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Conserved domains on  [gi|1677538754|ref|NP_001119580|]
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solute carrier family 12 member 3 isoform 3 [Homo sapiens]

Protein Classification

solute carrier family 12 protein( domain architecture ID 11489985)

solute carrier family 12 protein similar to Arabidopsis thaliana cation-chloride cotransporter 1, which mediates both potassium-chloride and sodium-chloride cotransports and is involved in plant development and Cl(-) homeostasis

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
59-1020 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


:

Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1610.54  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754   59 NTIDVVPTYEHYANSTQPGEPRKVRPTLADLHSFLKQEGRHLHALAFDSRPSHEMTDGLVEGEAGTSSEKNPEEPVRFGW 138
Cdd:TIGR00930    1 NTVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVVSLLGPLADYTNNGQGMKEHEEAEDAEGTKEKPPAGAVKFGW 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  139 VKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGS 218
Cdd:TIGR00930   81 VMGVLVPCLLNIWGVILFLRLSWIVGQAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGS 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  219 IGLIFAFANAVGVAMHTVGFAETVRDLLQEYGAPI-VDPINDIRIIAVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSF 297
Cdd:TIGR00930  161 IGLIFAFANAVAVAMYVVGFAETVLDLLRENGSKImVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLFLVIVLLSI 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  298 ANYLVGTLIPPSeDKASKGFFSYRADIFVQNLVPDWRGPDGTFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLM 377
Cdd:TIGR00930  241 LNIFVGTIIPAF-DKPAKGFFGLGNEIFSENFIPGIPGPEGGFFSLFGIFFPSVTGILAGANISGDLKDPQKAIPKGTLL 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  378 AIFWTTISYLAISATIGSCVVRDASGVLNDTVTPgwgACEGLACsygwnFTECTQQhSCHYGLINYYQTMSMVSGFAPLI 457
Cdd:TIGR00930  320 AILTTTVVYLGSVVLFGACVVRDATGDKNDTLVT---NCTSAAC-----FSECAHN-TCSYGLMNNLQVMSLVSPFPPLI 390
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  458 TAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFL 537
Cdd:TIGR00930  391 TAGIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYGKNGEPLRAYLLTAFIAEGFILIAELNTIAPIISNFFL 470
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  538 CSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQ 617
Cdd:TIGR00930  471 ASYALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPDVNWGSSTQ 550
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  618 AGSYNLALSYSVGLNEVEDHIKNYRPQCLVLTGPPNFRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIANGHT 697
Cdd:TIGR00930  551 ALSYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPPVCRPALLDFASQFTKGKGLMICGSVIQGPRLECVKEAQAAEAKIQ 630
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  698 KWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNWQSAHPATVEDYIGILHDAFDFNYGVCVMRMR 777
Cdd:TIGR00930  631 TWLEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWRQAEPRAWETYIGIIHDAFDAHLAVVVVRNS 710
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  778 EGLNVSkMMQAHINPVFDPAEDGKEASARVDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWS 857
Cdd:TIGR00930  711 EGLPIS-VLQVQEELENDCSEDSIELNDGKISTQPDMHLEASTQFQKKQGKGTIDVWWLVDDGGLTLLLPYLLTTKKVWK 789
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  858 KCKIRVFVGGQ-INRMDQERKAIISLLSKFRLGFHEVHILPDINQNPRAEHTKRFEDMIAPFRLNDGFKDEATVN-EMRR 935
Cdd:TIGR00930  790 KCKIRIFVGAQkDDRSEQEKKDMATLLYKFRIDAEVIVVLMDINAKPQTESMEAFEEMIRPFRLHKTEKDREAKDpKMTW 869
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  936 DCPWKISDEEITKNRVKSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLrPPVILIRGNQENV 1015
Cdd:TIGR00930  870 TKPWKITDAELQSNVRKSYRQVRLNELLLEYSRDAALVVLSLPVPRKGSIPDELYMAWLEVLSEDL-PPVLLVRGNHRNV 948

