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Conserved domains on  [gi|157821937|ref|NP_001101121|]
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DEP domain-containing protein 1B [Rattus norvegicus]

Protein Classification

Rho GTPase-activating protein( domain architecture ID 10138386)

Rho GTPase-activating protein for Rho/Rac/Cdc42-like small GTPases that act as molecular switches, active in their GTP-bound form but inactive when bound to GDP

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhoGAP_BRCC3-like cd04405
RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 177-400 9.42e-105

RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain and an N-terminal DEP (Disheveled, Egl-10, and Pleckstrin) domain. The function(s) of BRCC3 and DEPDC7 are unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


:

Pssm-ID: 239870  Cd Length: 235  Bit Score: 313.50  E-value: 9.42e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821937 177 LTEANVEEIWKSTTLSHLQRILGLDSLEEVLNTKLVNSKFIIHNV------YSVSKQGVVILDDKSkELPHWVLSAMKCL 250
Cdd:cd04405    1 LSPEVVEEIWKEQTLIRLLQLVGLPLLEELLDPALVNPKHISYNMdpdvytSNYLDREVVKLFSKS-QLDHWLLSAMDCL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821937 251 ANWPNCT--DWKQPMYL------GFEKDVFKTIADYYGHLKEPLLTFHLFDAFVSVLGLL--PKEQMATEAFQICCLLLP 320
Cdd:cd04405   80 ANWPDQLvvDVSRPLYSqhdmlsGFKRLLFKTIAKYYGQLKEPLLTFHLFDIFVGILELLgnGKEEVALEALQLCLLLLP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821937 321 PENRRKLQLLMRMMARICLNkEMPPLCDGFGTRTLMVQTFSRCILCSKdevDLDELLAARLVTFLMDNYQEILKVPLVLQ 400
Cdd:cd04405  160 PASRRELRRLLRFMARAAKN-DMPRLHKEIENRMLVKQTFSRAILCSK---DLDEGLADLLVLFLMDHHQDIFKVPGSLH 235
DEP_BRCC3 cd04447
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in BBRC3-like proteins. BBRC3, also ...
 15-106 1.08e-60

DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in BBRC3-like proteins. BBRC3, also known as DEPDC1B, is a DEP containing protein of unknown function.


:

Pssm-ID: 239894  Cd Length: 92  Bit Score: 194.68  E-value: 1.08e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821937  15 RLWNETVELFRARMPLRKHRCRFKSYEHCFTASEAVDWLHELLRNSQNFGPEVTRKQTVQLLRKFLKNHVIEDIKGKWGQ 94
Cdd:cd04447    1 KLWNEVTELFRAGMPLRKHRQHFKSYENCFTASEAVDWLHELLRSNSNFGPEVTRQQTVQLLKKFLKNHVIEDIKGRWGK 80

                         90
                 ....*....|..
gi 157821937  95 EDFEDNRHLYRF 106
Cdd:cd04447   81 EDLEDNNHLYRF 92
 
Name Accession Description Interval E-value
RhoGAP_BRCC3-like cd04405
RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 177-400 9.42e-105

RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain and an N-terminal DEP (Disheveled, Egl-10, and Pleckstrin) domain. The function(s) of BRCC3 and DEPDC7 are unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239870  Cd Length: 235  Bit Score: 313.50  E-value: 9.42e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821937 177 LTEANVEEIWKSTTLSHLQRILGLDSLEEVLNTKLVNSKFIIHNV------YSVSKQGVVILDDKSkELPHWVLSAMKCL 250
Cdd:cd04405    1 LSPEVVEEIWKEQTLIRLLQLVGLPLLEELLDPALVNPKHISYNMdpdvytSNYLDREVVKLFSKS-QLDHWLLSAMDCL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821937 251 ANWPNCT--DWKQPMYL------GFEKDVFKTIADYYGHLKEPLLTFHLFDAFVSVLGLL--PKEQMATEAFQICCLLLP 320
Cdd:cd04405   80 ANWPDQLvvDVSRPLYSqhdmlsGFKRLLFKTIAKYYGQLKEPLLTFHLFDIFVGILELLgnGKEEVALEALQLCLLLLP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821937 321 PENRRKLQLLMRMMARICLNkEMPPLCDGFGTRTLMVQTFSRCILCSKdevDLDELLAARLVTFLMDNYQEILKVPLVLQ 400
Cdd:cd04405  160 PASRRELRRLLRFMARAAKN-DMPRLHKEIENRMLVKQTFSRAILCSK---DLDEGLADLLVLFLMDHHQDIFKVPGSLH 235
DEP_BRCC3 cd04447
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in BBRC3-like proteins. BBRC3, also ...
 15-106 1.08e-60

DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in BBRC3-like proteins. BBRC3, also known as DEPDC1B, is a DEP containing protein of unknown function.


