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Conserved domains on  [gi|157824222|ref|NP_001102983|]
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grpE protein homolog 2, mitochondrial [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 73-216 3.48e-49

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


:

Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 157.28  E-value: 3.48e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222  73 QDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTAECFSDGAEpqdhkltLEKVFQGLSLLEAK 152
Cdd:cd00446    1 KELKDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEAAPKEEE-------LKNLLEGVEMTLKQ 73

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 157824222 153 LKSVFTKHGLEKMAPIGDKYDPHEHELICHMPAGvGVQPGTVALVRQDGYKLHGRTIRLAQVEV 216
Cdd:cd00446   74 LLKVLEKHGVEEIEPEGEKFDPNLHEAVMQVESP-DKEPGTVVEVLQKGYKLHDRVLRPAMVVV 136
 
Name Accession Description Interval E-value
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 73-216 3.48e-49

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 157.28  E-value: 3.48e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222  73 QDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTAECFSDGAEpqdhkltLEKVFQGLSLLEAK 152
Cdd:cd00446    1 KELKDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEAAPKEEE-------LKNLLEGVEMTLKQ 73

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 157824222 153 LKSVFTKHGLEKMAPIGDKYDPHEHELICHMPAGvGVQPGTVALVRQDGYKLHGRTIRLAQVEV 216
Cdd:cd00446   74 LLKVLEKHGVEEIEPEGEKFDPNLHEAVMQVESP-DKEPGTVVEVLQKGYKLHDRVLRPAMVVV 136
GrpE pfam01025
GrpE;
58-217 1.69e-42

GrpE;


Pssm-ID: 425996 [Multi-domain]  Cd Length: 165  Bit Score: 141.21  E-value: 1.69e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222   58 EQALRLKAVKLEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTAECFSDGAEpqdhkl 137
Cdd:pfam01025  13 IESLEEEIEELEKKIEELKEKLLRALAEFENLRKRTEKEKEEAKKFAIEKFAKDLLPVIDNLERALNSAPENED------ 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222  138 tLEKVFQGLSLLEAKLKSVFTKHGLEKMAPIGDKYDPHEHELICHMPAGvGVQPGTVALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:pfam01025  87 -VKSLLEGVEMTLKQLLKILEKHGVEKIEPEGEPFDPNLHEAVSQVPSP-EKPEGTVVEVLQKGYKLHDRVLRPAMVVVS 164
GrpE COG0576
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein ...
 67-217 6.04e-42

Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440341 [Multi-domain]  Cd Length: 147  Bit Score: 139.13  E-value: 6.04e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222  67 KLEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTAECFSDGAEpqdhkltLEKVFQGL 146
Cdd:COG0576    3 ELEAELAELKDRLLRLQAEFENYRKRTEREREEARKYALEKLAEDLLPVLDNLERALAAAEEDED-------VKSLLEGV 75

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157824222 147 SLLEAKLKSVFTKHGLEKMAPIGDKYDPHEHELICHMPAGvGVQPGTVALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:COG0576   76 EMTLKQLLDVLEKHGVEEIEPVGEPFDPNLHEAVSQVPSP-DVEPGTVVEVLQKGYRLGDRVLRPAMVVVA 145
PRK14155 PRK14155
heat shock protein GrpE; Provisional
 48-217 7.37e-31

heat shock protein GrpE; Provisional


Pssm-ID: 237627 [Multi-domain]  Cd Length: 208  Bit Score: 112.75  E-value: 7.37e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222  48 PPDGLGPSLAEQALRLKAVKLEkeVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTAecfs 127
Cdd:PRK14155   7 PAEDGPFEADDAAQEIEALKAE--VAALKDQALRYAAEAENTKRRAEREMNDARAYAIQKFARDLLGAADNLGRAT---- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222 128 dGAEPQDHKLTLEKVF-QGLSLLEAKLKSVFTKHGLEKMAP-IGDKYDPHEHELICHMPaGVGVQPGTVALVRQDGYKLH 205
Cdd:PRK14155  81 -AASPKDSADPAVKNFiIGVEMTEKELLGAFERNGLKKIDPaKGDKFDPHLHQAMMEQP-STEVAAGGVLQVMQAGYELM 158

