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Conserved domains on  [gi|399220330|ref|NP_001100537|]
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inactive rhomboid protein 2 [Rattus norvegicus]

Protein Classification

inactive rhomboid protein 2( domain architecture ID 13782860)

inactive rhomboid protein 2 (iRhom2) regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Rhomboid_SP pfam12595
Rhomboid serine protease; This domain family is found in eukaryotes, and is approximately 210 ...
 98-280 1.35e-98

Rhomboid serine protease; This domain family is found in eukaryotes, and is approximately 210 amino acids in length. The family is found in association with pfam01694. Rhomboid is a seven-transmembrane spanning protein that resides in the Golgi and acts as a serine protease to cleave Spitz.


:

Pssm-ID: 463639  Cd Length: 193  Bit Score: 304.49  E-value: 1.35e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399220330   98 VSGDWEGKrQNWQRRSLHHCSVHYGRLKASCQRELELPSQEVPSFQGTESPKPCKMPK-------IVDPLARGRAFRHPD 170
Cdd:pfam12595   1 VSKDSDST-QRWQRKSLRHCSMRYGKLKPQVIREMELPSQDNPSLTSTETPPPLYLPKshhgmqrIVDPLARGRAFRMVE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399220330  171 EVDRPHAAHAPLTPGVLSLTSFSSVRSGYSHLP-RRKRISVAHMSFQAAAALLKGRSVLDATGQRCRnvKRSFVYPSFLE 249
Cdd:pfam12595  80 EVDGYSVPQTPITPGVASLCSFTSSRSGLNRLPrRRKRESVAKMSFRAAAALMKGRSLRESTLRRRR--RRSFTPPSFLE 157

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 399220330  250 EDAVDGADTFD-SFFSK----EEMSSMPDDVFESPP 280
Cdd:pfam12595 158 EDTVDFADELDtSFFSKddlhEELSSMADEVFESPS 193
Rhomboid pfam01694
Rhomboid family; This family contains integral membrane proteins that are related to ...
 617-760 2.69e-32

Rhomboid family; This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.


:

Pssm-ID: 426384  Cd Length: 147  Bit Score: 122.33  E-value: 2.69e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399220330  617 PEIPDQFYRIWLSLFLHAGIVHCLVSVVFQMTILRDLEKLAGWHRISIIFILSGITGNLASAIFLPY-RAEVGPAGSQFG 695
Cdd:pfam01694   1 PVQPGQLWRLITSMFLHAGWLHLLFNMLALLFFGGPLERILGSVRFLLLYLLSGIAGSLLSYLFSPLsTPSVGASGAIFG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 399220330  696 LLACLFVELFQSWQLLERPWKAFFNLSAIVLFLFICGLLPW--IDNIAHIFGFLSGMLLAFAFLPYI 760
Cdd:pfam01694  81 LLGALLVLGPRNRILLFGLIGALLALLLFILLNLVLGLLPGngVSNLAHLGGLLVGLLLGFILLRRP 147
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 718-808 7.00e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd06173:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 383  Bit Score: 42.99  E-value: 7.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399220330 718 FFNLSAIVLFLFICGLLpwidnIAHIFG--FLSGMLLAFAFLPYITFGT-----SDRYRKQALILVSLLVFAGLFASLVL 790
Cdd:cd06173    9 LLSALGDWIFTVALPWL-----VLQLTGsaLLVGLVLAAFFLPFLLFSPfagvlADRFDRRRLLILADLLRALLAAVLAL 83

                         90
                 ....*....|....*...
gi 399220330 791 WLYIYPINWPWIeYLTCF 808
Cdd:cd06173   84 LALLGSLSLWLL-LVLAF 100
 
Name Accession Description Interval E-value
Rhomboid_SP pfam12595
Rhomboid serine protease; This domain family is found in eukaryotes, and is approximately 210 ...
 98-280 1.35e-98

Rhomboid serine protease; This domain family is found in eukaryotes, and is approximately 210 amino acids in length. The family is found in association with pfam01694. Rhomboid is a seven-transmembrane spanning protein that resides in the Golgi and acts as a serine protease to cleave Spitz.


Pssm-ID: 463639  Cd Length: 193  Bit Score: 304.49  E-value: 1.35e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399220330   98 VSGDWEGKrQNWQRRSLHHCSVHYGRLKASCQRELELPSQEVPSFQGTESPKPCKMPK-------IVDPLARGRAFRHPD 170
Cdd:pfam12595   1 VSKDSDST-QRWQRKSLRHCSMRYGKLKPQVIREMELPSQDNPSLTSTETPPPLYLPKshhgmqrIVDPLARGRAFRMVE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399220330  171 EVDRPHAAHAPLTPGVLSLTSFSSVRSGYSHLP-RRKRISVAHMSFQAAAALLKGRSVLDATGQRCRnvKRSFVYPSFLE 249
Cdd:pfam12595  80 EVDGYSVPQTPITPGVASLCSFTSSRSGLNRLPrRRKRESVAKMSFRAAAALMKGRSLRESTLRRRR--RRSFTPPSFLE 157

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 399220330  250 EDAVDGADTFD-SFFSK----EEMSSMPDDVFESPP 280
Cdd:pfam12595 158 EDTVDFADELDtSFFSKddlhEELSSMADEVFESPS 193
Rhomboid pfam01694
Rhomboid family; This family contains integral membrane proteins that are related to ...
 617-760 2.69e-32

Rhomboid family; This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.


Pssm-ID: 426384  Cd Length: 147  Bit Score: 122.33  E-value: 2.69e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399220330  617 PEIPDQFYRIWLSLFLHAGIVHCLVSVVFQMTILRDLEKLAGWHRISIIFILSGITGNLASAIFLPY-RAEVGPAGSQFG 695
Cdd:pfam01694   1 PVQPGQLWRLITSMFLHAGWLHLLFNMLALLFFGGPLERILGSVRFLLLYLLSGIAGSLLSYLFSPLsTPSVGASGAIFG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 399220330  696 LLACLFVELFQSWQLLERPWKAFFNLSAIVLFLFICGLLPW--IDNIAHIFGFLSGMLLAFAFLPYI 760
Cdd:pfam01694  81 LLGALLVLGPRNRILLFGLIGALLALLLFILLNLVLGLLPGngVSNLAHLGGLLVGLLLGFILLRRP 147
GlpG COG0705
Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein ...
 622-758 8.96e-20

Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440469 [Multi-domain]  Cd Length: 189  Bit Score: 87.99  E-value: 8.96e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399220330 622 QFYRIWLSLFLHAGIVHclvsVVFQMTIL----RDLEKLAGWHRISIIFILSGITGNLASAIFLPYRAE--VGPAGSQFG 695
Cdd:COG0705   42 ELWRLLTSMFLHGGFLH----LLFNMLALwvfgPLLERRLGSKRFLLLYLLSGLGGGLLQLLFSPGSGYplVGASGAIFG 117

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 399220330 696 LLACLFV-ELFQSWQLLERPWKAFFNLSAIVLFLFICGLLPW--IDNIAHIFGFLSGMLLAFAFLP 758
Cdd:COG0705  118 LLGALLVlGPRRRVLLLFIPIPALLFLLVWLLLGLLFGLLGGggIAWEAHLGGLLAGLLLALLLRK 183
PTZ00101 PTZ00101
rhomboid-1 protease; Provisional
 622-756 1.89e-12

rhomboid-1 protease; Provisional


Pssm-ID: 185445  Cd Length: 278  Bit Score: 68.72  E-value: 1.89e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399220330 622 QFYRIWLSLFLHAGIVHCLVSVVFQMTILRDLEKLAGWHRISIIFILSGITGNL--ASAIFLPYRaeVGPAGSQFGLLAC 699
Cdd:PTZ00101 101 EIHRLILPIFLHANIFHTFFNVFFQLRMGFTLEKNYGIVKIIILYFLTGIYGNIlsSSVTYCPIK--VGASTSGMGLLGI 178

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 399220330 700 LFVELFQSWQLLERPWKAFFNlsaIVLFLFICGLLPW------IDNIAHIFGFLSGMLLAFAF 756
Cdd:PTZ00101 179 VTSELILLWHVIRHRERVVFN---IIFFSLISFFYYFtfngsnIDHVGHLGGLLSGISMGILY 238
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 718-808 7.00e-04

