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Conserved domains on  [gi|256773264|ref|NP_001100|]
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disintegrin and metalloproteinase domain-containing protein 8 isoform 1 precursor [Homo sapiens]

Protein Classification

disintegrin and metalloproteinase domain-containing protein( domain architecture ID 12023311)

disintegrin and metalloproteinase domain-containing protein, also called metalloproteinase-disintegrin (ADAM), is a membrane-spanning multi-domain protein which may serve as an integrin ligand

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Reprolysin pfam01421
Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that ...
 200-400 1.07e-102

Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as Swiss:P78325, and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.


:

Pssm-ID: 426256 [Multi-domain]  Cd Length: 200  Bit Score: 315.39  E-value: 1.07e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264  200 RYVELYVVVDNAEFQMLGS-EAAVRHRVLEVVNHVDKLYQKLNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQ 278
Cdd:pfam01421   1 KYIELFIVVDKQLFQKMGSdTTVVRQRVFQVVNLVNSIYKELNIRVVLVGLEIWTDEDKIDVSGDANDTLRNFLKWRQEY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264  279 RTRRHLHDNVQLITGVDFTGTTVGFARVSAMCS-HSSGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQerf 357
Cdd:pfam01421  81 LKKRKPHDVAQLLSGVEFGGTTVGAAYVGGMCSlEYSGGVNEDHSKNLESFAVTMAHELGHNLGMQHDDFNGGCKCP--- 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 256773264  358 EAGRCIMAGSIGSSFPRMFSDCSQAYLESFLERPQSVCLANAP 400
Cdd:pfam01421 158 PGGGCIMNPSAGSSFPRKFSNCSQEDFEQFLTKQKGACLFNKP 200
Pep_M12B_propep pfam01562
Reprolysin family propeptide; This region is the propeptide for members of peptidase family ...
 30-155 1.30e-44

Reprolysin family propeptide; This region is the propeptide for members of peptidase family M12B. The propeptide contains a sequence motif similar to the "cysteine switch" of the matrixins. This motif is found at the C terminus of the alignment but is not well aligned.


:

Pssm-ID: 460254  Cd Length: 128  Bit Score: 156.71  E-value: 1.30e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264   30 EVVLPWRLPGPRVRRALPSHlGLHPERVSYVLGATGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPRGQDHCFYQG 109
Cdd:pfam01562   1 EVVIPVRLDPSRRRRSLASE-STYLDTLSYRLAAFGKKFHLHLTPNRLLLAPGFTVTYYLDGGTGVESPPVQTDHCYYQG 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 256773264  110 HVEGYPDSAASLSTCAGLRGFFQVGSDLHLIEPLDEGG--EGGR-HAVY 155
Cdd:pfam01562  80 HVEGHPDSSVALSTCSGLRGFIRTENEEYLIEPLEKYSreEGGHpHVVY 128
DISIN smart00050
Homologues of snake disintegrins; Snake disintegrins inhibit the binding of ligands to ...
 417-491 4.96e-36

Homologues of snake disintegrins; Snake disintegrins inhibit the binding of ligands to integrin receptors. They contain a 'RGD' sequence, identical to the recognition site of many adhesion proteins. Molecules containing both disintegrin and metalloprotease domains are known as ADAMs.


:

Pssm-ID: 214490  Cd Length: 75  Bit Score: 130.50  E-value: 4.96e-36
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 256773264   417 ERGEQCDCGPPEDCRNRCCNSTTCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDMCDLEEFCDGRHPECPEDAF 491
Cdd:smart00050   1 EEGEECDCGSPKECTDPCCDPATCKLKPGAQCASGPCCDNCKFKPAGTLCRPSVDECDLPEYCNGTSADCPPDPY 75
ACR smart00608
ADAM Cysteine-Rich Domain;
494-605 3.98e-30

ADAM Cysteine-Rich Domain;


:

Pssm-ID: 214743  Cd Length: 137  Bit Score: 115.92  E-value: 3.98e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264   494 NGTPCSG--GYCYNGACPTLAQQCQAFWGPGGQAAEESCFSYDILPG-----C--KASRY-----RADMCGVLQCKGGQQ 559
Cdd:smart00608   2 DGTPCDNgqGYCYNGRCPTRDNQCQALFGPGAKVAPDSCYEELNTKGdrfgnCgrENGTYipcapEDVKCGKLQCTNVSE 81

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 256773264   560 P--LGRAICIV------DVCHALTTEDGTAYEP--VPEGTRCGPEKVCWKGRCQDL 605
Cdd:smart00608  82 LplLGEHATVIysniggLVCWSLDYHLGTDPDIgmVKDGTKCGPGKVCINGQCVDV 137
PHA03378 super family cl33729
EBNA-3B; Provisional
 706-824 2.09e-07

EBNA-3B; Provisional


The actual alignment was detected with superfamily member PHA03378:

Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 54.69  E-value: 2.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 706 AASRVP--AKGGAPAPSRGPQELVPTTHPGQPARHPASSVALKRPPPAPPvTVSSPPFPVPVYTR---QAPKQVIKPTFA 780
Cdd:PHA03378 682 NTMLPIqwAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAP-GRARPPAAAPGRARppaAAPGRARPPAAA 760

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 256773264 781 P-PVPPVKPGAGAANPGPaegavgPKVALKPPIQRKQGAGAPTAP 824
Cdd:PHA03378 761 PgRARPPAAAPGAPTPQP------PPQAPPAPQQRPRGAPTPQPP 799
 
Name Accession Description Interval E-value
Reprolysin pfam01421
Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that ...
 200-400 1.07e-102

Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as Swiss:P78325, and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.


Pssm-ID: 426256 [Multi-domain]  Cd Length: 200  Bit Score: 315.39  E-value: 1.07e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264  200 RYVELYVVVDNAEFQMLGS-EAAVRHRVLEVVNHVDKLYQKLNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQ 278
Cdd:pfam01421   1 KYIELFIVVDKQLFQKMGSdTTVVRQRVFQVVNLVNSIYKELNIRVVLVGLEIWTDEDKIDVSGDANDTLRNFLKWRQEY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264  279 RTRRHLHDNVQLITGVDFTGTTVGFARVSAMCS-HSSGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQerf 357
Cdd:pfam01421  81 LKKRKPHDVAQLLSGVEFGGTTVGAAYVGGMCSlEYSGGVNEDHSKNLESFAVTMAHELGHNLGMQHDDFNGGCKCP--- 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 256773264  358 EAGRCIMAGSIGSSFPRMFSDCSQAYLESFLERPQSVCLANAP 400
Cdd:pfam01421 158 PGGGCIMNPSAGSSFPRKFSNCSQEDFEQFLTKQKGACLFNKP 200
ZnMc_adamalysin_II_like cd04269
Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom ...
 200-398 6.43e-84

Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions.


Pssm-ID: 239797 [Multi-domain]  Cd Length: 194  Bit Score: 266.02  E-value: 6.43e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 200 RYVELYVVVDNAEFQMLGS-EAAVRHRVLEVVNHVDKLYQKLNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQ 278
Cdd:cd04269    1 KYVELVVVVDNSLYKKYGSnLSKVRQRVIEIVNIVDSIYRPLNIRVVLVGLEIWTDKDKISVSGDAGETLNRFLDWKRSN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 279 RTRRHLHDNVQLITGVDFTGTTVGFARVSAMCS-HSSGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENvqGCRCQErf 357
Cdd:cd04269   81 LLPRKPHDNAQLLTGRDFDGNTVGLAYVGGMCSpKYSGGVVQDHSRNLLLFAVTMAHELGHNLGMEHDDG--GCTCGR-- 156

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 256773264 358 eaGRCIMAGSIgSSFPRMFSDCSQAYLESFLERPQSVCLAN 398
Cdd:cd04269  157 --STCIMAPSP-SSLTDAFSNCSYEDYQKFLSRGGGQCLLN 194
Pep_M12B_propep pfam01562
Reprolysin family propeptide; This region is the propeptide for members of peptidase family ...
 30-155 1.30e-44

Reprolysin family propeptide; This region is the propeptide for members of peptidase family M12B. The propeptide contains a sequence motif similar to the "cysteine switch" of the matrixins. This motif is found at the C terminus of the alignment but is not well aligned.


Pssm-ID: 460254  Cd Length: 128  Bit Score: 156.71  E-value: 1.30e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264   30 EVVLPWRLPGPRVRRALPSHlGLHPERVSYVLGATGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPRGQDHCFYQG 109
Cdd:pfam01562   1 EVVIPVRLDPSRRRRSLASE-STYLDTLSYRLAAFGKKFHLHLTPNRLLLAPGFTVTYYLDGGTGVESPPVQTDHCYYQG 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 256773264  110 HVEGYPDSAASLSTCAGLRGFFQVGSDLHLIEPLDEGG--EGGR-HAVY 155
Cdd:pfam01562  80 HVEGHPDSSVALSTCSGLRGFIRTENEEYLIEPLEKYSreEGGHpHVVY 128
DISIN smart00050
Homologues of snake disintegrins; Snake disintegrins inhibit the binding of ligands to ...
 417-491 4.96e-36

Homologues of snake disintegrins; Snake disintegrins inhibit the binding of ligands to integrin receptors. They contain a 'RGD' sequence, identical to the recognition site of many adhesion proteins. Molecules containing both disintegrin and metalloprotease domains are known as ADAMs.


