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Conserved domains on  [gi|169234894|ref|NP_001108530|]
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protocadherin-18a precursor [Danio rerio]

Protein Classification

protocadherin( domain architecture ID 13228088)

protocadherin may have tightly regulated functions in the development, regionalization, and functional differentiation of the central nervous system

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172|18430161
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 251-351 7.89e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 113.95  E-value: 7.89e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234894  251 SYVINLLENSPLGSLLIDLNATDPDEGTNGKIIYSFSSHVSPKIletFKINSDNGHLTLMRKVDFESTNSYDIDVQAQDM 330
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGL---FSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|.
gi 169234894  331 GPNSMPAHCKVIIKVVDVNDN 351
Cdd:cd11304    78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 471-572 3.07e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 112.41  E-value: 3.07e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234894  471 YEISKAENNSPGAYLSSVKASDPDLGPNGQVSYSILesmvhGSSISTYVTIDPSNGDIYALRTFDREDVSQISFLVQARD 550
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV-----SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATD 76

                          90       100
                  ....*....|....*....|..
gi 169234894  551 SGNPPLRSNVTVVLTVLDENDN 572
Cdd:cd11304    77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 142-243 9.76e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.39  E-value: 9.76e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234894  142 VIPIEISETAAVGTRIPLDSATDPDVGENSLNTYSLT---PSGFFKIDiltRTDGakyaELVVLKELDREVRASYELQLT 218
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSID---PSTG----EITTAKPLDREEQSSYTLTVT 73

                          90       100
                  ....*....|....*....|....*
gi 169234894  219 ASDRGVPPKFGTTLLKISIADSNDN 243
Cdd:cd11304    74 ATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 368-462 7.02e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 99.70  E-value: 7.02e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234894  368 AYISETAPVDTFVALVSVNDLDSGLNGEVECRLYGQ---GHFRLQksyEKNYMILTNVTLDREKRSEFSLTVIAEDKGSP 444
Cdd:cd11304     4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGnedGLFSID---PSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 169234894  445 SLSTIKNFIVEVQDENDN 462
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 588-676 2.05e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 78.51  E-value: 2.05e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234894  588 VPVSKYAEIGDVVTVVRAMDHDAGANGDLSCSVVGGNEAGYFNMDPKTCEIRTNVSIQEVPQDHVELTILVQDHGTPTLS 667
Cdd:cd11304     4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83


                  ....*....
gi 169234894  668 ARALLRLSL 676
Cdd:cd11304    84 STATVTITV 92
Cadherin_2 super family cl29227
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 30-112 7.49e-08

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


The actual alignment was detected with superfamily member pfam08266:

Pssm-ID: 462413  Cd Length: 83  Bit Score: 50.60  E-value: 7.49e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234894    30 TLKYQVYEEQKVGTVIARLREDVADVLSKLPSSiplRFRAMQRGSASLLSVRDQDGEISIRTKIDREKLCEKNLNCTIEF 109
Cdd:pfam08266    1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAAR---GARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHF 77


                   ...
gi 169234894   110 DVL 112
Cdd:pfam08266   78 QVL 80
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 251-351 7.89e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 113.95  E-value: 7.89e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234894  251 SYVINLLENSPLGSLLIDLNATDPDEGTNGKIIYSFSSHVSPKIletFKINSDNGHLTLMRKVDFESTNSYDIDVQAQDM 330
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGL---FSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|.
gi 169234894  331 GPNSMPAHCKVIIKVVDVNDN 351
Cdd:cd11304    78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 471-572 3.07e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 112.41  E-value: 3.07e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234894  471 YEISKAENNSPGAYLSSVKASDPDLGPNGQVSYSILesmvhGSSISTYVTIDPSNGDIYALRTFDREDVSQISFLVQARD 550
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV-----SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATD 76

                          90       100
                  ....*....|....*....|..
gi 169234894  551 SGNPPLRSNVTVVLTVLDENDN 572
Cdd:cd11304    77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 142-243 9.76e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.39  E-value: 9.76e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234894  142 VIPIEISETAAVGTRIPLDSATDPDVGENSLNTYSLT---PSGFFKIDiltRTDGakyaELVVLKELDREVRASYELQLT 218
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSID---PSTG----EITTAKPLDREEQSSYTLTVT 73

