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Conserved domains on  [gi|154937350|ref|NP_001094346|]
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phytanoyl-CoA dioxygenase domain-containing protein 1 isoform a [Homo sapiens]

Protein Classification

phytanoyl-CoA dioxygenase family protein( domain architecture ID 10529740)

phytanoyl-CoA dioxygenase (PhyH) family protein similar to phytanoyl-CoA dioxygenase, which catalyzes the conversion of phytanoyl-CoA to 2-hydroxyphytanoyl-CoA

CATH:  2.60.120.620
EC:  1.14.-.-
Gene Ontology:  GO:0051213|GO:0046872

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
PhyH pfam05721
Phytanoyl-CoA dioxygenase (PhyH); This family is made up of several eukaryotic phytanoyl-CoA ...
12-259 9.05e-64

Phytanoyl-CoA dioxygenase (PhyH); This family is made up of several eukaryotic phytanoyl-CoA dioxygenase (PhyH) proteins, ectoine hydroxylases and a number of bacterial deoxygenases. PhyH is a peroxisomal enzyme catalysing the first step of phytanic acid alpha-oxidation. PhyH deficiency causes Refsum's disease (RD) which is an inherited neurological syndrome biochemically characterized by the accumulation of phytanic acid in plasma and tissues.


:

Pssm-ID: 399029  Cd Length: 213  Bit Score: 199.60  E-value: 9.05e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154937350   12 FQQDGFLVLEGFLSAEECVAMQQRIGEIVaemdvplhcrtefstqeeeqlraqgstDYFLSSGDKIRFFFEKGVFDEKGN 91
Cdd:pfam05721   1 FREDGYLVIEGFLSPEEVAALRAEAERLL---------------------------DRAAESGPDKDDFFDEKAAGDETG 53
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154937350   92 FLvppEKSINKIGHALHAhdpvfksithsFKVQTLARSLGLQMPVVV---QSMY----IFKQPHFGGEVSP-HQDASFLY 163
Cdd:pfam05721  54 LL---EKSITKRDHFLHP-----------FYLADLARAILGSPVYVAnvlQSMYqdlsIFKQPGTGGEVSPwHQDYTFLP 119
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154937350  164 TEPLGRVLGVWIAVEDATLENGCLWFIPGSHTSGVSRRMVRAPvgSAPGTSFLGSEPARDNSLFVPTPVQRGALVLIHGE 243
Cdd:pfam05721 120 TRPAELVVNVWIALDDATEENGCLRVIPGSHKWEVGPLARRLP--EDDYYAEDDEAPKRDEEPAVPVPMKAGDAVLFHPR 197
                         250
                  ....*....|....*.
gi 154937350  244 VVHKSKQNLSDRSRQA 259
Cdd:pfam05721 198 LLHGSGANRSDGSRRA 213
 
Name Accession Description Interval E-value
PhyH pfam05721
Phytanoyl-CoA dioxygenase (PhyH); This family is made up of several eukaryotic phytanoyl-CoA ...
12-259 9.05e-64

Phytanoyl-CoA dioxygenase (PhyH); This family is made up of several eukaryotic phytanoyl-CoA dioxygenase (PhyH) proteins, ectoine hydroxylases and a number of bacterial deoxygenases. PhyH is a peroxisomal enzyme catalysing the first step of phytanic acid alpha-oxidation. PhyH deficiency causes Refsum's disease (RD) which is an inherited neurological syndrome biochemically characterized by the accumulation of phytanic acid in plasma and tissues.


Pssm-ID: 399029  Cd Length: 213  Bit Score: 199.60  E-value: 9.05e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154937350   12 FQQDGFLVLEGFLSAEECVAMQQRIGEIVaemdvplhcrtefstqeeeqlraqgstDYFLSSGDKIRFFFEKGVFDEKGN 91
Cdd:pfam05721   1 FREDGYLVIEGFLSPEEVAALRAEAERLL---------------------------DRAAESGPDKDDFFDEKAAGDETG 53
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154937350   92 FLvppEKSINKIGHALHAhdpvfksithsFKVQTLARSLGLQMPVVV---QSMY----IFKQPHFGGEVSP-HQDASFLY 163
Cdd:pfam05721  54 LL---EKSITKRDHFLHP-----------FYLADLARAILGSPVYVAnvlQSMYqdlsIFKQPGTGGEVSPwHQDYTFLP 119
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154937350  164 TEPLGRVLGVWIAVEDATLENGCLWFIPGSHTSGVSRRMVRAPvgSAPGTSFLGSEPARDNSLFVPTPVQRGALVLIHGE 243
Cdd:pfam05721 120 TRPAELVVNVWIALDDATEENGCLRVIPGSHKWEVGPLARRLP--EDDYYAEDDEAPKRDEEPAVPVPMKAGDAVLFHPR 197
                         250
                  ....*....|....*.
gi 154937350  244 VVHKSKQNLSDRSRQA 259
Cdd:pfam05721 198 LLHGSGANRSDGSRRA 213
PhyH COG5285
Ectoine hydroxylase-related dioxygenase, phytanoyl-CoA dioxygenase (PhyH) family [Secondary ...
4-286 2.06e-48