                        170
                 ....*....|..
gi 157824222 206 GRTIRLAQVEVA 217
Cdd:PRK14155 159 GRLVRPAMVAVA 170
 
Name Accession Description Interval E-value
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 73-216 3.48e-49

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 157.28  E-value: 3.48e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222  73 QDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTAECFSDGAEpqdhkltLEKVFQGLSLLEAK 152
Cdd:cd00446    1 KELKDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEAAPKEEE-------LKNLLEGVEMTLKQ 73

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 157824222 153 LKSVFTKHGLEKMAPIGDKYDPHEHELICHMPAGvGVQPGTVALVRQDGYKLHGRTIRLAQVEV 216
Cdd:cd00446   74 LLKVLEKHGVEEIEPEGEKFDPNLHEAVMQVESP-DKEPGTVVEVLQKGYKLHDRVLRPAMVVV 136
GrpE pfam01025
GrpE;
58-217 1.69e-42

GrpE;


Pssm-ID: 425996 [Multi-domain]  Cd Length: 165  Bit Score: 141.21  E-value: 1.69e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222   58 EQALRLKAVKLEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTAECFSDGAEpqdhkl 137
Cdd:pfam01025  13 IESLEEEIEELEKKIEELKEKLLRALAEFENLRKRTEKEKEEAKKFAIEKFAKDLLPVIDNLERALNSAPENED------ 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222  138 tLEKVFQGLSLLEAKLKSVFTKHGLEKMAPIGDKYDPHEHELICHMPAGvGVQPGTVALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:pfam01025  87 -VKSLLEGVEMTLKQLLKILEKHGVEKIEPEGEPFDPNLHEAVSQVPSP-EKPEGTVVEVLQKGYKLHDRVLRPAMVVVS 164
GrpE COG0576
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein ...
 67-217 6.04e-42

Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440341 [Multi-domain]  Cd Length: 147  Bit Score: 139.13  E-value: 6.04e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222  67 KLEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTAECFSDGAEpqdhkltLEKVFQGL 146
Cdd:COG0576    3 ELEAELAELKDRLLRLQAEFENYRKRTEREREEARKYALEKLAEDLLPVLDNLERALAAAEEDED-------VKSLLEGV 75

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157824222 147 SLLEAKLKSVFTKHGLEKMAPIGDKYDPHEHELICHMPAGvGVQPGTVALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:COG0576   76 EMTLKQLLDVLEKHGVEEIEPVGEPFDPNLHEAVSQVPSP-DVEPGTVVEVLQKGYRLGDRVLRPAMVVVA 145
PRK14155 PRK14155
heat shock protein GrpE; Provisional
 48-217 7.37e-31

heat shock protein GrpE; Provisional


Pssm-ID: 237627 [Multi-domain]  Cd Length: 208  Bit Score: 112.75  E-value: 7.37e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222  48 PPDGLGPSLAEQALRLKAVKLEkeVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTAecfs 127
Cdd:PRK14155   7 PAEDGPFEADDAAQEIEALKAE--VAALKDQALRYAAEAENTKRRAEREMNDARAYAIQKFARDLLGAADNLGRAT---- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222 128 dGAEPQDHKLTLEKVF-QGLSLLEAKLKSVFTKHGLEKMAP-IGDKYDPHEHELICHMPaGVGVQPGTVALVRQDGYKLH 205
Cdd:PRK14155  81 -AASPKDSADPAVKNFiIGVEMTEKELLGAFERNGLKKIDPaKGDKFDPHLHQAMMEQP-STEVAAGGVLQVMQAGYELM 158

                        170
                 ....*....|..
gi 157824222 206 GRTIRLAQVEVA 217
Cdd:PRK14155 159 GRLVRPAMVAVA 170
PRK14141 PRK14141
heat shock protein GrpE; Provisional
 68-217 2.57e-27

heat shock protein GrpE; Provisional


Pssm-ID: 172630  Cd Length: 209  Bit Score: 103.60  E-value: 2.57e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222  68 LEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTAECFSDGA-EPQDHKLTleKVFQGL 146
Cdd:PRK14141  43 LKAENAELKDRMLRLAAEMENLRKRTQRDVADARAYGIAGFARDMLSVSDNLRRALDAIPAEArAAADAGLK--ALIEGV 120