Pssm-ID: 214490  Cd Length: 75  Bit Score: 130.50  E-value: 4.96e-36
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 256773264   417 ERGEQCDCGPPEDCRNRCCNSTTCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDMCDLEEFCDGRHPECPEDAF 491
Cdd:smart00050   1 EEGEECDCGSPKECTDPCCDPATCKLKPGAQCASGPCCDNCKFKPAGTLCRPSVDECDLPEYCNGTSADCPPDPY 75
Disintegrin pfam00200
Disintegrin;
417-489 5.29e-33

Disintegrin;


Pssm-ID: 459709  Cd Length: 74  Bit Score: 121.58  E-value: 5.29e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 256773264  417 ERGEQCDCGPPEDCR-NRCCNSTTCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDMCDLEEFCDGRHPECPED 489
Cdd:pfam00200   1 EEGEECDCGSLEECTnDPCCDAKTCKLKPGAQCSSGPCCTNCQFKPAGTVCRPSKDECDLPEYCNGTSAECPPD 74
ACR smart00608
ADAM Cysteine-Rich Domain;
494-605 3.98e-30

ADAM Cysteine-Rich Domain;


Pssm-ID: 214743  Cd Length: 137  Bit Score: 115.92  E-value: 3.98e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264   494 NGTPCSG--GYCYNGACPTLAQQCQAFWGPGGQAAEESCFSYDILPG-----C--KASRY-----RADMCGVLQCKGGQQ 559
Cdd:smart00608   2 DGTPCDNgqGYCYNGRCPTRDNQCQALFGPGAKVAPDSCYEELNTKGdrfgnCgrENGTYipcapEDVKCGKLQCTNVSE 81

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 256773264   560 P--LGRAICIV------DVCHALTTEDGTAYEP--VPEGTRCGPEKVCWKGRCQDL 605
Cdd:smart00608  82 LplLGEHATVIysniggLVCWSLDYHLGTDPDIgmVKDGTKCGPGKVCINGQCVDV 137
ADAM_CR pfam08516
ADAM cysteine-rich; ADAMs are membrane-anchored proteases that proteolytically modify cell ...
 494-559 1.86e-13

ADAM cysteine-rich; ADAMs are membrane-anchored proteases that proteolytically modify cell surface and extracellular matrix (ECM) in order to alter cell behaviour. It has been shown that the cysteine-rich domain of ADAM13 regulates the protein's metalloprotease activity.


Pssm-ID: 462504  Cd Length: 105  Bit Score: 66.87  E-value: 1.86e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264  494 NGTPC--SGGYCYNGACPTLAQQCQAFWGPGGQAAEESCFSY-----DILPGC--KASRYRA----D-MCGVLQCKGGQQ 559
Cdd:pfam08516   1 DGTPCnnGQAYCYNGRCRDRDQQCQELFGKGAKSAPDACYEEvnskgDRFGNCgrTNGGYVKcekrDvLCGKLQCTNVKE 80
PHA03378 PHA03378
EBNA-3B; Provisional
 706-824 2.09e-07

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 54.69  E-value: 2.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 706 AASRVP--AKGGAPAPSRGPQELVPTTHPGQPARHPASSVALKRPPPAPPvTVSSPPFPVPVYTR---QAPKQVIKPTFA 780
Cdd:PHA03378 682 NTMLPIqwAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAP-GRARPPAAAPGRARppaAAPGRARPPAAA 760

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 256773264 781 P-PVPPVKPGAGAANPGPaegavgPKVALKPPIQRKQGAGAPTAP 824
Cdd:PHA03378 761 PgRARPPAAAPGAPTPQP------PPQAPPAPQQRPRGAPTPQPP 799
half-pint TIGR01645
poly-U binding splicing factor, half-pint family; The proteins represented by this model ...
 690-823 6.25e-04

poly-U binding splicing factor, half-pint family; The proteins represented by this model contain three RNA recognition motifs (rrm: pfam00076) and have been characterized as poly-pyrimidine tract binding proteins associated with RNA splicing factors. In the case of PUF60 (GP|6176532), in complex with p54, and in the presence of U2AF, facilitates association of U2 snRNP with pre-mRNA.


Pssm-ID: 130706 [Multi-domain]  Cd Length: 612  Bit Score: 43.14  E-value: 6.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264  690 VAPKTTMGRSNPLFHQAASRVPAKGGAPA---PSRGPQELVPTTHPGQPARHPASsvALKRPPPAPPvtvssPPFPVPVY 766
Cdd:TIGR01645 318 VAGAAVLGPRAQSPATPSSSLPTDIGNKAvvsSAKKEAEEVPPLPQAAPAVVKPG--PMEIPTPVPP-----PGLAIPSL 390

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264  767 TrqAPKQVIKPTFAPP---VPPVKPGAGAANPgPAEGAVGPKVALKPPIQRKQGAGAPTA 823
Cdd:TIGR01645 391 V--APPGLVAPTEINPsflASPRKKMKREKLP-VTFGALDDTLAWKEPSKEDQTSEDGKM 447
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 705-821 8.73e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.22  E-value: 8.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264  705 QAASRVPAKGgapAPSRGPQELVPTTHPGQPARHPASSVAL----------KRPPPAPPVTVSSPPFPVPVYTRQAPKQV 774
Cdd:pfam03154 193 QAATAGPTPS---APSVPPQGSPATSQPPNQTQSTAAPHTLiqqtptlhpqRLPSPHPPLQPMTQPPPPSQVSPQPLPQP 269

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 256773264  775 IKPTFAPPVP------------PVKPGAGAANPGPAEGAVGPKVALKPPIQRKQGAGAP 821
Cdd:pfam03154 270 SLHGQMPPMPhslqtgpshmqhPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTP 328
 
Name Accession Description Interval E-value
Reprolysin pfam01421
Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that ...
 200-400 1.07e-102

Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as Swiss:P78325, and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.


Pssm-ID: 426256 [Multi-domain]  Cd Length: 200  Bit Score: 315.39  E-value: 1.07e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264  200 RYVELYVVVDNAEFQMLGS-EAAVRHRVLEVVNHVDKLYQKLNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQ 278
Cdd:pfam01421   1 KYIELFIVVDKQLFQKMGSdTTVVRQRVFQVVNLVNSIYKELNIRVVLVGLEIWTDEDKIDVSGDANDTLRNFLKWRQEY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264  279 RTRRHLHDNVQLITGVDFTGTTVGFARVSAMCS-HSSGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQerf 357
Cdd:pfam01421  81 LKKRKPHDVAQLLSGVEFGGTTVGAAYVGGMCSlEYSGGVNEDHSKNLESFAVTMAHELGHNLGMQHDDFNGGCKCP--- 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 256773264  358 EAGRCIMAGSIGSSFPRMFSDCSQAYLESFLERPQSVCLANAP 400
Cdd:pfam01421 158 PGGGCIMNPSAGSSFPRKFSNCSQEDFEQFLTKQKGACLFNKP 200
ZnMc_adamalysin_II_like cd04269
Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom ...
 200-398 6.43e-84

Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions.


Pssm-ID: 239797 [Multi-domain]  Cd Length: 194  Bit Score: 266.02  E-value: 6.43e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 200 RYVELYVVVDNAEFQMLGS-EAAVRHRVLEVVNHVDKLYQKLNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQ 278
Cdd:cd04269    1 KYVELVVVVDNSLYKKYGSnLSKVRQRVIEIVNIVDSIYRPLNIRVVLVGLEIWTDKDKISVSGDAGETLNRFLDWKRSN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 279 RTRRHLHDNVQLITGVDFTGTTVGFARVSAMCS-HSSGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENvqGCRCQErf 357
Cdd:cd04269   81 LLPRKPHDNAQLLTGRDFDGNTVGLAYVGGMCSpKYSGGVVQDHSRNLLLFAVTMAHELGHNLGMEHDDG--GCTCGR-- 156

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 256773264 358 eaGRCIMAGSIgSSFPRMFSDCSQAYLESFLERPQSVCLAN 398
Cdd:cd04269  157 --STCIMAPSP-SSLTDAFSNCSYEDYQKFLSRGGGQCLLN 194
Pep_M12B_propep pfam01562
Reprolysin family propeptide; This region is the propeptide for members of peptidase family ...
 30-155 1.30e-44

Reprolysin family propeptide; This region is the propeptide for members of peptidase family M12B. The propeptide contains a sequence motif similar to the "cysteine switch" of the matrixins. This motif is found at the C terminus of the alignment but is not well aligned.


