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Conserved domains on  [gi|1824615234|ref|NP_001092757|]
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magnesium transporter NIPA4 isoform 1 [Homo sapiens]

Protein Classification

DMT family transporter( domain architecture ID 581036)

DMT (drug/metabolite transporter) family transporter is an inner membrane protein involved in the transport of one or more of a variety of substrates such as amino acids, drugs, metabolites, and sugar phosphates, among others

Gene Ontology:  GO:0055085|GO:0005215|GO:0005886
PubMed:  11432728
TCDB:  2.A.7

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
EamA super family cl23754
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
54-348 2.61e-121

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


The actual alignment was detected with superfamily member pfam05653:

Pssm-ID: 474045  Cd Length: 295  Bit Score: 353.69  E-value: 2.61e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824615234  54 YGFYIGLGLAFLSSFLIGSSVILKKKGLLRLVATGATRAVDGGFGYLKDAMWWAGFLTMAAGEVANFGAYAFAPATVVTP 133
Cdd:pfam05653   1 TDFYIGVGLAISSSIFIGSSFIIKKKGLLRLARKGHPRAGAGGYGYLKEWLWWAGLLTMGVGEAANFAAYAFAPATLVTP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824615234 134 LGALSVLISAILSSYFLRESLNLLGKLGCVICVAGSTVMVIHAPEEEKVTTIMEMASKMKDTGFIVFAVLLLVSCLILIF 213
Cdd:pfam05653  81 LGALSVIISAVLASFFLKEKLNLSGKLGCVLCILGSTVIVIHAPKEQEIESLREVWHLLTDPGFLVYVILVVGVVLALIL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824615234 214 VIAPRYGQRNILIYIIICSVIGAFSVAAVKGLGITIKNFFQGLPVVRHPLPYILSLILALSLSTQVNFLNRALDIFNTSL 293
Cdd:pfam05653 161 YFEPRHGQTNIVVYITICSLIGSLTVMSVKAVGIAIKLTFTGKNQLTYPIAWILLLVMITCCVTQINYLNKALDIFNTSI 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1824615234 294 VFPIYYVFFTTVVVTSSIILFKEWYSMSAVDIAGTLSGFVTIILGVFMLHAFKDL 348
Cdd:pfam05653 241 VTPVYYVMFTTSVIIASAILFKEWLGMAFLDVAGELCGFFTVITGVFLLHAFRDK 295
 
Name Accession Description Interval E-value
Mg_trans_NIPA pfam05653
Magnesium transporter NIPA; NIPA (nonimprinted in Prader-Willi/Angelman syndrome) is a family ...
54-348 2.61e-121

Magnesium transporter NIPA; NIPA (nonimprinted in Prader-Willi/Angelman syndrome) is a family of integral membrane proteins which function as magnesium transporters.


Pssm-ID: 398984  Cd Length: 295  Bit Score: 353.69  E-value: 2.61e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824615234  54 YGFYIGLGLAFLSSFLIGSSVILKKKGLLRLVATGATRAVDGGFGYLKDAMWWAGFLTMAAGEVANFGAYAFAPATVVTP 133
Cdd:pfam05653   1 TDFYIGVGLAISSSIFIGSSFIIKKKGLLRLARKGHPRAGAGGYGYLKEWLWWAGLLTMGVGEAANFAAYAFAPATLVTP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824615234 134 LGALSVLISAILSSYFLRESLNLLGKLGCVICVAGSTVMVIHAPEEEKVTTIMEMASKMKDTGFIVFAVLLLVSCLILIF 213
Cdd:pfam05653  81 LGALSVIISAVLASFFLKEKLNLSGKLGCVLCILGSTVIVIHAPKEQEIESLREVWHLLTDPGFLVYVILVVGVVLALIL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824615234 214 VIAPRYGQRNILIYIIICSVIGAFSVAAVKGLGITIKNFFQGLPVVRHPLPYILSLILALSLSTQVNFLNRALDIFNTSL 293
Cdd:pfam05653 161 YFEPRHGQTNIVVYITICSLIGSLTVMSVKAVGIAIKLTFTGKNQLTYPIAWILLLVMITCCVTQINYLNKALDIFNTSI 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1824615234 294 VFPIYYVFFTTVVVTSSIILFKEWYSMSAVDIAGTLSGFVTIILGVFMLHAFKDL 348
Cdd:pfam05653 241 VTPVYYVMFTTSVIIASAILFKEWLGMAFLDVAGELCGFFTVITGVFLLHAFRDK 295
RibN COG2510
Riboflavin transporter RibN, EamA domain [Coenzyme transport and metabolism];
59-174 7.66e-07

Riboflavin transporter RibN, EamA domain [Coenzyme transport and metabolism];


