NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|157821217|ref|NP_001101249|]
View 

tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 [Rattus norvegicus]

Protein Classification

tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6( domain architecture ID 10514648)

tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 is the substrate-binding subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Gcd10p pfam04189
Gcd10p family; eIF-3 is a multi-subunit complex that stimulates translation initiation in ...
 21-261 1.76e-81

Gcd10p family; eIF-3 is a multi-subunit complex that stimulates translation initiation in vitro at several different steps. This family corresponds to the gamma subunit if eIF3. The Yeast protein Gcd10p has also been shown to be part of a complex with the methyltransferase Gcd14p that is involved in modifying tRNA.


:

Pssm-ID: 461216  Cd Length: 295  Bit Score: 254.79  E-value: 1.76e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821217   21 IHDGDFVVLK-REDVFKAVQVQRRKKVTFEKQW-FYLDNAIGHSYGSTFEVSSGGSLQLRKKL----------------- 81
Cdd:pfam04189   2 IRPNQHVILRlPSGNLKIVQLKPNTTISLGKFGsFPVNLIIGRPYGLTFEILDKRGEESFSKLrvvpaaelhaeslaeee 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821217   82 -EEPTSETKEAGTDNRNIVDDGKSQKLTQDDIKALKDKGIK-GEEIVQQLIENSTTFRDKTEFAQDKYIKKKKKKYEAII 159
Cdd:pfam04189  82 aDSEEGEGEVSSRDNRNIIDDGSRQKLTMEEIEELKKQGASaGKEIIAKLIESHTTFDQKTAFSQEKYLKRKKKKYLKRF 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821217  160 TILKPSTRILSIMYYA-REPGKINHMRYDTLAQMLTLGNIRAGNKMIVMETCSGLVLGAMMERMGG--FGSIIQLYPGDG 236
Cdd:pfam04189 162 TVLPLDVSLLLEYYLEkKDPQKILDLREETLGLLLTWANVHPGGRYLVVDETGGLLVAAMAERMGGatTGTITVIHPNEQ 241

                         250       260
                  ....*....|....*....|....*.
gi 157821217  237 PVRAATACFGF-PKSFLSGlHEFPLN 261
Cdd:pfam04189 242 PNLSLLKYFNYdPEHPLDT-HLKTLS 266
 
Name Accession Description Interval E-value
Gcd10p pfam04189
Gcd10p family; eIF-3 is a multi-subunit complex that stimulates translation initiation in ...
 21-261 1.76e-81

Gcd10p family; eIF-3 is a multi-subunit complex that stimulates translation initiation in vitro at several different steps. This family corresponds to the gamma subunit if eIF3. The Yeast protein Gcd10p has also been shown to be part of a complex with the methyltransferase Gcd14p that is involved in modifying tRNA.


Pssm-ID: 461216  Cd Length: 295  Bit Score: 254.79  E-value: 1.76e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821217   21 IHDGDFVVLK-REDVFKAVQVQRRKKVTFEKQW-FYLDNAIGHSYGSTFEVSSGGSLQLRKKL----------------- 81
Cdd:pfam04189   2 IRPNQHVILRlPSGNLKIVQLKPNTTISLGKFGsFPVNLIIGRPYGLTFEILDKRGEESFSKLrvvpaaelhaeslaeee 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821217   82 -EEPTSETKEAGTDNRNIVDDGKSQKLTQDDIKALKDKGIK-GEEIVQQLIENSTTFRDKTEFAQDKYIKKKKKKYEAII 159
Cdd:pfam04189  82 aDSEEGEGEVSSRDNRNIIDDGSRQKLTMEEIEELKKQGASaGKEIIAKLIESHTTFDQKTAFSQEKYLKRKKKKYLKRF 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821217  160 TILKPSTRILSIMYYA-REPGKINHMRYDTLAQMLTLGNIRAGNKMIVMETCSGLVLGAMMERMGG--FGSIIQLYPGDG 236
Cdd:pfam04189 162 TVLPLDVSLLLEYYLEkKDPQKILDLREETLGLLLTWANVHPGGRYLVVDETGGLLVAAMAERMGGatTGTITVIHPNEQ 241

                         250       260
                  ....*....|....*....|....*.
gi 157821217  237 PVRAATACFGF-PKSFLSGlHEFPLN 261
Cdd:pfam04189 242 PNLSLLKYFNYdPEHPLDT-HLKTLS 266
 
Name Accession Description Interval E-value
Gcd10p pfam04189
Gcd10p family; eIF-3 is a multi-subunit complex that stimulates translation initiation in ...
 21-261 1.76e-81

Gcd10p family; eIF-3 is a multi-subunit complex that stimulates translation initiation in vitro at several different steps. This family corresponds to the gamma subunit if eIF3. The Yeast protein Gcd10p has also been shown to be part of a complex with the methyltransferase Gcd14p that is involved in modifying tRNA.


Pssm-ID: 461216  Cd Length: 295  Bit Score: 254.79  E-value: 1.76e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821217   21 IHDGDFVVLK-REDVFKAVQVQRRKKVTFEKQW-FYLDNAIGHSYGSTFEVSSGGSLQLRKKL----------------- 81
Cdd:pfam04189   2 IRPNQHVILRlPSGNLKIVQLKPNTTISLGKFGsFPVNLIIGRPYGLTFEILDKRGEESFSKLrvvpaaelhaeslaeee 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821217   82 -EEPTSETKEAGTDNRNIVDDGKSQKLTQDDIKALKDKGIK-GEEIVQQLIENSTTFRDKTEFAQDKYIKKKKKKYEAII 159
Cdd:pfam04189  82 aDSEEGEGEVSSRDNRNIIDDGSRQKLTMEEIEELKKQGASaGKEIIAKLIESHTTFDQKTAFSQEKYLKRKKKKYLKRF 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821217  160 TILKPSTRILSIMYYA-REPGKINHMRYDTLAQMLTLGNIRAGNKMIVMETCSGLVLGAMMERMGG--FGSIIQLYPGDG 236
Cdd:pfam04189 162 TVLPLDVSLLLEYYLEkKDPQKILDLREETLGLLLTWANVHPGGRYLVVDETGGLLVAAMAERMGGatTGTITVIHPNEQ 241

                         250       260
                  ....*....|....*....|....*.
gi 157821217  237 PVRAATACFGF-PKSFLSGlHEFPLN 261
Cdd:pfam04189 242 PNLSLLKYFNYdPEHPLDT-HLKTLS 266
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH