NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|161016765|ref|NP_001104292|]
View 

putative ATP-dependent RNA helicase TDRD12 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Tudor_TDRD12_rpt1 cd20434
first Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; ...
 4-165 4.98e-97

first Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the first/N-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


:

Pssm-ID: 410505  Cd Length: 164  Bit Score: 286.24  E-value: 4.98e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016765   4 LLVLKIEDPGCFWVIIKGCSPFL-DHDVDYQKLNSAMNDFYNSTCQDIE-IKPLTLEEGQVCVVYCEELKCWCRAIVKSI 81
Cdd:cd20434    1 IQVLKIEDPGCFWGRILKGSGDLvVNPEEYENLQDEMNQFYHKGYKDVEeIKPSTLEEGQVCVVFCEELKCWCRAVVESL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016765  82 TSSADQYLAECFLVDFAKNIPVKSKNIRVVVESFMQLPYRAKKFSLYCTKPVTLHIDFCRDSTDIVPAKKWDNAAIQYFQ 161
Cdd:cd20434   81 MSSADDYLAECFLVDYAKYIPVKSKDIRVALEAFMKLPYRAKKFRLYGIKPVTLHVDLCEDKAKIVPARKWDSAAIQYFQ 160


                 ....
gi 161016765 162 NLLK 165
Cdd:cd20434  161 NLLK 164
 
Name Accession Description Interval E-value
Tudor_TDRD12_rpt1 cd20434
first Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; ...
 4-165 4.98e-97

first Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the first/N-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410505  Cd Length: 164  Bit Score: 286.24  E-value: 4.98e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016765   4 LLVLKIEDPGCFWVIIKGCSPFL-DHDVDYQKLNSAMNDFYNSTCQDIE-IKPLTLEEGQVCVVYCEELKCWCRAIVKSI 81
Cdd:cd20434    1 IQVLKIEDPGCFWGRILKGSGDLvVNPEEYENLQDEMNQFYHKGYKDVEeIKPSTLEEGQVCVVFCEELKCWCRAVVESL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016765  82 TSSADQYLAECFLVDFAKNIPVKSKNIRVVVESFMQLPYRAKKFSLYCTKPVTLHIDFCRDSTDIVPAKKWDNAAIQYFQ 161
Cdd:cd20434   81 MSSADDYLAECFLVDYAKYIPVKSKDIRVALEAFMKLPYRAKKFRLYGIKPVTLHVDLCEDKAKIVPARKWDSAAIQYFQ 160


                 ....
gi 161016765 162 NLLK 165
Cdd:cd20434  161 NLLK 164
TUDOR pfam00567
Tudor domain;
10-128 3.34e-18

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 79.71  E-value: 3.34e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016765   10 EDPGCFWVIIKGCSPF----LDHDVDYQKLNSAMNDFYNstCQDIEIKPLTLEEGQVCVVYCEElkCWCRAIvksITSSA 85
Cdd:pfam00567   1 STIDVVVSHIESPSTFyiqpKSDSKKLEKLTEELQEYYA--SKPPESLPPAVGDGCVAAFSEDG--KWYRAK---ITESL 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 161016765   86 DQYLAECFLVDFAKNIPVKSKNIRVVVESFMQLPYRAKKFSLY 128
Cdd:pfam00567  74 DDGLVEVLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLA 116
 
Name Accession Description Interval E-value
Tudor_TDRD12_rpt1 cd20434
first Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; ...
 4-165 4.98e-97

first Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the first/N-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410505  Cd Length: 164  Bit Score: 286.24  E-value: 4.98e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016765   4 LLVLKIEDPGCFWVIIKGCSPFL-DHDVDYQKLNSAMNDFYNSTCQDIE-IKPLTLEEGQVCVVYCEELKCWCRAIVKSI 81
Cdd:cd20434    1 IQVLKIEDPGCFWGRILKGSGDLvVNPEEYENLQDEMNQFYHKGYKDVEeIKPSTLEEGQVCVVFCEELKCWCRAVVESL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016765  82 TSSADQYLAECFLVDFAKNIPVKSKNIRVVVESFMQLPYRAKKFSLYCTKPVTLHIDFCRDSTDIVPAKKWDNAAIQYFQ 161
Cdd:cd20434   81 MSSADDYLAECFLVDYAKYIPVKSKDIRVALEAFMKLPYRAKKFRLYGIKPVTLHVDLCEDKAKIVPARKWDSAAIQYFQ 160


                 ....
gi 161016765 162 NLLK 165
Cdd:cd20434  161 NLLK 164
TUDOR pfam00567
Tudor domain;
10-128 3.34e-18