Pssm-ID: 239894  Cd Length: 92  Bit Score: 194.68  E-value: 1.08e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821937  15 RLWNETVELFRARMPLRKHRCRFKSYEHCFTASEAVDWLHELLRNSQNFGPEVTRKQTVQLLRKFLKNHVIEDIKGKWGQ 94
Cdd:cd04447    1 KLWNEVTELFRAGMPLRKHRQHFKSYENCFTASEAVDWLHELLRSNSNFGPEVTRQQTVQLLKKFLKNHVIEDIKGRWGK 80

                         90
                 ....*....|..
gi 157821937  95 EDFEDNRHLYRF 106
Cdd:cd04447   81 EDLEDNNHLYRF 92
DEP pfam00610
Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP); The DEP domain is responsible for ...
 27-106 5.23e-19

Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP); The DEP domain is responsible for mediating intracellular protein targeting and regulation of protein stability in the cell. The DEP domain is present in a number of signaling molecules, including Regulator of G protein Signaling (RGS) proteins, and has been implicated in membrane targeting. New findings in yeast, however, demonstrate a major role for a DEP domain in mediating the interaction of an RGS protein to the C-terminal tail of a GPCR, thus placing RGS in close proximity with its substrate G protein alpha subunit.


Pssm-ID: 459867  Cd Length: 71  Bit Score: 81.10  E-value: 5.23e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821937   27 RMPLRKHRCRFKSYEHCFTASEAVDWLHELlrnsqnfGPEVTRKQTVQLLRKFLKNHVIEDIKGKWGQedFEDNRHLYRF 106
Cdd:pfam00610   1 GVKLKDRRKHLKTYPNCFTGSEAVDWLMDN-------LEIITREEAVELGQLLLDQGLIHHVGDKHGL--FKDSYYFYRF 71
DEP smart00049
Domain found in Dishevelled, Egl-10, and Pleckstrin; Domain of unknown function present in ...
 24-108 2.95e-15

Domain found in Dishevelled, Egl-10, and Pleckstrin; Domain of unknown function present in signalling proteins that contain PH, rasGEF, rhoGEF, rhoGAP, RGS, PDZ domains. DEP domain in Drosophila dishevelled is essential to rescue planar polarity defects and induce JNK signalling (Cell 94, 109-118).


Pssm-ID: 214489  Cd Length: 77  Bit Score: 70.78  E-value: 2.95e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821937    24 FRARMPLRKHRCRFKSYEHCFTASEAVDWLHELLRNSqnfgpevTRKQTVQLLRKFLKNHVIEDIKGkWGQEDFEDNRHL 103
Cdd:smart00049   1 PETGLKLRDRKYFLKTYPNCFTGSELVDWLMDNLEII-------DREEAVHLGQLLLDEGLIHHVNG-PNKHTFKDSKAL 72


                   ....*
gi 157821937   104 YRFPP 108
Cdd:smart00049  73 YRFTT 77
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 282-342 6.04e-06

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 46.00  E-value: 6.04e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157821937  282 LKEPLLTFHLFDAFVSVLGLLPKEQmATEAFQICCLLLPPENRRKLQLLMRMMARICLNKE 342
Cdd:pfam00620  67 LPEPLLTFELYEEFIEAAKLPDEEE-RLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSD 126
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 282-342 4.09e-05

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 44.18  E-value: 4.09e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157821937   282 LKEPLLTFHLFDAFVSVLgLLPKEQMATEAFQICCLLLPPENRRKLQLLMRMMARICLNKE 342
Cdd:smart00324  70 LPEPLITYELYEEFIEAA-KLEDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSE 129
 
Name Accession Description Interval E-value
RhoGAP_BRCC3-like cd04405
RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 177-400 9.42e-105

RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain and an N-terminal DEP (Disheveled, Egl-10, and Pleckstrin) domain. The function(s) of BRCC3 and DEPDC7 are unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239870  Cd Length: 235  Bit Score: 313.50  E-value: 9.42e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821937 177 LTEANVEEIWKSTTLSHLQRILGLDSLEEVLNTKLVNSKFIIHNV------YSVSKQGVVILDDKSkELPHWVLSAMKCL 250
Cdd:cd04405    1 LSPEVVEEIWKEQTLIRLLQLVGLPLLEELLDPALVNPKHISYNMdpdvytSNYLDREVVKLFSKS-QLDHWLLSAMDCL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821937 251 ANWPNCT--DWKQPMYL------GFEKDVFKTIADYYGHLKEPLLTFHLFDAFVSVLGLL--PKEQMATEAFQICCLLLP 320
Cdd:cd04405   80 ANWPDQLvvDVSRPLYSqhdmlsGFKRLLFKTIAKYYGQLKEPLLTFHLFDIFVGILELLgnGKEEVALEALQLCLLLLP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821937 321 PENRRKLQLLMRMMARICLNkEMPPLCDGFGTRTLMVQTFSRCILCSKdevDLDELLAARLVTFLMDNYQEILKVPLVLQ 400
Cdd:cd04405  160 PASRRELRRLLRFMARAAKN-DMPRLHKEIENRMLVKQTFSRAILCSK---DLDEGLADLLVLFLMDHHQDIFKVPGSLH 235
DEP_BRCC3 cd04447
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in BBRC3-like proteins. BBRC3, also ...
 15-106 1.08e-60

DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in BBRC3-like proteins. BBRC3, also known as DEPDC1B, is a DEP containing protein of unknown function.


Pssm-ID: 239894  Cd Length: 92  Bit Score: 194.68  E-value: 1.08e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821937  15 RLWNETVELFRARMPLRKHRCRFKSYEHCFTASEAVDWLHELLRNSQNFGPEVTRKQTVQLLRKFLKNHVIEDIKGKWGQ 94
Cdd:cd04447    1 KLWNEVTELFRAGMPLRKHRQHFKSYENCFTASEAVDWLHELLRSNSNFGPEVTRQQTVQLLKKFLKNHVIEDIKGRWGK 80

                         90
                 ....*....|..
gi 157821937  95 EDFEDNRHLYRF 106
Cdd:cd04447   81 EDLEDNNHLYRF 92
DEP pfam00610
Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP); The DEP domain is responsible for ...
 27-106 5.23e-19

Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP); The DEP domain is responsible for mediating intracellular protein targeting and regulation of protein stability in the cell. The DEP domain is present in a number of signaling molecules, including Regulator of G protein Signaling (RGS) proteins, and has been implicated in membrane targeting. New findings in yeast, however, demonstrate a major role for a DEP domain in mediating the interaction of an RGS protein to the C-terminal tail of a GPCR, thus placing RGS in close proximity with its substrate G protein alpha subunit.


Pssm-ID: 459867  Cd Length: 71  Bit Score: 81.10  E-value: 5.23e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821937   27 RMPLRKHRCRFKSYEHCFTASEAVDWLHELlrnsqnfGPEVTRKQTVQLLRKFLKNHVIEDIKGKWGQedFEDNRHLYRF 106
Cdd:pfam00610   1 GVKLKDRRKHLKTYPNCFTGSEAVDWLMDN-------LEIITREEAVELGQLLLDQGLIHHVGDKHGL--FKDSYYFYRF 71
DEP cd04371
DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first ...
 24-105 6.70e-17

DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is present. New studies show that the DEP domain of Sst2, a yeast RGS protein is necessary and sufficient for receptor interaction.


Pssm-ID: 239836  Cd Length: 81  Bit Score: 75.45  E-value: 6.70e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821937  24 FRARMPLRKHRCRFKSYEHCFTASEAVDWLHEllrnsqnFGPEVTRKQTVQLLRKFLKNHVIEDIKGkwGQEDFEDNRHL 103
Cdd:cd04371    9 SDSGVPIKDRKYHLKTYPNCFTGSELVDWLLD-------NLEAITREEAVELGQALLKHGLIHHVSD--DKHTFRDSYAL 79


                 ..
gi 157821937 104 YR 105
Cdd:cd04371   80 YR 81
DEP smart00049
Domain found in Dishevelled, Egl-10, and Pleckstrin; Domain of unknown function present in ...
 24-108 2.95e-15

Domain found in Dishevelled, Egl-10, and Pleckstrin; Domain of unknown function present in signalling proteins that contain PH, rasGEF, rhoGEF, rhoGAP, RGS, PDZ domains. DEP domain in Drosophila dishevelled is essential to rescue planar polarity defects and induce JNK signalling (Cell 94, 109-118).


