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Conserved domains on  [gi|190341022|ref|NP_001121781|]
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tetraspanin-14 isoform 2 precursor [Homo sapiens]

Protein Classification

tetraspanin family protein( domain architecture ID 548)

tetraspanin family protein is a transmembrane (TM) glycoprotein with four TM segments that facilitates the interaction of membrane and intracellular signaling molecules (such as integrins, pro-growth factors and their receptors, protein kinase-C) in the formation of membrane signaling microdomains (also referred to as the tetraspanin web)

Gene Ontology:  GO:0005886|GO:0097197
PubMed:  15763890|11756464|19709882|16024509
SCOP:  4001512

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
tetraspanin_LEL super family cl02781
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 23-110 9.36e-53

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


The actual alignment was detected with superfamily member cd03159:

Pssm-ID: 351888 [Multi-domain]  Cd Length: 121  Bit Score: 162.98  E-value: 9.36e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190341022  23 NIIF----WNQCCGAYGPEDWDLNVYFNCSGASYSREKCGVPFSCCVPDPAQKVVNTQCGYDVRIQLKSKWDESIFTKGC 98
Cdd:cd03159   30 NLIDflqeYWQCCGARGPDDWNLNIYFNCTDSNPSRERCGVPFSCCVKDPAEDVVNTQCGYDVRKKPELELQHHIHTKGC 109

                         90
                 ....*....|..
gi 190341022  99 IQALESWLPRNI 110
Cdd:cd03159  110 VQAFEKWLQDNL 121
Tetraspanin super family cl28961
Tetraspanin family;
96-135 3.85e-04

Tetraspanin family;


The actual alignment was detected with superfamily member pfam00335:

Pssm-ID: 459767  Cd Length: 183  Bit Score: 38.84  E-value: 3.85e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 190341022   96 KGCIQALESWLPRNIYIVAGVFIAISLLQIFGIFLARTLI 135
Cdd:pfam00335 143 GGCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCLC 182
 
Name Accession Description Interval E-value
TM4SF9_like_LEL cd03159
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. ...
 23-110 9.36e-53

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 9 (TM4SF9) or Tetraspanin-5 and related proteins. TM4SF9 is strongly expressed witin the central nervous system, and expression levels appear to correlate with differentiation status of particular neurons, hinting at a role in neuronal maturation.


Pssm-ID: 239412 [Multi-domain]  Cd Length: 121  Bit Score: 162.98  E-value: 9.36e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190341022  23 NIIF----WNQCCGAYGPEDWDLNVYFNCSGASYSREKCGVPFSCCVPDPAQKVVNTQCGYDVRIQLKSKWDESIFTKGC 98
Cdd:cd03159   30 NLIDflqeYWQCCGARGPDDWNLNIYFNCTDSNPSRERCGVPFSCCVKDPAEDVVNTQCGYDVRKKPELELQHHIHTKGC 109

                         90
                 ....*....|..
gi 190341022  99 IQALESWLPRNI 110
Cdd:cd03159  110 VQAFEKWLQDNL 121
Tetraspanin pfam00335
Tetraspanin family;
96-135 3.85e-04

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 38.84  E-value: 3.85e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 190341022   96 KGCIQALESWLPRNIYIVAGVFIAISLLQIFGIFLARTLI 135
Cdd:pfam00335 143 GGCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCLC 182
 
Name Accession Description Interval E-value
TM4SF9_like_LEL cd03159
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. ...
 23-110 9.36e-53

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 9 (TM4SF9) or Tetraspanin-5 and related proteins. TM4SF9 is strongly expressed witin the central nervous system, and expression levels appear to correlate with differentiation status of particular neurons, hinting at a role in neuronal maturation.


Pssm-ID: 239412 [Multi-domain]  Cd Length: 121  Bit Score: 162.98  E-value: 9.36e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190341022  23 NIIF----WNQCCGAYGPEDWDLNVYFNCSGASYSREKCGVPFSCCVPDPAQKVVNTQCGYDVRIQLKSKWDESIFTKGC 98
Cdd:cd03159   30 NLIDflqeYWQCCGARGPDDWNLNIYFNCTDSNPSRERCGVPFSCCVKDPAEDVVNTQCGYDVRKKPELELQHHIHTKGC 109

                         90
                 ....*....|..
gi 190341022  99 IQALESWLPRNI 110
Cdd:cd03159  110 VQAFEKWLQDNL 121
penumbra_like_LEL cd03158
Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. ...
 29-110 5.14e-24

Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Human Penumbra exhibits growth-suppressive activity in vitro and has been associated with myeloid malignancies.