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 79.71  E-value: 3.34e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016765   10 EDPGCFWVIIKGCSPF----LDHDVDYQKLNSAMNDFYNstCQDIEIKPLTLEEGQVCVVYCEElkCWCRAIvksITSSA 85
Cdd:pfam00567   1 STIDVVVSHIESPSTFyiqpKSDSKKLEKLTEELQEYYA--SKPPESLPPAVGDGCVAAFSEDG--KWYRAK---ITESL 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 161016765   86 DQYLAECFLVDFAKNIPVKSKNIRVVVESFMQLPYRAKKFSLY 128
Cdd:pfam00567  74 DDGLVEVLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLA 116
Tudor_dTUD-like cd20379
Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar ...
 59-109 1.46e-08

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410450  Cd Length: 50  Bit Score: 50.59  E-value: 1.46e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 161016765  59 EGQVCVVYCEELKCWCRAIVKSITSSadqYLAECFLVDFAKNIPVKSKNIR 109
Cdd:cd20379    1 VGDLCAAKYEEDGKWYRARVLEVLSN---DKVEVFFVDYGNTETVPLSDLR 48
Tudor_TDRD6_rpt3 cd20422
third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 9-161 5.25e-08

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410493  Cd Length: 135  Bit Score: 51.36  E-value: 5.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016765   9 IEDPGCFWVIIKgcspflDHDVDYQKLNSAMNDFYnSTCQDIEIKPLTLEEGQVCVVYCEElKCWCRAIVKSItssaDQY 88
Cdd:cd20422    9 VKDPSEFWIRLG------EHAVPFSKLMRSMTAFY-SQASKLDGVVLKPQPGQLCCAKWKE-DRYYRAIVTAV----KGK 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 161016765  89 LAECFLVDFAKNIPVKSKNIRVVVESFMQLPYRAKKFSLyctkpvtlhidfcrdsTDIVP-AKKWDNAAIQYFQ 161
Cdd:cd20422   77 MVEVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCL----------------ADICPlGERWSPEAISAFK 134
Tudor_TDRD12_rpt2 cd20435
second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; ...
 11-133 8.83e-07

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410506  Cd Length: 134  Bit Score: 47.63  E-value: 8.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016765  11 DPGCFWV-IIKGCSP----FLDHDVDYQKLNSAMNDFYNSTCQDIEIKplTLEEGQVCVVyCEELKCWCRAIVKSITSSA 85
Cdd:cd20435    1 DATHYSArILEHRSSdgevTKSMSSTYLKLSMKLNMYYSDPSNRILHG--KVKVGDLCAV-EDENNLYHRVKVLEITEKD 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 161016765  86 DQY---LAECFLVDFAKNIPVKSKNIRVVVESFMQLPYRAKKFSLYCTKPV 133
Cdd:cd20435   78 DKTkprEVLVKFIDEGRVETVVVSQLLELPEELKSLPPQAVEVFLCNVKPV 128
Tudor_TDRD1_rpt1 cd20408
first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 5-134 1.84e-06

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410479  Cd Length: 130  Bit Score: 46.98  E-value: 1.84e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016765   5 LVLKIEDPGCFWVIIKgCSPFLDHDVdyqKLNSAMNDFYNSTCQDIEIKPltlEEGQVCVVYCEELKCWCRAIVKSItsS 84
Cdd:cd20408    2 TVTEFKNPGEFYIQIY-TLEVLESLV---KLTSQLKKTYASVNNHKEYIP---EVGEVCVAKYSEDQNWYRALVQTV--D 72

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 161016765  85 ADQYLAECFLVDF--AKNIPVKSknIRVVVESFMQLPYRAKKFSLYCTKPVT 134
Cdd:cd20408   73 VQQKKAGVFYIDYgnEETVPLNR--IQPLKKDIELFPPCAIKCCLANVKPPS 122
Tudor_TDRD6_rpt4 cd20423
fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 62-128 2.50e-06

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410494  Cd Length: 80  Bit Score: 45.16  E-value: 2.50e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 161016765  62 VCVVYCEELKCWCRAIVKSITSSADQylAECFLVDFAKNIPVKSKNIRVVVESFMQLPYRAKKFSLY 128
Cdd:cd20423    8 VCLAKYSEDGKWCRALIDNVYEPVEM--VEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSLY 72
Tudor_TDRD7_rpt3 cd20429
third Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; ...
 31-122 6.75e-05

third Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410500  Cd Length: 91  Bit Score: 41.32  E-value: 6.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016765  31 DYQKLNSAMND---FYNSTcqdiEIKPLTLEEGQVCVVYCEELkcWCRAIVKSITSSAdqyLAECFLVDFAKNIPVKSKN 107
Cdd:cd20429    5 ELHKLEVLMEEmilYYNKT----EERPVAIEKNKVYAAKIENN--WYRVLVKGILTNG---LVSVYELDYGKHELVSIRK 75

                         90
                 ....*....|....*
gi 161016765 108 IRVVVESFMQLPYRA 122
Cdd:cd20429   76 VQPLIEKFRQLPFQA 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH