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Conserved domains on  [gi|157822141|ref|NP_001101591|]
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kelch repeat and BTB domain-containing protein 3 [Rattus norvegicus]

Protein Classification

kelch-like protein; Kelch-like protein 36( domain architecture ID 13033267)

kelch-like protein may act as substrate adaptors for Cullin 3 ubiquitin ligases; Kelch-like protein 36 (KLHL36) is a probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-153 4.60e-85

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 261.31  E-value: 4.60e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  24 FLASEDHGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFL 103
Cdd:cd18271    1 SLVAECHGQQILSVLQNFREQNAFFDFNIIVKDETIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTISNLSPKAVKAFL 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 157822141 104 DYAYTGKTRITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSISLVNCLHL 153
Cdd:cd18271   81 DYAYTGKAEITDDNVEMFFQMSSFLQVSLLSKACSDFLIKSIDLTNCLQL 130
PHA03098 super family cl33709
kelch-like protein; Provisional
 38-595 2.58e-46

kelch-like protein; Provisional


The actual alignment was detected with superfamily member PHA03098:

Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 171.10  E-value: 2.58e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  38 LQSFREQNVFydfkIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDdgsVTItNLSSKAVKAFLDYAYTGKTRITDDN 117
Cdd:PHA03098   6 LQKFCDESII----IVNGGGIIKVHKIILSSSSEYFKKMFKNNFKENE---INL-NIDYDSFNEVIKYIYTGKINITSNN 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 118 VEMFFQLSSFLQVSFLSKACSDFLIKSISLVNCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKC 197
Cdd:PHA03098  78 VKDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKI 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 198 LESDELNVPEEEMVLKAVLTWIKYNVESRQKHLPHLIAKVRLHQLSEASLQDCLLNEEYLLKSTNCFETIVDAIKRVQG- 276
Cdd:PHA03098 158 LSDDKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLRITFLSEEGIKKLKRWKLRIKKKKIVFNKRCIKIIYSKKy 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 277 -SSGLFPDARPSTTEKYIfihKTEENGENQYTFCYNIKTDSWKILSQSHLIDLPGSSLssYGEKIFLTGGC--KGKCCRK 353
Cdd:PHA03098 238 nLNKILPRSSTFGSIIYI---HITMSIFTYNYITNYSPLSEINTIIDIHYVYCFGSVV--LNNVIYFIGGMnkNNLSVNS 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 354 VrlhiaESYHDATdqtwcycpikNEFFFVSTMKTPRTMHTSVTALNRLFVIGGKTRGSqdikSLLDVESYDPLSKEWTSV 433
Cdd:PHA03098 313 V-----VSYDTKT----------KSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSI----SLNTVESWKPGESKWREE 373

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 434 SPLprgiYYPEASAC----QNVIYVLGSEVEiadaFNPSLDCFFKYNATTDQWSELV------AEFGQFFHATLIKAvpV 503
Cdd:PHA03098 374 PPL----IFPRYNPCvvnvNNLIYVIGGISK----NDELLKTVECFSLNTNKWSKGSplpishYGGCAIYHDGKIYV--I 443

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 504 NCTLYICDLSTYK-VYSFCPDTCVWKGEGSFECAGFNAGAIGIEDKIYILGGdYAPDEITDEVQVYHSSRSEWEEVSPMP 582
Cdd:PHA03098 444 GGISYIDNIKVYNiVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGG-DKYEYYINEIEVYDDKTNTWTLFCKFP 522

                        570
                 ....*....|...
gi 157822141 583 RALTEfyCQIIQF 595
Cdd:PHA03098 523 KVIGS--LEKNIF 533
 
Name Accession Description Interval E-value
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-153 4.60e-85

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 261.31  E-value: 4.60e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  24 FLASEDHGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFL 103
Cdd:cd18271    1 SLVAECHGQQILSVLQNFREQNAFFDFNIIVKDETIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTISNLSPKAVKAFL 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 157822141 104 DYAYTGKTRITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSISLVNCLHL 153
Cdd:cd18271   81 DYAYTGKAEITDDNVEMFFQMSSFLQVSLLSKACSDFLIKSIDLTNCLQL 130
PHA03098 PHA03098
kelch-like protein; Provisional
 38-595 2.58e-46

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 171.10  E-value: 2.58e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  38 LQSFREQNVFydfkIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDdgsVTItNLSSKAVKAFLDYAYTGKTRITDDN 117
Cdd:PHA03098   6 LQKFCDESII----IVNGGGIIKVHKIILSSSSEYFKKMFKNNFKENE---INL-NIDYDSFNEVIKYIYTGKINITSNN 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 118 VEMFFQLSSFLQVSFLSKACSDFLIKSISLVNCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKC 197
Cdd:PHA03098  78 VKDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKI 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 198 LESDELNVPEEEMVLKAVLTWIKYNVESRQKHLPHLIAKVRLHQLSEASLQDCLLNEEYLLKSTNCFETIVDAIKRVQG- 276
Cdd:PHA03098 158 LSDDKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLRITFLSEEGIKKLKRWKLRIKKKKIVFNKRCIKIIYSKKy 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 277 -SSGLFPDARPSTTEKYIfihKTEENGENQYTFCYNIKTDSWKILSQSHLIDLPGSSLssYGEKIFLTGGC--KGKCCRK 353
Cdd:PHA03098 238 nLNKILPRSSTFGSIIYI---HITMSIFTYNYITNYSPLSEINTIIDIHYVYCFGSVV--LNNVIYFIGGMnkNNLSVNS 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 354 VrlhiaESYHDATdqtwcycpikNEFFFVSTMKTPRTMHTSVTALNRLFVIGGKTRGSqdikSLLDVESYDPLSKEWTSV 433
Cdd:PHA03098 313 V-----VSYDTKT----------KSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSI----SLNTVESWKPGESKWREE 373

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 434 SPLprgiYYPEASAC----QNVIYVLGSEVEiadaFNPSLDCFFKYNATTDQWSELV------AEFGQFFHATLIKAvpV 503
Cdd:PHA03098 374 PPL----IFPRYNPCvvnvNNLIYVIGGISK----NDELLKTVECFSLNTNKWSKGSplpishYGGCAIYHDGKIYV--I 443

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 504 NCTLYICDLSTYK-VYSFCPDTCVWKGEGSFECAGFNAGAIGIEDKIYILGGdYAPDEITDEVQVYHSSRSEWEEVSPMP 582
Cdd:PHA03098 444 GGISYIDNIKVYNiVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGG-DKYEYYINEIEVYDDKTNTWTLFCKFP 522

                        570
                 ....*....|...
gi 157822141 583 RALTEfyCQIIQF 595
Cdd:PHA03098 523 KVIGS--LEKNIF 533
BACK_KBTBD3 cd18480
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 145-226 1.48e-39

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350555 [Multi-domain]  Cd Length: 82  Bit Score: 139.38  E-value: 1.48e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 145 ISLVNCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTWIKYNVE 224
Cdd:cd18480    1 LDLSNCLQLLSFAESYGSTRLLDHALEFVMQHFSLLSQSQEFLELNFEVLEKILEADELNVPDEEAVLKAVLRWTKHDLE 80


                 ..
gi 157822141 225 SR 226
Cdd:cd18480   81 AR 82
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 150-251 8.23e-28

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 107.25  E-value: 8.23e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  150 CLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTWIKYNVESRQKH 229
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|..
gi 157822141  230 LPHLIAKVRLHQLSEASLQDCL 251
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLV 102
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 150-250 6.67e-27

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 104.73  E-value: 6.67e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141   150 CLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTWIKYNVESRQKH 229
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|.
gi 157822141   230 LPHLIAKVRLHQLSEASLQDC 250
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLEV 101
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 38-145 5.46e-26

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 102.34  E-value: 5.46e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141   38 LQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTrITDDN 117
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL-ISEEN 79

                          90       100
                  ....*....|....*....|....*...
gi 157822141  118 VEMFFQLSSFLQVSFLSKACSDFLIKSI 145
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 49-145 6.41e-23

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 93.52  E-value: 6.41e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141    49 DFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTRITDDNVEMFFQLSSFL 128
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*..
gi 157822141   129 QVSFLSKACSDFLIKSI 145
Cdd:smart00225  81 QIPGLVELCEEFLLKLL 97
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
336-584 5.62e-21

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 93.30  E-value: 5.62e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 336 YGEKIFLTGGCKGKccrkvrlhiaesyhDATDQTWCYCPIKNEFFFVSTMKTPRTMHTSVTALN-RLFVIGGKTRGSQDI 414
Cdd:COG3055   21 LDGKVYVAGGLSGG--------------SASNSFEVYDPATNTWSELAPLPGPPRHHAAAVAQDgKLYVFGGFTGANPSS 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 415 KSLLDVESYDPLSKEWTSVSPLPRGIYYPEASACQNVIYVLGSeveIADAFNPSLdcFFKYNATTDQWSEL-VAEFGQFF 493
Cdd:COG3055   87 TPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGG---WDDGGNVAW--VEVYDPATGTWTQLaPLPTPRDH 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 494 HATlikAVPVNCTLYICDLSTYKVYSFcpdtcVWKGEGSFECAGFNAGAIGIEDKIYILGGDYApdeITDEVQVYHSSRS 573
Cdd:COG3055  162 LAA---AVLPDGKILVIGGRNGSGFSN-----TWTTLAPLPTARAGHAAAVLGGKILVFGGESG---FSDEVEAYDPATN 230

                        250
                 ....*....|.
gi 157822141 574 EWEEVSPMPRA 584
Cdd:COG3055  231 TWTALGELPTP 241
 
Name Accession Description Interval E-value
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-153 4.60e-85

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 261.31  E-value: 4.60e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  24 FLASEDHGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFL 103
Cdd:cd18271    1 SLVAECHGQQILSVLQNFREQNAFFDFNIIVKDETIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTISNLSPKAVKAFL 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 157822141 104 DYAYTGKTRITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSISLVNCLHL 153
Cdd:cd18271   81 DYAYTGKAEITDDNVEMFFQMSSFLQVSLLSKACSDFLIKSIDLTNCLQL 130
PHA03098 PHA03098
kelch-like protein; Provisional
 38-595 2.58e-46

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 171.10  E-value: 2.58e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  38 LQSFREQNVFydfkIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDdgsVTItNLSSKAVKAFLDYAYTGKTRITDDN 117
Cdd:PHA03098   6 LQKFCDESII----IVNGGGIIKVHKIILSSSSEYFKKMFKNNFKENE---INL-NIDYDSFNEVIKYIYTGKINITSNN 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 118 VEMFFQLSSFLQVSFLSKACSDFLIKSISLVNCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKC 197
Cdd:PHA03098  78 VKDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKI 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 198 LESDELNVPEEEMVLKAVLTWIKYNVESRQKHLPHLIAKVRLHQLSEASLQDCLLNEEYLLKSTNCFETIVDAIKRVQG- 276
Cdd:PHA03098 158 LSDDKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLRITFLSEEGIKKLKRWKLRIKKKKIVFNKRCIKIIYSKKy 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 277 -SSGLFPDARPSTTEKYIfihKTEENGENQYTFCYNIKTDSWKILSQSHLIDLPGSSLssYGEKIFLTGGC--KGKCCRK 353
Cdd:PHA03098 238 nLNKILPRSSTFGSIIYI---HITMSIFTYNYITNYSPLSEINTIIDIHYVYCFGSVV--LNNVIYFIGGMnkNNLSVNS 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 354 VrlhiaESYHDATdqtwcycpikNEFFFVSTMKTPRTMHTSVTALNRLFVIGGKTRGSqdikSLLDVESYDPLSKEWTSV 433
Cdd:PHA03098 313 V-----VSYDTKT----------KSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSI----SLNTVESWKPGESKWREE 373

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 434 SPLprgiYYPEASAC----QNVIYVLGSEVEiadaFNPSLDCFFKYNATTDQWSELV------AEFGQFFHATLIKAvpV 503
Cdd:PHA03098 374 PPL----IFPRYNPCvvnvNNLIYVIGGISK----NDELLKTVECFSLNTNKWSKGSplpishYGGCAIYHDGKIYV--I 443

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 504 NCTLYICDLSTYK-VYSFCPDTCVWKGEGSFECAGFNAGAIGIEDKIYILGGdYAPDEITDEVQVYHSSRSEWEEVSPMP 582
Cdd:PHA03098 444 GGISYIDNIKVYNiVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGG-DKYEYYINEIEVYDDKTNTWTLFCKFP 522

                        570
                 ....*....|...
gi 157822141 583 RALTEfyCQIIQF 595
Cdd:PHA03098 523 KVIGS--LEKNIF 533
BACK_KBTBD3 cd18480
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 145-226 1.48e-39

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350555 [Multi-domain]  Cd Length: 82  Bit Score: 139.38  E-value: 1.48e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 145 ISLVNCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTWIKYNVE 224
Cdd:cd18480    1 LDLSNCLQLLSFAESYGSTRLLDHALEFVMQHFSLLSQSQEFLELNFEVLEKILEADELNVPDEEAVLKAVLRWTKHDLE 80


                 ..
gi 157822141 225 SR 226
Cdd:cd18480   81 AR 82
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 150-251 8.23e-28

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 107.25  E-value: 8.23e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  150 CLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTWIKYNVESRQKH 229
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|..
gi 157822141  230 LPHLIAKVRLHQLSEASLQDCL 251
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLV 102
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-150 3.47e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 106.46  E-value: 3.47e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  30 HGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTG 109
Cdd:cd18253    1 HSESILQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEINGILAEAMDCFLQYVYTG 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 157822141 110 KTRITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSISLVNC 150
Cdd:cd18253   81 KVKITTENVQYLFETSSLFQISPLRDACAKFLEEQLDPCNC 121
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-151 3.91e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 106.39  E-value: 3.91e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  30 HGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTG 109
Cdd:cd18265    6 HAERILQVLNAYRRSGTFTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAAMEVLLDYMYGG 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 157822141 110 KTRITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSISLVNCL 151
Cdd:cd18265   86 GLRIQEDNVESVLEASDLLQVSKLREACVRFLEGQLHPCNCL 127
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 35-151 5.18e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 105.83  E-value: 5.18e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  35 LSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTRIT 114
Cdd:cd18238    3 FKVLHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDIDEEAVELLVDFAYTGKLTLT 82

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 157822141 115 DDNVEMFFQLSSFLQVSFLSKACSDFLIKSISLVNCL 151
Cdd:cd18238   83 VDNVQSLLYAASLLQVEEVAKACCEFMKDHLHPSNCL 119
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 150-250 6.67e-27

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 104.73  E-value: 6.67e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141   150 CLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTWIKYNVESRQKH 229
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|.
gi 157822141   230 LPHLIAKVRLHQLSEASLQDC 250
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLEV 101
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 47-128 1.05e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 103.40  E-value: 1.05e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  47 FYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTRITDDNVEMFFQLSS 126
Cdd:cd18186    1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAAD 80


                 ..
gi 157822141 127 FL 128
Cdd:cd18186   81 KL 82
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 38-145 5.46e-26

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 102.34  E-value: 5.46e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141   38 LQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTrITDDN 117
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL-ISEEN 79

                          90       100
                  ....*....|....*....|....*...
gi 157822141  118 VEMFFQLSSFLQVSFLSKACSDFLIKSI 145
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-150 6.33e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 99.78  E-value: 6.33e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  30 HGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTG 109
Cdd:cd18255    1 HSVTLLQGLNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGVSAKGLKHILDFAYTS 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 157822141 110 KTRITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSISLVNC 150
Cdd:cd18255   81 ELTLDLDCIQDVLGAAVHLQMLPVVELCEEFLKSAMSVENC 121
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-154 1.47e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 99.31  E-value: 1.47e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  29 DHGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYT 108
Cdd:cd18270    8 EYAVSLLEQLKFFYEQQLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQIIITYAYT 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 157822141 109 GKTRITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSISLVNCLHLL 154
Cdd:cd18270   88 GNLAINDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCVRLL 133
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-150 1.86e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 98.67  E-value: 1.86e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  27 SEDHGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYA 106
Cdd:cd18242    1 TNSHAKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEVELQGLTASTMEILLDFV 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 157822141 107 YTGKTRITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSISLVNC 150
Cdd:cd18242   81 YTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNC 124
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-154 1.01e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 97.20  E-value: 1.01e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  25 LASEDHGQKILSVLQSFREQNVFYDFKI--------IMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSS 96
Cdd:cd18273    4 LEDAAHARALLAQLKSFYDARLLTDVTIevngpgsgPGSGRLFPCNRNVLAAASPYFKSMFTGGLYESKQETVTIHDVDS 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 157822141  97 KAVKAFLDYAYTGKTRITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSISLVNCLHLL 154
Cdd:cd18273   84 ESMALIIDYCYTGRVTLSEANVQRLYAAANMLQLEYVREACASFLARRLDLSNCVGIL 141
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-141 2.23e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 95.57  E-value: 2.23e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  28 EDHGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAY 107
Cdd:cd18235    2 PQHTQKAFDVMNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQDVDGKALLLLIDYVY 81

                         90       100       110
                 ....*....|....*....|....*....|....
gi 157822141 108 TGKTRITDDNVEMFFQLSSFLQVSFLSKACSDFL 141
Cdd:cd18235   82 TAEIQVTEENVQVLLPAANLLQLTDVRDACCDFL 115
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-151 5.60e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 94.90  E-value: 5.60e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  30 HGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTG 109
Cdd:cd18259   15 HPQSILDGLQTLRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVESISARVEIKDVDPAVMESLIDFAYTG 94

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 157822141 110 KTRITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSISLVNCL 151
Cdd:cd18259   95 KLTINQGNVEALIRTSNRLQFPTVRKVCSRYLQQQIDATNCL 136
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 49-145 6.41e-23

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 93.52  E-value: 6.41e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141    49 DFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTRITDDNVEMFFQLSSFL 128
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*..
gi 157822141   129 QVSFLSKACSDFLIKSI 145
Cdd:smart00225  81 QIPGLVELCEEFLLKLL 97
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-143 7.83e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 93.88  E-value: 7.83e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  33 KILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTR 112
Cdd:cd18247    5 SGFPVMEEIRRQGKLCDVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQGIEPSALEALINFAYSGRIA 84

                         90       100       110
                 ....*....|....*....|....*....|.
gi 157822141 113 ITDDNVEMFFQLSSFLQVSFLSKACSDFLIK 143
Cdd:cd18247   85 IDTSNVQSLLVGASFLQLQSVKDACCEFLKE 115
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-153 3.47e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 93.13  E-value: 3.47e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  30 HGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITN-LSSKAVKAFLDYAYT 108
Cdd:cd18267   23 YADSVLTHLNLLRQQRLFTDVLLHAGNRSFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFHDsIHPEVLELLLDYAYS 102

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 157822141 109 GKTRITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSISLVNCLHL 153
Cdd:cd18267  103 SRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGM 147
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-151 5.07e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 91.81  E-value: 5.07e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  29 DHGQKILSVLQSFREQNVFYDFKIIMKE-EIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAY 107
Cdd:cd18252    3 SHPADFLDAFRTFYLDGLFTDITLQCASgQIFHCHKAALAACSSYFKVMFTADMKEKSNNVIKLSGIDHDILEALVNYVY 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 157822141 108 TGKTRITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSISLVNCL 151
Cdd:cd18252   83 TSQICITERNVQSLLEAADLLQFISVKKACEQFLVRHLDIDNCL 126
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-151 9.02e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 91.01  E-value: 9.02e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  34 ILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTRI 113
Cdd:cd18237    8 FMGVMNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPDIIELLVEFAYTARISV 87

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 157822141 114 TDDNVEMFFQLSSFLQVSFLSKACSDFLIKSISLVNCL 151
Cdd:cd18237   88 NSNNVQSLLDAANQYQIEPVKKMCVDFLKEQLDASNCL 125
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-151 2.12e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 90.16  E-value: 2.12e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  30 HGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTG 109
Cdd:cd18256    3 HASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHILLDFIYTG 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 157822141 110 KTRITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSISLVNCL 151
Cdd:cd18256   83 VVEVTVSNVQELLVAADMLQLTEVVEICCEFLKGQLHPSNCI 124
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-151 3.77e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 89.46  E-value: 3.77e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  28 EDHGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAY 107
Cdd:cd18268    4 QDLSSELLRQLNSLRQERILTDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLKGIDSDVLDQIVDYVY 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 157822141 108 TGKTRITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSISLVNCL 151
Cdd:cd18268   84 TGEILITRDNVLPLMEAASMLQYPKLFEACSLYLQDQLTPENCL 127
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
336-584 5.62e-21

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 93.30  E-value: 5.62e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 336 YGEKIFLTGGCKGKccrkvrlhiaesyhDATDQTWCYCPIKNEFFFVSTMKTPRTMHTSVTALN-RLFVIGGKTRGSQDI 414
Cdd:COG3055   21 LDGKVYVAGGLSGG--------------SASNSFEVYDPATNTWSELAPLPGPPRHHAAAVAQDgKLYVFGGFTGANPSS 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 415 KSLLDVESYDPLSKEWTSVSPLPRGIYYPEASACQNVIYVLGSeveIADAFNPSLdcFFKYNATTDQWSEL-VAEFGQFF 493
Cdd:COG3055   87 TPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGG---WDDGGNVAW--VEVYDPATGTWTQLaPLPTPRDH 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 494 HATlikAVPVNCTLYICDLSTYKVYSFcpdtcVWKGEGSFECAGFNAGAIGIEDKIYILGGDYApdeITDEVQVYHSSRS 573
Cdd:COG3055  162 LAA---AVLPDGKILVIGGRNGSGFSN-----TWTTLAPLPTARAGHAAAVLGGKILVFGGESG---FSDEVEAYDPATN 230

                        250
                 ....*....|.
gi 157822141 574 EWEEVSPMPRA 584
Cdd:COG3055  231 TWTALGELPTP 241
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-145 1.33e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 87.82  E-value: 1.33e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  30 HGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTG 109
Cdd:cd18338    4 HMKKAFKVMNELRSQNLLCDVTIVAEDVEIAAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLKMLIDYVYTA 83

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 157822141 110 KTRITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSI 145
Cdd:cd18338   84 EIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQL 119
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-150 1.53e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 87.52  E-value: 1.53e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  30 HGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTG 109
Cdd:cd18250    4 HALHLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRADRVVLHGVSAEILGLLLDFSYTG 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 157822141 110 KTRITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSISLVNC 150
Cdd:cd18250   84 RVTVTQDNVEALLRAADLFQFPSVKEACCAYLQQRLDVSNC 124
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
308-568 1.80e-20

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 91.76  E-value: 1.80e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 308 FCYNIKTDSWKILSqshliDLPGSSLS-----SYGEKIFLTGGCKGKccrkvrlhiaESYHDATDQTWCYCPIKNEFFFV 382
Cdd:COG3055   41 EVYDPATNTWSELA-----PLPGPPRHhaaavAQDGKLYVFGGFTGA----------NPSSTPLNDVYVYDPATNTWTKL 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 383 STMKTPRTMHTSVTALNRLFVIGGktrgSQDIKSLLDVESYDPLSKEWTSVSPLPRGIYYPEA-SACQNVIYVLGSevei 461
Cdd:COG3055  106 APMPTPRGGATALLLDGKIYVVGG----WDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAaVLPDGKILVIGG---- 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 462 adafnpsldcfFKYNATTDQWSELVAEFGQFFHATlikAVPVNCTLYICDLSTY---KVYSFCPDTCVWKGEGSFECAGF 538
Cdd:COG3055  178 -----------RNGSGFSNTWTTLAPLPTARAGHA---AAVLGGKILVFGGESGfsdEVEAYDPATNTWTALGELPTPRH 243

                        250       260       270
                 ....*....|....*....|....*....|
gi 157822141 539 NAGAIGIEDKIYILGGDYAPDEITDEVQVY 568
Cdd:COG3055  244 GHAAVLTDGKVYVIGGETKPGVRTPLVTSA 273
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-141 3.05e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 86.44  E-value: 3.05e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  30 HGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTG 109
Cdd:cd18257    1 HSEQLLQGLNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNLSEKENSEVEFQCIDETALQAIVEYAYTG 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 157822141 110 KTRITDDNVEMFFQLSSFLQVSFLSKACSDFL 141
Cdd:cd18257   81 TVFISQATVESLLPAANLLQIKLVLKECCDFL 112
BACK_KLHL1_like cd18444
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...
 149-249 3.15e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.


Pssm-ID: 350519 [Multi-domain]  Cd Length: 106  Bit Score: 85.85  E-value: 3.15e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 149 NCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTWIKYNVESRQK 228
Cdd:cd18444    6 NCLGIRSFADAQGCTDLLKVAHNYTMEHFMEVIQNQEFLLLPAEEVAKLLASDDLNVPSEETIFHALLLWVKHDLPERKK 85

                         90       100
                 ....*....|....*....|.
gi 157822141 229 HLPHLIAKVRLHQLSEASLQD 249
Cdd:cd18444   86 HLAKLLALIRLPLLTPQFLAD 106
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 49-151 3.42e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 85.88  E-value: 3.42e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  49 DFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTRITDDNVEMFFQLSSFL 128
Cdd:cd18234    3 DVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVREATEEEIKLKDVDPDALWTLVQYCYTGRLELKEDNVESLLATACLL 82

                         90       100
                 ....*....|....*....|...
gi 157822141 129 QVSFLSKACSDFLIKSISLVNCL 151
Cdd:cd18234   83 QLSEVVEACCGFLMKQLHPSNCL 105
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-141 9.14e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 85.16  E-value: 9.14e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  30 HGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTG 109
Cdd:cd18339    4 HMKKAFKVMNELRSKQLLCDVTIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDYIYTA 83

                         90       100       110
                 ....*....|....*....|....*....|..
gi 157822141 110 KTRITDDNVEMFFQLSSFLQVSFLSKACSDFL 141
Cdd:cd18339   84 EIEVTEENVQVLLPAASLLQLMDVRQNCCDFL 115
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-151 1.27e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 85.06  E-value: 1.27e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  30 HGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTI-TNLSSKAVKAFLDYAYT 108
Cdd:cd18254    5 HPDCVLTHLNTLRKQCMFTDVTLWAGNRSFPCHRAVLAACSRYFEAMFSNGLRESLDSTVNFhDSLHPEVLELLLDFAYS 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 157822141 109 GKTRITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSISLVNCL 151
Cdd:cd18254   85 SRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCL 127
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-151 2.81e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 84.25  E-value: 2.81e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  27 SEDHGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYA 106
Cdd:cd18261    8 SKSHKDAVLAALNQQRNDGILCDITLVAEEQKFHAHKAVLAACSDYFRAMFSLCMVESEADEVNLHGVTSLGLKQALDFA 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 157822141 107 YTGKTRITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSISLVNCL 151
Cdd:cd18261   88 YTGQILLEPGVIQDVLAAGSHLQLLELLSLCSHYLIQELNSFNYL 132
BACK_KLHL2_Mayven cd18512
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...
 148-272 3.16e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.


Pssm-ID: 350587 [Multi-domain]  Cd Length: 130  Bit Score: 83.93  E-value: 3.16e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 148 VNCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLemNFGVLQKC--LESDELNVPEEEMVLKAVLTWIKYNVES 225
Cdd:cd18512    4 TNCLGIRAFADMHACTELLNQANTYAEQHFSDVVLSEEFL--NLGIEQVCslIASDKLTISSEEKVFEAVIAWVNHDKEV 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 157822141 226 RQKHLPHLIAKVRLHQLSEASLQDcLLNEEYLLKSTN-CFETIVDAIK 272
Cdd:cd18512   82 RQEHMAHLMEHVRLPLLSREYLVQ-RVEEETLVKNSSaCKDYLIEAMK 128
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-151 6.34e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 83.17  E-value: 6.34e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  29 DHGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYT 108
Cdd:cd18336    1 NHAEQTFRKMENYLQHKQLCDVLLIAGNLKIPAHRLVLSAVSDYFAAMFTNDVREAKQEEIKMEGVDPDALKALVHYAYT 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 157822141 109 GKTRITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSISLVNCL 151
Cdd:cd18336   81 GVLELKEDTIESLLAAACLLQLSQVIDVCCNFLMKQLHPSNCL 123
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 38-151 8.50e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 82.96  E-value: 8.50e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  38 LQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTRITDDN 117
Cdd:cd18340   18 LKDLLDHNKFVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDLEESKKREIVLEDVDPDVMGKILHYIYTSEIEITEQN 97

                         90       100       110
                 ....*....|....*....|....*....|....
gi 157822141 118 VEMFFQLSSFLQVSFLSKACSDFLIKSISLVNCL 151
Cdd:cd18340   98 VQDIFAAANMFQIPSIFTVCVSFLQKRLCLSNCL 131
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-151 1.18e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 82.11  E-value: 1.18e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  27 SEDHGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYA 106
Cdd:cd18249    3 SDKHPRQTLEAINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVTIRDIDERAMELLIDFA 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 157822141 107 YTGKTRITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSISLVNCL 151
Cdd:cd18249   83 YTSQITVEEGNVQTLLPAACLLQLAEIQEVCCEFLKRQLDPSNCL 127
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-153 1.22e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 81.92  E-value: 1.22e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  30 HGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFramFEVNMKERDDGS---VTITNLSSKAVKAFLDYA 106
Cdd:cd18306    1 HPESVLAKLNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYL---FELFSSDSDGESiltVKLDGLDPDAVEVLVNYA 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 157822141 107 YTGKTRITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSISLVNCLHL 153
Cdd:cd18306   78 YTSRLEVPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNCIGI 124
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 60-150 1.45e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 81.60  E-value: 1.45e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  60 PCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTRITDDNVEMFFQLSSFLQVSFLSKACSD 139
Cdd:cd18240   30 PAHRNILCACSPYFRALFTNGWNETEKKVYKIPGVSPEMMELIIEYAYTRTVPITAENVEELLPAADQFNIMGIVKACCD 109

                         90
                 ....*....|.
gi 157822141 140 FLIKSISLVNC 150
Cdd:cd18240  110 FLEDQLCPENC 120
BACK_KLHL5 cd18511
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...
 149-249 1.67e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.


Pssm-ID: 350586 [Multi-domain]  Cd Length: 106  Bit Score: 81.27  E-value: 1.67e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 149 NCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTWIKYNVESRQK 228
Cdd:cd18511    6 NCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFLLLPASEIAKLLASDDMNIPNEETILNALLSWVRHDVEQRRK 85

                         90       100
                 ....*....|....*....|.
gi 157822141 229 HLPHLIAKVRLHQLSEASLQD 249
Cdd:cd18511   86 DLSKLLAYIRLPLLAPQFLAD 106
PHA02790 PHA02790
Kelch-like protein; Provisional
 65-460 1.96e-18

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 88.56  E-value: 1.96e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  65 VLAACSDFFRA-MFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTRITDDNVEMFFQLSSFLQVSFLSKACSDFLIK 143
Cdd:PHA02790  39 ILKKLSPYFRThLRQKYTKNKDPVTRVCLDLDIHSLTSIVIYSYTGKVYIDSHNVVNLLRASILTSVEFIIYTCINFILR 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 144 SISLVNCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLL----FKSRDFLEMNFgvlqkCLESDELNVPEEEMVLKAVLTWI 219
Cdd:PHA02790 119 DFRKEYCVECYMMGIEYGLSNLLCHTKDFIAKHFLELeddiIDNFDYLSMKL-----ILESDELNVPDEDYVVDFVIKWY 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 220 KYNvESRQKHLPHLIAKV-RLHQLSEASLQdcllNEEYLLKSTNCFETivdaikrvqgssglfpDARPSTTEKYIFIhkt 298
Cdd:PHA02790 194 MKR-RNRLGNLLLLIKNViRSNYLSPRGIN----NVKWILDCTKIFHC----------------DKQPRKSYKYPFI--- 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 299 eengenQYTFCYNIKTDSWKILSQSHLidlpgsslssyGEKIFLTGGCkgkccrkvrlhIAESYHDATDQTWCycpIKNE 378
Cdd:PHA02790 250 ------EYPMNMDQIIDIFHMCTSTHV-----------GEVVYLIGGW-----------MNNEIHNNAIAVNY---ISNN 298

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 379 FFFVSTMKTPRTMHTSVTALNRLFVIGGktrgsqdIKSLLDVESYDPLSKEWTSVSPLPRGIYYPEASACQNVIYVLGSE 458
Cdd:PHA02790 299 WIPIPPMNSPRLYASGVPANNKLYVVGG-------LPNPTSVERWFHGDAAWVNMPSLLKPRCNPAVASINNVIYVIGGH 371


                 ..
gi 157822141 459 VE 460
Cdd:PHA02790 372 SE 373
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-150 2.34e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 81.39  E-value: 2.34e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  27 SEDHGQKILSVLQSFREQNVFYDFKIIMKE--EIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLD 104
Cdd:cd18239    3 SNTHSSVVLQGFDQLRGEGLLCDVTLVPGDgdETFPVHRAMMASASDYFKAMFTGGMKEQELMCIKLHGVSKIGLKNIID 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 157822141 105 YAYTGKTRITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSISLVNC 150
Cdd:cd18239   83 FIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVLLISGVTLENC 128
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 38-150 3.06e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 81.05  E-value: 3.06e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  38 LQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTRITDDN 117
Cdd:cd18236   15 LENLRLENSLTDVILCVDSQEFSCHRVVLAAASNYFRAMFCNDLKEKYEEKIIIKGVDAETMQILLDYTYTSKVLITKQN 94

                         90       100       110
                 ....*....|....*....|....*....|...
gi 157822141 118 VEMFFQLSSFLQVSFLSKACSDFLIKSISLVNC 150
Cdd:cd18236   95 VQRVLEAASLFQFLRMVDACASFLTEALHPENC 127
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-150 7.11e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 80.23  E-value: 7.11e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  24 FLA-SEDHGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAF 102
Cdd:cd18264    4 FLAySKSHGEAVLSQYQSLRAEGFLCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDYTQESKARVIHLPVVSAAGLQRV 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 157822141 103 LDYAYTGKTRITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSISLVNC 150
Cdd:cd18264   84 LDFIYTSWLSLSLDTLEDTLEAASYLQVTEAIGLCSQYLINNLAPENC 131
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 38-151 1.01e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 79.76  E-value: 1.01e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  38 LQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTRITDDN 117
Cdd:cd18269   18 LKDLLDENKFVDCVLKIGDKEFPCHRLVLAACSPYFRAMFLSDLEESKKKEVVLEDVDPDVMGMILKYLYTSEIDLNDQN 97

                         90       100       110
                 ....*....|....*....|....*....|....
gi 157822141 118 VEMFFQLSSFLQVSFLSKACSDFLIKSISLVNCL 151
Cdd:cd18269   98 VQDIFALASRFQIPSIFTVCVSYLQKRLSLSNCL 131
BACK_KLHL12 cd18452
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...
 149-285 1.61e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.


