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Conserved domains on  [gi|157786962|ref|NP_001099415|]
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nanos homolog 3 [Rattus norvegicus]

Protein Classification

nanos family protein( domain architecture ID 10530272)

nanos family protein contains a zinc finger domain (called nanos RNA binding domain), similar to Drosophila melanogaster protein nanos, a maternal RNA-binding protein that is required for germ cells proliferation and self-renewal

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
zf-nanos pfam05741
Nanos RNA binding domain; This family consists of several conserved novel zinc finger domains ...
57-110 1.40e-31

Nanos RNA binding domain; This family consists of several conserved novel zinc finger domains found in the eukaryotic proteins Nanos and Xcat-2. In Drosophila melanogaster, Nanos functions as a localized determinant of posterior pattern. Nanos RNA is localized to the posterior pole of the maturing egg cell and encodes a protein that emanates from this localized source. Nanos acts as a translational repressor and thereby establishes a gradient of the morphogen Hunchback. Xcat-2 is found in the vegetal cortical region and is inherited by the vegetal blasomeres during development, and is degraded very early in development. The localized and maternally restricted expression of Xcat-2 RNA suggests a role for its protein in setting up regional differences in gene expression that occur early in development.


:

Pssm-ID: 461728  Cd Length: 54  Bit Score: 108.05  E-value: 1.40e-31
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 157786962   57 CSFCKHNGESRAIYQSHVLKDEAGRVLCPILRDYVCPQCGATQEHAHTRRFCPL 110
Cdd:pfam05741   1 CVFCKNNGESREVYSSHTLKDPDGRVTCPVLRKYVCPICGATGDNAHTIKYCPK 54
 
Name Accession Description Interval E-value
zf-nanos pfam05741
Nanos RNA binding domain; This family consists of several conserved novel zinc finger domains ...
57-110 1.40e-31

Nanos RNA binding domain; This family consists of several conserved novel zinc finger domains found in the eukaryotic proteins Nanos and Xcat-2. In Drosophila melanogaster, Nanos functions as a localized determinant of posterior pattern. Nanos RNA is localized to the posterior pole of the maturing egg cell and encodes a protein that emanates from this localized source. Nanos acts as a translational repressor and thereby establishes a gradient of the morphogen Hunchback. Xcat-2 is found in the vegetal cortical region and is inherited by the vegetal blasomeres during development, and is degraded very early in development. The localized and maternally restricted expression of Xcat-2 RNA suggests a role for its protein in setting up regional differences in gene expression that occur early in development.


Pssm-ID: 461728  Cd Length: 54  Bit Score: 108.05  E-value: 1.40e-31
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 157786962   57 CSFCKHNGESRAIYQSHVLKDEAGRVLCPILRDYVCPQCGATQEHAHTRRFCPL 110
Cdd:pfam05741   1 CVFCKNNGESREVYSSHTLKDPDGRVTCPVLRKYVCPICGATGDNAHTIKYCPK 54
 
Name Accession Description Interval E-value
zf-nanos pfam05741
Nanos RNA binding domain; This family consists of several conserved novel zinc finger domains ...
57-110 1.40e-31

Nanos RNA binding domain; This family consists of several conserved novel zinc finger domains found in the eukaryotic proteins Nanos and Xcat-2. In Drosophila melanogaster, Nanos functions as a localized determinant of posterior pattern. Nanos RNA is localized to the posterior pole of the maturing egg cell and encodes a protein that emanates from this localized source. Nanos acts as a translational repressor and thereby establishes a gradient of the morphogen Hunchback. Xcat-2 is found in the vegetal cortical region and is inherited by the vegetal blasomeres during development, and is degraded very early in development. The localized and maternally restricted expression of Xcat-2 RNA suggests a role for its protein in setting up regional differences in gene expression that occur early in development.


Pssm-ID: 461728  Cd Length: 54  Bit Score: 108.05  E-value: 1.40e-31
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 157786962   57 CSFCKHNGESRAIYQSHVLKDEAGRVLCPILRDYVCPQCGATQEHAHTRRFCPL 110
Cdd:pfam05741   1 CVFCKNNGESREVYSSHTLKDPDGRVTCPVLRKYVCPICGATGDNAHTIKYCPK 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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