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Conserved domains on  [gi|157823389|ref|NP_001100784|]
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probable tRNA methyltransferase 9B [Rattus norvegicus]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10789277)

class I SAM-dependent methyltransferase is an enzyme that uses S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyl transfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:1904047
PubMed:  12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 30-143 6.14e-25

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


:

Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 99.68  E-value: 6.14e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823389  30 KAWPRVRQFLQ--DQKPGSLIADIGCGTGKYLK--VNSQVHTLGCDYCGPLVEIARNR------GCEVMVCDNLNLPFRD 99
Cdd:COG2226    6 ARYDGREALLAalGLRPGARVLDLGCGTGRLALalAERGARVTGVDISPEMLELARERaaeaglNVEFVVGDAEDLPFPD 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 157823389 100 QGFDAIISIGVIHHFSTKQrriRAIKEMARVLAPGGQLMIYVWA 143
Cdd:COG2226   86 GSFDLVISSFVLHHLPDPE---RALAEIARVLKPGGRLVVVDFS 126
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 30-143 6.14e-25

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 99.68  E-value: 6.14e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823389  30 KAWPRVRQFLQ--DQKPGSLIADIGCGTGKYLK--VNSQVHTLGCDYCGPLVEIARNR------GCEVMVCDNLNLPFRD 99
Cdd:COG2226    6 ARYDGREALLAalGLRPGARVLDLGCGTGRLALalAERGARVTGVDISPEMLELARERaaeaglNVEFVVGDAEDLPFPD 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 157823389 100 QGFDAIISIGVIHHFSTKQrriRAIKEMARVLAPGGQLMIYVWA 143
Cdd:COG2226   86 GSFDLVISSFVLHHLPDPE---RALAEIARVLKPGGRLVVVDFS 126
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 48-135 2.92e-23

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 93.40  E-value: 2.92e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823389   48 IADIGCGTGKYL-----KVNSQVHtlGCDYCGPLVEIARNRG------CEVMVCDNLNLPFRDQGFDAIISIGVIHHFST 116
Cdd:pfam13649   1 VLDLGCGTGRLTlalarRGGARVT--GVDLSPEMLERARERAaeaglnVEFVQGDAEDLPFPDGSFDLVVSSGVLHHLPD 78

                          90
                  ....*....|....*....
gi 157823389  117 KQRRiRAIKEMARVLAPGG 135
Cdd:pfam13649  79 PDLE-AALREIARVLKPGG 96
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 9-139 1.33e-16

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 78.66  E-value: 1.33e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823389   9 EKQH-VHKVYESTAP-YfsDLQN--------KAWprvRQFLQDQ---KPGSLIADIGCGTGKYL-----KVNSQVHTLGC 70
Cdd:PRK00216   8 EKQEkVAEMFDSIAPkY--DLMNdllsfglhRVW---RRKTIKWlgvRPGDKVLDLACGTGDLAialakAVGKTGEVVGL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823389  71 DYCGPLVEIARNR--------GCEVMVCDNLNLPFRDQGFDAI-ISIG---VIHhfstkqrRIRAIKEMARVLAPGGQLM 138
Cdd:PRK00216  83 DFSEGMLAVGREKlrdlglsgNVEFVQGDAEALPFPDNSFDAVtIAFGlrnVPD-------IDKALREMYRVLKPGGRLV 155


                 .
gi 157823389 139 I 139
Cdd:PRK00216 156 I 156
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 13-139 6.23e-12

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 64.98  E-value: 6.23e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823389   13 VHKVYESTAPYFSDL-------QNKAWprvRQFLQDQ---KPGSLIADIGCGTG----KYLKVNSQV-HTLGCDYCGPLV 77
Cdd:TIGR01934   1 VQEMFDRIAPKYDLLndllsfgLHRLW---RRRAVKLigvFKGQKVLDVACGTGdlaiELAKSAPDRgKVTGVDFSSEML 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157823389   78 EIARNRGC-----EVMVCDNLNLPFRDQGFDAI-ISIGvIHHFSTKQRrirAIKEMARVLAPGGQLMI 139
Cdd:TIGR01934  78 EVAKKKSElplniEFIQADAEALPFEDNSFDAVtIAFG-LRNVTDIQK---ALREMYRVLKPGGRLVI 141
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 48-139 1.45e-11