Ectoine hydroxylase-related dioxygenase, phytanoyl-CoA dioxygenase (PhyH) family [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 444095  Cd Length: 237  Bit Score: 160.97  E-value: 2.06e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154937350   4 LSPSQLQKFQQDGFLVLEGFLSAEECVAMQQRIGEIVAEMdvplhcrtefstqeeeqlRAQGSTDYFLSSGDKIRFFFEk 83
Cdd:COG5285    2 LTDEQIAFFERDGYLVLRGVLSPEEVAALRAALDRLLAEA------------------PDEGDLEYSEADGGRLRRIYN- 62
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154937350  84 gvfdekgnflvppeksinkighaLHAHDPVFKSITHSFKVQTLARSLGLQMPVVVQSMYIFKQPHFGGEVSPHQDASFLY 163
Cdd:COG5285   63 -----------------------LHRRDPAFRDLARHPRILAVAEQLLGPDVRLHHSQLFFKPPGGGGATPWHQDFPYWP 119
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154937350 164 TEPlGRVLGVWIAVEDATLENGCLWFIPGSHTSGVSRRmvrapvgsAPGTSFLGsePARDNSLFVPTPVQRGALVLIHGE 243
Cdd:COG5285  120 LEP-PRAVTVWIALDDVTEENGCLRVVPGSHRWGLLPH--------RDDDGSLD--DALDEEEAVPVELKAGDVLIFHGL 188
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 154937350 244 VVHKSKQNLSDRSRQAYTFHLMeASGTTWSPENWLQPTAELPF 286
Cdd:COG5285  189 TLHGSGPNRSDRPRRALVLRYN-AADNRPQERQWLAVPRGLPE 230
 
Name Accession Description Interval E-value
PhyH pfam05721
Phytanoyl-CoA dioxygenase (PhyH); This family is made up of several eukaryotic phytanoyl-CoA ...
12-259 9.05e-64

Phytanoyl-CoA dioxygenase (PhyH); This family is made up of several eukaryotic phytanoyl-CoA dioxygenase (PhyH) proteins, ectoine hydroxylases and a number of bacterial deoxygenases. PhyH is a peroxisomal enzyme catalysing the first step of phytanic acid alpha-oxidation. PhyH deficiency causes Refsum's disease (RD) which is an inherited neurological syndrome biochemically characterized by the accumulation of phytanic acid in plasma and tissues.


Pssm-ID: 399029  Cd Length: 213  Bit Score: 199.60  E-value: 9.05e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154937350   12 FQQDGFLVLEGFLSAEECVAMQQRIGEIVaemdvplhcrtefstqeeeqlraqgstDYFLSSGDKIRFFFEKGVFDEKGN 91
Cdd:pfam05721   1 FREDGYLVIEGFLSPEEVAALRAEAERLL---------------------------DRAAESGPDKDDFFDEKAAGDETG 53
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154937350   92 FLvppEKSINKIGHALHAhdpvfksithsFKVQTLARSLGLQMPVVV---QSMY----IFKQPHFGGEVSP-HQDASFLY 163
Cdd:pfam05721  54 LL---EKSITKRDHFLHP-----------FYLADLARAILGSPVYVAnvlQSMYqdlsIFKQPGTGGEVSPwHQDYTFLP 119
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154937350  164 TEPLGRVLGVWIAVEDATLENGCLWFIPGSHTSGVSRRMVRAPvgSAPGTSFLGSEPARDNSLFVPTPVQRGALVLIHGE 243
Cdd:pfam05721 120 TRPAELVVNVWIALDDATEENGCLRVIPGSHKWEVGPLARRLP--EDDYYAEDDEAPKRDEEPAVPVPMKAGDAVLFHPR 197
                         250
                  ....*....|....*.
gi 154937350  244 VVHKSKQNLSDRSRQA 259
Cdd:pfam05721 198 LLHGSGANRSDGSRRA 213
PhyH COG5285
Ectoine hydroxylase-related dioxygenase, phytanoyl-CoA dioxygenase (PhyH) family [Secondary ...
4-286 2.06e-48

Ectoine hydroxylase-related dioxygenase, phytanoyl-CoA dioxygenase (PhyH) family [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 444095  Cd Length: 237  Bit Score: 160.97  E-value: 2.06e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154937350   4 LSPSQLQKFQQDGFLVLEGFLSAEECVAMQQRIGEIVAEMdvplhcrtefstqeeeqlRAQGSTDYFLSSGDKIRFFFEk 83
Cdd:COG5285    2 LTDEQIAFFERDGYLVLRGVLSPEEVAALRAALDRLLAEA------------------PDEGDLEYSEADGGRLRRIYN- 62
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154937350  84 gvfdekgnflvppeksinkighaLHAHDPVFKSITHSFKVQTLARSLGLQMPVVVQSMYIFKQPHFGGEVSPHQDASFLY 163
Cdd:COG5285   63 -----------------------LHRRDPAFRDLARHPRILAVAEQLLGPDVRLHHSQLFFKPPGGGGATPWHQDFPYWP 119
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154937350 164 TEPlGRVLGVWIAVEDATLENGCLWFIPGSHTSGVSRRmvrapvgsAPGTSFLGsePARDNSLFVPTPVQRGALVLIHGE 243
Cdd:COG5285  120 LEP-PRAVTVWIALDDVTEENGCLRVVPGSHRWGLLPH--------RDDDGSLD--DALDEEEAVPVELKAGDVLIFHGL 188
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 154937350 244 VVHKSKQNLSDRSRQAYTFHLMeASGTTWSPENWLQPTAELPF 286
Cdd:COG5285  189 TLHGSGPNRSDRPRRALVLRYN-AADNRPQERQWLAVPRGLPE 230
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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