                   ....*
gi 1677538754 1016 LTFYC 1020
Cdd:TIGR00930  949 LTFYS 953
 
Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
59-1020 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1610.54  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754   59 NTIDVVPTYEHYANSTQPGEPRKVRPTLADLHSFLKQEGRHLHALAFDSRPSHEMTDGLVEGEAGTSSEKNPEEPVRFGW 138
Cdd:TIGR00930    1 NTVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVVSLLGPLADYTNNGQGMKEHEEAEDAEGTKEKPPAGAVKFGW 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  139 VKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGS 218
Cdd:TIGR00930   81 VMGVLVPCLLNIWGVILFLRLSWIVGQAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGS 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  219 IGLIFAFANAVGVAMHTVGFAETVRDLLQEYGAPI-VDPINDIRIIAVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSF 297
Cdd:TIGR00930  161 IGLIFAFANAVAVAMYVVGFAETVLDLLRENGSKImVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLFLVIVLLSI 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  298 ANYLVGTLIPPSeDKASKGFFSYRADIFVQNLVPDWRGPDGTFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLM 377
Cdd:TIGR00930  241 LNIFVGTIIPAF-DKPAKGFFGLGNEIFSENFIPGIPGPEGGFFSLFGIFFPSVTGILAGANISGDLKDPQKAIPKGTLL 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  378 AIFWTTISYLAISATIGSCVVRDASGVLNDTVTPgwgACEGLACsygwnFTECTQQhSCHYGLINYYQTMSMVSGFAPLI 457
Cdd:TIGR00930  320 AILTTTVVYLGSVVLFGACVVRDATGDKNDTLVT---NCTSAAC-----FSECAHN-TCSYGLMNNLQVMSLVSPFPPLI 390
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  458 TAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFL 537
Cdd:TIGR00930  391 TAGIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYGKNGEPLRAYLLTAFIAEGFILIAELNTIAPIISNFFL 470
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  538 CSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQ 617
Cdd:TIGR00930  471 ASYALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPDVNWGSSTQ 550
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  618 AGSYNLALSYSVGLNEVEDHIKNYRPQCLVLTGPPNFRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIANGHT 697
Cdd:TIGR00930  551 ALSYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPPVCRPALLDFASQFTKGKGLMICGSVIQGPRLECVKEAQAAEAKIQ 630
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  698 KWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNWQSAHPATVEDYIGILHDAFDFNYGVCVMRMR 777
Cdd:TIGR00930  631 TWLEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWRQAEPRAWETYIGIIHDAFDAHLAVVVVRNS 710
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  778 EGLNVSkMMQAHINPVFDPAEDGKEASARVDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWS 857
Cdd:TIGR00930  711 EGLPIS-VLQVQEELENDCSEDSIELNDGKISTQPDMHLEASTQFQKKQGKGTIDVWWLVDDGGLTLLLPYLLTTKKVWK 789
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  858 KCKIRVFVGGQ-INRMDQERKAIISLLSKFRLGFHEVHILPDINQNPRAEHTKRFEDMIAPFRLNDGFKDEATVN-EMRR 935
Cdd:TIGR00930  790 KCKIRIFVGAQkDDRSEQEKKDMATLLYKFRIDAEVIVVLMDINAKPQTESMEAFEEMIRPFRLHKTEKDREAKDpKMTW 869
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  936 DCPWKISDEEITKNRVKSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLrPPVILIRGNQENV 1015
Cdd:TIGR00930  870 TKPWKITDAELQSNVRKSYRQVRLNELLLEYSRDAALVVLSLPVPRKGSIPDELYMAWLEVLSEDL-PPVLLVRGNHRNV 948

                   ....*
gi 1677538754 1016 LTFYC 1020
Cdd:TIGR00930  949 LTFYS 953
SLC12 pfam03522
Solute carrier family 12;
655-1020 6.47e-169

Solute carrier family 12;