Pssm-ID: 214489  Cd Length: 77  Bit Score: 70.78  E-value: 2.95e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821937    24 FRARMPLRKHRCRFKSYEHCFTASEAVDWLHELLRNSqnfgpevTRKQTVQLLRKFLKNHVIEDIKGkWGQEDFEDNRHL 103
Cdd:smart00049   1 PETGLKLRDRKYFLKTYPNCFTGSELVDWLMDNLEII-------DREEAVHLGQLLLDEGLIHHVNG-PNKHTFKDSKAL 72


                   ....*
gi 157821937   104 YRFPP 108
Cdd:smart00049  73 YRFTT 77
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 270-388 1.72e-11

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 62.70  E-value: 1.72e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821937 270 DVFKTIADYYGHLKEPLLTFHLFDAFVSVLGLLPKEQmATEAFQICCLLLPPENRRKLQLLMRMMARICLNKEMpplcdg 349
Cdd:cd00159   54 DVASLLKLYLRELPEPLIPFELYDEFIELAKIEDEEE-RIEALKELLKSLPPENRDLLKYLLKLLHKISQNSEV------ 126

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 157821937 350 fgtrTLM-VQT----FSRCILCSKDEVD---LDELLAARLVTFLMDN 388
Cdd:cd00159  127 ----NKMtASNlaivFAPTLLRPPDSDDellEDIKKLNEIVEFLIEN 169
DEP_DEPDC4 cd04446
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC4-like proteins. DEPDC4 is a ...
 17-105 5.18e-11

DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC4-like proteins. DEPDC4 is a DEP domain containing protein of unknown function.


Pssm-ID: 239893  Cd Length: 95  Bit Score: 59.30  E-value: 5.18e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821937  17 WNETVELFRARMPLRKHRCRFKSYEHCFTASEAVDWLHELLRNSQNFG-PEVTRKQTVQLLRKFLKNHVIEDIKGKWGQE 95
Cdd:cd04446    1 WNSIIDALQTQVEVKKRRHNLKSYHDCFLGSEAVDVVLAHLMQNKYFGdVDVPRAKAVRLCQALMDCRVFEAVGTKVFKK 80

                         90
                 ....*....|....*
gi 157821937  96 D----FED-NRHLYR 105
Cdd:cd04446   81 KkravFEDsSSSLYR 95
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 270-396 9.82e-08

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 52.81  E-value: 9.82e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821937 270 DVFKTIADYYGHLKEPLLTFHLFDAFVSVLGLLPKEQMAtEAFQICCLLLPPENRRKLQLLMRMMARICLN---KEMPP- 345
Cdd:cd04375   74 DVADMLKQYFRDLPEPLLTNKLSETFIAIFQYVPKEQRL-EAVQCAILLLPDENREVLQTLLYFLSDVAANsqeNQMTAt 152

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157821937 346 ---LCDG-----FGTRTLMVQTFSRCI-----LCSKDEVDLDELLAARL-VTFLMDNYQEILKVP 396
Cdd:cd04375  153 nlaVCLApslfhLNTSRRENSSPARRMqrkksLGKPDQKELSENKAAHQcLAYMIEECNTLFMVP 217
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 282-342 2.39e-06

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 48.50  E-value: 2.39e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157821937 282 LKEPLLTFHLFDAFVSVLGLlPKEQMATEAFQICCLLLPPENRRKLQLLMRMMARICLNKE 342
Cdd:cd04391   90 LPQPLLTVEYLPAFYSVQGL-PSKKDQLQALNLLVLLLPEANRDTLKALLEFLQKVVDHEE 149
DEP_GPR155 cd04443
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in GPR155-like proteins. GRP155-like ...
 34-106 2.76e-06

DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in GPR155-like proteins. GRP155-like proteins, also known as PGR22, contain an N-terminal permease domain, a central transmembrane region and a C-terminal DEP domain. They are orphan receptors of the class B G protein-coupled receptors. Their function is unknown.