Pssm-ID: 460254  Cd Length: 128  Bit Score: 156.71  E-value: 1.30e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264   30 EVVLPWRLPGPRVRRALPSHlGLHPERVSYVLGATGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPRGQDHCFYQG 109
Cdd:pfam01562   1 EVVIPVRLDPSRRRRSLASE-STYLDTLSYRLAAFGKKFHLHLTPNRLLLAPGFTVTYYLDGGTGVESPPVQTDHCYYQG 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 256773264  110 HVEGYPDSAASLSTCAGLRGFFQVGSDLHLIEPLDEGG--EGGR-HAVY 155
Cdd:pfam01562  80 HVEGHPDSSVALSTCSGLRGFIRTENEEYLIEPLEKYSreEGGHpHVVY 128
ZnMc_ADAM_like cd04267
Zinc-dependent metalloprotease, ADAM_like or reprolysin_like subgroup. The adamalysin_like or ...
 200-389 5.14e-39

Zinc-dependent metalloprotease, ADAM_like or reprolysin_like subgroup. The adamalysin_like or ADAM family of metalloproteases contains proteolytic domains from snake venoms, proteases from the mammalian reproductive tract, and the tumor necrosis factor alpha convertase, TACE. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions.


Pssm-ID: 239795  Cd Length: 192  Bit Score: 143.33  E-value: 5.14e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 200 RYVELYVVVDNAEF-QMLGSEAAVRHRVLEVVNHVDKLYQK----LNFRVVLVGLEIWNSQDRFHV-SPDPSVTLENLLT 273
Cdd:cd04267    1 REIELVVVADHRMVsYFNSDENILQAYITELINIANSIYRStnlrLGIRISLEGLQILKGEQFAPPiDSDASNTLNSFSF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 274 WQARQRTRrhlHDNVQLITGVDFT-GTTVGFARVSAMC-SHSSGAVNQDHSKNPVgVACTMAHEMGHNLGMDHDENvqGC 351
Cdd:cd04267   81 WRAEGPIR---HDNAVLLTAQDFIeGDILGLAYVGSMCnPYSSVGVVEDTGFTLL-TALTMAHELGHNLGAEHDGG--DE 154

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 256773264 352 RCQERFEAGRCIMAGSIGSSFPRMFSDCSQAYLESFLE 389
Cdd:cd04267  155 LAFECDGGGNYIMAPVDSGLNSYRFSQCSIGSIREFLD 192
ZnMc_ADAMTS_like cd04273
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) ...
 200-396 8.86e-39

Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix.


Pssm-ID: 239801  Cd Length: 207  Bit Score: 143.15  E-value: 8.86e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 200 RYVELYVVVDNAEFQMLGSEAaVRHRVLEVVNHVDKLYQK----LNFRVVLVGLEIW-NSQDRFHVSPDPSVTLENLLTW 274
Cdd:cd04273    1 RYVETLVVADSKMVEFHHGED-LEHYILTLMNIVASLYKDpslgNSINIVVVRLIVLeDEESGLLISGNAQKSLKSFCRW 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 275 QARQRTRR----HLHDNVQLITGVDF-----TGTTVGFARVSAMCS-HSSGAVNQDhskNPVGVACTMAHEMGHNLGMDH 344
Cdd:cd04273   80 QKKLNPPNdsdpEHHDHAILLTRQDIcrsngNCDTLGLAPVGGMCSpSRSCSINED---TGLSSAFTIAHELGHVLGMPH 156

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 256773264 345 DENvqGCRCQERFEAGrCIMAGSIGS-SFPRMFSDCSQAYLESFLERPQSVCL 396
Cdd:cd04273  157 DGD--GNSCGPEGKDG-HIMSPTLGAnTGPFTWSKCSRRYLTSFLDTGDGNCL 206
DISIN smart00050
Homologues of snake disintegrins; Snake disintegrins inhibit the binding of ligands to ...
 417-491 4.96e-36

Homologues of snake disintegrins; Snake disintegrins inhibit the binding of ligands to integrin receptors. They contain a 'RGD' sequence, identical to the recognition site of many adhesion proteins. Molecules containing both disintegrin and metalloprotease domains are known as ADAMs.


Pssm-ID: 214490  Cd Length: 75  Bit Score: 130.50  E-value: 4.96e-36
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 256773264   417 ERGEQCDCGPPEDCRNRCCNSTTCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDMCDLEEFCDGRHPECPEDAF 491
Cdd:smart00050   1 EEGEECDCGSPKECTDPCCDPATCKLKPGAQCASGPCCDNCKFKPAGTLCRPSVDECDLPEYCNGTSADCPPDPY 75
Disintegrin pfam00200
Disintegrin;
417-489 5.29e-33

Disintegrin;


Pssm-ID: 459709  Cd Length: 74  Bit Score: 121.58  E-value: 5.29e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 256773264  417 ERGEQCDCGPPEDCR-NRCCNSTTCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDMCDLEEFCDGRHPECPED 489
Cdd:pfam00200   1 EEGEECDCGSLEECTnDPCCDAKTCKLKPGAQCSSGPCCTNCQFKPAGTVCRPSKDECDLPEYCNGTSAECPPD 74
ACR smart00608
ADAM Cysteine-Rich Domain;
494-605 3.98e-30

ADAM Cysteine-Rich Domain;


Pssm-ID: 214743  Cd Length: 137  Bit Score: 115.92  E-value: 3.98e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264   494 NGTPCSG--GYCYNGACPTLAQQCQAFWGPGGQAAEESCFSYDILPG-----C--KASRY-----RADMCGVLQCKGGQQ 559
Cdd:smart00608   2 DGTPCDNgqGYCYNGRCPTRDNQCQALFGPGAKVAPDSCYEELNTKGdrfgnCgrENGTYipcapEDVKCGKLQCTNVSE 81

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 256773264   560 P--LGRAICIV------DVCHALTTEDGTAYEP--VPEGTRCGPEKVCWKGRCQDL 605
Cdd:smart00608  82 LplLGEHATVIysniggLVCWSLDYHLGTDPDIgmVKDGTKCGPGKVCINGQCVDV 137
ZnMc cd00203
Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major ...
 200-388 2.83e-17

Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which are involved in vertebrate development and disease.


Pssm-ID: 238124 [Multi-domain]  Cd Length: 167  Bit Score: 79.87  E-value: 2.83e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 200 RYVELYVVVDNAEFqmlgSEAAVRHRVLEVVNHVDKLY-QKLNFRVVLVGLEIWNsqdrfhvspdpsvtlenlltwqarq 278
Cdd:cd00203    1 KVIPYVVVADDRDV----EEENLSAQIQSLILIAMQIWrDYLNIRFVLVGVEIDK------------------------- 51

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 279 rtrrhlHDNVQLITGVDFTGTTVGFARVSAMC-SHSSGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQERF 357
Cdd:cd00203   52 ------ADIAILVTRQDFDGGTGGWAYLGRVCdSLRGVGVLQDNQSGTKEGAQTIAHELGHALGFYHDHDRKDRDDYPTI 125

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 256773264 358 E--------AGRCIM---AGSIGSSFPRMFSDCSQAYLESFL 388
Cdd:cd00203  126 DdtlnaeddDYYSVMsytKGSFSDGQRKDFSQCDIDQINKLY 167
Reprolysin_5 pfam13688
Metallo-peptidase family M12;
199-377 1.01e-16

Metallo-peptidase family M12;


Pssm-ID: 372673  Cd Length: 191  Bit Score: 79.00  E-value: 1.01e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264  199 TRYVELYVVVDNAEFQMLGSEAAVRhRVLEVVNHVDKLYQK-LNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLT--WQ 275
Cdd:pfam13688   2 TRTVALLVAADCSYVAAFGGDAAQA-NIINMVNTASNVYERdFNISLGLVNLTISDSTCPYTPPACSTGDSSDRLSefQD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264  276 ARQRTRRHLHDNVQLITGVDFTGTtvGFARVSAMCSH-SSGAVNQDHSKNPVGVAC-----TMAHEMGHNLGMDHD---- 345
Cdd:pfam13688  81 FSAWRGTQNDDLAYLFLMTNCSGG--GLAWLGQLCNSgSAGSVSTRVSGNNVVVSTatewqVFAHEIGHNFGAVHDcdss 158

                         170       180       190
                  ....*....|....*....|....*....|....
gi 256773264  346 ENVQGCRCQERFEA--GRCIMAGSIGSSFpRMFS 377
Cdd:pfam13688 159 TSSQCCPPSNSTCPagGRYIMNPSSSPNS-TDFS 191
ZnMc_salivary_gland_MPs cd04272
Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary ...
 201-396 1.07e-16

Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary glands of arthropods.


