|
Name |
Accession |
Description |
Interval |
E-value |
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
436-645 |
1.09e-113 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 347.66 E-value: 1.09e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 436 LMPFQRAGVNFAIAKGGRLLLADDMGLGKTIQAICIAAFYRKEWPLLVVVPSSVRFTWEQAFLRWLPSLSPDCINVVVTG 515
Cdd:cd18010 1 LLPFQREGVCFALRRGGRVLIADEMGLGKTVQAIAIAAYYREEWPLLIVCPSSLRLTWADEIERWLPSLPPDDIQVIVKS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 516 KDRLTAG--LINIVSFDLLSKLEKQL-KTPFKVVIIDESHFLKNSRTARCRAAMPVLKVAKRVILLSGTPAMSRPAELYT 592
Cdd:cd18010 81 KDGLRDGdaKVVIVSYDLLRRLEKQLlARKFKVVICDESHYLKNSKAKRTKAALPLLKRAKRVILLSGTPALSRPIELFT 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 187761314 593 QIIAVKPTFFPQFHAFGLRYCDAKRMPWGWDYSGSSNLGELKLLLEEAVMLRR 645
Cdd:cd18010 161 QLDALDPKLFGRFHDFGRRYCAAKQGGFGWDYSGSSNLEELHLLLLATIMIRR 213
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
423-856 |
4.25e-84 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 285.20 E-value: 4.25e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 423 ADLSEVDPKLVSNLMPFQRAGVNFAIAK---GGRLLLADDMGLGKTIQAICIAAFYRKE---WPLLVVVPSSVRFTWEQA 496
Cdd:COG0553 229 EALESLPAGLKATLRPYQLEGAAWLLFLrrlGLGGLLADDMGLGKTIQALALLLELKERglaRPVLIVAPTSLVGNWQRE 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 497 FLRWLPSLSPdcinVVVTGKDRLTAGL-------INIVSFDLLSKLEKQLK-TPFKVVIIDESHFLKNSRTARCRAAMpV 568
Cdd:COG0553 309 LAKFAPGLRV----LVLDGTRERAKGAnpfedadLVITSYGLLRRDIELLAaVDWDLVILDEAQHIKNPATKRAKAVR-A 383
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 569 LKvAKRVILLSGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRYCDAKRmpwgwdySGSSNLGELKLLLEEAVMLRRLKS 648
Cdd:COG0553 384 LK-ARHRLALTGTPVENRLEELWSLLDFLNPGLLGSLKAFRERFARPIE-------KGDEEALERLRRLLRPFLLRRTKE 455
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 649 DVLSQLPAKQRKIVVIAPGRINART-RAALDAAAKEMTTKDKTKQQQK--DALI----------LFFNRTAEAKIPS--- 712
Cdd:COG0553 456 DVLKDLPEKTEETLYVELTPEQRALyEAVLEYLRRELEGAEGIRRRGLilAALTrlrqicshpaLLLEEGAELSGRSakl 535
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 713 --VIEYILDLLESGrEKFLVFAHHKVVLDAITQELERKHVQHIRIDGSTSSAEREDLCQQFQLSERHAVAVLSITAANMG 790
Cdd:COG0553 536 eaLLELLEELLAEG-EKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPEAPVFLISLKAGGEG 614
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 187761314 791 LTFSSADLVVFAELFWNPGVLIQAEDRVHRIGQTSSVGIHYLVAKGTADDYLWPLIQEKIKvLAEA 856
Cdd:COG0553 615 LNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRA-LAES 679
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
708-833 |
7.81e-46 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 160.72 E-value: 7.81e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 708 AKIPSVIEYILDLLESGrEKFLVFAHHKVVLDAITQELERKHVQHIRIDGSTSSAEREDLCQQFQLSERHAVAVLSITAA 787
Cdd:cd18793 11 GKLEALLELLEELREPG-EKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIRVFLLSTKAG 89
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 187761314 788 NMGLTFSSADLVVFAELFWNPGVLIQAEDRVHRIGQTSSVGIHYLV 833
Cdd:cd18793 90 GVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
|
|
| HARP |
pfam07443 |
HepA-related protein (HARP); This family represents a conserved region approximately 60 ... |
248-302 |
1.33e-28 |
|
HepA-related protein (HARP); This family represents a conserved region approximately 60 residues long within eukaryotic HepA-related protein (HARP). This exhibits single-stranded DNA-dependent ATPase activity, and is ubiquitously expressed in human and mouse tissues. Family members may contain more than one copy of this region.
Pssm-ID: 462166 Cd Length: 55 Bit Score: 108.79 E-value: 1.33e-28
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 187761314 248 FQVLIGYNAELIAVFKTLPSKNYDPDTKTWNFSMNDYSALMKAAQSLPTVNLQPL 302
Cdd:pfam07443 1 FEVEIGYHAELIAVFKQMPSRNYDPKTKKWNFSLEDYSKLMEAARALPQVELEPL 55
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
439-850 |
1.12e-26 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 117.59 E-value: 1.12e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 439 FQRAGVNFAI---AKGGRLLLADDMGLGKTIQAICIAAF---YRK-EWPLLVVVPSSVRFTWEQAFLRWLPSLSPdcINV 511
Cdd:PLN03142 173 YQLAGLNWLIrlyENGINGILADEMGLGKTLQTISLLGYlheYRGiTGPHMVVAPKSTLGNWMNEIRRFCPVLRA--VKF 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 512 VVTGKDR-------LTAGLINIV--SFDLLSKLEKQLKT-PFKVVIIDESHFLKNSRTaRCRAAMPVLKVAKRvILLSGT 581
Cdd:PLN03142 251 HGNPEERahqreelLVAGKFDVCvtSFEMAIKEKTALKRfSWRYIIIDEAHRIKNENS-LLSKTMRLFSTNYR-LLITGT 328
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 582 PAMSRPAELYTQIIAVKPTFFPQFHAFGlrycdakrmpwGWDYSGSSNLGELKLLLEEAV----MLRRLKSDVLSQLPAK 657
Cdd:PLN03142 329 PLQNNLHELWALLNFLLPEIFSSAETFD-----------EWFQISGENDQQEVVQQLHKVlrpfLLRRLKSDVEKGLPPK 397
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 658 QRKIVVIAPGRINARTRAAL--------DAAAKEMTTKDKTKQQQKDALILFFNRTAEAKIP-----SVIE-----YILD 719
Cdd:PLN03142 398 KETILKVGMSQMQKQYYKALlqkdldvvNAGGERKRLLNIAMQLRKCCNHPYLFQGAEPGPPyttgeHLVEnsgkmVLLD 477
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 720 -LLESGREK---FLVFAHHKVVLDAITQELERKHVQHIRIDGSTSSAEREDLCQQFQL--SERHaVAVLSITAANMGLTF 793
Cdd:PLN03142 478 kLLPKLKERdsrVLIFSQMTRLLDILEDYLMYRGYQYCRIDGNTGGEDRDASIDAFNKpgSEKF-VFLLSTRAGGLGINL 556
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 187761314 794 SSADLVVFAELFWNPGVLIQAEDRVHRIGQTSSVGIHYLVAKGTaddylwplIQEKI 850
Cdd:PLN03142 557 ATADIVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTEYT--------IEEKV 605
|
|
| HARP |
pfam07443 |
HepA-related protein (HARP); This family represents a conserved region approximately 60 ... |
343-397 |
1.48e-25 |
|
HepA-related protein (HARP); This family represents a conserved region approximately 60 residues long within eukaryotic HepA-related protein (HARP). This exhibits single-stranded DNA-dependent ATPase activity, and is ubiquitously expressed in human and mouse tissues. Family members may contain more than one copy of this region.
Pssm-ID: 462166 Cd Length: 55 Bit Score: 99.94 E-value: 1.48e-25
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 187761314 343 FEADISYSQDLIALFKQMDSRRYDVKTRKWSFLLEEHSKLIAKVRCLPQVQLDPL 397
Cdd:pfam07443 1 FEVEIGYHAELIAVFKQMPSRNYDPKTKKWNFSLEDYSKLMEAARALPQVELEPL 55
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
440-662 |
1.85e-22 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 98.52 E-value: 1.85e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 440 QRAGVNFAIAK------GGrlLLADDMGLGKTIQAICIAAF---YRKEW--PLLVVVPSSVRFTWEQAFLRWL--PSLSP 506
Cdd:pfam00176 2 QIEGVNWMLSLennlgrGG--ILADEMGLGKTLQTISLLLYlkhVDKNWggPTLIVVPLSLLHNWMNEFERWVspPALRV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 507 DCI-------NVVVTGKDRLTAGLINIVSFDLLSKLEKQL-KTPFKVVIIDESHFLKNSRtARCRAAMPVLKVAKRvILL 578
Cdd:pfam00176 80 VVLhgnkrpqERWKNDPNFLADFDVVITTYETLRKHKELLkKVHWHRIVLDEGHRLKNSK-SKLSKALKSLKTRNR-WIL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 579 SGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRYCDAKRMPwgwdysGSSNLGELKLLLEEAVMLRRLKSDVLSQLPAKQ 658
Cdd:pfam00176 158 TGTPLQNNLEELWALLNFLRPGPFGSLSTFRNWFDRPIERG------GGKKGVSRLHKLLKPFLLRRTKKDVEKSLPPKV 231
|
....
gi 187761314 659 RKIV 662
Cdd:pfam00176 232 EYIL 235
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
712-822 |
6.26e-19 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 83.03 E-value: 6.26e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 712 SVIEYILDLLESGR-EKFLVFAHHKVVLDAiTQELERKHVQHIRIDGSTSSAEREDLCQQFQLSERHAVavLSITAANMG 790
Cdd:pfam00271 1 EKLEALLELLKKERgGKVLIFSQTKKTLEA-ELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVL--VATDVAERG 77
|
90 100 110
....*....|....*....|....*....|..