                          90       100
                  ....*....|....*....|....*
gi 169234894  219 ASDRGVPPKFGTTLLKISIADSNDN 243
Cdd:cd11304    74 ATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 368-462 7.02e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 99.70  E-value: 7.02e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234894  368 AYISETAPVDTFVALVSVNDLDSGLNGEVECRLYGQ---GHFRLQksyEKNYMILTNVTLDREKRSEFSLTVIAEDKGSP 444
Cdd:cd11304     4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGnedGLFSID---PSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 169234894  445 SLSTIKNFIVEVQDENDN 462
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 489-574 2.15e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 97.81  E-value: 2.15e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234894    489 KASDPDLGPNGQVSYSILesmvhGSSISTYVTIDPSNGDIYALRTFDREDVSQISFLVQARDSGNPPLRSNVTVVLTVLD 568
Cdd:smart00112    1 SATDADSGENGKVTYSIL-----SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                    ....*.
gi 169234894    569 ENDNRP 574
Cdd:smart00112   76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 270-353 8.47e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.41  E-value: 8.47e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234894    270 NATDPDEGTNGKIIYSFSSHVSPKIletFKINSDNGHLTLMRKVDFESTNSYDIDVQAQDMGPNSMPAHCKVIIKVVDVN 349
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGL---FSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 169234894    350 DNKP 353
Cdd:smart00112   78 DNAP 81
Cadherin pfam00028
Cadherin domain;
252-345 2.63e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.50  E-value: 2.63e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234894   252 YVINLLENSPLGSLLIDLNATDPDEGTNGKIIYSFSSHVSPKIletFKINSDNGHLTLMRKVDFESTNSYDIDVQAQDMG 331
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN---FRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....
gi 169234894   332 PNSMPAHCKVIIKV 345
Cdd:pfam00028   78 GPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
471-567 5.73e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 82.73  E-value: 5.73e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234894   471 YEISKAENNSPGAYLSSVKASDPDLGPNGQVSYSILESMVHGSsistyVTIDPSNGDIYALRTFDREDVSQISFLVQARD 550
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN-----FRIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                           90
                   ....*....|....*..
gi 169234894   551 SGNPPLRSNVTVVLTVL 567
Cdd:pfam00028   76 SGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 161-245 7.98e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.01  E-value: 7.98e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234894    161 SATDPDVGENSLNTYSLTPS---GFFKIDiltRTDGakyaELVVLKELDREVRASYELQLTASDRGVPPKFGTTLLKISI 237
Cdd:smart00112    1 SATDADSGENGKVTYSILSGnddGLFSID---PETG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITV 73


                    ....*...
gi 169234894    238 ADSNDNNP 245
Cdd:smart00112   74 LDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
143-237 1.74e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.19  E-value: 1.74e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234894   143 IPIEISETAAVGTRIPLDSATDPDVGENSLNTYSLT---PSGFFKIDILTRtdgakyaELVVLKELDREVRASYELQLTA 219
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILgggPGGNFRIDPDTG-------DISTTKPLDRESIGEYELTVEA 73

                           90
                   ....*....|....*...
gi 169234894   220 SDRGVPPKFGTTLLKISI 237
Cdd:pfam00028   74 TDSGGPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 384-464 1.05e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.55  E-value: 1.05e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234894    384 SVNDLDSGLNGEVECRL---YGQGHFRLQksyEKNYMILTNVTLDREKRSEFSLTVIAEDKGSPSLSTIKNFIVEVQDEN 460
Cdd:smart00112    1 SATDADSGENGKVTYSIlsgNDDGLFSID---PETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 169234894    461 DNAP 464
Cdd:smart00112   78 DNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 588-676 2.05e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 78.51  E-value: 2.05e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234894  588 VPVSKYAEIGDVVTVVRAMDHDAGANGDLSCSVVGGNEAGYFNMDPKTCEIRTNVSIQEVPQDHVELTILVQDHGTPTLS 667
Cdd:cd11304     4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83


                  ....*....
gi 169234894  668 ARALLRLSL 676
Cdd:cd11304    84 STATVTITV 92
Cadherin pfam00028
Cadherin domain;
368-457 3.70e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.17  E-value: 3.70e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234894   368 AYISETAPVDTFVALVSVNDLDSGLNGEVECRLYGQ---GHFRLQKSyekNYMILTNVTLDREKRSEFSLTVIAEDKGSP 444
Cdd:pfam00028    3 ASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGgpgGNFRIDPD---TGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 169234894   445 SLSTIKNFIVEVQ 457
Cdd:pfam00028   80 PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 604-676 1.36e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 64.29  E-value: 1.36e-12
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 169234894    604 RAMDHDAGANGDLSCSVVGGNEAGYFNMDPKTCEIRTNVSIQEVPQDHVELTILVQDHGTPTLSARALLRLSL 676
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITV 73
Cadherin pfam00028
Cadherin domain;
594-676 1.52e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.55  E-value: 1.52e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234894   594 AEIGDVVTVVRAMDHDAGANGDLSCSVVGGNEAGYFNMDPKTCEIRTNVSIQEVPQDHVELTILVQDHGTPTLSARALLR 673
Cdd:pfam00028    9 APVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVT 88