Pssm-ID: 460955  Cd Length: 414  Bit Score: 500.99  E-value: 6.47e-169
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  655 RPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPElQLIANGHtKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMK 734
Cdd:pfam03522    1 RPALVDFAHLITKNVSLMICGHVVKGRLSQKLRS-ELQKKAY-RWLRKRKIKAFYALVDGDNLREGAQALLQASGLGKLK 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  735 PNILVVGFKKNWQSAHPATVEDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQ--------------AHINPVFDPAEDG 800
Cdd:pfam03522   79 PNILLMGYKSDWRTCDKEELEEYFNVIHDAFDLQYAVAILRLPEGLDVSHLLQdqdteelglgdetnSSYAEQSSEEQST 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  801 KEASARVDPKALVKEEQ--------------------------------------------ATTIFQSEQGKKTIDIYWL 836
Cdd:pfam03522  159 SNSKQDDDKSKLSKKDSnlslspdkstknpsgkdssksdklkkkspsiilrtasnekeilnNITQFQKKQKKGTIDVWWL 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  837 FDDGGLTLLIPYLLGRKRRWSKCKIRVFVGG-QINRMDQERKAIISLLSKFRLGFHEVHILPDINQNPRAEHTKRFEDMI 915
Cdd:pfam03522  239 YDDGGLTLLLPYILSTRSKWSDCKLRVFALGnRKDELEEEQRNMASLLSKFRIDYSDLTVIPDITKKPKKETKKFFDELI 318
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  916 APFRLNDGFKDEATVnemrrdcpWKISDEEITKNRVKSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLE 995
Cdd:pfam03522  319 EPFRLHEDDKEEESA--------EKITDSELEALKEKTNRQLRLRELLLEHSSDANLIVMTLPMPRKGTVSAPLYMAWLE 390
                          410       420
                   ....*....|....*....|....*
gi 1677538754  996 TLSQDLrPPVILIRGNQENVLTFYC 1020
Cdd:pfam03522  391 TLTKDL-PPFLLVRGNQTSVLTFYS 414
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
125-607 7.76e-34

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 135.80  E-value: 7.76e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  125 SSEKNPEEPVRFGWVKGVMIrCMLNIWGVILYLrLPWITAQAGIVLTWIIILLSVTVTSITGLSISAISTNgKVKSGGTY 204
Cdd:COG0531      2 SRGESSELKRKLGLFDLVAL-GVGAIIGAGIFV-LPGLAAGLAGPAAILAWLIAGLLALLVALSYAELASA-FPRAGGAY 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  205 FLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAETVRDLLqeygapivdPINDIRIIAVVSVTVLLAISLAGMEWESK 284
Cdd:COG0531     79 TYARRALGPLLGFLAGWALLLSYVLAVAAVAVAFGGYLSSLF---------PAGGSVLIALVLILLLTLLNLRGVKESAK 149
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  285 AQVLFFLVIMVSFANYLVGtlippsedkaskGFFSYRADIFvQNLVPDWRGPDGTFFGMFSIFFpSATGILAGANISGDL 364
Cdd:COG0531    150 VNNILTVLKLLVLLLFIVV------------GLFAFDPANF-TPFLPAGGGLSGVLAALALAFF-AFTGFEAIANLAEEA 215
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  365 KDPAIAIPKGTLMAIFWTTISYLAISATIGSCVvrdASGVLNDTVTPgwgaceglacsygwnftectqqhschyglinYY 444
Cdd:COG0531    216 KNPKRNIPRAIILSLLIVGVLYILVSLALTGVV---PYDELAASGAP-------------------------------LA 261
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  445 QTMSMVSG--FAPLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPliGFFGKGYGKNKEPVRGYLLAY--AIAVAFI 520
Cdd:COG0531    262 DAAEAVFGpwGAILIALGALLSLLGALNASILGASRLLYAMARDGLLP--KVFAKVHPRFGTPVNAILLTGviALLLLLL 339
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  521 IIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPsFQYYNKWAALFGAIISVVIMFLLTWWAALIAIGVVLF-L 599
Cdd:COG0531    340 GAASFTALASLASVGVLLAYLLVALAVIVLRRRRPDLPRP-FRVPLPLIPILGILLCLFLLYLLGPGALLIGLVLLAIgL 418

