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Conserved domains on  [gi|193788651|ref|NP_001123362|]
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leucine-rich repeat-containing protein 69 isoform 1 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
5-233 2.35e-23

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.01  E-value: 2.35e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788651   5 LLIKALSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNlipkvcPELCNLTQLTTLNLGNNLLEEVPEEMKYLTS 84
Cdd:COG4886   64 SLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------EELSNLTNLESLDLSGNQLTDLPEELANLTN 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788651  85 LKNLHLSGNRIcrfapgacdglqnlillnlnnnhlTQLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQ 164
Cdd:COG4886  138 LKELDLSNNQL------------------------TDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQ 193

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 193788651 165 LICIPEEIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDLKLREFYCEGNPL 233
Cdd:COG4886  194 ITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQL 262
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
5-233 2.35e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.01  E-value: 2.35e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788651   5 LLIKALSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNlipkvcPELCNLTQLTTLNLGNNLLEEVPEEMKYLTS 84
Cdd:COG4886   64 SLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------EELSNLTNLESLDLSGNQLTDLPEELANLTN 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788651  85 LKNLHLSGNRIcrfapgacdglqnlillnlnnnhlTQLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQ 164
Cdd:COG4886  138 LKELDLSNNQL------------------------TDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQ 193

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 193788651 165 LICIPEEIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDLKLREFYCEGNPL 233
Cdd:COG4886  194 ITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQL 262
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 19-211 1.99e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.10  E-value: 1.99e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788651  19 ITLNGKKMTKMPsALGKLPGLKTLVLQNNLIPKVcPELCNLTQLTTLNLGNNLLEEVpEEMKYLTSLKNLHLSGNRICR- 97
Cdd:cd21340    7 LYLNDKNITKID-NLSLCKNLKVLYLYDNKITKI-ENLEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVv 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788651  98 --------------------------FAPGACDGLqnlillnlnnnhltqlpqevsrLKSLTYMSINYNQLASIpRELCF 151
Cdd:cd21340   84 eglenltnleelhienqrlppgekltFDPRSLAAL----------------------SNSLRVLNISGNNIDSL-EPLAP 140

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788651 152 LENLVELQLNYNQLicipeeikflkklqklllarNNIGVLPEELCDLKKLRILDIAGNII 211
Cdd:cd21340  141 LRNLEQLDASNNQI--------------------SDLEELLDLLSSWPSLRELDLTGNPV 180
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 19-257 3.49e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 58.32  E-value: 3.49e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788651  19 ITLNGKKMT-KMPSALGKLPGLKTLVLQNNLIPKVCPE-------------LCN-----------LTQLTTLNLGNNLLE 73
Cdd:PLN00113  74 IDLSGKNISgKISSAIFRLPYIQTINLSNNQLSGPIPDdifttssslrylnLSNnnftgsiprgsIPNLETLDLSNNMLS 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788651  74 -EVPEEMKYLTSLKNLHLSGNRICRFAPGAcdglqnlillnlnnnhltqlpqeVSRLKSLTYMSINYNQL-ASIPRELCF 151
Cdd:PLN00113 154 gEIPNDIGSFSSLKVLDLGGNVLVGKIPNS-----------------------LTNLTSLEFLTLASNQLvGQIPRELGQ 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788651 152 LENLVELQLNYNQLIC-IPEEIKFLKKLQKLLLARNN-IGVLPEELCDLKKLRILDIAGNII--QIFPSGFQDLKLREFY 227
Cdd:PLN00113 211 MKSLKWIYLGYNNLSGeIPYEIGGLTSLNHLDLVYNNlTGPIPSSLGNLKNLQYLFLYQNKLsgPIPPSIFSLQKLISLD 290