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 60.91  E-value: 1.45e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823389  48 IADIGCGTGKY---LKVNSQVHTLGCDYCGPLVEIARNR-------GCEVMVCDNLNLPF-RDQGFDAIISIGVIHHFST 116
Cdd:cd02440    2 VLDLGCGTGALalaLASGPGARVTGVDISPVALELARKAaaalladNVEVLKGDAEELPPeADESFDVIISDPPLHHLVE 81

                         90       100
                 ....*....|....*....|...
gi 157823389 117 KQRRIraIKEMARVLAPGGQLMI 139
Cdd:cd02440   82 DLARF--LEEARRLLKPGGVLVL 102
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 30-143 6.14e-25

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 99.68  E-value: 6.14e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823389  30 KAWPRVRQFLQ--DQKPGSLIADIGCGTGKYLK--VNSQVHTLGCDYCGPLVEIARNR------GCEVMVCDNLNLPFRD 99
Cdd:COG2226    6 ARYDGREALLAalGLRPGARVLDLGCGTGRLALalAERGARVTGVDISPEMLELARERaaeaglNVEFVVGDAEDLPFPD 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 157823389 100 QGFDAIISIGVIHHFSTKQrriRAIKEMARVLAPGGQLMIYVWA 143
Cdd:COG2226   86 GSFDLVISSFVLHHLPDPE---RALAEIARVLKPGGRLVVVDFS 126
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 48-135 2.92e-23

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 93.40  E-value: 2.92e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823389   48 IADIGCGTGKYL-----KVNSQVHtlGCDYCGPLVEIARNRG------CEVMVCDNLNLPFRDQGFDAIISIGVIHHFST 116
Cdd:pfam13649   1 VLDLGCGTGRLTlalarRGGARVT--GVDLSPEMLERARERAaeaglnVEFVQGDAEDLPFPDGSFDLVVSSGVLHHLPD 78

                          90
                  ....*....|....*....
gi 157823389  117 KQRRiRAIKEMARVLAPGG 135
Cdd:pfam13649  79 PDLE-AALREIARVLKPGG 96
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 50-139 5.57e-20

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 84.25  E-value: 5.57e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823389   50 DIGCGTGKYLKVNSQV--HTLGCDYCGPLVEIAR----NRGCEVMVCDNLNLPFRDQGFDAIISIGVIHHFstkQRRIRA 123
Cdd:pfam08241   2 DVGCGTGLLTELLARLgaRVTGVDISPEMLELARekapREGLTFVVGDAEDLPFPDNSFDLVLSSEVLHHV---EDPERA 78

                          90
                  ....*....|....*.
gi 157823389  124 IKEMARVLAPGGQLMI 139
Cdd:pfam08241  79 LREIARVLKPGGILII 94
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 23-152 6.47e-19

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 84.58  E-value: 6.47e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823389  23 YFSDLQNKAWPRVRQFLQDQKPGSLIADIGCGTGKYL-----KVNSQVhtLGCDYCGPLVEIARNR-------GCEVMVC 90
Cdd:COG0500    5 YYSDELLPGLAALLALLERLPKGGRVLDLGCGTGRNLlalaaRFGGRV--IGIDLSPEAIALARARaakaglgNVEFLVA 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 157823389  91 DNLNL-PFRDQGFDAIISIGVIHHFStKQRRIRAIKEMARVLAPGGQLMIYVWAMEQKNRHFE 152
Cdd:COG0500   83 DLAELdPLPAESFDLVVAFGVLHHLP-PEEREALLRELARALKPGGVLLLSASDAAAALSLAR 144
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 30-139 1.09e-18

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 81.60  E-value: 1.09e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823389  30 KAW-PRVRQFLQDQ-KPGSLIADIGCGTGKYLKV----NSQVHtlGCDYCGPLVEIARNR----GCEVMVCDNLNLPFRD 99
Cdd:COG2227    8 DFWdRRLAALLARLlPAGGRVLDVGCGTGRLALAlarrGADVT--GVDISPEALEIARERaaelNVDFVQGDLEDLPLED 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 157823389 100 QGFDAIISIGVIHHFstkQRRIRAIKEMARVLAPGGQLMI 139
Cdd:COG2227   86 GSFDLVICSEVLEHL---PDPAALLRELARLLKPGGLLLL 122
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 9-139 1.33e-16