Pssm-ID: 239800  Cd Length: 220  Bit Score: 79.70  E-value: 1.07e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 201 YVELYVVVDNAEFQMLGSEAAVRHRVLEVVNHVDKLYQKLN---FRVVLVGLEI----WNSQDRFHVSP---DPSVTLEN 270
Cdd:cd04272    2 YPELFVVVDYDHQSEFFSNEQLIRYLAVMVNAANLRYRDLKsprIRLLLVGITIskdpDFEPYIHPINYgyiDAAETLEN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 271 LLTwQARQRTRRHLHDNVQLITGVDFTGT--------TVGFARVSAMCSHSSGAVNQDHSKNPVGVAcTMAHEMGHNLGM 342
Cdd:cd04272   82 FNE-YVKKKRDYFNPDVVFLVTGLDMSTYsggslqtgTGGYAYVGGACTENRVAMGEDTPGSYYGVY-TMTHELAHLLGA 159

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 256773264 343 DHDENVQGCRCQERFEAGRC------IMagSIGSSFPRM--FSDCSQAYLESFLERPQSVCL 396
Cdd:cd04272  160 PHDGSPPPSWVKGHPGSLDCpwddgyIM--SYVVNGERQyrFSQCSQRQIRNVFRRLGASCL 219
Reprolysin_3 pfam13582
Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the ...
 225-345 1.17e-15

Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the characteriztic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.


Pssm-ID: 463926 [Multi-domain]  Cd Length: 122  Bit Score: 73.94  E-value: 1.17e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264  225 RVLEVVNHVDKLYQK-LNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQaRQRTRRHLHDNVQLITGVDFTGTTvGF 303
Cdd:pfam13582   2 RIVSLVNRANTIYERdLGIRLQLAAIIITTSADTPYTSSDALEILDELQEVN-DTRIGQYGYDLGHLFTGRDGGGGG-GI 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 256773264  304 ARVSAMCSHSSGA-VNQDHSKNPVGVACTMAHEMGHNLGMDHD 345
Cdd:pfam13582  80 AYVGGVCNSGSKFgVNSGSGPVGDTGADTFAHEIGHNFGLNHT 122
ADAM_CR pfam08516
ADAM cysteine-rich; ADAMs are membrane-anchored proteases that proteolytically modify cell ...
 494-559 1.86e-13

ADAM cysteine-rich; ADAMs are membrane-anchored proteases that proteolytically modify cell surface and extracellular matrix (ECM) in order to alter cell behaviour. It has been shown that the cysteine-rich domain of ADAM13 regulates the protein's metalloprotease activity.


Pssm-ID: 462504  Cd Length: 105  Bit Score: 66.87  E-value: 1.86e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264  494 NGTPC--SGGYCYNGACPTLAQQCQAFWGPGGQAAEESCFSY-----DILPGC--KASRYRA----D-MCGVLQCKGGQQ 559
Cdd:pfam08516   1 DGTPCnnGQAYCYNGRCRDRDQQCQELFGKGAKSAPDACYEEvnskgDRFGNCgrTNGGYVKcekrDvLCGKLQCTNVKE 80
Reprolysin_4 pfam13583
Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the ...
 200-383 1.69e-10

Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the characteriztic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.


Pssm-ID: 404471  Cd Length: 203  Bit Score: 61.48  E-value: 1.69e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264  200 RYVELYVVVDNAEFQMLGSEAAVRHRVLEVVNHVDKLYQK-LNFRVVLVGLEIWNSQDRfhvSPDPSVTL---ENLLTW- 274
Cdd:pfam13583   3 RVYRVAVATDCTYSASFGSVDELRANINATVTTANEVYGRdFNVSLALISDRDVIYTDS---STDSFNADcsgGDLGNWr 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264  275 QARQRTRRHL--HDNVQLITGVDFTGTTVGFARVSAMCSHSSgavnQDHSKNpvGVAC------TMAHEMGHNLGMDHDE 346
Cdd:pfam13583  80 LATLTSWRDSlnYDLAYLTLMTGPSGQNVGVAWVGALCSSAR----QNAKAS--GVARsrdewdIFAHEIGHTFGAVHDC 153

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 256773264  347 NVQGCRCQERFEAGR--CIMA-GSIGS----SFPRM----FSDCSQAY 383
Cdd:pfam13583 154 SSQGEGLSSSTEDGSgqTIMSyASTASqtafSPCTIrninGNPCSQAN 201
Reprolysin_2 pfam13574
Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the ...
 220-380 3.11e-09

Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the characteriztic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.


Pssm-ID: 372637  Cd Length: 193  Bit Score: 57.25  E-value: 3.11e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264  220 AAVRHRVLEVVNHVDKLY--QKLNFRVVLVG----LEIWNSQD----RFHVSPDPSVTLENLLTWQARQRtrrhlHDNVQ 289
Cdd:pfam13574   1 GNVTENLVNVVNRVNQIYepDDININGGLVNpgeiPATTSASDsgnnYCNSPTTIVRRLNFLSQWRGEQD-----YCLAH 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264  290 LITGVDFTGTTVGFARVSAMCSHSSGAVnqdhsKNPVGVACT---------------MAHEMGHNLGMDHDENVQG--CR 352
Cdd:pfam13574  76 LVTMGTFSGGELGLAYVGQICQKGASSP-----KTNTGLSTTtnygsfnyptqewdvVAHEVGHNFGATHDCDGSQyaSS 150

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 256773264  353 CQERFEA-------GRCIMAGSiGSSFPRMFSDCS 380
Cdd:pfam13574 151 GCERNAAtsvcsanGSFIMNPA-SKSNNDLFSPCS 184
PHA03378 PHA03378
EBNA-3B; Provisional
 706-824 2.09e-07

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 54.69  E-value: 2.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 706 AASRVP--AKGGAPAPSRGPQELVPTTHPGQPARHPASSVALKRPPPAPPvTVSSPPFPVPVYTR---QAPKQVIKPTFA 780
Cdd:PHA03378 682 NTMLPIqwAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAP-GRARPPAAAPGRARppaAAPGRARPPAAA 760

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 256773264 781 P-PVPPVKPGAGAANPGPaegavgPKVALKPPIQRKQGAGAPTAP 824
Cdd:PHA03378 761 PgRARPPAAAPGAPTPQP------PPQAPPAPQQRPRGAPTPQPP 799
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 714-824 3.75e-07

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 53.56  E-value: 3.75e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 714 GGAPAPSRGPQELVPTTHPGQPARHPASSVALKRPPPAPPVTVSSPPFPVPVytRQAPKQVIKPTFAPPVPPVKPGAGAA 793
Cdd:PRK14951 368 AAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPA--AAPPAPVAAPAAAAPAAAPAAAPAAV 445

                         90       100       110
                 ....*....|....*....|....*....|.
gi 256773264 794 NPGPAEGAVGPKVALKPPIQRKQGAGAPTAP 824
Cdd:PRK14951 446 ALAPAPPAQAAPETVAIPVRVAPEPAVASAA 476
PHA03247 PHA03247
large tegument protein UL36; Provisional
 692-824 1.16e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.63  E-value: 1.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264  692 PKTTMGRSNPLFHQAASRVPAKGGAPAPSRGPQELVPTTHPGQPARHP--ASSVALKRPPPAPPVTVSSPPFPVPvyTRQ 769
Cdd:PHA03247 2643 PPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPtvGSLTSLADPPPPPPTPEPAPHALVS--ATP 2720

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 256773264  770 APKQVIKPTFAPPVPPVKPgagaANPGPAEGAVGPKVALKPPI-QRKQGAGAPTAP 824
Cdd:PHA03247 2721 LPPGPAAARQASPALPAAP----APPAVPAGPATPGGPARPARpPTTAGPPAPAPP 2772
ZnMc_ADAM_fungal cd04271
Zinc-dependent metalloprotease, ADAM_fungal subgroup. The adamalysin_like or ADAM (A ...
 217-390 1.36e-06

Zinc-dependent metalloprotease, ADAM_fungal subgroup. The adamalysin_like or ADAM (A Disintegrin And Metalloprotease) family of metalloproteases are integral membrane proteases acting on a variety of extracellular targets. They are involved in shedding soluble peptides or proteins from the cell surface. This subfamily contains fungal ADAMs, whose precise function has yet to be determined.