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157824222 147 SLLEAKLKSVFTKHGLEKMAPIGDKYDPHEHELICHMPaGVGVQPGTVALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK14141 121 EMTERAMLNALERHGVKKLDPEGQKFDPNFHQAMFEVP-NPDVPNNTVVQVVQAGYTIGERVLRPAMVGVA 190
PRK14139 PRK14139
heat shock protein GrpE; Provisional
 34-217 5.07e-27

heat shock protein GrpE; Provisional


Pssm-ID: 237621 [Multi-domain]  Cd Length: 185  Bit Score: 101.97  E-value: 5.07e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222  34 ATQRTAGEDCSSEDPPDGLGPSLAEqaLRLKAvkleKEVQDLTLRyqrAVADCENIRRRTQRCVEDAKIFGIQSFCKDLV 113
Cdd:PRK14139  19 AAQAAAAAAAAAEDAAPALEAELAE--AEAKA----AELQDSFLR---AKAETENVRRRAQEDVAKAHKFAIESFAESLL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222 114 EVADILEktaecfsdgAEPQDHKLTLEKVFQGLSLLEAKLKSVFTKHGLEKMAPIGDKYDPHEHELICHMPAgvGVQPGT 193
Cdd:PRK14139  90 PVKDSLE---------AALADESGDLEKLREGVELTLKQLTSAFEKGRVVEINPVGEKFDPHQHQAISMVPA--EQEPNT 158

                        170       180
                 ....*....|....*....|....
gi 157824222 194 VALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK14139 159 VVAVLQKGYTIADRVLRPALVTVA 182
PRK14150 PRK14150
heat shock protein GrpE; Provisional
 36-217 2.92e-23

heat shock protein GrpE; Provisional


Pssm-ID: 184539 [Multi-domain]  Cd Length: 193  Bit Score: 92.29  E-value: 2.92e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222  36 QRTAGEDCSSEDPPDGLGPSLAEQALRLKAvkLEKEVQDLTLRyqrAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEV 115
Cdd:PRK14150  23 QQEEADEAELEDELDEADARIAELEAQLAE--AQAEERDSVLR---ARAEVENIRRRAEQDVEKAHKFALEKFANELLPV 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222 116 ADILEKTAEcfsdGAEPQDHklTLEKVFQGLSLLEAKLKSVFTKHGLEKMAPIGDKYDPHEHELICHMPAGvGVQPGTVA 195
Cdd:PRK14150  98 IDNLERALQ----AADKENE--ALKALIEGVELTLKSLLDTVAKFGVEVVGPVGEPFNPEVHQAISMQESE-DHEPNTVM 170

                        170       180
                 ....*....|....*....|..
gi 157824222 196 LVRQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK14150 171 MVMQKGYTLNGRLLRPAMVMVS 192
PRK14140 PRK14140
heat shock protein GrpE; Provisional
 68-217 1.28e-20

heat shock protein GrpE; Provisional


Pssm-ID: 237622 [Multi-domain]  Cd Length: 191  Bit Score: 85.44  E-value: 1.28e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222  68 LEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTAECFSDGAEPQDHKLTLEKVFQglS 147
Cdd:PRK14140  49 LEAKLDELEERYLRLQADFENYKRRIQKENEAAEKYRAQSLASDLLPALDNFERALQIEADDEQTKSLLKGVEMVHR--Q 126

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222 148 LLEAklksvFTKHGLEKMAPIGDKYDPHEHELICHMPAGvGVQPGTVALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK14140 127 LLEA-----LKKEGVEVIEAVGEQFDPNLHQAVMQDEDE-DFESNEVVEELQKGYKLKDRVIRPSMVKVN 190
PRK14148 PRK14148
heat shock protein GrpE; Provisional
 55-214 1.44e-20

heat shock protein GrpE; Provisional


Pssm-ID: 172637 [Multi-domain]  Cd Length: 195  Bit Score: 85.57  E-value: 1.44e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222  55 SLAEQALRLKAV--KLEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTAEcfsdgaep 132
Cdd:PRK14148  37 SVEEQLERAKDTikELEDSCDQFKDEALRAKAEMENIRKRAERDVSNARKFGIEKFAKELLPVIDSIEQALK-------- 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222 133 qdHKLTLEKVF---QGLSLLEAKLKSVFTKHGLEKMAPIGDKYDPHEHELICHMPaGVGVQPGTVALVRQDGYKLHGRTI 209
Cdd:PRK14148 109 --HEVKLEEAIamkEGIELTAKMLVDILKKNGVEELDPKGEKFDPNLHEAMAMIP-NPEFEDNTIFDVFQKGYMLNGRIV 185


