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Conserved domains on  [gi|157817282|ref|NP_001099597|]
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phosphoribosyltransferase domain-containing protein 1 [Rattus norvegicus]

Protein Classification

type I phosphoribosyltransferase( domain architecture ID 27)

type I phosphoribosyltransferase similar to phosphoribosyltransferases with specificities for hypoxanthine, guanine, and/or xanthine

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRTases_typeI super family cl00309
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 2-224 6.27e-80

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


The actual alignment was detected with superfamily member PTZ00149:

Pssm-ID: 444823  Cd Length: 241  Bit Score: 239.28  E-value: 6.27e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817282   2 AGSSEKAPDSGRG----VVLMDNwPGYDLDLFTYPQHYYGDLECVLIPHGIIVDRIERLAKDIMKDIGYHDILVLCVLKG 77
Cdd:PTZ00149  13 ATSSYDYVGAGEDrkepIYIKDD-DFYDLDSFLIPPHYKNYLTKILLPNGLIKDRVEKLAYDIKQVYGNEELHILCILKG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817282  78 GYKFCADLVEHLKNISRNSDRFVSMKV---DFIRLKSYKNDRSMGEMQIIGgEDLSTLAGKNVLIVEDVVGTGRTMEALL 154
Cdd:PTZ00149  92 SRGFFSALVDYLNRIHNYSSTESPKPPyqeHYVRVKSYCNDESTGKLEIVS-DDLSCLKDKHVLIVEDIIDTGNTLVKFC 170

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817282 155 SSIEKYKPNMVKVASLLVKRTARSDSFRPDYAGFEIPDVFVVGYALDYNEYFRDLNHICVINEHGKEKYR 224
Cdd:PTZ00149 171 EYLKKFEPKTIRIATLFEKRTPLSNGFKGDFVGFSIPDHFVVGYCLDYNEHFRDLDHVAVLNDEGIKKYK 240
 
Name Accession Description Interval E-value
PTZ00149 PTZ00149
hypoxanthine phosphoribosyltransferase; Provisional
 2-224 6.27e-80

hypoxanthine phosphoribosyltransferase; Provisional


Pssm-ID: 240293  Cd Length: 241  Bit Score: 239.28  E-value: 6.27e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817282   2 AGSSEKAPDSGRG----VVLMDNwPGYDLDLFTYPQHYYGDLECVLIPHGIIVDRIERLAKDIMKDIGYHDILVLCVLKG 77
Cdd:PTZ00149  13 ATSSYDYVGAGEDrkepIYIKDD-DFYDLDSFLIPPHYKNYLTKILLPNGLIKDRVEKLAYDIKQVYGNEELHILCILKG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817282  78 GYKFCADLVEHLKNISRNSDRFVSMKV---DFIRLKSYKNDRSMGEMQIIGgEDLSTLAGKNVLIVEDVVGTGRTMEALL 154
Cdd:PTZ00149  92 SRGFFSALVDYLNRIHNYSSTESPKPPyqeHYVRVKSYCNDESTGKLEIVS-DDLSCLKDKHVLIVEDIIDTGNTLVKFC 170

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817282 155 SSIEKYKPNMVKVASLLVKRTARSDSFRPDYAGFEIPDVFVVGYALDYNEYFRDLNHICVINEHGKEKYR 224
Cdd:PTZ00149 171 EYLKKFEPKTIRIATLFEKRTPLSNGFKGDFVGFSIPDHFVVGYCLDYNEHFRDLDHVAVLNDEGIKKYK 240
HGPRTase TIGR01203
hypoxanthine phosphoribosyltransferase; Alternate name: hypoxanthine-guanine ...
 42-215 1.06e-59

hypoxanthine phosphoribosyltransferase; Alternate name: hypoxanthine-guanine phosphoribosyltransferase. Sequence differences as small as a single residue can affect whether members of this family act on hypoxanthine and guanine or hypoxanthine only. The designation of this model as equivalog reflects hypoxanthine specificity and does not reflect whether or not guanine can replace hypoxanthine. [Purines, pyrimidines, nucleosides, and nucleotides, Salvage of nucleosides and nucleotides]


