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Conserved domains on  [gi|1477471287|ref|NP_001103581|]
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Gal_Lectin domain-containing protein precursor [Danio rerio]

Protein Classification

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List of domain hits

 Name Accession Description Interval E-value
Gal_Rha_Lectin_SUL-I-like cd22827
galactose/rhamnose binding lectin domain found in Toxopneustes pileolus rhamnose-binding ...
 32-123 6.83e-35

galactose/rhamnose binding lectin domain found in Toxopneustes pileolus rhamnose-binding lectin SUL-I and similar proteins; SUL-I is a galactose/rhamnose-binding lectin with mitogenic, chemotactic, and cytotoxic activity. These activities can be triggered by binding of the lectin to specific carbohydrate chains on target cells. SUL-I may be involved in self-defense against invading microorganisms. SUL-I is composed of three distinctive domains with a folding structure similar to galactose/rhamnose-binding lectin domain found in proteins such as mammalian latrophilins, Oncorhynchus keta L-rhamnose-binding lectins (CSLs), and Silurus asotus rhamnose-binding lectin (SAL). The family also includes Heliocidaris crassispina D-galactoside-specific lectin, also known as sea urchin egg lectin or SUEL, and Echinometra lucunter L-rhamnose-binding lectin ELEL-1, both of which contain only one galactose/rhamnose-binding lectin domain. SUEL binds D-galactoside. It may play an important role in the activation of eggs triggered by fertilization, or in their subsequent differentiation. The dimeric form is essential for hemagglutination activity of SUEL. ELEL-1 is a rhamnose-binding lectin that also binds alpha-D-melibiose, alpha-D-lactose, beta-D-lactose, methyl-alpha-D-galactopyranoside, methyl-beta-D--galactopyranoside and D-galactose, but not D-arabinose, L-fucose, D-glucose, D-mannose, D-maltose, D-sucrose, N-acetyl-D-galactosamine, N-acetyl-D-glucosamine, N-acetyl-D-mannosamine-D-xylose, or by glycoproteins orosomucoid, thyroglobulin, ovomucoid and porcine stomach mucin. It shows cation-independent hemagglutinating activity against rabbit and human erythrocytes. ELEL-1 agglutinates cells of Gram-positive bacterial species S. aureus but not those of Gram-negative E. coli.


:

Pssm-ID: 438684 [Multi-domain]  Cd Length: 89  Bit Score: 115.76  E-value: 6.83e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477471287  32 ATACEHSVLDLSCPDHTRIKILAANYGRTERRSCrnrPYGQLRNTHCYTPNAVFIVARRCNWRKRCSVPATNSVFSDPCV 111
Cdd:cd22827     1 KRVCEGQTLTISCPAGKVIDIVSANYGRTDSSTC---PSGGIKNTNCRASNSLSIVRNRCNGKRSCSVKASNSVFGDPCV 77

                          90
                  ....*....|..
gi 1477471287 112 GTYKYLRVKYCC 123
Cdd:cd22827    78 GTYKYLEVRYRC 89
 
Name Accession Description Interval E-value
Gal_Rha_Lectin_SUL-I-like cd22827
galactose/rhamnose binding lectin domain found in Toxopneustes pileolus rhamnose-binding ...
 32-123 6.83e-35

galactose/rhamnose binding lectin domain found in Toxopneustes pileolus rhamnose-binding lectin SUL-I and similar proteins; SUL-I is a galactose/rhamnose-binding lectin with mitogenic, chemotactic, and cytotoxic activity. These activities can be triggered by binding of the lectin to specific carbohydrate chains on target cells. SUL-I may be involved in self-defense against invading microorganisms. SUL-I is composed of three distinctive domains with a folding structure similar to galactose/rhamnose-binding lectin domain found in proteins such as mammalian latrophilins, Oncorhynchus keta L-rhamnose-binding lectins (CSLs), and Silurus asotus rhamnose-binding lectin (SAL). The family also includes Heliocidaris crassispina D-galactoside-specific lectin, also known as sea urchin egg lectin or SUEL, and Echinometra lucunter L-rhamnose-binding lectin ELEL-1, both of which contain only one galactose/rhamnose-binding lectin domain. SUEL binds D-galactoside. It may play an important role in the activation of eggs triggered by fertilization, or in their subsequent differentiation. The dimeric form is essential for hemagglutination activity of SUEL. ELEL-1 is a rhamnose-binding lectin that also binds alpha-D-melibiose, alpha-D-lactose, beta-D-lactose, methyl-alpha-D-galactopyranoside, methyl-beta-D--galactopyranoside and D-galactose, but not D-arabinose, L-fucose, D-glucose, D-mannose, D-maltose, D-sucrose, N-acetyl-D-galactosamine, N-acetyl-D-glucosamine, N-acetyl-D-mannosamine-D-xylose, or by glycoproteins orosomucoid, thyroglobulin, ovomucoid and porcine stomach mucin. It shows cation-independent hemagglutinating activity against rabbit and human erythrocytes. ELEL-1 agglutinates cells of Gram-positive bacterial species S. aureus but not those of Gram-negative E. coli.


