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Conserved domains on  [gi|157426862|ref|NP_001098719|]
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transmembrane channel-like protein 5 isoform b [Homo sapiens]

Protein Classification

transmembrane channel-like protein( domain architecture ID 10544697)

transmembrane channel-like protein may function as an ion channel, transporter, or modifier

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TMC pfam07810
TMC domain; These sequences are similar to a region conserved amongst various protein products ...
724-830 1.52e-54

TMC domain; These sequences are similar to a region conserved amongst various protein products of the transmembrane channel-like (TMC) gene family, such as Transmembrane channel-like protein 3 and EVIN2 - this region is termed the TMC domain. Mutations in these genes are implicated in a number of human conditions, such as deafness and epidermodysplasia verruciformis. TMC proteins are thought to have important cellular roles, and may be modifiers of ion channels or transporters.


:

Pssm-ID: 462275  Cd Length: 111  Bit Score: 184.27  E-value: 1.52e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157426862  724 CWETLIGQDIYRLLLMDFVFSLVNSFLGEFLRRIIGM----QLITSLGLQEFDIARNVLELIYAQTLVWIGIFFCPLLPF 799
Cdd:pfam07810   1 CWETYVGQELYKLVIFDFLVTLLVTLLVEFPRKLLVRkcngCLEKLLGKQEFDIAKNVLDLIYNQTLCWLGLFFSPLLPL 80
                          90       100       110
                  ....*....|....*....|....*....|.
gi 157426862  800 IQMIMLFIMFYSKNISLMMNFQPPSKAWRAS 830
Cdd:pfam07810  81 INVIKLFILFYVKKFSLLYNCQPPSRPFRAS 111
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
36-293 1.95e-05

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 48.63  E-value: 1.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157426862   36 PDVPGPLNNPDYPGTRSNPYSVASRTRPDYPGSLAEPNYPRSLSNPDYSGTRSNAYSAASRTSPDHPTSLPEPDYSEFQS 115
Cdd:PHA03307  194 PPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEAS 273
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157426862  116 HPYH---RASSRQPDYPGSQRNPDFAGSSSSGNYAGSRthPDHFGSLEPDYPG--AQSNSDHPGPRANLNHPGSrknlEH 190
Cdd:PHA03307  274 GWNGpssRPGPASSSSSPRERSPSPSPSSPGSGPAPSS--PRASSSSSSSRESssSSTSSSSESSRGAAVSPGP----SP 347
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157426862  191 TSfrinPYADSLGKPDYPGADIQPNSPPFFGePDYPSAEDNQNLPSTWRePDYSDAENGHDYGSSETPKMTRGVLSRTSS 270
Cdd:PHA03307  348 SR----SPSPSRPPPPADPSSPRKRPRPSRA-PSSPAASAGRPTRRRAR-AAVAGRARRRDATGRFPAGRPRPSPLDAGA 421
                         250       260
                  ....*....|....*....|....*
gi 157426862  271 IQPSF--RHRSDDPVGSLWGENDYP 293
Cdd:PHA03307  422 ASGAFyaRYPLLTPSGEPWPGSPPP 446
 
Name Accession Description Interval E-value
TMC pfam07810
TMC domain; These sequences are similar to a region conserved amongst various protein products ...
724-830 1.52e-54

TMC domain; These sequences are similar to a region conserved amongst various protein products of the transmembrane channel-like (TMC) gene family, such as Transmembrane channel-like protein 3 and EVIN2 - this region is termed the TMC domain. Mutations in these genes are implicated in a number of human conditions, such as deafness and epidermodysplasia verruciformis. TMC proteins are thought to have important cellular roles, and may be modifiers of ion channels or transporters.


Pssm-ID: 462275  Cd Length: 111  Bit Score: 184.27  E-value: 1.52e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157426862  724 CWETLIGQDIYRLLLMDFVFSLVNSFLGEFLRRIIGM----QLITSLGLQEFDIARNVLELIYAQTLVWIGIFFCPLLPF 799
Cdd:pfam07810   1 CWETYVGQELYKLVIFDFLVTLLVTLLVEFPRKLLVRkcngCLEKLLGKQEFDIAKNVLDLIYNQTLCWLGLFFSPLLPL 80
                          90       100       110
                  ....*....|....*....|....*....|.
gi 157426862  800 IQMIMLFIMFYSKNISLMMNFQPPSKAWRAS 830
Cdd:pfam07810  81 INVIKLFILFYVKKFSLLYNCQPPSRPFRAS 111
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
36-293 1.95e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 48.63  E-value: 1.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157426862   36 PDVPGPLNNPDYPGTRSNPYSVASRTRPDYPGSLAEPNYPRSLSNPDYSGTRSNAYSAASRTSPDHPTSLPEPDYSEFQS 115
Cdd:PHA03307  194 PPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEAS 273
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157426862  116 HPYH---RASSRQPDYPGSQRNPDFAGSSSSGNYAGSRthPDHFGSLEPDYPG--AQSNSDHPGPRANLNHPGSrknlEH 190
Cdd:PHA03307  274 GWNGpssRPGPASSSSSPRERSPSPSPSSPGSGPAPSS--PRASSSSSSSRESssSSTSSSSESSRGAAVSPGP----SP 347
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157426862  191 TSfrinPYADSLGKPDYPGADIQPNSPPFFGePDYPSAEDNQNLPSTWRePDYSDAENGHDYGSSETPKMTRGVLSRTSS 270
Cdd:PHA03307  348 SR----SPSPSRPPPPADPSSPRKRPRPSRA-PSSPAASAGRPTRRRAR-AAVAGRARRRDATGRFPAGRPRPSPLDAGA 421
                         250       260
                  ....*....|....*....|....*
gi 157426862  271 IQPSF--RHRSDDPVGSLWGENDYP 293
Cdd:PHA03307  422 ASGAFyaRYPLLTPSGEPWPGSPPP 446
ABC-2_lan_permease-like cd21809
lantibiotic immunity ABC transporter permease (also called ABC-2 transporter permease) subunit ...
785-859 6.94e-03