Pssm-ID: 350527 [Multi-domain]  Cd Length: 136  Bit Score: 79.36  E-value: 1.61e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 149 NCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTWIKYNVESRQK 228
Cdd:cd18452    5 NCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNWVKHDKEERED 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 157822141 229 HLPHLIAKVRLHQLSEASLQDCLLNEEYLLKSTNCfETIVDAIKRVQgssgLFPDAR 285
Cdd:cd18452   85 YLPELLQYVRLPLLSPRYITDVVDAEPLIRCSLEC-RDLVDEAKKFH----LRPELR 136
BACK_KLHL18 cd18457
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...
 149-249 2.04e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.


Pssm-ID: 350532 [Multi-domain]  Cd Length: 107  Bit Score: 78.12  E-value: 2.04e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 149 NCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTWIKYNVESRQK 228
Cdd:cd18457    5 NCLGIRQFAETMMCSSLVDAANKYIQQHFIEVSKSEEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVKYDRENREE 84

                         90       100
                 ....*....|....*....|.
gi 157822141 229 HLPHLIAKVRLHQLSEASLQD 249
Cdd:cd18457   85 YLPELLSKVRLPLLRPQFLTD 105
BACK_KLHL3 cd18513
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...
 149-272 2.77e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.


Pssm-ID: 350588 [Multi-domain]  Cd Length: 130  Bit Score: 78.57  E-value: 2.77e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 149 NCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTWIKYNVESRQK 228
Cdd:cd18513    5 NCLGIRAFADVHTCTELLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWIKYDKEARLE 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 157822141 229 HLPHLIAKVRLHQLSEASLQDcLLNEEYLLKSTN-CFETIVDAIK 272
Cdd:cd18513   85 HMAKLMEHVRLPLLPRDYLVQ-TVEEEALIKNNNtCKDFLIEAMK 128
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-157 4.21e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 78.01  E-value: 4.21e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  28 EDHGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAY 107
Cdd:cd18266    6 ADHSNLVLQGLNEQRQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAHQKEVELVGASYIGLKAVIDFLY 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 157822141 108 TGKTRITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSISLVNCLHLLSLS 157
Cdd:cd18266   86 SSELPLDGGNIDYVLETAHLLQIWKVVDFCCEYLENEVSEENYLYLQELA 135
BACK_KLHL2_like cd18445
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...
 149-259 5.33e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.


Pssm-ID: 350520 [Multi-domain]  Cd Length: 114  Bit Score: 76.89  E-value: 5.33e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 149 NCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTWIKYNVESRQK 228
Cdd:cd18445    5 NCLGIRAFADLHSCTDLLKYAQTYTEQHFSEVVKGEEFLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDPENRKE 84

                         90       100       110
                 ....*....|....*....|....*....|.
gi 157822141 229 HLPHLIAKVRLHQLSEASLQDCLLNEEyLLK 259
Cdd:cd18445   85 HLAELLEHVRLPLLSPEYLVQRVEEEE-LIK 114
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-141 9.27e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 76.22  E-value: 9.27e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  34 ILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTIT--NLSSKAVKAFLDYAYTGKT 111
Cdd:cd18245    1 LLRALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPPKDDGSTYKIEleGISVEVMEEILDYIYTGQI 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 157822141 112 RITDDNVEMFFQLSSFLQVSFLSKACSDFL 141
Cdd:cd18245   81 KLSEDNIQDIVQAADLLLMTDLKDLCCEFL 110
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-151 1.12e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 76.56  E-value: 1.12e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  61 CHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTRITDDNVEMFFQLSSFLQVSFLSKACSDF 140
Cdd:cd18274   37 CHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMHLVLDYAYTSRVTLTEANVQALFTAASIFQIPSLQDQCAQF 116

                         90
                 ....*....|.
gi 157822141 141 LIKSISLVNCL 151
Cdd:cd18274  117 MISRLDPQNSI 127
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-152 3.28e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 74.85  E-value: 3.28e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  30 HGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEvnmKERDDGSVTITNLSSKAVKAFLDYAYTG 109
Cdd:cd18260    1 YGANLLEGLNRMRQERFLCDLTIATKTKSFDVHKVVMASCSEYFRNILK---KDPSLQRVELNDISPLGLATVITYAYTG 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 157822141 110 KTRITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSISLVNCLH 152
Cdd:cd18260   78 KLTLSLYTIGSTISAASYLQIHALVKMCCDFLMQEMNVENCMY 120
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-145 3.65e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 75.28  E-value: 3.65e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  30 HGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERD----DGSVTITNLSSKAVKAF--- 102
Cdd:cd18228    2 HSQELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVGQASPRLvlvsPAGKCVLDLHHVTVTGFapl 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 157822141 103 LDYAYTGKTRITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSI 145
Cdd:cd18228   82 LEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFMKSSI 124
BACK_KLHL20 cd18459
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...
 149-243 7.48e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.


Pssm-ID: 350534 [Multi-domain]  Cd Length: 100  Bit Score: 73.23  E-value: 7.48e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 149 NCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTWIKYNVESRQK 228
Cdd:cd18459    6 NCLGIRAFADTHACRELLRIADKFTQHNFQEVMESEEFMLLPVNQLIDIISSDELNVRSEEQVFNAVMAWVKYNIQERRP 85

                         90
                 ....*....|....*
gi 157822141 229 HLPHLIAKVRLHQLS 243
Cdd:cd18459   86 HLPQVLQHVRLPLLS 100
BACK_KLHL25_like cd18464
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The ...
 149-239 9.22e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The family includes KLHL25 and KLHL37. KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350539 [Multi-domain]  Cd Length: 98  Bit Score: 72.92  E-value: 9.22e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 149 NCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTWIKYNVESRQK 228
Cdd:cd18464    4 NCLGMLLLSDAHQCQRLYELSWRMCLANFTTLRKTEDFLSLPKDKLLELVSSEELEVEDERLVYEAVIGWIRYDLPRRHE 83

                         90
                 ....*....|.
gi 157822141 229 HLPHLIAKVRL 239
Cdd:cd18464   84 VLPELLRSVRL 94
BACK_KBTBD2 cd18479
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 145-239 1.10e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.


Pssm-ID: 350554 [Multi-domain]  Cd Length: 96  Bit Score: 72.78  E-value: 1.10e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 145 ISLVNCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTWIKYNVE 224
Cdd:cd18479    1 INAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTE 80

                         90
                 ....*....|....*
gi 157822141 225 SRQKHLPHLIAKVRL 239
Cdd:cd18479   81 SRSQYLSSVLSQIRI 95
BTB_POZ_KLHL5 cd18337
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-151 1.28e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349646 [Multi-domain]  Cd Length: 130  Bit Score: 73.56  E-value: 1.28e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  29 DHGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYT 108
Cdd:cd18337    5 NHAEQTFKKMENYLRHKQLCDVVLVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREAKQEEIKMEGVEPNALWALVQYAYT 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 157822141 109 GKTRITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSISLVNCL 151
Cdd:cd18337   85 GRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCL 127
BACK_KLHL4 cd18510
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ...
 149-249 2.02e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350585 [Multi-domain]  Cd Length: 106  Bit Score: 72.26  E-value: 2.02e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 149 NCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTWIKYNVESRQK 228
Cdd:cd18510    6 NCLGIRSFGDAQGCTELLKVAHSYTMEHFLEVIKNQEFLLLPASEIVKLLASDDINVPDEETIFQALMMWVRHDLQNRQK 85

                         90       100
                 ....*....|....*....|.
gi 157822141 229 HLPHLIAKVRLHQLSEASLQD 249
Cdd:cd18510   86 DLGMLLSYIRLPLLPPQLLAD 106
BACK_KLHL8 cd18448
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...
 149-239 6.51e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.


Pssm-ID: 350523 [Multi-domain]  Cd Length: 97  Bit Score: 70.41  E-value: 6.51e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 149 NCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTWIKYNVESRQK 228
Cdd:cd18448    6 NCLGVRTFAEQHNRVDLMKMADKYACDHFNEVVECEEFVSISAQHLEKLISSSDLNVESESQVYEAVMKWVKHDPQHRKR 85

                         90
                 ....*....|.
gi 157822141 229 HLPHLIAKVRL 239
Cdd:cd18448   86 HLDDLLSQVRL 96
BACK_KLHL1 cd18509
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...
 149-249 7.25e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350584 [Multi-domain]  Cd Length: 106  Bit Score: 70.82  E-value: 7.25e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 149 NCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTWIKYNVESRQK 228
Cdd:cd18509    6 NCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQRRCS 85

                         90       100
                 ....*....|....*....|.
gi 157822141 229 HLPHLIAKVRLHQLSEASLQD 249
Cdd:cd18509   86 DLSMLLAYIRLPLLPPQLLAD 106
BACK_KLHL25_ENC2 cd18514
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...
 149-239 8.90e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).


Pssm-ID: 350589 [Multi-domain]  Cd Length: 99  Bit Score: 70.26  E-value: 8.90e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 149 NCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTWIKYNVESRQK 228
Cdd:cd18514    5 NCLGMMLLSDAHQCRRLYELSWRMCLVHFETVRESEDFYSLSKDKLLDLISSDELEIEDEQVVFNAVLQWVKYDLEKRKD 84

                         90
                 ....*....|.
gi 157822141 229 HLPHLIAKVRL 239
Cdd:cd18514   85 YLPELLRNVRL 95
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-143 9.23e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 70.87  E-value: 9.23e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  28 EDHGQKILSVLQSFREQNVFYDFKIIMK----EEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFL 103
Cdd:cd18248    2 EDHTKEAFQIMNELRLSQQLCDVTLKVKyqdpKEEFMAHKVVLASSSPYFKAMFTSGLRECGMEVVPIEGVHPCVMSRLI 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 157822141 104 DYAYTGKTRITDDNVEMFFQLSSFLQVSFLSKACSDFLIK 143
Cdd:cd18248   82 EFAYTASISVGEKCVLHVLPGAVMYQMDSVVKACCDFLEQ 121
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-142 1.75e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 70.23  E-value: 1.75e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  27 SEDHGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYA 106
Cdd:cd18251    3 SVAHSQALLDGLVALRDSGILFDVVLVVEGKPIEAHRILLAASCDYFRGMFAGGLREMQQTEVLIHGVSYNAMCKILDFI 82

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 157822141 107 YTGKTRITDDNVEMFFQLSSFLQVSFLSKACSDFLI 142
Cdd:cd18251   83 YTSELELSLDNVQETLTAACQLQIPEVIGFCCDFLM 118
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 38-151 2.19e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 70.26  E-value: 2.19e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  38 LQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTRITDDN 117
Cdd:cd18341   18 LKELLDENKFVDCTLKAGDKSLPCHRLILAACSPYFREYFLSEESEEKKKEVVLDNVDPNIMDMILKYLYSAEIDLNDGN 97

                         90       100       110
                 ....*....|....*....|....*....|....
gi 157822141 118 VEMFFQLSSFLQVSFLSKACSDFLIKSISLVNCL 151
Cdd:cd18341   98 VQDIFALASRFQIPSVFTVCVTYLQKRLSPANCL 131
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-154 3.68e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 69.60  E-value: 3.68e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  27 SEDHGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYA 106
Cdd:cd18244   10 SSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFM 89

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 157822141 107 YTGKTRITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSISLVNCLHLL 154
Cdd:cd18244   90 YYGTIELSMLTVHEILQAAMYVQLTEVVKFCCSFLLAKICLDNCAEIM 137
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-151 7.47e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 68.53  E-value: 7.47e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  30 HGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTG 109
Cdd:cd18335    2 HAEQTFRKMESYLKQQQLCDVILIAGNRKIPAHRLVLSAVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTG 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 157822141 110 KTRITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSISLVNCL 151
Cdd:cd18335   82 CLELKEDTIENLLAAACLLQLSQVVEVCCHFLMKLLHPSNCL 123
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-151 7.60e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 68.68  E-value: 7.60e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  30 HGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTG 109
Cdd:cd18276    4 HSLTLLDQLNRMKELAELTDVVLVAEGEKFPCHRLVLAAFSPYFKAMFTCGLMECSQREVVLHDITAESVSIILNYMYSS 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 157822141 110 KTRITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSISLVNCL 151
Cdd:cd18276   84 DLHLTNSNVQGVATAAFFLQMEDIFSVCQKYMMDHMDASNCL 125
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 47-132 9.27e-14

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 66.80  E-value: 9.27e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  47 FYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEvNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTRITDDNVEMFFQLSS 126
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLK-ETPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAE 79


                 ....*.
gi 157822141 127 FLQVSF 132
Cdd:cd18315   80 LLQIKG 85
BACK_KLHL17 cd18456
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...
 149-243 9.87e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.


Pssm-ID: 350531 [Multi-domain]  Cd Length: 102  Bit Score: 67.33  E-value: 9.87e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 149 NCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTWIKYNVESRQK 228
Cdd:cd18456    5 NCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSKTEEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVLSWVKHDVDGRRQ 84

                         90
                 ....*....|....*
gi 157822141 229 HLPHLIAKVRLHQLS 243
Cdd:cd18456   85 HVPRLMKCVRLPLLS 99
BACK_KLHL28_BTBD5 cd18467
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ...
 149-243 1.04e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.


