpdsGKGCvrgfgawiweldpaTNSGVwrcrCANGSLYnsaheCSPLADQTLCaaE 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 659 EVD-----------------------CMDPTCSGRGVC--VRGECHCSVGWGGTNCETPRAtcldqCSGHGTFLPDTGLC 713
Cdd:pfam19232 165 NLDpnalvpassvpafaaygwgnqpvLINKSTAGAAVPspLAGVCPCKPGWAGGSCTEDRT-----CNGRGTWNETTGQC 239
|
....*....
gi 169790825 714 SCDPSWTGH 722
Cdd:pfam19232 240 ACNIDFSGH 248
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1281-1563 |
1.22e-05 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 49.63 E-value: 1.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1281 YYLATDPmSGAVFLSDSNSRRVFKIkstvvvkdlvknsevvagtgdqclpfdDTRCGDGGKATEATLTNPRGITVDKFGL 1360
Cdd:COG4257 20 RDVAVDP-DGAVWFTDQGGGRIGRL---------------------------DPATGEFTEYPLGGGSGPHGIAVDPDGN 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1361 IYFVDGT--MIRRID-QNGIISTLLGSNDLTSarplscdsvmdisqvhlewPTDLAINPmDNSLYVLD--NNVVLQIS-E 1434
Cdd:COG4257 72 LWFTDNGnnRIGRIDpKTGEITTFALPGGGSN-------------------PHGIAFDP-DGNLWFTDqgGNRIGRLDpA 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1435 NHQVRIVAgrpmhcqVPGIDHFllskvaihatlesATALAVSHNGVLYIAETdekKINRIRQVTT-SGEISLvagapsgc 1513
Cdd:COG4257 132 TGEVTEFP-------LPTGGAG-------------PYGIAVDPDGNLWVTDF---GANAIGRIDPdTGTLTE-------- 180
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 169790825 1514 dckndancdcfsgddgYAKDAKLNTPSSLAVCADGELYVADLGNIRIRFI 1563
Cdd:COG4257 181 ----------------YALPTPGAGPRGLAVDPDGNLWVADTGSGRIGRF 214
|
|
| NHL_like_2 |
cd14957 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
1350-1583 |
3.35e-05 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271327 [Multi-domain] Cd Length: 280 Bit Score: 48.42 E-value: 3.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1350 PRGITVDKFGLIYFVD--GTMIRRIDQNGIISTLLGSNDltsarplscdsvmdISQVHLEWPTDLAINPMDNsLYVLDnn 1427
Cdd:cd14957 20 PRGIAVDSAGNIYVADtgNNRIQVFTSSGVYSYSIGSGG--------------TGSGQFNSPYGIAVDSNGN-IYVAD-- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1428 vvlqiSENHQVRIvagrpmhcqvpgidhFLLSKVAIHA---------TLESATALAVSHNGVLYIAETDEkkiNRIrQVT 1498
Cdd:cd14957 83 -----TDNNRIQV---------------FNSSGVYQYSigtggsgdgQFNGPYGIAVDSNGNIYVADTGN---HRI-QVF 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1499 TSgeislvAGAPsgcdckndancdCFSGDDGYAKDAKLNTPSSLAVCADGELYVADLGNIRIRFIRKNKPFLNT-----Q 1573
Cdd:cd14957 139 TS------SGTF------------SYSIGSGGTGPGQFNGPQGIAVDSDGNIYVADTGNHRIQVFTSSGTFQYTfgssgS 200
|
250
....*....|
gi 169790825 1574 NMYELSSPID 1583
Cdd:cd14957 201 GPGQFSDPYG 210
|
|
| NHL_like_3 |
cd14956 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1339-1560 |
4.27e-05 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271326 [Multi-domain] Cd Length: 274 Bit Score: 48.05 E-value: 4.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1339 GGKATEA-TLTNPRGITVDKFGLIYFVDGT--MIRRIDQNGIISTLLGSNdltSARPLSCDSvmdisqvhlewPTDLAIN 1415
Cdd:cd14956 50 GTTGDGPgQFGRPRGLAVDKDGWLYVADYWgdRIQVFTLTGELQTIGGSS---GSGPGQFNA-----------PRGVAVD 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1416 PmDNSLYVLD--NNVVLQISENHQ-VRIVAGRPmhcQVPGidHFLlskvaihatleSATALAVSHNGVLYIAETdekKIN 1492
Cdd:cd14956 116 A-DGNLYVADfgNQRIQKFDPDGSfLRQWGGTG---IEPG--SFN-----------YPRGVAVDPDGTLYVADT---YND 175
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 169790825 1493 RIRQVTTSGEISLVAGAPSGcdckndancdcFSGDdgyakdakLNTPSSLAVCADGELYVADLGNIRI 1560
Cdd:cd14956 176 RIQVFDNDGAFLRKWGGRGT-----------GPGQ--------FNYPYGIAIDPDGNVFVADFGNNRI 224