gi 187761314 791 LTFSSADLVVFAELFWNPGVLIQAEDRVHRIG 822
Cdd:pfam00271 78 LDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
428-582 |
2.62e-18 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 84.08 E-value: 2.62e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 428 VDPKLVSNLMPFQRAGVNFAIAKGGRLLLADDMGLGKTIQA---ICIAAFYRKEWPLLVVVP-SSVRFTWEQAFLRWLPS 503
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSGLRDVILAAPTGSGKTLAAllpALEALKRGKGGRVLVLVPtRELAEQWAEELKKLGPS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 504 LSPDCINVVVTGK-----DRLTAGLINIV-----SFDLLSKLEKQLKTPFKVVIIDESHFLKN-SRTARCRAAMPVLKVA 572
Cdd:smart00487 81 LGLKVVGLYGGDSkreqlRKLESGKTDILvttpgRLLDLLENDKLSLSNVDLVILDEAHRLLDgGFGDQLEKLLKLLPKN 160
|
170
....*....|
gi 187761314 573 KRVILLSGTP 582
Cdd:smart00487 161 VQLLLLSATP 170
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
739-822 |
1.19e-15 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 72.63 E-value: 1.19e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 739 DAITQELERKHVQHIRIDGSTSSAEREDLCQQFQlsERHAVAVLSITAANMGLTFSSADLVVFAELFWNPGVLIQAEDRV 818
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFN--NGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRA 78
|
....
gi 187761314 819 HRIG 822
Cdd:smart00490 79 GRAG 82
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
436-820 |
1.63e-12 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 71.21 E-value: 1.63e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 436 LMPFQRAGVNFAIA----KGGRLLLADDMGLGKTIQAICIAAFYRKEWPLLVVVPS-SVRFTWEQAFLRWLPslspdciN 510
Cdd:COG1061 81 LRPYQQEALEALLAalerGGGRGLVVAPTGTGKTVLALALAAELLRGKRVLVLVPRrELLEQWAEELRRFLG-------D 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 511 VVVTGKDRLTAGLINIVSFDLLSKLE--KQLKTPFKVVIIDESHFLKNSRTARCRAAMPvlkvAKRVILLSGTP----AM 584
Cdd:COG1061 154 PLAGGGKKDSDAPITVATYQSLARRAhlDELGDRFGLVIIDEAHHAGAPSYRRILEAFP----AAYRLGLTATPfrsdGR 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 585 SRPAELYTQIIavkptffpqfhaFGLRYCDAkrmpwgwdysgssnlgelkllleeavmlrrLKSDVLSQlpakqrkivvi 664
Cdd:COG1061 230 EILLFLFDGIV------------YEYSLKEA------------------------------IEDGYLAP----------- 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 665 apgrinARTRAALDAAAKEMTTKDKTKQQQKDALIlffnRTAEAKIPSVIEYILDllESGREKFLVFAHHKVVLDAITQE 744
Cdd:COG1061 257 ------PEYYGIRVDLTDERAEYDALSERLREALA----ADAERKDKILRELLRE--HPDDRKTLVFCSSVDHAEALAEL 324
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 187761314 745 LERKHVQHIRIDGSTSSAEREDLCQQFqlSERHAVAVLSITAANMGLTFSSADLVVFAELFWNPGVLIQAEDRVHR 820
Cdd:COG1061 325 LNEAGIRAAVVTGDTPKKEREEILEAF--RDGELRILVTVDVLNEGVDVPRLDVAILLRPTGSPREFIQRLGRGLR 398
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
709-904 |
3.04e-03 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 41.40 E-value: 3.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 709 KIPSVIEYILD-LLESGREKFLVFAHHKVVLDAITQELERKHVQHIRIDGSTSSAEREDLCQQFQL-------SERHAVA 780
Cdd:PRK13766 348 KLEKLREIVKEqLGKNPDSRIIVFTQYRDTAEKIVDLLEKEGIKAVRFVGQASKDGDKGMSQKEQIeildkfrAGEFNVL 427
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 781 VlSITAANMGLTFSSADLVVFAElfwnPgvlIQAEDR-VHRIGQT--SSVG-IHYLVAKGTADD-YLWPLI------QEK 849
Cdd:PRK13766 428 V-STSVAEEGLDIPSVDLVIFYE----P---VPSEIRsIQRKGRTgrQEEGrVVVLIAKGTRDEaYYWSSRrkekkmKEE 499
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 187761314 850 IKVLAEAgLSETNFSEMTESTDYLYKDPKQQKIYDlFQKSFEKEGSDMELLEAAE 904
Cdd:PRK13766 500 LKNLKGI-LNKKLQELDEEQKGEEEEKDEQLSLDD-FVKSKGKEEEEEEEKEEKD 552
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
436-645 |
1.09e-113 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 347.66 E-value: 1.09e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 436 LMPFQRAGVNFAIAKGGRLLLADDMGLGKTIQAICIAAFYRKEWPLLVVVPSSVRFTWEQAFLRWLPSLSPDCINVVVTG 515
Cdd:cd18010 1 LLPFQREGVCFALRRGGRVLIADEMGLGKTVQAIAIAAYYREEWPLLIVCPSSLRLTWADEIERWLPSLPPDDIQVIVKS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 516 KDRLTAG--LINIVSFDLLSKLEKQL-KTPFKVVIIDESHFLKNSRTARCRAAMPVLKVAKRVILLSGTPAMSRPAELYT 592
Cdd:cd18010 81 KDGLRDGdaKVVIVSYDLLRRLEKQLlARKFKVVICDESHYLKNSKAKRTKAALPLLKRAKRVILLSGTPALSRPIELFT 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 187761314 593 QIIAVKPTFFPQFHAFGLRYCDAKRMPWGWDYSGSSNLGELKLLLEEAVMLRR 645
Cdd:cd18010 161 QLDALDPKLFGRFHDFGRRYCAAKQGGFGWDYSGSSNLEELHLLLLATIMIRR 213
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
423-856 |
4.25e-84 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 285.20 E-value: 4.25e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 423 ADLSEVDPKLVSNLMPFQRAGVNFAIAK---GGRLLLADDMGLGKTIQAICIAAFYRKE---WPLLVVVPSSVRFTWEQA 496
Cdd:COG0553 229 EALESLPAGLKATLRPYQLEGAAWLLFLrrlGLGGLLADDMGLGKTIQALALLLELKERglaRPVLIVAPTSLVGNWQRE 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 497 FLRWLPSLSPdcinVVVTGKDRLTAGL-------INIVSFDLLSKLEKQLK-TPFKVVIIDESHFLKNSRTARCRAAMpV 568
Cdd:COG0553 309 LAKFAPGLRV----LVLDGTRERAKGAnpfedadLVITSYGLLRRDIELLAaVDWDLVILDEAQHIKNPATKRAKAVR-A 383
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 569 LKvAKRVILLSGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRYCDAKRmpwgwdySGSSNLGELKLLLEEAVMLRRLKS 648
Cdd:COG0553 384 LK-ARHRLALTGTPVENRLEELWSLLDFLNPGLLGSLKAFRERFARPIE-------KGDEEALERLRRLLRPFLLRRTKE 455
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 649 DVLSQLPAKQRKIVVIAPGRINART-RAALDAAAKEMTTKDKTKQQQK--DALI----------LFFNRTAEAKIPS--- 712
Cdd:COG0553 456 DVLKDLPEKTEETLYVELTPEQRALyEAVLEYLRRELEGAEGIRRRGLilAALTrlrqicshpaLLLEEGAELSGRSakl 535
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 713 --VIEYILDLLESGrEKFLVFAHHKVVLDAITQELERKHVQHIRIDGSTSSAEREDLCQQFQLSERHAVAVLSITAANMG 790
Cdd:COG0553 536 eaLLELLEELLAEG-EKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPEAPVFLISLKAGGEG 614
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 187761314 791 LTFSSADLVVFAELFWNPGVLIQAEDRVHRIGQTSSVGIHYLVAKGTADDYLWPLIQEKIKvLAEA 856
Cdd:COG0553 615 LNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRA-LAES 679
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
708-833 |
7.81e-46 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 160.72 E-value: 7.81e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 708 AKIPSVIEYILDLLESGrEKFLVFAHHKVVLDAITQELERKHVQHIRIDGSTSSAEREDLCQQFQLSERHAVAVLSITAA 787
Cdd:cd18793 11 GKLEALLELLEELREPG-EKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIRVFLLSTKAG 89
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 187761314 788 NMGLTFSSADLVVFAELFWNPGVLIQAEDRVHRIGQTSSVGIHYLV 833
Cdd:cd18793 90 GVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
|
|
| DEXHc_Snf |
cd17919 |
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ... |
436-602 |
8.39e-46 |
|
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350677 [Multi-domain] Cd Length: 182 Bit Score: 162.35 E-value: 8.39e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 436 LMPFQRAGVNFAI---AKGGRLLLADDMGLGKTIQAICIAAFYRKE----WPLLVVVPSSVRFTWEQAFLRWLPSLSPdc 508
Cdd:cd17919 1 LRPYQLEGLNFLLelyENGPGGILADEMGLGKTLQAIAFLAYLLKEgkerGPVLVVCPLSVLENWEREFEKWTPDLRV-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 509 inVVVTG----------KDRLTAGLINIVSFDLLSKLEKQL-KTPFKVVIIDESHFLKNSRTARCRAAMPVLkvAKRVIL 577
Cdd:cd17919 79 --VVYHGsqreraqiraKEKLDKFDVVLTTYETLRRDKASLrKFRWDLVVVDEAHRLKNPKSQLSKALKALR--AKRRLL 154
|
170 180
....*....|....*....|....*
gi 187761314 578 LSGTPAMSRPAELYTQIIAVKPTFF 602
Cdd:cd17919 155 LTGTPLQNNLEELWALLDFLDPPFL 179
|
|
| HARP |
pfam07443 |
HepA-related protein (HARP); This family represents a conserved region approximately 60 ... |
248-302 |
1.33e-28 |
|
HepA-related protein (HARP); This family represents a conserved region approximately 60 residues long within eukaryotic HepA-related protein (HARP). This exhibits single-stranded DNA-dependent ATPase activity, and is ubiquitously expressed in human and mouse tissues. Family members may contain more than one copy of this region.
