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DEP domain-containing protein 1A isoform a [Homo sapiens]
DEP and RhoGAP_BRCC3-like domain-containing protein( domain architecture ID 10241511)
DEP and RhoGAP_BRCC3-like domain-containing protein
List of domain hits
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Name | Accession | Description | Interval | E-value | |||
DEP super family | cl02442 | DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first ... |
15-106 | 9.27e-58 | |||
DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is present. New studies show that the DEP domain of Sst2, a yeast RGS protein is necessary and sufficient for receptor interaction. The actual alignment was detected with superfamily member cd04447: Pssm-ID: 470580 Cd Length: 92 Bit Score: 191.60 E-value: 9.27e-58
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RhoGAP_BRCC3-like | cd04405 | RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ... |
181-308 | 2.39e-53 | |||
RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain and an N-terminal DEP (Disheveled, Egl-10, and Pleckstrin) domain. The function(s) of BRCC3 and DEPDC7 are unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. : Pssm-ID: 239870 Cd Length: 235 Bit Score: 184.84 E-value: 2.39e-53
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RhoGAP super family | cl02570 | RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ... |
584-690 | 1.73e-36 | |||
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins. The actual alignment was detected with superfamily member cd04405: Pssm-ID: 470621 Cd Length: 235 Bit Score: 137.46 E-value: 1.73e-36
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RhoGAP super family | cl45980 | RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. |
281-356 | 1.76e-03 | |||
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. The actual alignment was detected with superfamily member pfam00620: Pssm-ID: 459875 Cd Length: 148 Bit Score: 39.45 E-value: 1.76e-03
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Name | Accession | Description | Interval | E-value | |||
DEP_BRCC3 | cd04447 | DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in BBRC3-like proteins. BBRC3, also ... |
15-106 | 9.27e-58 | |||
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in BBRC3-like proteins. BBRC3, also known as DEPDC1B, is a DEP containing protein of unknown function. Pssm-ID: 239894 Cd Length: 92 Bit Score: 191.60 E-value: 9.27e-58
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RhoGAP_BRCC3-like | cd04405 | RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ... |
181-308 | 2.39e-53 | |||
RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain and an N-terminal DEP (Disheveled, Egl-10, and Pleckstrin) domain. The function(s) of BRCC3 and DEPDC7 are unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. Pssm-ID: 239870 Cd Length: 235 Bit Score: 184.84 E-value: 2.39e-53
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RhoGAP_BRCC3-like | cd04405 | RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ... |
584-690 | 1.73e-36 | |||
RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain and an N-terminal DEP (Disheveled, Egl-10, and Pleckstrin) domain. The function(s) of BRCC3 and DEPDC7 are unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. Pssm-ID: 239870 Cd Length: 235 Bit Score: 137.46 E-value: 1.73e-36
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DEP | pfam00610 | Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP); The DEP domain is responsible for ... |
27-106 | 3.54e-16 | |||
Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP); The DEP domain is responsible for mediating intracellular protein targeting and regulation of protein stability in the cell. The DEP domain is present in a number of signaling molecules, including Regulator of G protein Signaling (RGS) proteins, and has been implicated in membrane targeting. New findings in yeast, however, demonstrate a major role for a DEP domain in mediating the interaction of an RGS protein to the C-terminal tail of a GPCR, thus placing RGS in close proximity with its substrate G protein alpha subunit. Pssm-ID: 459867 Cd Length: 71 Bit Score: 73.78 E-value: 3.54e-16
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DEP | smart00049 | Domain found in Dishevelled, Egl-10, and Pleckstrin; Domain of unknown function present in ... |
24-107 | 3.98e-16 | |||
Domain found in Dishevelled, Egl-10, and Pleckstrin; Domain of unknown function present in signalling proteins that contain PH, rasGEF, rhoGEF, rhoGAP, RGS, PDZ domains. DEP domain in Drosophila dishevelled is essential to rescue planar polarity defects and induce JNK signalling (Cell 94, 109-118). Pssm-ID: 214489 Cd Length: 77 Bit Score: 73.86 E-value: 3.98e-16
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RhoGAP | pfam00620 | RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. |
281-356 | 1.76e-03 | |||
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. Pssm-ID: 459875 Cd Length: 148 Bit Score: 39.45 E-value: 1.76e-03
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RhoGAP | smart00324 | GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ... |
278-341 | 8.89e-03 | |||
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers. Pssm-ID: 214618 Cd Length: 174 Bit Score: 38.02 E-value: 8.89e-03
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Name | Accession | Description | Interval | E-value | |||
DEP_BRCC3 | cd04447 | DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in BBRC3-like proteins. BBRC3, also ... |
