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Conserved domains on  [gi|187960035|ref|NP_001107653|]
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rRNA N6-adenosine-methyltransferase METTL5 [Rattus norvegicus]

Protein Classification

METTL5 family protein( domain architecture ID 10006292)

METTL5 family protein similar to Homo sapiens methyltransferase-like protein 5 that is a catalytic subunit of a heterodimer with TRMT112, which specifically methylates the 6th position of adenine in position 1832 of 18S rRNA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
7-208 8.82e-70

Predicted RNA methylase [General function prediction only];


:

Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 211.30  E-value: 8.82e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187960035   7 KELESRLQEVDGFEKPKLLLEQYPTRPHIAACMLYTIHnTYDDIESKAVADLGCGCGVLSIGAAMLGAGLCVGFDIDEDA 86
Cdd:COG2263    2 RELEIILEKLPGFSNPKVELEQYPTPAELAAELLHLAY-LRGDIEGKTVLDLGCGTGMLAIGAALLGAKKVVGVDIDPEA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187960035  87 LEIFNKNVEEFElTNVDMIQCDVYSLSSrmSKLFDTVIMNPPFGTkNNKGTDMAFLKTALGMARtAVYSLHKSSTREHIQ 166
Cdd:COG2263   81 LEIARENAERLG-VRVDFIRADVTRIPL--GGSVDTVVMNPPFGA-QRRHADRPFLEKALEIAA-VIYSIHNAGSLDFVE 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 187960035 167 KKAAEWKVKTEIIAELRYDLPALYNFHKKKSVDIEVDLIRFS 208
Cdd:COG2263  156 RFAADRGGEITHVFRAEFPIPRTFEFHRKRRRRIEVEVYRIE 197
 
Name Accession Description Interval E-value
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
7-208 8.82e-70

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 211.30  E-value: 8.82e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187960035   7 KELESRLQEVDGFEKPKLLLEQYPTRPHIAACMLYTIHnTYDDIESKAVADLGCGCGVLSIGAAMLGAGLCVGFDIDEDA 86
Cdd:COG2263    2 RELEIILEKLPGFSNPKVELEQYPTPAELAAELLHLAY-LRGDIEGKTVLDLGCGTGMLAIGAALLGAKKVVGVDIDPEA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187960035  87 LEIFNKNVEEFElTNVDMIQCDVYSLSSrmSKLFDTVIMNPPFGTkNNKGTDMAFLKTALGMARtAVYSLHKSSTREHIQ 166
Cdd:COG2263   81 LEIARENAERLG-VRVDFIRADVTRIPL--GGSVDTVVMNPPFGA-QRRHADRPFLEKALEIAA-VIYSIHNAGSLDFVE 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 187960035 167 KKAAEWKVKTEIIAELRYDLPALYNFHKKKSVDIEVDLIRFS 208
Cdd:COG2263  156 RFAADRGGEITHVFRAEFPIPRTFEFHRKRRRRIEVEVYRIE 197
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 46-145 7.54e-13

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 63.76  E-value: 7.54e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187960035   46 TYDDIESKAVADLGCGCGVLSIGAAMLGAGLCV-GFDIDEDALEIFNKNVEEFELTNVDMIQCDVYslSSRMSKLFDTVI 124
Cdd:pfam05175  26 HLPKDLSGKVLDLGCGAGVLGAALAKESPDAELtMVDINARALESARENLAANGLENGEVVASDVY--SGVEDGKFDLII 103

                          90       100
                  ....*....|....*....|...
gi 187960035  125 MNPPF--GTKNNKGTDMAFLKTA 145
Cdd:pfam05175 104 SNPPFhaGLATTYNVAQRFIADA 126
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
49-95 1.31e-11

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 61.71  E-value: 1.31e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 187960035  49 DIESKAVADLGCGCGVLSIGAAMLGAGLCVGFDIDEDALEIFNKNVE 95
Cdd:PRK00517 117 VLPGKTVLDVGCGSGILAIAAAKLGAKKVLAVDIDPQAVEAARENAE 163
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 55-129 8.73e-11

