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Conserved domains on  [gi|293651611|ref|NP_001121621|]
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ataxin-7 isoform c [Homo sapiens]

Protein Classification

SCA7 domain-containing protein( domain architecture ID 10550843)

SCA7 domain-containing protein similar to protein Sgf73/Sca7 which is a component of the multihistone acetyltransferase complexes SAGA and SILK

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SCA7 pfam08313
SCA7, zinc-binding domain; This domain is found in the protein Sgf73/Sca7 which is a component ...
 188-249 4.55e-27

SCA7, zinc-binding domain; This domain is found in the protein Sgf73/Sca7 which is a component of the multihistone acetyltransferase complexes SAGA and SILK. This domain is also found in Ataxin-7, a human protein which in its polyglutamine expanded pathological form, is responsible for the neurodegenerative disease spinocerebellar ataxia 7 (SCA7). Ataxin-7 is an integral component of the mammalian SAGA-like complexes, the TATA-binding protein-free TAF-containing complex (TFTC) and the SPT3/TAF9/GCN5 acetyltransferase complex (STAGA). This domain is a minimal domain in ataxin-7-like proteins that is required for interaction with TFTC/STAGA subunits and is conserved highly through evolution. The domain contains a conserved Cys(3)His motif that binds zinc, thus indicating this to be a new zinc-binding domain.


:

Pssm-ID: 462422  Cd Length: 61  Bit Score: 104.22  E-value: 4.55e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 293651611  188 NKRLSEREFDPDIHCGVIdLDTKKPCTRSLTCKTHSLTQRRAVQGRRKRFDVLLAEHKNKTR 249
Cdd:pfam08313   1 KKPKAKRPVDVDKQCGVI-LPNGGPCTRSLTCKTHSMGAKRAVPGRSKPFDVLLAEYQKKNQ 61
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 258-343 3.09e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 3.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 293651611  258 DSQQPPQPLRDPHPAPPRTSQEPHQNPHGVIPSESKPfvaskPKPHTPSLPRPPGCPAQQGGSAPIDPPPVHESPHPPLP 337
Cdd:PHA03247 2697 SLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASP-----ALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAP 2771


                  ....*.
gi 293651611  338 ATEPAS 343
Cdd:PHA03247 2772 PAAPAA 2777
 
Name Accession Description Interval E-value
SCA7 pfam08313
SCA7, zinc-binding domain; This domain is found in the protein Sgf73/Sca7 which is a component ...
 188-249 4.55e-27

SCA7, zinc-binding domain; This domain is found in the protein Sgf73/Sca7 which is a component of the multihistone acetyltransferase complexes SAGA and SILK. This domain is also found in Ataxin-7, a human protein which in its polyglutamine expanded pathological form, is responsible for the neurodegenerative disease spinocerebellar ataxia 7 (SCA7). Ataxin-7 is an integral component of the mammalian SAGA-like complexes, the TATA-binding protein-free TAF-containing complex (TFTC) and the SPT3/TAF9/GCN5 acetyltransferase complex (STAGA). This domain is a minimal domain in ataxin-7-like proteins that is required for interaction with TFTC/STAGA subunits and is conserved highly through evolution. The domain contains a conserved Cys(3)His motif that binds zinc, thus indicating this to be a new zinc-binding domain.


Pssm-ID: 462422  Cd Length: 61  Bit Score: 104.22  E-value: 4.55e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 293651611  188 NKRLSEREFDPDIHCGVIdLDTKKPCTRSLTCKTHSLTQRRAVQGRRKRFDVLLAEHKNKTR 249
Cdd:pfam08313   1 KKPKAKRPVDVDKQCGVI-LPNGGPCTRSLTCKTHSMGAKRAVPGRSKPFDVLLAEYQKKNQ 61
PHA03247 PHA03247
large tegument protein UL36; Provisional
 258-343 3.09e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 3.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 293651611  258 DSQQPPQPLRDPHPAPPRTSQEPHQNPHGVIPSESKPfvaskPKPHTPSLPRPPGCPAQQGGSAPIDPPPVHESPHPPLP 337
Cdd:PHA03247 2697 SLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASP-----ALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAP 2771


                  ....*.
gi 293651611  338 ATEPAS 343
Cdd:PHA03247 2772 PAAPAA 2777
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 257-337 2.81e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 41.29  E-value: 2.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 293651611  257 PDSQQPPQPLRDPHPAPPRTSQEPHQNPHGVIPSESKPFVASKPKPHTPSLPRPPGCPAQQGGSAPIdPPPVHESPHPPL 336
Cdd:pfam03154 200 TPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPL-PQPSLHGQMPPM 278


                  .
gi 293651611  337 P 337
Cdd:pfam03154 279 P 279
 
Name Accession Description Interval E-value
SCA7 pfam08313
SCA7, zinc-binding domain; This domain is found in the protein Sgf73/Sca7 which is a component ...
 188-249 4.55e-27

SCA7, zinc-binding domain; This domain is found in the protein Sgf73/Sca7 which is a component of the multihistone acetyltransferase complexes SAGA and SILK. This domain is also found in Ataxin-7, a human protein which in its polyglutamine expanded pathological form, is responsible for the neurodegenerative disease spinocerebellar ataxia 7 (SCA7). Ataxin-7 is an integral component of the mammalian SAGA-like complexes, the TATA-binding protein-free TAF-containing complex (TFTC) and the SPT3/TAF9/GCN5 acetyltransferase complex (STAGA). This domain is a minimal domain in ataxin-7-like proteins that is required for interaction with TFTC/STAGA subunits and is conserved highly through evolution. The domain contains a conserved Cys(3)His motif that binds zinc, thus indicating this to be a new zinc-binding domain.