lantibiotic immunity ABC transporter permease (also called ABC-2 transporter permease) subunit and similar proteins; This subfamily contains lantibiotic ABC transporter permease subunits which are highly hydrophobic, integral membrane proteins, and part of the bacitracin ABC transport system that confers resistance to the Gram-positive bacteria in which this system operates, particularly to type-A lantibiotics. Lantibiotics are small peptides, produced by Gram-positive bacteria, which are ribosomally-synthesized as pre-peptides and act by disrupting membrane integrity. Genes encoding the lantibiotic ABC transporter subunits are highly organized in operons containing all the genes required for maturation, transport, immunity, and synthesis. For example, in Lactococcus lactis, the lantibiotic nisin is active against other Gram-positive bacteria via various modes of actions; however, its self-protection against the pore-forming nisin is mediated by the ABC transporter composed of NisF, NisE and NisG; the NisG permease subunit transports nisin to the surface and expels it from the membrane. This family includes mostly uncharacterized transport permease subunits that transport lantibiotics to the surface and expel them from the membrane.


Pssm-ID: 409634  Cd Length: 235  Bit Score: 39.10  E-value: 6.94e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157426862 785 TLVWIGIFFCPLLPFIQMIMLFIMFYSKnislMMNFQPPSKAWraSQMMTFFIfLLFFPSFTGVLCTLaitIWRI 859
Cdd:cd21809    9 SKIWLLVLLAPLLAVLLGLLNFLRNKDI----LVKDNPWWSLL--TQVVLFYG-LLFLPLLIGILASL---VCRI 73
 
Name Accession Description Interval E-value
TMC pfam07810
TMC domain; These sequences are similar to a region conserved amongst various protein products ...
724-830 1.52e-54

TMC domain; These sequences are similar to a region conserved amongst various protein products of the transmembrane channel-like (TMC) gene family, such as Transmembrane channel-like protein 3 and EVIN2 - this region is termed the TMC domain. Mutations in these genes are implicated in a number of human conditions, such as deafness and epidermodysplasia verruciformis. TMC proteins are thought to have important cellular roles, and may be modifiers of ion channels or transporters.


Pssm-ID: 462275  Cd Length: 111  Bit Score: 184.27  E-value: 1.52e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157426862  724 CWETLIGQDIYRLLLMDFVFSLVNSFLGEFLRRIIGM----QLITSLGLQEFDIARNVLELIYAQTLVWIGIFFCPLLPF 799
Cdd:pfam07810   1 CWETYVGQELYKLVIFDFLVTLLVTLLVEFPRKLLVRkcngCLEKLLGKQEFDIAKNVLDLIYNQTLCWLGLFFSPLLPL 80
                          90       100       110
                  ....*....|....*....|....*....|.
gi 157426862  800 IQMIMLFIMFYSKNISLMMNFQPPSKAWRAS 830
Cdd:pfam07810  81 INVIKLFILFYVKKFSLLYNCQPPSRPFRAS 111
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
36-293 1.95e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 48.63  E-value: 1.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157426862   36 PDVPGPLNNPDYPGTRSNPYSVASRTRPDYPGSLAEPNYPRSLSNPDYSGTRSNAYSAASRTSPDHPTSLPEPDYSEFQS 115
Cdd:PHA03307  194 PPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEAS 273
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157426862  116 HPYH---RASSRQPDYPGSQRNPDFAGSSSSGNYAGSRthPDHFGSLEPDYPG--AQSNSDHPGPRANLNHPGSrknlEH 190
Cdd:PHA03307  274 GWNGpssRPGPASSSSSPRERSPSPSPSSPGSGPAPSS--PRASSSSSSSRESssSSTSSSSESSRGAAVSPGP----SP 347
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157426862  191 TSfrinPYADSLGKPDYPGADIQPNSPPFFGePDYPSAEDNQNLPSTWRePDYSDAENGHDYGSSETPKMTRGVLSRTSS 270
Cdd:PHA03307  348 SR----SPSPSRPPPPADPSSPRKRPRPSRA-PSSPAASAGRPTRRRAR-AAVAGRARRRDATGRFPAGRPRPSPLDAGA 421
                         250       260
                  ....*....|....*....|....*
gi 157426862  271 IQPSF--RHRSDDPVGSLWGENDYP 293
Cdd:PHA03307  422 ASGAFyaRYPLLTPSGEPWPGSPPP 446
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
10-332 3.81e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 47.86  E-value: 3.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157426862   10 SEEDPDYPDYSGSQnrtqGYLKTQGYPDVPGPLNNPDYPGTRSNPYSVASrtrpdyPGSLAEPNYPRSLSNPDYSGTRSN 89
Cdd:PHA03307   27 TPGDAADDLLSGSQ----GQLVSDSAELAAVTVVAGAAACDRFEPPTGPP------PGPGTEAPANESRSTPTWSLSTLA 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157426862   90 AYSAASRTSPDHPTSLPEPdysefqshPYHRASsrQPDYPGSQRNPDfagSSSSGNYAGSRTHPDHFGSLEPDYPGAQSN 169
Cdd:PHA03307   97 PASPAREGSPTPPGPSSPD--------PPPPTP--PPASPPPSPAPD---LSEMLRPVGSPGPPPAASPPAAGASPAAVA 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157426862  170 SDHPGPRANLNHPGSRKNLEHTSfrINPYADSLGKPDYPGAdiqPNSPPFFGEPDYPSAEDNQnlPSTWREPDYSDAENG 249
Cdd:PHA03307  164 SDAASSRQAALPLSSPEETARAP--SSPPAEPPPSTPPAAA---SPRPPRRSSPISASASSPA--PAPGRSAADDAGASS 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157426862  250 HDYGSSETPKMTRGVLSRTSSIQPS-FRHRSDDPVGSLWGENDYPEGIEMASMEMANSYGHSLPGAPGSGYVNPA--YVG 326
Cdd:PHA03307  237 SDSSSSESSGCGWGPENECPLPRPApITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSprASS 316

