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Conserved domains on  [gi|166295188|ref|NP_001107592|]
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DEP domain-containing protein 1A isoform a [Homo sapiens]

Protein Classification

DEP and RhoGAP_BRCC3-like domain-containing protein( domain architecture ID 10241511)

DEP and RhoGAP_BRCC3-like domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DEP super family cl02442
DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first ...
 15-106 9.27e-58

DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is present. New studies show that the DEP domain of Sst2, a yeast RGS protein is necessary and sufficient for receptor interaction.


The actual alignment was detected with superfamily member cd04447:

Pssm-ID: 470580  Cd Length: 92  Bit Score: 191.60  E-value: 9.27e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166295188  15 KLWNEVTTSFRAGMPLRKHRQHFKKYGNCFTAGEAVDWLYDLLRNNSNFGPEVTRQQTIQLLRKFLKNHVIEDIKGRWGS 94
Cdd:cd04447    1 KLWNEVTELFRAGMPLRKHRQHFKSYENCFTASEAVDWLHELLRSNSNFGPEVTRQQTVQLLKKFLKNHVIEDIKGRWGK 80

                         90
                 ....*....|..
gi 166295188  95 ENVDDNNQLFRF 106
Cdd:cd04447   81 EDLEDNNHLYRF 92
RhoGAP_BRCC3-like cd04405
RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 181-308 2.39e-53

RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain and an N-terminal DEP (Disheveled, Egl-10, and Pleckstrin) domain. The function(s) of BRCC3 and DEPDC7 are unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


:

Pssm-ID: 239870  Cd Length: 235  Bit Score: 184.84  E-value: 2.39e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166295188 181 LSQEDVEEVWRYVILIYLQTILGVPSLEEVINPKQVIPQYIMYNM------ANTSKRGVVILQNKSdDLPHWVLSAMKCL 254
Cdd:cd04405    1 LSPEVVEEIWKEQTLIRLLQLVGLPLLEELLDPALVNPKHISYNMdpdvytSNYLDREVVKLFSKS-QLDHWLLSAMDCL 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 166295188 255 ANWPRS--NDMNNPTYV------GFERDVFRTIADYFLDLPEPLLTFEYYELFVNILVVCGY 308
Cdd:cd04405   80 ANWPDQlvVDVSRPLYSqhdmlsGFKRLLFKTIAKYYGQLKEPLLTFHLFDIFVGILELLGN 141
RhoGAP super family cl02570
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 584-690 1.73e-36

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


The actual alignment was detected with superfamily member cd04405:

Pssm-ID: 470621  Cd Length: 235  Bit Score: 137.46  E-value: 1.73e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166295188 584 TGTQSLLQPHLERVAIDALQLCCLLLPPPNRRKLQLLMRMISRMSQNvDMPKLHDAMGTRSLMIHTFSRCVLCCAeevDL 663
Cdd:cd04405  133 VGILELLGNGKEEVALEALQLCLLLLPPASRRELRRLLRFMARAAKN-DMPRLHKEIENRMLVKQTFSRAILCSK---DL 208

                         90       100
                 ....*....|....*....|....*..
gi 166295188 664 DELLAGRLVSFLMDHHQEILQVPSYLQ 690
Cdd:cd04405  209 DEGLADLLVLFLMDHHQDIFKVPGSLH 235
RhoGAP super family cl45980
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 281-356 1.76e-03

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


The actual alignment was detected with superfamily member pfam00620:

Pssm-ID: 459875  Cd Length: 148  Bit Score: 39.45  E-value: 1.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166295188  281 DYFLDLPEPLLTFEYYELFVNILvvcgyiTVSDRSSGIHKIQDDPQSskfLHLNNLNSFKSteclLLSLLHR-----EKN 355
Cdd:pfam00620  62 LFLRELPEPLLTFELYEEFIEAA------KLPDEEERLEALRELLRK---LPPANRDTLRY----LLAHLNRvaqnsDVN 128


                  .
gi 166295188  356 K 356
Cdd:pfam00620 129 K 129
 
Name Accession Description Interval E-value
DEP_BRCC3 cd04447
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in BBRC3-like proteins. BBRC3, also ...
 15-106 9.27e-58

DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in BBRC3-like proteins. BBRC3, also known as DEPDC1B, is a DEP containing protein of unknown function.