Pssm-ID: 239799 [Multi-domain]  Cd Length: 228  Bit Score: 50.11  E-value: 1.36e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 217 GSEAAVRHRVLEVVNHVDKLYQK-LNFRVVLVGLEIWNSQD--------RFHVSPDPSVTLENLLTWQARQRTRRHLHDN 287
Cdd:cd04271   18 GSVEEARRNILNNVNSASQLYESsFNISLGLRNLTISDASCpstavdsaPWNLPCNSRIDIDDRLSIFSQWRGQQPDDGN 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 288 V--QLITGVDfTGTTVGFARVSAMC--SHSSGAVNQDHSKNPVGVACT----MAHEMGHNLGMDHDENVQGCRcQERFEA 359
Cdd:cd04271   98 AfwTLMTACP-SGSEVGVAWLGQLCrtGASDQGNETVAGTNVVVRTSNewqvFAHEIGHTFGAVHDCTSGTCS-DGSVGS 175

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 256773264 360 GRC--------------IMAGSIGSSFPRmFSDCSQAYLESFLER 390
Cdd:cd04271  176 QQCcplststcdangqyIMNPSSSSGITE-FSPCTIGNICSLLGR 219
PHA03247 PHA03247
large tegument protein UL36; Provisional
 687-814 3.26e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.09  E-value: 3.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264  687 SRNVAPKTTMGRSNPlfhqAASRVPAKGGAPAPSRGPQELVPTTHPGQPARHPASSVALKRPPPAPPVTVS---SPPFPV 763
Cdd:PHA03247 2755 ARPARPPTTAGPPAP----APPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAaspAGPLPP 2830

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 256773264  764 PVYTRQAPKQVIKPTFAPPVPP---VKPGAGAANPGPAEGAVG-PKVALKPPIQR 814
Cdd:PHA03247 2831 PTSAQPTAPPPPPGPPPPSLPLggsVAPGGDVRRRPPSRSPAAkPAAPARPPVRR 2885
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 706-823 5.72e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 49.98  E-value: 5.72e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 706 AASRVPAKGGAPAPSRGPQELVPTTHPGQPARHPASSVALKRPPPAPPVTVSSPPFPVPVYTRQAPKQVIKPTfAPPVPP 785
Cdd:PRK07764 395 AAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPA-PAPAAA 473

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 256773264 786 VKPGAGAANPGPAEGAvgPKVALKPPIQRKQGAGAPTA 823
Cdd:PRK07764 474 PEPTAAPAPAPPAAPA--PAAAPAAPAAPAAPAGADDA 509
ZnMc_TACE_like cd04270
Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha ...
 204-380 7.13e-06

Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.


Pssm-ID: 239798 [Multi-domain]  Cd Length: 244  Bit Score: 48.14  E-value: 7.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 204 LYVVVDNAEFQMLGS--EAAVRHRVLEVVNHVDKLYQKLNFRVVL---VGLEIwnSQDRFHVSPDPSVTLENLLT----- 273
Cdd:cd04270    5 LLLVADHRFYKYMGRgeEETTINYLISHIDRVDDIYRNTDWDGGGfkgIGFQI--KRIRIHTTPDEVDPGNKFYNksfpn 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 274 -----WQARQRTRRHLHDN--VQLITGVDFTGTTVGFARVSAMCSHSSGAVNQDHSKNPVGVA----------------- 329
Cdd:cd04270   83 wgvekFLVKLLLEQFSDDVclAHLFTYRDFDMGTLGLAYVGSPRDNSAGGICEKAYYYSNGKKkylntgltttvnygkrv 162

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 330 ------CTMAHEMGHNLGMDHDENVQGCRCQERfEAGRCIM-AGSIGSSFP--RMFSDCS 380
Cdd:cd04270  163 ptkesdLVTAHELGHNFGSPHDPDIAECAPGES-QGGNYIMyARATSGDKEnnKKFSPCS 221
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 705-796 7.24e-06

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 49.42  E-value: 7.24e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 705 QAASRVPAKGGaPAPSRGPQELVPTTHPGQParhPASSVALKRPPPAPPVT--VSSPPFPVPVYTRQAPKQVIKPTFAPP 782
Cdd:PRK14950 372 TAAAPSPVRPT-PAPSTRPKAAAAANIPPKE---PVRETATPPPVPPRPVAppVPHTPESAPKLTRAAIPVDEKPKYTPP 447

                         90
                 ....*....|....
gi 256773264 783 VPPVKPGAGAANPG 796
Cdd:PRK14950 448 APPKEEEKALIADG 461
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 681-810 1.88e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 48.17  E-value: 1.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 681 ARSRILSRNVAPKTTMGRSNPLFHQAASRVPAKGGAPAPSRGPQE-LVPTTHPGQPArhpASSVALKRPPPAPPVTVSSP 759
Cdd:PRK14951 353 ALTMVLLRLLAFKPAAAAEAAAPAEKKTPARPEAAAPAAAPVAQAaAAPAPAAAPAA---AASAPAAPPAAAPPAPVAAP 429

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 256773264 760 PFPVPVYTRQAPKQVIKPTFAPPVPP----------VKPGAGAANPGPAEGAVGPKVALKP 810
Cdd:PRK14951 430 AAAAPAAAPAAAPAAVALAPAPPAQAapetvaipvrVAPEPAVASAAPAPAAAPAAARLTP 490
PHA03247 PHA03247
large tegument protein UL36; Provisional
 707-824 2.85e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.01  E-value: 2.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264  707 ASRVPAKGGAPAPSRGPQELVPTTHPGQPARHPASSVA-----LKRPPP-APPVTVSSPPFP-VPVYTRQAPKQVIKPTF 779
Cdd:PHA03247 2820 PAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVApggdvRRRPPSrSPAAKPAAPARPpVRRLARPAVSRSTESFA 2899

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 256773264  780 APPVPPVKPGAGAANPGPAEGAVGPKVALKPPIQRKQG-AGAPTAP 824
Cdd:PHA03247 2900 LPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPrPQPPLAP 2945
PHA03247 PHA03247
large tegument protein UL36; Provisional
 692-824 4.69e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.24  E-value: 4.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264  692 PKTTMGRSNPLFHQAASRV-PAKGGAPAPSRGPQELVPTTHPGQPARHPASSVALKRPPPAPPVTVSSPPFPVPVytrQA 770
Cdd:PHA03247 2713 HALVSATPLPPGPAAARQAsPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPA---VA 2789

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 256773264  771 PKQVIKPTFAPPVPPVKPGAGAANPGPAEGAVGPKVALKPPIQRKQGAGAPTAP 824
Cdd:PHA03247 2790 SLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPP 2843
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 510-602 5.16e-05

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


Pssm-ID: 465496  Cd Length: 68  Bit Score: 41.95  E-value: 5.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264  510 TLAQQCQAFWGPGGQaaeeSCFSYDilpgckasryrADMCGVLQCKGGQQPlgraicivdVCHalttedgTAYEPVPEGT 589
Cdd:pfam17771   6 SADEQCRLIFGPGST----FCPNGD-----------EDVCSKLWCSNPGGS---------TCT-------TKNLPAADGT 54

                          90
                  ....*....|...
gi 256773264  590 RCGPEKVCWKGRC 602
Cdd:pfam17771  55 PCGNKKWCLNGKC 67
PHA03247 PHA03247
large tegument protein UL36; Provisional
 690-821 5.84e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.24  E-value: 5.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264  690 VAPKTTMGRSNPLFHQAASRVPakgGAPAPSRGPQE---LVPTTHPGQPAR--------HPASSVALKRPPPAPPVTVSS 758
Cdd:PHA03247 2837 TAPPPPPGPPPPSLPLGGSVAP---GGDVRRRPPSRspaAKPAAPARPPVRrlarpavsRSTESFALPPDQPERPPQPQA 2913

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 256773264  759 PPFPVPVYTRQAPKQvikPTFAPPVPPVKPGAGAANPGPAeGAVGPKVALKPPiqrKQGAGAP 821
Cdd:PHA03247 2914 PPPPQPQPQPPPPPQ---PQPPPPPPPRPQPPLAPTTDPA-GAGEPSGAVPQP---WLGALVP 2969
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 707-818 6.19e-05

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 46.10  E-value: 6.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 707 ASRVPAKGGAPAPSRGPQELVPTTHPGQPARHPASSVALKRPPPAPPVTVSSPP---FPVPVYTRQAP-KQVIKP--TFA 780
Cdd:PTZ00436 239 AAAAPAKAAAAPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPakaAAAPAKAAAAPaKAAAAPakAAA 318

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 256773264 781 PPVPPVKPGAGAANPgPAEGAVGPKVALKPPIQRKQGA 818
Cdd:PTZ00436 319 PPAKAAAPPAKAATP-PAKAAAPPAKAAAAPVGKKAGG 355
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
685-824 7.38e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 46.41  E-value: 7.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 685 ILSRN---VAPKTTMGRSNPLFHQAASRVPAKGGAPAPSRGPQELVPTTHPGQPARHPASSVALKRPPPAPPVTVSSPPF 761
Cdd:PRK12323 337 NLGRSelaLAPDEYAGFTMTLLRMLAFRPGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAA 416