Pssm-ID: 438684 [Multi-domain]  Cd Length: 89  Bit Score: 115.76  E-value: 6.83e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477471287  32 ATACEHSVLDLSCPDHTRIKILAANYGRTERRSCrnrPYGQLRNTHCYTPNAVFIVARRCNWRKRCSVPATNSVFSDPCV 111
Cdd:cd22827     1 KRVCEGQTLTISCPAGKVIDIVSANYGRTDSSTC---PSGGIKNTNCRASNSLSIVRNRCNGKRSCSVKASNSVFGDPCV 77

                          90
                  ....*....|..
gi 1477471287 112 GTYKYLRVKYCC 123
Cdd:cd22827    78 GTYKYLEVRYRC 89
Gal_Lectin pfam02140
Galactose binding lectin domain;
42-123 2.60e-30

Galactose binding lectin domain;


Pssm-ID: 460460 [Multi-domain]  Cd Length: 79  Bit Score: 103.91  E-value: 2.60e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477471287  42 LSCPDHTRIKILAANYGRTERRSCRNrpygQLRNTHCYTPNAVFIVARRCNWRKRCSVPATNSVF-SDPCVGTYKYLRVK 120
Cdd:pfam02140   1 LSCPPGKVISILFASYGRPDGTTCPS----FIQGTNCHSPNSLAIVSKACQGKNSCSVPASNSVFgGDPCPGTYKYLEVE 76


                  ...
gi 1477471287 121 YCC 123
Cdd:pfam02140  77 YKC 79
PLN03059 PLN03059
beta-galactosidase; Provisional
 42-123 4.13e-04

beta-galactosidase; Provisional


Pssm-ID: 166698 [Multi-domain]  Cd Length: 840  Bit Score: 38.83  E-value: 4.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477471287  42 LSCPDHTRI-KILAANYGrTERRSCrnrpyGQLRNTHCYTPNAVFIVARRCNWRKRCSVPATNSVF-SDPCVGTYKYLRV 119
Cdd:PLN03059  762 LWCPPGQKIsKIKFASFG-VPQGTC-----GSFREGSCHAHKSYDAFERNCIGKQSCSVTVAPEVFgGDPCPDSMKKLSV 835


                  ....
gi 1477471287 120 KYCC 123
Cdd:PLN03059  836 EAVC 839
 
Name Accession Description Interval E-value
Gal_Rha_Lectin_SUL-I-like cd22827
galactose/rhamnose binding lectin domain found in Toxopneustes pileolus rhamnose-binding ...
 32-123 6.83e-35

galactose/rhamnose binding lectin domain found in Toxopneustes pileolus rhamnose-binding lectin SUL-I and similar proteins; SUL-I is a galactose/rhamnose-binding lectin with mitogenic, chemotactic, and cytotoxic activity. These activities can be triggered by binding of the lectin to specific carbohydrate chains on target cells. SUL-I may be involved in self-defense against invading microorganisms. SUL-I is composed of three distinctive domains with a folding structure similar to galactose/rhamnose-binding lectin domain found in proteins such as mammalian latrophilins, Oncorhynchus keta L-rhamnose-binding lectins (CSLs), and Silurus asotus rhamnose-binding lectin (SAL). The family also includes Heliocidaris crassispina D-galactoside-specific lectin, also known as sea urchin egg lectin or SUEL, and Echinometra lucunter L-rhamnose-binding lectin ELEL-1, both of which contain only one galactose/rhamnose-binding lectin domain. SUEL binds D-galactoside. It may play an important role in the activation of eggs triggered by fertilization, or in their subsequent differentiation. The dimeric form is essential for hemagglutination activity of SUEL. ELEL-1 is a rhamnose-binding lectin that also binds alpha-D-melibiose, alpha-D-lactose, beta-D-lactose, methyl-alpha-D-galactopyranoside, methyl-beta-D--galactopyranoside and D-galactose, but not D-arabinose, L-fucose, D-glucose, D-mannose, D-maltose, D-sucrose, N-acetyl-D-galactosamine, N-acetyl-D-glucosamine, N-acetyl-D-mannosamine-D-xylose, or by glycoproteins orosomucoid, thyroglobulin, ovomucoid and porcine stomach mucin. It shows cation-independent hemagglutinating activity against rabbit and human erythrocytes. ELEL-1 agglutinates cells of Gram-positive bacterial species S. aureus but not those of Gram-negative E. coli.


Pssm-ID: 438684 [Multi-domain]  Cd Length: 89  Bit Score: 115.76  E-value: 6.83e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477471287  32 ATACEHSVLDLSCPDHTRIKILAANYGRTERRSCrnrPYGQLRNTHCYTPNAVFIVARRCNWRKRCSVPATNSVFSDPCV 111
Cdd:cd22827     1 KRVCEGQTLTISCPAGKVIDIVSANYGRTDSSTC---PSGGIKNTNCRASNSLSIVRNRCNGKRSCSVKASNSVFGDPCV 77

                          90
                  ....*....|..
gi 1477471287 112 GTYKYLRVKYCC 123
Cdd:cd22827    78 GTYKYLEVRYRC 89
Gal_Rha_Lectin_RBL_rpt2 cd22836
second galactose/rhamnose binding lectin domain found in Silurus asotus rhamnose-binding ...
 32-123 3.51e-34

second galactose/rhamnose binding lectin domain found in Silurus asotus rhamnose-binding lectin (RBL) and similar proteins; RBL, also known as Silurus asotus (catfish) roe lectin (SAL), is a lectin that binds L-rhamnose. It also binds monosaccharides possessing steric similarity to the hydroxyl group orientation at C2 and C4 of the pyranose ring structure of L-rhamnose, such as L-mannose and L-lyxose. RBL does not require a Ca2+ ion or free thiol group for its agglutination activity. RBL contains three galactose/rhamnose-binding lectin domains. This model corresponds to the second one.


