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Conserved domains on  [gi|157823759|ref|NP_001101541|]
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ADAMTS-like protein 5 isoform 6 precursor [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ADAMTS_CR_3 super family cl41950
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 102-201 6.87e-12

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


The actual alignment was detected with superfamily member pfam19236:

Pssm-ID: 437068  Cd Length: 115  Bit Score: 60.88  E-value: 6.87e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823759  102 IPFRDLQCSLYNGHPVL---GTQKTYQW---VPFHGAPNLCDLNCLAEGHAFYHSFG-RVLDGTPCTP------GTQGLC 168
Cdd:pfam19236   3 LEFMSQQCARTDGQPLRsspGGASFYHWgaaVPHSQGDALCRHMCRAIGESFIMKRGdSFLDGTRCMPsgpredGTLSLC 82

                          90       100       110
                  ....*....|....*....|....*....|...
gi 157823759  169 VAGRCLSAGCDGLLGSGTLEDRCGLCGGANDSC 201
Cdd:pfam19236  83 VLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 49-98 3.70e-10

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 54.13  E-value: 3.70e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 157823759    49 WTLWGSWSRCSSSCGRGVSVRRRHCVRLPE---EELCWGDSHEYRVCQLPDCP 98
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPqngGGPCTGEDVETRACNEQPCP 53
 
Name Accession Description Interval E-value
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 102-201 6.87e-12

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 60.88  E-value: 6.87e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823759  102 IPFRDLQCSLYNGHPVL---GTQKTYQW---VPFHGAPNLCDLNCLAEGHAFYHSFG-RVLDGTPCTP------GTQGLC 168
Cdd:pfam19236   3 LEFMSQQCARTDGQPLRsspGGASFYHWgaaVPHSQGDALCRHMCRAIGESFIMKRGdSFLDGTRCMPsgpredGTLSLC 82

                          90       100       110
                  ....*....|....*....|....*....|...
gi 157823759  169 VAGRCLSAGCDGLLGSGTLEDRCGLCGGANDSC 201
Cdd:pfam19236  83 VLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 49-98 3.70e-10

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 54.13  E-value: 3.70e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 157823759    49 WTLWGSWSRCSSSCGRGVSVRRRHCVRLPE---EELCWGDSHEYRVCQLPDCP 98
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPqngGGPCTGEDVETRACNEQPCP 53
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 52-97 7.05e-06

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 42.27  E-value: 7.05e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 157823759   52 WGSWSRCSSSCGRGVSVRRRHCVRLPEE--ELCwGDSHEYRVCQLPDC 97
Cdd:pfam19028   6 WSEWSECSVTCGGGVQTRTRTVIVEPQNggRPC-PELLERRPCNLPPC 52
PTZ00087 PTZ00087
thrombosponding-related protein; Provisional
 49-99 5.35e-05

thrombosponding-related protein; Provisional


Pssm-ID: 185438  Cd Length: 340  Bit Score: 43.78  E-value: 5.35e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 157823759  49 WTLWGSWSRCSSSCGR--GVSVRRRHCVRlPEEELCWGDSHEYRVCQLPdCPP 99
Cdd:PTZ00087 233 YTEWGEWSNCSMECDHpdNVQIRERKCAH-PSGDCFKGDLKETRPCQVP-LPP 283
 
Name Accession Description Interval E-value
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 102-201 6.87e-12

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 60.88  E-value: 6.87e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823759  102 IPFRDLQCSLYNGHPVL---GTQKTYQW---VPFHGAPNLCDLNCLAEGHAFYHSFG-RVLDGTPCTP------GTQGLC 168
Cdd:pfam19236   3 LEFMSQQCARTDGQPLRsspGGASFYHWgaaVPHSQGDALCRHMCRAIGESFIMKRGdSFLDGTRCMPsgpredGTLSLC 82

                          90       100       110
                  ....*....|....*....|....*....|...
gi 157823759  169 VAGRCLSAGCDGLLGSGTLEDRCGLCGGANDSC 201
Cdd:pfam19236  83 VLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 49-98 3.70e-10

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 54.13  E-value: 3.70e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 157823759    49 WTLWGSWSRCSSSCGRGVSVRRRHCVRLPE---EELCWGDSHEYRVCQLPDCP 98
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPqngGGPCTGEDVETRACNEQPCP 53
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 52-97 7.05e-06

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 42.27  E-value: 7.05e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 157823759   52 WGSWSRCSSSCGRGVSVRRRHCVRLPEE--ELCwGDSHEYRVCQLPDC 97
Cdd:pfam19028   6 WSEWSECSVTCGGGVQTRTRTVIVEPQNggRPC-PELLERRPCNLPPC 52
TSP_1 pfam00090
Thrombospondin type 1 domain;
50-97 8.81e-06

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 42.02  E-value: 8.81e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 157823759   50 TLWGSWSRCSSSCGRGVSVRRRHCV-RLPEEELCWGDSHEYRVCQLPDC 97
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCKsPFPGGEPCTGDDIETQACKMDKC 49
PTZ00087 PTZ00087
thrombosponding-related protein; Provisional
 49-99 5.35e-05

thrombosponding-related protein; Provisional


Pssm-ID: 185438  Cd Length: 340  Bit Score: 43.78  E-value: 5.35e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 157823759  49 WTLWGSWSRCSSSCGR--GVSVRRRHCVRlPEEELCWGDSHEYRVCQLPdCPP 99
Cdd:PTZ00087 233 YTEWGEWSNCSMECDHpdNVQIRERKCAH-PSGDCFKGDLKETRPCQVP-LPP 283
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 53-97 3.16e-04

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 37.82  E-value: 3.16e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 157823759   53 GSWSRCSSSCGRGVSVRRRHCVR-----LPEEELCWGDS--HEYRVCQLPDC 97
Cdd:pfam19030   4 GPWGECSVTCGGGVQTRLVQCVQkgggsIVPDSECSAQKkpPETQSCNLKPC 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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