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 256773264 762 PVPVYTRQAPKQVIKPTFAPPVPPVKPGAGAANPGPAEGAVgPKVALKPPIQRKQGAGAPTAP 824
Cdd:PRK12323 417 RAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAA-PAAAARPAAAGPRPVAAAAAA 478
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 706-824 9.33e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 45.96  E-value: 9.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 706 AASRVPAKGGAPAPSRGPQElvPTTHPGQPARHPASSvalkRPPPAPPVTVSSPPFPVPVytrqapkqvikPTFAPPVPP 785
Cdd:PRK14950 361 VPVPAPQPAKPTAAAPSPVR--PTPAPSTRPKAAAAA----NIPPKEPVRETATPPPVPP-----------RPVAPPVPH 423

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 256773264 786 VKPgagAANPGPAEGA-VGPKVALKPPIQRKQGAGAPTAP 824
Cdd:PRK14950 424 TPE---SAPKLTRAAIpVDEKPKYTPPAPPKEEEKALIAD 460
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
707-823 1.02e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 46.02  E-value: 1.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 707 ASRVPAKGGAPAPS-RGPQELVPTTHPGQPARHPASSVALKRPPPAPPVTVSSPPFPVPVYTRQAPKQVIKPTFAPPVPP 785
Cdd:PRK12323 375 ATAAAAPVAQPAPAaAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAP 454

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 256773264 786 VKPGAGAANPgPAEGAVGPKVALKPPIQRKQGAGAPTA 823
Cdd:PRK12323 455 AAAPAAAARP-AAAGPRPVAAAAAAAPARAAPAAAPAP 491
PHA03247 PHA03247
large tegument protein UL36; Provisional
 690-824 1.58e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 1.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264  690 VAPKTTMGRSNPlfHQAASRVPAKGGAPAPSRGPQELVPttHPGQPARHPASSVALKRPPPAPPVTVSSPPFPVPVYTRQ 769
Cdd:PHA03247 2856 VAPGGDVRRRPP--SRSPAAKPAAPARPPVRRLARPAVS--RSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQP 2931

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264  770 APKQVIKPTfaPPVPPVKPGAGA-----ANPGPAEGAVGPKVALKPPIQRKQGAGAPTAP 824
Cdd:PHA03247 2932 PPPPPPRPQ--PPLAPTTDPAGAgepsgAVPQPWLGALVPGRVAVPRFRVPQPAPSREAP 2989
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 706-824 1.63e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 45.36  E-value: 1.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 706 AASRVPAKGGAPAPSRGPQElvPTTHPGQPARHPASSVALKRPPPAPPVTVSSPPFPVPVYTRQAPKQVIKPTFAPPVPP 785
Cdd:PRK07764 616 AAPAAPAAPAAPAPAGAAAA--PAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAP 693

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 256773264 786 VKPGAGAANPGPAEGAVGPKVALKPPIQRKQGAGAPTAP 824
Cdd:PRK07764 694 AGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPS 732
PHA03247 PHA03247
large tegument protein UL36; Provisional
 685-822 1.83e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 1.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264  685 ILSRNVAPKTTMGRSNPLFHQAASRVPAKGGAPAPSRGPQELVPTTHPGQPARH-------PASSVALKRPP----PAPP 753
Cdd:PHA03247 2811 VLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRrppsrspAAKPAAPARPPvrrlARPA 2890

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 256773264  754 VTVSSPPFPVPVYTRQAPKQvikPTFAPPVPPVKPGAGAANPGPAEGAVGPKVALKPPIQRKQGAGAPT 822
Cdd:PHA03247 2891 VSRSTESFALPPDQPERPPQ---PQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPS 2956
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
711-824 2.05e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 44.84  E-value: 2.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 711 PAKGGAPAPSRGPQELVPTTHPGQPARHPASSVALKRPP-PAPPVTVSSPPFPVPVYTRQAPKQVIKPTFAPPVP----- 784
Cdd:PRK07003 360 PAVTGGGAPGGGVPARVAGAVPAPGARAAAAVGASAVPAvTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPAtadrg 439

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 256773264 785 ------PVKPGAGAANPGPAEGAVGPKVALKPPIQRKQGAGAPTAP 824
Cdd:PRK07003 440 ddaadgDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAP 485
PHA03247 PHA03247
large tegument protein UL36; Provisional
 687-824 2.18e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 2.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264  687 SRNVAPKTTMGRSNPlfhqAASRVPAKGGAPAPSRGPQELVPTTHPGQPARHPASSVALKRPPPAPPVTVSSPPFPVPVY 766
Cdd:PHA03247 2728 ARQASPALPAAPAPP----AVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWD 2803

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 256773264  767 TRQAPKQVIK-----------------PTFAPPVPPVKPGAGAANPGPAEGAVGP--KVALKPPIQrkQGAGAPTAP 824
Cdd:PHA03247 2804 PADPPAAVLApaaalppaaspagplppPTSAQPTAPPPPPGPPPPSLPLGGSVAPggDVRRRPPSR--SPAAKPAAP 2878
PHA03247 PHA03247
large tegument protein UL36; Provisional
 679-824 2.46e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 2.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264  679 RKARSRILSRNVAPKTTMGRSNPLFHQAASR----VPAKGGAPAPSRGPQELVPTTH---PGQPARHPASSVAlKRPPPA 751
Cdd:PHA03247 2681 QRPRRRAARPTVGSLTSLADPPPPPPTPEPAphalVSATPLPPGPAAARQASPALPAapaPPAVPAGPATPGG-PARPAR 2759

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264  752 PPVTvSSPPFPVPVYTRQAPkqvikPTFAPPVPPVKPGAGAAN-------PGPAEGAVGPKVALKPPIQRKQG------A 818
Cdd:PHA03247 2760 PPTT-AGPPAPAPPAAPAAG-----PPRRLTRPAVASLSESREslpspwdPADPPAAVLAPAAALPPAASPAGplppptS 2833


                  ....*.
gi 256773264  819 GAPTAP 824
Cdd:PHA03247 2834 AQPTAP 2839
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
705-824 2.59e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 44.48  E-value: 2.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 705 QAASRVPAKGGAPAPSRGPQELVPTTHPGQPARHPASSVALKRPPPAPPVTVSSPPFPVPVYTRQAPKQVIKPTFAPP-- 782
Cdd:PRK12323 421 AAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPwe 500

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 256773264 783 -------VPPVKPGAGAANPGPAEGAVGPKVALKPPIQRKQGAGAPTAP 824
Cdd:PRK12323 501 elppefaSPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAP 549
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 705-802 2.79e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 44.59  E-value: 2.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 705 QAASRVPAKGGAPAPSRGPQELVPTTHPGQPARHPASSVALKRPPPAPPVTVSSPPFPVPVytrqapkqvikPTFAPPVP 784
Cdd:PRK07764 425 PAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPP-----------AAPAPAAA 493

                         90
                 ....*....|....*...
gi 256773264 785 PVKPGAGAANPGPAEGAV 802
Cdd:PRK07764 494 PAAPAAPAAPAGADDAAT 511
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 703-810 2.89e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 44.47  E-value: 2.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 703 FHQAASrVPAKGGAPAPSRGPQELVPTTHPGQPARHPASSVALKRPPPAPPVTVSSPPFPVPVYTRQAPKQVIKPTFAPP 782
Cdd:PRK07994 359 FHPAAP-LPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQRAQGATK 437

                         90       100
                 ....*....|....*....|....*...
gi 256773264 783 VPPVKPgAGAANPGPAEGAVGPKVALKP 810
Cdd:PRK07994 438 AKKSEP-AAASRARPVNSALERLASVRP 464
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 703-824 3.45e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 44.21  E-value: 3.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 703 FHQAASRVPAKGGAPAPSRGPQELVPTTHPGQPARHPASSVALKRPPPAPPVTVSSPPFPVPVYTRQAPKQVIKPTFAPP 782
Cdd:PRK07764 374 LLARLERLERRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGA 453

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 256773264 783 VPPVKPGAGAANPGPAEGAVGPKVAlkPPIQRKQGAGAPTAP 824
Cdd:PRK07764 454 PSPPPAAAPSAQPAPAPAAAPEPTA--APAPAPPAAPAPAAA 493
PHA03269 PHA03269
envelope glycoprotein C; Provisional
 681-768 3.87e-04

envelope glycoprotein C; Provisional


Pssm-ID: 165527 [Multi-domain]  Cd Length: 566  Bit Score: 43.95  E-value: 3.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 681 ARSRILSRNVAPKTTMGRS---NPLFHQAASRVPAKGGAP--APSRGPQELVPTThpGQPARHPAS-----SVALKRPPP 750
Cdd:PHA03269  63 AASRKPDLAQAPTPAASEKfdpAPAPHQAASRAPDPAVAPqlAAAPKPDAAEAFT--SAAQAHEAPadagtSAASKKPDP 140