Pssm-ID: 239894  Cd Length: 92  Bit Score: 191.60  E-value: 9.27e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166295188  15 KLWNEVTTSFRAGMPLRKHRQHFKKYGNCFTAGEAVDWLYDLLRNNSNFGPEVTRQQTIQLLRKFLKNHVIEDIKGRWGS 94
Cdd:cd04447    1 KLWNEVTELFRAGMPLRKHRQHFKSYENCFTASEAVDWLHELLRSNSNFGPEVTRQQTVQLLKKFLKNHVIEDIKGRWGK 80

                         90
                 ....*....|..
gi 166295188  95 ENVDDNNQLFRF 106
Cdd:cd04447   81 EDLEDNNHLYRF 92
RhoGAP_BRCC3-like cd04405
RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 181-308 2.39e-53

RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain and an N-terminal DEP (Disheveled, Egl-10, and Pleckstrin) domain. The function(s) of BRCC3 and DEPDC7 are unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239870  Cd Length: 235  Bit Score: 184.84  E-value: 2.39e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166295188 181 LSQEDVEEVWRYVILIYLQTILGVPSLEEVINPKQVIPQYIMYNM------ANTSKRGVVILQNKSdDLPHWVLSAMKCL 254
Cdd:cd04405    1 LSPEVVEEIWKEQTLIRLLQLVGLPLLEELLDPALVNPKHISYNMdpdvytSNYLDREVVKLFSKS-QLDHWLLSAMDCL 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 166295188 255 ANWPRS--NDMNNPTYV------GFERDVFRTIADYFLDLPEPLLTFEYYELFVNILVVCGY 308
Cdd:cd04405   80 ANWPDQlvVDVSRPLYSqhdmlsGFKRLLFKTIAKYYGQLKEPLLTFHLFDIFVGILELLGN 141
RhoGAP_BRCC3-like cd04405
RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 584-690 1.73e-36

RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain and an N-terminal DEP (Disheveled, Egl-10, and Pleckstrin) domain. The function(s) of BRCC3 and DEPDC7 are unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239870  Cd Length: 235  Bit Score: 137.46  E-value: 1.73e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166295188 584 TGTQSLLQPHLERVAIDALQLCCLLLPPPNRRKLQLLMRMISRMSQNvDMPKLHDAMGTRSLMIHTFSRCVLCCAeevDL 663
Cdd:cd04405  133 VGILELLGNGKEEVALEALQLCLLLLPPASRRELRRLLRFMARAAKN-DMPRLHKEIENRMLVKQTFSRAILCSK---DL 208

                         90       100
                 ....*....|....*....|....*..
gi 166295188 664 DELLAGRLVSFLMDHHQEILQVPSYLQ 690
Cdd:cd04405  209 DEGLADLLVLFLMDHHQDIFKVPGSLH 235
DEP pfam00610
Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP); The DEP domain is responsible for ...
 27-106 3.54e-16

Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP); The DEP domain is responsible for mediating intracellular protein targeting and regulation of protein stability in the cell. The DEP domain is present in a number of signaling molecules, including Regulator of G protein Signaling (RGS) proteins, and has been implicated in membrane targeting. New findings in yeast, however, demonstrate a major role for a DEP domain in mediating the interaction of an RGS protein to the C-terminal tail of a GPCR, thus placing RGS in close proximity with its substrate G protein alpha subunit.


Pssm-ID: 459867  Cd Length: 71  Bit Score: 73.78  E-value: 3.54e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166295188   27 GMPLRKHRQHFKKYGNCFTAGEAVDWLYDLlrnnsnfGPEVTRQQTIQLLRKFLKNHVIEDIKGRWGseNVDDNNQLFRF 106
Cdd:pfam00610   1 GVKLKDRRKHLKTYPNCFTGSEAVDWLMDN-------LEIITREEAVELGQLLLDQGLIHHVGDKHG--LFKDSYYFYRF 71
DEP smart00049
Domain found in Dishevelled, Egl-10, and Pleckstrin; Domain of unknown function present in ...
 24-107 3.98e-16

Domain found in Dishevelled, Egl-10, and Pleckstrin; Domain of unknown function present in signalling proteins that contain PH, rasGEF, rhoGEF, rhoGAP, RGS, PDZ domains. DEP domain in Drosophila dishevelled is essential to rescue planar polarity defects and induce JNK signalling (Cell 94, 109-118).