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 56.67  E-value: 8.73e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 187960035  55 VADLGCGCGVLSIGAAMLGAGLCVGFDIDEDALEIFNKNVEEFELTNVDMIQCDVYSLSSRMSKLFDTVIMNPPF 129
Cdd:cd02440    2 VLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPPEADESFDVIISDPPL 76
 
Name Accession Description Interval E-value
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
7-208 8.82e-70

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 211.30  E-value: 8.82e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187960035   7 KELESRLQEVDGFEKPKLLLEQYPTRPHIAACMLYTIHnTYDDIESKAVADLGCGCGVLSIGAAMLGAGLCVGFDIDEDA 86
Cdd:COG2263    2 RELEIILEKLPGFSNPKVELEQYPTPAELAAELLHLAY-LRGDIEGKTVLDLGCGTGMLAIGAALLGAKKVVGVDIDPEA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187960035  87 LEIFNKNVEEFElTNVDMIQCDVYSLSSrmSKLFDTVIMNPPFGTkNNKGTDMAFLKTALGMARtAVYSLHKSSTREHIQ 166
Cdd:COG2263   81 LEIARENAERLG-VRVDFIRADVTRIPL--GGSVDTVVMNPPFGA-QRRHADRPFLEKALEIAA-VIYSIHNAGSLDFVE 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 187960035 167 KKAAEWKVKTEIIAELRYDLPALYNFHKKKSVDIEVDLIRFS 208
Cdd:COG2263  156 RFAADRGGEITHVFRAEFPIPRTFEFHRKRRRRIEVEVYRIE 197
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 48-146 9.94e-18

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 77.15  E-value: 9.94e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187960035  48 DDIESKAVADLGCGCGVLSIGAAMLGAGLCV-GFDIDEDALEIFNKNVEEFELTNVDMIQCDVYslSSRMSKLFDTVIMN 126
Cdd:COG2813   46 PEPLGGRVLDLGCGYGVIGLALAKRNPEARVtLVDVNARAVELARANAAANGLENVEVLWSDGL--SGVPDGSFDLILSN 123

                         90       100
                 ....*....|....*....|..
gi 187960035 127 PPF--GTKNNKGTDMAFLKTAL 146
Cdd:COG2813  124 PPFhaGRAVDKEVAHALIADAA 145
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 46-145 7.54e-13

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 63.76  E-value: 7.54e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187960035   46 TYDDIESKAVADLGCGCGVLSIGAAMLGAGLCV-GFDIDEDALEIFNKNVEEFELTNVDMIQCDVYslSSRMSKLFDTVI 124
Cdd:pfam05175  26 HLPKDLSGKVLDLGCGAGVLGAALAKESPDAELtMVDINARALESARENLAANGLENGEVVASDVY--SGVEDGKFDLII 103

                          90       100
                  ....*....|....*....|...
gi 187960035  125 MNPPF--GTKNNKGTDMAFLKTA 145
Cdd:pfam05175 104 SNPPFhaGLATTYNVAQRFIADA 126
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
53-95 4.95e-12

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 63.27  E-value: 4.95e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 187960035  53 KAVADLGCGCGVLSIGAAMLGAGLCVGFDIDEDALEIFNKNVE 95
Cdd:COG2264  150 KTVLDVGCGSGILAIAAAKLGAKRVLAVDIDPVAVEAARENAE 192
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
49-95 1.31e-11

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 61.71  E-value: 1.31e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 187960035  49 DIESKAVADLGCGCGVLSIGAAMLGAGLCVGFDIDEDALEIFNKNVE 95
Cdd:PRK00517 117 VLPGKTVLDVGCGSGILAIAAAKLGAKKVLAVDIDPQAVEAARENAE 163
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 55-129 1.86e-11

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 61.31  E-value: 1.86e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 187960035  55 VADLGCGCGVLSIG-AAMLGAGLCVGFDIDEDALEIFNKNVEEFELTN-VDMIQCDVYSLSSRM-SKLFDTVIMNPPF 129
Cdd:COG4123   41 VLDLGTGTGVIALMlAQRSPGARITGVEIQPEAAELARRNVALNGLEDrITVIHGDLKEFAAELpPGSFDLVVSNPPY 118
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 55-129 8.73e-11