Pssm-ID: 462166 Cd Length: 55 Bit Score: 108.79 E-value: 1.33e-28
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 187761314 248 FQVLIGYNAELIAVFKTLPSKNYDPDTKTWNFSMNDYSALMKAAQSLPTVNLQPL 302
Cdd:pfam07443 1 FEVEIGYHAELIAVFKQMPSRNYDPKTKKWNFSLEDYSKLMEAARALPQVELEPL 55
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
439-850 |
1.12e-26 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 117.59 E-value: 1.12e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 439 FQRAGVNFAI---AKGGRLLLADDMGLGKTIQAICIAAF---YRK-EWPLLVVVPSSVRFTWEQAFLRWLPSLSPdcINV 511
Cdd:PLN03142 173 YQLAGLNWLIrlyENGINGILADEMGLGKTLQTISLLGYlheYRGiTGPHMVVAPKSTLGNWMNEIRRFCPVLRA--VKF 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 512 VVTGKDR-------LTAGLINIV--SFDLLSKLEKQLKT-PFKVVIIDESHFLKNSRTaRCRAAMPVLKVAKRvILLSGT 581
Cdd:PLN03142 251 HGNPEERahqreelLVAGKFDVCvtSFEMAIKEKTALKRfSWRYIIIDEAHRIKNENS-LLSKTMRLFSTNYR-LLITGT 328
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 582 PAMSRPAELYTQIIAVKPTFFPQFHAFGlrycdakrmpwGWDYSGSSNLGELKLLLEEAV----MLRRLKSDVLSQLPAK 657
Cdd:PLN03142 329 PLQNNLHELWALLNFLLPEIFSSAETFD-----------EWFQISGENDQQEVVQQLHKVlrpfLLRRLKSDVEKGLPPK 397
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 658 QRKIVVIAPGRINARTRAAL--------DAAAKEMTTKDKTKQQQKDALILFFNRTAEAKIP-----SVIE-----YILD 719
Cdd:PLN03142 398 KETILKVGMSQMQKQYYKALlqkdldvvNAGGERKRLLNIAMQLRKCCNHPYLFQGAEPGPPyttgeHLVEnsgkmVLLD 477
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 720 -LLESGREK---FLVFAHHKVVLDAITQELERKHVQHIRIDGSTSSAEREDLCQQFQL--SERHaVAVLSITAANMGLTF 793
Cdd:PLN03142 478 kLLPKLKERdsrVLIFSQMTRLLDILEDYLMYRGYQYCRIDGNTGGEDRDASIDAFNKpgSEKF-VFLLSTRAGGLGINL 556
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 187761314 794 SSADLVVFAELFWNPGVLIQAEDRVHRIGQTSSVGIHYLVAKGTaddylwplIQEKI 850
Cdd:PLN03142 557 ATADIVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTEYT--------IEEKV 605
|
|
| DEXQc_arch_SWI2_SNF2 |
cd18012 |
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ... |
432-647 |
1.86e-26 |
|
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350770 [Multi-domain] Cd Length: 218 Bit Score: 108.42 E-value: 1.86e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 432 LVSNLMPFQRAGVNF--AIAK---GGrlLLADDMGLGKTIQAIC-IAAFYRKEW--PLLVVVPSSVRFTWEQAFLRWLPS 503
Cdd:cd18012 1 LKATLRPYQKEGFNWlsFLRHyglGG--ILADDMGLGKTLQTLAlLLSRKEEGRkgPSLVVAPTSLIYNWEEEAAKFAPE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 504 LspdciNVVV---TGKDRLTAGLIN-----IVSFDLLSKLEKQLKT-PFKVVIIDESHFLKNSRTARCRAAMpVLKVAKR 574
Cdd:cd18012 79 L-----KVLVihgTKRKREKLRALEdydlvITSYGLLRRDIELLKEvKFHYLVLDEAQNIKNPQTKTAKAVK-ALKADHR 152
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 187761314 575 vILLSGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRYcdakRMPwgWDYSGSSNLGELKLLLEEAVMLRRLK 647
Cdd:cd18012 153 -LALTGTPIENHLGELWSIFDFLNPGLLGSYKRFKKRF----AKP--IEKDGDEEALEELKKLISPFILRRLK 218
|
|
| HARP |
pfam07443 |
HepA-related protein (HARP); This family represents a conserved region approximately 60 ... |
343-397 |
1.48e-25 |
|
HepA-related protein (HARP); This family represents a conserved region approximately 60 residues long within eukaryotic HepA-related protein (HARP). This exhibits single-stranded DNA-dependent ATPase activity, and is ubiquitously expressed in human and mouse tissues. Family members may contain more than one copy of this region.
Pssm-ID: 462166 Cd Length: 55 Bit Score: 99.94 E-value: 1.48e-25
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 187761314 343 FEADISYSQDLIALFKQMDSRRYDVKTRKWSFLLEEHSKLIAKVRCLPQVQLDPL 397
Cdd:pfam07443 1 FEVEIGYHAELIAVFKQMPSRNYDPKTKKWNFSLEDYSKLMEAARALPQVELEPL 55
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
440-662 |
1.85e-22 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 98.52 E-value: 1.85e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 440 QRAGVNFAIAK------GGrlLLADDMGLGKTIQAICIAAF---YRKEW--PLLVVVPSSVRFTWEQAFLRWL--PSLSP 506
Cdd:pfam00176 2 QIEGVNWMLSLennlgrGG--ILADEMGLGKTLQTISLLLYlkhVDKNWggPTLIVVPLSLLHNWMNEFERWVspPALRV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 507 DCI-------NVVVTGKDRLTAGLINIVSFDLLSKLEKQL-KTPFKVVIIDESHFLKNSRtARCRAAMPVLKVAKRvILL 578
Cdd:pfam00176 80 VVLhgnkrpqERWKNDPNFLADFDVVITTYETLRKHKELLkKVHWHRIVLDEGHRLKNSK-SKLSKALKSLKTRNR-WIL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 579 SGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRYCDAKRMPwgwdysGSSNLGELKLLLEEAVMLRRLKSDVLSQLPAKQ 658
Cdd:pfam00176 158 TGTPLQNNLEELWALLNFLRPGPFGSLSTFRNWFDRPIERG------GGKKGVSRLHKLLKPFLLRRTKKDVEKSLPPKV 231
|
....
gi 187761314 659 RKIV 662
Cdd:pfam00176 232 EYIL 235
|
|
| DEXDc_RapA |
cd18011 |
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ... |
436-602 |
2.65e-22 |
|
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350769 [Multi-domain] Cd Length: 207 Bit Score: 95.82 E-value: 2.65e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 436 LMPFQRAGVNFAIAKG-GRLLLADDMGLGKTIQAICIAAFYRKEW---PLLVVVPSSVRFTW--EQAFLRWLPSLSPDCI 509
Cdd:cd18011 1 PLPHQIDAVLRALRKPpVRLLLADEVGLGKTIEAGLIIKELLLRGdakRVLILCPASLVEQWqdELQDKFGLPFLILDRE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 510 NV---VVTGKDRLTAGLINIVSFDLLSKLEKQ----LKTPFKVVIIDESHFLKNSR----TARCRAAMPVLKVAKRVILL 578
Cdd:cd18011 81 TAaqlRRLIGNPFEEFPIVIVSLDLLKRSEERrgllLSEEWDLVVVDEAHKLRNSGggkeTKRYKLGRLLAKRARHVLLL 160
|
170 180
....*....|....*....|....
gi 187761314 579 SGTPAMSRPAELYTQIIAVKPTFF 602
Cdd:cd18011 161 TATPHNGKEEDFRALLSLLDPGRF 184
|
|
| DEXHc_RAD54 |
cd18004 |
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ... |
436-612 |
5.08e-20 |
|
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350762 [Multi-domain] Cd Length: 240 Bit Score: 90.42 E-value: 5.08e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 436 LMPFQRAGVNF--------AIAKGGRLLLADDMGLGKTIQAICIAafyrkeWPLL--------------VVVPSSVRFTW 493
Cdd:cd18004 1 LRPHQREGVQFlydcltgrRGYGGGGAILADEMGLGKTLQAIALV------WTLLkqgpygkptakkalIVCPSSLVGNW 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 494 EQAFLRWLP-------SLSPDCINVVVTGKDRLTAGL--INIVSFDLLSKLEKQLKTP--FKVVIIDESHFLKNSRTaRC 562
Cdd:cd18004 75 KAEFDKWLGlrrikvvTADGNAKDVKASLDFFSSASTypVLIISYETLRRHAEKLSKKisIDLLICDEGHRLKNSES-KT 153
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 187761314 563 RAAMPVLKVAKRvILLSGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRY 612
Cdd:cd18004 154 TKALNSLPCRRR-LLLTGTPIQNDLDEFFALVDFVNPGILGSLASFRKVF 202
|
|
| DEXDc_SHPRH-like |
cd18008 |
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ... |
436-645 |
2.12e-19 |
|
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350766 [Multi-domain] Cd Length: 241 Bit Score: 88.50 E-value: 2.12e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 436 LMPFQRAGVNFAIAKGGrlLLADDMGLGKTIQAI-CIAA------FYRKEWPL--------------LVVVPSSVRFTWE 494
Cdd:cd18008 1 LLPYQKQGLAWMLPRGG--ILADEMGLGKTIQALaLILAtrpqdpKIPEELEEnssdpkklylskttLIVVPLSLLSQWK 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 495 Q--------AFLRWL----------PSLSPDCiNVVVTGKDRLTAGLINIVSFDLLSKLEKQ----LKTPFKVVIIDESH 552
Cdd:cd18008 79 DeiekhtkpGSLKVYvyhgskriksIEELSDY-DIVITTYGTLASEFPKNKKGGGRDSKEKEasplHRIRWYRVILDEAH 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 553 FLKNSRTARCRAAMpVLKvAKRVILLSGTPAMSRPAELYTQIIavkptfFPQFHAFGLRYCDAKRMPWGWDYsGSSNLGE 632
Cdd:cd18008 158 NIKNRSTKTSRAVC-ALK-AERRWCLTGTPIQNSLDDLYSLLR------FLRVEPFGDYPWFNSDISKPFSK-NDRKALE 228
|
250
....*....|...