Pssm-ID: 438693 [Multi-domain]  Cd Length: 95  Bit Score: 113.92  E-value: 3.51e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477471287  32 ATACEHSVLDLSCpDHTRIKILAANYGRTERRSC-RNRPYGQLRNTHCYTPNAVFIVARRCNWRKRCSVPATNSVFSDPC 110
Cdd:cd22836     4 SVTCEGGYAVLKC-GSGVIQIISANYGRTDSTTCsAGRPASQVQNTNCYASNSLAIVSQSCNGKKSCTVSASNSVFSDPC 82

                          90
                  ....*....|...
gi 1477471287 111 VGTYKYLRVKYCC 123
Cdd:cd22836    83 VGTYKYLYVTYSC 95
Gal_Rha_Lectin_LPHNs cd22826
galactose/rhamnose binding lectin domain found in latrophilins; Latrophilins, also called ...
 34-123 7.73e-31

galactose/rhamnose binding lectin domain found in latrophilins; Latrophilins, also called lectomedins or latrotoxin receptors, belong to Group I adhesion GPCRs, which also include ETL (EGF-TM7-latrophilin-related protein). These receptors are a member of the adhesion family (subclass B2) that belongs to the class B GPCRs. Three subtypes of latrophilins have been identified: latrophilin-1 (LPHN1), Latrophilin-2 (LPHN2), and Latrophilin-3 (LPHN3). The LPHN1 is a brain-specific calcium-independent receptor of alpha-latrotoxin, a potent presynaptic neurotoxin from the venom of the black widow spider that induces massive neurotransmitter release from sensory and motor neurons as well as endocrine cells, leading to nerve-terminal degeneration. LPHN2 and LPHN3, although sharing strong sequence homology to LPHN1, do not bind alpha-latrotoxin. While LPHN3 is also brain specific, LPHN2, is ubiquitously distributed. The endogenous ligands for these two receptors are unknown. All members in this family contain a galactose/rhamnose-binding lectin domain at N-terminus.


Pssm-ID: 438683 [Multi-domain]  Cd Length: 92  Bit Score: 105.48  E-value: 7.73e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477471287  34 ACEHSVLDLSCPDHTRIKILAANYGRTERRSCRNRPygQLRNTHCYTPNAVFIVARRCNWRKRCSVPATNSVFSDPCVGT 113
Cdd:cd22826     5 ACEGYKIRLRCPGSDVIMIESANYGRTDSSTCPSDP--NMTDTNCYLPDALAIVSQRCNNRTRCNVRADSSFFPDPCPGT 82

                          90
                  ....*....|
gi 1477471287 114 YKYLRVKYCC 123
Cdd:cd22826    83 FKYLEVIYEC 92
Gal_Lectin pfam02140
Galactose binding lectin domain;
42-123 2.60e-30

Galactose binding lectin domain;


Pssm-ID: 460460 [Multi-domain]  Cd Length: 79  Bit Score: 103.91  E-value: 2.60e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477471287  42 LSCPDHTRIKILAANYGRTERRSCRNrpygQLRNTHCYTPNAVFIVARRCNWRKRCSVPATNSVF-SDPCVGTYKYLRVK 120
Cdd:pfam02140   1 LSCPPGKVISILFASYGRPDGTTCPS----FIQGTNCHSPNSLAIVSKACQGKNSCSVPASNSVFgGDPCPGTYKYLEVE 76


                  ...
gi 1477471287 121 YCC 123
Cdd:pfam02140  77 YKC 79
Gal_Rha_Lectin_SML_rpt2 cd22835
second galactose/rhamnose binding lectin domain found in Scomberomorus niphonius ...
 34-123 7.59e-30

second galactose/rhamnose binding lectin domain found in Scomberomorus niphonius L-rhamnose-binding lectin (SML) and similar proteins; SML is a rhamnose-binding lectin that also binds melibiose, raffinose, D-galactose, L-arabinose, D-fucose, maltose and D-glucose with decreasing affinity. It does not bind D-arabinose, L-fucose, lactose, xylose or 2-deoxy-D-galactose. SML shows strong hemagglutinating activity against rabbit erythrocytes. SML contains two tandem galactose/rhamnose-binding lectin domains. This model corresponds to the second one.


Pssm-ID: 438692 [Multi-domain]  Cd Length: 92  Bit Score: 103.15  E-value: 7.59e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477471287  34 ACEHSVLDLSCPDHTRIKILAANYGRTERRSC-RNRPYGQLRNTHCYTPNAvfIVARRCNWRKRCSVPATNSVFSDPCVG 112
Cdd:cd22835     4 ACEGSLAHLKCDEGQVISVYGADYGRRDKTTCsFGRPPSQIQNVECSNPTD--KVAERCNGKNSCSIKASNSVFGDPCVG 81

                          90
                  ....*....|.
gi 1477471287 113 TYKYLRVKYCC 123
Cdd:cd22835    82 TYKYLEVAYTC 92
Gal_Rha_Lectin cd22823
Galactose/rhamnose-binding lectin domain; Galactose/rhamnose-binding lectin domain is formed ...
 32-123 9.82e-29

Galactose/rhamnose-binding lectin domain; Galactose/rhamnose-binding lectin domain is formed from a four-stranded antiparallel beta-sheet which packs against an alpha-helix. It was originally described as galactose-binding lectin domain since it was found in a galactose-binding sea urchin egg lectin (SUEL). SUEL was first isolated as a D-galactoside binding lectin, it was later shown that it binds to L-rhamnose preferentially. Galactose/rhamnose-binding lectin domain is also found in many rhamnose-binding lectins, such as Oncorhynchus keta L-rhamnose-binding lectins (CSLs) and Silurus asotus rhamnose-binding lectin (SAL). In addition, the superfamily includes many SUEL/CSLs/SAL homologous proteins, such as plant beta-galactosidases, mammalian latrophilins, Caenorhabditis elegans protein EVA-1 and its homolog, human protein EVA-1 homolog C (also known as C21orf63). Due to the lack of galactose/rhamnose-binding key residues, some superfamily members may not form a binding pocket for galactose/rhamnose. Therefore, they are unlikely to act as galactose/rhamnose-binding lectins.