                 ....*
gi 157824222 210 RLAQV 214
Cdd:PRK14148 186 RAAKV 190
PRK14144 PRK14144
heat shock protein GrpE; Provisional
 29-217 3.28e-20

heat shock protein GrpE; Provisional


Pssm-ID: 184535 [Multi-domain]  Cd Length: 199  Bit Score: 84.78  E-value: 3.28e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222  29 HPFSTATQRTAGEDCSSEDPPDGLGPSLAEqaLRLKAVKLEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSF 108
Cdd:PRK14144  20 HKVENEILEEETDEESQHQEPALGHPSYTA--LEEQLTLAEQKAHENWEKSVRALAELENVRRRMEREVANAHKYGVEKL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222 109 CKDLVEVADILEKTAECFSDGAEPQDHkltlekvfQGLSLLEAKLKSVFTKHGLEKMAPIGDKYDPHEHELICHMPAGvG 188
Cdd:PRK14144  98 ISALLPVVDSLEQALQLADKNSDPSMH--------EGLELTMKLFLDALQKFDVEQIDPLGQTFDPQQHEAMSMQPAP-G 168

                        170       180
                 ....*....|....*....|....*....
gi 157824222 189 VQPGTVALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK14144 169 APPNSVITVFQKGYKLSDRVIRPARVIVS 197
PRK14151 PRK14151
heat shock protein GrpE; Provisional
 57-217 1.50e-19

heat shock protein GrpE; Provisional


Pssm-ID: 172640 [Multi-domain]  Cd Length: 176  Bit Score: 82.13  E-value: 1.50e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222  57 AEQALRLKAVKLEKEVQDLTLRYQ-------RAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTAECfsdg 129
Cdd:PRK14151  14 AAQAEAAAGDDLTARVQELEEQLAaakdqslRAAADLQNVRRRAEQDVEKAHKFALEKFAGDLLPVVDSLERGLEL---- 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222 130 AEPQDHklTLEKVFQGLSLLEAKLKSVFTKHGLEKMAPIGDKYDPHEHELIChMPAGVGVQPGTVALVRQDGYKLHGRTI 209
Cdd:PRK14151  90 SSADDE--AIKPMREGVELTLKMFQDTLKRYQLEAVDPHGEPFNPEHHQAMA-MQESADVEPNSVLKVFQKGYLLNGRLL 166


                 ....*...
gi 157824222 210 RLAQVEVA 217
Cdd:PRK14151 167 RPAMVVVS 174
PRK14154 PRK14154
heat shock protein GrpE; Provisional
 36-217 5.90e-19

heat shock protein GrpE; Provisional


Pssm-ID: 237626 [Multi-domain]  Cd Length: 208  Bit Score: 81.39  E-value: 5.90e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222  36 QRTAGEDCSSEDPP--DGLG-PSlaEQALRLKAVKLEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDL 112
Cdd:PRK14154  31 QEEGGGDGSQEMEPhrEGLEfPS--REKLEGQLTRMERKVDEYKTQYLRAQAEMDNLRKRIEREKADIIKFGSKQLITDL 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222 113 VEVADILEKTAEcfsdgaEPQDHKLTLEKVFQGLSLLEAKLKSVFTKHGLEKMAP-IGDKYDPHEHELIcHMPAGVGVQP 191
Cdd:PRK14154 109 LPVADSLIHGLE------SPASEDPQVKSMRDGMSLTLDLLHNTLAKHGVQVINPnPGDPFDPALHEAM-SVQAVPDAKP 181