Pssm-ID: 350542 [Multi-domain]  Cd Length: 99  Bit Score: 67.28  E-value: 1.04e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 149 NCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTWIKYNVESRQK 228
Cdd:cd18467    5 NCIGISRFAETYGCHDLYLAANKYICQNFEDVCQTEEFFELTHAELDEIVSNDCLNVVTEETVFYALESWIKYDVQERQK 84

                         90
                 ....*....|....*
gi 157822141 229 HLPHLIAKVRLHQLS 243
Cdd:cd18467   85 YLAQLLHCVRLPLLS 99
BACK_KLHL37_ENC1 cd18515
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...
 148-242 1.29e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350590 [Multi-domain]  Cd Length: 98  Bit Score: 66.92  E-value: 1.29e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 148 VNCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTWIKYNVESRQ 227
Cdd:cd18515    3 TNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTICKTEDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWVNYDLKKRH 82

                         90
                 ....*....|....*
gi 157822141 228 KHLPHLIAKVRLHQL 242
Cdd:cd18515   83 CYLSELLQTVRLALL 97
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 47-137 1.90e-13

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 66.21  E-value: 1.90e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  47 FYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTRITDDNVEMFFQLSS 126
Cdd:cd18314    6 FSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKEVTLEDVEPEIFETVLKYMYTGQVTLSEENVLDLLMLAS 85

                         90
                 ....*....|.
gi 157822141 127 FLQVSFLSKAC 137
Cdd:cd18314   86 KYQVPDLEKLC 96
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-141 2.21e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 66.81  E-value: 2.21e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  29 DHGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYT 108
Cdd:cd18198    7 DHSSEILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSPEALTALLEFAYT 86

                         90       100       110
                 ....*....|....*....|....*....|...
gi 157822141 109 GKTRITDDNVEMFFQLSSFLQVSFLSKACSDFL 141
Cdd:cd18198   87 ATLTVSTANVGDILSAARLLEIPCVSHVCAEIL 119
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-141 3.33e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 66.50  E-value: 3.33e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  29 DHGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYT 108
Cdd:cd18326    7 DHSSDILSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSAEALTALLDFAYT 86

                         90       100       110
                 ....*....|....*....|....*....|...
gi 157822141 109 GKTRITDDNVEMFFQLSSFLQVSFLSKACSDFL 141
Cdd:cd18326   87 ATLTVSTSNVGDILSAARLLEIPAVSHVCADLL 119
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-151 8.40e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 65.38  E-value: 8.40e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  32 QKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGS---VTITNLSSKAVKAFLDYAYT 108
Cdd:cd18258    2 KEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSSRDSGGGEkleLTMSNINADVLELLLEFVYT 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 157822141 109 GKTRITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSISLVNCL 151
Cdd:cd18258   82 GSLIIDSANAKTLLEAANKFQFHTFCKVCVSFLEKQLTASNCL 124
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-140 1.01e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 64.89  E-value: 1.01e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  30 HGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFevnmKERDDGSVTITNLS----SKAVKAFLDY 105
Cdd:cd18215    2 HASDVLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIF----TDQLKNNVSVINLDpeiePEGFRILLDF 77

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 157822141 106 AYTGKTRITDDNVEMFFQLSSFLQVSFLSKACSDF 140
Cdd:cd18215   78 MYTSRLNLREGNIMAVMATAMYLQMEHVVDTCRKF 112
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-145 1.64e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 65.05  E-value: 1.64e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  27 SEDHGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYA 106
Cdd:cd18246   19 SKRHYHDAFVSMNRMRQRGLLCDIVLHVGTKEIKAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALEQLVQYA 98

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 157822141 107 YTGKTRITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSI 145
Cdd:cd18246   99 YTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQL 137
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-154 1.78e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 64.92  E-value: 1.78e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  36 SVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTRITD 115
Cdd:cd18272   21 SIMDLCLEDGLFADVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKDVSESVFQLLVDYIYHGTVKLRV 100

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 157822141 116 DNVEMFFQLSSFLQVSFLSKACSDFLIKSISLVNCLHLL 154
Cdd:cd18272  101 EELQETYEVADMYQLTALFEECSRFLARTVQVRNCLQVM 139
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 47-141 3.17e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 63.41  E-value: 3.17e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  47 FYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGK---TRITDDNVEMFFQ 123
Cdd:cd18287   22 YSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQQSEIELKDTNAEAFKALLKYIYTGRltlTDLKEDVLLDVLG 101

                         90       100
                 ....*....|....*....|.
gi 157822141 124 LS---SFLQvsfLSKACSDFL 141
Cdd:cd18287  102 LAhqyGFEE---LEAAISDYL 119
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 38-151 5.27e-12

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 62.91  E-value: 5.27e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  38 LQSFR---EQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTRIT 114
Cdd:cd18263    1 LQSIEglwEKGVGCDVQLEADGSIFRVHRVILAAGSDYFRAMFTSGMKESTQSVVQLPTIPAKDLRLLISFAYSGILHLS 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 157822141 115 DDNVEMFFQLSSFLQVSFLSKACSDFLIKSISLVNCL 151
Cdd:cd18263   81 WENLFEATCTALQLQISGALALCLDFLQREISPARCL 117
BACK_KLHL30 cd18469
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...
 149-244 5.53e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.


Pssm-ID: 350544 [Multi-domain]  Cd Length: 104  Bit Score: 62.47  E-value: 5.53e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 149 NCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTWIKYNVESRQK 228
Cdd:cd18469    7 NCLGICEFGETHGCPEVAAKAWSFLLENFEAVSQEEEFLQLEKERLVACLGDDLLQVRDEQSRLEAVLRWVGHDPQARAA 86

                         90
                 ....*....|....*.
gi 157822141 229 HLPHLIAKVRLHQLSE 244
Cdd:cd18469   87 HLPELLSLVHLSLLTD 102
BACK_KLHL6 cd18446
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...
 149-239 5.66e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.


Pssm-ID: 350521 [Multi-domain]  Cd Length: 108  Bit Score: 62.49  E-value: 5.66e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 149 NCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTWIKYNVESRQK 228
Cdd:cd18446    5 NCVGILRLADAHSLESLKKQVQNYIIQNFSQVLNHEEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYKESERLP 84

                         90
                 ....*....|.
gi 157822141 229 HLPHLIAKVRL 239
Cdd:cd18446   85 LLPRVLENVRL 95
BACK_KLHL40_like cd18477
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...
 145-242 1.46e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.


Pssm-ID: 350552 [Multi-domain]  Cd Length: 99  Bit Score: 61.01  E-value: 1.46e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 145 ISLVNCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTWIKYNVE 224
Cdd:cd18477    1 LCLGNCLAIFRLGLLLDCPRLAVSARDFICAHFTLVAKDEDFLGLSADELIAIISSDGLNVEKEEAVFEAVMKWVREAKE 80

                         90
                 ....*....|....*...
gi 157822141 225 SRQKHLPHLIAKVRLHQL 242
Cdd:cd18477   81 NRQKALPTVFESIRFRLL 98
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 47-140 1.90e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 60.59  E-value: 1.90e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  47 FYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVN-MKERDDGSVTI--TNLSSKAVKAFLDYAYTGKTRITDDNVEMFFQ 123
Cdd:cd18307    1 FCDVVISVDNHSFAAHRNVLAAVSPFVKSLISSNdMKATDELSITIdcDYLSPETVEQLLDYFYTGKIVISEKNVEDLLK 80

                         90
                 ....*....|....*..
gi 157822141 124 LSSFLQVSFLSKACSDF 140
Cdd:cd18307   81 GAKYFNIPRLKDHCVDF 97
BACK_KLHL16_gigaxonin cd18455
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...
 146-242 2.52e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.


Pssm-ID: 350530 [Multi-domain]  Cd Length: 97  Bit Score: 60.41  E-value: 2.52e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 146 SLVNCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTWIKYNVES 225
Cdd:cd18455    1 SAENCIGIRDFAERFSCPHVHYVATEYLETHFRDVSSTEEFLELSPEKLKELLSRDKLNVGNEEYIFEAVLRWVRHDPEE 80

                         90
                 ....*....|....*..
gi 157822141 226 RQKHLPHLIAKVRLHQL 242
Cdd:cd18455   81 RKVHLKDLMSSCWRSGL 97
BTB_POZ_BACH1 cd18277
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-141 3.05e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349586 [Multi-domain]  Cd Length: 120  Bit Score: 60.85  E-value: 3.05e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  27 SEDHGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAmfevNMKERDDGSVTITNLSSKAVKAF---L 103
Cdd:cd18277    7 SSVHSTNVLLSLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHS----RIVGQADAELNITLPEEVTVKGFeplI 82

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 157822141 104 DYAYTGKTRITDDNVEMFFQLSSFLQVSFLSKACSDFL 141
Cdd:cd18277   83 QFAYTAKLILSKDNVDEVCKCVEFLSVHNIEESCFQFL 120
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
429-584 3.27e-11

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 64.41  E-value: 3.27e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 429 EWTSVSPLPRGIYYPEASACQNVIYVLGSEveiaDAFNPSLDcFFKYNATTDQWSELvAEF-GQFFHATLikAVPVNCTL 507
Cdd:COG3055    2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGL----SGGSASNS-FEVYDPATNTWSEL-APLpGPPRHHAA--AVAQDGKL 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 508 YI-------CDLSTY--KVYSFCPDTCVWKGEGSFECAGFNAGAIGIEDKIYILGGdYAPDEITDEVQVYHSSRSEWEEV 578
Cdd:COG3055   74 YVfggftgaNPSSTPlnDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGG-WDDGGNVAWVEVYDPATGTWTQL 152


                 ....*.
gi 157822141 579 SPMPRA 584
Cdd:COG3055  153 APLPTP 158
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 38-139 4.19e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 60.57  E-value: 4.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  38 LQSFREQN--VFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSV-TITNLSSKAVKAFLDYAYTGKTRIT 114
Cdd:cd18293    4 LQLHRQQNsgVFCDVLLQAEGESVPAHCCVLSACSPYLTERLSSEPPPAGQKVVlELQGLKAHTLLKLVDFLYTSELEVS 83

                         90       100
                 ....*....|....*....|....*
gi 157822141 115 DDNVEMFFQLSSFLQVSFLSKACSD 139
Cdd:cd18293   84 SEEAQDVLAAARRLQISELESLCLE 108
BACK_KBTBD8 cd18483
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 149-236 8.53e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.


Pssm-ID: 350558 [Multi-domain]  Cd Length: 97  Bit Score: 58.72  E-value: 8.53e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 149 NCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTWIKYNVESRQK 228
Cdd:cd18483    5 NSIGVFIFADHYGHQELKERSQDYIRKKFLSVTKEQEFLHLTKDQLISILNSDDLNVEKEEHVYESIIHWFEHEQSKREM 84


                 ....*...
gi 157822141 229 HLPHLIAK 236
Cdd:cd18483   85 HLPEIFAK 92
BACK_KLHL7 cd18447
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...
 145-239 8.96e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.


Pssm-ID: 350522 [Multi-domain]  Cd Length: 98  Bit Score: 58.91  E-value: 8.96e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 145 ISLVNCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTWIKYNVE 224
Cdd:cd18447    2 VDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEP 81

                         90
                 ....*....|....*
gi 157822141 225 SRQKHLPHLIAKVRL 239
Cdd:cd18447   82 NRQPYMVDILAKVRF 96
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-149 1.83e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 58.90  E-value: 1.83e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  30 HGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNmkerddgSVTITNLSSKAVKAFLDYAYTG 109
Cdd:cd18243   15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSIN-------NLVLQGCSSIGLRLVLEYLYTA 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 157822141 110 KTRITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSISLVN 149
Cdd:cd18243   88 NVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQN 127
BTB_POZ_ZBTB17_MIZ1 cd18206
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-140 2.26e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349515 [Multi-domain]  Cd Length: 112  Bit Score: 58.02  E-value: 2.26e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  30 HGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFevnMKERDDGSVTITNLSskAVKAFLDYAYTG 109
Cdd:cd18206    5 HSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLF---VDQKDVVHLDISNAA--GLGQVLEFMYTA 79

                         90       100       110
                 ....*....|....*....|....*....|.
gi 157822141 110 KTRITDDNVEMFFQLSSFLQVSFLSKACSDF 140
Cdd:cd18206   80 KLSLSPENVDDVLAVATFLQMQDIVTACHAL 110
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 50-128 2.32e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 56.91  E-value: 2.32e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157822141  50 FKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTRITDDNVEMFFQLSSFL 128
Cdd:cd01165    1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGGFRESGQAEINLRDISPEDFRALLEFLYGGKRDLDASNLLELLEAANFL 79
BTB_POZ_ZBTB10 cd18201
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-141 2.34e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349510 [Multi-domain]  Cd Length: 122  Bit Score: 58.43  E-value: 2.34e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  33 KILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDgSVTITNLSSKAVKAF---LDYAYTG 109
Cdd:cd18201    7 QLLQELNEQRKKGILCDVNIVVSGKVFRAHKNILVAGSRFFKTLYCFTNKESCD-QTTVTHLDVVAVQGFsviLDFMYSG 85

                         90       100       110
                 ....*....|....*....|....*....|..
gi 157822141 110 KTRITDDNVEMFFQLSSFLQVSFLSKACSDFL 141
Cdd:cd18201   86 NLVLTSQNAIEVMSVASYLQMTEVVQSCRNFI 117
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-138 3.13e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 57.74  E-value: 3.13e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  30 HGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEvnMKERDDGSVT-ITNLSSKAVKAFLDYAYT 108
Cdd:cd18204    1 HKTVFLKTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFK--KLEVDSSSVIeIDFLRSDIFEEVLNYMYT 78

                         90       100       110
                 ....*....|....*....|....*....|
gi 157822141 109 GKTRITDDNVEMFFQLSSFLQVSFLSKACS 138
Cdd:cd18204   79 AKISVKKEDVNLMMSSGQILGIRFLDKLCS 108
BTB_POZ_ZBTB8 cd18199
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-141 3.53e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349508 [Multi-domain]  Cd Length: 113  Bit Score: 57.43  E-value: 3.53e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  30 HGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSV-TITNLSSKAVKAFLDYAYT 108
Cdd:cd18199    1 HQSRLLGQLNEQRKQDFFCDCSIIVEGRIFKAHRNVLFASSGYFRMLLSHYIQDTGRPSTaSFDVFSSDAFSIILDFVYS 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 157822141 109 GKTRITDDNVEMFFQLSSFLQVSFLSKACSDFL 141
Cdd:cd18199   81 GKLSLTSQNVIEVMSAASYLQMTDVINVCKTFI 113
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-141 3.70e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 57.53  E-value: 3.70e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  30 HGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDG-SVTITNLSSKAVKAFLDYAYT 108
Cdd:cd18329    4 HQSRLLQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQNAKETGQPtVATFDVFSPDTFTIILDFVYS 83

                         90       100       110
                 ....*....|....*....|....*....|...
gi 157822141 109 GKTRITDDNVEMFFQLSSFLQVSFLSKACSDFL 141
Cdd:cd18329   84 GKLSLTSQNVIEVMSAASYLQMTDVISVCKTFI 116
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
301-459 3.92e-10

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 60.94  E-value: 3.92e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 301 NGENQYTFCYNIKTDSWKILSqshliDLPG-----SSLSSYGEKIFLTGGCKGkccrkvrlhiaesyhDATDQTWCYCPi 375
Cdd:COG3055  133 GGNVAWVEVYDPATGTWTQLA-----PLPTprdhlAAAVLPDGKILVIGGRNG---------------SGFSNTWTTLA- 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 376 knefffvsTMKTPRTMHTSVTALNRLFVIGGKTRgsqdikSLLDVESYDPLSKEWTSVSPLPRGIYYPEASACQNVIYVL 455
Cdd:COG3055  192 --------PLPTARAGHAAAVLGGKILVFGGESG------FSDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVI 257


                 ....
gi 157822141 456 GSEV 459
Cdd:COG3055  258 GGET 261
BACK_KLHL40_KBTBD5 cd18516
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...
 145-239 4.00e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.


Pssm-ID: 350591 [Multi-domain]  Cd Length: 99  Bit Score: 57.07  E-value: 4.00e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 145 ISLVNCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTWIKYNVE 224
Cdd:cd18516    1 LCLSNCLAIFRLGLLLDCPRLAVAARDFICDRFQLIARDEDFLQLSPDELIAIISSDSLNVEKEEDVFEAVMKWVGKDQE 80

                         90
                 ....*....|....*
gi 157822141 225 SRQKHLPHLIAKVRL 239
Cdd:cd18516   81 ERTKALPVLLESIRF 95
BTB_POZ_ZBTB7C_ZBTB36 cd18328
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-141 4.41e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349637 [Multi-domain]  Cd Length: 120  Bit Score: 57.58  E-value: 4.41e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  29 DHGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYT 108
Cdd:cd18328    7 NHSSEVLCSLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLFTAGTLADQPYVYEIDFVTPEALSAILEFAYT 86

                         90       100       110
                 ....*....|....*....|....*....|...
gi 157822141 109 GKTRITDDNVEMFFQLSSFLQVSFLSKACSDFL 141
Cdd:cd18328   87 STLTITTSNVKHILNAAQMLEIQCIINVCLEIM 119
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-141 7.41e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 57.16  E-value: 7.41e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  29 DHGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSV-------TITNLSSKAVKA 101
Cdd:cd18327    7 EHSSELLSCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFTGGGGGSGDLGAgggqdvcELDFVGPEALGA 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 157822141 102 FLDYAYTGKTRITDDNVEMFFQLSSFLQVSFLSKACSDFL 141
Cdd:cd18327   87 LLEFAYTATLTISSSNMREVLRAARLLEIPCVADACADIL 126
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 60-150 7.65e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 57.17  E-value: 7.65e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  60 PCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKA------VKAFLDYAYTGKTRITDDNVEMFFQLSSFLQVSFL 133
Cdd:cd18241   39 RAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKWSSEPgpdpdtVEAVIQYMYTGRIRVSTGNVHEVLELADRFLLIRL 118

                         90
                 ....*....|....*..
gi 157822141 134 SKACSDFLIKSISLVNC 150
Cdd:cd18241  119 KEFCGEFLKKKLNLSNC 135
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 34-145 1.04e-09

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 56.53  E-value: 1.04e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  34 ILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGS-----VTITNLSSKAVKAFLDYAYT 108
Cdd:cd18296    4 LDELPFPPEQELSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAESEENNgsipvVTLHDVSPEVFAIVLYYIYT 83

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 157822141 109 GKTRITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSI 145
Cdd:cd18296   84 DDTDLPPENAYDVLYVADMYLLPGLKRLCGTVLAQSL 120
BACK_KLHL41_KBTBD10 cd18517
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also ...
 145-230 1.13e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also called Kel-like protein 23, or Kelch repeat and BTB domain-containing protein 10, or Kelch-related protein 1 (Krp1), or sarcosine, is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils.