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 78.66  E-value: 1.33e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823389   9 EKQH-VHKVYESTAP-YfsDLQN--------KAWprvRQFLQDQ---KPGSLIADIGCGTGKYL-----KVNSQVHTLGC 70
Cdd:PRK00216   8 EKQEkVAEMFDSIAPkY--DLMNdllsfglhRVW---RRKTIKWlgvRPGDKVLDLACGTGDLAialakAVGKTGEVVGL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823389  71 DYCGPLVEIARNR--------GCEVMVCDNLNLPFRDQGFDAI-ISIG---VIHhfstkqrRIRAIKEMARVLAPGGQLM 138
Cdd:PRK00216  83 DFSEGMLAVGREKlrdlglsgNVEFVQGDAEALPFPDNSFDAVtIAFGlrnVPD-------IDKALREMYRVLKPGGRLV 155


                 .
gi 157823389 139 I 139
Cdd:PRK00216 156 I 156
PRK08317 PRK08317
hypothetical protein; Provisional
 34-139 2.67e-15

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 74.97  E-value: 2.67e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823389  34 RVRQFLQDQkPGSLIADIGCGTG---KYLK--VNSQVHTLGCDYCGPLVEIARNRGC------EVMVCDNLNLPFRDQGF 102
Cdd:PRK08317  10 RTFELLAVQ-PGDRVLDVGCGPGndaRELArrVGPEGRVVGIDRSEAMLALAKERAAglgpnvEFVRGDADGLPFPDGSF 88

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 157823389 103 DAIISIGVIHHFSTKQRrirAIKEMARVLAPGGQLMI 139
Cdd:PRK08317  89 DAVRSDRVLQHLEDPAR---ALAEIARVLRPGGRVVV 122
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 43-141 2.97e-14

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 69.96  E-value: 2.97e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823389  43 KPGSLIADIGCGTG---KYLKVNSQVHTLGCDYCGPLVEIARNR--------GCEVMVCDNLNLPFrDQGFDAIISIGVI 111
Cdd:COG2230   50 KPGMRVLDIGCGWGglaLYLARRYGVRVTGVTLSPEQLEYARERaaeagladRVEVRLADYRDLPA-DGQFDAIVSIGMF 128

                         90       100       110
                 ....*....|....*....|....*....|
gi 157823389 112 HHFSTKQRRiRAIKEMARVLAPGGQLMIYV 141
Cdd:COG2230  129 EHVGPENYP-AYFAKVARLLKPGGRLLLHT 157
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
12-155 6.89e-14

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 69.64  E-value: 6.89e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823389  12 HVHKVYESTAPYF-----SDLQNKAWPRVRQFLQDQ---KPGSLIADIGCGTG---KYLKvNSQVHTLGCDYCGPLVEIA 80
Cdd:COG4976    6 YVEALFDQYADSYdaalvEDLGYEAPALLAEELLARlppGPFGRVLDLGCGTGllgEALR-PRGYRLTGVDLSEEMLAKA 84

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 157823389  81 RNRGC--EVMVCDNLNLPFRDQGFDAIISIGVIHHFSTKQrriRAIKEMARVLAPGGQLMIYVWAMEQKNRHFEKQD 155
Cdd:COG4976   85 REKGVydRLLVADLADLAEPDGRFDLIVAADVLTYLGDLA---AVFAGVARALKPGGLFIFSVEDADGSGRYAHSLD 158
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
44-141 1.93e-13

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 66.00  E-value: 1.93e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823389  44 PGSLIADIGCGTGKYLKV----NSQVHTLGCDYCGPLVEIARNR--GCEVMVCDNLNLPFrDQGFDAIISIGVIHHFstk 117
Cdd:COG4106    1 PPRRVLDLGCGTGRLTALlaerFPGARVTGVDLSPEMLARARARlpNVRFVVADLRDLDP-PEPFDLVVSNAALHWL--- 76

                         90       100
                 ....*....|....*....|....
gi 157823389 118 QRRIRAIKEMARVLAPGGQLMIYV 141
Cdd:COG4106   77 PDHAALLARLAAALAPGGVLAVQV 100
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 50-137 4.49e-12

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 62.00  E-value: 4.49e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823389   50 DIGCGTG----KYLKVNSQVHTLGCDYCGPLVEIARNR--GCEVMVCDNLNLPFRD------QGFDAIISIGVIHHFSTK 117
Cdd:pfam08242   2 EIGCGTGtllrALLEALPGLEYTGLDISPAALEAARERlaALGLLNAVRVELFQLDlgeldpGSFDVVVASNVLHHLADP 81