                        170       180
                 ....*....|....*....|....*.
gi 157824222 192 GTVALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK14154 182 DTIIQVLQKGYQLNGRVLRAARVIVA 207
PRK10325 PRK10325
heat shock protein GrpE; Provisional
 42-217 6.15e-19

heat shock protein GrpE; Provisional


Pssm-ID: 182379 [Multi-domain]  Cd Length: 197  Bit Score: 81.26  E-value: 6.15e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222  42 DCSSE--DPPDglgpslaEQALRLKA--VKLEKEVQDLTLRYQravADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVAD 117
Cdd:PRK10325  31 EASAEqvDPRD-------EKIANLEAqlAEAQTRERDGILRVK---AEMENLRRRTELDIEKAHKFALEKFINELLPVID 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222 118 ILEKTAECfSDGAEPQdhkltLEKVFQGLSLLEAKLKSVFTKHGLEKMAPIGDKYDPHEHELIChMPAGVGVQPGTVALV 197
Cdd:PRK10325 101 SLDRALEV-ADKANPD-----MSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIA-MVESDDVAPGNVLGI 173

                        170       180
                 ....*....|....*....|
gi 157824222 198 RQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK10325 174 MQKGYTLNGRTIRAAMVTVA 193
PRK14159 PRK14159
heat shock protein GrpE; Provisional
 67-217 2.66e-18

heat shock protein GrpE; Provisional


Pssm-ID: 172647 [Multi-domain]  Cd Length: 176  Bit Score: 78.96  E-value: 2.66e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222  67 KLEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTAEcfsdgAEPQDhKLTL---EKVF 143
Cdd:PRK14159  34 KLQKDYDELKDKYMRANAEFENIKKRMEKEKLSAMAYANESFAKDLLDVLDALEAAVN-----VECHD-EISLkikEGVQ 107

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 157824222 144 QGLSLLEAKLKsvftKHGLEKMAPIGDkYDPHEHELICHMPaGVGVQPGTVALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK14159 108 NTLDLFLKKLE----KHGVALIKEEKE-FDPNLHEAMFHVD-SENHQSGEVVQVLQKGYKIADRVIRPTKVSVA 175
PRK14147 PRK14147
heat shock protein GrpE; Provisional
 45-217 8.32e-17

heat shock protein GrpE; Provisional


Pssm-ID: 237625 [Multi-domain]  Cd Length: 172  Bit Score: 74.99  E-value: 8.32e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222  45 SEDPPDGLGPSLAEQALRLKAVKLEKEvqdlTLRYQ---------RAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEV 115
Cdd:PRK14147   2 NQDHPEFDSEDLAQNPPETDPLKAEVE----SLRSEialvkadalRERADLENQRKRIARDVEQARKFANEKLLGELLPV 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222 116 ADILEktAECFSDGAEPQDHKltlekvfQGLSLLEAKLKSVFTKHGLEKMAPIGDKYDPHEHELICHMPAgVGVQPGTVA 195
Cdd:PRK14147  78 FDSLD--AGLTAAGTEPSPLR-------DGLELTYKQLLKVAADNGLTLLDPVGQPFNPEHHQAISQGEA-EGVAPGHVV 147

                        170       180
                 ....*....|....*....|..
gi 157824222 196 LVRQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK14147 148 QVFQKGYLLNERLLRPALVVVA 169
PRK14153 PRK14153
heat shock protein GrpE; Provisional
 32-217 1.01e-16

heat shock protein GrpE; Provisional


Pssm-ID: 184540 [Multi-domain]  Cd Length: 194  Bit Score: 75.26  E-value: 1.01e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222  32 STATQRTAGEDCSSEDPPDGLGPSLAEQALRLKAVKLEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKD 111
Cdd:PRK14153   9 DKAENSEARNSGSSAEEAEELKEEPEDSTADSETEKCREEIESLKEQLFRLAAEFDNFRKRTAREMEENRKFVLEQVLLD 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222 112 LVEVADILEKTAEcfsdGAEPQDhklTLEKVFQGLSLLEAKLKSVFTKHGLEKMAPIGDKYDPHEHELICHMPAGvGVQP 191
Cdd:PRK14153  89 LLEVTDNFERALE----SARTAE---DMNSIVEGIEMVSKQFFSILEKYGLERIECEGEEFDPHRHEAMMHVETS-EVPD 160