Pssm-ID: 214489  Cd Length: 77  Bit Score: 73.86  E-value: 3.98e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166295188    24 FRAGMPLRKHRQHFKKYGNCFTAGEAVDWLYDLLrnnsnfgPEVTRQQTIQLLRKFLKNHVIEDIKGrWGSENVDDNNQL 103
Cdd:smart00049   1 PETGLKLRDRKYFLKTYPNCFTGSELVDWLMDNL-------EIIDREEAVHLGQLLLDEGLIHHVNG-PNKHTFKDSKAL 72


                   ....
gi 166295188   104 FRFP 107
Cdd:smart00049  73 YRFT 76
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 281-356 1.76e-03

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 39.45  E-value: 1.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166295188  281 DYFLDLPEPLLTFEYYELFVNILvvcgyiTVSDRSSGIHKIQDDPQSskfLHLNNLNSFKSteclLLSLLHR-----EKN 355
Cdd:pfam00620  62 LFLRELPEPLLTFELYEEFIEAA------KLPDEEERLEALRELLRK---LPPANRDTLRY----LLAHLNRvaqnsDVN 128


                  .
gi 166295188  356 K 356
Cdd:pfam00620 129 K 129
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 278-341 8.89e-03

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 38.02  E-value: 8.89e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 166295188   278 TIAD----YFLDLPEPLLTFEYYELFvniLVVCGYITVSDRSSGIHK-IQDDPQSSK------FLHLNNLNSFKS 341
Cdd:smart00324  58 DVAGllklFLRELPEPLITYELYEEF---IEAAKLEDETERLRALRElLSLLPPANRatlrylLAHLNRVAEHSE 129
 
Name Accession Description Interval E-value
DEP_BRCC3 cd04447
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in BBRC3-like proteins. BBRC3, also ...
 15-106 9.27e-58

DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in BBRC3-like proteins. BBRC3, also known as DEPDC1B, is a DEP containing protein of unknown function.


Pssm-ID: 239894  Cd Length: 92  Bit Score: 191.60  E-value: 9.27e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166295188  15 KLWNEVTTSFRAGMPLRKHRQHFKKYGNCFTAGEAVDWLYDLLRNNSNFGPEVTRQQTIQLLRKFLKNHVIEDIKGRWGS 94
Cdd:cd04447    1 KLWNEVTELFRAGMPLRKHRQHFKSYENCFTASEAVDWLHELLRSNSNFGPEVTRQQTVQLLKKFLKNHVIEDIKGRWGK 80

                         90
                 ....*....|..
gi 166295188  95 ENVDDNNQLFRF 106
Cdd:cd04447   81 EDLEDNNHLYRF 92
RhoGAP_BRCC3-like cd04405
RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 181-308 2.39e-53

RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain and an N-terminal DEP (Disheveled, Egl-10, and Pleckstrin) domain. The function(s) of BRCC3 and DEPDC7 are unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239870  Cd Length: 235  Bit Score: 184.84  E-value: 2.39e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166295188 181 LSQEDVEEVWRYVILIYLQTILGVPSLEEVINPKQVIPQYIMYNM------ANTSKRGVVILQNKSdDLPHWVLSAMKCL 254
Cdd:cd04405    1 LSPEVVEEIWKEQTLIRLLQLVGLPLLEELLDPALVNPKHISYNMdpdvytSNYLDREVVKLFSKS-QLDHWLLSAMDCL 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 166295188 255 ANWPRS--NDMNNPTYV------GFERDVFRTIADYFLDLPEPLLTFEYYELFVNILVVCGY 308
Cdd:cd04405   80 ANWPDQlvVDVSRPLYSqhdmlsGFKRLLFKTIAKYYGQLKEPLLTFHLFDIFVGILELLGN 141
RhoGAP_BRCC3-like cd04405
RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 584-690 1.73e-36

RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain and an N-terminal DEP (Disheveled, Egl-10, and Pleckstrin) domain. The function(s) of BRCC3 and DEPDC7 are unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239870  Cd Length: 235  Bit Score: 137.46  E-value: 1.73e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166295188 584 TGTQSLLQPHLERVAIDALQLCCLLLPPPNRRKLQLLMRMISRMSQNvDMPKLHDAMGTRSLMIHTFSRCVLCCAeevDL 663
Cdd:cd04405  133 VGILELLGNGKEEVALEALQLCLLLLPPASRRELRRLLRFMARAAKN-DMPRLHKEIENRMLVKQTFSRAILCSK---DL 208

                         90       100
                 ....*....|....*....|....*..
gi 166295188 664 DELLAGRLVSFLMDHHQEILQVPSYLQ 690
Cdd:cd04405  209 DEGLADLLVLFLMDHHQDIFKVPGSLH 235
DEP pfam00610
Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP); The DEP domain is responsible for ...
 27-106 3.54e-16

Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP); The DEP domain is responsible for mediating intracellular protein targeting and regulation of protein stability in the cell. The DEP domain is present in a number of signaling molecules, including Regulator of G protein Signaling (RGS) proteins, and has been implicated in membrane targeting. New findings in yeast, however, demonstrate a major role for a DEP domain in mediating the interaction of an RGS protein to the C-terminal tail of a GPCR, thus placing RGS in close proximity with its substrate G protein alpha subunit.


Pssm-ID: 459867  Cd Length: 71  Bit Score: 73.78  E-value: 3.54e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166295188   27 GMPLRKHRQHFKKYGNCFTAGEAVDWLYDLlrnnsnfGPEVTRQQTIQLLRKFLKNHVIEDIKGRWGseNVDDNNQLFRF 106
Cdd:pfam00610   1 GVKLKDRRKHLKTYPNCFTGSEAVDWLMDN-------LEIITREEAVELGQLLLDQGLIHHVGDKHG--LFKDSYYFYRF 71
DEP smart00049
Domain found in Dishevelled, Egl-10, and Pleckstrin; Domain of unknown function present in ...
 24-107 3.98e-16

Domain found in Dishevelled, Egl-10, and Pleckstrin; Domain of unknown function present in signalling proteins that contain PH, rasGEF, rhoGEF, rhoGAP, RGS, PDZ domains. DEP domain in Drosophila dishevelled is essential to rescue planar polarity defects and induce JNK signalling (Cell 94, 109-118).


Pssm-ID: 214489  Cd Length: 77  Bit Score: 73.86  E-value: 3.98e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166295188    24 FRAGMPLRKHRQHFKKYGNCFTAGEAVDWLYDLLrnnsnfgPEVTRQQTIQLLRKFLKNHVIEDIKGrWGSENVDDNNQL 103
Cdd:smart00049   1 PETGLKLRDRKYFLKTYPNCFTGSELVDWLMDNL-------EIIDREEAVHLGQLLLDEGLIHHVNG-PNKHTFKDSKAL 72


                   ....
gi 166295188   104 FRFP 107
Cdd:smart00049  73 YRFT 76
DEP cd04371
DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first ...
 24-105 4.22e-13

DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is present. New studies show that the DEP domain of Sst2, a yeast RGS protein is necessary and sufficient for receptor interaction.


Pssm-ID: 239836  Cd Length: 81  Bit Score: 65.05  E-value: 4.22e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166295188  24 FRAGMPLRKHRQHFKKYGNCFTAGEAVDWLYDllrnnsnFGPEVTRQQTIQLLRKFLKNHVIEDIKGrwGSENVDDNNQL 103
Cdd:cd04371    9 SDSGVPIKDRKYHLKTYPNCFTGSELVDWLLD-------NLEAITREEAVELGQALLKHGLIHHVSD--DKHTFRDSYAL 79


                 ..
gi 166295188 104 FR 105
Cdd:cd04371   80 YR 81
DEP_DEPDC4 cd04446
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC4-like proteins. DEPDC4 is a ...
 17-105 1.18e-08

DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC4-like proteins. DEPDC4 is a DEP domain containing protein of unknown function.


