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Conserved domains on  [gi|149999376|ref|NP_001092301|]
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MORN repeat-containing protein 4 [Homo sapiens]

Protein Classification

MORN repeat-containing protein( domain architecture ID 11468649)

membrane-occupation-and-recognition-nexus (MORN) repeat-containing protein may be involved in protein-protein interactions

PubMed:  33296386|35568981

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
5-118 1.55e-31

Uncharacterized conserved protein [Function unknown];


:

Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 113.13  E-value: 1.55e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149999376   5 KGSFTYSSGEEYRGEWKEGRRHGFGQLMFADGGTYLGHFENGLFNGFGVLTFSDGSRYEGEFAQGKFNGVGVFIRYDNMT 84
Cdd:COG4642  162 QGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDR 241

                         90       100       110
                 ....*....|....*....|....*....|....
gi 149999376  85 FEGEFKNGRVDGFGLLTFPDGShgipRNEGLFEN 118
Cdd:COG4642  242 YEGEFKNGKRHGQGTMTYADGS----VYEGEWKN 271
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
5-118 1.55e-31

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 113.13  E-value: 1.55e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149999376   5 KGSFTYSSGEEYRGEWKEGRRHGFGQLMFADGGTYLGHFENGLFNGFGVLTFSDGSRYEGEFAQGKFNGVGVFIRYDNMT 84
Cdd:COG4642  162 QGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDR 241

                         90       100       110
                 ....*....|....*....|....*....|....
gi 149999376  85 FEGEFKNGRVDGFGLLTFPDGShgipRNEGLFEN 118
Cdd:COG4642  242 YEGEFKNGKRHGQGTMTYADGS----VYEGEWKN 271
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 6-143 1.89e-15

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 71.79  E-value: 1.89e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149999376   6 GSFTYSSGEEYRGEWKEGRRHGFGQLMFADGGTYLGHFENGLFNGFGVLTFSDGSRYEGEFAQGKFNGVGVFIRYDNMTF 85
Cdd:PLN03185  93 GYQRYPNGDVFEGSWIQGLQEGPGKYTWANGNVYLGDMKGGKMSGKGTLTWVSGDSYEGQWLDGMMHGFGVYTWSDGGCY 172

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 149999376  86 EGEFKNGRVDGFGLLtFPDGSHgIPRNEGLFENNkLLRREKCSAIVQRAQSASKSARN 143
Cdd:PLN03185 173 VGTWTRGLKDGKGVF-YPAGSR-VPAVQEFYLNA-LRKRGVLPDLRRQNQVLSSHNSE 227
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
16-35 1.08e-03

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 34.62  E-value: 1.08e-03
                           10        20
                   ....*....|....*....|
gi 149999376    16 YRGEWKEGRRHGFGQLMFAD 35
Cdd:smart00698   3 YEGEWRNGKRHGRGVYTYAN 22
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 16-38 1.26e-03

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 34.31  E-value: 1.26e-03
                          10        20
                  ....*....|....*....|...
gi 149999376   16 YRGEWKEGRRHGFGQLMFADGGT 38
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
5-118 1.55e-31

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 113.13  E-value: 1.55e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149999376   5 KGSFTYSSGEEYRGEWKEGRRHGFGQLMFADGGTYLGHFENGLFNGFGVLTFSDGSRYEGEFAQGKFNGVGVFIRYDNMT 84
Cdd:COG4642  162 QGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDR 241

                         90       100       110
                 ....*....|....*....|....*....|....
gi 149999376  85 FEGEFKNGRVDGFGLLTFPDGShgipRNEGLFEN 118
Cdd:COG4642  242 YEGEFKNGKRHGQGTMTYADGS----VYEGEWKN 271
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
4-121 1.65e-28

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 105.42  E-value: 1.65e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149999376   4 TKGSFTYSSGEEYRGEWKEGRRHGFGQLMFADGGTYLGHFENGLFNGFGVLTFSDGSRYEGEFAQGKFNGVGVFIRYDNM 83
Cdd:COG4642  138 GGGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYADGD 217

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 149999376  84 TFEGEFKNGRVDGFGLLTFPDGShgipRNEGLFENNKL 121
Cdd:COG4642  218 RYEGEFKNGKRHGQGTLTYADGD----RYEGEFKNGKR 251
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
5-121 2.58e-25

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 96.95  E-value: 2.58e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149999376   5 KGSFTYSSGEEYRGEWKEGRRHGFGQLMFADGGTYLGHFENGLFNGFGVLTFSDGSRYEGEFAQGKFNGVGVFIRYDNMT 84
Cdd:COG4642  116 GGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDV 195

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 149999376  85 FEGEFKNGRVDGFGLLTFPDGShgipRNEGLFENNKL 121
Cdd:COG4642  196 YEGEFKNGQRHGQGTYTYADGD----RYEGEFKNGKR 228
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 6-143 1.89e-15