gi 187761314 633 LKLLLEEAVMLRR 645
Cdd:cd18008 229 RLQALLKPILLRR 241
|
|
| DEXHc_SMARCAD1 |
cd17998 |
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ... |
436-602 |
2.72e-19 |
|
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350756 [Multi-domain] Cd Length: 187 Bit Score: 86.67 E-value: 2.72e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 436 LMPFQRAGVNFAI---AKGGRLLLADDMGLGKTIQAICIAAfYRKE----WPLLVVVPSSVRFTWEQAFLRWLPSLSPDC 508
Cdd:cd17998 1 LKDYQLIGLNWLNllyQKKLSGILADEMGLGKTIQVIAFLA-YLKEigipGPHLVVVPSSTLDNWLREFKRWCPSLKVEP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 509 ---------------------INVVVTgkdrlTAGLINIVSFDllSKLEKQLKtpFKVVIIDESHFLKNSRTARCRAAMp 567
Cdd:cd17998 80 yygsqeerkhlrydilkgledFDVIVT-----TYNLATSNPDD--RSFFKRLK--LNYVVYDEGHMLKNMTSERYRHLM- 149
|
170 180 190
....*....|....*....|....*....|....*
gi 187761314 568 VLKVAKRvILLSGTPAMSRPAELYTQIIAVKPTFF 602
Cdd:cd17998 150 TINANFR-LLLTGTPLQNNLLELMSLLNFIMPKPF 183
|
|
| DEXHc_ATRX-like |
cd18007 |
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ... |
436-602 |
3.48e-19 |
|
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350765 [Multi-domain] Cd Length: 239 Bit Score: 87.73 E-value: 3.48e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 436 LMPFQRAGVNF----------AIAKGGRLLLADDMGLGKTIQAICI-----AAFYRKEWPLlVVVPSSVRFTWEQAFLRW 500
Cdd:cd18007 1 LKPHQVEGVRFlwsnlvgtdvGSDEGGGCILAHTMGLGKTLQVITFlhtylAAAPRRSRPL-VLCPASTLYNWEDEFKKW 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 501 LPSLSPDCINVVV-----TGKDRLTA-------GLINIVSFDLLSKL--------------EKQLKTPF-KVVIIDESHF 553
Cdd:cd18007 80 LPPDLRPLLVLVSlsaskRADARLRKinkwhkeGGVLLIGYELFRNLasnattdprlkqefIAALLDPGpDLLVLDEGHR 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 187761314 554 LKNSRTARCRAAMpvlKV-AKRVILLSGTPAMSRPAELYTQIIAVKPTFF 602
Cdd:cd18007 160 LKNEKSQLSKALS---KVkTKRRILLTGTPLQNNLKEYWTMVDFARPKYL 206
|
|
| DEXHc_Mot1 |
cd17999 |
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ... |
436-591 |
5.83e-19 |
|
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350757 [Multi-domain] Cd Length: 232 Bit Score: 87.02 E-value: 5.83e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 436 LMPFQRAGVN---FAIAKGGRLLLADDMGLGKTIQAICIAA---FYRKEW------PLLVVVPSSVRFTWEQAFLRWLPS 503
Cdd:cd17999 1 LRPYQQEGINwlaFLNKYNLHGILCDDMGLGKTLQTLCILAsdhHKRANSfnsenlPSLVVCPPTLVGHWVAEIKKYFPN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 504 LSPDCINVVVTGKDR------LTAGLINIVSFDLLSKLEKQL-KTPFKVVIIDESHFLKNSRTaRCRAAMPVLKVAKRVI 576
Cdd:cd17999 81 AFLKPLAYVGPPQERrrlreqGEKHNVIVASYDVLRNDIEVLtKIEWNYCVLDEGHIIKNSKT-KLSKAVKQLKANHRLI 159
|
170
....*....|....*
gi 187761314 577 lLSGTPAMSRPAELY 591
Cdd:cd17999 160 -LSGTPIQNNVLELW 173
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
712-822 |
6.26e-19 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 83.03 E-value: 6.26e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 712 SVIEYILDLLESGR-EKFLVFAHHKVVLDAiTQELERKHVQHIRIDGSTSSAEREDLCQQFQLSERHAVavLSITAANMG 790
Cdd:pfam00271 1 EKLEALLELLKKERgGKVLIFSQTKKTLEA-ELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVL--VATDVAERG 77
|
90 100 110
....*....|....*....|....*....|..
gi 187761314 791 LTFSSADLVVFAELFWNPGVLIQAEDRVHRIG 822
Cdd:pfam00271 78 LDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEXHc_CHD6_7_8_9 |
cd17995 |
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ... |
436-616 |
1.29e-18 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350753 [Multi-domain] Cd Length: 223 Bit Score: 85.76 E-value: 1.29e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 436 LMPFQRAGVN---FAIAKGGRLLLADDMGLGKTIQAIC----IAAFYRKEWPLLVVVPSSVRFTWEQAFLRWLpslspdC 508
Cdd:cd17995 1 LRDYQLEGVNwllFNWYNRRNCILADEMGLGKTIQSIAflehLYQVEGIRGPFLVIAPLSTIPNWQREFETWT------D 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 509 INVVV---TGKDRLTAGLI-------------NIVSFDLL--------SKLEKQLKTPFKVVIIDESHFLKNsrtaRCRA 564
Cdd:cd17995 75 MNVVVyhgSGESRQIIQQYemyfkdaqgrkkkGVYKFDVLittyemviADAEELRKIPWRVVVVDEAHRLKN----RNSK 150
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 187761314 565 AMPVLKVAK--RVILLSGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRYCDAK 616
Cdd:cd17995 151 LLQGLKKLTleHKLLLTGTPLQNNTEELWSLLNFLEPEKFPSSEEFLEEFGDLK 204
|
|
| DEXQc_SRCAP |
cd18003 |
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ... |
436-608 |
1.51e-18 |
|
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350761 [Multi-domain] Cd Length: 223 Bit Score: 85.48 E-value: 1.51e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 436 LMPFQRAGVNFAIA---KGGRLLLADDMGLGKTIQAICIAAF---YRKEW-PLLVVVPSSVRFTWEQAFLRWLPSL---- 504
Cdd:cd18003 1 LREYQHIGLDWLATlyeKNLNGILADEMGLGKTIQTIALLAHlacEKGNWgPHLIVVPTSVMLNWEMEFKRWCPGFkilt 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 505 ---SPDCINVVVTGKDRLTAGLINIVSFDLLSKLEKQLK-TPFKVVIIDESHFLKNSRTARCRAampVLKV-AKRVILLS 579
Cdd:cd18003 81 yygSAKERKLKRQGWMKPNSFHVCITSYQLVVQDHQVFKrKKWKYLILDEAHNIKNFKSQRWQT---LLNFnTQRRLLLT 157
|
170 180
....*....|....*....|....*....
gi 187761314 580 GTPAMSRPAELYTQIIAVKPTFFPQFHAF 608
Cdd:cd18003 158 GTPLQNSLMELWSLMHFLMPHIFQSHQEF 186
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
428-582 |
2.62e-18 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 84.08 E-value: 2.62e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 428 VDPKLVSNLMPFQRAGVNFAIAKGGRLLLADDMGLGKTIQA---ICIAAFYRKEWPLLVVVP-SSVRFTWEQAFLRWLPS 503
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSGLRDVILAAPTGSGKTLAAllpALEALKRGKGGRVLVLVPtRELAEQWAEELKKLGPS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 504 LSPDCINVVVTGK-----DRLTAGLINIV-----SFDLLSKLEKQLKTPFKVVIIDESHFLKN-SRTARCRAAMPVLKVA 572
Cdd:smart00487 81 LGLKVVGLYGGDSkreqlRKLESGKTDILvttpgRLLDLLENDKLSLSNVDLVILDEAHRLLDgGFGDQLEKLLKLLPKN 160
|
170
....*....|
gi 187761314 573 KRVILLSGTP 582
Cdd:smart00487 161 VQLLLLSATP 170
|
|
| DEXQc_bact_SNF2 |
cd18013 |
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ... |
438-594 |
1.07e-17 |
|
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350771 [Multi-domain] Cd Length: 218 Bit Score: 82.78 E-value: 1.07e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 438 PFQRAGVNFAIA-KGGRLLLadDMGLGKT------IQAICIAAFYRkewPLLVVVPSSV-RFTWEQAFLRWlpSLSPDCI 509
Cdd:cd18013 3 PYQKVAINFIIEhPYCGLFL--DMGLGKTvttltaLSDLQLDDFTR---RVLVIAPLRVaRSTWPDEVEKW--NHLRNLT 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 510 NVVVTGKDRLTAGLIN------IVSFDLLSKLEKQLKT--PFKVVIIDESHFLKNSRTARCRAAMPVLKVAKRVILLSGT 581
Cdd:cd18013 76 VSVAVGTERQRSKAANtpadlyVINRENLKWLVNKSGDpwPFDMVVIDELSSFKSPRSKRFKALRKVRPVIKRLIGLTGT 155
|
170
....*....|...
gi 187761314 582 PAMSRPAELYTQI 594
Cdd:cd18013 156 PSPNGLMDLWAQI 168
|
|
| DEXHc_ERCC6L |
cd18001 |
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ... |
436-591 |
1.94e-17 |
|
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350759 [Multi-domain] Cd Length: 232 Bit Score: 82.42 E-value: 1.94e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 436 LMPFQRAGVNFAIA-----KGGrlLLADDMGLGKTIQAIC-IAAFYRKEW--PLLVVVPSSVRFTWEQAFLRWLPSLspd 507
Cdd:cd18001 1 LYPHQREGVAWLWSlhdggKGG--ILADDMGLGKTVQICAfLSGMFDSGLikSVLVVMPTSLIPHWVKEFAKWTPGL--- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 508 ciNVVV------TGKDR-----LTAGLINIVSFDLLSKLEKQLKTPFK------VVIIDESHFLKNS--RTARCRAAMPv 568
Cdd:cd18001 76 --RVKVfhgtskKERERnleriQRGGGVLLTTYGMVLSNTEQLSADDHdefkwdYVILDEGHKIKNSktKSAKSLREIP- 152
|
170 180
....*....|....*....|...