                         90
                 ....*....|....*...
gi 256773264 751 APPVTVSSPPFpvpVYTR 768
Cdd:PHA03269 141 AAHTQHSPPPF---AYTR 155
PHA03378 PHA03378
EBNA-3B; Provisional
 692-824 3.92e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 44.29  E-value: 3.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 692 PKTTMGRSNPLfHQAASRVPAKGGAPAPSRGPQELVPTTHP--GQPARHPASSVALKRPPPAPPVTVssPPFPvpvytRQ 769
Cdd:PHA03378 717 PAAATGRARPP-AAAPGRARPPAAAPGRARPPAAAPGRARPpaAAPGRARPPAAAPGAPTPQPPPQA--PPAP-----QQ 788

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 256773264 770 APKQVIKPTFAPPVPP----VKPGAGAANPGPAEGAVGPKVALKP----PIQRKQGAGAPTAP 824
Cdd:PHA03378 789 RPRGAPTPQPPPQAGPtsmqLMPRAAPGQQGPTKQILRQLLTGGVkrgrPSLKKPAALERQAA 851
PHA03247 PHA03247
large tegument protein UL36; Provisional
 677-824 4.52e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 4.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264  677 VYRKARSRILSRNVAPKTTMGRSNPlfhqAASRvPAKGGAPAPSRGPqelvPTTHPGQPARHPASSvALKRPPPAPPVTV 756
Cdd:PHA03247 2661 VSRPRRARRLGRAAQASSPPQRPRR----RAAR-PTVGSLTSLADPP----PPPPTPEPAPHALVS-ATPLPPGPAAARQ 2730

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264  757 SSPPFPVPVYTRQAPKQVIKPT--FAPPVPPVKPGAGAANPgPAEGAVGPKVALKPPIQRKQGAGAPTAP 824
Cdd:PHA03247 2731 ASPALPAAPAPPAVPAGPATPGgpARPARPPTTAGPPAPAP-PAAPAAGPPRRLTRPAVASLSESRESLP 2799
half-pint TIGR01645
poly-U binding splicing factor, half-pint family; The proteins represented by this model ...
 690-823 6.25e-04

poly-U binding splicing factor, half-pint family; The proteins represented by this model contain three RNA recognition motifs (rrm: pfam00076) and have been characterized as poly-pyrimidine tract binding proteins associated with RNA splicing factors. In the case of PUF60 (GP|6176532), in complex with p54, and in the presence of U2AF, facilitates association of U2 snRNP with pre-mRNA.


Pssm-ID: 130706 [Multi-domain]  Cd Length: 612  Bit Score: 43.14  E-value: 6.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264  690 VAPKTTMGRSNPLFHQAASRVPAKGGAPA---PSRGPQELVPTTHPGQPARHPASsvALKRPPPAPPvtvssPPFPVPVY 766
Cdd:TIGR01645 318 VAGAAVLGPRAQSPATPSSSLPTDIGNKAvvsSAKKEAEEVPPLPQAAPAVVKPG--PMEIPTPVPP-----PGLAIPSL 390

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264  767 TrqAPKQVIKPTFAPP---VPPVKPGAGAANPgPAEGAVGPKVALKPPIQRKQGAGAPTA 823
Cdd:TIGR01645 391 V--APPGLVAPTEINPsflASPRKKMKREKLP-VTFGALDDTLAWKEPSKEDQTSEDGKM 447
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 726-823 6.53e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 43.26  E-value: 6.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 726 LVPTTHPgQPARHPASSVALKRPPPAPpvtvsSPPFPVPVYTRQAPKQVIKPTFAPPVPPVKPGAGAANPGPAEGAVGPK 805
Cdd:PRK14950 360 LVPVPAP-QPAKPTAAAPSPVRPTPAP-----STRPKAAAAANIPPKEPVRETATPPPVPPRPVAPPVPHTPESAPKLTR 433

                         90
                 ....*....|....*...
gi 256773264 806 VALKPPIQRKQGAGAPTA 823
Cdd:PRK14950 434 AAIPVDEKPKYTPPAPPK 451
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 705-821 8.73e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.22  E-value: 8.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264  705 QAASRVPAKGgapAPSRGPQELVPTTHPGQPARHPASSVAL----------KRPPPAPPVTVSSPPFPVPVYTRQAPKQV 774
Cdd:pfam03154 193 QAATAGPTPS---APSVPPQGSPATSQPPNQTQSTAAPHTLiqqtptlhpqRLPSPHPPLQPMTQPPPPSQVSPQPLPQP 269

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 256773264  775 IKPTFAPPVP------------PVKPGAGAANPGPAEGAVGPKVALKPPIQRKQGAGAP 821
Cdd:pfam03154 270 SLHGQMPPMPhslqtgpshmqhPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTP 328
PRK12373 PRK12373
NADH-quinone oxidoreductase subunit E;
684-810 8.93e-04

NADH-quinone oxidoreductase subunit E;


Pssm-ID: 237082 [Multi-domain]  Cd Length: 400  Bit Score: 42.48  E-value: 8.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 684 RILSRNVAPKTTMGRSNPLFHQAASRVPAKGGAPAPSRGPQELVPTTHPGQPARHPASSVALKRPPPAPPVTVSSPPFPV 763
Cdd:PRK12373 185 RYASEPAGGLTSLTEEAGKARYNASKALAEDIGDTVKRIDGTEVPLLAPWQGDAAPVPPSEAARPKSADAETNAALKTPA 264

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 256773264 764 PvytrqAPKQVIKPTFAPPVPPVkPGAGAANPGPAEGAVGPKVALKP 810
Cdd:PRK12373 265 T-----APKAAAKNAKAPEAQPV-SGTAAAEPAPKEAAKAAAAAAKP 305
PRK14954 PRK14954
DNA polymerase III subunits gamma and tau; Provisional
 711-808 1.02e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184918 [Multi-domain]  Cd Length: 620  Bit Score: 42.62  E-value: 1.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 711 PAKGGAPAPSRGPQEL--VPTTHPGQPARHPASsvALKRPPPAPPVTVSSPPfpvpvyTRQAPKQVIKPTFAPPVPPvkp 788
Cdd:PRK14954 376 NDGGVAPSPAGSPDVKkkAPEPDLPQPDRHPGP--AKPEAPGARPAELPSPA------SAPTPEQQPPVARSAPLPP--- 444

                         90       100
                 ....*....|....*....|
gi 256773264 789 gAGAANPGPAEGAVGPKVAL 808
Cdd:PRK14954 445 -SPQASAPRNVASGKPGVDL 463
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 707-824 1.04e-03

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 42.24  E-value: 1.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 707 ASRVPAKGGAPAPSRGPQELVPTTHPGQPARHPASSVALKRPPPAPPVTVSSPPFPVPVYTRQAPKQVIKPTFAPPVPPV 786
Cdd:PTZ00436 225 AAAAPAKAAAPPAKAAAAPAKAAAAPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAAPAKAAA 304

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 256773264 787 KPGAGAANPG-----PAEGAVGPKVALKPPIQRKQG-AGAPTAP 824
Cdd:PTZ00436 305 APAKAAAAPAkaaapPAKAAAPPAKAATPPAKAAAPpAKAAAAP 348
PLN02983 PLN02983
biotin carboxyl carrier protein of acetyl-CoA carboxylase
 744-821 1.06e-03

biotin carboxyl carrier protein of acetyl-CoA carboxylase


Pssm-ID: 215533 [Multi-domain]  Cd Length: 274  Bit Score: 41.75  E-value: 1.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 744 ALKRPPPAPPVTVSSPPFPVPVYTRQAPKQVIKPTFAPPVPPVKPgagaANPGPAEGAVGPKVALKPPIQ----RKQGAG 819
Cdd:PLN02983 140 ALPQPPPPAPVVMMQPPPPHAMPPASPPAAQPAPSAPASSPPPTP----ASPPPAKAPKSSHPPLKSPMAgtfyRSPAPG 215


                 ..
gi 256773264 820 AP 821
Cdd:PLN02983 216 EP 217
PHA03247 PHA03247
large tegument protein UL36; Provisional
 718-821 1.19e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 1.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264  718 APSRGPQELVPTTHPGQPARHPASSVALKRP--PPAP--PVTVSSPPFPVPvytRQAPKQVIKPTFAPPVPPVKPGAGAA 793
Cdd:PHA03247 2559 APPAAPDRSVPPPRPAPRPSEPAVTSRARRPdaPPQSarPRAPVDDRGDPR---GPAPPSPLPPDTHAPDPPPPSPSPAA 2635

                          90       100
                  ....*....|....*....|....*...
gi 256773264  794 NPGPaegavGPKVALKPPIQRKQGAGAP 821
Cdd:PHA03247 2636 NEPD-----PHPPPTVPPPERPRDDPAP 2658
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 706-824 1.56e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.28  E-value: 1.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 706 AASRVPAKGGAPAPSRGPQELVPTTHPGQPARHPASSVALKRPPPAPPVTVSSPPFPVPVYTRQApkQVIKPTFAPPVPP 785
Cdd:PRK07764 604 ASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDG--WPAKAGGAAPAAP 681