Pssm-ID: 462422  Cd Length: 61  Bit Score: 104.22  E-value: 4.55e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 293651611  188 NKRLSEREFDPDIHCGVIdLDTKKPCTRSLTCKTHSLTQRRAVQGRRKRFDVLLAEHKNKTR 249
Cdd:pfam08313   1 KKPKAKRPVDVDKQCGVI-LPNGGPCTRSLTCKTHSMGAKRAVPGRSKPFDVLLAEYQKKNQ 61
PHA03247 PHA03247
large tegument protein UL36; Provisional
 258-343 3.09e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 3.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 293651611  258 DSQQPPQPLRDPHPAPPRTSQEPHQNPHGVIPSESKPfvaskPKPHTPSLPRPPGCPAQQGGSAPIDPPPVHESPHPPLP 337
Cdd:PHA03247 2697 SLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASP-----ALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAP 2771


                  ....*.
gi 293651611  338 ATEPAS 343
Cdd:PHA03247 2772 PAAPAA 2777
PHA03247 PHA03247
large tegument protein UL36; Provisional
 262-521 1.10e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 1.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 293651611  262 PPQPLRDPHPAPPRTSQEPHQNPHGVIPS----ESKPFVAskPKPHTPSLPR-PPGCPAqqGGSAPIDPPPVHESPHPPL 336
Cdd:PHA03247 2553 PPLPPAAPPAAPDRSVPPPRPAPRPSEPAvtsrARRPDAP--PQSARPRAPVdDRGDPR--GPAPPSPLPPDTHAPDPPP 2628

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 293651611  337 PatEPASRLSSEEGEGDDKEESVEKLDCHYSGHHPQPASFCTFGSRQIGRGYYVFDSRWNRLRCALNLMVEkhlnaqlWK 416
Cdd:PHA03247 2629 P--SPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTS-------LA 2699

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 293651611  417 KIPPVPSTTSPISTRIPHRTNSVPTSQCGVSYLAAATVSTSPVLLSSTCISPNSKSVPAHGTTLNAQPAASGAMDPVCSM 496
Cdd:PHA03247 2700 DPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGP 2779

                         250       260
                  ....*....|....*....|....*
gi 293651611  497 QSRQVSSSSSSPSTPSGLSSVPSSP 521
Cdd:PHA03247 2780 PRRLTRPAVASLSESRESLPSPWDP 2804
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 257-337 2.81e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 41.29  E-value: 2.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 293651611  257 PDSQQPPQPLRDPHPAPPRTSQEPHQNPHGVIPSESKPFVASKPKPHTPSLPRPPGCPAQQGGSAPIdPPPVHESPHPPL 336
Cdd:pfam03154 200 TPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPL-PQPSLHGQMPPM 278


                  .
gi 293651611  337 P 337
Cdd:pfam03154 279 P 279
PHA03247 PHA03247
large tegument protein UL36; Provisional
 257-341 5.09e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 5.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 293651611  257 PDSQQPPQPLRDPHPAPPRTSQEPHQNPHGVIPSESKPfvaSKPKPHTPSLPRPPGCPAQQGGSAPIdPPPVHESPHPPL 336
Cdd:PHA03247 2889 PAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPP---PQPQPPPPPPPRPQPPLAPTTDPAGA-GEPSGAVPQPWL 2964


                  ....*
gi 293651611  337 PATEP 341
Cdd:PHA03247 2965 GALVP 2969
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 260-344 6.98e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.97  E-value: 6.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 293651611 260 QQPPQPLRDPHPAPPRTSQEPHQNPHGVIPSESKPFVASKPKPHTPSLPRPPGCPAQQGGSAPIDPPPVHESPHPPLPAT 339
Cdd:PRK07764 616 AAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAG 695


                 ....*
gi 293651611 340 EPASR 344
Cdd:PRK07764 696 AAPAQ 700
PHA03247 PHA03247
large tegument protein UL36; Provisional
 255-346 9.13e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.54  E-value: 9.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 293651611  255 RHPDSQQPPQPLRDPHPAPPRTSQEPHQNPHGVIPSESKPfVASKPKPHTPSLPRPPGCPAQQGGSAP-IDPPPVHESPH 333
Cdd:PHA03247 2865 RPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQ-PERPPQPQAPPPPQPQPQPPPPPQPQPpPPPPPRPQPPL 2943

                          90
                  ....*....|...
gi 293651611  334 PPLPATEPASRLS 346
Cdd:PHA03247 2944 APTTDPAGAGEPS 2956
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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