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 71.79  E-value: 1.89e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149999376   6 GSFTYSSGEEYRGEWKEGRRHGFGQLMFADGGTYLGHFENGLFNGFGVLTFSDGSRYEGEFAQGKFNGVGVFIRYDNMTF 85
Cdd:PLN03185  93 GYQRYPNGDVFEGSWIQGLQEGPGKYTWANGNVYLGDMKGGKMSGKGTLTWVSGDSYEGQWLDGMMHGFGVYTWSDGGCY 172

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 149999376  86 EGEFKNGRVDGFGLLtFPDGSHgIPRNEGLFENNkLLRREKCSAIVQRAQSASKSARN 143
Cdd:PLN03185 173 VGTWTRGLKDGKGVF-YPAGSR-VPAVQEFYLNA-LRKRGVLPDLRRQNQVLSSHNSE 227
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
5-120 2.60e-15

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 70.37  E-value: 2.60e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149999376   5 KGSFTYSSGEEYRGEWKEGRRHGFGQLMFADGGTYLGHFENGLFNGFGVLTFSDGSRYEGEFAQGKFNGVGVFIRYDNMT 84
Cdd:COG4642   93 GGEGGFGGGGGGGGGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDR 172

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 149999376  85 FEGEFKNGRVDGFGLLTFPDGShgipRNEGLFENNK 120
Cdd:COG4642  173 YEGEFKNGKRHGQGTLTYANGD----VYEGEFKNGQ 204
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 6-106 3.56e-14

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 68.32  E-value: 3.56e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149999376   6 GSFTYSSGEEYRGEWKEGRRHGFGQLMFADGGTYLGHFENGLFNGFGVLTFSDGSRYEGEFAQGKFNGVGVFIRYDNMTF 85
Cdd:PLN03185  70 GTYTGTDGTTYKGRWRLNLKHGLGYQRYPNGDVFEGSWIQGLQEGPGKYTWANGNVYLGDMKGGKMSGKGTLTWVSGDSY 149

                         90       100
                 ....*....|....*....|.
gi 149999376  86 EGEFKNGRVDGFGLLTFPDGS 106
Cdd:PLN03185 150 EGQWLDGMMHGFGVYTWSDGG 170
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 6-105 1.56e-13

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 66.40  E-value: 1.56e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149999376   6 GSFTYSSGEEYRGEWKEGRRHGFGQLMFADGGTYLGHFENGLFNGFGVLTFSDGSRYEGEFAQGKFNGVGVFIRYDNMTF 85
Cdd:PLN03185   1 GELVLSNGDFYSGSLLGNVPEGPGKYLWSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTY 80

                         90       100
                 ....*....|....*....|
gi 149999376  86 EGEFKNGRVDGFGLLTFPDG 105
Cdd:PLN03185  81 KGRWRLNLKHGLGYQRYPNG 100
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 5-105 9.56e-13

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 64.08  E-value: 9.56e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149999376   5 KGSFTYSSGEEYRGEWKEGRRHGFGQLMFADGGTYLGHFENGLFNGFGVLTFSDGSRYEGEFAQGKFNGVGVFIRYDNMT 84
Cdd:PLN03185  46 NGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLNLKHGLGYQRYPNGDVFEGSWIQGLQEGPGKYTWANGNV 125

                         90       100
                 ....*....|....*....|.
gi 149999376  85 FEGEFKNGRVDGFGLLTFPDG 105
Cdd:PLN03185 126 YLGDMKGGKMSGKGTLTWVSG 146
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
6-121 5.39e-11

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 58.43  E-value: 5.39e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149999376   6 GSFTYSSGEEYRGEWKEGRRHGFGQLMFADGGTYLGHFENGLFNGFGVLTFSDGSRYEGEFAQGKFNGVGVFIRYDNMTF 85
Cdd:COG4642   71 GVTAAGGGGGGGGGKGDGGDGGGGEGGFGGGGGGGGGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVY 150

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 149999376  86 EGEFKNGRVDGFGLLTFPDGShgipRNEGLFENNKL 121
Cdd:COG4642  151 EGEFKNGKPHGQGTLTYADGD----RYEGEFKNGKR 182
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 5-61 1.23e-08

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 52.53  E-value: 1.23e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 149999376   5 KGSFTYSSGEEYRGEWKEGRRHGFGQLMFADGGTYLGHFENGLFNGFGVLtFSDGSR 61
Cdd:PLN03185 138 KGTLTWVSGDSYEGQWLDGMMHGFGVYTWSDGGCYVGTWTRGLKDGKGVF-YPAGSR 193
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
16-35 1.08e-03

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 34.62  E-value: 1.08e-03
                           10        20
                   ....*....|....*....|
gi 149999376    16 YRGEWKEGRRHGFGQLMFAD 35
Cdd:smart00698   3 YEGEWRNGKRHGRGVYTYAN 22
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 16-38 1.26e-03

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 34.31  E-value: 1.26e-03
                          10        20
                  ....*....|....*....|...
gi 149999376   16 YRGEWKEGRRHGFGQLMFADGGT 38
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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