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 42.99  E-value: 7.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399220330 718 FFNLSAIVLFLFICGLLpwidnIAHIFG--FLSGMLLAFAFLPYITFGT-----SDRYRKQALILVSLLVFAGLFASLVL 790
Cdd:cd06173    9 LLSALGDWIFTVALPWL-----VLQLTGsaLLVGLVLAAFFLPFLLFSPfagvlADRFDRRRLLILADLLRALLAAVLAL 83

                         90
                 ....*....|....*...
gi 399220330 791 WLYIYPINWPWIeYLTCF 808
Cdd:cd06173   84 LALLGSLSLWLL-LVLAF 100
SWEET COG4095
Sugar transporter, SemiSWEET family, contains PQ motif [Carbohydrate transport and metabolism]; ...
 743-802 7.49e-03

Sugar transporter, SemiSWEET family, contains PQ motif [Carbohydrate transport and metabolism];


Pssm-ID: 443271  Cd Length: 83  Bit Score: 36.32  E-value: 7.49e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 399220330 743 IFGFLSGMLLAFAFLP-----YITFGTSDryrkqalilVSLLVFAGLFASLVLWLyIYPI---NWPWI 802
Cdd:COG4095    5 IIGLLAGILTTISFLPqviktWKTKSTKD---------ISLGMYLIFTTGVALWL-IYGIligDLPII 62
 
Name Accession Description Interval E-value
Rhomboid_SP pfam12595
Rhomboid serine protease; This domain family is found in eukaryotes, and is approximately 210 ...
 98-280 1.35e-98

Rhomboid serine protease; This domain family is found in eukaryotes, and is approximately 210 amino acids in length. The family is found in association with pfam01694. Rhomboid is a seven-transmembrane spanning protein that resides in the Golgi and acts as a serine protease to cleave Spitz.


Pssm-ID: 463639  Cd Length: 193  Bit Score: 304.49  E-value: 1.35e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399220330   98 VSGDWEGKrQNWQRRSLHHCSVHYGRLKASCQRELELPSQEVPSFQGTESPKPCKMPK-------IVDPLARGRAFRHPD 170
Cdd:pfam12595   1 VSKDSDST-QRWQRKSLRHCSMRYGKLKPQVIREMELPSQDNPSLTSTETPPPLYLPKshhgmqrIVDPLARGRAFRMVE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399220330  171 EVDRPHAAHAPLTPGVLSLTSFSSVRSGYSHLP-RRKRISVAHMSFQAAAALLKGRSVLDATGQRCRnvKRSFVYPSFLE 249
Cdd:pfam12595  80 EVDGYSVPQTPITPGVASLCSFTSSRSGLNRLPrRRKRESVAKMSFRAAAALMKGRSLRESTLRRRR--RRSFTPPSFLE 157

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 399220330  250 EDAVDGADTFD-SFFSK----EEMSSMPDDVFESPP 280
Cdd:pfam12595 158 EDTVDFADELDtSFFSKddlhEELSSMADEVFESPS 193
Rhomboid pfam01694
Rhomboid family; This family contains integral membrane proteins that are related to ...
 617-760 2.69e-32

Rhomboid family; This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.


Pssm-ID: 426384  Cd Length: 147  Bit Score: 122.33  E-value: 2.69e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399220330  617 PEIPDQFYRIWLSLFLHAGIVHCLVSVVFQMTILRDLEKLAGWHRISIIFILSGITGNLASAIFLPY-RAEVGPAGSQFG 695
Cdd:pfam01694   1 PVQPGQLWRLITSMFLHAGWLHLLFNMLALLFFGGPLERILGSVRFLLLYLLSGIAGSLLSYLFSPLsTPSVGASGAIFG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 399220330  696 LLACLFVELFQSWQLLERPWKAFFNLSAIVLFLFICGLLPW--IDNIAHIFGFLSGMLLAFAFLPYI 760
Cdd:pfam01694  81 LLGALLVLGPRNRILLFGLIGALLALLLFILLNLVLGLLPGngVSNLAHLGGLLVGLLLGFILLRRP 147
GlpG COG0705
Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein ...
 622-758 8.96e-20

Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440469 [Multi-domain]  Cd Length: 189  Bit Score: 87.99  E-value: 8.96e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399220330 622 QFYRIWLSLFLHAGIVHclvsVVFQMTIL----RDLEKLAGWHRISIIFILSGITGNLASAIFLPYRAE--VGPAGSQFG 695
Cdd:COG0705   42 ELWRLLTSMFLHGGFLH----LLFNMLALwvfgPLLERRLGSKRFLLLYLLSGLGGGLLQLLFSPGSGYplVGASGAIFG 117

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 399220330 696 LLACLFV-ELFQSWQLLERPWKAFFNLSAIVLFLFICGLLPW--IDNIAHIFGFLSGMLLAFAFLP 758
Cdd:COG0705  118 LLGALLVlGPRRRVLLLFIPIPALLFLLVWLLLGLLFGLLGGggIAWEAHLGGLLAGLLLALLLRK 183
PTZ00101 PTZ00101
rhomboid-1 protease; Provisional
 622-756 1.89e-12

rhomboid-1 protease; Provisional


Pssm-ID: 185445  Cd Length: 278  Bit Score: 68.72  E-value: 1.89e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399220330 622 QFYRIWLSLFLHAGIVHCLVSVVFQMTILRDLEKLAGWHRISIIFILSGITGNL--ASAIFLPYRaeVGPAGSQFGLLAC 699
Cdd:PTZ00101 101 EIHRLILPIFLHANIFHTFFNVFFQLRMGFTLEKNYGIVKIIILYFLTGIYGNIlsSSVTYCPIK--VGASTSGMGLLGI 178

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 399220330 700 LFVELFQSWQLLERPWKAFFNlsaIVLFLFICGLLPW------IDNIAHIFGFLSGMLLAFAF 756
Cdd:PTZ00101 179 VTSELILLWHVIRHRERVVFN---IIFFSLISFFYYFtfngsnIDHVGHLGGLLSGISMGILY 238
MFS_1 pfam07690
Major Facilitator Superfamily;
656-807 5.12e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 43.18  E-value: 5.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399220330  656 LAGWHRISIIFILSGITGNLASAIFL-----PYRAEVGPAGSQFGLLACLFVELFQSWQLLerPWKAFFNLSAIVLFLFI 730
Cdd:pfam07690 144 LASLFGWRAAFLILAILSLLAAVLLLlprppPESKRPKPAEEARLSLIVAWKALLRDPVLW--LLLALLLFGFAFFGLLT 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399220330  731 cgLLPWIDNIAHIFGFLSGMLLAFAFLPYITFG-----TSDRYRKQALILVSLLVFAGLFASLVLWLYIYPINWPWIEYL 805
Cdd:pfam07690 222 --YLPLYQEVLGLSALLAGLLLGLGGLLGAIGRlllgrLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALL 299


                  ..
gi 399220330  806 TC 807
Cdd:pfam07690 300 LL 301
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 718-808 7.00e-04

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 42.99  E-value: 7.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399220330 718 FFNLSAIVLFLFICGLLpwidnIAHIFG--FLSGMLLAFAFLPYITFGT-----SDRYRKQALILVSLLVFAGLFASLVL 790
Cdd:cd06173    9 LLSALGDWIFTVALPWL-----VLQLTGsaLLVGLVLAAFFLPFLLFSPfagvlADRFDRRRLLILADLLRALLAAVLAL 83

                         90
                 ....*....|....*...
gi 399220330 791 WLYIYPINWPWIeYLTCF 808
Cdd:cd06173   84 LALLGSLSLWLL-LVLAF 100
GtrA pfam04138
GtrA-like protein; Members of this family are predicted to be integral membrane proteins with ...
 717-801 1.16e-03