                   ...
gi 169234894   674 LSL 676
Cdd:pfam00028   89 ITV 91
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 30-112 7.49e-08

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 50.60  E-value: 7.49e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234894    30 TLKYQVYEEQKVGTVIARLREDVADVLSKLPSSiplRFRAMQRGSASLLSVRDQDGEISIRTKIDREKLCEKNLNCTIEF 109
Cdd:pfam08266    1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAAR---GARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHF 77


                   ...
gi 169234894   110 DVL 112
Cdd:pfam08266   78 QVL 80
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 33-134 1.13e-06

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 48.08  E-value: 1.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234894   33 YQVYEEQKVGTVIARLR-EDvADvlskLPSSIPLRFRAMQRGSASLLSVRDQDGEISIRTKIDREKLCEKNLncTIE-FD 110
Cdd:cd11304     4 VSVPENAPPGTVVLTVSaTD-PD----SGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTL--TVTaTD 76

                          90       100
                  ....*....|....*....|....
gi 169234894  111 VLTLPteHLQLFHIEVEILDINDN 134
Cdd:cd11304    77 GGGPP--LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 60-136 1.74e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 38.48  E-value: 1.74e-03
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 169234894     60 PSSIPLRFRAMQRGSASLLSVRDQDGEISIRTKIDREKLCEKNLNCTIEfDVLTLPTEHLQLFHIEVeiLDINDNAP 136
Cdd:smart00112    8 GENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEAT-DGGGPPLSSTATVTITV--LDVNDNAP 81
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 251-351 7.89e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 113.95  E-value: 7.89e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234894  251 SYVINLLENSPLGSLLIDLNATDPDEGTNGKIIYSFSSHVSPKIletFKINSDNGHLTLMRKVDFESTNSYDIDVQAQDM 330
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGL---FSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|.
gi 169234894  331 GPNSMPAHCKVIIKVVDVNDN 351
Cdd:cd11304    78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 471-572 3.07e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 112.41  E-value: 3.07e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234894  471 YEISKAENNSPGAYLSSVKASDPDLGPNGQVSYSILesmvhGSSISTYVTIDPSNGDIYALRTFDREDVSQISFLVQARD 550
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV-----SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATD 76

                          90       100
                  ....*....|....*....|..
gi 169234894  551 SGNPPLRSNVTVVLTVLDENDN 572
Cdd:cd11304    77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 142-243 9.76e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.39  E-value: 9.76e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234894  142 VIPIEISETAAVGTRIPLDSATDPDVGENSLNTYSLT---PSGFFKIDiltRTDGakyaELVVLKELDREVRASYELQLT 218
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSID---PSTG----EITTAKPLDREEQSSYTLTVT 73

                          90       100
                  ....*....|....*....|....*
gi 169234894  219 ASDRGVPPKFGTTLLKISIADSNDN 243
Cdd:cd11304    74 ATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 368-462 7.02e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 99.70  E-value: 7.02e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234894  368 AYISETAPVDTFVALVSVNDLDSGLNGEVECRLYGQ---GHFRLQksyEKNYMILTNVTLDREKRSEFSLTVIAEDKGSP 444
Cdd:cd11304     4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGnedGLFSID---PSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 169234894  445 SLSTIKNFIVEVQDENDN 462
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 489-574 2.15e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 97.81  E-value: 2.15e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234894    489 KASDPDLGPNGQVSYSILesmvhGSSISTYVTIDPSNGDIYALRTFDREDVSQISFLVQARDSGNPPLRSNVTVVLTVLD 568
Cdd:smart00112    1 SATDADSGENGKVTYSIL-----SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                    ....*.
gi 169234894    569 ENDNRP 574
Cdd:smart00112   76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 270-353 8.47e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.41  E-value: 8.47e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234894    270 NATDPDEGTNGKIIYSFSSHVSPKIletFKINSDNGHLTLMRKVDFESTNSYDIDVQAQDMGPNSMPAHCKVIIKVVDVN 349
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGL---FSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 169234894    350 DNKP 353
Cdd:smart00112   78 DNAP 81
Cadherin pfam00028
Cadherin domain;
252-345 2.63e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.50  E-value: 2.63e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234894   252 YVINLLENSPLGSLLIDLNATDPDEGTNGKIIYSFSSHVSPKIletFKINSDNGHLTLMRKVDFESTNSYDIDVQAQDMG 331
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN---FRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....
gi 169234894   332 PNSMPAHCKVIIKV 345
Cdd:pfam00028   78 GPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
471-567 5.73e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 82.73  E-value: 5.73e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234894   471 YEISKAENNSPGAYLSSVKASDPDLGPNGQVSYSILESMVHGSsistyVTIDPSNGDIYALRTFDREDVSQISFLVQARD 550
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN-----FRIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                           90
                   ....*....|....*..
gi 169234894   551 SGNPPLRSNVTVVLTVL 567
Cdd:pfam00028   76 SGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 161-245 7.98e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.01  E-value: 7.98e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234894    161 SATDPDVGENSLNTYSLTPS---GFFKIDiltRTDGakyaELVVLKELDREVRASYELQLTASDRGVPPKFGTTLLKISI 237
Cdd:smart00112    1 SATDADSGENGKVTYSILSGnddGLFSID---PETG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITV 73