                        170       180
                 ....*....|....*....|....*.
gi 157824222 192 GTVALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK14153 161 NTIVDVCKPGYALNSKVIRPAMVSVA 186
PRK14161 PRK14161
heat shock protein GrpE; Provisional
 66-217 1.17e-16

heat shock protein GrpE; Provisional


Pssm-ID: 237630 [Multi-domain]  Cd Length: 178  Bit Score: 74.63  E-value: 1.17e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222  66 VKLEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTAEcfsdgAEPQDHKLTLEKVFQG 145
Cdd:PRK14161  29 TALKAEIEELKDKLIRTTAEIDNTRKRLEKARDEAKDYAIATFAKELLNVSDNLSRALA-----HKPANSDVEVTNIIAG 103

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 157824222 146 LSLLEAKLKSVFTKHGLEKMAP-IGDKYDPHEHELICHMpAGVGVQPGTVALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK14161 104 VQMTKDELDKVFHKHHIEEIKPeIGSMFDYNLHNAISQI-EHPDHAPNSIITLMQSGYKIRDRLLRPATVQVV 175
PRK14149 PRK14149
heat shock protein GrpE; Provisional
 43-217 7.27e-16

heat shock protein GrpE; Provisional


Pssm-ID: 184538 [Multi-domain]  Cd Length: 191  Bit Score: 72.98  E-value: 7.27e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222  43 CSSEDPPDGLGPSLAEQALRLKAvKLEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKT 122
Cdd:PRK14149  24 CACKEQQGEEKQEASEKEGEIKE-DFELKYKEMHEKYLRVHADFENVKKRLERDKSMALEYAYEKIALDLLPVIDALLGA 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222 123 AEcfSDGAEPQDHKLTlekvfQGLSLLEAKLKSVFTKHGLEKMAPIGDkYDPHEHELICHMPAGvGVQPGTVALVRQDGY 202
Cdd:PRK14149 103 LK--SAAEVDKESALT-----KGLELTMEKLHEVLARHGIEGIECLEE-FDPNFHNAIMQVKSE-EKENGKIVQVLQQGY 173

                        170
                 ....*....|....*
gi 157824222 203 KLHGRTIRLAQVEVA 217
Cdd:PRK14149 174 KYKGRVLRPAMVSIA 188
PRK14143 PRK14143
heat shock protein GrpE; Provisional
 39-217 5.79e-14

heat shock protein GrpE; Provisional


Pssm-ID: 237624 [Multi-domain]  Cd Length: 238  Bit Score: 68.60  E-value: 5.79e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222  39 AGEDCSSEDPPDGLGPSLAEQALRLKAVK-----LEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLV 113
Cdd:PRK14143  45 AAEAESSPDSGSAASETAADNAARLAQLEqelesLKQELEELNSQYMRIAADFDNFRKRTSREQEDLRLQLKCNTLSEIL 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222 114 EVADILEKTAECFsdgaEPQ-DHKLTLEKVFQGLSlleAKLKSVFTKHGLEKMAPIGDKYDPHEHELICHMPAGVGVQpG 192
Cdd:PRK14143 125 PVVDNFERARQQL----KPEgEEAQALHRSYQGLY---KQLVDVLKRLGVSPMRVVGQEFDPNLHEAVLREPSDEHPE-D 196

                        170       180
                 ....*....|....*....|....*
gi 157824222 193 TVALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK14143 197 VVLEELQRGYHLGGRVLRHAMVKVS 221
PRK14162 PRK14162
heat shock protein GrpE; Provisional
 54-217 3.59e-12

heat shock protein GrpE; Provisional


Pssm-ID: 237631 [Multi-domain]  Cd Length: 194  Bit Score: 62.93  E-value: 3.59e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222  54 PSLAEQALRLKAVKLEKEVQDLTLR-------YQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTAECF 126
Cdd:PRK14162  30 PKEEDQEKQNPVEDLEKEIADLKAKnkdledkYLRSQAEIQNMQNRYAKERAQLIKYESQSLAKDVLPAMDNLERALAVK 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222 127 SDGAEPQDHKLTLEKVFQGLslleaklKSVFTKHGLEKMAPIGDKYDPHEHELICHMPAGVGVQPGTVALVRQDGYKLHG 206
Cdd:PRK14162 110 ADDEAAKQLKKGVQMTLDHL-------VKALKDHGVTEIKADGEKFDPTLHQAVQTVAAENDDQKDHVVQVLQKGYQYKD 182