|
|
| NHL_like_2 |
cd14957 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
1468-1627 |
5.23e-05 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271327 [Multi-domain] Cd Length: 280 Bit Score: 47.65 E-value: 5.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1468 ESATALAVSHNGVLYIAETDEkkiNRIRQVTTSGEISLVAGapsgcdckndancdcfSGDDGyakDAKLNTPSSLAVCAD 1547
Cdd:cd14957 65 NSPYGIAVDSNGNIYVADTDN---NRIQVFNSSGVYQYSIG----------------TGGSG---DGQFNGPYGIAVDSN 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1548 GELYVADLGNIRIRFIRKNKPFLNT-----QNMYELSSP----IDQE--LYLFDTTGK--HLYTqslPTGDYLYNFTYTG 1614
Cdd:cd14957 123 GNIYVADTGNHRIQVFTSSGTFSYSigsggTGPGQFNGPqgiaVDSDgnIYVADTGNHriQVFT---SSGTFQYTFGSSG 199
|
170
....*....|....*....
gi 169790825 1615 DGDITLIT------DNNGN 1627
Cdd:cd14957 200 SGPGQFSDpygiavDSDGN 218
|
|
| DSL |
pfam01414 |
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ... |
746-789 |
5.36e-05 |
|
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.
Pssm-ID: 460202 Cd Length: 46 Bit Score: 42.61 E-value: 5.36e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 169790825 746 CEDGWMGAACDqRACHPRCAE--HGTC-RDGKCECSPGWNGEHCTIA 789
Cdd:pfam01414 1 CDENYYGSTCS-KFCRPRDDKfgHYTCdANGNKVCLPGWTGPYCDKP 46
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1503-1563 |
7.31e-05 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 47.52 E-value: 7.31e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 169790825 1503 ISLVAGAPSGcdckndancdcfSGDDGYAKDAKLNTPSSLAVCADGELYVADLGNIRIRFI 1563
Cdd:cd14953 1 VSTVAGSGTA------------GFSGGGGTAARFNSPSGVAVDAAGNLYVADRGNHRIRKI 49
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
634-657 |
2.62e-04 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 40.41 E-value: 2.62e-04
10 20
....*....|....*....|....*.
gi 169790825 634 ACSNHGTCI--TGTCICNPGYKGESC 657
Cdd:pfam07974 1 ICSGRGTCVnqCGKCVCDSGYQGATC 26
|
|
| YD_repeat_2x |
TIGR01643 |
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular ... |
1676-1716 |
2.95e-04 |
|
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular repeat found in Gram-negative, Gram-positive, and animal proteins. The repeat is named for a YD dipeptide, the most strongly conserved motif of the repeat. These repeats appear in general to be involved in binding carbohydrate; the chicken teneurin-1 YD-repeat region has been shown to bind heparin.
Pssm-ID: 273728 [Multi-domain] Cd Length: 42 Bit Score: 40.27 E-value: 2.95e-04
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 169790825 1676 HGNSGLLATKSNENGWTTFYEYDSFGRLTNVTFPTGQVSSF 1716
Cdd:TIGR01643 1 YDAAGRLTGSTDADGTTTRYTYDAAGRLVEITDADGGSTRY 41
|
|
| NHL-2_like |
cd14951 |
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ... |
1283-1442 |
2.97e-04 |
|
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271321 [Multi-domain] Cd Length: 334 Bit Score: 45.65 E-value: 2.97e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1283 LATDPmSGAVFLSDSNSrrvfkikSTVVVKDLvKNSEVVAGTGDQCLP---FDdtrCGD-GGKATEATLTNPRGITVDKF 1358
Cdd:cd14951 139 LSLAG-WGELFVADSES-------SAIRAVSL-KDGGVKTLVGGTRVGtglFD---FGDrDGPGAEALLQHPLGVAALPD 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1359 GLIYFVDgTM---IRRID-QNGIISTLLGSNDLTSARPLSCDSVmdisqvhlewPTDLAINPmDNSLYVLDNNvvlqise 1434
Cdd:cd14951 207 GSVYVAD-TYnhkIKRVDpATGEVSTLAGTGKAGYKDLEAQFSE----------PSGLVVDG-DGRLYVADTN------- 267
|
....*...