                    ....*...
gi 169234894    238 ADSNDNNP 245
Cdd:smart00112   74 LDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
143-237 1.74e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.19  E-value: 1.74e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234894   143 IPIEISETAAVGTRIPLDSATDPDVGENSLNTYSLT---PSGFFKIDILTRtdgakyaELVVLKELDREVRASYELQLTA 219
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILgggPGGNFRIDPDTG-------DISTTKPLDRESIGEYELTVEA 73

                           90
                   ....*....|....*...
gi 169234894   220 SDRGVPPKFGTTLLKISI 237
Cdd:pfam00028   74 TDSGGPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 384-464 1.05e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.55  E-value: 1.05e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234894    384 SVNDLDSGLNGEVECRL---YGQGHFRLQksyEKNYMILTNVTLDREKRSEFSLTVIAEDKGSPSLSTIKNFIVEVQDEN 460
Cdd:smart00112    1 SATDADSGENGKVTYSIlsgNDDGLFSID---PETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 169234894    461 DNAP 464
Cdd:smart00112   78 DNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 588-676 2.05e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 78.51  E-value: 2.05e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234894  588 VPVSKYAEIGDVVTVVRAMDHDAGANGDLSCSVVGGNEAGYFNMDPKTCEIRTNVSIQEVPQDHVELTILVQDHGTPTLS 667
Cdd:cd11304     4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83


                  ....*....
gi 169234894  668 ARALLRLSL 676
Cdd:cd11304    84 STATVTITV 92
Cadherin pfam00028
Cadherin domain;
368-457 3.70e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.17  E-value: 3.70e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234894   368 AYISETAPVDTFVALVSVNDLDSGLNGEVECRLYGQ---GHFRLQKSyekNYMILTNVTLDREKRSEFSLTVIAEDKGSP 444
Cdd:pfam00028    3 ASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGgpgGNFRIDPD---TGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 169234894   445 SLSTIKNFIVEVQ 457
Cdd:pfam00028   80 PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 604-676 1.36e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 64.29  E-value: 1.36e-12
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 169234894    604 RAMDHDAGANGDLSCSVVGGNEAGYFNMDPKTCEIRTNVSIQEVPQDHVELTILVQDHGTPTLSARALLRLSL 676
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITV 73
Cadherin pfam00028
Cadherin domain;
594-676 1.52e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.55  E-value: 1.52e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234894   594 AEIGDVVTVVRAMDHDAGANGDLSCSVVGGNEAGYFNMDPKTCEIRTNVSIQEVPQDHVELTILVQDHGTPTLSARALLR 673
Cdd:pfam00028    9 APVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVT 88


                   ...
gi 169234894   674 LSL 676
Cdd:pfam00028   89 ITV 91
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 30-112 7.49e-08

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 50.60  E-value: 7.49e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234894    30 TLKYQVYEEQKVGTVIARLREDVADVLSKLPSSiplRFRAMQRGSASLLSVRDQDGEISIRTKIDREKLCEKNLNCTIEF 109
Cdd:pfam08266    1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAAR---GARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHF 77


                   ...
gi 169234894   110 DVL 112
Cdd:pfam08266   78 QVL 80
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 33-134 1.13e-06

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 48.08  E-value: 1.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234894   33 YQVYEEQKVGTVIARLR-EDvADvlskLPSSIPLRFRAMQRGSASLLSVRDQDGEISIRTKIDREKLCEKNLncTIE-FD 110
Cdd:cd11304     4 VSVPENAPPGTVVLTVSaTD-PD----SGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTL--TVTaTD 76

                          90       100
                  ....*....|....*....|....
gi 169234894  111 VLTLPteHLQLFHIEVEILDINDN 134
Cdd:cd11304    77 GGGPP--LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 60-136 1.74e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 38.48  E-value: 1.74e-03
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 169234894     60 PSSIPLRFRAMQRGSASLLSVRDQDGEISIRTKIDREKLCEKNLNCTIEfDVLTLPTEHLQLFHIEVeiLDINDNAP 136
Cdd:smart00112    8 GENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEAT-DGGGPPLSSTATVTITV--LDVNDNAP 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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