15-106 | 9.27e-58 | |||
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in BBRC3-like proteins. BBRC3, also known as DEPDC1B, is a DEP containing protein of unknown function. Pssm-ID: 239894 Cd Length: 92 Bit Score: 191.60 E-value: 9.27e-58
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RhoGAP_BRCC3-like | cd04405 | RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ... |
181-308 | 2.39e-53 | |||
RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain and an N-terminal DEP (Disheveled, Egl-10, and Pleckstrin) domain. The function(s) of BRCC3 and DEPDC7 are unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. Pssm-ID: 239870 Cd Length: 235 Bit Score: 184.84 E-value: 2.39e-53
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RhoGAP_BRCC3-like | cd04405 | RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ... |
584-690 | 1.73e-36 | |||
RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain and an N-terminal DEP (Disheveled, Egl-10, and Pleckstrin) domain. The function(s) of BRCC3 and DEPDC7 are unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. Pssm-ID: 239870 Cd Length: 235 Bit Score: 137.46 E-value: 1.73e-36
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DEP | pfam00610 | Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP); The DEP domain is responsible for ... |
27-106 | 3.54e-16 | |||
Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP); The DEP domain is responsible for mediating intracellular protein targeting and regulation of protein stability in the cell. The DEP domain is present in a number of signaling molecules, including Regulator of G protein Signaling (RGS) proteins, and has been implicated in membrane targeting. New findings in yeast, however, demonstrate a major role for a DEP domain in mediating the interaction of an RGS protein to the C-terminal tail of a GPCR, thus placing RGS in close proximity with its substrate G protein alpha subunit. Pssm-ID: 459867 Cd Length: 71 Bit Score: 73.78 E-value: 3.54e-16
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DEP | smart00049 | Domain found in Dishevelled, Egl-10, and Pleckstrin; Domain of unknown function present in ... |
24-107 | 3.98e-16 | |||
Domain found in Dishevelled, Egl-10, and Pleckstrin; Domain of unknown function present in signalling proteins that contain PH, rasGEF, rhoGEF, rhoGAP, RGS, PDZ domains. DEP domain in Drosophila dishevelled is essential to rescue planar polarity defects and induce JNK signalling (Cell 94, 109-118). Pssm-ID: 214489 Cd Length: 77 Bit Score: 73.86 E-value: 3.98e-16
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DEP | cd04371 | DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first ... |
24-105 | 4.22e-13 | |||
DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is present. New studies show that the DEP domain of Sst2, a yeast RGS protein is necessary and sufficient for receptor interaction. Pssm-ID: 239836 Cd Length: 81 Bit Score: 65.05 E-value: 4.22e-13
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DEP_DEPDC4 | cd04446 | DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC4-like proteins. DEPDC4 is a ... |
17-105 | 1.18e-08 | |||
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC4-like proteins. DEPDC4 is a DEP domain containing protein of unknown function. Pssm-ID: 239893 Cd Length: 95 Bit Score: 53.14 E-value: 1.18e-08
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DEP_PIKfyve | cd04448 | DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange ... |
16-53 | 2.84e-05 | |||
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol phosphate kinase) domain. PIKfyve-like proteins are important phosphatidylinositol (3)-monophosphate (PtdIns(3)P)-5-kinases, producing PtdIns(3,5)P2, which plays a major role in multivesicular body (MVB) sorting and control of retrograde traffic from the vacuole back to the endosome and/or Golgi. PIKfyve itself has been shown to be play a role in regulating early-endosome-to-trans-Golgi network (TGN) retrograde trafficking. Pssm-ID: 239895 Cd Length: 81 Bit Score: 43.20 E-value: 2.84e-05
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DEP_DEPDC5-like | cd04449 | DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in ... |
34-91 | 6.57e-04 | |||
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function. Pssm-ID: 239896 Cd Length: 83 Bit Score: 39.18 E-value: 6.57e-04
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RhoGAP | pfam00620 | RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. |
281-356 | 1.76e-03 | |||
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. Pssm-ID: 459875 Cd Length: 148 Bit Score: 39.45 E-value: 1.76e-03
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DEP_1_DEP6 | cd04442 | DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in DEP6-like proteins. DEP6 proteins ... |
30-88 | 5.33e-03 | |||
DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in DEP6-like proteins. DEP6 proteins contain two DEP and a PDZ domain. Their function is unknown. Pssm-ID: 239889 [Multi-domain] Cd Length: 82 Bit Score: 36.80 E-value: 5.33e-03
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RhoGAP | smart00324 | GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ... |
278-341 | 8.89e-03 | |||
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers. Pssm-ID: 214618 Cd Length: 174 Bit Score: 38.02 E-value: 8.89e-03
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Blast search parameters | ||||
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