Pssm-ID: 239893  Cd Length: 95  Bit Score: 53.14  E-value: 1.18e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166295188  17 WNEVTTSFRAGMPLRKHRQHFKKYGNCFTAGEAVDWLYD-LLRNNSNFGPEVTRQQTIQLLRKFLKNHVIEDIKGRWGSE 95
Cdd:cd04446    1 WNSIIDALQTQVEVKKRRHNLKSYHDCFLGSEAVDVVLAhLMQNKYFGDVDVPRAKAVRLCQALMDCRVFEAVGTKVFKK 80

                         90
                 ....*....|....*
gi 166295188  96 NV-----DDNNQLFR 105
Cdd:cd04446   81 KKravfeDSSSSLYR 95
DEP_PIKfyve cd04448
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange ...
 16-53 2.84e-05

DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol phosphate kinase) domain. PIKfyve-like proteins are important phosphatidylinositol (3)-monophosphate (PtdIns(3)P)-5-kinases, producing PtdIns(3,5)P2, which plays a major role in multivesicular body (MVB) sorting and control of retrograde traffic from the vacuole back to the endosome and/or Golgi. PIKfyve itself has been shown to be play a role in regulating early-endosome-to-trans-Golgi network (TGN) retrograde trafficking.


Pssm-ID: 239895  Cd Length: 81  Bit Score: 43.20  E-value: 2.84e-05
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 166295188  16 LWNEVTTSfRAGMPLRKHRQHFKKYGNCFTAGEAVDWL 53
Cdd:cd04448    2 LWEKICRS-STGIEFQDHRYRLRTYTNCILGKELVNWL 38
DEP_DEPDC5-like cd04449
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in ...
 34-91 6.57e-04

DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.


Pssm-ID: 239896  Cd Length: 83  Bit Score: 39.18  E-value: 6.57e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 166295188  34 RQHFKKYGNCFTAGEAVDWLYDllrnnsNFGPEVTRQQTIQLLRKFLKNHVIEDIKGR 91
Cdd:cd04449   20 SWHKGLPSNCFIGSEAVSWLIN------NFEDVDTREEAVELGQELMNEGLIEHVSGR 71
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 281-356 1.76e-03

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 39.45  E-value: 1.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166295188  281 DYFLDLPEPLLTFEYYELFVNILvvcgyiTVSDRSSGIHKIQDDPQSskfLHLNNLNSFKSteclLLSLLHR-----EKN 355
Cdd:pfam00620  62 LFLRELPEPLLTFELYEEFIEAA------KLPDEEERLEALRELLRK---LPPANRDTLRY----LLAHLNRvaqnsDVN 128


                  .
gi 166295188  356 K 356
Cdd:pfam00620 129 K 129
DEP_1_DEP6 cd04442
DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in DEP6-like proteins. DEP6 proteins ...
 30-88 5.33e-03

DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in DEP6-like proteins. DEP6 proteins contain two DEP and a PDZ domain. Their function is unknown.


Pssm-ID: 239889 [Multi-domain]  Cd Length: 82  Bit Score: 36.80  E-value: 5.33e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 166295188  30 LRKHRQHFKKYGNCFTAGEAVDWLYDllrnnsnfGPEVT-RQQTIQLLRKFLKNHVIEDI 88
Cdd:cd04442   15 IKDRRHHLRTYPNCFVGKELIDWLIE--------HKEASdRETAIKIMQKLLDHSIIHHV 66
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 278-341 8.89e-03

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 38.02  E-value: 8.89e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 166295188   278 TIAD----YFLDLPEPLLTFEYYELFvniLVVCGYITVSDRSSGIHK-IQDDPQSSK------FLHLNNLNSFKS 341
Cdd:smart00324  58 DVAGllklFLRELPEPLITYELYEEF---IEAAKLEDETERLRALRElLSLLPPANRatlrylLAHLNRVAEHSE 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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