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Conserved domains on  [gi|189083851|ref|NP_001121077|]
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lysosomal acid lipase/cholesteryl ester hydrolase isoform 1 precursor [Homo sapiens]

Protein Classification

lipase family protein( domain architecture ID 706631)

lipase family protein that may function as a lipase, catalyzing the hydrolysis of ester bonds of insoluble substrates such a triglycerides

EC:  3.1.1.-
Gene Ontology:  GO:0016298|GO:0016788|GO:0006629

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
PLN02872 super family cl28691
triacylglycerol lipase
38-396 1.35e-54

triacylglycerol lipase


The actual alignment was detected with superfamily member PLN02872:

Pssm-ID: 215470 [Multi-domain]  Cd Length: 395  Bit Score: 185.46  E-value: 1.35e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189083851  38 SEIISYWGFPSEEYLVETEDGYILCLNRIPHGRKNHSDKgPKPVVFLQHGLLADSSNWVTNLANSSLGFILADAGFDVWM 117
Cdd:PLN02872  34 AQLIHPAGYSCTEHTIQTKDGYLLALQRVSSRNPRLGSQ-RGPPVLLQHGLFMAGDAWFLNSPEQSLGFILADHGFDVWV 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189083851 118 GNSRGNTWSRKHKTLSVSQDEFWAFSYDEMAKYDLPASINFILNKTgQEQVYYVGHSQGTTIGFIAFSQiPELAKRIKMF 197
Cdd:PLN02872 113 GNVRGTRWSYGHVTLSEKDKEFWDWSWQELALYDLAEMIHYVYSIT-NSKIFIVGHSQGTIMSLAALTQ-PNVVEMVEAA 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189083851 198 FALGPVASVAFCTSPMA-KLGRLP-DHLIKDLfGDKEFLPQSAFLKWLGTHVCT-HVILKELCGNLCFLLCGFNErnlnm 274
Cdd:PLN02872 191 ALLCPISYLDHVTAPLVlRMVFMHlDQMVVAM-GIHQLNFRSDVLVKLLDSICEgHMDCNDLLTSITGTNCCFNA----- 264
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189083851 275 SRVDVYTTHSPAGTSVQNMLHWSQAVKFQKFQAFDWGsSAKNYFHYNQSYPPTYNVKDMLVPTAVWS--GGHDWLADVYD 352
Cdd:PLN02872 265 SRIDYYLEYEPHPSSVKNLRHLFQMIRKGTFAHYDYG-IFKNLKLYGQVNPPAFDLSLIPKSLPLWMgyGGTDGLADVTD 343
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
gi 189083851 353 VNILLTQITN---LVFHESipeWEHLDFIWGLDAPWRLYNKIINLMR 396
Cdd:PLN02872 344 VEHTLAELPSkpeLLYLEN---YGHIDFLLSTSAKEDVYNHMIQFFR 387
 
Name Accession Description Interval E-value
PLN02872 PLN02872
triacylglycerol lipase
38-396 1.35e-54

triacylglycerol lipase


Pssm-ID: 215470 [Multi-domain]  Cd Length: 395  Bit Score: 185.46  E-value: 1.35e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189083851  38 SEIISYWGFPSEEYLVETEDGYILCLNRIPHGRKNHSDKgPKPVVFLQHGLLADSSNWVTNLANSSLGFILADAGFDVWM 117
Cdd:PLN02872  34 AQLIHPAGYSCTEHTIQTKDGYLLALQRVSSRNPRLGSQ-RGPPVLLQHGLFMAGDAWFLNSPEQSLGFILADHGFDVWV 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189083851 118 GNSRGNTWSRKHKTLSVSQDEFWAFSYDEMAKYDLPASINFILNKTgQEQVYYVGHSQGTTIGFIAFSQiPELAKRIKMF 197
Cdd:PLN02872 113 GNVRGTRWSYGHVTLSEKDKEFWDWSWQELALYDLAEMIHYVYSIT-NSKIFIVGHSQGTIMSLAALTQ-PNVVEMVEAA 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189083851 198 FALGPVASVAFCTSPMA-KLGRLP-DHLIKDLfGDKEFLPQSAFLKWLGTHVCT-HVILKELCGNLCFLLCGFNErnlnm 274
Cdd:PLN02872 191 ALLCPISYLDHVTAPLVlRMVFMHlDQMVVAM-GIHQLNFRSDVLVKLLDSICEgHMDCNDLLTSITGTNCCFNA----- 264
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189083851 275 SRVDVYTTHSPAGTSVQNMLHWSQAVKFQKFQAFDWGsSAKNYFHYNQSYPPTYNVKDMLVPTAVWS--GGHDWLADVYD 352
Cdd:PLN02872 265 SRIDYYLEYEPHPSSVKNLRHLFQMIRKGTFAHYDYG-IFKNLKLYGQVNPPAFDLSLIPKSLPLWMgyGGTDGLADVTD 343
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
gi 189083851 353 VNILLTQITN---LVFHESipeWEHLDFIWGLDAPWRLYNKIINLMR 396
Cdd:PLN02872 344 VEHTLAELPSkpeLLYLEN---YGHIDFLLSTSAKEDVYNHMIQFFR 387
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
80-380 3.71e-34

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 127.24  E-value: 3.71e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189083851   80 PVVFLQHGLLADSSNWvTNLANSslgfiLADAGFDVWMGNSRGNTWSRKHKTLsvsqdefwafsyDEMAKYDLPASINFI 159
Cdd:pfam00561   1 PPVLLLHGLPGSSDLW-RKLAPA-----LARDGFRVIALDLRGFGKSSRPKAQ------------DDYRTDDLAEDLEYI 62
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189083851  160 LNKTGQEQVYYVGHSQGTTIGFIAFSQIPElakRIKMFFALGPVasvafctSPMAKLGRLPDHLIKDLFGDKEFLPQSAF 239
Cdd:pfam00561  63 LEALGLEKVNLVGHSMGGLIALAYAAKYPD---RVKALVLLGAL-------DPPHELDEADRFILALFPGFFDGFVADFA 132
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189083851  240 LKWLGTHVCTHVILKELCGNLCFLLcgfNERNLNMSRVDVYTTHSPAGTSVQNMLHWSQAVKFQKFQAFDWgssaknyfh 319
Cdd:pfam00561 133 PNPLGRLVAKLLALLLLRLRLLKAL---PLLNKRFPSGDYALAKSLVTGALLFIETWSTELRAKFLGRLDE--------- 200
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 189083851  320 ynqsypptynvkdmlvPTAVWSGGHDWLADvYDVNILLTQITNLVFHESIPEWEHLDFIWG 380
Cdd:pfam00561 201 ----------------PTLIIWGDQDPLVP-PQALEKLAQLFPNARLVVIPDAGHFAFLEG 244
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
74-179 5.16e-07

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 47.90  E-value: 5.16e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189083851  74 SDKGPKPVVFLqHGLLADSSNWvTNLANSslgfiLADAGFDVWmgnsrgntwsrkhkTLSVSQDefwAFSYDEMAKYdLP 153
Cdd:COG1075    1 YAATRYPVVLV-HGLGGSAASW-APLAPR-----LRAAGYPVY--------------ALNYPST---NGSIEDSAEQ-LA 55
                         90       100
                 ....*....|....*....|....*.
gi 189083851 154 ASINFILNKTGQEQVYYVGHSQGTTI 179
Cdd:COG1075   56 AFVDAVLAATGAEKVDLVGHSMGGLV 81
 
Name Accession Description Interval E-value
PLN02872 PLN02872
triacylglycerol lipase
38-396 1.35e-54

triacylglycerol lipase


Pssm-ID: 215470 [Multi-domain]  Cd Length: 395  Bit Score: 185.46  E-value: 1.35e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189083851  38 SEIISYWGFPSEEYLVETEDGYILCLNRIPHGRKNHSDKgPKPVVFLQHGLLADSSNWVTNLANSSLGFILADAGFDVWM 117
Cdd:PLN02872  34 AQLIHPAGYSCTEHTIQTKDGYLLALQRVSSRNPRLGSQ-RGPPVLLQHGLFMAGDAWFLNSPEQSLGFILADHGFDVWV 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189083851 118 GNSRGNTWSRKHKTLSVSQDEFWAFSYDEMAKYDLPASINFILNKTgQEQVYYVGHSQGTTIGFIAFSQiPELAKRIKMF 197
Cdd:PLN02872 113 GNVRGTRWSYGHVTLSEKDKEFWDWSWQELALYDLAEMIHYVYSIT-NSKIFIVGHSQGTIMSLAALTQ-PNVVEMVEAA 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189083851 198 FALGPVASVAFCTSPMA-KLGRLP-DHLIKDLfGDKEFLPQSAFLKWLGTHVCT-HVILKELCGNLCFLLCGFNErnlnm 274
Cdd:PLN02872 191 ALLCPISYLDHVTAPLVlRMVFMHlDQMVVAM-GIHQLNFRSDVLVKLLDSICEgHMDCNDLLTSITGTNCCFNA----- 264
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189083851 275 SRVDVYTTHSPAGTSVQNMLHWSQAVKFQKFQAFDWGsSAKNYFHYNQSYPPTYNVKDMLVPTAVWS--GGHDWLADVYD 352
Cdd:PLN02872 265 SRIDYYLEYEPHPSSVKNLRHLFQMIRKGTFAHYDYG-IFKNLKLYGQVNPPAFDLSLIPKSLPLWMgyGGTDGLADVTD 343
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
gi 189083851 353 VNILLTQITN---LVFHESipeWEHLDFIWGLDAPWRLYNKIINLMR 396
Cdd:PLN02872 344 VEHTLAELPSkpeLLYLEN---YGHIDFLLSTSAKEDVYNHMIQFFR 387
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
80-380 3.71e-34

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 127.24  E-value: 3.71e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189083851   80 PVVFLQHGLLADSSNWvTNLANSslgfiLADAGFDVWMGNSRGNTWSRKHKTLsvsqdefwafsyDEMAKYDLPASINFI 159
Cdd:pfam00561   1 PPVLLLHGLPGSSDLW-RKLAPA-----LARDGFRVIALDLRGFGKSSRPKAQ------------DDYRTDDLAEDLEYI 62
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189083851  160 LNKTGQEQVYYVGHSQGTTIGFIAFSQIPElakRIKMFFALGPVasvafctSPMAKLGRLPDHLIKDLFGDKEFLPQSAF 239
Cdd:pfam00561  63 LEALGLEKVNLVGHSMGGLIALAYAAKYPD---RVKALVLLGAL-------DPPHELDEADRFILALFPGFFDGFVADFA 132
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189083851  240 LKWLGTHVCTHVILKELCGNLCFLLcgfNERNLNMSRVDVYTTHSPAGTSVQNMLHWSQAVKFQKFQAFDWgssaknyfh 319
Cdd:pfam00561 133 PNPLGRLVAKLLALLLLRLRLLKAL---PLLNKRFPSGDYALAKSLVTGALLFIETWSTELRAKFLGRLDE--------- 200
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 189083851  320 ynqsypptynvkdmlvPTAVWSGGHDWLADvYDVNILLTQITNLVFHESIPEWEHLDFIWG 380
Cdd:pfam00561 201 ----------------PTLIIWGDQDPLVP-PQALEKLAQLFPNARLVVIPDAGHFAFLEG 244
Abhydro_lipase pfam04083
Partial alpha/beta-hydrolase lipase region; This family corresponds to a N-terminal part of an ...
37-99 8.09e-33

Partial alpha/beta-hydrolase lipase region; This family corresponds to a N-terminal part of an alpha/beta hydrolase domain.


Pssm-ID: 461162 [Multi-domain]  Cd Length: 63  Bit Score: 117.64  E-value: 8.09e-33
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 189083851   37 VSEIISYWGFPSEEYLVETEDGYILCLNRIPHGRKNHSDKGPKPVVFLQHGLLADSSNWVTNL 99
Cdd:pfam04083   1 VSEIIRYYGYPVEEHEVTTEDGYILTLHRIPAGRNNSNGKGGKPVVLLQHGLLASSDNWVTNG 63
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
74-179 5.16e-07

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 47.90  E-value: 5.16e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189083851  74 SDKGPKPVVFLqHGLLADSSNWvTNLANSslgfiLADAGFDVWmgnsrgntwsrkhkTLSVSQDefwAFSYDEMAKYdLP 153
Cdd:COG1075    1 YAATRYPVVLV-HGLGGSAASW-APLAPR-----LRAAGYPVY--------------ALNYPST---NGSIEDSAEQ-LA 55
                         90       100
                 ....*....|....*....|....*.
gi 189083851 154 ASINFILNKTGQEQVYYVGHSQGTTI 179
Cdd:COG1075   56 AFVDAVLAATGAEKVDLVGHSMGGLV 81
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
47-194 1.51e-06

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 48.84  E-value: 1.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189083851  47 PSEEYLVETEDGYILclnripHGRKNHSDKGPKPVVFLQHGlLADSSNWVTNLANSslgfiLADAGFDVWMGNSRGNTWS 126
Cdd:COG2267    2 TRRLVTLPTRDGLRL------RGRRWRPAGSPRGTVVLVHG-LGEHSGRYAELAEA-----LAAAGYAVLAFDLRGHGRS 69
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 189083851 127 RKHKTLSVsqdefwafSYDEMAKyDLPASINFILNKTGQeQVYYVGHSQGTTIGFIAFSQIPELAKRI 194
Cdd:COG2267   70 DGPRGHVD--------SFDDYVD-DLRAALDALRARPGL-PVVLLGHSMGGLIALLYAARYPDRVAGL 127
COG4757 COG4757
Predicted alpha/beta hydrolase [General function prediction only];
47-194 7.05e-04

Predicted alpha/beta hydrolase [General function prediction only];


Pssm-ID: 443790 [Multi-domain]  Cd Length: 289  Bit Score: 41.02  E-value: 7.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189083851  47 PSEEYLVETEDGYILCLNRIPHgrknhsDKGPKPVVFLqHGLLADSSNWVTNLANSslgfiLADAGFDVW------MGNS 120
Cdd:COG4757    6 SPESVTITAADGYPLAARLFPP------AGPPRAVVLI-NPATGVPQRFYRPFARY-----LAERGFAVLtydyrgIGLS 73
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 189083851 121 RgNTWSRKHKtlsvsqdefwaFSYDEMAKYDLPASINFILNKTGQEQVYYVGHSQGttiGFIA-FSQIPELAKRI 194
Cdd:COG4757   74 R-PGSLRGFD-----------AGYRDWGELDLPAVLDALRARFPGLPLLLVGHSLG---GQLLgLAPNAERVDRL 133
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
75-205 1.73e-03

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 39.61  E-value: 1.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189083851  75 DKGPKPVVFLQHGLLADSSNWVTNLANsslgfILADAGFDVWMGNSRGNTWSRKHktlsvsqdefwaFSYDEMAkyDLPA 154
Cdd:COG1506   19 DGKKYPVVVYVHGGPGSRDDSFLPLAQ-----ALASRGYAVLAPDYRGYGESAGD------------WGGDEVD--DVLA 79
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 189083851 155 SINFILNKTG--QEQVYYVGHSQGttiGFIAFSQIPELAKRIKMFFALGPVAS 205
Cdd:COG1506   80 AIDYLAARPYvdPDRIGIYGHSYG---GYMALLAAARHPDRFKAAVALAGVSD 129
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
78-185 5.87e-03

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 37.96  E-value: 5.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189083851   78 PKPVVFLQHGLlADSSNWVTNLANSslgfiLADAGFDVWMGNSRGntwsrkHKtLSVSQDEFWAfSYDEMAKyDLPASIN 157
Cdd:pfam12146   3 PRAVVVLVHGL-GEHSGRYAHLADA-----LAAQGFAVYAYDHRG------HG-RSDGKRGHVP-SFDDYVD-DLDTFVD 67
                          90       100
                  ....*....|....*....|....*...
gi 189083851  158 FILNKTGQEQVYYVGHSQGttiGFIAFS 185
Cdd:pfam12146  68 KIREEHPGLPLFLLGHSMG---GLIAAL 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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