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 56.67  E-value: 8.73e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 187960035  55 VADLGCGCGVLSIGAAMLGAGLCVGFDIDEDALEIFNKNVEEFELTNVDMIQCDVYSLSSRMSKLFDTVIMNPPF 129
Cdd:cd02440    2 VLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPPEADESFDVIISDPPL 76
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 55-126 2.81e-10

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 54.88  E-value: 2.81e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 187960035   55 VADLGCGCGVLSIGAAMLGAGLCVGFDIDEDALEIFNKNVEEFELtNVDMIQCDVYSLSSRMSKlFDTVIMN 126
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEMLERARERAAEAGL-NVEFVQGDAEDLPFPDGS-FDLVVSS 70
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 53-126 5.45e-10

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 57.66  E-value: 5.45e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 187960035   53 KAVADLGCGCGVLSIGAAMLGAGLCVGFDIDEDALEIFNKNveeFELTNVDMiQCDVYSLSSRMSKLFDTVIMN 126
Cdd:pfam06325 163 ESVLDVGCGSGILAIAALKLGAKKVVGVDIDPVAVRAAKEN---AELNGVEA-RLEVYLPGDLPKEKADVVVAN 232
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 51-128 4.14e-09

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 54.78  E-value: 4.14e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 187960035  51 ESKAVADLGCGCGVLSIGAAMLGAGLCV-GFDIDEDALEIFNKNVEEFELTNVDMIQCDVysLSSRMSKLFDTVIMNPP 128
Cdd:PRK09328 108 EPLRVLDLGTGSGAIALALAKERPDAEVtAVDISPEALAVARRNAKHGLGARVEFLQGDW--FEPLPGGRFDLIVSNPP 184
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 51-126 5.46e-09

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 52.33  E-value: 5.46e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 187960035  51 ESKAVADLGCGCGVLSIGAAMLGAgLCVGFDIDEDALEIFNKNVEEFeltNVDMIQCDVYSLSSRMSKlFDTVIMN 126
Cdd:COG2227   24 AGGRVLDVGCGTGRLALALARRGA-DVTGVDISPEALEIARERAAEL---NVDFVQGDLEDLPLEDGS-FDLVICS 94
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 48-128 8.47e-09

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 54.00  E-value: 8.47e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187960035  48 DDIESKAVADLGCGCGVLSIG-AAMLGAGLCVGFDIDEDALEIFNKNVEEFELTN-VDMIQCDVYS-LSSRMSklFDTVI 124
Cdd:COG2890  109 PAGAPPRVLDLGTGSGAIALAlAKERPDARVTAVDISPDALAVARRNAERLGLEDrVRFLQGDLFEpLPGDGR--FDLIV 186


                 ....
gi 187960035 125 MNPP 128
Cdd:COG2890  187 SNPP 190
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 55-126 2.96e-08

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 51.84  E-value: 2.96e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 187960035  55 VADLGCGCGVLSIGAAMLGAGLCVGFDIDEDALEIFNKNVEEFELTNVDMIQCDVYSLSSRMSKLFDTVIMN 126
Cdd:COG0500   30 VLDLGCGTGRNLLALAARFGGRVIGIDLSPEAIALARARAAKAGLGNVEFLVADLAELDPLPAESFDLVVAF 101
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 55-126 5.10e-07

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 47.41  E-value: 5.10e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 187960035   55 VADLGCGCGVLSIGAAMLGAGLC--VGFDIDEDALEIFNKNVEEFELTNVDMIQCDVYSLSSRMSKL-FDTVIMN 126
Cdd:pfam13847   7 VLDLGCGTGHLSFELAEELGPNAevVGIDISEEAIEKARENAQKLGFDNVEFEQGDIEELPELLEDDkFDVVISN 81
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 55-126 5.25e-07

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 47.30  E-value: 5.25e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 187960035  55 VADLGCGCGVLSIGAAMLGAgLCVGFDIDEDALEIFNKNVEEFELtNVDMIQCDVYSLSSRmSKLFDTVIMN 126
Cdd:COG2226   26 VLDLGCGTGRLALALAERGA-RVTGVDISPEMLELARERAAEAGL-NVEFVVGDAEDLPFP-DGSFDLVISS 94
PRK14968 PRK14968
putative methyltransferase; Provisional
 49-190 1.01e-06