gi 187761314 569 lkvAKRVILLSGTPAMSRPAELY 591
Cdd:cd18001 153 ---AKNRIILTGTPIQNNLKELW 172
|
|
| DEXHc_SMARCA2_SMARCA4 |
cd17996 |
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ... |
455-608 |
1.36e-16 |
|
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350754 [Multi-domain] Cd Length: 233 Bit Score: 80.11 E-value: 1.36e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 455 LLADDMGLGKTIQAICIAA----FYRKEWPLLVVVPSSVRFTWEQAFLRWLPSL-------SPDC------------INV 511
Cdd:cd17996 26 ILADEMGLGKTIQTISLITylmeKKKNNGPYLVIVPLSTLSNWVSEFEKWAPSVskivykgTPDVrkklqsqiragkFNV 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 512 VVTG-----KDRLtaglinivsfdLLSKLEkqlktpFKVVIIDESHFLKNsrtARCRAAMpVLK---VAKRVILLSGTPA 583
Cdd:cd17996 106 LLTTyeyiiKDKP-----------LLSKIK------WKYMIIDEGHRMKN---AQSKLTQ-TLNtyyHARYRLLLTGTPL 164
|
170 180
....*....|....*....|....*
gi 187761314 584 MSRPAELYTQIIAVKPTFFPQFHAF 608
Cdd:cd17996 165 QNNLPELWALLNFLLPKIFKSCKTF 189
|
|
| DEXHc_SMARCA1_SMARCA5 |
cd17997 |
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ... |
439-608 |
3.27e-16 |
|
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350755 [Multi-domain] Cd Length: 222 Bit Score: 78.52 E-value: 3.27e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 439 FQRAGVNFAIA---KGGRLLLADDMGLGKTIQAICIAAF---YRK-EWPLLVVVPSSVRFTWEQAFLRWLPSLSPdcinV 511
Cdd:cd17997 7 YQIRGLNWLISlfeNGINGILADEMGLGKTLQTISLLGYlkhYKNiNGPHLIIVPKSTLDNWMREFKRWCPSLRV----V 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 512 VVTGKDRLTAGLIN-----------IVSFDLLSKLEKQLKT-PFKVVIIDESHFLKN-----SRTARcraampVLKVAKR 574
Cdd:cd17997 83 VLIGDKEERADIIRdvllpgkfdvcITSYEMVIKEKTVLKKfNWRYIIIDEAHRIKNeksklSQIVR------LFNSRNR 156
|
170 180 190
....*....|....*....|....*....|....
gi 187761314 575 vILLSGTPAMSRPAELYTQIIAVKPTFFPQFHAF 608
Cdd:cd17997 157 -LLLTGTPLQNNLHELWALLNFLLPDVFTSSEDF 189
|
|
| DEXHc_CHD3_4_5 |
cd17994 |
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ... |
436-614 |
7.85e-16 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350752 [Multi-domain] Cd Length: 196 Bit Score: 77.09 E-value: 7.85e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 436 LMPFQRAGVN---FAIAKGGRLLLADDMGLGKTIQAICIAAFYRKE----WPLLVVVPSSVRFTWEQAFLRWlpslSPDC 508
Cdd:cd17994 1 LHPYQLEGLNwlrFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEghskGPFLVSAPLSTIINWEREFEMW----APDF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 509 INVVVTGKDRLtaglinIVSFDLLSKLEKQLKT-PFKVVIIDESHFLKNSRTARCRaAMPVLKVAKRViLLSGTPAMSRP 587
Cdd:cd17994 77 YVVTYVGDHVL------LTSYELISIDQAILGSiDWAVLVVDEAHRLKNNQSKFFR-ILNSYKIGYKL-LLTGTPLQNNL 148
|
170 180
....*....|....*....|....*..
gi 187761314 588 AELYTQIIAVKPTFFPQFHAFGLRYCD 614
Cdd:cd17994 149 EELFHLLNFLTPERFNNLQGFLEEFAD 175
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
739-822 |
1.19e-15 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 72.63 E-value: 1.19e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 739 DAITQELERKHVQHIRIDGSTSSAEREDLCQQFQlsERHAVAVLSITAANMGLTFSSADLVVFAELFWNPGVLIQAEDRV 818
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFN--NGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRA 78
|
....
gi 187761314 819 HRIG 822
Cdd:smart00490 79 GRAG 82
|
|
| DEXHc_RAD54B |
cd18066 |
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ... |
436-599 |
1.33e-15 |
|
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350824 [Multi-domain] Cd Length: 235 Bit Score: 77.19 E-value: 1.33e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 436 LMPFQRAGVNF--------AIAKGGRLLLADDMGLGKTIQAICIAAFYRKEWP---------LLVVVPSSVRFTWEQAFL 498
Cdd:cd18066 1 LRPHQREGIEFlyecvmgmRVNERFGAILADEMGLGKTLQCISLIWTLLRQGPyggkpvikrALIVTPGSLVKNWKKEFQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 499 RWLPSlspDCINVVVTGKDRLTAGLIN-------IVSFD-LLSKLEKQLKTPFKVVIIDESHFLKNSrTARCRAAMPVLK 570
Cdd:cd18066 81 KWLGS---ERIKVFTVDQDHKVEEFIAsplysvlIISYEmLLRSLDQISKLNFDLVICDEGHRLKNT-SIKTTTALTSLS 156
|
170 180
....*....|....*....|....*....
gi 187761314 571 VAKRVIlLSGTPAMSRPAELYTQIIAVKP 599
Cdd:cd18066 157 CERRII-LTGTPIQNDLQEFFALIDFVNP 184
|
|
| DEXHc_ERCC6L2 |
cd18005 |
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ... |
436-581 |
2.52e-15 |
|
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350763 [Multi-domain] Cd Length: 245 Bit Score: 76.65 E-value: 2.52e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 436 LMPFQRAGVNF-----AIAKGGrlLLADDMGLGKTIQAIC-IAAFYRKEW-----------------------PLLVVVP 486
Cdd:cd18005 1 LRDYQREGVEFmydlyKNGRGG--ILGDDMGLGKTVQVIAfLAAVLGKTGtrrdrennrprfkkkppassakkPVLIVAP 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 487 SSVRFTWEQAFLRWlPSLSPDCINVVvtGKD-----RLTAGL--INIVSFDLLSKLEKQLKT-PFKVVIIDESHFLKNSR 558
Cdd:cd18005 79 LSVLYNWKDELDTW-GHFEVGVYHGS--RKDdelegRLKAGRleVVVTTYDTLRRCIDSLNSiNWSAVIADEAHRIKNPK 155
|
170 180
....*....|....*....|...
gi 187761314 559 TARCRaAMPVLKVaKRVILLSGT 581
Cdd:cd18005 156 SKLTQ-AMKELKC-KVRIGLTGT 176
|
|
| DEXHc_CHD1_2 |
cd17993 |
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ... |
439-582 |
5.76e-15 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350751 [Multi-domain] Cd Length: 218 Bit Score: 75.08 E-value: 5.76e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 439 FQRAGVNFAI---AKGGRLLLADDMGLGKTIQAICIAAFYRKEW----PLLVVVPSSVRFTWEQAFLRWLPSLspdciNV 511
Cdd:cd17993 5 YQLTGLNWLAhswCKGNNGILADEMGLGKTVQTISFLSYLFHSQqqygPFLVVVPLSTMPAWQREFAKWAPDM-----NV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 512 VV-TGkdrltagliNIVSFDLLSKLE------KQLK-----TPFKVVI---------------IDESHFLKNSRTArCRA 564
Cdd:cd17993 80 IVyLG---------DIKSRDTIREYEfyfsqtKKLKfnvllTTYEIILkdkaflgsikwqylaVDEAHRLKNDESL-LYE 149
|
170
....*....|....*...
gi 187761314 565 AMPVLKVAKRvILLSGTP 582
Cdd:cd17993 150 ALKEFKTNNR-LLITGTP 166
|
|
| DEXHc_HELLS_SMARCA6 |
cd18009 |
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ... |
436-608 |
9.40e-15 |
|
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350767 [Multi-domain] Cd Length: 236 Bit Score: 74.73 E-value: 9.40e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 436 LMPFQRAGVNFAIA---KGGRLLLADDMGLGKTIQAICIAAFY--RKEW-PLLVVVPSSVRFTWEQAFLRWLPSlspdcI 509
Cdd:cd18009 4 MRPYQLEGMEWLRMlweNGINGILADEMGLGKTIQTIALLAHLreRGVWgPFLVIAPLSTLPNWVNEFARFTPS-----V 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 510 NVVV---TGKDRLT-AGLIN------------IVSFDLLSKLEKQLKT-PFKVVIIDESHFLKNSrtaRCR--AAMPVLK 570
Cdd:cd18009 79 PVLLyhgTKEERERlRKKIMkregtlqdfpvvVTSYEIAMRDRKALQHyAWKYLIVDEGHRLKNL---NCRliQELKTFN 155
|
170 180 190
....*....|....*....|....*....|....*...