Pssm-ID: 438682 [Multi-domain]  Cd Length: 91  Bit Score: 100.27  E-value: 9.82e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477471287  32 ATACEHSVLDLSCPDHTRIKILAANYGRTERRSCrNRPYGQLRNTHCYTPNAVFIVARRCNWRKRCSVPATNSVFSDPCV 111
Cdd:cd22823     1 ATACEGETLTLSCPSGQVIKILSAFYGRTDGTTC-CCGPNNTSDTNCCSPDVLDIVKELCDGKQSCSVPASNSVFGDPCP 79

                          90
                  ....*....|..
gi 1477471287 112 GTYKYLRVKYCC 123
Cdd:cd22823    80 GTSKYLEVTYTC 91
Gal_Rha_Lectin_dCirl cd22830
galactose/rhamnose binding lectin domain found in Drosophila melanogaster Latrophilin Cirl and ...
 32-123 1.04e-25

galactose/rhamnose binding lectin domain found in Drosophila melanogaster Latrophilin Cirl and similar proteins; Latrophilin Cirl (calcium-independent receptor for latrotoxin) is an adhesion-type G-protein-coupled receptor (aGPCR) that acts as a molecular sensor and signal transducer that detects and converts mechanical stimuli into a metabotropic response. It functions in mechanosensory neurons by modulating ionotropic receptor currents, the initiating step of cellular mechanosensation. The model corresponds to a galactose/rhamnose-binding lectin domain found at the N-terminus of Latrophilin Cirl.


Pssm-ID: 438687 [Multi-domain]  Cd Length: 92  Bit Score: 92.69  E-value: 1.04e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477471287  32 ATACEHSVLDLSCPDHTRIKILAANYGRTERRSCRnrPYGQLR-NTHCYTPNAVFIVARRCNWRKRCSVPATNSVFSDPC 110
Cdd:cd22830     2 AYACEGSQLTLECEDGTVIRIIRANYGRFSIAICN--DHGNTDwSVNCMSPRSLRVVQERCDGKRSCSIPASSSVFGDPC 79

                          90
                  ....*....|...
gi 1477471287 111 VGTYKYLRVKYCC 123
Cdd:cd22830    80 PGTPKYLEVHYQC 92
Gal_Rha_Lectin_CSL3_rpt1_rpt2-like cd22832
first and second galactose/rhamnose binding lectin domain found in Oncorhynchus keta ...
 31-123 6.10e-25

first and second galactose/rhamnose binding lectin domain found in Oncorhynchus keta L-rhamnose-binding lectin CSL3 and similar proteins; The family includes a group of L-rhamnose-binding lectins, such as Oncorhynchus keta CSL1-3. CSL1 has hemagglutinating activity towards rabbit erythrocytes, but not human type B erythrocytes. CSL2 has hemagglutinating activity towards rabbit erythrocytes and human type B erythrocytes. CSL3 has hemagglutinating activity towards rabbit erythrocytes, human type A erythrocytes, human type B erythrocytes, human type O erythrocytes, and sheep erythrocytes. Their hemagglutinating activities are inhibited by smooth-type lipopolysaccharide (LPS) from different bacterial species. Members in this family contain two tandem galactose-binding lectin domains. This model corresponds to the first and second galactose/rhamnose-binding lectin domains found in Oncorhynchus keta CSL3, as well as the second galactose/rhamnose-binding lectin domain found in Oncorhynchus keta CSL2.


Pssm-ID: 438689 [Multi-domain]  Cd Length: 94  Bit Score: 90.63  E-value: 6.10e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477471287  31 IATACEHSVLDLSCpDHTRIKILAANYGRTERRSCR-NRPYGQLRNTHCYTPNAVFIVARRCNWRKRCSVPATNSVFSDP 109
Cdd:cd22832     2 SSITCEGSDAQLDC-DGGKIRIQRANYGRRDHDVCSiGRPANQLTNTNCLSQSTTSKMAERCDGKSQCIVPASNSVFGDP 80

                          90
                  ....*....|....
gi 1477471287 110 CVGTYKYLRVKYCC 123
Cdd:cd22832    81 CVGTYKYLDVAYTC 94
Gal_Rha_Lectin_CSL1_rpt2 cd22834
second galactose/rhamnose binding lectin domain found in Oncorhynchus keta CSL1 and similar ...
 35-123 1.25e-24

second galactose/rhamnose binding lectin domain found in Oncorhynchus keta CSL1 and similar proteins; The family includes a group of L-rhamnose-binding lectins, such as Oncorhynchus keta CSL1. CSL1 has hemagglutinating activity towards rabbit erythrocytes, but not human type B erythrocytes. Its hemagglutinating activity is inhibited by smooth-type lipopolysaccharide (LPS) from Klebsiella pneumoniae, Escherichia coli K-235, Shigella flexneri 1A, Aeromonas salmonicida and Salmonella minnesota and rough-type LPS from S. flexneri, but not by rough-type LPS from E. coli K12 and E. coli EH100. CSL1 agglutinates E. coli K12 and Bacillus subtilis. CSL1 contains two tandem galactose-binding lectin domains. This model corresponds to the second one.