Pssm-ID: 350592 [Multi-domain]  Cd Length: 99  Bit Score: 55.55  E-value: 1.13e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 145 ISLVNCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTWIKYNVE 224
Cdd:cd18517    1 LSVGNCLAIFRLGLLLDCPRLAVSARDFVSDRFEQISKEEDFLQLAPHELIAIISSDSLNVEKEELVFEAVMKWVRTDKE 80


                 ....*.
gi 157822141 225 SRQKHL 230
Cdd:cd18517   81 NRVKSL 86
BACK_KBTBD12 cd18485
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 149-239 1.35e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also termed Kelch domain-containing protein 6 (KLHDC6), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350560 [Multi-domain]  Cd Length: 100  Bit Score: 55.50  E-value: 1.35e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 149 NCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTWIKYNVESRQK 228
Cdd:cd18485    5 NCLGIYYFAKQIGAEDLSDRARKYLYQHFTEVCLHEEVLEIEAHQLLTLIKSDDLNVSREESILDLVLRWVNHNRKSRVQ 84

                         90
                 ....*....|.
gi 157822141 229 HLPHLIAKVRL 239
Cdd:cd18485   85 HLVELLKQVRL 95
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 38-119 1.38e-09

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 56.10  E-value: 1.38e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  38 LQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTRITDDN 117
Cdd:cd18295   10 LRRLLEQGSYSDVTFNVHGESFPAHRCILSARSPYFAEMFETKWKDKREINLKHPLVNPDAFRALLQYLYTGRLEIHVDD 89


                 ..
gi 157822141 118 VE 119
Cdd:cd18295   90 VE 91
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-141 1.63e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 55.34  E-value: 1.63e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  36 SVLQSFREQNVfYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTRI-T 114
Cdd:cd18298    2 SLRKAFNDPRT-SDLKFRVDGKYIYVHKAILKIRCEYFRSMFQSHWNEDDKNVIEIDQYSYPVYYAFLRYLYTDQVDLpP 80

                         90       100
                 ....*....|....*....|....*..
gi 157822141 115 DDNVEMFFQLSSFLQVSFLSKaCSDFL 141
Cdd:cd18298   81 EDAIGLLDLANSYCEERLKKL-CEDII 106
BACK_KLHL21 cd18460
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...
 149-239 1.69e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.


Pssm-ID: 350535 [Multi-domain]  Cd Length: 101  Bit Score: 55.19  E-value: 1.69e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 149 NCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTWIKYNVESRQK 228
Cdd:cd18460    5 NCLEMQDFAEAFACRGLAEAAKRFILRHIVELAKGEQFERLPLKRLLEYLSDDGLCVDKEETAYQIALRWVKADPKHRQH 84

                         90
                 ....*....|.
gi 157822141 229 HLPHLIAKVRL 239
Cdd:cd18460   85 FWPELLQHVRL 95
BTB_POZ_ZBTB46 cd18230
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-141 1.82e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349539 [Multi-domain]  Cd Length: 125  Bit Score: 55.84  E-value: 1.82e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  30 HGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNL-SSKAVKAFLDYAYT 108
Cdd:cd18230    4 HYRHLLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVTHLDIvTAQGFKAIIDFMYS 83

                         90       100       110
                 ....*....|....*....|....*....|...
gi 157822141 109 GKTRITDDNVEMFFQLSSFLQVSFLSKACSDFL 141
Cdd:cd18230   84 AHLALTSKNVIEVMSAASYLQMTDIVQACHNFI 116
BACK_KLHL29_KBTBD9 cd18468
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...
 149-239 2.23e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.


Pssm-ID: 350543 [Multi-domain]  Cd Length: 102  Bit Score: 55.11  E-value: 2.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 149 NCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTWIKYNVESRQK 228
Cdd:cd18468    4 NCLGIWALAEALQCTELHNMAKAYALQNFPDVARQEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKWLKKDPKNRKQ 83

                         90
                 ....*....|.
gi 157822141 229 HLPHLIAKVRL 239
Cdd:cd18468   84 HIAELLAVVRL 94
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 62-149 2.76e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 54.97  E-value: 2.76e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  62 HRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTRITDDNVEMFFQL---SSFLQVSFLSKACS 138
Cdd:cd18297   27 HKIVLVTASDRFKSMLSSGSTEAQTPVIEIPDIRYDIFQLMMQYLYTGGVESLDVAQDDALELlraASFFQLDGLKRHCE 106

                         90
                 ....*....|.
gi 157822141 139 DFLIKSISLVN 149
Cdd:cd18297  107 ILLSQQIDLDN 117
BTB_POZ_KBTBD11 cd18275
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-154 2.76e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349584 [Multi-domain]  Cd Length: 104  Bit Score: 54.80  E-value: 2.76e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  59 IPCHRCVLAACSDFFRAMFEvnmkeRDdgSVTITNLSSKAVKAFLDYAYTGKTRITDDNVEMFFQLSSFLQVSFLSKACS 138
Cdd:cd18275   16 IRAHKSVLAAKSDYFRARLS-----RD--ILKVKGLSYATLRLLVDYVYSGRMAVSKDNVVEVVAGARFLQMPCAAQCAV 88

                         90
                 ....*....|....*.
gi 157822141 139 DFLIKSISLVNCLHLL 154
Cdd:cd18275   89 DAVRAQLCLGNCYEVL 104
BTB_POZ_BACH cd18955
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 49-141 3.08e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349736 [Multi-domain]  Cd Length: 94  Bit Score: 54.40  E-value: 3.08e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  49 DFKIIMKEEIIPCHRCVLAACSDFFRAmfevNMKERDDGSVTIT---NLSSKAVKAFLDYAYTGKTRITDDNVEMFFQLS 125
Cdd:cd18955    3 DVTIVVEDQRFRAHRAVLAACSDYFLS----RVVGQTDGDLVITlpeEVTVKGFEPLLQFAYTAKLLLSKENVLEVCRCA 78

                         90
                 ....*....|....*.
gi 157822141 126 SFLQVSFLSKACSDFL 141
Cdd:cd18955   79 EFLGVHNIEKACFDFL 94
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-141 3.76e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 54.56  E-value: 3.76e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  50 FKIIMKEEIIPCHRCVLAACSDFFRAMFEVN-MKERDDGSVTITNLSSKAVKAFLDYAYTGKTRITDDNVEMFFQLSSFL 128
Cdd:cd18294   19 FLVGPERQEIFAHKCILAARCEVFRAMFLTGpQKESTQSPLVLSDIEPEVFRAVLEFIYTNCVTLSNHTVIEVLAAAVEY 98

                         90
                 ....*....|...
gi 157822141 129 QVSFLSKACSDFL 141
Cdd:cd18294   99 GLDELRKLCERFI 111
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-111 3.80e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 54.84  E-value: 3.80e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157822141  43 EQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKT 111
Cdd:cd18279   14 ENSRFTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKA 82
BACK_KLHL35 cd18474
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...
 145-219 3.99e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.


Pssm-ID: 350549 [Multi-domain]  Cd Length: 79  Bit Score: 53.66  E-value: 3.99e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157822141 145 ISLVNCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTWI 219
Cdd:cd18474    1 IGANNCLALLAAADALHCAPLQEHCIRVLLRDFAQAARHPSFLKLELQLVLELLADDSLAVRSEEVVLEAALRWV 75
BACK_KLHL10 cd18450
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...
 145-222 4.42e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.


Pssm-ID: 350525 [Multi-domain]  Cd Length: 80  Bit Score: 53.38  E-value: 4.42e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157822141 145 ISLVNCLHLLSLSDSYGSAQLFSHTLYFVQHHF-HLLFKSRDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTWIKYN 222
Cdd:cd18450    1 LTPENCIGIRKFARYYFCPELERKAYRYILRNFeEVAKDSEEFLELSCEELEDIIEDDELNVKEEEVVFEAIVKWIDHD 79
BACK_KEL_like cd18508
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...
 149-222 4.47e-09

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.


Pssm-ID: 350583 [Multi-domain]  Cd Length: 77  Bit Score: 53.18  E-value: 4.47e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 157822141 149 NCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTWIKYN 222
Cdd:cd18508    4 NCLGIHEFADAHSCVELEEAAQNYIYQHFNEVIQGEEFLSLDHESLTELISSDRLNVPSEERVYEAAVAWLKHD 77
BACK_KLHL24 cd18463
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...
 149-221 5.53e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.


Pssm-ID: 350538 [Multi-domain]  Cd Length: 78  Bit Score: 53.17  E-value: 5.53e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 157822141 149 NCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTWIKY 221
Cdd:cd18463    6 NCLGIQKFADTHSLKQLFEKCKKFALENFVEVSQHEEFLELCKDELIEYISNDELVVPKEEEVFEAVMRWVYH 78
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-137 5.83e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 54.44  E-value: 5.83e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  29 DHGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDdgsvtITNLSSKAVKA-----FL 103
Cdd:cd18194    5 EHSRQLLQCLREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFHLFYRDRLDKRD-----LVRLNSDIVTApafglLL 79

                         90       100       110
                 ....*....|....*....|....*....|....
gi 157822141 104 DYAYTGKTRITDDNVEMFFQLSSFLQVSFLSKAC 137
Cdd:cd18194   80 DFMYEGRLALRDLPVEDVLAAASYLHMYDIVKVC 113
BACK_calicin cd18503
BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal ...
 149-222 8.27e-09

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa.


Pssm-ID: 350578 [Multi-domain]  Cd Length: 78  Bit Score: 52.74  E-value: 8.27e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157822141 149 NCLHLLSLSDSYGSAQLfSHTLY-FVQHHFHLLFKSRDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTWIKYN 222
Cdd:cd18503    5 NCLTALCLATTAGLKDL-SDEIYdYIRDNFFDVSGTREFLQCPYDIFSRLLKDENLHVNNEDQVLLALLNWTEHN 78
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-141 9.31e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 53.39  E-value: 9.31e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  33 KILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKerDDGSVTITNL---SSKAVKAFLDYAYTG 109
Cdd:cd18330    4 KLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLIHYIQ--DSGRHSTASLdivTSEAFSIILDFLYSG 81

                         90       100       110
                 ....*....|....*....|....*....|..
gi 157822141 110 KTRITDDNVEMFFQLSSFLQVSFLSKACSDFL 141
Cdd:cd18330   82 KLDLCSENVIEVMSAASYLQMTDVVNFCKGYI 113
BACK_KLHL19_KEAP1 cd18458
BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...
 149-234 1.07e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.


Pssm-ID: 350533 [Multi-domain]  Cd Length: 91  Bit Score: 52.68  E-value: 1.07e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 149 NCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTWIKYNVESRQK 228
Cdd:cd18458    6 NCIGIANFAEQHGCTELHKKAREYIYMHFSEVSQSEEFFNLSPCQLVALISRDELNVRCESEVYNAVIRWVKYDEENRRQ 85


                 ....*.
gi 157822141 229 HLPHLI 234
Cdd:cd18458   86 YLEALL 91
BACK_KLHL11 cd18451
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...
 145-230 1.09e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.


Pssm-ID: 350526 [Multi-domain]  Cd Length: 88  Bit Score: 52.66  E-value: 1.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 145 ISLVNCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTWIKYNVE 224
Cdd:cd18451    1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQDEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQRNAE 80


                 ....*.
gi 157822141 225 SRQKHL 230
Cdd:cd18451   81 ERERYF 86
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-141 1.18e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 53.41  E-value: 1.18e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  30 HGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFeVNMKERDDGSVTITNLSSKAVKAFLDYAYTG 109
Cdd:cd18278   14 HCTNILLCLNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFLQAL-VGQTENDLVVSLPEEVTARGFGPLLQFAYTA 92

                         90       100       110
                 ....*....|....*....|....*....|..
gi 157822141 110 KTRITDDNVEMFFQLSSFLQVSFLSKACSDFL 141
Cdd:cd18278   93 KLLLSRENIQEVIRCAEFLRMHNLEDSCFRFL 124
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-110 1.37e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 53.42  E-value: 1.37e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157822141  43 EQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGK 110
Cdd:cd18344   19 ENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHDLDPQVFKEMMGFIYTGK 86
BACK_KLHL38 cd18476
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ...
 149-239 1.47e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation.


Pssm-ID: 350551 [Multi-domain]  Cd Length: 99  Bit Score: 52.44  E-value: 1.47e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 149 NCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLESDELnVPEEEMVLKAVLTWIKYNVESRQK 228
Cdd:cd18476    5 NCLSMIRLSEILNCETLKKKAKDMALQCFPDVAASEDLKELCASELLDYLGDDEL-CGEEEQVFETLMVWIRHDPKARKG 83

                         90
                 ....*....|.
gi 157822141 229 HLPHLIAKVRL 239
Cdd:cd18476   84 YIHDLFKKVRL 94
BTB_POZ_ZBTB28_BCL6B cd18332
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-141 1.57e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349641 [Multi-domain]  Cd Length: 114  Bit Score: 52.94  E-value: 1.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  30 HGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFevnmKERDDGSVTITNLSS----KAVKAFLDY 105
Cdd:cd18332    2 HSSDVLLNLNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIF----SGRVGEGVSVLTLPSgleaRGFQLLLDF 77

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 157822141 106 AYTGKTRITDDNVEMFFQLSSFLQVSFLSKACSDFL 141
Cdd:cd18332   78 MYTSRLPLTPRTVPAVLAAATYLQMEHVVETCRRFI 113
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-116 1.89e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 52.93  E-value: 1.89e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157822141  43 EQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKT----RITDD 116
Cdd:cd18345   14 ERSAFSDVTLCVGGREFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITDVDHEVMREMLRFIYTGKApnldKMADD 91
BTB_POZ_ZBTB26_Bioref cd18214
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-145 2.04e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26); ZBTB26, also called zinc finger protein 481 (ZNF481) or zinc finger protein Bioref, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349523 [Multi-domain]  Cd Length: 122  Bit Score: 52.90  E-value: 2.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  28 EDHGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNmkerDDGSVTITNL-SSKAVKAFLDYA 106
Cdd:cd18214    6 ENYGDSMLQKMNKLREQNKFCDVTVHIDDLEVPGHKVVFAAGSPFLRDQFLLN----DSREVQISILqNSEVGRQLLLSC 81

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 157822141 107 YTGKTRITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSI 145
Cdd:cd18214   82 YTGVLEFPEMELVNYLTAASFLQMSHIVERCTQALWKFI 120
BTB_POZ_ZBTB3 cd18323
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-137 2.10e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349632 [Multi-domain]  Cd Length: 128  Bit Score: 52.91  E-value: 2.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  29 DHGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDdgSVTITN--LSSKAVKAFLDYA 106
Cdd:cd18323    5 DHSRHLLQSLREQRHQGFLCDCTVLVGSTQFLAHRAVLASCSPFFHMFYKEQLDKRD--LVCINNeiVTAPAFSLLLEFM 82