Pssm-ID: 239890 [Multi-domain]  Cd Length: 83  Bit Score: 45.40  E-value: 2.76e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 157821937  34 RCRFKSYEHCFTASEAVDWLHELlrnsqnfGPEVTRKQTVQLLRKFLKNHVIEDIKgkwGQEDFEDNRHLYRF 106
Cdd:cd04443   21 RCGLRTYKGVFCGCDLVSWLIEV-------GLAQDRGEAVLYGRRLLQGGVLQHIT---NEHHFRDENLLYRF 83
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 282-342 6.04e-06

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 46.00  E-value: 6.04e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157821937  282 LKEPLLTFHLFDAFVSVLGLLPKEQmATEAFQICCLLLPPENRRKLQLLMRMMARICLNKE 342
Cdd:pfam00620  67 LPEPLLTFELYEEFIEAAKLPDEEE-RLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSD 126
DEP_PIKfyve cd04448
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange ...
 16-53 2.43e-05

DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol phosphate kinase) domain. PIKfyve-like proteins are important phosphatidylinositol (3)-monophosphate (PtdIns(3)P)-5-kinases, producing PtdIns(3,5)P2, which plays a major role in multivesicular body (MVB) sorting and control of retrograde traffic from the vacuole back to the endosome and/or Golgi. PIKfyve itself has been shown to be play a role in regulating early-endosome-to-trans-Golgi network (TGN) retrograde trafficking.


Pssm-ID: 239895  Cd Length: 81  Bit Score: 42.82  E-value: 2.43e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 157821937  16 LWnetVELFRAR--MPLRKHRCRFKSYEHCFTASEAVDWL 53
Cdd:cd04448    2 LW---EKICRSStgIEFQDHRYRLRTYTNCILGKELVNWL 38
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 270-396 2.53e-05

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 45.51  E-value: 2.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821937 270 DVFKTIADYYGHLKEPLLTFHLFDAFVSVLGLLPKEQMatEAFQICCLLLPPENRRKLQLLMRMMARICLNKEMPPLCDG 349
Cdd:cd04376   63 DVAALLKEFFRDMPDPLLPRELYTAFIGTALLEPDEQL--EALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAADSIDEDG 140

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 157821937 350 ----------------FGTRTLMVQTFS-RCILCSKDEVDlDELLAARLVTFLMDNYQEILKVP 396
Cdd:cd04376  141 qevsgnkmtslnlatiFGPNLLHKQKSGeREFVQASLRIE-ESTAIINVVQTMIDNYEELFMVS 203
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 282-342 4.09e-05

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 44.18  E-value: 4.09e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157821937   282 LKEPLLTFHLFDAFVSVLgLLPKEQMATEAFQICCLLLPPENRRKLQLLMRMMARICLNKE 342
Cdd:smart00324  70 LPEPLITYELYEEFIEAA-KLEDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSE 129
DEP_2_DEP6 cd04441
DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in DEP6-like proteins. DEP6 proteins ...
 40-106 3.54e-04

DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in DEP6-like proteins. DEP6 proteins contain two DEP and a PDZ domain. Their function is unknown.


Pssm-ID: 239888  Cd Length: 85  Bit Score: 39.34  E-value: 3.54e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157821937  40 YEHCFTASEAVDWL-HEllrnsqnfGPEVTRKQTVQLLRKFLKNHVIEDIKGKwgqEDFEDNRHLYRF 106
Cdd:cd04441   29 YERTFVGSEFIDWLlQE--------GEAESRREAVQLCRRLLEHGIIQHVSNK---HHFFDSNLLYQF 85
DEP_DEPDC5-like cd04449
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in ...
 37-106 5.62e-04

DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.


Pssm-ID: 239896  Cd Length: 83  Bit Score: 38.80  E-value: 5.62e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821937  37 FKSYEHCFTASEAVDWLHEllrnsqNFGPEVTRKQTVQLLRKFLKNHVIEDIKGKWGqedFEDNRHLYRF 106
Cdd:cd04449   23 KGLPSNCFIGSEAVSWLIN------NFEDVDTREEAVELGQELMNEGLIEHVSGRHP---FLDGFYFYYI 83
DEP_1_DEP6 cd04442
DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in DEP6-like proteins. DEP6 proteins ...
 20-106 2.06e-03

DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in DEP6-like proteins. DEP6 proteins contain two DEP and a PDZ domain. Their function is unknown.