Pssm-ID: 438691 [Multi-domain]  Cd Length: 95  Bit Score: 89.82  E-value: 1.25e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477471287  35 CEHSVLDLSCpDHTRIKILAANYGRTERRSCRN-RPYGQLRNTHCYTPNAVFIVARRCNWRKRCSVPATNSVFsDPCVGT 113
Cdd:cd22834     8 CEGSPVSLDC-GPDVIKIYDANYGRRDSTTCSHgRPESQLTNTNCYLPETTKVMSERCNGKSLCDLLASNVVT-DPCYGT 85

                          90
                  ....*....|
gi 1477471287 114 YKYLRVKYCC 123
Cdd:cd22834    86 YKYLEVSYSC 95
Gal_Rha_Lectin_LPHN3 cd22846
galactose/rhamnose binding lectin domain found in latrophilin-3 and similar proteins; ...
 34-123 2.83e-23

galactose/rhamnose binding lectin domain found in latrophilin-3 and similar proteins; Latrophilin-3 (LPHN3), also called adhesion G protein-coupled receptor L3 (ADGRL3), or calcium-independent alpha-latrotoxin receptor 3 (CIRL-3), or lectomedin-3, is a brain-specific calcium-independent receptor that plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. It is involved in the development of glutamatergic synapses in the cortex. This model corresponds to a galactose/rhamnose-binding lectin domain found at the N-terminus of LPHN3.


Pssm-ID: 438703 [Multi-domain]  Cd Length: 99  Bit Score: 86.69  E-value: 2.83e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477471287  34 ACEHSVLDLSCPDHTRIKILAANYGRTERRSCRNRPyGQLRNTHCYTPNAVFIVARRCNWRKRCSVPATNSVFSDPCVGT 113
Cdd:cd22846     7 SCESYPIELRCPGTDVIMIESANYGRTDDKICDSDP-AQMENIRCYLPDAYKIMSQRCNNRTQCAVVAGPDVFPDPCPGT 85

                          90
                  ....*....|
gi 1477471287 114 YKYLRVKYCC 123
Cdd:cd22846    86 YKYLEVQYEC 95
Gal_Rha_Lectin_LPHN1 cd22844
galactose/rhamnose binding lectin domain found in latrophilin-1 and similar proteins; ...
 34-123 1.53e-22

galactose/rhamnose binding lectin domain found in latrophilin-1 and similar proteins; Latrophilin-1 (LPHN1), also called adhesion G protein-coupled receptor L1 (ADGRL1), or calcium-independent alpha-latrotoxin receptor 1 (CIRL-1), or lectomedin-2, is a brain-specific calcium-independent receptor that mediates the effect of alpha-latrotoxin, a potent presynaptic neurotoxin from the venom of the black widow spider that induces massive neurotransmitter release from sensory and motor neurons as well as endocrine cells, leading to nerve-terminal degeneration. This model corresponds to a galactose/rhamnose-binding lectin domain found at the N-terminus of LPHN1.


Pssm-ID: 438701 [Multi-domain]  Cd Length: 97  Bit Score: 84.72  E-value: 1.53e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477471287  34 ACEHSVLDLSCPDHTRIKILAANYGRTERRSCRNRPYgQLRNTHCYTPNAVFIVARRCNWRKRCSVPATNSVFSDPCVGT 113
Cdd:cd22844     6 ACEGYPIELRCPGSDVIMVENANYGRTDDKICDADPF-QMENVQCYLPDAFKIMSQRCNNRTQCVVVAGSDAFPDPCPGT 84

                          90
                  ....*....|
gi 1477471287 114 YKYLRVKYCC 123
Cdd:cd22844    85 YKYLEVQYDC 94
Gal_Rha_Lectin_LPHN2 cd22845
galactose/rhamnose binding lectin domain found in latrophilin-2 and similar proteins; ...
 34-123 6.21e-22

galactose/rhamnose binding lectin domain found in latrophilin-2 and similar proteins; Latrophilin-2 (LPHN2), also called adhesion G protein-coupled receptor L2 (ADGRL2), or calcium-independent alpha-latrotoxin receptor 2 (CIRL-2), or latrophilin homolog 1 (LPHH1), or lectomedin-1, is ubiquitously distributed calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. It is probably implicated in the regulation of exocytosis. This model corresponds to a galactose/rhamnose-binding lectin domain found at the N-terminus of LPHN2.


Pssm-ID: 438702 [Multi-domain]  Cd Length: 97  Bit Score: 83.14  E-value: 6.21e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477471287  34 ACEHSVLDLSCPDHTRIKILAANYGRTERRSCRNRPYgQLRNTHCYTPNAVFIVARRCNWRKRCSVPATNSVFSDPCVGT 113
Cdd:cd22845     6 SCEGYPIDLRCPGSDVIMIESANYGRTDDKICDADPF-QMENTDCYLPDAYKIMTQRCNNRTQCIVVTGSDVFPDPCPGT 84

                          90
                  ....*....|
gi 1477471287 114 YKYLRVKYCC 123
Cdd:cd22845    85 YKYLEVQYEC 94
Gal_Rha_Lectin_REJ3 cd22841
galactose/rhamnose binding lectin domain found in Strongylocentrotus purpuratus receptor for ...
 29-123 1.94e-20

galactose/rhamnose binding lectin domain found in Strongylocentrotus purpuratus receptor for egg jelly 3 protein (REJ3) and similar proteins; REJ3 is a polycystin-1 protein (components of non-selective cation channels) that is cleaved at the GPS (G-protein-coupled receptor proteolytic site) domain and localizes to the acrosomal region of sea urchin sperm. REJ3 is a multidomain protein containing only one galactose/rhamnose-binding lectin domain at its N-terminus.