                        170
                 ....*....|.
gi 157824222 207 RTIRLAQVEVA 217
Cdd:PRK14162 183 RTLRPAMVVVA 193
PRK14145 PRK14145
heat shock protein GrpE; Provisional
 41-217 2.85e-10

heat shock protein GrpE; Provisional


Pssm-ID: 184536 [Multi-domain]  Cd Length: 196  Bit Score: 57.62  E-value: 2.85e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222  41 EDCSSEDPPDGL--------GPSLAE-QALRLKAVKLEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKD 111
Cdd:PRK14145  21 SNEQMEGPPEDEqaqqnqpqQQTVDEiEELKQKLQQKEVEAQEYLDIAQRLKAEFENYRKRTEKEKSEMVEYGKEQVILE 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222 112 LVEVADILEKTAECFSDGAEPQdhkltlekvfQGLSLLEAKLKSVFTKHGLEKMAPIGDKYDPHEHELICHMPAGvGVQP 191
Cdd:PRK14145 101 LLPVMDNFERALASSGDYNSLK----------EGIELIYRQFKKILDKFGVKEIEAEGQIFDPYKHHAVMQEEVE-GKQP 169

                        170       180
                 ....*....|....*....|....*.
gi 157824222 192 GTVALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK14145 170 NEIIEVFQKGYYLKDKVIRPSLVKVA 195
PRK14163 PRK14163
heat shock protein GrpE; Provisional
 32-217 3.19e-10

heat shock protein GrpE; Provisional


Pssm-ID: 184546 [Multi-domain]  Cd Length: 214  Bit Score: 57.83  E-value: 3.19e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222  32 STATQRTAGEDCSSEDPPDGLGPSLAEQALRLKAVKLEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKD 111
Cdd:PRK14163  16 SGATPDDAEPKAASEEGAAPAGDAAATAGLTAQLDQVRTALGERTADLQRLQAEYQNYRRRVERDRVTVKEIAVANLLSE 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222 112 LVEVADilektaecfsDGAEPQDHKltleKVFQGLSLLEAKLKSVFTKHGLEKMAPIGDKYDPHEHELICHMPAGVGVQP 191
Cdd:PRK14163  96 LLPVLD----------DVGRAREHG----ELVGGFKSVAESLETTVAKLGLQQFGKEGEPFDPTIHEALMHSYAPDVTET 161

                        170       180
                 ....*....|....*....|....*.
gi 157824222 192 GTVALVrQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK14163 162 TCVAIL-QPGYRIGERTIRPARVAVA 186
PRK14157 PRK14157
heat shock protein GrpE; Provisional
 32-217 3.80e-10

heat shock protein GrpE; Provisional


Pssm-ID: 184543 [Multi-domain]  Cd Length: 227  Bit Score: 57.66  E-value: 3.80e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222  32 STATQRTAGEDCSSEDPPDGLGPSLAEQALRLKAVklekevqdltlryQRAVADCENIRRRTQRCVEDAKIFGIqsfckd 111
Cdd:PRK14157  66 KAAAEKTGEAQSDSDDTLTPLGQAKKEAAEYLEAL-------------QRERAEFINYRNRTQKEQDRFRQHGI------ 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222 112 lvevADILEKTAECFSDGAEPQDHKlTLEKVFQGLSlleAKLKSVFTKHGLEKMAPIGDKYDPHEHELICHMPaGVGVQP 191
Cdd:PRK14157 127 ----IDVLTALLPALDDIDRIREHS-EMDDSFKAVA---AKIDKAFEKFGVEKFGEKGEDFDPTKHDAILHKP-DPDAEK 197