                          90       100
                  ....*....|....*....|
gi 157823389  118 QrriRAIKEMARVLAPGGQL 137
Cdd:pfam08242  82 R---AVLRNIRRLLKPGGVL 98
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 13-139 6.23e-12

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 64.98  E-value: 6.23e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823389   13 VHKVYESTAPYFSDL-------QNKAWprvRQFLQDQ---KPGSLIADIGCGTG----KYLKVNSQV-HTLGCDYCGPLV 77
Cdd:TIGR01934   1 VQEMFDRIAPKYDLLndllsfgLHRLW---RRRAVKLigvFKGQKVLDVACGTGdlaiELAKSAPDRgKVTGVDFSSEML 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157823389   78 EIARNRGC-----EVMVCDNLNLPFRDQGFDAI-ISIGvIHHFSTKQRrirAIKEMARVLAPGGQLMI 139
Cdd:TIGR01934  78 EVAKKKSElplniEFIQADAEALPFEDNSFDAVtIAFG-LRNVTDIQK---ALREMYRVLKPGGRLVI 141
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 48-139 1.45e-11

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 60.91  E-value: 1.45e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823389  48 IADIGCGTGKY---LKVNSQVHTLGCDYCGPLVEIARNR-------GCEVMVCDNLNLPF-RDQGFDAIISIGVIHHFST 116
Cdd:cd02440    2 VLDLGCGTGALalaLASGPGARVTGVDISPVALELARKAaaalladNVEVLKGDAEELPPeADESFDVIISDPPLHHLVE 81

                         90       100
                 ....*....|....*....|...
gi 157823389 117 KQRRIraIKEMARVLAPGGQLMI 139
Cdd:cd02440   82 DLARF--LEEARRLLKPGGVLVL 102
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 50-161 5.22e-11

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 60.51  E-value: 5.22e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823389   50 DIGCGTGKYL-----KVNSQVHTLGCDYCGPLVEIARNR-------GCEVMVCDNLNLP--FRDQGFDAIISIGVIHHFS 115
Cdd:pfam13847   9 DLGCGTGHLSfelaeELGPNAEVVGIDISEEAIEKARENaqklgfdNVEFEQGDIEELPelLEDDKFDVVISNCVLNHIP 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 157823389  116 TKQrriRAIKEMARVLAPGGQLMI-YVWAMEQKNRHFEKQDVLVPWN 161
Cdd:pfam13847  89 DPD---KVLQEILRVLKPGGRLIIsDPDSLAELPAHVKEDSTYYAGC 132
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 48-138 3.23e-08

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 54.21  E-value: 3.23e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823389   48 IADIGCGTG----KYLKVNSQVHTLGCDYCGPLVEIARNRGCEVM--VCDNL-NLPFRDQGFDAIISIGVIHHFSTKQrr 120
Cdd:TIGR02072  38 VLDIGCGTGyltrALLKRFPQAEFIALDISAGMLAQAKTKLSENVqfICGDAeKLPLEDSSFDLIVSNLALQWCDDLS-- 115

                          90
                  ....*....|....*...
gi 157823389  121 iRAIKEMARVLAPGGQLM 138
Cdd:TIGR02072 116 -QALSELARVLKPGGLLA 132
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
11-137 5.12e-08

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 53.60  E-value: 5.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823389   11 QHVHKVYESTAPYFsDLQN--------KAWPRVRQFLQDQKPGSLIADIGCGTG----KYLK-VNSQVHTLGCDYCGPLV 77
Cdd:pfam01209   2 QRVGDVFSSVASKY-DLMNdvisfgihRLWKDFTMKCMGVKRGNKFLDVAGGTGdwtfGLSDsAGSSGKVVGLDINENML 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157823389   78 EIARNRGCEV------MVCDN-LNLPFRDQGFDAI-ISIGvIHHFSTKQRrirAIKEMARVLAPGGQL 137
Cdd:pfam01209  81 KEGEKKAKEEgkynieFLQGNaEELPFEDDSFDIVtISFG-LRNFPDYLK---VLKEAFRVLKPGGRV 144
PLN02244 PLN02244
tocopherol O-methyltransferase
 41-168 1.57e-07

tocopherol O-methyltransferase


Pssm-ID: 215135 [Multi-domain]  Cd Length: 340  Bit Score: 52.82  E-value: 1.57e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823389  41 DQKPGSLIADIGCGTG---KYL--KVNSQVH--TLGCDYCGPLVEIARNRG----CEVMVCDNLNLPFRDQGFDAIISIG 109
Cdd:PLN02244 115 DEKRPKRIVDVGCGIGgssRYLarKYGANVKgiTLSPVQAARANALAAAQGlsdkVSFQVADALNQPFEDGQFDLVWSME 194