                        250       260       270
                 ....*....|....*....|....*....|
gi 193788651 228 CEGNPLFLQQPVISTQQENVWSLQEITSRF 257
Cdd:PLN00113 291 LSDNSLSGEIPELVIQLQNLEILHLFSNNF 320
LRR_8 pfam13855
Leucine rich repeat;
37-95 2.04e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 2.04e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 193788651   37 PGLKTLVLQNNLIPKVCPE-LCNLTQLTTLNLGNNLLEEV-PEEMKYLTSLKNLHLSGNRI 95
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
5-233 2.35e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.01  E-value: 2.35e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788651   5 LLIKALSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNlipkvcPELCNLTQLTTLNLGNNLLEEVPEEMKYLTS 84
Cdd:COG4886   64 SLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------EELSNLTNLESLDLSGNQLTDLPEELANLTN 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788651  85 LKNLHLSGNRIcrfapgacdglqnlillnlnnnhlTQLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQ 164
Cdd:COG4886  138 LKELDLSNNQL------------------------TDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQ 193

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 193788651 165 LICIPEEIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDLKLREFYCEGNPL 233
Cdd:COG4886  194 ITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
6-283 2.72e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.07  E-value: 2.72e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788651   6 LIKALSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPEEMKYLTSL 85
Cdd:COG4886  151 LPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNL 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788651  86 KNLHLSGNRICRFApgacdglqnlillnlnnnhltqlpqEVSRLKSLTYMSINYNQLASIPrELCFLENLVELQLNYNQL 165
Cdd:COG4886  231 ETLDLSNNQLTDLP-------------------------ELGNLTNLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQL 284

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788651 166 ICIPEEIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDLKLREFYCEGNPLFLQQPVISTQQE 245
Cdd:COG4886  285 TDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLT 364

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 193788651 246 NVWSLQEITSRFVMNQLAENNPFLMDDIERYPQVRSMI 283
Cdd:COG4886  365 LLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLL 402
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
8-262 2.06e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.65  E-value: 2.06e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788651   8 KALSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPEeMKYLTSLKN 87
Cdd:COG4886  176 EELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE-LGNLTNLEE 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788651  88 LHLSGNRICRFAPGAcdglqnlillnlnnnhltqlpqevsRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLIC 167
Cdd:COG4886  255 LDLSNNQLTDLPPLA-------------------------NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLN 309

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788651 168 IPEEIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDLKLREFYCEGNPLFLQQPVISTQQENV 247
Cdd:COG4886  310 LLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTL 389

                        250
                 ....*....|....*
gi 193788651 248 WSLQEITSRFVMNQL 262
Cdd:COG4886  390 LLLLLTTTAGVLLLT 404
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 19-211 1.99e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.10  E-value: 1.99e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788651  19 ITLNGKKMTKMPsALGKLPGLKTLVLQNNLIPKVcPELCNLTQLTTLNLGNNLLEEVpEEMKYLTSLKNLHLSGNRICR- 97
Cdd:cd21340    7 LYLNDKNITKID-NLSLCKNLKVLYLYDNKITKI-ENLEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVv 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788651  98 --------------------------FAPGACDGLqnlillnlnnnhltqlpqevsrLKSLTYMSINYNQLASIpRELCF 151
Cdd:cd21340   84 eglenltnleelhienqrlppgekltFDPRSLAAL----------------------SNSLRVLNISGNNIDSL-EPLAP 140

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788651 152 LENLVELQLNYNQLicipeeikflkklqklllarNNIGVLPEELCDLKKLRILDIAGNII 211
Cdd:cd21340  141 LRNLEQLDASNNQI--------------------SDLEELLDLLSSWPSLRELDLTGNPV 180
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 19-257 3.49e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 58.32  E-value: 3.49e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788651  19 ITLNGKKMT-KMPSALGKLPGLKTLVLQNNLIPKVCPE-------------LCN-----------LTQLTTLNLGNNLLE 73
Cdd:PLN00113  74 IDLSGKNISgKISSAIFRLPYIQTINLSNNQLSGPIPDdifttssslrylnLSNnnftgsiprgsIPNLETLDLSNNMLS 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788651  74 -EVPEEMKYLTSLKNLHLSGNRICRFAPGAcdglqnlillnlnnnhltqlpqeVSRLKSLTYMSINYNQL-ASIPRELCF 151
Cdd:PLN00113 154 gEIPNDIGSFSSLKVLDLGGNVLVGKIPNS-----------------------LTNLTSLEFLTLASNQLvGQIPRELGQ 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788651 152 LENLVELQLNYNQLIC-IPEEIKFLKKLQKLLLARNN-IGVLPEELCDLKKLRILDIAGNII--QIFPSGFQDLKLREFY 227
Cdd:PLN00113 211 MKSLKWIYLGYNNLSGeIPYEIGGLTSLNHLDLVYNNlTGPIPSSLGNLKNLQYLFLYQNKLsgPIPPSIFSLQKLISLD 290