GtrA-like protein; Members of this family are predicted to be integral membrane proteins with three or four transmembrane spans. They are involved in the synthesis of cell surface polysaccharides. The GtrA family are a subset of this family. GtrA is predicted to be an integral membrane protein with 4 transmembrane spans. It is involved is in O antigen modification by Shigella flexneri bacteriophage X (SfX), but does not determine the specificity of glucosylation. Its function remains unknown, but it may play a role in translocation of undecaprenyl phosphate linked glucose (UndP-Glc) across the cytoplasmic membrane. Another member of this family is a DTDP-glucose-4-keto-6-deoxy-D-glucose reductase, which catalyzes the conversion of dTDP-4-keto-6-deoxy-D-glucose to dTDP-D-fucose, which is involved in the biosynthesis of the serotype-specific polysaccharide antigen of Actinobacillus actinomycetemcomitans Y4 (serotype b). This family also includes the teichoic acid glycosylation protein, GtcA, which is a serotype-specific protein in some Listeria innocua and monocytogenes strains. Its exact function is not known, but it is essential for decoration of cell wall teichoic acids with glucose and galactose.


Pssm-ID: 427738  Cd Length: 116  Bit Score: 39.45  E-value: 1.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399220330  717 AFFNLSAIVLFLFICGLLPWIdniAHIFGFLSGMLLAFAFLPYITF-GTSDRYRKQAL--ILVSLLVFAGLFASLVLWLY 793
Cdd:pfam04138  10 TLVDLAVFLLLLELFGLSYLL---ANAIAFVVAILVNFLLNRRWTFrDRRSGSLRELLrfFLVSLAGLLLNLLLLWLLVD 86


                  ....*...
gi 399220330  794 IYPINWPW 801
Cdd:pfam04138  87 GLGLPPLL 94
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
663-808 1.59e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 41.81  E-value: 1.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399220330 663 SIIFILSGITGNLASAIFLPYRAEVGPAGSQ--------FGLLACLFV------------------ELFQSWQLLERPwK 716
Cdd:COG2211  150 SWRFAFAGLGGLLASVLPPPLVAAFGGDAALgyrltaliFAVLGLLAFlltffgtkerpvpeeekvSLKESLKALLKN-R 228

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399220330 717 AFFNLSAIVLFLFICGLLPW----------IDNIAHIFGFLSGMLLAFAFLPYITFGT-SDRYRKQALILVSLLVFAGLF 785
Cdd:COG2211  229 PFLLLLLAYLLFFLALALVAalllyyfkyvLGLSAALVGLLLALYFLAALLGAPLWPRlAKRFGKKKAFIIGLLLAALGL 308

                        170       180
                 ....*....|....*....|...
gi 399220330 786 aslvLWLYIYPINWPWIEYLTCF 808
Cdd:COG2211  309 ----LLLFFLGPGNLWLLLVLAA 327
MreD COG2891
Cell shape-determining protein MreD [Cell wall/membrane/envelope biogenesis];
694-808 4.99e-03

Cell shape-determining protein MreD [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442136  Cd Length: 165  Bit Score: 38.68  E-value: 4.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399220330 694 FGLLACLFVEL--FQSWQLLERPwkaffNLSAIVLfLFICGLLPWIDNIahIFGFLSGML-------------LAFAFLP 758
Cdd:COG2891   14 LSLLLALLLEIlpLPGELLPFRP-----DWLLLVL-VYWSLALPRRVGV--GTAFVLGLLldvlygsllgqhaLALSLVA 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 399220330 759 YITFGTSDRYRKQALILVSLLVFAGLFAS--LVLWLY--IYPINWPWIEYLTCF 808
Cdd:COG2891   86 YLALRLHQRLRNFPLWQQALIVLLLLLLAelLVFWIRllLGGTLPGWSYFLSAL 139
SWEET COG4095
Sugar transporter, SemiSWEET family, contains PQ motif [Carbohydrate transport and metabolism]; ...
 743-802 7.49e-03

Sugar transporter, SemiSWEET family, contains PQ motif [Carbohydrate transport and metabolism];


Pssm-ID: 443271  Cd Length: 83  Bit Score: 36.32  E-value: 7.49e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 399220330 743 IFGFLSGMLLAFAFLP-----YITFGTSDryrkqalilVSLLVFAGLFASLVLWLyIYPI---NWPWI 802
Cdd:COG4095    5 IIGLLAGILTTISFLPqviktWKTKSTKD---------ISLGMYLIFTTGVALWL-IYGIligDLPII 62
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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