                        170       180
                 ....*....|....*....|....*.
gi 157824222 192 GTVALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK14157 198 ETVDTVVEAGYRIGDRVIRAARVVVA 223
PRK14160 PRK14160
heat shock protein GrpE; Provisional
 41-217 8.74e-08

heat shock protein GrpE; Provisional


Pssm-ID: 237629 [Multi-domain]  Cd Length: 211  Bit Score: 50.91  E-value: 8.74e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222  41 EDCSSEDPPDGLGPS---LAEQALRLKA--VKLEKEVQDLTLRYQRAVADCENIRRRTQRcvEDAKIFgiQSFCKD---- 111
Cdd:PRK14160  41 KEEIIEDSEESNEVKieeLKDENNKLKEenKKLENELEALKDRLLRTVAEYDNYRKRTAK--EKEGIY--SDACEDvlke 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222 112 LVEVADILEKTAEcfSDGaepqdhklTLEKVFQGLSLLEAKLKSVFTKHGLEKMaPIGDKYDPHEHELICHMPAGvGVQP 191
Cdd:PRK14160 117 LLPVLDNLERAAA--VEG--------SVEDLKKGIEMTVKQFKTSLEKLGVEEI-STEGEFDPNLHNAVMHVEDE-NYGE 184

                        170       180
                 ....*....|....*....|....*.
gi 157824222 192 GTVALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK14160 185 NEIVEVFQKGYKRGDKVIRYSMVKVA 210
PRK14146 PRK14146
heat shock protein GrpE; Provisional
 69-216 8.10e-07

heat shock protein GrpE; Provisional


Pssm-ID: 172635 [Multi-domain]  Cd Length: 215  Bit Score: 48.19  E-value: 8.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222  69 EKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTAECFSDGAEpqdhkltLEKVFQGLSL 148
Cdd:PRK14146  67 KKEIESLKDSWARERAEFQNFKRRSAQEFVSIRKEAVKSLVSGFLNPIDNLERVGATQNQSEE-------LKPFVEGVKM 139

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157824222 149 LEAKLKSVFTKHGLEKMAPIGDKYDPHEHELICHmPAGVGVQPGTVALVRQDGYKLH----GRTIRLAQVEV 216
Cdd:PRK14146 140 ILKEFYSVLEKSNVIRFDPKGEPFDPMSMEALSS-EEGDQYSEETVIDVYQAGYYYKenedKFTLRPARVRI 210
PRK14156 PRK14156
heat shock protein GrpE; Provisional
 41-217 5.59e-06

heat shock protein GrpE; Provisional


Pssm-ID: 237628 [Multi-domain]  Cd Length: 177  Bit Score: 45.21  E-value: 5.59e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222  41 EDCSSEDPPDGLGPSLAEQALRlKAVKLEKEVQDLTL----------RYQRAVADCENIRRRTQRCVEDAKIFGIQSFCK 110
Cdd:PRK14156   3 EEIKNEEVEEEVEATETEETVE-EVVEETPEKSELELaneradefenKYLRAHAEMQNIQRRANEERQQLQRYRSQDLAK 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222 111 DLVEVADILEKTAECfsDGaepqdhkLTlEKVFQGLSLLEAKLKSVFTKHGLEKMApiGDKYDPHEHELICHMPAGVGVQ 190
Cdd:PRK14156  82 AILPSLDNLERALAV--EG-------LT-DDVKKGLEMVQESLIQALKEEGVEEVA--VDSFDHNLHMAVQTLPADDEHP 149

                        170       180
                 ....*....|....*....|....*..
gi 157824222 191 PGTVALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK14156 150 ADSIAQVFQKGYKLHERLLRPAMVVVY 176
PRK14142 PRK14142
heat shock protein GrpE; Provisional
 47-216 1.08e-05

heat shock protein GrpE; Provisional


Pssm-ID: 237623  Cd Length: 223  Bit Score: 44.99  E-value: 1.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222  47 DPPDGLGPSlaeqalrlKAVKLEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTAECF 126
Cdd:PRK14142  32 DMPGGTAAA--------DAAHTEDKVAELTADLQRVQADFANYRKRALRDQQAAADRAKASVVSQLLGVLDDLERARKHG 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157824222 127 SDGAEPqdhkltlekvfqgLSLLEAKLKSVFTKHGLEKMAPIGDKYDPHEHELICHM-PAGVGVQPGTVALVRQdGYKLH 205
Cdd:PRK14142 104 DLESGP-------------LKSVADKLDSALTGLGLVAFGAEGEDFDPVLHEAVQHEgDGGQGSKPVIGTVMRQ-GYQLG 169

                        170
                 ....*....|.
gi 157824222 206 GRTIRLAQVEV 216
Cdd:PRK14142 170 EQVLRHALVGV 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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