gi 169790825 1435 NHQVRIVA 1442
Cdd:cd14951 268 NHRIRRLD 275
|
|
| NHL-2_like |
cd14951 |
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ... |
1474-1564 |
3.27e-04 |
|
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271321 [Multi-domain] Cd Length: 334 Bit Score: 45.65 E-value: 3.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1474 AVSHNGVLYIAETdekKINRIRQV-TTSGEISLVAGapsgcdckndancdcfSGDDGYA-KDAKLNTPSSLAVCADGELY 1551
Cdd:cd14951 202 AALPDGSVYVADT---YNHKIKRVdPATGEVSTLAG----------------TGKAGYKdLEAQFSEPSGLVVDGDGRLY 262
|
90
....*....|...
gi 169790825 1552 VADLGNIRIRFIR 1564
Cdd:cd14951 263 VADTNNHRIRRLD 275
|
|
| NHL_like_5 |
cd14963 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1228-1486 |
4.30e-04 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 44.97 E-value: 4.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1228 KLLAPVALTCGSDGSLYVGDFnYIRRI--F-PSGNVTNILElRNKDFRHSHSPAHkyyLATDpmSGAVFLSDSNsrrvfk 1304
Cdd:cd14963 54 EFKYPYGIAVDSDGNIYVADL-YNGRIqvFdPDGKFLKYFP-EKKDRVKLISPAG---LAID--DGKLYVSDVK------ 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1305 iKSTVVVKDLvknsevvagTGDQCLPFddtrcGDGGKAtEATLTNPRGITVDKFGLIYFVDgTMIRRI---DQNG-IIST 1380
Cdd:cd14963 121 -KHKVIVFDL---------EGKLLLEF-----GKPGSE-PGELSYPNGIAVDEDGNIYVAD-SGNGRIqvfDKNGkFIKE 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1381 LLGSNDLTSArplscdsvmdisqvhLEWPTDLAINPmDNSLYVLDN--NVVLQISENHQVRIVAGRpmhcqvPGIDhfll 1458
Cdd:cd14963 184 LNGSPDGKSG---------------FVNPRGIAVDP-DGNLYVVDNlsHRVYVFDEQGKELFTFGG------RGKD---- 237
|
250 260
....*....|....*....|....*...
gi 169790825 1459 skvaiHATLESATALAVSHNGVLYIAET 1486
Cdd:cd14963 238 -----DGQFNLPNGLFIDDDGRLYVTDR 260
|
|
| RHS_repeat |
pfam05593 |
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ... |
1680-1712 |
6.22e-04 |
|
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.
Pssm-ID: 461685 [Multi-domain] Cd Length: 37 Bit Score: 39.50 E-value: 6.22e-04
10 20 30
....*....|....*....|....*....|...
gi 169790825 1680 GLLATKSNENGWTTFYEYDSFGRLTNVTFPTGQ 1712
Cdd:pfam05593 5 GRLTSVTDPDGRVTTYTYDAAGRLTAVTDPDGT 37
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1227-1305 |
2.26e-03 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 42.70 E-value: 2.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790825 1227 NKLLAPVALTCGSDGSLYVGDF--NYIRRIFP-SGNVTNilelrnkdFRHSHSPAHKYYLATDPmSGAVFLSDSNSRRVF 1303
Cdd:COG4257 185 TPGAGPRGLAVDPDGNLWVADTgsGRIGRFDPkTGTVTE--------YPLPGGGARPYGVAVDG-DGRVWFAESGANRIV 255
|
..
gi 169790825 1304 KI 1305
Cdd:COG4257 256 RF 257
|
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
635-658 |
2.71e-03 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 37.62 E-value: 2.71e-03
10 20
....*....|....*....|....*...
gi 169790825 635 CSNHGTCITG----TCICNPGYKGESCE 658
Cdd:cd00054 11 CQNGGTCVNTvgsyRCSCPPGYTGRNCE 38
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
764-786 |
4.14e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 36.94 E-value: 4.14e-03
|
| EGF |
pfam00008 |
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ... |
635-655 |
5.61e-03 |
|
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.
Pssm-ID: 394967 Cd Length: 31 Bit Score: 36.59 E-value: 5.61e-03
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
700-724 |
6.83e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 36.17 E-value: 6.83e-03
|
| |