Pssm-ID: 442000  Cd Length: 138  Bit Score: 48.26  E-value: 7.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824615234  59 GLGLAFLSSFLIGSSVILKKKGLLR--------------LVATGATRAVDGGFGYLKDA---MWWAGFL---TMAAGEVA 118
Cdd:COG2510     2 WLLLALLSAFFAGLTAIFAKIGLKGidpnlatfirtlvaLIFLLLILLVTGKLGELPELspkSWLFLLLsglATGLSWLF 81
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1824615234 119 NFGAYAFAPATVVTPLGALSVLISAILSSYFLRESLNLLGKLGCVICVAGSTVMVI 174
Cdd:COG2510    82 YFRALKLGPASIVAPIDKLSPVFTVLLSVLFLGERLTLKQIIGILLIVAGVILLSL 137
 
Name Accession Description Interval E-value
Mg_trans_NIPA pfam05653
Magnesium transporter NIPA; NIPA (nonimprinted in Prader-Willi/Angelman syndrome) is a family ...
54-348 2.61e-121

Magnesium transporter NIPA; NIPA (nonimprinted in Prader-Willi/Angelman syndrome) is a family of integral membrane proteins which function as magnesium transporters.


Pssm-ID: 398984  Cd Length: 295  Bit Score: 353.69  E-value: 2.61e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824615234  54 YGFYIGLGLAFLSSFLIGSSVILKKKGLLRLVATGATRAVDGGFGYLKDAMWWAGFLTMAAGEVANFGAYAFAPATVVTP 133
Cdd:pfam05653   1 TDFYIGVGLAISSSIFIGSSFIIKKKGLLRLARKGHPRAGAGGYGYLKEWLWWAGLLTMGVGEAANFAAYAFAPATLVTP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824615234 134 LGALSVLISAILSSYFLRESLNLLGKLGCVICVAGSTVMVIHAPEEEKVTTIMEMASKMKDTGFIVFAVLLLVSCLILIF 213
Cdd:pfam05653  81 LGALSVIISAVLASFFLKEKLNLSGKLGCVLCILGSTVIVIHAPKEQEIESLREVWHLLTDPGFLVYVILVVGVVLALIL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824615234 214 VIAPRYGQRNILIYIIICSVIGAFSVAAVKGLGITIKNFFQGLPVVRHPLPYILSLILALSLSTQVNFLNRALDIFNTSL 293
Cdd:pfam05653 161 YFEPRHGQTNIVVYITICSLIGSLTVMSVKAVGIAIKLTFTGKNQLTYPIAWILLLVMITCCVTQINYLNKALDIFNTSI 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1824615234 294 VFPIYYVFFTTVVVTSSIILFKEWYSMSAVDIAGTLSGFVTIILGVFMLHAFKDL 348
Cdd:pfam05653 241 VTPVYYVMFTTSVIIASAILFKEWLGMAFLDVAGELCGFFTVITGVFLLHAFRDK 295
RibN COG2510
Riboflavin transporter RibN, EamA domain [Coenzyme transport and metabolism];
59-174 7.66e-07

Riboflavin transporter RibN, EamA domain [Coenzyme transport and metabolism];


Pssm-ID: 442000  Cd Length: 138  Bit Score: 48.26  E-value: 7.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824615234  59 GLGLAFLSSFLIGSSVILKKKGLLR--------------LVATGATRAVDGGFGYLKDA---MWWAGFL---TMAAGEVA 118
Cdd:COG2510     2 WLLLALLSAFFAGLTAIFAKIGLKGidpnlatfirtlvaLIFLLLILLVTGKLGELPELspkSWLFLLLsglATGLSWLF 81
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1824615234 119 NFGAYAFAPATVVTPLGALSVLISAILSSYFLRESLNLLGKLGCVICVAGSTVMVI 174
Cdd:COG2510    82 YFRALKLGPASIVAPIDKLSPVFTVLLSVLFLGERLTLKQIIGILLIVAGVILLSL 137
EamA pfam00892
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
108-174 6.36e-04

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


Pssm-ID: 307170  Cd Length: 136  Bit Score: 39.49  E-value: 6.36e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1824615234 108 GFLTMAAGEVANFGAYAFAPATVVTPLGALSVLISAILSSYFLRESLNLLGKLGCVICVAGSTVMVI 174
Cdd:pfam00892  70 GVLGTFLGFLLYFYGLKYVSASNASVITSLSPVFTLILSVLLLGEKLTLKQLLGIVLILLGVLLILL 136
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
103-175 8.19e-04

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 40.98  E-value: 8.19e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1824615234 103 AMWWAGFLTMAAGEVANFGAYAFAPATVVTPLGALSVLISAILSSYFLRESLNLLGKLGCVICVAGSTVMVIH 175
Cdd:COG0697    67 LLLLRGLLGLALAFLLFFLALQYTPAALAALLLALAPLFVALLAALLLGERLSRRRWLGLLLGFAGVLLIVGP 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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