Pssm-ID: 239411  Cd Length: 119  Bit Score: 89.67  E-value: 5.14e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190341022  29 QCCGAYGPEDWDLNVYFNCSgaSYSREKCGVPFSCCVPDPAQKVVNTQCGYDVRIQLKSKWDESIFTKGCIQALESWLPR 108
Cdd:cd03158   40 KCCGGDDYRDWSKNMYFNCS--SPNPEACGVPYSCCIRAKDQEVINTMCGYGVQNLERLEASKLIYTRGCIDAVVLWIED 117


                 ..
gi 190341022 109 NI 110
Cdd:cd03158  118 NL 119
oculospanin_like_LEL cd03167
Tetraspanin, extracellular domain or large extracellular loop (LEL), oculospanin_like family. ...
 29-110 8.39e-15

Tetraspanin, extracellular domain or large extracellular loop (LEL), oculospanin_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contains sequences similar to oculospanin, which is found to be expressed in retinal pigment epithelium, iris, ciliary body, and retinal ganglion cells.


Pssm-ID: 239420  Cd Length: 120  Bit Score: 65.95  E-value: 8.39e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190341022  29 QCCGAYGPEDWDLNVYFNCSGASYSreKCGVPFSCCVPDP-AQKVVNTQCGYDVrIQLKSKWDES-IFTKGCIQALESWL 106
Cdd:cd03167   40 QCCGASSYQDWQQNLYFNCSSPGVQ--ACSLPASCCIDPReDGAVVNDQCGFGA-LGLDEDAAQRvVHLGGCGPPLRRWL 116


                 ....
gi 190341022 107 PRNI 110
Cdd:cd03167  117 RGNL 120
CD151_like_LEL cd03155
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. ...
 29-110 7.47e-07

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD151strongly associates with integrins, especially alpha3beta1, alpha6beta1, alpha7beta1, and alpha6beta4; it may play roles in cell-cell adhesion, cell migration, platelet aggregation, and angiogenesis. For example, CD151 is is involved in regulation of migration of neutrophils, endothelial cells, and various tumor cell lines; it associates specifically with laminin-binding integrins and strengthens alpha6beta1 integrin-mediated adhesion to laminin-1; CD151 also specifically attenuates adhesion-dependent activation of Ras and correspdonding downstream effects, and is involved in epithelial cell-cell adhesion as a modulator of PKC- and Cdc42-dependent actin cytoskeletal reorganization.


Pssm-ID: 239408 [Multi-domain]  Cd Length: 110  Bit Score: 45.03  E-value: 7.47e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190341022  29 QCCGAYGPEDWDLNVYFNCSGASYSRekcgVPFSCCVP----DPAQKVVNTQCGYdvriqlkskwdesiFTKGCIQALES 104
Cdd:cd03155   43 KCCGSNNYTDWQDSEWINSNEANGRL----VPDSCCKTvvdrCGCLRDHPSNIYK--------------VEGGCIPKLED 104


                 ....*.
gi 190341022 105 WLPRNI 110
Cdd:cd03155  105 FLYDHL 110
uroplakin_I_like_LEL cd03156
Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. ...
 26-110 9.37e-07

Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Uroplakin Ia and Ib are components of the 16nm protein particles, which are packed hexagonally to form 2D crystals of asymmetric unit membranes, and cover the apical surface of mammalian urothelium, contributing to the urinay bladder's permeability barrier function. Uroplakins Ia and Ib are maturation facilitators. They trigger conformational changes in their single-transmembrane-domain binding partner proteins uroplakin II and IIIa, which in turn may lead to ER-exit, stabilization, and cell-surface expression.