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823389 110 VIHHFSTKQRrirAIKEMARVLAPGGQLMIYVWAmeqkNRHFEK-QDVLVPWNRALCSRL 168
Cdd:PLN02244 195 SGEHMPDKRK---FVQELARVAAPGGRIIIVTWC----HRDLEPgETSLKPDEQKLLDKI 247
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 36-150 2.20e-07

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 50.50  E-value: 2.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823389   36 RQFLQDQKPGSLIaDIGCGTGKYLKVNSQVhtlGCDYCGplVEIARNRGCEVMVC------DNLNLPFRDQGFDAIISIG 109
Cdd:pfam13489  15 RLLPKLPSPGRVL-DFGCGTGIFLRLLRAQ---GFSVTG--VDPSPIAIERALLNvrfdqfDEQEAAVPAGKFDVIVARE 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 157823389  110 VIHHFstkQRRIRAIKEMARVLAPGGQLMIYVWAMEQKNRH 150
Cdd:pfam13489  89 VLEHV---PDPPALLRQIAALLKPGGLLLLSTPLASDEADR 126
COG4627 COG4627
Predicted SAM-depedendent methyltransferase [General function prediction only];
59-141 4.04e-07

Predicted SAM-depedendent methyltransferase [General function prediction only];


Pssm-ID: 443666 [Multi-domain]  Cd Length: 161  Bit Score: 49.48  E-value: 4.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823389  59 LKVNsqvhtLGC--DYCGPLVEIARNRGCEVMVCDNLN--LPFRDQGFDAIISIGVIHHFsTKQRRIRAIKEMARVLAPG 134
Cdd:COG4627    5 LKLN-----IGCgpKRLPGWLNVDIVPAPGVDIVGDLTdpLPFPDNSVDAIYSSHVLEHL-DYEEAPLALKECYRVLKPG 78


                 ....*..
gi 157823389 135 GQLMIYV 141
Cdd:COG4627   79 GILRIVV 85
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 43-135 8.47e-06

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 46.10  E-value: 8.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823389  43 KPGSLIADIGCGTG------KYLKVNSqvhtLGCDYCGPLVEIAR-------NRGCEVMVCDNLNLPFRDQGFDAIIS-- 107
Cdd:COG1041   25 KEGDTVLDPFCGTGtilieaGLLGRRV----IGSDIDPKMVEGARenlehygYEDADVIRGDARDLPLADESVDAIVTdp 100

                         90       100       110
                 ....*....|....*....|....*....|..
gi 157823389 108 -IGVIHHFSTKQRRI---RAIKEMARVLAPGG 135
Cdd:COG1041  101 pYGRSSKISGEELLElyeKALEEAARVLKPGG 132
PLN02233 PLN02233
ubiquinone biosynthesis methyltransferase
 16-139 1.95e-05

ubiquinone biosynthesis methyltransferase


Pssm-ID: 177877 [Multi-domain]  Cd Length: 261  Bit Score: 46.04  E-value: 1.95e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823389  16 VYESTAPYFSDLQNKAWPRVRQFLQDQKPGSLIADIGCGTGK--YL---KVNSQVHTLGCDYCGPLVEIA------RNRG 84
Cdd:PLN02233  45 VYDNLNDLLSLGQHRIWKRMAVSWSGAKMGDRVLDLCCGSGDlaFLlseKVGSDGKVMGLDFSSEQLAVAasrqelKAKS 124

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 157823389  85 C----EVMVCDNLNLPFRDQGFDAIiSIGviHHFSTKQRRIRAIKEMARVLAPGGQLMI 139
Cdd:PLN02233 125 CykniEWIEGDATDLPFDDCYFDAI-TMG--YGLRNVVDRLKAMQEMYRVLKPGSRVSI 180
PLN02336 PLN02336
phosphoethanolamine N-methyltransferase
 41-139 1.05e-04

phosphoethanolamine N-methyltransferase


Pssm-ID: 177970 [Multi-domain]  Cd Length: 475  Bit Score: 44.36  E-value: 1.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823389  41 DQKPGSLIADIGCGTGK---YLKVNSQVHTLGCDYCGPLVEIA------RNRGCEVMVCDNLNLPFRDQGFDAIISIGVI 111
Cdd:PLN02336 263 DLKPGQKVLDVGCGIGGgdfYMAENFDVHVVGIDLSVNMISFAleraigRKCSVEFEVADCTKKTYPDNSFDVIYSRDTI 342