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 47.20  E-value: 1.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187960035  49 DIESKAVADLGCGCGVLSIGAAMLGAGLcVGFDIDEDALEIFNKNVEEFELTN--VDMIQCDVysLSSRMSKLFDTVIMN 126
Cdd:PRK14968  21 DKKGDRVLEVGTGSGIVAIVAAKNGKKV-VGVDINPYAVECAKCNAKLNNIRNngVEVIRSDL--FEPFRGDKFDVILFN 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187960035 127 PPF-----GTKNNKGTDMA-------------FLKTA---LGMARTaVYSLHKSST-REHIQKKAAEWKVKTEIIAELRY 184
Cdd:PRK14968  98 PPYlpteeEEEWDDWLNYAlsggkdgrevidrFLDEVgryLKPGGR-ILLLQSSLTgEDEVLEYLEKLGFEAEVVAEEKF 176


                 ....*.
gi 187960035 185 DLPALY 190
Cdd:PRK14968 177 PFEELI 182
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 48-128 1.78e-06

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 47.48  E-value: 1.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187960035  48 DDIESKAVADLGCGCGVLSIGAAmLGAGLCVGFDIDEDALEIFNKNVEEFELTNVDMIQCDVYSLSSRMSKL--FDTVIM 125
Cdd:COG2265  230 DLTGGERVLDLYCGVGTFALPLA-RRAKKVIGVEIVPEAVEDARENARLNGLKNVEFVAGDLEEVLPELLWGgrPDVVVL 308


                 ...
gi 187960035 126 NPP 128
Cdd:COG2265  309 DPP 311
Nnt1 COG3897
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, ...
 47-95 1.39e-05

Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443104 [Multi-domain]  Cd Length: 216  Bit Score: 44.10  E-value: 1.39e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 187960035  47 YDDIESKAVADLGCGCGVLSIGAAMLGAGLCVGFDIDEDALEIFNKNVE 95
Cdd:COG3897   66 HPEVAGKRVLELGCGLGLVGIAAAKAGAADVTATDYDPEALAALRLNAA 114
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
53-124 3.13e-05

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 43.49  E-value: 3.13e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 187960035  53 KAVADLGCGCGVLSIGAAMLGAGLCVGFDIDEDALEIFNKNVEEFELT-NVDMIQCDVYSLssRMSKLFDTVI 124
Cdd:COG4076   37 DVVLDIGTGSGLLSMLAARAGAKKVYAVEVNPDIAAVARRIIAANGLSdRITVINADATDL--DLPEKADVII 107
rsmC PRK09489
16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;
46-151 3.79e-05

16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;


Pssm-ID: 181902 [Multi-domain]  Cd Length: 342  Bit Score: 43.39  E-value: 3.79e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187960035  46 TYDDIESKAVADLGCGCGVLsigAAMLGAG-------LCvgfDIDEDALEIFNKNVEEFELTNvDMIQCDVYS-LSSRms 117
Cdd:PRK09489 191 TLTPHTKGKVLDVGCGAGVL---SAVLARHspkirltLS---DVSAAALESSRATLAANGLEG-EVFASNVFSdIKGR-- 261

                         90       100       110
                 ....*....|....*....|....*....|....
gi 187960035 118 klFDTVIMNPPFgtknNKGtdmafLKTALGMART 151
Cdd:PRK09489 262 --FDMIISNPPF----HDG-----IQTSLDAAQT 284
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 57-106 1.42e-04

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 41.69  E-value: 1.42e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 187960035  57 DLGCGCGVLSIGAAMLGAGLCV-GFDIDEDALEIFNKNVEEFELTNVDMIQ 106
Cdd:COG2242  253 DIGAGSGSVSIEAARLAPGGRVyAIERDPERAALIRANARRFGVPNVEVVE 303
UPF0020 pfam01170
Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated ...
 30-130 1.80e-04

Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated with the THUMP domain that also occurs with RNA modification domains.