gi 187761314 571 VAKRvILLSGTPAMSRPAELYTQIIAVKPTFFPQFHAF 608
Cdd:cd18009 156 SDNR-LLLTGTPLQNNLSELWSLLNFLLPDVFDDLSSF 192
|
|
| DEXHc_SMARCA5 |
cd18064 |
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ... |
436-658 |
2.34e-14 |
|
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350822 [Multi-domain] Cd Length: 244 Bit Score: 73.93 E-value: 2.34e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 436 LMPFQRAGVNFAIA---KGGRLLLADDMGLGKTIQAICIAAF---YRK-EWPLLVVVPSSVRFTWEQAFLRWLPSLSPDC 508
Cdd:cd18064 16 LRDYQVRGLNWLISlyeNGINGILADEMGLGKTLQTISLLGYmkhYRNiPGPHMVLVPKSTLHNWMAEFKRWVPTLRAVC 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 509 I-----NVVVTGKDRLTAGL--INIVSFDLLSKlEKQL--KTPFKVVIIDESHFLKNSRTaRCRAAMPVLKVAKRvILLS 579
Cdd:cd18064 96 LigdkdQRAAFVRDVLLPGEwdVCVTSYEMLIK-EKSVfkKFNWRYLVIDEAHRIKNEKS-KLSEIVREFKTTNR-LLLT 172
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 187761314 580 GTPAMSRPAELYTQIIAVKPTFFPQFHAFGlRYCDAKrmpwgwDYSGSSNLGELKLLLEEAVMLRRLKSDVLSQLPAKQ 658
Cdd:cd18064 173 GTPLQNNLHELWALLNFLLPDVFNSAEDFD-SWFDTN------NCLGDQKLVERLHMVLRPFLLRRIKADVEKSLPPKK 244
|
|
| DEXHc_CHD1L |
cd18006 |
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ... |
436-603 |
3.46e-14 |
|
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350764 [Multi-domain] Cd Length: 216 Bit Score: 72.47 E-value: 3.46e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 436 LMPFQRAGVNFAIAK---GGRLLLADDMGLGKTIQAICIAAFYRK----EWPLLVVVPSSVRFTWEQAFLRWLPSLSpdC 508
Cdd:cd18006 1 LRPYQLEGVNWLLQCraeQHGCILGDEMGLGKTCQTISLLWYLAGrlklLGPFLVLCPLSVLDNWKEELNRFAPDLS--V 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 509 INVVVTGKDR--LTAGLINIVSFD-LLSKLEKQLKT-------PFKVVIIDESHFLKNSRTArCRAAMPVLKVAKRvILL 578
Cdd:cd18006 79 ITYMGDKEKRldLQQDIKSTNRFHvLLTTYEICLKDasflksfPWASLVVDEAHRLKNQNSL-LHKTLSEFSVDFR-LLL 156
|
170 180
....*....|....*....|....*
gi 187761314 579 SGTPAMSRPAELYTQIIAVKPTFFP 603
Cdd:cd18006 157 TGTPIQNSLQELYALLSFIEPNVFP 181
|
|
| DEXQc_INO80 |
cd18002 |
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ... |
455-608 |
6.50e-13 |
|
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350760 [Multi-domain] Cd Length: 229 Bit Score: 69.07 E-value: 6.50e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 455 LLADDMGLGKTIQAICIAAFYRKE---W-PLLVVVPSSVRFTWEQAFLRWLPSLSpdCINVVVTGKDRLT---------- 520
Cdd:cd18002 23 ILADEMGLGKTVQSIAVLAHLAEEhniWgPFLVIAPASTLHNWQQEISRFVPQFK--VLPYWGNPKDRKVlrkfwdrknl 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 521 ----AGL-INIVSFDLLSKLEKQL-KTPFKVVIIDESHFLKNSRTARCRAAMPvLKVAKRvILLSGTPAMSRPAELYTQI 594
Cdd:cd18002 101 ytrdAPFhVVITSYQLVVQDEKYFqRVKWQYMVLDEAQAIKSSSSSRWKTLLS-FHCRNR-LLLTGTPIQNSMAELWALL 178
|
170
....*....|....
gi 187761314 595 IAVKPTFFPQFHAF 608
Cdd:cd18002 179 HFIMPTLFDSHDEF 192
|
|
| DEXHc_SMARCA1 |
cd18065 |
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ... |
427-602 |
1.16e-12 |
|
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350823 [Multi-domain] Cd Length: 233 Bit Score: 68.51 E-value: 1.16e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 427 EVDPKLVSN--LMPFQRAGVNFAIA---KGGRLLLADDMGLGKTIQAICIAAF---YRK-EWPLLVVVPSSVRFTWEQAF 497
Cdd:cd18065 5 EESPSYVKGgtLRDYQVRGLNWMISlyeNGVNGILADEMGLGKTLQTIALLGYlkhYRNiPGPHMVLVPKSTLHNWMNEF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 498 LRWLPSLSPDCInvvvTGKDRLTAGLIN-----------IVSFDLLSKlEKQLKTPF--KVVIIDESHFLKNSRTaRCRA 564
Cdd:cd18065 85 KRWVPSLRAVCL----IGDKDARAAFIRdvmmpgewdvcVTSYEMVIK-EKSVFKKFnwRYLVIDEAHRIKNEKS-KLSE 158
|
170 180 190
....*....|....*....|....*....|....*...
gi 187761314 565 AMPVLKVAKRvILLSGTPAMSRPAELYTQIIAVKPTFF 602
Cdd:cd18065 159 IVREFKTTNR-LLLTGTPLQNNLHELWALLNFLLPDVF 195
|
|
| DEXHc_SMARCA2 |
cd18063 |
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ... |
455-608 |
1.38e-12 |
|
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350821 [Multi-domain] Cd Length: 251 Bit Score: 68.55 E-value: 1.38e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 455 LLADDMGLGKTIQAICIAAFY----RKEWPLLVVVPSSVRFTWEQAFLRWLPSL-------SPDCINVVVTgkdRLTAGL 523
Cdd:cd18063 46 ILADEMGLGKTIQTIALITYLmehkRLNGPYLIIVPLSTLSNWTYEFDKWAPSVvkisykgTPAMRRSLVP---QLRSGK 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 524 INIV--SFDLLSKLEKQL-KTPFKVVIIDESHFLKNSRtARCRAAMPVLKVAKRVILLSGTPAMSRPAELYTQIIAVKPT 600
Cdd:cd18063 123 FNVLltTYEYIIKDKHILaKIRWKYMIVDEGHRMKNHH-CKLTQVLNTHYVAPRRILLTGTPLQNKLPELWALLNFLLPT 201
|
....*...
gi 187761314 601 FFPQFHAF 608
Cdd:cd18063 202 IFKSCSTF 209
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
436-820 |
1.63e-12 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 71.21 E-value: 1.63e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 436 LMPFQRAGVNFAIA----KGGRLLLADDMGLGKTIQAICIAAFYRKEWPLLVVVPS-SVRFTWEQAFLRWLPslspdciN 510
Cdd:COG1061 81 LRPYQQEALEALLAalerGGGRGLVVAPTGTGKTVLALALAAELLRGKRVLVLVPRrELLEQWAEELRRFLG-------D 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 511 VVVTGKDRLTAGLINIVSFDLLSKLE--KQLKTPFKVVIIDESHFLKNSRTARCRAAMPvlkvAKRVILLSGTP----AM 584
Cdd:COG1061 154 PLAGGGKKDSDAPITVATYQSLARRAhlDELGDRFGLVIIDEAHHAGAPSYRRILEAFP----AAYRLGLTATPfrsdGR 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 585 SRPAELYTQIIavkptffpqfhaFGLRYCDAkrmpwgwdysgssnlgelkllleeavmlrrLKSDVLSQlpakqrkivvi 664
Cdd:COG1061 230 EILLFLFDGIV------------YEYSLKEA------------------------------IEDGYLAP----------- 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 665 apgrinARTRAALDAAAKEMTTKDKTKQQQKDALIlffnRTAEAKIPSVIEYILDllESGREKFLVFAHHKVVLDAITQE 744
Cdd:COG1061 257 ------PEYYGIRVDLTDERAEYDALSERLREALA----ADAERKDKILRELLRE--HPDDRKTLVFCSSVDHAEALAEL 324
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 187761314 745 LERKHVQHIRIDGSTSSAEREDLCQQFqlSERHAVAVLSITAANMGLTFSSADLVVFAELFWNPGVLIQAEDRVHR 820
Cdd:COG1061 325 LNEAGIRAAVVTGDTPKKEREEILEAF--RDGELRILVTVDVLNEGVDVPRLDVAILLRPTGSPREFIQRLGRGLR 398
|
|
| DEXHc_RAD54A |
cd18067 |
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ... |
436-612 |
1.65e-12 |
|
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350825 [Multi-domain] Cd Length: 243 Bit Score: 68.27 E-value: 1.65e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 436 LMPFQRAGVNF--AIAKGGRL------LLADDMGLGKTIQaiCIAAFyrkeWPLL--------------VVVPSSVRFTW 493
Cdd:cd18067 1 LRPHQREGVKFlyRCVTGRRIrgshgcIMADEMGLGKTLQ--CITLM----WTLLrqspqckpeidkaiVVSPSSLVKNW 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 494 EQAFLRWL-PSLSPdcinVVVTGK-----DRLTAGLIN-----------IVSFDLL-SKLEKQLKTPFKVVIIDESHFLK 555
Cdd:cd18067 75 ANELGKWLgGRLQP----LAIDGGskkeiDRKLVQWASqqgrrvstpvlIISYETFrLHVEVLQKGEVGLVICDEGHRLK 150
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 187761314 556 NSRTaRCRAAMPVLKVAKRVIlLSGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRY 612
Cdd:cd18067 151 NSDN-QTYQALDSLNTQRRVL-LSGTPIQNDLSEYFSLVNFVNPGILGTAAEFKKNF 205
|
|
| DEXHc_CHD6 |
cd18058 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ... |
455-616 |
2.20e-12 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350816 [Multi-domain] Cd Length: 222 Bit Score: 67.37 E-value: 2.20e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 455 LLADDMGLGKTIQAICIAA--FYRK-EWPLLVVVPSSVRFTWEQAFLRWLPslspdcINVVVTGKDRLTAGLIN------ 525
Cdd:cd18058 23 ILADEMGLGKTIQSITFLSeiFLMGiRGPFLIIAPLSTITNWEREFRTWTE------MNAIVYHGSQISRQMIQqyemyy 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 526 -----------------IVSFDL-LSKLEKQLKTPFKVVIIDESHFLKNsRTARCRAAMPVLKVAKRViLLSGTPAMSRP 587
Cdd:cd18058 97 rdeqgnplsgifkfqvvITTFEMiLADCPELKKINWSCVIIDEAHRLKN-RNCKLLEGLKLMALEHKV-LLTGTPLQNSV 174
|
170 180
....*....|....*....|....*....