                   ....*...
gi 1677538754  600 LLYVIYKK 607
Cdd:COG0531    419 LLYLLYRR 426
 
Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
59-1020 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1610.54  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754   59 NTIDVVPTYEHYANSTQPGEPRKVRPTLADLHSFLKQEGRHLHALAFDSRPSHEMTDGLVEGEAGTSSEKNPEEPVRFGW 138
Cdd:TIGR00930    1 NTVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVVSLLGPLADYTNNGQGMKEHEEAEDAEGTKEKPPAGAVKFGW 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  139 VKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGS 218
Cdd:TIGR00930   81 VMGVLVPCLLNIWGVILFLRLSWIVGQAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGS 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  219 IGLIFAFANAVGVAMHTVGFAETVRDLLQEYGAPI-VDPINDIRIIAVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSF 297
Cdd:TIGR00930  161 IGLIFAFANAVAVAMYVVGFAETVLDLLRENGSKImVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLFLVIVLLSI 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  298 ANYLVGTLIPPSeDKASKGFFSYRADIFVQNLVPDWRGPDGTFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLM 377
Cdd:TIGR00930  241 LNIFVGTIIPAF-DKPAKGFFGLGNEIFSENFIPGIPGPEGGFFSLFGIFFPSVTGILAGANISGDLKDPQKAIPKGTLL 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  378 AIFWTTISYLAISATIGSCVVRDASGVLNDTVTPgwgACEGLACsygwnFTECTQQhSCHYGLINYYQTMSMVSGFAPLI 457
Cdd:TIGR00930  320 AILTTTVVYLGSVVLFGACVVRDATGDKNDTLVT---NCTSAAC-----FSECAHN-TCSYGLMNNLQVMSLVSPFPPLI 390
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  458 TAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFL 537
Cdd:TIGR00930  391 TAGIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYGKNGEPLRAYLLTAFIAEGFILIAELNTIAPIISNFFL 470
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  538 CSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQ 617
Cdd:TIGR00930  471 ASYALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPDVNWGSSTQ 550
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  618 AGSYNLALSYSVGLNEVEDHIKNYRPQCLVLTGPPNFRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIANGHT 697
Cdd:TIGR00930  551 ALSYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPPVCRPALLDFASQFTKGKGLMICGSVIQGPRLECVKEAQAAEAKIQ 630
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  698 KWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNWQSAHPATVEDYIGILHDAFDFNYGVCVMRMR 777
Cdd:TIGR00930  631 TWLEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWRQAEPRAWETYIGIIHDAFDAHLAVVVVRNS 710
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  778 EGLNVSkMMQAHINPVFDPAEDGKEASARVDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWS 857
Cdd:TIGR00930  711 EGLPIS-VLQVQEELENDCSEDSIELNDGKISTQPDMHLEASTQFQKKQGKGTIDVWWLVDDGGLTLLLPYLLTTKKVWK 789
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  858 KCKIRVFVGGQ-INRMDQERKAIISLLSKFRLGFHEVHILPDINQNPRAEHTKRFEDMIAPFRLNDGFKDEATVN-EMRR 935
Cdd:TIGR00930  790 KCKIRIFVGAQkDDRSEQEKKDMATLLYKFRIDAEVIVVLMDINAKPQTESMEAFEEMIRPFRLHKTEKDREAKDpKMTW 869
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  936 DCPWKISDEEITKNRVKSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLrPPVILIRGNQENV 1015
Cdd:TIGR00930  870 TKPWKITDAELQSNVRKSYRQVRLNELLLEYSRDAALVVLSLPVPRKGSIPDELYMAWLEVLSEDL-PPVLLVRGNHRNV 948

                   ....*
gi 1677538754 1016 LTFYC 1020
Cdd:TIGR00930  949 LTFYS 953
SLC12 pfam03522
Solute carrier family 12;
655-1020 6.47e-169

Solute carrier family 12;


Pssm-ID: 460955  Cd Length: 414  Bit Score: 500.99  E-value: 6.47e-169
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  655 RPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPElQLIANGHtKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMK 734
Cdd:pfam03522    1 RPALVDFAHLITKNVSLMICGHVVKGRLSQKLRS-ELQKKAY-RWLRKRKIKAFYALVDGDNLREGAQALLQASGLGKLK 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  735 PNILVVGFKKNWQSAHPATVEDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQ--------------AHINPVFDPAEDG 800
Cdd:pfam03522   79 PNILLMGYKSDWRTCDKEELEEYFNVIHDAFDLQYAVAILRLPEGLDVSHLLQdqdteelglgdetnSSYAEQSSEEQST 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  801 KEASARVDPKALVKEEQ--------------------------------------------ATTIFQSEQGKKTIDIYWL 836
Cdd:pfam03522  159 SNSKQDDDKSKLSKKDSnlslspdkstknpsgkdssksdklkkkspsiilrtasnekeilnNITQFQKKQKKGTIDVWWL 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  837 FDDGGLTLLIPYLLGRKRRWSKCKIRVFVGG-QINRMDQERKAIISLLSKFRLGFHEVHILPDINQNPRAEHTKRFEDMI 915
Cdd:pfam03522  239 YDDGGLTLLLPYILSTRSKWSDCKLRVFALGnRKDELEEEQRNMASLLSKFRIDYSDLTVIPDITKKPKKETKKFFDELI 318
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  916 APFRLNDGFKDEATVnemrrdcpWKISDEEITKNRVKSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLE 995
Cdd:pfam03522  319 EPFRLHEDDKEEESA--------EKITDSELEALKEKTNRQLRLRELLLEHSSDANLIVMTLPMPRKGTVSAPLYMAWLE 390
                          410       420
                   ....*....|....*....|....*
gi 1677538754  996 TLSQDLrPPVILIRGNQENVLTFYC 1020
Cdd:pfam03522  391 TLTKDL-PPFLLVRGNQTSVLTFYS 414
AA_permease pfam00324
Amino acid permease;
141-646 1.22e-116