Pssm-ID: 239409  Cd Length: 114  Bit Score: 44.83  E-value: 9.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190341022  26 FWN------QCCGAYGPEDW-DLNVYFNCSGASYSRekcgVPFSCCVPDPAQKVVNTQCGydvriqlKSKWDESIFTKGC 98
Cdd:cd03156   34 TWNrvmielKCCGVNGPTDFvDSTSFFRQKNEPNSP----YPESCCKRNSNSQIVDLDCP-------KLGSPNSYNKKGC 102

                         90
                 ....*....|..
gi 190341022  99 IQALESWLPRNI 110
Cdd:cd03156  103 YEKLSNPIERYA 114
tetraspanin_LEL cd03127
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 29-106 1.07e-06

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


Pssm-ID: 239401 [Multi-domain]  Cd Length: 90  Bit Score: 44.03  E-value: 1.07e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 190341022  29 QCCGAYGPEDWDLNVyfncsgasysrekCGVPFSCCVPDPAQKVVNtqcgydvriqlkskwdesIFTKGCIQALESWL 106
Cdd:cd03127   40 ECCGVNGPTDYLDLR-------------LLVPSSCCKGTDGNCGLN------------------LYTEGCLEKLVDFL 86
CD37_CD82_like_LEL cd03160
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. ...
 29-110 2.09e-06

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD37 is a leukocyte-specific protein, and its restricted expression pattern suggests a role in the immune system. A regulatory role in T-cell proliferation has been suggested. CD82 is a metastasis suppressor implicated in biological processes ranging from fusion, adhesion, and migration to apoptosis and alterations of cell morphology.


Pssm-ID: 239413  Cd Length: 117  Bit Score: 43.91  E-value: 2.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190341022  29 QCCGAYGPEDWDLNVyfncsgASYSREKCGVPFSCCV---PDPAQKVVNTQCgydvriQLKSKWDESIFTKGCIQALESW 105
Cdd:cd03160   44 QCCGWTGPQDWTDNS------LIKNSSEPLYPCSCCNssaTADSPRPSKGFC------EAPASLDWPVYQEGCMEKLQSW 111


                 ....*
gi 190341022 106 LPRNI 110
Cdd:cd03160  112 LNENL 116
Tetraspanin pfam00335
Tetraspanin family;
96-135 3.85e-04

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 38.84  E-value: 3.85e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 190341022   96 KGCIQALESWLPRNIYIVAGVFIAISLLQIFGIFLARTLI 135
Cdd:pfam00335 143 GGCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCLC 182
CD63_LEL cd03166
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins ...
 28-110 6.24e-04

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD63 is present in platelets, neutrophils, and endothelial cells, amongst others. In platelets it associates with the integrin alphaIIBbeta3 and may modulate alphaIIbbeta3-dependent cytoskeletal reorganization.


Pssm-ID: 239419  Cd Length: 99  Bit Score: 37.07  E-value: 6.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190341022  28 NQCCGAYGPEDWDlnvyfNCSGASYSRekcgVPFSCCvpdpaqKVVNTQCGYDVRIQlkskwdeSIFTKGCIQALESWLP 107
Cdd:cd03166   39 LKCCGANNYTDWE-----NIPSLDTDS----VPDSCC------INVTKGCGINFDEK-------VIHLEGCVTKIEGWLK 96


                 ...
gi 190341022 108 RNI 110
Cdd:cd03166   97 KNI 99
peripherin_like_LEL cd03162
Tetraspanin, extracellular domain or large extracellular loop (LEL), peripherin_like family. ...
 1-106 4.68e-03

Tetraspanin, extracellular domain or large extracellular loop (LEL), peripherin_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Peripherin, or RDS (retinal degradation slow) is a glycoprotein expressed in vertebrate photoreceptors, located at the rim of the disc membranes of the photoreceptor outer segments. RDS is thought to play a major role in folding and stacking of the discs. Mutations in RDS have been linked to hereditary retinal dystrophies, which typically exhibit a wide phenotypic spectrum.


Pssm-ID: 239415  Cd Length: 143  Bit Score: 35.10  E-value: 4.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190341022   1 MHYYRYSNAKVSCWYKYLLFSYNIIFwnQCCGAYGPEDW-----DLNVYFNCSgasySREKC--------------GVPF 61
Cdd:cd03162   19 MKFYKDTDTPGRCFLKKTIDMLQIEF--QCCGNNGYRDWfeiqwISNRYLDFS----SKEVKdriksnvdgryltdGVPF 92

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 190341022  62 SCCVPDPAQKVVNTQC--GYDVRIQLKSKWDESIFTKGCIQALESWL 106
Cdd:cd03162   93 SCCNPSSPRPCIQHQItdNSAHYNYDYQTEELNLWTRGCREALLEYY 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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