Pssm-ID: 239889 [Multi-domain]  Cd Length: 82  Bit Score: 37.18  E-value: 2.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821937  20 TVELFRARM---PLRKHRCR-FKSYEHCFTASEAVDWLHELLRNSQnfgpevtRKQTVQLLRKFLKNHVIEDIKGKwgQE 95
Cdd:cd04442    1 TGEQLRLRLheaKVIKDRRHhLRTYPNCFVGKELIDWLIEHKEASD-------RETAIKIMQKLLDHSIIHHVCDE--HK 71

                         90
                 ....*....|.
gi 157821937  96 DFEDNRHLYRF 106
Cdd:cd04442   72 EFKDAKLFYRF 82
DEP_Epac cd04437
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange ...
 31-107 2.12e-03

DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by cyclic AMP, a second messenger that plays a role in the control of diverse cellular processes, such as cell adhesion and insulin secretion. Epac-like proteins share a common domain architecture, containing RasGEF, DEP and CAP-effector (cAMP binding) domains. The DEP domain is involved in membrane localization.


Pssm-ID: 239884  Cd Length: 125  Bit Score: 38.48  E-value: 2.12e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 157821937  31 RKHRcrFKSYEHCFTASEAVDWLHELLRNSQnfgpevTRKQTVQLLRKFLKNHVIEDIKGKWGqedFEDNRHLYRFP 107
Cdd:cd04437   20 RKYH--LRTYRQCCVGTELVDWLLQQSPCVQ------SRSQAVGMWQVLLEEGVLLHVDQELH---FQDKYQFYRFS 85
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 270-403 3.29e-03

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 38.98  E-value: 3.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821937 270 DVFKTIADYYGHLKEPLLTFHLFDAFVSVLGLL-----------PKEQMATEAFQICCLLLPPENRRKLQLLMRMMARIC 338
Cdd:cd04392   63 DCATVLKGFLGELPEPLLTHAHYPAHLQIADLCqfdekgnktsaPDKERLLEALQLLLLLLPEENRNLLKLILDLLYQTA 142

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157821937 339 lNKEMPPLCDGFGTRTLmvqtFSRCILCSKDEV--DLDELLA--ARLVTFLMDNYQEILKVPLVLQTSI 403
Cdd:cd04392  143 -KHEDKNKMSADNLALL----FTPHLICPRNLTpeDLHENAQklNSIVTFMIKHSQKLFKAPAYLREDA 206
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 282-405 4.81e-03

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 38.19  E-value: 4.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821937 282 LKEPLLTFHLFDAFVSVLGLLPKEQmateafQICCL-----LLPPENRRKLQLLMRMMARICLNKEMpplcDGFGTRTLM 356
Cdd:cd04377   81 LPEPLMTFELYENFLRAMELEEKQE------RVRALysvleQLPRANLNTLERLIFHLVRVALQEEV----NRMSANALA 150

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 157821937 357 VqTFSRCILCSKDEVDldellaarlvtfLMDNYQEILKVPLVLQTSIEE 405
Cdd:cd04377  151 I-VFAPCILRCPDTAD------------PLQSLQDVSKTTTCVETLIKE 186
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 282-392 5.50e-03

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 38.09  E-value: 5.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821937 282 LKEPLLTFHLFDAFVSVLGlLPKEQMATEAFQIcCLLLPPENRRKLQLLM----RMMARICLNKeMpplcdgfgTRTLMV 357
Cdd:cd04404   89 LPEPLLTFDLYDDIVGFLN-VDKEERVERVKQL-LQTLPEENYQVLKYLIkflvQVSAHSDQNK-M--------TNSNLA 157

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 157821937 358 QTFSRCILCSKD-EVDLDELLAARLVT-FLMDNYQEI 392
Cdd:cd04404  158 VVFGPNLLWAKDaSMSLSAINPINTFTkFLLDHQDEI 194
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 278-338 6.95e-03

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 37.87  E-value: 6.95e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157821937 278 YYGHLKEPLLTFHLFDAFVSVLGLLPKEQmATEAFQICCLLLPPENRRKLQLLMRMMARIC 338
Cdd:cd04384   82 YFRELPNPLLTYQLYEKFSEAVSAASDEE-RLEKIHDVIQQLPPPHYRTLEFLMRHLSRLA 141
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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