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 256773264 786 VKPGAGAANPGPAEGAVG---PKVALKPPIQRKQGAGAPTAP 824
Cdd:PRK07764 682 PPAPAPAAPAAPAGAAPAqpaPAPAATPPAGQADDPAAQPPQ 723
PRK13700 PRK13700
conjugal transfer protein TraD; Provisional
 735-824 1.67e-03

conjugal transfer protein TraD; Provisional


Pssm-ID: 184256 [Multi-domain]  Cd Length: 732  Bit Score: 41.87  E-value: 1.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 735 PARHPASSVALK---RPPPAP---PVTVSSPP---FPVPVYTRQAPKQVIKPTFAPPVPPVKPGAGAANPGPAEGAVGPK 805
Cdd:PRK13700 550 PGPYPAVKLSLKyqaRPKVAPefiPRDINPEMenrLSAVLAAREAEGRQMASLFEPDVPEVASGEDVTQAEQPQQPQQPQ 629

                         90       100
                 ....*....|....*....|....*...
gi 256773264 806 VALKPP---------IQRKQGAGAPTAP 824
Cdd:PRK13700 630 QPQQPQqpqqpvspvINDKKSDAGVNVP 657
PHA03378 PHA03378
EBNA-3B; Provisional
 701-824 1.83e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 41.98  E-value: 1.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 701 PLFHQAASRVPAkgGAPAPSRGPQELV---------PTTHPGQPA-------RHPASSVALKRPPPAPPvTVSSPPFPVP 764
Cdd:PHA03378 635 PLRMQPITFNVL--VFPTPHQPPQVEItpykptwtqIGHIPYQPSptgantmLPIQWAPGTMQPPPRAP-TPMRPPAAPP 711

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 256773264 765 VyTRQAPKQVIKPTFAPPVPPVKPGAGAANPGPAEGAVGPKVALKPPI---------QRKQGAGAPTAP 824
Cdd:PHA03378 712 G-RAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAaapgrarppAAAPGAPTPQPP 779
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 680-824 1.89e-03

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 41.47  E-value: 1.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 680 KARSRILSRNVAPKTTMGRSNPLFHQAASRVPA--KGGAPAPSRGPQELVPTTHPGQPARHPASSVALKRPPP---APPV 754
Cdd:PTZ00436 172 KARKQELRKREKDRERARREDAAAAAAAKQKAAakKAAAPSGKKSAKAAAPAKAAAAPAKAAAPPAKAAAAPAkaaAAPA 251

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 755 TVSSPPFPVPVYTRQAPKQVIKPTfAPPVPPVKPGAGAANPgPAEGAVGPKVALKPPIQRKQGAGAPTAP 824
Cdd:PTZ00436 252 KAAAPPAKAAAPPAKAAAPPAKAA-APPAKAAAPPAKAAAP-PAKAAAAPAKAAAAPAKAAAAPAKAAAP 319
Rib_recp_KP_reg pfam05104
Ribosome receptor lysine/proline rich region; This highly conserved region is found towards ...
 709-778 2.34e-03

Ribosome receptor lysine/proline rich region; This highly conserved region is found towards the C-terminus of the transmembrane domain. The function is unclear.


Pssm-ID: 461548 [Multi-domain]  Cd Length: 140  Bit Score: 38.95  E-value: 2.34e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264  709 RVPAKGGAPAPSRGPQELVPTTHPGQPARHPASSVALKRPPPAPPVTVSSPPFPVPVYTRQAPKQVIKPT 778
Cdd:pfam05104  71 EAPSAALEPEPVPTPVPAPVEPEPAPPSESPAPSPKEKKKKEKKSAKVEPAETPEAVQPKPALEKEEPPA 140
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
690-804 2.34e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.40  E-value: 2.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 690 VAPKTTMGRSNPLFHQAASRVPAKGGAPAPSRGPQELVPTTHPGQPARH--PASSVALKRPPPAPPvtvssppfPVPVYT 767
Cdd:PRK12323 390 AAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQasARGPGGAPAPAPAPA--------AAPAAA 461

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 256773264 768 RQAPKQVIKPTFAPPVPPVKPGAGAANPGPAEGAVGP 804
Cdd:PRK12323 462 ARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPP 498
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 707-793 2.50e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 41.41  E-value: 2.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264  707 ASRVPAKGGAPAPSRGPQELVPTTHPGQPAR----HPASSVALKRPPPAPPVTVSSPPFPVPVYTRQAPKQVIKPTFAPP 782
Cdd:PRK12270   34 ADYGPGSTAAPTAAAAAAAAAASAPAAAPAAkapaAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAAAAPAAAAV 113

                          90
                  ....*....|.
gi 256773264  783 VPPVKPGAGAA 793
Cdd:PRK12270  114 EDEVTPLRGAA 124
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 736-824 2.89e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 41.00  E-value: 2.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 736 ARHPASSVAlkrPPPAPPvtVSSPPFPVPVYTRQAPKQVIKPTFAPPVPPVKPGAGAANPGPAEGAVGPKVALKPPIQRK 815
Cdd:PRK07994 358 AFHPAAPLP---EPEVPP--QSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQRA 432


                 ....*....
gi 256773264 816 QGAGAPTAP 824
Cdd:PRK07994 433 QGATKAKKS 441
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
690-823 4.23e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 40.63  E-value: 4.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 690 VAPKTTMGRSNPLFHQAASRVPAKGGAPAPSRGPQELVPTTHPGQPARHPASSVALKRPPPAPPVTVSSP---PFPVPVY 766
Cdd:PRK12323 396 APAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAAARPAaagPRPVAAA 475

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 256773264 767 TRQAPKQVIKPTFAPPVPPVKP-----GAGAANPGPAEGAVGPKVALKPPIQRKQGAGAPTA 823
Cdd:PRK12323 476 AAAAPARAAPAAAPAPADDDPPpweelPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDA 537
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 705-804 4.71e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 40.47  E-value: 4.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264 705 QAASRVPAKGGAPAPSRGPQELVPTTHPGQPARHPA--SSVALKRPPPAP---PVTVSSPPFPVPVYTRQ--APKQVIKP 777
Cdd:PRK14951 389 PAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPApvAAPAAAAPAAAPaaaPAAVALAPAPPAQAAPEtvAIPVRVAP 468

                         90       100
                 ....*....|....*....|....*..
gi 256773264 778 TFAPPVPPVKPGAGAANPGPAEGAVGP 804
Cdd:PRK14951 469 EPAVASAAPAPAAAPAAARLTPTEEGD 495
FAP pfam07174
Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment ...
 742-824 5.62e-03

Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment proteins (FAP). Family members are rich in alanine and proline, are approximately 300 long, and seem to be restricted to mycobacteria. These proteins contain a fibronectin-binding motif that allows mycobacteria to bind to fibronectin in the extracellular matrix.


Pssm-ID: 429334  Cd Length: 301  Bit Score: 39.52  E-value: 5.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773264  742 SVALKRPPPAPPVTVSSPPFPVPVYTRQAPKQVikptfAPPVPPVKPGAGAANPGPAEgavgPKVALKPPIQRKQGAGAP 821
Cdd:pfam07174  35 AVAHADPEPAPPPPSTATAPPAPPPPPPAPAAP-----APPPPPAAPNAPNAPPPPAD----PNAPPPPPADPNAPPPPA 105


                  ...
gi 256773264  822 TAP 824
Cdd:pfam07174 106 VDP 108
Peptidase_M54 cd11375
Peptidase family M54, also called archaemetzincins or archaelysins; Peptidase M54 ...
 328-367 8.93e-03

Peptidase family M54, also called archaemetzincins or archaelysins; Peptidase M54 (archaemetzincin or archaelysin) is a zinc-dependent aminopeptidase that contains the consensus zinc-binding sequence HEXXHXXGXXH/D and a conserved Met residue at the active site, and is thus classified as a metzincin. Archaemetzincins, first identified in archaea, are also found in bacteria and eukaryotes, including two human members, archaemetzincin-1 and -2 (AMZ1 and AMZ2). AMZ1 is mainly found in the liver and heart while AMZ2 is primarily expressed in testis and heart; both have been reported to degrade synthetic substrates and peptides. The Peptidase M54 family contains an extended metzincin concensus sequence of HEXXHXXGX3CX4CXMX17CXXC such that a second zinc ion is bound to four cysteines, thus resembling a zinc finger. Phylogenetic analysis of this family reveals a complex evolutionary process involving a series of lateral gene transfer, gene loss and genetic duplication events.


Pssm-ID: 213029  Cd Length: 173  Bit Score: 38.05  E-value: 8.93e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 256773264 328 VACTMAHEMGHNLGMDHdenvqgcrCQERfeagRCIMAGS 367
Cdd:cd11375  123 LLKEAVHELGHLFGLDH--------CPYY----ACVMNFS 150
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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