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Conserved domains on  [gi|162951873|ref|NP_001106175|]
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ventral anterior homeobox 1 isoform a [Homo sapiens]

Protein Classification

homeobox domain-containing protein( domain architecture ID 13432619)

homeobox domain-containing protein may be involved in the transcriptional regulation of key eukaryotic developmental processes

CATH:  1.10.10.60
Gene Ontology:  GO:0003700|GO:0003677|GO:0030154|GO:0000978|GO:0006357
PubMed:  8768896|11470884|26464018|1357790|27768937|1980756
SCOP:  4000291

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
101-157 4.33e-28

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 103.73  E-value: 4.33e-28
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 162951873  101 KRTRTSFTAEQLYRLEMEFQRCQYVVGRERTELARQLNLSETQVKVWFQNRRTKQKK 157
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
COG5576 super family cl35021
Homeodomain-containing transcription factor [Transcription];
66-184 1.62e-13

Homeodomain-containing transcription factor [Transcription];


The actual alignment was detected with superfamily member COG5576:

Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 67.08  E-value: 1.62e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162951873  66 NSAADPDYCRRILVRDAKGSIRE--------IILPKGLDLDRPKRTRTSFTAEQLYRLEMEFQRCQYVVGRERTELARQL 137
Cdd:COG5576    9 LSALESQRMPQIRTIKTTKNKREveaadsemKLERKQDGSSPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLL 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 162951873 138 NLSETQVKVWFQNRRTKQKKDQGKDSELRSVVSETAATCSVLRLLEQ 184
Cdd:COG5576   89 NMPPKSVQIWFQNKRAKEKKKRSGKVEQRPGEEEADLAKIGSLSTGQ 135
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
101-157 4.33e-28

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 103.73  E-value: 4.33e-28
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 162951873  101 KRTRTSFTAEQLYRLEMEFQRCQYVVGRERTELARQLNLSETQVKVWFQNRRTKQKK 157
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 100-156 1.42e-24

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 94.24  E-value: 1.42e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 162951873   100 PKRTRTSFTAEQLYRLEMEFQRCQYVVGRERTELARQLNLSETQVKVWFQNRRTKQK 156
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 101-159 1.31e-23

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 91.92  E-value: 1.31e-23
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 162951873 101 KRTRTSFTAEQLYRLEMEFQRCQYVVGRERTELARQLNLSETQVKVWFQNRRTKQKKDQ 159
Cdd:cd00086    1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
66-184 1.62e-13

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 67.08  E-value: 1.62e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162951873  66 NSAADPDYCRRILVRDAKGSIRE--------IILPKGLDLDRPKRTRTSFTAEQLYRLEMEFQRCQYVVGRERTELARQL 137
Cdd:COG5576    9 LSALESQRMPQIRTIKTTKNKREveaadsemKLERKQDGSSPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLL 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 162951873 138 NLSETQVKVWFQNRRTKQKKDQGKDSELRSVVSETAATCSVLRLLEQ 184
Cdd:COG5576   89 NMPPKSVQIWFQNKRAKEKKKRSGKVEQRPGEEEADLAKIGSLSTGQ 135
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
101-157 4.33e-28

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 103.73  E-value: 4.33e-28
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 162951873  101 KRTRTSFTAEQLYRLEMEFQRCQYVVGRERTELARQLNLSETQVKVWFQNRRTKQKK 157
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 100-156 1.42e-24

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 94.24  E-value: 1.42e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 162951873   100 PKRTRTSFTAEQLYRLEMEFQRCQYVVGRERTELARQLNLSETQVKVWFQNRRTKQK 156
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 101-159 1.31e-23

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 91.92  E-value: 1.31e-23
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 162951873 101 KRTRTSFTAEQLYRLEMEFQRCQYVVGRERTELARQLNLSETQVKVWFQNRRTKQKKDQ 159
Cdd:cd00086    1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
66-184 1.62e-13

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 67.08  E-value: 1.62e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162951873  66 NSAADPDYCRRILVRDAKGSIRE--------IILPKGLDLDRPKRTRTSFTAEQLYRLEMEFQRCQYVVGRERTELARQL 137
Cdd:COG5576    9 LSALESQRMPQIRTIKTTKNKREveaadsemKLERKQDGSSPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLL 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 162951873 138 NLSETQVKVWFQNRRTKQKKDQGKDSELRSVVSETAATCSVLRLLEQ 184
Cdd:COG5576   89 NMPPKSVQIWFQNKRAKEKKKRSGKVEQRPGEEEADLAKIGSLSTGQ 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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