                         90       100
                 ....*....|....*....|....*...
gi 157823389 112 HHFSTKQRRIRAikeMARVLAPGGQLMI 139
Cdd:PLN02336 343 LHIQDKPALFRS---FFKWLKPGGKVLI 367
PTZ00098 PTZ00098
phosphoethanolamine N-methyltransferase; Provisional
 44-139 2.95e-04

phosphoethanolamine N-methyltransferase; Provisional


Pssm-ID: 173391 [Multi-domain]  Cd Length: 263  Bit Score: 42.26  E-value: 2.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823389  44 PGSLIADIGCGTG---KYLKVNSQVHTLGCDYCGPLVEIA--RNRG---CEVMVCDNLNLPFRDQGFDAIISIGVIHHFS 115
Cdd:PTZ00098  52 ENSKVLDIGSGLGggcKYINEKYGAHVHGVDICEKMVNIAklRNSDknkIEFEANDILKKDFPENTFDMIYSRDAILHLS 131

                         90       100
                 ....*....|....*....|....
gi 157823389 116 TKQRRiRAIKEMARVLAPGGQLMI 139
Cdd:PTZ00098 132 YADKK-KLFEKCYKWLKPNGILLI 154
rrmA PRK11088
23S rRNA methyltransferase A; Provisional
 34-137 3.40e-04

23S rRNA methyltransferase A; Provisional


Pssm-ID: 236841 [Multi-domain]  Cd Length: 272  Bit Score: 42.21  E-value: 3.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823389  34 RVRQFLQDQKPGS--LIADIGCGTGKY----LKVNSQVHTL---GCDYCGPLVEIARNR--GCEVMVCDNLNLPFRDQGF 102
Cdd:PRK11088  73 AVANLLAERLDEKatALLDIGCGEGYYthalADALPEITTMqlfGLDISKVAIKYAAKRypQVTFCVASSHRLPFADQSL 152

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 157823389 103 DAIIsigvihhfstkqrRIRA---IKEMARVLAPGGQL 137
Cdd:PRK11088 153 DAII-------------RIYApckAEELARVVKPGGIV 177
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 37-150 3.91e-04

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 41.33  E-value: 3.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823389  37 QFLQDQKPGSlIADIGCGTG----KYLKVNSQVHTLGCDYCGPLVEIAR-N------RGCEVMVCDNLNlPFRDQGFDAI 105
Cdd:COG2813   43 EHLPEPLGGR-VLDLGCGYGviglALAKRNPEARVTLVDVNARAVELARaNaaanglENVEVLWSDGLS-GVPDGSFDLI 120

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 157823389 106 IS-----IGVIHHFSTKQRRIRAIkemARVLAPGGQLMIyVWameqkNRH 150
Cdd:COG2813  121 LSnppfhAGRAVDKEVAHALIADA---ARHLRPGGELWL-VA-----NRH 161
PLN02490 PLN02490
MPBQ/MSBQ methyltransferase
 83-136 2.81e-03

MPBQ/MSBQ methyltransferase


Pssm-ID: 215270 [Multi-domain]  Cd Length: 340  Bit Score: 39.88  E-value: 2.81e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 157823389  83 RGCEVMVCDNLNLPFRDQGFDAIISIGVIHHFSTKQrriRAIKEMARVLAPGGQ 136
Cdd:PLN02490 160 KECKIIEGDAEDLPFPTDYADRYVSAGSIEYWPDPQ---RGIKEAYRVLKIGGK 210
PLN02232 PLN02232
ubiquinone biosynthesis methyltransferase
 91-139 6.28e-03

ubiquinone biosynthesis methyltransferase


Pssm-ID: 165876  Cd Length: 160  Bit Score: 37.36  E-value: 6.28e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 157823389  91 DNLNLPFRDQGFDAIiSIGviHHFSTKQRRIRAIKEMARVLAPGGQLMI 139
Cdd:PLN02232  34 DAIDLPFDDCEFDAV-TMG--YGLRNVVDRLRAMKEMYRVLKPGSRVSI 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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