Pssm-ID: 273497  Cd Length: 166  Bit Score: 185.14  E-value: 1.06e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817282   42 VLIPHGIIVDRIERLAKDIMKDIGYHDILVLCVLKGGYKFCADLVEHLKnisrnsdrfVSMKVDFIRLKSYKND-RSMGE 120
Cdd:TIGR01203   1 VLIPEEQIKARIAELAKQITEDYAGKPLVLLCVLKGSFPFFADLIRYIA---------VPVQVDFMAVSSYGNGmQSSGD 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817282  121 MQIIGGEDLSTLaGKNVLIVEDVVGTGRTMEALLSSIEKYKPNMVKVASLLVKRTARSDSFRPDYAGFEIPDVFVVGYAL 200
Cdd:TIGR01203  72 VKILKDLDLDIK-GKDVLIVEDIVDTGLTLQYLLDLLKARKPKSLKIVTLLDKPSRRKVDVKVDFVGFEIPDKFVVGYGL 150

                         170
                  ....*....|....*
gi 157817282  201 DYNEYFRDLNHICVI 215
Cdd:TIGR01203 151 DYAERYRNLPYIGVL 165
HptA COG0634
Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism]; ...
 42-218 3.71e-54

Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism]; Hypoxanthine-guanine phosphoribosyltransferase is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 440399  Cd Length: 176  Bit Score: 171.36  E-value: 3.71e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817282  42 VLIPHGIIVDRIERLAKDIMKDIGYHDILVLCVLKGGYKFCADLVEHLKnisrnsdrfVSMKVDFIRLKSYKN-DRSMGE 120
Cdd:COG0634    8 VLISEEEIQARVKELAAQITADYAGKEPLVVGVLKGAFVFMADLLRALD---------FPLEIDFMHVSSYGGgTESSGE 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817282 121 MQIIGGEDLStLAGKNVLIVEDVVGTGRTMEALLSSIEKYKPNMVKVASLLVKRTARSDSFRPDYAGFEIPDVFVVGYAL 200
Cdd:COG0634   79 VRILKDLDED-IEGRDVLIVEDIIDTGLTLSYLLELLKSRGPASVKIATLLDKPERRKVDVPADYVGFEIPDEFVVGYGL 157

                        170
                 ....*....|....*...
gi 157817282 201 DYNEYFRDLNHICVINEH 218
Cdd:COG0634  158 DYAEYYRNLPYIYALKPE 175
Pribosyltran pfam00156
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl ...
 46-203 9.39e-19

Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1. Amidophosphoribosyltransferase EC:2.4.2.14. Orotate phosphoribosyl-transferase EC:2.4.2.10. Uracil phosphoribosyl-transferase EC:2.4.2.9. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain.


Pssm-ID: 425489 [Multi-domain]  Cd Length: 150  Bit Score: 79.33  E-value: 9.39e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817282   46 HGIIVDRIERLAKDIMKDIGYHDILVLCVLKGGYKFCADLVEHLKNisrnsdrfvsmKVDFIRLKSYkNDRSMGEMQIIg 125
Cdd:pfam00156   8 NPAILKAVARLAAQINEDYGGKPDVVVGILRGGLPFAGILARRLDV-----------PLAFVRKVSY-NPDTSEVMKTS- 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157817282  126 gEDLSTLAGKNVLIVEDVVGTGRTMEALLSSIEKYKPNMVKVASLLVKRTARSDSFRPDYAGFEiPDVFVVGYALDYN 203
Cdd:pfam00156  75 -SALPDLKGKTVLIVDDILDTGGTLLKVLELLKNVGPKEVKIAVLIDKPAGTEPKDKYDKRVDD-WIVFVVGFGLDER 150
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 53-189 1.52e-17

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 75.51  E-value: 1.52e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817282  53 IERLAKDIMKDIGyHDILVLCVLKGGYKFCADLVEHLKnisrnsdrfvsMKVDFIRLKSYKNDRSMGEMQIIGGEDLSTL 132
Cdd:cd06223    2 GRLLAEEIREDLL-EPDVVVGILRGGLPLAAALARALG-----------LPLAFIRKERKGPGRTPSEPYGLELPLGGDV 69