                         90       100       110
                 ....*....|....*....|....*....|.
gi 157822141 107 YTGKTRITDDNVEMFFQLSSFLQVSFLSKAC 137
Cdd:cd18323   83 YEGRLSFNDTPVEDVLAAASYLHMNDIVKVC 113
BTB_POZ_ZBTB18_2-like cd18325
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-137 2.10e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349634 [Multi-domain]  Cd Length: 128  Bit Score: 53.12  E-value: 2.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  29 DHGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDdgsvtITNLSSKAVKA-----FL 103
Cdd:cd18325    5 DHSRQLLQCLSQQRHQGFLCDCTVLVGEAQFRAHRAVLASCSMYFHLFYRDQLDKRD-----IVHLNSDIVTApafslLL 79

                         90       100       110
                 ....*....|....*....|....*....|....
gi 157822141 104 DYAYTGKTRITDDNVEMFFQLSSFLQVSFLSKAC 137
Cdd:cd18325   80 EFMYEGKLEFSSLPVEDVLAAASYLHMYDIVKVC 113
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-147 4.04e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 51.85  E-value: 4.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  43 EQNVF------YDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNmKERDDGSVTITNLSSKAVKAFLDYAYTGKTRITDD 116
Cdd:cd18231    6 EQRLFqpdlcdVDIVLVRQRSTFPAHKGVLAAYSQFFHSLFTQN-KQLQRVELSLEALTSQGLQQILNFIYTSKLLVNSC 84

                         90       100       110
                 ....*....|....*....|....*....|.
gi 157822141 117 NVEMFFQLSSFLQVSFLSKACSDfLIKSISL 147
Cdd:cd18231   85 NVQDVLNAAAVLQMNDIAASCQE-LIDSRSL 114
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 62-149 5.91e-08

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 51.32  E-value: 5.91e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  62 HRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTRITDDNVEMFFQLSSFLQVSFLSKACSDFL 141
Cdd:cd18352   28 HRIALLASSDAFRAMFDGGYREKEARDIEIPNIRWEVFELMMRFIYTGSVDITNDIAKDLLRAADQYLLEGLKRLCEYTI 107


                 ....*...
gi 157822141 142 IKSISLVN 149
Cdd:cd18352  108 AQDLTLEN 115
BTB_POZ_ZBTB18_RP58 cd18324
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-137 7.32e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349633 [Multi-domain]  Cd Length: 147  Bit Score: 51.96  E-value: 7.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  29 DHGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDdgsvtITNLSSKAVKA-----FL 103
Cdd:cd18324    5 DHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQLDKRD-----IVHLNSDIVTApafalLL 79

                         90       100       110
                 ....*....|....*....|....*....|....
gi 157822141 104 DYAYTGKTRITDDNVEMFFQLSSFLQVSFLSKAC 137
Cdd:cd18324   80 EFMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVC 113
BTB_POZ_ZBTB6 cd18197
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-141 8.06e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 6 (ZBTB6); ZBTB6, also called zinc finger protein 482 (ZNF482) or zinc finger protein with interaction domain, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349506 [Multi-domain]  Cd Length: 116  Bit Score: 51.02  E-value: 8.06e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  28 EDHGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERddgsVTITNLSSKAV-KAFLDYA 106
Cdd:cd18197    6 EQQGDAVLQKMNLLRQQNLFCDVSIYINDTEFHGHKVILAACSTFMRDQFLLNQSKQ----VRITILQSAEVgRKLLLSC 81

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 157822141 107 YTGKTRITDDNVEMFFQLSSFLQVSFLSKACSDFL 141
Cdd:cd18197   82 YTGALEVKKKELLKYLTAASYLQMVHIVEKCTEAL 116
BTB_POZ_ZBTB35_ZNF131 cd18221
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-136 1.06e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349530 [Multi-domain]  Cd Length: 113  Bit Score: 50.38  E-value: 1.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  30 HGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERddgSVTITNLSSKAVKAFLDYAYTG 109
Cdd:cd18221    1 HYKVMLDRLNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFFYKFFQDFTQEP---LVEIEGVSNMAFRHLIEFTYTA 77

                         90       100
                 ....*....|....*....|....*...
gi 157822141 110 KTRITD-DNVEMFFQLSSFLQVSFLSKA 136
Cdd:cd18221   78 KLMVQGeEEANDVWKAAEYLQMQEAIKA 105
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 40-145 1.20e-07

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 50.32  E-value: 1.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  40 SFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTRI--TDDN 117
Cdd:cd18300    2 LFLNKGLFSDVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFRESSAKEVELPGVSKETFLALLEYLYTDQAPIleDGDC 81

                         90       100
                 ....*....|....*....|....*...
gi 157822141 118 VEMfFQLSSFLQVSFLSKACSDFLIKSI 145
Cdd:cd18300   82 VGL-IVLANRLCLPRLVALCEQYIVKEL 108
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-137 1.52e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 50.14  E-value: 1.52e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  30 HGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFevnmKERDDGSVTI--TNLSSKAVKAFLDYAY 107
Cdd:cd18217    1 HCEQLLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQY----KDTEDNIVFLdqSQVSADGFQKLLEFIY 76

                         90       100       110
                 ....*....|....*....|....*....|
gi 157822141 108 TGKTRITDDNVEMFFQLSSFLQVSFLSKAC 137
Cdd:cd18217   77 TGNLNLDSWNVAEIHQAASYLGMEEVVAKC 106
BTB_POZ_BTBD14B_NAC1 cd18290
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 31-143 2.37e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349599 [Multi-domain]  Cd Length: 123  Bit Score: 49.65  E-value: 2.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  31 GQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNmkerDDGSVTI-TNLSSKAVKAFLDYAYTG 109
Cdd:cd18290   11 GNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSS----RSAVVELpAAVQPQSFQQILSFCYTG 86

                         90       100       110
                 ....*....|....*....|....*....|....
gi 157822141 110 KTRITDDNVEMFFQLSSFLQVSFLSKACSDFLIK 143
Cdd:cd18290   87 RLSMNVGDQFLLMYTAGFLQIQEIMEKGTEFFLK 120
BACK_KLHL33 cd18472
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...
 145-218 2.47e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.


Pssm-ID: 350547 [Multi-domain]  Cd Length: 75  Bit Score: 48.15  E-value: 2.47e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 157822141 145 ISLVNCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTW 218
Cdd:cd18472    1 LSPANCLELWAFADAATLPRLAAAARAFALKHFAEVAASAAFLSLPLARLLELLRSDELEVAEEEAVFEAAVRW 74
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 31-108 2.74e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 49.63  E-value: 2.74e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157822141  31 GQKILSVLQSFREQNVFYDfkiiMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYT 108
Cdd:cd18280    2 GQHFGALLESEEGADVTFN----VDGEKFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIEDVEPPVFKALLHFIYK 75
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 31-125 3.24e-07

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 49.18  E-value: 3.24e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  31 GQKILSVLQsfreQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGK 110
Cdd:cd18286    5 GKDLLQLFL----NGEDSDITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAAVSFVLLFIYGGV 80

                         90
                 ....*....|....*
gi 157822141 111 TRItDDNVEMFFQLS 125
Cdd:cd18286   81 LDL-PDDVNLGELLS 94
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 31-146 3.40e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 49.64  E-value: 3.40e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  31 GQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITnlsSKAVKAFLDYAYTGK 110
Cdd:cd18289   13 GNTVLGCLNEQRLMGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFELPATVP---PACFQQILSFCYTGK 89

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 157822141 111 TRITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSIS 146
Cdd:cd18289   90 LTMAASEQLVVMYTAGFLQIQHIVERGTDLMFKVSS 125
BTB_POZ_ZBTB49 cd18233
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-141 4.36e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349542 [Multi-domain]  Cd Length: 112  Bit Score: 48.74  E-value: 4.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  30 HGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDD-GSVTITNLSskAVKAFLDYAYT 108
Cdd:cd18233    1 HSCHLLQQLHEQRIQGLLCDCMLVVKGVCFKAHKNVLAAFSQYFRSLFQNSSSQKNDvFHLDIKNVG--GIGQILDFMYT 78

                         90       100       110
                 ....*....|....*....|....*....|...
gi 157822141 109 GKTRITDDNVEMFFQLSSFLQVSFLSKACSDFL 141
Cdd:cd18233   79 SHLDLNQDNVQVMLDIAQCLQVQNVLNMCYTFL 111
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 149-200 5.67e-07

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 46.50  E-value: 5.67e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 157822141 149 NCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLES 200
Cdd:cd14733    4 NCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55
BTB_POZ_ZBTB42 cd18956
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-141 5.80e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349737 [Multi-domain]  Cd Length: 129  Bit Score: 49.04  E-value: 5.80e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  29 DHGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFevnmKERDDGSVTITNLSSKAVKA-----FL 103
Cdd:cd18956    5 EHGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFHLFY----RDRPAGGRDTVRLNGDIVTApafgrLL 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 157822141 104 DYAYTGKTRITDDNVEMFFQLSSFLQVSFLSKACSDFL 141
Cdd:cd18956   81 DFMYEGRLDLRSLPVEDVLAAASYLHMYDIVKVCKGRL 118
Kelch smart00612
Kelch domain;
400-450 6.73e-07

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 46.01  E-value: 6.73e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 157822141   400 RLFVIGGkTRGSQDIKSlldVESYDPLSKEWTSVSPLPRGIYYPEASACQN 450
Cdd:smart00612   1 KIYVVGG-FDGGQRLKS---VEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 388-437 6.91e-07

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 46.07  E-value: 6.91e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 157822141  388 PRTMHTSVTALNRLFVIGGkTRGSQDIKSlldVESYDPLSKEWTSVSPLP 437
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGG-FDGNQSLNS---VEVYDPETNTWSKLPSMP 46
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-144 7.02e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 48.42  E-value: 7.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  30 HGQKILSVLQSFREQN-VFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFevNMKERDDGS---VTITNLSSKAVKAFLDY 105
Cdd:cd18207    9 HSADMLHNLNQQRKSGgRFCDVLLRVGEESFPAHRAVLAACSEYFESVF--SAQEGDGGTpreLEMHTISSKVFGDILDF 86

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 157822141 106 AYTGKTRITDDNVEMFFQLSSFLQVSFLSKACSDFLIKS 144
Cdd:cd18207   87 AYTSRIVVRLESFPELMTAAKFLLMRSVIDICQEVIKQS 125
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-140 7.37e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 48.05  E-value: 7.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  32 QKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMF-----------EVNMKERDDgsvtitnlSSKAVK 100
Cdd:cd18292    2 REFLQDIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLsndwwseskqsEIELVEDPE--------CAAVFE 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 157822141 101 AFLDYAYTGKTRITDDNVEMFFQLSSFLQVSFLSKACSDF 140
Cdd:cd18292   74 KFLRYLYTGQISVNLETALPLLMLADKYNVTDLKQLCVDF 113
BTB_POZ_CP190-like cd18311
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 34-135 9.41e-07

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349620 [Multi-domain]  Cd Length: 110  Bit Score: 47.58  E-value: 9.41e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  34 ILSVLQSFREQNVFYDFKI-IMKEEIIPCHRCVLAACSDFFRAMFEVnmKERDDGSVTITN-LSSKAVKAFLDYAYTGKT 111
Cdd:cd18311    1 FLQRLQNLFNKTEYCDLTLqFRDNEQLKVHRLVLSACTDYFNVLEQT--CEIVDDTLIMPNeLQADAVVPVINFMYTGQL 78

                         90       100
                 ....*....|....*....|....
gi 157822141 112 RITDDNVEMFFQLSSFLQVSFLSK 135
Cdd:cd18311   79 EFEEKSYGKLLRTAKELNMTVLLK 102
BACK_KLHL27_IPP cd18466
BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide ...
 149-247 9.86e-07

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also termed Kelch-like protein 27 (KLHL27), is an actin-binding protein that may play a role in organizing the actin cytoskeleton.


Pssm-ID: 350541 [Multi-domain]  Cd Length: 103  Bit Score: 47.47  E-value: 9.86e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 149 NCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTWIKYNVESRQK 228
Cdd:cd18466    5 NCIGIFQFSEQIACHDLLEFTENYIHVHFLEVQSGEEFLGLTKDQLVKILRSEELSIEDEYQVFTAAMEWILKDVGKRKK 84

                         90
                 ....*....|....*....
gi 157822141 229 HLPHLIAKVRLHQLSEASL 247
Cdd:cd18466   85 HVVEVLEPVRFPLLPPQRL 103
BTB_POZ_ZBTB27_BCL6 cd18331
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-141 1.16e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349640 [Multi-domain]  Cd Length: 118  Bit Score: 47.54  E-value: 1.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  30 HGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTG 109
Cdd:cd18331    7 HASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKCNLSVINLDPEINPEGFNILLDFMYTS 86

                         90       100       110
                 ....*....|....*....|....*....|..
gi 157822141 110 KTRITDDNVEMFFQLSSFLQVSFLSKACSDFL 141
Cdd:cd18331   87 RLNLREGNIMAVMATAMYLQMEHVVDTCRKFI 118
BTB_POZ_ZBTB5 cd18196
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-141 1.52e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349505 [Multi-domain]  Cd Length: 126  Bit Score: 47.73  E-value: 1.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  30 HGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVnmkERDDGSVTITNLSSKAVK-----AFLD 104
Cdd:cd18196    4 HFEQIFQQLNYQRLHGQLCDCVIVVGNRHFKAHRSVLAACSTHFRALFTV---AEGDQTMNMIQLDSEVVTaeafaALID 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 157822141 105 YAYTGKTRITDDNVEMFFQLSSFLQVSFLSKACSDFL 141
Cdd:cd18196   81 MMYTSTLMLGESNVMDVLLAASHLHLNSVVKACKHYL 117
BTB_POZ_ZBTB22_BING1 cd18210
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 31-141 1.72e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349519 [Multi-domain]  Cd Length: 112  Bit Score: 47.14  E-value: 1.72e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  31 GQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAmfEVNMKERDdgSVTITN-LSSKAVKAFLDYAYTG 109
Cdd:cd18210    5 TSSLLESLNQQRMEGKLCDISIHVQGRVFRAHRAVLAASSPYFHD--QVLLKNMS--SISLPGvMDPGAFESVLASAYTG 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 157822141 110 KTRITDDNVEMFFQLSSFLQVSFLSKACSDFL 141
Cdd:cd18210   81 KLTMLADEIVNYLTVGSVLQMWHIVDKCTELL 112
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-149 2.18e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 46.92  E-value: 2.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  43 EQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTRITDDNVEMFF 122
Cdd:cd18343   17 ENSRFTDCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKAPNLDKMADNLL 96

                         90       100
                 ....*....|....*....|....*..
gi 157822141 123 QLSSFLQVSFLSKACSDFLIKSISLVN 149
Cdd:cd18343   97 AAADKYALERLKVMCEEALCNNLSVEN 123
BACK_BTBD19 cd18494
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 19 (BTBD19); ...
 160-218 2.20e-06

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB-domain-containing Kelch-like protein. Its function remains unclear.