                  ....*.
gi 157426862  327 ESGPVH 332
Cdd:PHA03307  317 SSSSSR 322
dnaA PRK14086
chromosomal replication initiator protein DnaA;
92-337 7.70e-05

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 46.36  E-value: 7.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157426862  92 SAASRTSPDHPT-SLPEPDYSEFQSHPYHRASSRQPDYPGSQRNPDfagssssgnyagSRthpdhfgslePDYPGAQSNS 170
Cdd:PRK14086  96 APPPPHARRTSEpELPRPGRRPYEGYGGPRADDRPPGLPRQDQLPT------------AR----------PAYPAYQQRP 153
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157426862 171 DhPGPranlnHPGsrknlehTSFRINPYADSLGKPdyPGADiqpnsppffgepdYPSAEDNQNLPSTWREP-DYSDAENG 249
Cdd:PRK14086 154 E-PGA-----WPR-------AADDYGWQQQRLGFP--PRAP-------------YASPASYAPEQERDREPyDAGRPEYD 205
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157426862 250 HDYGSSETPkmtrgvlsRTSSIQPSfRHRSDDPVGSLWGENDyPEGIEMASMEMANSYGHSLPGAPGSGYVNPAYVGESG 329
Cdd:PRK14086 206 QRRRDYDHP--------RPDWDRPR-RDRTDRPEPPPGAGHV-HRGGPGPPERDDAPVVPIRPSAPGPLAAQPAPAPGPG 275

                 ....*...
gi 157426862 330 PVHAYGNP 337
Cdd:PRK14086 276 EPTARLNP 283
ABC-2_lan_permease-like cd21809
lantibiotic immunity ABC transporter permease (also called ABC-2 transporter permease) subunit ...
785-859 6.94e-03

lantibiotic immunity ABC transporter permease (also called ABC-2 transporter permease) subunit and similar proteins; This subfamily contains lantibiotic ABC transporter permease subunits which are highly hydrophobic, integral membrane proteins, and part of the bacitracin ABC transport system that confers resistance to the Gram-positive bacteria in which this system operates, particularly to type-A lantibiotics. Lantibiotics are small peptides, produced by Gram-positive bacteria, which are ribosomally-synthesized as pre-peptides and act by disrupting membrane integrity. Genes encoding the lantibiotic ABC transporter subunits are highly organized in operons containing all the genes required for maturation, transport, immunity, and synthesis. For example, in Lactococcus lactis, the lantibiotic nisin is active against other Gram-positive bacteria via various modes of actions; however, its self-protection against the pore-forming nisin is mediated by the ABC transporter composed of NisF, NisE and NisG; the NisG permease subunit transports nisin to the surface and expels it from the membrane. This family includes mostly uncharacterized transport permease subunits that transport lantibiotics to the surface and expel them from the membrane.


Pssm-ID: 409634  Cd Length: 235  Bit Score: 39.10  E-value: 6.94e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157426862 785 TLVWIGIFFCPLLPFIQMIMLFIMFYSKnislMMNFQPPSKAWraSQMMTFFIfLLFFPSFTGVLCTLaitIWRI 859
Cdd:cd21809    9 SKIWLLVLLAPLLAVLLGLLNFLRNKDI----LVKDNPWWSLL--TQVVLFYG-LLFLPLLIGILASL---VCRI 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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