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157817282 133 AGKNVLIVEDVVGTGRTMEALLSSIEKYKPNMVKVASLLVKRTAR----SDSFRPDYAGFE 189
Cdd:cd06223   70 KGKRVLLVDDVIATGGTLLAAIELLKEAGAKVVGVAVLLDKPEGGarelASPGDPVYSLFT 130
 
Name Accession Description Interval E-value
PTZ00149 PTZ00149
hypoxanthine phosphoribosyltransferase; Provisional
 2-224 6.27e-80

hypoxanthine phosphoribosyltransferase; Provisional


Pssm-ID: 240293  Cd Length: 241  Bit Score: 239.28  E-value: 6.27e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817282   2 AGSSEKAPDSGRG----VVLMDNwPGYDLDLFTYPQHYYGDLECVLIPHGIIVDRIERLAKDIMKDIGYHDILVLCVLKG 77
Cdd:PTZ00149  13 ATSSYDYVGAGEDrkepIYIKDD-DFYDLDSFLIPPHYKNYLTKILLPNGLIKDRVEKLAYDIKQVYGNEELHILCILKG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817282  78 GYKFCADLVEHLKNISRNSDRFVSMKV---DFIRLKSYKNDRSMGEMQIIGgEDLSTLAGKNVLIVEDVVGTGRTMEALL 154
Cdd:PTZ00149  92 SRGFFSALVDYLNRIHNYSSTESPKPPyqeHYVRVKSYCNDESTGKLEIVS-DDLSCLKDKHVLIVEDIIDTGNTLVKFC 170

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817282 155 SSIEKYKPNMVKVASLLVKRTARSDSFRPDYAGFEIPDVFVVGYALDYNEYFRDLNHICVINEHGKEKYR 224
Cdd:PTZ00149 171 EYLKKFEPKTIRIATLFEKRTPLSNGFKGDFVGFSIPDHFVVGYCLDYNEHFRDLDHVAVLNDEGIKKYK 240
HGPRTase TIGR01203
hypoxanthine phosphoribosyltransferase; Alternate name: hypoxanthine-guanine ...
 42-215 1.06e-59

hypoxanthine phosphoribosyltransferase; Alternate name: hypoxanthine-guanine phosphoribosyltransferase. Sequence differences as small as a single residue can affect whether members of this family act on hypoxanthine and guanine or hypoxanthine only. The designation of this model as equivalog reflects hypoxanthine specificity and does not reflect whether or not guanine can replace hypoxanthine. [Purines, pyrimidines, nucleosides, and nucleotides, Salvage of nucleosides and nucleotides]


Pssm-ID: 273497  Cd Length: 166  Bit Score: 185.14  E-value: 1.06e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817282   42 VLIPHGIIVDRIERLAKDIMKDIGYHDILVLCVLKGGYKFCADLVEHLKnisrnsdrfVSMKVDFIRLKSYKND-RSMGE 120
Cdd:TIGR01203   1 VLIPEEQIKARIAELAKQITEDYAGKPLVLLCVLKGSFPFFADLIRYIA---------VPVQVDFMAVSSYGNGmQSSGD 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817282  121 MQIIGGEDLSTLaGKNVLIVEDVVGTGRTMEALLSSIEKYKPNMVKVASLLVKRTARSDSFRPDYAGFEIPDVFVVGYAL 200
Cdd:TIGR01203  72 VKILKDLDLDIK-GKDVLIVEDIVDTGLTLQYLLDLLKARKPKSLKIVTLLDKPSRRKVDVKVDFVGFEIPDKFVVGYGL 150

                         170
                  ....*....|....*
gi 157817282  201 DYNEYFRDLNHICVI 215
Cdd:TIGR01203 151 DYAERYRNLPYIGVL 165
HptA COG0634
Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism]; ...
 42-218 3.71e-54

Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism]; Hypoxanthine-guanine phosphoribosyltransferase is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 440399  Cd Length: 176  Bit Score: 171.36  E-value: 3.71e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817282  42 VLIPHGIIVDRIERLAKDIMKDIGYHDILVLCVLKGGYKFCADLVEHLKnisrnsdrfVSMKVDFIRLKSYKN-DRSMGE 120
Cdd:COG0634    8 VLISEEEIQARVKELAAQITADYAGKEPLVVGVLKGAFVFMADLLRALD---------FPLEIDFMHVSSYGGgTESSGE 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817282 121 MQIIGGEDLStLAGKNVLIVEDVVGTGRTMEALLSSIEKYKPNMVKVASLLVKRTARSDSFRPDYAGFEIPDVFVVGYAL 200
Cdd:COG0634   79 VRILKDLDED-IEGRDVLIVEDIIDTGLTLSYLLELLKSRGPASVKIATLLDKPERRKVDVPADYVGFEIPDEFVVGYGL 157

                        170
                 ....*....|....*...
gi 157817282 201 DYNEYFRDLNHICVINEH 218
Cdd:COG0634  158 DYAEYYRNLPYIYALKPE 175
PLN02238 PLN02238
hypoxanthine phosphoribosyltransferase
 35-219 1.82e-40

hypoxanthine phosphoribosyltransferase


Pssm-ID: 215132  Cd Length: 189  Bit Score: 136.71  E-value: 1.82e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817282  35 YYGDLECVLIPHGIIVDRIERLAKDIMKDIGYHDILVLCVLKGGYKFCADLVEHLKNISRnsdrfvSMKVDFIRLKSYKN 114
Cdd:PLN02238   3 YEVDIEKVLWTAEDISARVAELAAQIASDYAGKSPVVLGVATGAFMFLADLVRAIQPLPR------GLTVDFIRASSYGG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817282 115 DRSMGEMQIIGGEDLS-TLAGKNVLIVEDVVGTGRTMEALLSSIEKYKPNMVKVASLLVKRTARSDSFR-----PDYAGF 188
Cdd:PLN02238  77 GTESSGVAKVSGADLKiDVKGKHVLLVEDIVDTGNTLSALVAHLEAKGAASVSVCALLDKRARRKVKYElvgdgKEYVGF 156

                        170       180       190
                 ....*....|....*....|....*....|.
gi 157817282 189 EIPDVFVVGYALDYNEYFRDLNHICVINEHG 219
Cdd:PLN02238 157 ECPDEFVVGYGLDFAEKYRNLPYVGVLKPEV 187
PTZ00271 PTZ00271
hypoxanthine-guanine phosphoribosyltransferase; Provisional
 69-222 1.06e-21

hypoxanthine-guanine phosphoribosyltransferase; Provisional


Pssm-ID: 140297  Cd Length: 211  Bit Score: 88.93  E-value: 1.06e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817282  69 ILVLCVLKGGYKFCADLVEHLknisrnSDRFVSMKVDFIRLKSYKND-RSMGEMQIIGgEDLSTLAGKNVLIVEDVVGTG 147
Cdd:PTZ00271  59 LYLLCVLKGSFIFTADLARFL------ADEGVPVKVEFICASSYGTGvETSGQVRMLL-DVRDSVENRHILIVEDIVDSA 131

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157817282 148 RTMEALLSSIEKYKPNMVKVASLLVKRTARSDSFRPDYAGFEIPDVFVVGYALDYNEYFRDLNHICVINEHGKEK 222
Cdd:PTZ00271 132 ITLQYLMRFMLAKKPASLKTVVLLDKPSGRKVEVLVDYPVITIPHAFVIGYGMDYAESYRELRDICVLKKEYYEK 206
Hpt1 COG2236
Hypoxanthine phosphoribosyltransferase [Coenzyme transport and metabolism]; Hypoxanthine ...
 49-195 5.21e-21