Pssm-ID: 438698 [Multi-domain]  Cd Length: 92  Bit Score: 79.05  E-value: 1.94e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477471287  29 TDIATACEHSVLDLSCPDhTRIKILAANYGRTERRSCrnrPYGQ-LRNTHCYTPNAVFIVARRCNWRKRCSVPATNSVFS 107
Cdd:cd22841     1 TETFIVCEGDTDVIDCGN-GVINIHSAVYGRTDSTTC---SHDQsVSNTNCHSDDSVNILSACCNGQSQCTVTATNSIFG 76

                          90
                  ....*....|....*.
gi 1477471287 108 DPCVGTYKYLRVKYCC 123
Cdd:cd22841    77 DPCPGTYKYLNVTYTC 92
Gal_Rha_Lectin_EVA1_EVA1C_rpt2 cd22829
second galactose/rhamnose binding lectin domain found in Caenorhabditis elegans protein EVA-1, ...
 30-123 4.41e-20

second galactose/rhamnose binding lectin domain found in Caenorhabditis elegans protein EVA-1, human protein EVA-1 homolog C and similar proteins; The family includes Caenorhabditis elegans protein EVA-1 and its homologs, such as human protein EVA-1 homolog C (also known as C21orf63). EVA-1 functions as an UNC-40 coreceptor to enhance attraction to the MADD-4 guidance cue in C. elegans. It also acts as a receptor for slt-1 and is required for the guidance of the AVM pioneer axon to the ventral nerve cord. Human C21orf63 is a type-1 transmembrane heparin-binding protein. Members in this family contain two tandem galactose/rhamnose-binding lectin domains. This model corresponds to the second one. Due to the lack of rhamnose-binding key residues, the second galactose/rhamnose-binding domains of EVA-1 does not form a binding pocket for rhamnose.


Pssm-ID: 438686 [Multi-domain]  Cd Length: 99  Bit Score: 78.46  E-value: 4.41e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477471287  30 DIATACEHSVLDLSCPDHTRIKILAANYGRTERRS--CRNRPYGQLRNThCYTPNAVFIVARRCNWRKRCSVPATNSVFS 107
Cdd:cd22829     2 KSKVVCEGEKLRLSCKPSSRLAIYSASYGRTLEGSveCPSTPKGDPDEE-CLSDVALETVMKRCHGKRRCSLTADSETFG 80

                          90
                  ....*....|....*..
gi 1477471287 108 DPCV-GTYKYLRVKYCC 123
Cdd:cd22829    81 DPCPpGVRKYLKVVYTC 97
Gal_Rha_Lectin_CSL1-2_RBL_SML_rpt1 cd22833
first galactose/rhamnose binding lectin domain found in Oncorhynchus keta CSL1-2, Silurus ...
 33-123 6.17e-20

first galactose/rhamnose binding lectin domain found in Oncorhynchus keta CSL1-2, Silurus asotus RBL, Scomberomorus niphonius SML and similar proteins; The family includes a group of L-rhamnose-binding lectins, such as Oncorhynchus keta CSL1 and CSL2. CSL1 has hemagglutinating activity towards rabbit erythrocytes, but not human type B erythrocytes. CSL2 has hemagglutinating activity towards rabbit erythrocytes and human type B erythrocytes. Their hemagglutinating activities are inhibited by smooth-type lipopolysaccharide (LPS) from different bacterial species. The family also includes Silurus asotus rhamnose-binding lectin (RBL) and Scomberomorus niphonius L-rhamnose-binding lectin (SML). RBL, also known as Silurus asotus (catfish) roe lectin (SAL), is a lectin that binds L-rhamnose. It also binds monosaccharides possessing steric similarity to the hydroxyl group orientation at C2 and C4 of the pyranose ring structure of L-rhamnose, such as L-mannose and L-lyxose. RBL does not require a Ca2+ ion or free thiol group for its agglutination activity. SML is a rhamnose-binding lectin that also binds melibiose, raffinose, D-galactose, L-arabinose, D-fucose, maltose, and D-glucose with decreasing affinity. It does not bind D-arabinose, L-fucose, lactose, xylose or 2-deoxy-D-galactose. SML shows strong hemagglutinating activity against rabbit erythrocytes. CSL1-2 and SML contain two tandem galactose/rhamnose-binding lectin domains. RBL contains three galactose/rhamnose-binding lectin domains. This model corresponds to the first one.


Pssm-ID: 438690 [Multi-domain]  Cd Length: 97  Bit Score: 78.07  E-value: 6.17e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477471287  33 TACE-HSVLDLSCpDHTRIKILAANYGRTERRSCR-NRPYGQLRNTHCYTPNAVFIVARRCNWRKRCSVPATNSVFSDPC 110
Cdd:cd22833     4 TTCDgNNVHRLSC-DTGVINVQSALYGRTDSETCSeGRPPEQLTNTQCSQSGTLDLLKNRCDGKKVCELNTNDFRTSDPC 82

                          90
                  ....*....|...
gi 1477471287 111 VGTYKYLRVKYCC 123
Cdd:cd22833    83 PGTYKYLQTNYTC 95
Gal_Rha_Lectin_RBL_rpt3 cd22837
third galactose/rhamnose binding lectin domain found in Silurus asotus rhamnose-binding lectin ...
 35-123 8.56e-18

third galactose/rhamnose binding lectin domain found in Silurus asotus rhamnose-binding lectin (RBL) and similar proteins; RBL, also known as Silurus asotus (catfish) roe lectin (SAL), is a lectin that binds L-rhamnose. It also binds monosaccharides possessing steric similarity to the hydroxyl group orientation at C2 and C4 of the pyranose ring structure of L-rhamnose, such as L-mannose and L-lyxose. RBL does not require a Ca2+ ion or free thiol group for its agglutination activity. RBL contains three galactose/rhamnose-binding lectin domains. This model corresponds to the third one.