gi 187761314 588 AELYTQIIAVKPTFFPQFHAFGLRYCDAK 616
Cdd:cd18058 175 EELFSLLNFLEPSQFPSETTFLEEFGDLK 203
|
|
| DEXHc_CHD2 |
cd18054 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ... |
436-608 |
2.92e-12 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350812 [Multi-domain] Cd Length: 237 Bit Score: 67.34 E-value: 2.92e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 436 LMPFQRAGVNF---AIAKGGRLLLADDMGLGKTIQAICIAAF----YRKEWPLLVVVPSSVRFTWEQAFLRWLPSlspdc 508
Cdd:cd18054 21 LRDYQLEGLNWlahSWCKNNSVILADEMGLGKTIQTISFLSYlfhqHQLYGPFLLVVPLSTLTSWQREFEIWAPE----- 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 509 INVVVTGKDRLTAGLINivSFDLLSKLEKQLK-----TPFKVVI---------------IDESHFLKNSRTARCRAAMPV 568
Cdd:cd18054 96 INVVVYIGDLMSRNTIR--EYEWIHSQTKRLKfnaliTTYEILLkdktvlgsinwaflgVDEAHRLKNDDSLLYKTLIDF 173
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 187761314 569 LKVAKrvILLSGTPAMSRPAELYTQIIAVKPTFFPQFHAF 608
Cdd:cd18054 174 KSNHR--LLITGTPLQNSLKELWSLLHFIMPEKFEFWEDF 211
|
|
| DEXHc_SMARCA4 |
cd18062 |
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ... |
455-608 |
3.87e-12 |
|
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350820 [Multi-domain] Cd Length: 251 Bit Score: 67.38 E-value: 3.87e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 455 LLADDMGLGKTIQAICIAA----FYRKEWPLLVVVPSSVRFTWEQAFLRWLPSL-------SPDCINVVVTgkdRLTAGL 523
Cdd:cd18062 46 ILADEMGLGKTIQTIALITylmeHKRINGPFLIIVPLSTLSNWVYEFDKWAPSVvkvsykgSPAARRAFVP---QLRSGK 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 524 INIV--SFDLLSKLEKQL-KTPFKVVIIDESHFLKNSRtARCRAAMPVLKVAKRVILLSGTPAMSRPAELYTQIIAVKPT 600
Cdd:cd18062 123 FNVLltTYEYIIKDKQILaKIRWKYMIVDEGHRMKNHH-CKLTQVLNTHYVAPRRLLLTGTPLQNKLPELWALLNFLLPT 201
|
....*...
gi 187761314 601 FFPQFHAF 608
Cdd:cd18062 202 IFKSCSTF 209
|
|
| DEXHc_ERCC6 |
cd18000 |
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ... |
436-601 |
5.87e-12 |
|
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350758 [Multi-domain] Cd Length: 193 Bit Score: 65.42 E-value: 5.87e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 436 LMPFQRAGVNFAIAKGGRL---LLADDMGLGKTIQAIC--IAAFYRKEW--PLLVVVPSSVRFTWEQAFLRWLPSLspdc 508
Cdd:cd18000 1 LFKYQQTGVQWLWELHCQRvggILGDEMGLGKTIQIIAflAALHHSKLGlgPSLIVCPATVLKQWVKEFHRWWPPF---- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 509 iNVVV-------TGKDR---------------LTAGLINIVSFDLLSKLEKQL-KTPFKVVIIDESHFLKNSRtARCRAA 565
Cdd:cd18000 77 -RVVVlhssgsgTGSEEklgsierksqlirkvVGDGGILITTYEGFRKHKDLLlNHNWQYVILDEGHKIRNPD-AEITLA 154
|
170 180 190
....*....|....*....|....*....|....*.
gi 187761314 566 MPVLKVAKRVIlLSGTPAMSRPAELYTQIIAVKPTF 601
Cdd:cd18000 155 CKQLRTPHRLI-LSGTPIQNNLKELWSLFDFVFPPY 189
|
|
| DEXHc_CHD7 |
cd18059 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ... |
436-616 |
8.62e-12 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350817 [Multi-domain] Cd Length: 222 Bit Score: 65.82 E-value: 8.62e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 436 LMPFQRAGVN---FAIAKGGRLLLADDMGLGKTIQAIC-IAAFYRK--EWPLLVVVPSSVRFTWEQAFLRWLPslspdcI 509
Cdd:cd18059 1 LREYQLEGVNwllFNWYNTRNCILADEMGLGKTIQSITfLYEIYLKgiHGPFLVIAPLSTIPNWEREFRTWTE------L 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 510 NVVVTGKDRLTAGLIN-----------------------IVSFDL-LSKLEKQLKTPFKVVIIDESHFLKNsRTARCRAA 565
Cdd:cd18059 75 NVVVYHGSQASRRTIQlyemyfkdpqgrvikgsykfhaiITTFEMiLTDCPELRNIPWRCVVIDEAHRLKN-RNCKLLEG 153
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 187761314 566 MPVLKVAKRViLLSGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRYCDAK 616
Cdd:cd18059 154 LKMMDLEHKV-LLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQEFGDLK 203
|
|
| DEXHc_CHD8 |
cd18060 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ... |
436-616 |
1.13e-11 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350818 [Multi-domain] Cd Length: 222 Bit Score: 65.46 E-value: 1.13e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 436 LMPFQRAGVN---FAIAKGGRLLLADDMGLGKTIQAIC-IAAFYRK--EWPLLVVVPSSVRFTWEQAFLRWLPslspdcI 509
Cdd:cd18060 1 LREYQLEGVNwllFNWYNRQNCILADEMGLGKTIQSIAfLQEVYNVgiHGPFLVIAPLSTITNWEREFNTWTE------M 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 510 NVVV-------------------TGKDRLTAGLIN----IVSFDL-LSKLEKQLKTPFKVVIIDESHFLKNsRTARCRAA 565
Cdd:cd18060 75 NTIVyhgslasrqmiqqyemyckDSRGRLIPGAYKfdalITTFEMiLSDCPELREIEWRCVIIDEAHRLKN-RNCKLLDS 153
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 187761314 566 MPVLKVAKRViLLSGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRYCDAK 616
Cdd:cd18060 154 LKHMDLEHKV-LLTGTPLQNTVEELFSLLHFLEPSQFPSESEFLKDFGDLK 203
|
|
| DEXHc_CHD4 |
cd18056 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ... |
436-617 |
2.65e-11 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350814 [Multi-domain] Cd Length: 232 Bit Score: 64.70 E-value: 2.65e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 436 LMPFQRAGVN---FAIAKGGRLLLADDMGLGKTIQ-AICIAAFYRK---EWPLLVVVPSSVRFTWEQAFLRWLPSLSpdc 508
Cdd:cd18056 1 LHPYQLEGLNwlrFSWAQGTDTILADEMGLGKTVQtAVFLYSLYKEghsKGPFLVSAPLSTIINWEREFEMWAPDMY--- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 509 inVVVTGKDRLTAGLI--NIVSFD--------LLSKLEKQLKTPFKV----------------------VIIDESHFLKN 556
Cdd:cd18056 78 --VVTYVGDKDSRAIIreNEFSFEdnairggkKASRMKKEASVKFHVlltsyelitidmailgsidwacLIVDEAHRLKN 155
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 187761314 557 SRTARCRaampVLK--VAKRVILLSGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRYCDAKR 617
Cdd:cd18056 156 NQSKFFR----VLNgySLQHKLLLTGTPLQNNLEELFHLLNFLTPERFHNLEGFLEEFADIAK 214
|
|
| DEXHc_CHD5 |
cd18057 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ... |
436-617 |
3.11e-11 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350815 [Multi-domain] Cd Length: 232 Bit Score: 64.32 E-value: 3.11e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 436 LMPFQRAGVN---FAIAKGGRLLLADDMGLGKTIQAIC-IAAFYRK---EWPLLVVVPSSVRFTWEQAFLRWlpslSPDC 508
Cdd:cd18057 1 LHPYQLEGLNwlrFSWAQGTDTILADEMGLGKTVQTIVfLYSLYKEghsKGPYLVSAPLSTIINWEREFEMW----APDF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 509 INVVVTGkDRLTAGLI--NIVSFD--------LLSKLEKQLKTPFKV----------------------VIIDESHFLKN 556
Cdd:cd18057 77 YVVTYTG-DKESRSVIreNEFSFEdnairsgkKVFRMKKEAQIKFHVlltsyelitidqailgsiewacLVVDEAHRLKN 155
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 187761314 557 SRTARCRaAMPVLKVAKRvILLSGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRYCDAKR 617
Cdd:cd18057 156 NQSKFFR-VLNSYKIDYK-LLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADISK 214
|
|
| DEXHc_ATRX |
cd18068 |
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ... |
436-612 |
4.68e-10 |
|
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350826 [Multi-domain] Cd Length: 246 Bit Score: 61.06 E-value: 4.68e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 436 LMPFQRAGVNFAI------------AKGGRLLLADDMGLGKTIQAIC----------IAAFYRkewpLLVVVPSSVRFTW 493
Cdd:cd18068 1 LKPHQVDGVQFMWdccceslkktkkSPGSGCILAHCMGLGKTLQVVTflhtvllcekLENFSR----VLVVCPLNTVLNW 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 494 EQAFLRWLPSLS-PDCINV-----VVTGKDRLTA-------GLINIVSFDLLS--------KLEKQLKTPFK-------- 544
Cdd:cd18068 77 LNEFEKWQEGLKdEEKIEVnelatYKRPQERSYKlqrwqeeGGVMIIGYDMYRilaqernvKSREKLKEIFNkalvdpgp 156
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 187761314 545 -VVIIDESHFLKNSRTARCRAAMPVLkvAKRVILLSGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRY 612
Cdd:cd18068 157 dFVVCDEGHILKNEASAVSKAMNSIR--TKRRIVLTGTPLQNNLIEYHCMVNFVKPNLLGTIKEFRNRF 223
|
|
| DEXHc_CHD9 |
cd18061 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ... |
436-616 |
5.33e-10 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350819 [Multi-domain] Cd Length: 222 Bit Score: 60.40 E-value: 5.33e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 436 LMPFQRAGVN---FAIAKGGRLLLADDMGLGKTIQAIC-IAAFYRK--EWPLLVVVPSSVRFTWEQAFLRWLPslspdcI 509
Cdd:cd18061 1 LREYQLEGLNwllFNWYNRRNCILADEMGLGKTIQSITfLYEILLTgiRGPFLIIAPLSTIANWEREFRTWTD------L 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 510 NVVVTGKDRLTAGLIN-----------------------IVSFDLLSKLEKQLKT-PFKVVIIDESHFLKNsRTARCRAA 565