Hypoxanthine phosphoribosyltransferase [Coenzyme transport and metabolism]; Hypoxanthine phosphoribosyltransferase is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 441837 [Multi-domain]  Cd Length: 153  Bit Score: 85.28  E-value: 5.21e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817282  49 IVDRIERLAKDIMKDiGYHDILVLCVLKGGYkFCADLVEHLKNISRnsdrfvsmkVDFIRLKSYKNDRSMGEMQIIGGED 128
Cdd:COG2236   14 IHELSRRLAEQILES-GFRPDVIVAIARGGL-VPARILADALGVPD---------LASIRVSSYTGTAKRLEEPVVKGPL 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 157817282 129 LSTLAGKNVLIVEDVVGTGRTMEALLSSIEKYKPNMVKVASLLVKRTARsdsFRPDYAGFEIPDVFV 195
Cdd:COG2236   83 DEDLAGKRVLIVDDVADTGRTLEAVRDLLKEAGPAEVRTAVLYYKPSSK---FKPDYYAEETDAWIV 146
PRK09162 PRK09162
hypoxanthine-guanine phosphoribosyltransferase; Provisional
 33-212 2.19e-20

hypoxanthine-guanine phosphoribosyltransferase; Provisional


Pssm-ID: 181675  Cd Length: 181  Bit Score: 84.53  E-value: 2.19e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817282  33 QHYYGDLECvLIPHGIIVDRIERLAKDIMKDIGYHDILVLCVLKGGYKFCADLVEHLknisrnsdRFvSMKVDFIRLKSY 112
Cdd:PRK09162   7 RQVLAEADC-LVSAAEVEAAIDRMADEITADLADENPLVLCVMGGGLVFTGQLLPRL--------DF-PLEFDYLHATRY 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817282 113 KNDRSMGEMQIIGGEDLStLAGKNVLIVEDVVGTGRTMEALLSSIEKYKPNMVKVASLLVKRTARSDS-FRPDYAGFEIP 191
Cdd:PRK09162  77 RNETTGGELVWKVKPRES-LKGRTVLVVDDILDEGHTLAAIRDRCLEMGAAEVYSAVLVDKTHDRKAKpLKADFVGLEVP 155

                        170       180
                 ....*....|....*....|.
gi 157817282 192 DVFVVGYALDYNEYFRDLNHI 212
Cdd:PRK09162 156 DRYVFGYGMDYKGYWRNLPGI 176
Pribosyltran pfam00156
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl ...
 46-203 9.39e-19

Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1. Amidophosphoribosyltransferase EC:2.4.2.14. Orotate phosphoribosyl-transferase EC:2.4.2.10. Uracil phosphoribosyl-transferase EC:2.4.2.9. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain.


Pssm-ID: 425489 [Multi-domain]  Cd Length: 150  Bit Score: 79.33  E-value: 9.39e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817282   46 HGIIVDRIERLAKDIMKDIGYHDILVLCVLKGGYKFCADLVEHLKNisrnsdrfvsmKVDFIRLKSYkNDRSMGEMQIIg 125
Cdd:pfam00156   8 NPAILKAVARLAAQINEDYGGKPDVVVGILRGGLPFAGILARRLDV-----------PLAFVRKVSY-NPDTSEVMKTS- 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157817282  126 gEDLSTLAGKNVLIVEDVVGTGRTMEALLSSIEKYKPNMVKVASLLVKRTARSDSFRPDYAGFEiPDVFVVGYALDYN 203
Cdd:pfam00156  75 -SALPDLKGKTVLIVDDILDTGGTLLKVLELLKNVGPKEVKIAVLIDKPAGTEPKDKYDKRVDD-WIVFVVGFGLDER 150
PRK15423 PRK15423
hypoxanthine phosphoribosyltransferase; Provisional
 42-212 3.72e-18

hypoxanthine phosphoribosyltransferase; Provisional


Pssm-ID: 185321  Cd Length: 178  Bit Score: 78.52  E-value: 3.72e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817282  42 VLIPHGIIVDRIERLAKDI---MKDIGyHDILVLCVLKGGYKFCADLVEHLKnisrnsdrfVSMKVDFIRLKSYKNDRSM 118
Cdd:PRK15423   7 VMIPEAEIKARIAELGRQIterYKDSG-SDMVLVGLLRGSFMFMADLCREVQ---------VSHEVDFMTASSYGSGMST 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817282 119 G-EMQIIGGEDlSTLAGKNVLIVEDVVGTGRTMEALLSSIEKYKPNMVKVASLLVKRTARSDSFRPDYAGFEIPDVFVVG 197
Cdd:PRK15423  77 TrDVKILKDLD-EDIRGKDVLIVEDIIDSGNTLSKVREILSLREPKSLAICTLLDKPSRREVNVPVEFIGFSIPDEFVVG 155