Pssm-ID: 438694 [Multi-domain]  Cd Length: 87  Bit Score: 72.07  E-value: 8.56e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477471287  35 CEHSVLDLSCpDHTRIKILAANYGRTERRSCrnrPYGQLRNTHCYTPNAVFIVARrCNWRKRCSVPATNSVFSDPCVGTY 114
Cdd:cd22837     4 CENDSATITC-SPETINVISAFYGRTDSTTC---SHGRPSTTNCSSDTLAYIRAL-CQGKQTCTLQASNSVFGDPCPGTY 78


                  ....*....
gi 1477471287 115 KYLRVKYCC 123
Cdd:cd22837    79 KYLRITYSC 87
Gal_Rha_Lectin_LAT1 cd22839
galactose/rhamnose binding lectin domain found in Caenorhabditis elegans latrophilin-like ...
 33-123 4.44e-15

galactose/rhamnose binding lectin domain found in Caenorhabditis elegans latrophilin-like protein 1 (LAT1) and similar proteins; LAT1 plays a role in the establishment of anterior-posterior polarity in tissues during embryogenesis. It is required for the alignment of the mitotic spindles and division planes. It may have a role in cell death events and play an essential role in normal defection and oocyte fertilization. LAT1 is involved in sperm function. it operates in pharyngeal pumping during feeding. LAT1 contains a galactose/rhamnose binding lectin domain at the N-terminus.


Pssm-ID: 438696 [Multi-domain]  Cd Length: 95  Bit Score: 65.52  E-value: 4.44e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477471287  33 TACEHSVLDLSCPDHTRIKILAANYGRTERRSCrNRPYGQLRNTHCYTPNAVFIVARRCNWRKRCSVPATNSVF-SDPCV 111
Cdd:cd22839     5 IICEGDVANLSCPEGKYISIRLANYGRFSLGVC-NPSNNIDLSTTCQNDKTLPILQKSCDGKSECSFVVSNKFFfEDPCP 83

                          90
                  ....*....|..
gi 1477471287 112 GTYKYLRVKYCC 123
Cdd:cd22839    84 GTPKYLEATYSC 95
Gal_Rha_Lectin_nemgal cd22838
galactose/rhamnose binding lectin domain found in Hydra vulgaris nematogalectin and similar ...
 32-124 5.46e-15

galactose/rhamnose binding lectin domain found in Hydra vulgaris nematogalectin and similar proteins; Nematogalectin, also called nemgal, is a nematocyst protein with an N-terminal GlyXY domain and a galactose/rhamnose binding lectin domain. There are two nematogalectins, A and B, in Hydra, and they are the products of alternative splicing. They are major components of the nematocyst tubule. Nematogalectin functions as a trimer that could bind to multiple chondroitin glycosaminoglycan molecules and stabilize the chondroitin proteoglycan layer.


Pssm-ID: 438695 [Multi-domain]  Cd Length: 100  Bit Score: 65.37  E-value: 5.46e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477471287  32 ATACEHSVLDLSCPDHTRIKILAANYGRTERRSCRNRPYGQLRNTHCYT--PNAVFIVARRCNWRKRCSVPATNSVFSDP 109
Cdd:cd22838     4 AIACEGEKLWLQCPQYELIKIKSAFWGRDDKKTCPHPPPGLPSNKMCETdeENVKKKVNDQCQGEQACEVVASNIFFDDT 83

                          90
                  ....*....|....*.
gi 1477471287 110 -CVGTYKYLRVKYCCR 124
Cdd:cd22838    84 iCPDVYKYLKVKYECI 99
Gal_Rha_Lectin_EVA1_EVA1C_rpt1 cd22828
first galactose/rhamnose binding lectin domain found in Caenorhabditis elegans protein EVA-1, ...
 32-124 7.79e-15

first galactose/rhamnose binding lectin domain found in Caenorhabditis elegans protein EVA-1, human protein EVA-1 homolog C and similar proteins; The family includes Caenorhabditis elegans protein EVA-1 and its homologs, such as human protein EVA-1 homolog C (also known as C21orf63). EVA-1 functions as an UNC-40 coreceptor to enhance attraction to the MADD-4 guidance cue in C. elegans. It also acts as a receptor for slt-1 and is required for the guidance of the AVM pioneer axon to the ventral nerve cord. Human C21orf63 is a type-1 transmembrane heparin-binding protein. Both human C21orf63 is a type-1 transmembrane heparin-binding protein. Members in this family contain two tandem galactose/rhamnose-binding lectin domains. This model corresponds to the first one.