Amino acid permease;


Pssm-ID: 366028 [Multi-domain]  Cd Length: 467  Bit Score: 366.65  E-value: 1.22e-116
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  141 GVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVTVTSITGLSISAISTNGKVkSGGTYFLISRSLGPELGGSIG 220
Cdd:pfam00324    1 HVQMIALGGVIGTGLFVGSGSVLGQAGPAGALLGYLISGVVIFLVMLSLGEISTNGPV-SGGFYTYASRFLGPSLGFATG 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  221 L------IFAFANAVGVAMHTVGFAETVRDLLQEYgapivdpindirIIAVVSVTVLLAISLAGMEWESKAQVLFFLVIM 294
Cdd:pfam00324   80 WnywlswITVLALELTAASILIQFWELVPDIPYLW------------VWGAVFLVLLTIINLVGVKWYGEAEFWFALIKI 147
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  295 VSFANYLVGTLIPPSEDKASKG--FFSYRADIFVQNLVPDWRGPdgtFFGMFSIFFPSATGILAGANISGDLKDPAIAIP 372
Cdd:pfam00324  148 IAIIGFIIVGIILLSGGNPNDGaiFRYLGDNGGKNNFPPGFGKG---FISVFVIAFFAFTGIELVGIAAGEVKNPEKSIP 224
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  373 KGTLMAIFWTTISYLAISATIGSCVVRDASGVLNDTVTPgwgaceglacsygwnftectqqhschYGLINYYQTMSMVSG 452
Cdd:pfam00324  225 KAILQVIWRITIFYILSLLAIGLLVPWNDPGLLNDSASA--------------------------ASPFVIFFKFLGISG 278
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  453 FAPLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPligFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIapII 532
Cdd:pfam00324  279 LAPLINAVILTAALSAANSSLYSGSRMLYSLARDGLAP---KFLKKVDKRGVPLRAILVSMVISLLALLLASLNPA--IV 353
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  533 SNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNW 612
Cdd:pfam00324  354 FNFLLAISGLSGLIVWGLISLSHLRFRKAFKYQGRSIDELPFKAPLGPLGVILGLAAIIIILIIQFLYAFLPVPGGPKNW 433
                          490       500       510
                   ....*....|....*....|....*....|....
gi 1677538754  613 GSSVQAGSYNLALSYSVGLNEVEDHIKNYRPQCL 646
Cdd:pfam00324  434 GAGSFAAAYLIVLLFLIILIGVKLHVKNWKPQLL 467
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
125-607 7.76e-34