Pssm-ID: 395932 [Multi-domain]  Cd Length: 184  Bit Score: 40.80  E-value: 1.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187960035   30 PTRPHIAACMLYTIHNTYDDieskAVADLGCGCGVLSIGAAMLGA------------GLCVGFDIDEDALEIFNKNVEEF 97
Cdd:pfam01170  11 PLKETLAAAMVNLAGWKPGD----PLLDPMCGSGTILIEAALMGAniapgkfdarvrAPLYGSDIDRRMVQGARLNAENA 86

                          90       100       110
                  ....*....|....*....|....*....|....
gi 187960035   98 ELTN-VDMIQCDVYSLSSRMSKlFDTVIMNPPFG 130
Cdd:pfam01170  87 GVGDlIEFVQADAADLPLLEGS-VDVIVTNPPYG 119
cbiT PRK00377
cobalt-precorrin-6Y C(15)-methyltransferase; Provisional
 55-121 2.90e-04

cobalt-precorrin-6Y C(15)-methyltransferase; Provisional


Pssm-ID: 234740  Cd Length: 198  Bit Score: 40.17  E-value: 2.90e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187960035  55 VADLGCGCGVLSIGAAML-GAGLCV-GFDIDEDALEIFNKNVEEF-ELTNVDMIQCDVYSLSSRMSKLFD 121
Cdd:PRK00377  44 ILDIGCGTGSVTVEASLLvGETGKVyAVDKDEKAINLTRRNAEKFgVLNNIVLIKGEAPEILFTINEKFD 113
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 57-126 5.18e-04

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 38.12  E-value: 5.18e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 187960035   57 DLGCGCGVLSIGAAMLGAGL-CVGFDIDEDALEIFNKNVEEFELTNVDMIQCDVYSLSSRMSKLFDTVIMN 126
Cdd:pfam08242   2 EIGCGTGTLLRALLEALPGLeYTGLDISPAALEAARERLAALGLLNAVRVELFQLDLGELDPGSFDVVVAS 72
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 55-124 6.31e-04

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 38.76  E-value: 6.31e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 187960035  55 VADLGCGCGVLSIGAAMLGAGLCVGFDIDEDALEIFNKNVEEFELTN-VDMIQCDVYSLSSRMSklFDTVI 124
Cdd:COG2230   55 VLDIGCGWGGLALYLARRYGVRVTGVTLSPEQLEYARERAAEAGLADrVEVRLADYRDLPADGQ--FDAIV 123
PRK14967 PRK14967
putative methyltransferase; Provisional
 55-129 7.50e-04

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 39.27  E-value: 7.50e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 187960035  55 VADLGCGCGVLSIGAAMLGAGLCVGFDIDEDALEIFNKNVEEFELTnVDMIQCD-VYSLSSRMsklFDTVIMNPPF 129
Cdd:PRK14967  40 VLDLCTGSGALAVAAAAAGAGSVTAVDISRRAVRSARLNALLAGVD-VDVRRGDwARAVEFRP---FDVVVSNPPY 111
RlmL COG0116
23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA ...
 78-130 7.66e-04

23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA G2445 N2-methylase RlmL is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 439886 [Multi-domain]  Cd Length: 369  Bit Score: 39.70  E-value: 7.66e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 187960035  78 VGFDIDEDALEIFNKNVEEFELTN-VDMIQCDVYSLSSRMSKlfDTVIMNPPFG 130
Cdd:COG0116  254 FGSDIDPRAIEAARENAERAGVADlIEFEQADFRDLEPPAEP--GLIITNPPYG 305
PRK15128 PRK15128
23S rRNA (cytosine(1962)-C(5))-methyltransferase RlmI;
63-128 1.15e-03

23S rRNA (cytosine(1962)-C(5))-methyltransferase RlmI;


Pssm-ID: 185082 [Multi-domain]  Cd Length: 396  Bit Score: 39.05  E-value: 1.15e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 187960035  63 GVLSIGAAMLGAGLCVGFDIDEDALEIFNKNVE--EFELTNVDMIQCDVYSLSSRM---SKLFDTVIMNPP 128
Cdd:PRK15128 232 GGFAVSALMGGCSQVVSVDTSQEALDIARQNVElnKLDLSKAEFVRDDVFKLLRTYrdrGEKFDVIVMDPP 302
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
10-126 1.16e-03