Pssm-ID: 438685 [Multi-domain]  Cd Length: 105  Bit Score: 64.99  E-value: 7.79e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477471287  32 ATACEHSVLDLSCPDHTRIKILAANYGRTERRS--CRNRP----YGQLRNTHCYTPNAVFIVARRCNWRKRCSVPATNSV 105
Cdd:cd22828     5 RHACDGEELTLRCPPNTTISIQSAFYGRSVPSAqlCPSQSgpasSTSLEDTNCLAPTALQKVVEECQKKRSCRLLVSSRT 84

                          90       100
                  ....*....|....*....|
gi 1477471287 106 F-SDPCVGTYKYLRVKYCCR 124
Cdd:cd22828    85 FgLDPCPGTSKYLEVAYKCR 104
Gal_Rha_Lectin_BGal cd22842
galactose/rhamnose binding lectin domain found in plant beta-galactosidases and similar ...
 37-119 5.28e-13

galactose/rhamnose binding lectin domain found in plant beta-galactosidases and similar proteins; The family represents a group of plant beta-galactosidases (BGals), which belong to glycoside hydrolase family 35. They have a C-terminal domain homologous to animal galactose and rhamnose-binding lectins. BGals (EC 3.2.1.23), also called Exo-(1->4)-beta-D-galactanase, or lactase, catalyze hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. Some family members contain more than one galactose/rhamnose binding lectin domain. Due to the lack of rhamnose-binding key residues, the galactose/rhamnose-binding lectin domains of BGals do not form a binding pocket for rhamnose. Therefore, BGals are unlikely to act as rhamnose-binding lectins.


Pssm-ID: 438699 [Multi-domain]  Cd Length: 91  Bit Score: 59.99  E-value: 5.28e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477471287  37 HSVLDLSCPDHTRI-KILAANYGrTERRSCRNRPYGQlrnthCYTPNAVFIVARRCNWRKRCSVPATNSV-FSDPCVGTY 114
Cdd:cd22842     9 GSTLTLSCPAGQVIsSIDFASYG-TPTGTCGSFSKGS-----CHAPNSLSVVEKACLGKNSCSIPASNSVfFGDPCPGTT 82


                  ....*
gi 1477471287 115 KYLRV 119
Cdd:cd22842    83 KRLAV 87
Gal_Rha_Lectin_LAT2 cd22840
galactose/rhamnose binding lectin domain found in Caenorhabditis elegans latrophilin-like ...
 34-123 2.13e-11

galactose/rhamnose binding lectin domain found in Caenorhabditis elegans latrophilin-like protein 2 (LAT2) and similar proteins; LAT2 may have a role in pharyngeal pumping during feeding. It contains a galactose/rhamnose binding lectin domain at the N-terminal region. Due to the lack of rhamnose-binding key residues, the galactose/rhamnose-binding domains of LAT2 does not form a binding pocket for rhamnose. Therefore, LAT2 is unlikely to act as a rhamnose-binding lectin.


Pssm-ID: 438697 [Multi-domain]  Cd Length: 96  Bit Score: 55.88  E-value: 2.13e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477471287  34 ACEHSVLDLSCPDHTRIKILAANYGRTERRS-CRNrpYGQLRNTHCYTPNAVFIVARRCNWRKRCSVPATNSVFS-DPCV 111
Cdd:cd22840     6 ACEGDPFEISCPSGQRIKVDYASYGAIGTRStCGD--SVSPAGETCSAPNSLQTMRQRCQGRQSCEIRVLNSLFPnDPCP 83

                          90
                  ....*....|...
gi 1477471287 112 GTY-KYLRVKYCC 123
Cdd:cd22840    84 GTSkKYLEYRYRC 96
Gal_Rha_Lectin-like_P113 cd22843
galactose/rhamnose binding lectin-like domain found in Plasmodium falciparum P113 and similar ...
 32-123 1.12e-07

galactose/rhamnose binding lectin-like domain found in Plasmodium falciparum P113 and similar proteins; P113 is an abundant glycosylphosphatidylinositol (GPI)-anchored merozoite surface protein that tethers the RH5:CyRPA:RIPR complex to the merozoite surface. The N-terminal region of P113 contains two closely interacting domains, which resemble the galactose/rhamnose-binding lectin domains found in proteins such as sea urchin egg lectin (SUEL), plant beta-galactosidases, mammalian latrophilins, and catfish rhamnose-binding lectin (SAL) eggs. Due to the lack of rhamnose-binding key residues, the galactose/rhamnose binding lectin-like domains of P113 do not form a binding pocket for rhamnose. Therefore, P113 is unlikely to act as a rhamnose-binding lectin. This model corresponds to galactose/rhamnose binding lectin-like domain of P113.


Pssm-ID: 438700 [Multi-domain]  Cd Length: 89  Bit Score: 46.28  E-value: 1.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477471287  32 ATACEHSVLDLSCPDHTRIKILAANYGRTERRSCrnrPYGQLRNTHCytpNAVFIVARRCNWRKRCSVPATNSVFSDPCV 111
Cdd:cd22843     4 AFVCFGQEVTIHCPGDGNISIKSATYGYNNSNVC---IYCNSFNCDK---DITSPVNKKCCGKNTCVLTVSDILEGNPCG 77

                          90
                  ....*....|..
gi 1477471287 112 GTYKYLRVKYCC 123
Cdd:cd22843    78 IGNSYIRVVYTC 89
PLN03059 PLN03059
beta-galactosidase; Provisional
 42-123 4.13e-04

beta-galactosidase; Provisional


Pssm-ID: 166698 [Multi-domain]  Cd Length: 840  Bit Score: 38.83  E-value: 4.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477471287  42 LSCPDHTRI-KILAANYGrTERRSCrnrpyGQLRNTHCYTPNAVFIVARRCNWRKRCSVPATNSVF-SDPCVGTYKYLRV 119
Cdd:PLN03059  762 LWCPPGQKIsKIKFASFG-VPQGTC-----GSFREGSCHAHKSYDAFERNCIGKQSCSVTVAPEVFgGDPCPDSMKKLSV 835


                  ....
gi 1477471287 120 KYCC 123
Cdd:PLN03059  836 EAVC 839
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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