Pssm-ID: 350569  Cd Length: 73  Bit Score: 45.38  E-value: 2.20e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 157822141 160 YGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLESDELNVPEEEmVLKAVLTW 218
Cdd:cd18494   15 YGQDELKERCLAFIEEHTEEVFKTKGFHELSDEALSVILRSDKLRIDELD-ILKAVREW 72
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-140 2.49e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 46.71  E-value: 2.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  25 LASEDHGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFevnmKERDDGSVTITNLSSKAVKAF-- 102
Cdd:cd18212    1 IHSKTHKDTVLTNFEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMF----ADEGEVGQSIYMLEGMVAETFga 76

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 157822141 103 -LDYAYTGKTRITDDNVEMFFQLSSFLQVSFLSKACSDF 140
Cdd:cd18212   77 lLEFIYTGCLQVGEKSLEQILATAQFLKVNDLVKAYSDY 115
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 47-112 2.92e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 46.20  E-value: 2.92e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 157822141  47 FYDFKIIMKE-EIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTR 112
Cdd:cd18302    5 LYDVTIVSEDgKEFPCHKCVLVARLEYFHSMLSSSWIEASSCSALTMPIPSDILEIILDYLYTDEAS 71
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-150 5.16e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 45.78  E-value: 5.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  33 KILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKErddgsVTITNLSSKAVKAFLDYAYTGKTR 112
Cdd:cd18303    4 RLLKTVASLFDKELYSDITIKLADKSIPAHKFVLAARSEKWSNENLASTNE-----LDLSDISYEVVLALLRWLYTDELD 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 157822141 113 ITDDNVEM--FFQLSSFLQVSFLSKACSDFLIKSISLVNC 150
Cdd:cd18303   79 LTLDDEFLleLMKAAKRFQLTDLVERCERALMSSVNVDNC 118
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-135 5.46e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 45.61  E-value: 5.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  30 HGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMF-EVNMKERDDGSVTITNLSSKAVKAFLDYAYT 108
Cdd:cd18202    2 HGQTVLDQLNQQRLNNQFCDVTLLIEGEEYKAHKSVLAANSEYFRELFiEKGAVSSHEAVVDLSGFCKSSFLPLLEFAYT 81

                         90       100
                 ....*....|....*....|....*..
gi 157822141 109 GktritddnvEMFFQLSSFLQVSFLSK 135
Cdd:cd18202   82 S---------ELTFDFCSMAEVAMLAR 99
BTB_POZ_ETO1-like cd18190
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 49-126 7.21e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) and similar proteins; ETO1, also called protein ethylene overproducer 1, is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes. It may act as a substrate-specific adaptor that connects ACS enzymes, such as ACS5, to ubiquitin ligase complexes, leading to proteasomal degradation of ACS enzymes. The family also includes ETO1-like proteins 1 (EOL1) and 2 (EOL2). ETO1, EOL1, and EOL2 contain a BTB domain and tetratricopeptide (TPR) repeats. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349499 [Multi-domain]  Cd Length: 83  Bit Score: 44.43  E-value: 7.21e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  49 DFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKE--RDDGSVTITNLSSKAVKAFLDYAYTGKTRITD-DNVEMFFQLS 125
Cdd:cd18190    1 DLVFCVGGEKFCCVRKKIASLSRPFKAMLYGNFREstSDCIDFEENGISIEAMRAVIDFSVTGRLDLFSvENVHEVLELA 80


                 .
gi 157822141 126 S 126
Cdd:cd18190   81 S 81
BTB_POZ_ZBTB1 cd18192
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-139 7.25e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349501 [Multi-domain]  Cd Length: 114  Bit Score: 45.20  E-value: 7.25e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  30 HGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFevnmkERDDGSVTITNLSSKAVKA-----FLD 104
Cdd:cd18192    4 HSSYVLQQLNNQREWGFLCDCCIAIDDIYFQAHKAVLAACSSYFRMMF-----INHQHTTAQLNLSNMKISAecfdlILQ 78

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 157822141 105 YAYTGKTRITDDNVEMFFQLSSFLQVSFLSKACSD 139
Cdd:cd18192   79 FMYLGKIMTAPSDFEQLKVAMNYLQLYYIPECLED 113
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-140 9.13e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 44.75  E-value: 9.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  30 HGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKerddGSVTITNLSSKAVKAFLDYAYTG 109
Cdd:cd18232    1 HSVKVLQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLYGDGTS----GSVVLPESFAEVFGLLLDFFYTG 76

                         90       100       110
                 ....*....|....*....|....*....|.
gi 157822141 110 KTRITDDNVEMFFQLSSFLQVSFLSKACSDF 140
Cdd:cd18232   77 ELALTRENRDRVLLAAKELRVPEAVELCQRF 107
Kelch_6 pfam13964
Kelch motif;
388-439 9.23e-06

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 43.09  E-value: 9.23e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 157822141  388 PRTMHTSVTALNRLFVIGGKTRGSqdiKSLLDVESYDPLSKEWTSVSPLPRG 439
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNAS---PALNKLEVYNPLTKSWEELPPLPTP 49
BTB_POZ_ZBTB20_DPZF cd18208
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-138 9.26e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349517 [Multi-domain]  Cd Length: 117  Bit Score: 45.06  E-value: 9.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  34 ILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVtitnLSSKAVKAFLDYAYTGKTRI 113
Cdd:cd18208   12 VLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSV----VSVQSVQKLIDFMYSGVLRV 87

                         90       100
                 ....*....|....*....|....*
gi 157822141 114 TDDNVEMFFQLSSFLQVSFLSKACS 138
Cdd:cd18208   88 SQSEALQILTAASILQIKTVIDECT 112
BACK_KLHL31_KBTBD1 cd18470
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also ...
 145-243 1.06e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).


Pssm-ID: 350545  Cd Length: 98  Bit Score: 44.48  E-value: 1.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 145 ISLVNCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTWIKYNvE 224
Cdd:cd18470    1 INVENCMYVVNIAETYGLKNTKEAAQKFIRDNFIEFSETDQFLKLTFEQINEFLIDDDLQLPSEITAFQIAMKWLDFD-Q 79

                         90
                 ....*....|....*....
gi 157822141 225 SRQKHLPHLIAKVRLHQLS 243
Cdd:cd18470   80 KRVKYAADLLSNIRFGTIS 98
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 44-112 1.21e-05

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 45.38  E-value: 1.21e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157822141  44 QNVFYDFKIIMKE-EIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTIT--------NLSSKAVKAFLDYAYTGKTR 112
Cdd:cd18310   15 DLFYSDAEIIVEGgRPVPVHRCILAARSPFFRDIFASAKAEGANTKPKLElrelipggIVGYDAFMLVLSYLYSGRLR 92
BTB_POZ_ZBTB12 cd18203
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-145 1.25e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349512 [Multi-domain]  Cd Length: 122  Bit Score: 44.87  E-value: 1.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  30 HGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTitnLSSKAVKAFLDYAYTG 109
Cdd:cd18203    8 HEAATLRNMNQLRSEERFCDVTIVADSLKFRGHKVVLAACSPFLRDQFLLNPSSELQVSLM---HSSRVVADLLLSCYTG 84

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 157822141 110 KTRITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSI 145
Cdd:cd18203   85 ALEFSVRDIVNYLTAASYLQMEHVVEKCRGALSQFI 120
BACK_NS1BP_IVNS1ABP cd18502
BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); ...
 149-237 2.01e-05

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); NS1-BP, also called NS1-binding protein, or Aryl hydrocarbon receptor-associated protein 3, or IVNS1ABP, is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control.


Pssm-ID: 350577  Cd Length: 99  Bit Score: 43.76  E-value: 2.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 149 NCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLE---MNFGVLQKclESDELNVPEEEMVLKAVLTWIKYNVES 225
Cdd:cd18502    5 NCIGIRSFAGRMNDSELLQKVDSYIQENIEEVAESKEFLKlprLQIEVILE--SNQELESINERKLCQLVLEWVQRSIEE 82

                         90
                 ....*....|..
gi 157822141 226 RQKHLPHLIAKV 237
Cdd:cd18502   83 GGLDLDDLTEKV 94
BACK_KLHL42_KLHDC5 cd18478
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also ...
 145-199 2.08e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9), or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. KLHL42 is involved in microtubule dynamics throughout mitosis.


Pssm-ID: 350553  Cd Length: 103  Bit Score: 43.60  E-value: 2.08e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 157822141 145 ISLVNCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLE 199
Cdd:cd18478    1 IRLPNCLELYRLAQVYGLRDLAEACLKFMATHYHPMLRRPEFRPLPSSLKQQLRE 55
BACK_KBTBD6_7 cd18482
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing ...
 147-242 2.11e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing proteins, KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling.


Pssm-ID: 350557 [Multi-domain]  Cd Length: 99  Bit Score: 43.65  E-value: 2.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 147 LVNCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFL-EMNFGVLQKCLESDELNVPEEEMVLKAVLTWIKYNVES 225
Cdd:cd18482    3 LSNCAGILKFADAFDNRELKSKALAFIARNFQQLLAKEEELcELSLAQLKEVLMLDSLDVDSERKVCSVAVQWIEANLKE 82

                         90
                 ....*....|....*..
gi 157822141 226 RQKHLPHLIAKVRLHQL 242
Cdd:cd18482   83 RAASAAEVLKCVRWQHF 99
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 54-149 2.22e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 44.35  E-value: 2.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  54 MKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDgSVTITNLSSKAVKAFLDYAYTGKTRITDDNVEMFFQLSSFLQVSFL 133
Cdd:cd18281   33 DNEQRIPAHKFVLSIGSAVFDAMFNGGMATTSA-EIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPAL 111

                         90
                 ....*....|....*.
gi 157822141 134 SKACSDFLIKSISLVN 149
Cdd:cd18281  112 ESACVEFLKKNLSSDN 127
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 47-109 2.70e-05

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 43.92  E-value: 2.70e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157822141  47 FYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNL--SSKAVKAFLDYAYTG 109
Cdd:cd18309   20 FCDITLLLDGHPIPAHKAILAARCSYFEAMFRSFMPEDNTVNISIGEMvpSRQAFDSLLRYIYYG 84
BTB_POZ_BTBD3_6 cd18282
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 57-145 3.02e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349591 [Multi-domain]  Cd Length: 108  Bit Score: 43.54  E-value: 3.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  57 EIIPCHRCVLAACSDFFRAMFEVNMKERDDgSVTITNLSSKAVKAFLDYAYTGKTRITDDNV-EMFFQLSSFLqVSFLSK 135
Cdd:cd18282   21 QRIPAHKYVLATGSSVFYAMFYGGLAENKN-EIEIPDVEPAAFLNLLRYLYCDEIDLEPDTVlATLYAAKKYL-VPHLAR 98

                         90
                 ....*....|
gi 157822141 136 ACSDFLIKSI 145
Cdd:cd18282   99 ACVQFLETSL 108
BTB_POZ_BTBD6 cd18349
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-145 3.14e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349658 [Multi-domain]  Cd Length: 109  Bit Score: 43.43  E-value: 3.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  59 IPCHRCVLAACSDFFRAMFEVNMKErDDGSVTITNLSSKAVKAFLDYAYTGKTRITDDNVEMFFQLSSFLQVSFLSKACS 138
Cdd:cd18349   24 VPAHKYVLAVGSSVFYAMFYGDLAE-VKSEIHIPDVEPAAFLILLKYMYSDEIDLEADTVLATLYAAKKYIVPALAKACV 102


                 ....*..
gi 157822141 139 DFLIKSI 145
Cdd:cd18349  103 NFLETSL 109
BTB_POZ_RCBTB2_CHC1L cd18354
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-146 3.29e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2 is also called chromosome condensation 1-like (CHC1-L), RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2. It is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349663 [Multi-domain]  Cd Length: 117  Bit Score: 43.39  E-value: 3.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  28 EDHgqkiLSVLQSFREQ---NVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEvnmkERDDGSVTITNLSSKAVKAFLD 104
Cdd:cd18354    2 DDH----LTVAESLKREfdnPDTADLKFLVDGKYIYVHKVLLKIRCEHFRSLLN----ENEEEIIEMSQFSYPVYRAFLE 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 157822141 105 YAYTGKTRITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSIS 146
Cdd:cd18354   74 YLYTDSISLSPEDAIGLLDLATFYRENRLKKLCQQTIKQGIC 115
BTB_POZ_KLHL42 cd18319
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 51-129 4.28e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9) or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of katanin (KATNA1). KLHL42 is involved in microtubule dynamics throughout mitosis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349628 [Multi-domain]  Cd Length: 93  Bit Score: 42.55  E-value: 4.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  51 KIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTRIT--------DDN--VEM 120
Cdd:cd18319    5 QIRLEDRCYNVSKRKLIEQSDYFRALYRSGMRESGEEVVQLRGLSAPGLELVLDFINTSKVHESqgdstdtlEENelLED 84


                 ....*....
gi 157822141 121 FFQLSSFLQ 129
Cdd:cd18319   85 LVEAASFLQ 93
BTB_POZ_ZBTB30_HIC2 cd18334
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-137 6.96e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349643 [Multi-domain]  Cd Length: 120  Bit Score: 42.65  E-value: 6.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  29 DHGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAM-FEVNMKERDdgsvtiTNLSSKAV-KAFLDYA 106
Cdd:cd18334    3 NHAKQLLLQLNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFKSLvLHDNLINLD------TDMVNPTVfRQILDFI 76

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 157822141 107 YTGKTRITDD----NVEMFFQLSSFLQVSFLSKAC 137
Cdd:cd18334   77 YTGKLLTSDQpgeqNFNALLTAASYLQLHDLAALC 111
BTB_POZ_BTBD3 cd18348
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-154 9.61e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in the mammalian neocortex. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349657 [Multi-domain]  Cd Length: 131  Bit Score: 42.70  E-value: 9.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  59 IPCHRCVLAACSDFFRAMFEVNMKErDDGSVTITNLSSKAVKAFLDYAYTGKTRITDDNVEMFFQLSSFLQVSFLSKACS 138
Cdd:cd18348   37 LPGHKYVLAVGSSVFHAMFYGELAE-DKDEIRIPDVEPAAFLAMLKYIYCDEIDLAADTVLATLYAAKKYIVPHLARACV 115

                         90
                 ....*....|....*.
gi 157822141 139 DFLIKSISLVNCLHLL 154
Cdd:cd18348  116 NFLETSLSAKNACVLL 131
BACK_BTBD7 cd18489
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 7 (BTBD7); ...
 145-218 1.08e-04

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains and a BACK domain.


Pssm-ID: 350564  Cd Length: 98  Bit Score: 41.52  E-value: 1.08e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157822141 145 ISLVNCLHLLSLSDS-YGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLESDELNVPEEEmVLKAVLTW 218
Cdd:cd18489    1 LSLDTLVGILRWSSQpHGSQWVHRQALHFLREEFSQIAQSPVLFELTKEYLIEALQSDFLQASELD-ILKAVLKW 74
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 539-582 1.13e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 39.90  E-value: 1.13e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 157822141  539 NAGAIGIEDKIYILGGdYAPDEITDEVQVYHSSRSEWEEVSPMP 582
Cdd:pfam01344   4 GAGVVVVGGKIYVIGG-FDGNQSLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_ZBTB23_GZF1 cd18211
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 62-139 1.19e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349520 [Multi-domain]  Cd Length: 128  Bit Score: 42.15  E-value: 1.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  62 HRCVLAACSDFFRAMFeVNMKERD--DGSVTITNLSSKAVKAFLDYAYTGKTRITDDNVEMFFQLSSFLQVSFLSKACSD 139
Cdd:cd18211   44 HKAVLAASSKYFKEVF-LNEKISDgkNTNVMLNEIYTADFASFLEFVYTAKVEVEEDRVQRMLEIAEKLKCLDLSETCFQ 122
BTB_POZ_ZBTB37 cd18222
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-141 1.33e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349531 [Multi-domain]  Cd Length: 123  Bit Score: 41.95  E-value: 1.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  29 DHGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNmkerDDGSVTITNLSSKAV-KAFLDYAY 107
Cdd:cd18222    7 DFSNSVLSHLNQLRMQGRLCDIVVNVQGQSFRAHKVVLAASSPYFRDHMSLN----EMSTVSISVIKNPTVfEQLLSFCY 82

                         90       100       110
                 ....*....|....*....|....*....|....
gi 157822141 108 TGKTRITDDNVEMFFQLSSFLQVSFLSKACSDFL 141
Cdd:cd18222   83 TGRICLQLADIISYLTAASFLQMQHIIDKCTQIL 116
BACK_KLHL23 cd18462
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is ...
 147-239 1.53e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is involved in tumorigenesis and resistance to anticancer drug treatment. It also associates with cone-rod dystrophy.


Pssm-ID: 350537 [Multi-domain]  Cd Length: 102  Bit Score: 41.26  E-value: 1.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 147 LVNCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTWIKYNVESR 226
Cdd:cd18462    3 IDNCLGMHSFAEFHVCPELEKESRRIILSRFEEVWQQEEFLELSKEKLLYILSRENLNVWKEEVLIEAVVKWVAHDVEKR 82

                         90
                 ....*....|...
gi 157822141 227 QKHLPHLIAKVRL 239
Cdd:cd18462   83 IECAYDLLSSIKL 95
BACK_KLHL34 cd18473
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs ...
 145-238 1.61e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs to the KLHL family. Its function remains unclear. The methylation status of KLHL34 cg14232291 may be a predictive candidate of sensitivity to preoperative chemoradiation therapy.