                        170
                 ....*....|....*
gi 157817282 198 YALDYNEYFRDLNHI 212
Cdd:PRK15423 156 YGIDYAQRYRHLPYI 170
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 53-189 1.52e-17

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 75.51  E-value: 1.52e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817282  53 IERLAKDIMKDIGyHDILVLCVLKGGYKFCADLVEHLKnisrnsdrfvsMKVDFIRLKSYKNDRSMGEMQIIGGEDLSTL 132
Cdd:cd06223    2 GRLLAEEIREDLL-EPDVVVGILRGGLPLAAALARALG-----------LPLAFIRKERKGPGRTPSEPYGLELPLGGDV 69

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157817282 133 AGKNVLIVEDVVGTGRTMEALLSSIEKYKPNMVKVASLLVKRTAR----SDSFRPDYAGFE 189
Cdd:cd06223   70 KGKRVLLVDDVIATGGTLLAAIELLKEAGAKVVGVAVLLDKPEGGarelASPGDPVYSLFT 130
PRK07322 PRK07322
adenine phosphoribosyltransferase; Provisional
 118-171 2.20e-05

adenine phosphoribosyltransferase; Provisional


Pssm-ID: 180928  Cd Length: 178  Bit Score: 43.43  E-value: 2.20e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 157817282 118 MGEMQII--GGEDLSTLAGKNVLIVEDVVGTGRTMEALLSSIEKYKPNMVKVASLL 171
Cdd:PRK07322 102 TGKPQLLvlDGADAEKLKGKRVAIVDDVVSTGGTLTALERLVERAGGQVVAKAAIF 157
PRK08558 PRK08558
adenine phosphoribosyltransferase; Provisional
 133-185 9.75e-04

adenine phosphoribosyltransferase; Provisional


Pssm-ID: 181466 [Multi-domain]  Cd Length: 238  Bit Score: 39.20  E-value: 9.75e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 157817282 133 AGKNVLIVEDVVGTGRTMEALLSSIEKYKPNMVKVASLLVKRTARSDSFRPDY 185
Cdd:PRK08558 175 KGDRVLIVDDIIRSGETQRALLDLARQAGADVVGVFFLIAVGEVGIDRAREET 227
PRK05205 PRK05205
bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR;
134-191 6.68e-03

bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR;


Pssm-ID: 235365  Cd Length: 176  Bit Score: 36.26  E-value: 6.68e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 157817282 134 GKNVLIVEDVVGTGRT----MEALLSsiekY-KPNMVKVAsLLVKRTARSDSFRPDYAGFEIP 191
Cdd:PRK05205  95 GKRVILVDDVLYTGRTiraaLDALFD----YgRPARVQLA-VLVDRGHRELPIRADYVGKNIP 152
Apt COG0503
Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein [Nucleotide ...
 133-159 8.99e-03

Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein [Nucleotide transport and metabolism]; Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 440269  Cd Length: 171  Bit Score: 35.82  E-value: 8.99e-03
                         10        20
                 ....*....|....*....|....*..
gi 157817282 133 AGKNVLIVEDVVGTGRTMEALLSSIEK 159
Cdd:COG0503  111 PGDRVLIVDDLLATGGTAKAAIKLVEE 137
PRK02277 PRK02277
orotate phosphoribosyltransferase-like protein; Provisional
 130-174 9.65e-03

orotate phosphoribosyltransferase-like protein; Provisional


Pssm-ID: 235023 [Multi-domain]  Cd Length: 200  Bit Score: 36.00  E-value: 9.65e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 157817282 130 STLAGKNVLIVEDVVGTGRTMEALLSSIEKYKPNMVKVASLLVKR 174
Cdd:PRK02277 136 ASVEGKRCVIVDDVITSGTTMKETIEYLKEHGGKPVAVVVLIDKS 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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