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 135.80  E-value: 7.76e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  125 SSEKNPEEPVRFGWVKGVMIrCMLNIWGVILYLrLPWITAQAGIVLTWIIILLSVTVTSITGLSISAISTNgKVKSGGTY 204
Cdd:COG0531      2 SRGESSELKRKLGLFDLVAL-GVGAIIGAGIFV-LPGLAAGLAGPAAILAWLIAGLLALLVALSYAELASA-FPRAGGAY 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  205 FLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAETVRDLLqeygapivdPINDIRIIAVVSVTVLLAISLAGMEWESK 284
Cdd:COG0531     79 TYARRALGPLLGFLAGWALLLSYVLAVAAVAVAFGGYLSSLF---------PAGGSVLIALVLILLLTLLNLRGVKESAK 149
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  285 AQVLFFLVIMVSFANYLVGtlippsedkaskGFFSYRADIFvQNLVPDWRGPDGTFFGMFSIFFpSATGILAGANISGDL 364
Cdd:COG0531    150 VNNILTVLKLLVLLLFIVV------------GLFAFDPANF-TPFLPAGGGLSGVLAALALAFF-AFTGFEAIANLAEEA 215
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  365 KDPAIAIPKGTLMAIFWTTISYLAISATIGSCVvrdASGVLNDTVTPgwgaceglacsygwnftectqqhschyglinYY 444
Cdd:COG0531    216 KNPKRNIPRAIILSLLIVGVLYILVSLALTGVV---PYDELAASGAP-------------------------------LA 261
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  445 QTMSMVSG--FAPLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPliGFFGKGYGKNKEPVRGYLLAY--AIAVAFI 520
Cdd:COG0531    262 DAAEAVFGpwGAILIALGALLSLLGALNASILGASRLLYAMARDGLLP--KVFAKVHPRFGTPVNAILLTGviALLLLLL 339
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  521 IIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPsFQYYNKWAALFGAIISVVIMFLLTWWAALIAIGVVLF-L 599
Cdd:COG0531    340 GAASFTALASLASVGVLLAYLLVALAVIVLRRRRPDLPRP-FRVPLPLIPILGILLCLFLLYLLGPGALLIGLVLLAIgL 418

                   ....*...
gi 1677538754  600 LLYVIYKK 607
Cdd:COG0531    419 LLYLLYRR 426
AA_permease_N pfam08403
Amino acid permease N-terminal; This domain is found to the N-terminus of the amino acid ...
45-116 7.59e-29

Amino acid permease N-terminal; This domain is found to the N-terminus of the amino acid permease domain (pfam00324) in metazoan Na-K-Cl cotransporters.


Pssm-ID: 429977  Cd Length: 70  Bit Score: 109.84  E-value: 7.59e-29
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1677538754   45 LTHSSTFCMRTFGYNTIDVVPTYEHYANSTQPGEPRKVRPTLADLHSFLkQEGRHLhALAFDSRPSHEMTDG 116
Cdd:pfam08403    1 DTHGSTYYLQTFGHNTLDAVPRIDFYRNTGSVSGVKKSRPSLAELHSQL-KKNSAL-AVAEGSVDGVENGDG 70
AA_permease_2 pfam13520
Amino acid permease;
166-604 4.89e-13

Amino acid permease;


Pssm-ID: 404414 [Multi-domain]  Cd Length: 427  Bit Score: 72.34  E-value: 4.89e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  166 AGIVLTWIIILLSVTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAETvrdL 245
Cdd:pfam13520   27 SGGPALIVWGWIAAIIFSLAVGLVYAELSSALPRSGGIYVYLENAFGKFVAFLAGWSNWFAYVLGLASSASVAASY---L 103
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  246 LQEYGAPIVDPINDIRIIAVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSFANYLVGTLIPpsedKASKGFFSYRADIF 325
Cdd:pfam13520  104 LSALGPDLVPTTWLTYGIAIAILIIFAIINIRGVRESAKIQNILGILKLLLPLILIIILGLV----TADGGGFNLLSGEW 179
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  326 VQNLVPDWrgpDGTFFGMFSIFFpSATGILAGANISGDLKDPaiAIPKGTLMAIFWTTISYLAISATIGSCVVRDASGVL 405
Cdd:pfam13520  180 HTFFPDGW---PGVFAGFLGVLW-SFTGFESAANVSEEVKKR--NVPKAIFIGVIIVGVLYILVNIAFFGVVPDDEIALS 253
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  406 NDTVTPGwgaceGLacsygwnftectqqhschyglinyYQTMSMVSGFAPLITAGIFGATLSSALACLVSAAKVFQCLCE 485
Cdd:pfam13520  254 SGLGQVA-----AL------------------------LFQAVGGKWGAIIVVILLALSLLGAVNTAIVGASRLLYALAR 304
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677538754  486 DQLYPLIGFFGKgYGKNKEPVRGYLLAY-----AIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRP 560
Cdd:pfam13520  305 DGVLPFSRFFAK-VNKFGSPIRAIILTAilsliLLLLFLLSPAAYNALLSLSAYGYLLSYLLPIIGLLILRKKRPDLGRI 383
                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....
gi 1677538754  561 sfqYYNKWAALFGAIISVVIMFLLTWWAALIAIGVVLFLLLYVI 604
Cdd:pfam13520  384 ---PGRWPVAIFGILFSLFLIVALFFPPVGPATGSSLNYAIILI 424
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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