Pssm-ID: 350548  Cd Length: 106  Bit Score: 41.26  E-value: 1.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 145 ISLVNCLHLLSLSDSYGSAQLFSHT-LYFVQHHFHLL---FKSRDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTWIK 220
Cdd:cd18473    1 LSPENCCFSANIAARFGLPDALKAAeKYIISNLWRLLasdADDAGLLELNLESLQAVLEADDIPRVKESRLLTLVLEWLN 80

                         90
                 ....*....|....*...
gi 157822141 221 YNvESRQKHLPHLIAKVR 238
Cdd:cd18473   81 QD-ESRLAYANALLSRIR 97
BTB1_POZ_KLHL33 cd18262
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 30-109 1.90e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349571 [Multi-domain]  Cd Length: 101  Bit Score: 41.04  E-value: 1.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  30 HGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAmfevNMKERDDGSVTIT-NLSSKAVKAFLDYAYT 108
Cdd:cd18262    1 HPSQFFGEAQRLREQRLLLDETVSVGGRSYGVHSVILAAVSSLFRE----RLLGSNGPLPPLSlEVTPVGWEAVLTFAYT 76


                 .
gi 157822141 109 G 109
Cdd:cd18262   77 G 77
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-149 2.10e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 41.63  E-value: 2.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  43 EQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTRITDDNVEMFF 122
Cdd:cd18342   18 ENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLL 97

                         90       100
                 ....*....|....*....|....*..
gi 157822141 123 QLSSFLQVSFLSKACSDFLIKSISLVN 149
Cdd:cd18342   98 AAADKYALERLKVMCEDALCSNLSVEN 124
BTB_POZ_ZBTB33_KAISO cd18219
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-134 2.69e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349528 [Multi-domain]  Cd Length: 106  Bit Score: 40.58  E-value: 2.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  30 HGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNmkerddGSVTITNLSSKAVKA-FLDYAYT 108
Cdd:cd18219    4 YSGSLLKSLNEQRGHGLFCDVTVIVEDRKFRAHKNILSASSTYFHQLFSVA------GQVVELNFIRADIFAeILNYIYS 77

                         90       100
                 ....*....|....*....|....*..
gi 157822141 109 GK-TRITDDNVEMFFQLSSFLQVSFLS 134
Cdd:cd18219   78 SKiVRVRSDLLEELIKSGQLLGVKFIA 104
PHA02713 PHA02713
hypothetical protein; Provisional
 30-486 2.78e-04

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 43.84  E-value: 2.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  30 HGQKILSVLQSFREQNVFYDFKIIMKE-EIIPCHRCVLAACSDFFRAMFEVNMKERDdgSVTITNLS---SKAVKAFLDY 105
Cdd:PHA02713   8 HNRRVVSNISNLLDDDILCDVIITIGDgEEIKAHKTILAAGSKYFRTLFTTPMIIRD--LVTRVNLQmfdKDAVKNIVQY 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 106 AYTgkTRITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSISLVNCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRD 185
Cdd:PHA02713  86 LYN--RHISSMNVIDVLKCADYLLIDDLVTDCESYIKDYTNHDTCIYMYHRLYEMSHIPIVKYIKRMLMSNIPTLITTDA 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 186 FLEMNFGVLQKCLES-DELNVPEEEMVLKAVLTWIKYNVESRQKHLPhLIAKVRLHQLSEASlqDCLLneeYLLKSTNCF 264
Cdd:PHA02713 164 FKKTVFEILFDIISTnDNVYLYREGYKVTILLKWLEYNYITEEQLLC-ILSCIDIQNLDKKS--RLLL---YSNKTINMY 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 265 ETIVDAIKRVQGSSGLFPdarpstTEKYIFIHKTEENGENQYTFCYNIKTDSWKILS--QSHLIDLPGS----------- 331
Cdd:PHA02713 238 PSCIQFLLDNKQNRNIIP------RQLCLVCHDTKYNVCNPCILVYNINTMEYSVIStiPNHIINYASAivdneiiiagg 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 332 ----------------------------------SLSSYGEKIFLTGGCKGKCCRKVrlhiAESYhDATDQTWCYCP--- 374
Cdd:PHA02713 312 ynfnnpslnkvykinienkihvelppmiknrcrfSLAVIDDTIYAIGGQNGTNVERT----IECY-TMGDDKWKMLPdmp 386

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 375 ---------IKNEFFFVSTMKTPRTMHTSVTALNRLFViggktrgSQDIKSLLDVESYDPLSKEWTSVSPLPRGIYYPEA 445
Cdd:PHA02713 387 ialssygmcVLDQYIYIIGGRTEHIDYTSVHHMNSIDM-------EEDTHSSNKVIRYDTVNNIWETLPNFWTGTIRPGV 459

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|.
gi 157822141 446 SACQNVIYVLgseVEIADAFNPSlDCFFKYNATTDQWSELV 486
Cdd:PHA02713 460 VSHKDDIYVV---CDIKDEKNVK-TCIFRYNTNTYNGWELI 496
Kelch_4 pfam13418
Galactose oxidase, central domain;
388-437 3.88e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 38.36  E-value: 3.88e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 157822141  388 PRTMHTSV-TALNRLFVIGGKTRgsqDIKSLLDVESYDPLSKEWTSVSPLP 437
Cdd:pfam13418   1 PRAYHTSTsIPDDTIYLFGGEGE---DGTLLSDLWVFDLSTNEWTRLGSLP 48
BTB_POZ_BTBD1 cd18346
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-149 4.01e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349655 [Multi-domain]  Cd Length: 133  Bit Score: 40.81  E-value: 4.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  59 IPCHRCVLAACSDFFRAMFEVNMKErDDGSVTITNLSSKAVKAFLDYAYTGKTRITDDNVEMFFQLSSFLQVSFLSKACS 138
Cdd:cd18346   44 IPAHRFVLAAGSAVFDAMFNGGMAT-TSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCV 122

                         90
                 ....*....|.
gi 157822141 139 DFLIKSISLVN 149
Cdd:cd18346  123 EFLTKHLRADN 133
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 38-141 5.41e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 39.50  E-value: 5.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  38 LQSFREQNVFYDFKIIMKEEI-IPCHRCVLAACSDFFRAMFEVNMKerddgsVTITNL-SSKAVKAFLDYAYTGKTRITD 115
Cdd:cd18299    3 LRNLLHSPSCADVVFILQGGVrIFAHRIVLAAASSVFADLFLMMTV------VTLDSDiTPEAFRRVLEFLYTGVLDENE 76

                         90       100
                 ....*....|....*....|....*.
gi 157822141 116 DNVEMFFQLSSFLQVSFLSKACSDFL 141
Cdd:cd18299   77 DDLKELKDAAELLELFDLVMMCTNVL 102
BTB1_POZ_BTBD7 cd18283
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 49-125 9.55e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349592 [Multi-domain]  Cd Length: 92  Bit Score: 38.47  E-value: 9.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  49 DFKIIMKEEIIPCHRCVLAACSDFFRAMFevnMKERDDGSVTITNLSSKAV-----KAFLDYAYTGKTRITD---DNVEM 120
Cdd:cd18283    4 DVDLVFQGTCFPVHRAILSARCPFFRDLL---SSSPGYGAEIPVDLPTAGIdvpmfSALLRYLYTGEFGSEDsrsQNLDV 80


                 ....*
gi 157822141 121 FFQLS 125
Cdd:cd18283   81 LIQLS 85
BTB_POZ_ZBTB9 cd18200
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-141 9.90e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349509 [Multi-domain]  Cd Length: 111  Bit Score: 39.07  E-value: 9.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  30 HGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNmkerDDGSVTITN-LSSKAVKAFLDYAYT 108
Cdd:cd18200    1 YSSALLETLNKHRLEGKFCDLSVHVQGRVFRAHKAVLAASSPYFHDKLLLN----DTNCLVLPSvIEAAAFENLLQLIYS 76

                         90       100       110
                 ....*....|....*....|....*....|...
gi 157822141 109 GKTRITDDNVEMFFQLSSFLQVSFLSKACSDFL 141
Cdd:cd18200   77 GRLTLCMDALPSHLLVASGLQMWQVVDRCSELL 109
BTB_POZ_ZBTB4 cd18195
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-74 1.02e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349504 [Multi-domain]  Cd Length: 124  Bit Score: 39.49  E-value: 1.02e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 157822141  30 HGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFR 74
Cdd:cd18195    1 HAGALLLQLNEQRLRGLFCDVTLIAGDTKFRAHRSVLAASSPYFR 45
BACK_KLHL9_13 cd18449
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...
 145-238 1.08e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.


Pssm-ID: 350524 [Multi-domain]  Cd Length: 95  Bit Score: 38.56  E-value: 1.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 145 ISLVNCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTWIKYnVE 224
Cdd:cd18449    1 VSLENCVEIGRIANTYHLTEVDKYVNDFILKNFPALLSTGDFVKLPFERLAFVLSSNSLKGCTELELFKAACRWLRH-ED 79

                         90
                 ....*....|....
gi 157822141 225 SRQKHLPHLIAKVR 238
Cdd:cd18449   80 DRMQFAAKLMENIR 93
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-77 1.13e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 39.00  E-value: 1.13e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 157822141  30 HGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMF 77
Cdd:cd18223    1 HSDTVLSCLNEQRIQGILCDVTIVVEDTKFKAHKNVLAASSLYFKNAF 48
Kelch_6 pfam13964
Kelch motif;
542-582 1.25e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 36.93  E-value: 1.25e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 157822141  542 AIGIEDKIYILGGDYAPDEITDEVQVYHSSRSEWEEVSPMP 582
Cdd:pfam13964   7 VVSVGGYIYVFGGYTNASPALNKLEVYNPLTKSWEELPPLP 47
BACK_KBTBD4 cd18481
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 149-227 1.56e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also termed BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates.


Pssm-ID: 350556  Cd Length: 88  Bit Score: 37.95  E-value: 1.56e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157822141 149 NCLHLLSLSDSYGSAQLFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLESdelNVPEEEMVLKAVLTWIKYNVESRQ 227
Cdd:cd18481    5 NCLQVMWLADQHSDQELYTAAKHCAKTHLSQLHQTEEFLNLPLRLLTDIIKD---GVPCSQNPTAAIEAWINHNKEERE 80
BTB_POZ_ZBTB16_PLZF cd18205
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-141 1.87e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349514 [Multi-domain]  Cd Length: 107  Bit Score: 38.09  E-value: 1.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  30 HGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEvnmkeRDDGSVTITNLSSKAVKAFLDYAYTG 109
Cdd:cd18205    1 HPTGLLHKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILFH-----RNSQHYTLDFLSPKTFQQILEYAYTA 75

                         90       100       110
                 ....*....|....*....|....*....|..
gi 157822141 110 KTRITDDNVEMFFQLSSFLQVSFLSKACSDFL 141
Cdd:cd18205   76 TLQAKVEDLDDLLYAAEILEIEYLEEQCLKIL 107
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-137 2.15e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 38.27  E-value: 2.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  25 LASEDHGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFevnmkERDDGSVTITN----LSSKAVK 100
Cdd:cd18224    4 LHSSDHPNNLLKELNKCRLSETMCDVTIVVGNRSFAAHKAVLACAAGYFQKLF-----LSTELDVARTYvvdfITPANFE 78

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 157822141 101 AFLDYAYTGKTRITDDNVEMFFQLSSFLQVSFLSKAC 137
Cdd:cd18224   79 KVLSFIYTSELFTDLINVGVIYEVAEKLGMEDLLKAC 115
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-138 2.23e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 38.32  E-value: 2.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  30 HGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFevnmKERDDGSVTITNLSSKAVKAF---LDYA 106
Cdd:cd18209    1 HAISLLSALNEERLKGQLCDVLLIVGDQKFRAHKNVLAASSEYFQSLF----TEKENESQSVFQLDFCEPDAFenvLNYI 76

                         90       100       110
                 ....*....|....*....|....*....|..
gi 157822141 107 YTGKTRITDDNVEMFFQLSSFLQVSFLSKACS 138
Cdd:cd18209   77 YSSSLFVEKSSLAAVQELGYSLGISFLTNIVS 108
BTB_POZ_ZBTB34 cd18220
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-141 2.29e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349529 [Multi-domain]  Cd Length: 120  Bit Score: 38.47  E-value: 2.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  29 DHGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFramfevnmkeRDDGSV-TITNLSSKAVKA------ 101
Cdd:cd18220    7 EYSNTVLSQLNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYF----------RDHSALsTMSGLSISVIKNpnvfeq 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 157822141 102 FLDYAYTGKTRITDDNVEMFFQLSSFLQVSFLSKACSDFL 141
Cdd:cd18220   77 LLSFCYTGRMSLQLKDVVSFLTAASFLQMQCVIDKCTQIL 116
BTB2_POZ_RHOBTB3 cd18360
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 38-108 2.33e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349669 [Multi-domain]  Cd Length: 110  Bit Score: 37.91  E-value: 2.33e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157822141  38 LQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYT 108
Cdd:cd18360    1 LGLFFNSPLLADVVFKIQGTTVPAHRAVLVARCEVMAAMFNGNYAEAKSFLVPIYGVSKDTFLSFLEYLYT 71
Kelch smart00612
Kelch domain;
548-588 2.52e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 36.00  E-value: 2.52e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 157822141   548 KIYILGGdYAPDEITDEVQVYHSSRSEWEEVSPMPRALTEF 588
Cdd:smart00612   1 KIYVVGG-FDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGH 40
BTB2_POZ_RHOBTB1 cd18358
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 44-165 2.84e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1); RhoBTB1 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB1 functions as a tumor suppressor that regulates the integrity of the Golgi complex through the methyltransferase METTL7B. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349667 [Multi-domain]  Cd Length: 126  Bit Score: 38.02  E-value: 2.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  44 QNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGktritddnvemffQ 123
Cdd:cd18358   17 KGTFSDVTFKLDDGTINAHKPLLICSCEWMAAMFGGSFIESANSEVVLPNISKVSMQAVLDYLYTK-------------Q 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 157822141 124 LSSFLQVSFLskacsdfliKSISLVN--CL-HLLSLSDSYGSAQL 165
Cdd:cd18358   84 LSPTADLDPL---------ELIALANrfCLpHLVALTEQHAVQEL 119
BTB_POZ_ZBTB40 cd18225
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-141 3.95e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349534 [Multi-domain]  Cd Length: 116  Bit Score: 37.50  E-value: 3.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  29 DHGQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEvnmkERDDGSVTITNLSSKAVKAFLDYAYT 108
Cdd:cd18225    5 NYSRQLLQQLHTLRKEQQFCDCTIFIGTFHFRAHKLVLAASSLLFKSLLD----STDTISIDASVVSPEEFALLLEMVYT 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 157822141 109 GKTRITDDNVEMFFQLSSFLQVSFLSKACSDFL 141
Cdd:cd18225   81 GKLPPGKHNFTKIISVADSLQMFDVAVSCKNLL 113
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 31-109 4.25e-03

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 36.88  E-value: 4.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  31 GQKILSVLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMF----EVNMKERDDGSVTITNLSSKAVKAFLDYA 106
Cdd:cd18301    2 QEDFKKLLDEADEGDNIHDVVFQVGGKTFPAHKFILASRSDYFRKLFlsslLTSEDAVGCDVVHIEKVPPEIFEQLLQFI 81


                 ...
gi 157822141 107 YTG 109
Cdd:cd18301   82 YTD 84
BTB_POZ_ZBTB45 cd18229
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-144 5.06e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349538 [Multi-domain]  Cd Length: 112  Bit Score: 37.15  E-value: 5.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141  36 SVLQSFREQNV---FYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVtitnLSSKAVKAFLDYAYTGKTR 112
Cdd:cd18229    4 SLLETLNAQRLgghFCDVTVRIHDASLRAHRCVLAAGSPFFHDKLLLGHSEIEVPPV----VPAQTVRQLVEFMYSGSLV 79

                         90       100       110
                 ....*....|....*....|....*....|..
gi 157822141 113 ITDDNVEMFFQLSSFLQVSFLSKACSDFLIKS 144
Cdd:cd18229   80 VAQSEALQILTAASILQIKTVIDECTQIISQS 111
BACK_KLHL15 cd18454
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a ...
 145-247 8.27e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for Cullin3 E3 ubiquitin-protein ligase complex that target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation.


Pssm-ID: 350529  Cd Length: 108  Bit Score: 36.41  E-value: 8.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822141 145 ISLVNCLHLLSLSDSYG------SAQLFShtlyFVQHHFHLLFKSRDFLE-MNFGVLQKCLESDELN-VPEEEMvLKAVL 216
Cdd:cd18454    1 ICLDNCAEIMRLLDDFSvniegvREKLDS----FLLENFVPLMSRPDFLSyLSFEKLMSYLDNDHLSrFPEIEL-YEAVQ 75

                         90       100       110
                 ....*....|....*....|....*....|.
gi 157822141 217 TWIKYNvESRQKHLPHLIAKVRLHQLSEASL 247
Cdd:cd18454   76 AWLRHD-RRRWRHTDTIIQNIRFCLMTPTNV 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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