Cdd:cd18061 75 NVVVYHGSLISRQMIQqyemyfrdsqgriirgayrfqaiITTFEMILGGCPELNAiDWRCVIIDEAHRLKN-KNCKLLEG 153
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 187761314 566 MPVLKVAKRViLLSGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRYCDAK 616
Cdd:cd18061 154 LKLMNLEHKV-LLTGTPLQNTVEELFSLLHFLEPLRFPSESTFMQEFGDLK 203
|
|
| DEXHc_CHD3 |
cd18055 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ... |
439-617 |
6.75e-10 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350813 [Multi-domain] Cd Length: 232 Bit Score: 60.41 E-value: 6.75e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 439 FQRAGVN---FAIAKGGRLLLADDMGLGKTIQAICIAAFYRKE----WPLLVVVPSSVRFTWEQAFLRWlpslSPDCINV 511
Cdd:cd18055 4 YQLEGLNwlrFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEghtkGPFLVSAPLSTIINWEREFQMW----APDFYVV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 512 VVTG-KDRLTAGLINIVSFDLLS--------KLEKQLKTPFKV----------------------VIIDESHFLKNSRTA 560
Cdd:cd18055 80 TYTGdKDSRAIIRENEFSFDDNAvkggkkafKMKREAQVKFHVlltsyelvtidqaalgsirwacLVVDEAHRLKNNQSK 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 187761314 561 RCRaAMPVLKVAKRvILLSGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRYCDAKR 617
Cdd:cd18055 160 FFR-VLNGYKIDHK-LLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADISK 214
|
|
| DEXHc_HLTF1_SMARC3 |
cd18071 |
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ... |
451-592 |
6.10e-09 |
|
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350829 [Multi-domain] Cd Length: 239 Bit Score: 57.48 E-value: 6.10e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 451 GGrlLLADDMGLGKTIQAICIAAFYrkewPLLVVVPSSVRFTWEQAFLRwlpSLSPDCINVVVT-GKDR-LTAGLI---- 524
Cdd:cd18071 50 GG--ILADDMGLGKTLTTISLILAN----FTLIVCPLSVLSNWETQFEE---HVKPGQLKVYTYhGGERnRDPKLLskyd 120
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 187761314 525 ------NIVSFDLLSKLEKQLKT-PFKVVIIDESHFLKNSRTARCRAampVLKV-AKRVILLSGTPAMSRPAELYT 592
Cdd:cd18071 121 ivlttyNTLASDFGAKGDSPLHTiNWLRVVLDEGHQIRNPNAQQTKA---VLNLsSERRWVLTGTPIQNSPKDLGS 193
|
|
| DEXHc_CHD1 |
cd18053 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ... |
436-608 |
2.63e-08 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350811 [Multi-domain] Cd Length: 237 Bit Score: 55.83 E-value: 2.63e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 436 LMPFQRAGVNF---AIAKGGRLLLADDMGLGKTIQAICIAAFYRKEW----PLLVVVPSSVRFTWEQAFLRWLPSLspdc 508
Cdd:cd18053 21 LRDYQLNGLNWlahSWCKGNSCILADEMGLGKTIQTISFLNYLFHEHqlygPFLLVVPLSTLTSWQREIQTWAPQM---- 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 509 iNVVVTGKDRLTAGLINivSFDLLSKLEKQLK-----TPFKVVI---------------IDESHFLKNSRTARCRaAMPV 568
Cdd:cd18053 97 -NAVVYLGDINSRNMIR--THEWMHPQTKRLKfnillTTYEILLkdksflgglnwafigVDEAHRLKNDDSLLYK-TLID 172
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 187761314 569 LKVAKRvILLSGTPAMSRPAELYTQIIAVKPTFFPQFHAF 608
Cdd:cd18053 173 FKSNHR-LLITGTPLQNSLKELWSLLHFIMPEKFSSWEDF 211
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
436-582 |
4.05e-08 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 53.08 E-value: 4.05e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 436 LMPFQRAGVN--FAIAKGGRLLLADDMGLGKTIQAICIAAfYRKEWPLLVVVPS-SVRFTWEQAFLRWLPSLS------- 505
Cdd:cd17926 1 LRPYQEEALEawLAHKNNRRGILVLPTGSGKTLTALALIA-YLKELRTLIVVPTdALLDQWKERFEDFLGDSSigliggg 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 506 ----PDCINVVVTgkdrltagLINIVSFDLlsKLEKQLKTPFKVVIIDESHFLkNSRTARcraAMPVLKVAKRVILLSGT 581
Cdd:cd17926 80 kkkdFDDANVVVA--------TYQSLSNLA--EEEKDLFDQFGLLIVDEAHHL-PAKTFS---EILKELNAKYRLGLTAT 145
|
.
gi 187761314 582 P 582
Cdd:cd17926 146 P 146
|
|
| DEXHc_ARIP4 |
cd18069 |
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ... |
446-601 |
4.79e-07 |
|
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350827 [Multi-domain] Cd Length: 227 Bit Score: 51.74 E-value: 4.79e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 446 FAIAKGGRLLLADDMGLGKTIQAIC-IAAFYR--KEWPLLVVVPSSVRFTWEQAFLRWLPSLS------PDCINVVVTGK 516
Cdd:cd18069 23 YKGSSGFGCILAHSMGLGKTLQVISfLDVLLRhtGAKTVLAIVPVNTLQNWLSEFNKWLPPPEalpnvrPRPFKVFILND 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 517 DRLT----AGLIN---------IVSFDLLsklekQLKTPFKVVIIDESHFLKNSrTARCRAAMPVLKvAKRVILLSGTPA 583
Cdd:cd18069 103 EHKTtaarAKVIEdwvkdggvlLMGYEMF-----RLRPGPDVVICDEGHRIKNC-HASTSQALKNIR-SRRRIVLTGYPL 175
|
170
....*....|....*...
gi 187761314 584 MSRPAELYTQIIAVKPTF 601
Cdd:cd18069 176 QNNLIEYWCMVDFVRPDF 193
|
|
| DEXQc_SHPRH |
cd18070 |
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously ... |
436-528 |
5.18e-05 |
|
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously expressed protein that contains motifs characteristic of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 and is involved in DNA repair. SHPRH is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350828 [Multi-domain] Cd Length: 257 Bit Score: 45.80 E-value: 5.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 436 LMPFQRAGVNFAIAKGGrlLLADDMGLGKTIQAI-CIAAFYRKEWPLlvvvpssvrftwEQAFLRWLPSlspDCINVVVT 514
Cdd:cd18070 1 LLPYQRRAVNWMLVPGG--ILADEMGLGKTVEVLaLILLHPRPDNDL------------DAADDDSDEM---VCCPDCLV 63
|
90
....*....|....
gi 187761314 515 GKDRLTAGLINIVS 528
Cdd:cd18070 64 AETPVSSKATLIVC 77
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
451-581 |
1.65e-04 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 42.78 E-value: 1.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 451 GGRLLLADDMGLGKTIQA--ICIAAFYRKEWPLLVVVP-SSVRFTWEQAFLRWLPSLSPDCINV------VVTGKDRLTA 521
Cdd:cd00046 1 GENVLITAPTGSGKTLAAllAALLLLLKKGKKVLVLVPtKALALQTAERLRELFGPGIRVAVLVggssaeEREKNKLGDA 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 187761314 522 GLInIVS----FDLLSKLEKQLKTPFKVVIIDESH-FLKNSRTAR------CRAAMPVLkvakRVILLSGT 581
Cdd:cd00046 81 DII-IATpdmlLNLLLREDRLFLKDLKLIIVDEAHaLLIDSRGALildlavRKAGLKNA----QVILLSAT 146
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
461-552 |
3.33e-04 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 42.27 E-value: 3.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 461 GLGKTIQAICIAAFYRKEWPL---LVVVPS-SVRFTWEQAFLRWLPSLSPDCINVVVTGKDRLTAG----LINIVSFDLL 532
Cdd:pfam04851 33 GSGKTLTAAKLIARLFKKGPIkkvLFLVPRkDLLEQALEEFKKFLPNYVEIGEIISGDKKDESVDDnkivVTTIQSLYKA 112
|
90 100
....*....|....*....|..
gi 187761314 533 SKLEKQLKTP--FKVVIIDESH 552
Cdd:pfam04851 113 LELASLELLPdfFDVIIIDEAH 134
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
709-904 |
3.04e-03 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 41.40 E-value: 3.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 709 KIPSVIEYILD-LLESGREKFLVFAHHKVVLDAITQELERKHVQHIRIDGSTSSAEREDLCQQFQL-------SERHAVA 780
Cdd:PRK13766 348 KLEKLREIVKEqLGKNPDSRIIVFTQYRDTAEKIVDLLEKEGIKAVRFVGQASKDGDKGMSQKEQIeildkfrAGEFNVL 427
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 781 VlSITAANMGLTFSSADLVVFAElfwnPgvlIQAEDR-VHRIGQT--SSVG-IHYLVAKGTADD-YLWPLI------QEK 849
Cdd:PRK13766 428 V-STSVAEEGLDIPSVDLVIFYE----P---VPSEIRsIQRKGRTgrQEEGrVVVLIAKGTRDEaYYWSSRrkekkmKEE 499
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 187761314 850 IKVLAEAgLSETNFSEMTESTDYLYKDPKQQKIYDlFQKSFEKEGSDMELLEAAE 904
Cdd:PRK13766 500 LKNLKGI-LNKKLQELDEEQKGEEEEKDEQLSLDD-FVKSKGKEEEEEEEKEEKD 552
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
780-829 |
3.13e-03 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 37.30 E-value: 3.13e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 187761314 780 AVLSITAANMGLTFSSADLVVFAELFWNPGVLIQAEDRVHRIGQTSSVGI 829
Cdd:cd18785 25 ILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKDEGEVI 74
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
727-856 |
3.67e-03 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 40.91 E-value: 3.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187761314 727 KFLVFAHHKVVLDAITQELERKHVQHIRIDGSTSSAEREDLCQQFQlSERHAVAVLSITAANmGLTFSSADLVVFAELfw 806
Cdd:PTZ00110 379 KILIFVETKKGADFLTKELRLDGWPALCIHGDKKQEERTWVLNEFK-TGKSPIMIATDVASR-GLDVKDVKYVINFDF-- 454
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 187761314 807 nPGvliQAEDRVHRIGQTSSVGihylvAKGTADDYLWP----LIQEKIKVLAEA 856
Cdd:PTZ00110 455 -PN---QIEDYVHRIGRTGRAG-----AKGASYTFLTPdkyrLARDLVKVLREA 499
|
|
| |