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 38.44  E-value: 1.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187960035  10 ESRLQEVDGFEKPKLLLEQyptrphiaacmlytIHNTYDDIESKAVADLGCGCGVLsiGAAMLGAGLCV-GFDIDEDALE 88
Cdd:COG4976   19 DAALVEDLGYEAPALLAEE--------------LLARLPPGPFGRVLDLGCGTGLL--GEALRPRGYRLtGVDLSEEMLA 82

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 187960035  89 IFNKNVEEFELTNVDMiqCDVYSLSSRmsklFDTVIMN 126
Cdd:COG4976   83 KAREKGVYDRLLVADL--ADLAEPDGR----FDLIVAA 114
Dcm COG0270
DNA-cytosine methylase [Replication, recombination and repair];
55-103 1.18e-03

DNA-cytosine methylase [Replication, recombination and repair];


Pssm-ID: 440040 [Multi-domain]  Cd Length: 277  Bit Score: 38.64  E-value: 1.18e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 187960035  55 VADLGCGCGVLSIGAAMLGAGLCVGFDIDEDALEIFNKNVEEFELTNVD 103
Cdd:COG0270    6 VIDLFAGAGGLSLGFEKAGFEVVFAVEIDPDACETYRANFPEAKVIEGD 54
HsdM COG0286
Type I restriction-modification system, DNA methylase subunit [Defense mechanisms];
79-136 4.46e-03

Type I restriction-modification system, DNA methylase subunit [Defense mechanisms];


Pssm-ID: 440055 [Multi-domain]  Cd Length: 243  Bit Score: 37.09  E-value: 4.46e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 187960035  79 GFDIDEDALEI--FN---KNVEEFELTNVDmiqcdvySLSSRMSKL--FDTVIMNPPFGTKNNKG 136
Cdd:COG0286   80 GQEINPTTYRLakMNlllHGIGDPNIELGD-------TLSNDGDELekFDVVLANPPFGGKWKKE 137
TRM1 COG1867
tRNA G26 N,N-dimethylase Trm1 [Translation, ribosomal structure and biogenesis]; tRNA G26 N, ...
 45-131 4.97e-03

tRNA G26 N,N-dimethylase Trm1 [Translation, ribosomal structure and biogenesis]; tRNA G26 N,N-dimethylase Trm1 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441472  Cd Length: 383  Bit Score: 37.16  E-value: 4.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187960035  45 NTYDDIESKA--VADLGCGCGVLSIGAAmLGAGLCVGF-DIDEDALEIFNKNVEEFELTNVDMIQCDVYSLSSRMSKLFD 121
Cdd:COG1867   49 RAYRERLKREisYLDALAASGIRGLRYA-LEVGIKVTLnDIDPEAVELIRENLELNGLEDVEVYNRDANALLHELGRRFD 127

                         90
                 ....*....|
gi 187960035 122 TVIMNpPFGT 131
Cdd:COG1867  128 VVDLD-PFGS 136
Cyt_C5_DNA_methylase cd00315
Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many ...
 55-128 6.42e-03

Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG dinucleotide, has profound effects on the mammalian genome. These effects include transcriptional repression via inhibition of transcription factor binding or the recruitment of methyl-binding proteins and their associated chromatin remodeling factors, X chromosome inactivation, imprinting and the suppression of parasitic DNA sequences. DNA methylation is also essential for proper embryonic development and is an important player in both DNA repair and genome stability.


Pssm-ID: 238192 [Multi-domain]  Cd Length: 275  Bit Score: 36.44  E-value: 6.42e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 187960035  55 VADLGCGCGVLSIGAAMLGAGLCVGFDIDEDALEIFNKNveeFeltNVDMIQCDVYSLSSRMSKL-FDTVIMNPP 128
Cdd:cd00315    3 VIDLFAGIGGFRLGLEKAGFEIVAANEIDKSAAETYEAN---F---PNKLIEGDITKIDEKDFIPdIDLLTGGFP 71
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
55-126 7.30e-03

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 34.80  E-value: 7.30e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 187960035  55 VADLGCGCGVLSIG-AAMLGAGLCVGFDIDEDALEIFNKNveefeLTNVDMIQCDVYSLSSRMSklFDTVIMN 126
Cdd:COG4106    5 VLDLGCGTGRLTALlAERFPGARVTGVDLSPEMLARARAR-----LPNVRFVVADLRDLDPPEP--FDLVVSN 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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