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Conserved domains on  [gi|157820021|ref|NP_001102067|]
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cystatin 9-like precursor [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CY super family cl09238
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 43-136 2.32e-08

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


The actual alignment was detected with superfamily member smart00043:

Pssm-ID: 447698  Cd Length: 107  Bit Score: 48.58  E-value: 2.32e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820021    43 PTVEFAVNTFNQKSQDEYAYRMEHIMSSWREEVDhPIVFSMRLRLRRTICKKFEESLDICPFQESHDRNntftCLFTVGT 122
Cdd:smart00043  18 EAADFAVAEYNKKSNDKYELRVIKVVSAKSQVVA-GTNYYLKVEVGETNCKKLSVDLENCPFLDQGEKF----CTAKVWE 92

                           90
                   ....*....|....
gi 157820021   123 LPWITEFQLFKNVC 136
Cdd:smart00043  93 KPWENKIKLVEFKC 106
 
Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 43-136 2.32e-08

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 48.58  E-value: 2.32e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820021    43 PTVEFAVNTFNQKSQDEYAYRMEHIMSSWREEVDhPIVFSMRLRLRRTICKKFEESLDICPFQESHDRNntftCLFTVGT 122
Cdd:smart00043  18 EAADFAVAEYNKKSNDKYELRVIKVVSAKSQVVA-GTNYYLKVEVGETNCKKLSVDLENCPFLDQGEKF----CTAKVWE 92

                           90
                   ....*....|....
gi 157820021   123 LPWITEFQLFKNVC 136
Cdd:smart00043  93 KPWENKIKLVEFKC 106
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 36-125 5.57e-06

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 41.94  E-value: 5.57e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820021   36 DKSVNFIPTVEFAVNTFNQKSQDEYaYRMEHIMSSwREEVDHPIVFSMRLRLRRTICKKFEESLDICPFqesHDRNNTFT 115
Cdd:pfam00031   8 DNSPELQEALDFALAEYNAKTDNYY-FELVEVKRA-KSQVVAGTNYFIKVEVGETDCSKSKKLLEDCPL---LDEKWLGL 82

                          90
                  ....*....|
gi 157820021  116 CLFTVGTLPW 125
Cdd:pfam00031  83 CSAQVYKVPW 92
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 43-136 6.86e-05

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 39.38  E-value: 6.86e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820021  43 PTVEFAVNTFNQKSQDEYaYRMEHIMSSwREEVDHPIVFSMRLRLRRTICKKFEESLDiCPFQESHDRNNTFTCLFTVGT 122
Cdd:cd00042   15 ELADFAVAEYNKKSNDKY-LEFFKVLSA-KSQVVAGTNYYITVEAGDTNCKKSSVPLD-CPDCKLLEEGKKKFCTAKVWE 91

                         90
                 ....*....|....
gi 157820021 123 LPWITEFQLFKNVC 136
Cdd:cd00042   92 KPWENFKELLSFKC 105
 
Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 43-136 2.32e-08

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 48.58  E-value: 2.32e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820021    43 PTVEFAVNTFNQKSQDEYAYRMEHIMSSWREEVDhPIVFSMRLRLRRTICKKFEESLDICPFQESHDRNntftCLFTVGT 122
Cdd:smart00043  18 EAADFAVAEYNKKSNDKYELRVIKVVSAKSQVVA-GTNYYLKVEVGETNCKKLSVDLENCPFLDQGEKF----CTAKVWE 92

                           90
                   ....*....|....
gi 157820021   123 LPWITEFQLFKNVC 136
Cdd:smart00043  93 KPWENKIKLVEFKC 106
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 36-125 5.57e-06

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 41.94  E-value: 5.57e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820021   36 DKSVNFIPTVEFAVNTFNQKSQDEYaYRMEHIMSSwREEVDHPIVFSMRLRLRRTICKKFEESLDICPFqesHDRNNTFT 115
Cdd:pfam00031   8 DNSPELQEALDFALAEYNAKTDNYY-FELVEVKRA-KSQVVAGTNYFIKVEVGETDCSKSKKLLEDCPL---LDEKWLGL 82

                          90
                  ....*....|
gi 157820021  116 CLFTVGTLPW 125
Cdd:pfam00031  83 CSAQVYKVPW 92
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 43-136 6.86e-05

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 39.38  E-value: 6.86e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820021  43 PTVEFAVNTFNQKSQDEYaYRMEHIMSSwREEVDHPIVFSMRLRLRRTICKKFEESLDiCPFQESHDRNNTFTCLFTVGT 122
Cdd:cd00042   15 ELADFAVAEYNKKSNDKY-LEFFKVLSA-KSQVVAGTNYYITVEAGDTNCKKSSVPLD-CPDCKLLEEGKKKFCTAKVWE 91

                         90
                 ....*....|....
gi 157820021 123 LPWITEFQLFKNVC 136
Cdd:cd00042   92 KPWENFKELLSFKC 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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