                        250       260       270
                 ....*....|....*....|....*....|
gi 193788651 228 CEGNPLFLQQPVISTQQENVWSLQEITSRF 257
Cdd:PLN00113 291 LSDNSLSGEIPELVIQLQNLEILHLFSNNF 320
LRR_8 pfam13855
Leucine rich repeat;
37-95 2.04e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 2.04e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 193788651   37 PGLKTLVLQNNLIPKVCPE-LCNLTQLTTLNLGNNLLEEV-PEEMKYLTSLKNLHLSGNRI 95
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 17-197 1.49e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.76  E-value: 1.49e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788651  17 KIITLNGKKMT-KMPSALGKLPGLKTLVL-QNNLIPKVCPELCNLTQLTTLNL-GNNLLEEVPEEMKYLTSLKNLHLSGN 93
Cdd:PLN00113 191 EFLTLASNQLVgQIPRELGQMKSLKWIYLgYNNLSGEIPYEIGGLTSLNHLDLvYNNLTGPIPSSLGNLKNLQYLFLYQN 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788651  94 RICRFAPGACDGLQNLILLNLNNNHLT-QLPQEVSRLKSLTYMSINYNQL-ASIPRELCFLENLVELQLNYNQLIC-IPE 170
Cdd:PLN00113 271 KLSGPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFtGKIPVALTSLPRLQVLQLWSNKFSGeIPK 350

                        170       180
                 ....*....|....*....|....*...
gi 193788651 171 EIKFLKKLQKLLLARNNI-GVLPEELCD 197
Cdd:PLN00113 351 NLGKHNNLTVLDLSTNNLtGEIPEGLCS 378
PLN03150 PLN03150
hypothetical protein; Provisional
 29-105 3.05e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 45.58  E-value: 3.05e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 193788651  29 MPSALGKLPGLKTLVLQNNLIPKVCP-ELCNLTQLTTLNLGNNLLE-EVPEEMKYLTSLKNLHLSGNRICRFAPGACDG 105
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRGNIPpSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSGRVPAALGG 512
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 32-221 3.98e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 45.17  E-value: 3.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788651  32 ALGKLPGLKTLVLQNNLI-----PKVCPELCNLTQLTTLNLGNNL-----LEEVPEEMKYLTSLKNLHLSGNRICrfAPG 101
Cdd:COG5238  203 ALTQNTTVTTLWLKRNPIgdegaEILAEALKGNKSLTTLDLSNNQigdegVIALAEALKNNTTVETLYLSGNQIG--AEG 280

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788651 102 AcdglqnlillnlnnnhlTQLPQEVSRLKSLTYMSINYNQL-----ASIPRELCFLENLVELQLNYNQL-----ICIPEE 171
Cdd:COG5238  281 A-----------------IALAKALQGNTTLTSLDLSVNRIgdegaIALAEGLQGNKTLHTLNLAYNGIgaqgaIALAKA 343

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 193788651 172 IKFLKKLQKLLLARNNIG-----VLPEELCDLKKLRILDIAGNiiQIFPSGFQDL 221
Cdd:COG5238  344 LQENTTLHSLDLSDNQIGdegaiALAKYLEGNTTLRELNLGKN--NIGKQGAEAL 396
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
58-233 1.74e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.00  E-value: 1.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788651  58 NLTQLTTLNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSI 137
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788651 138 NYNQLASIPRELCFLENLVELQLNYNqlicipEEIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSG 217
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNLTELDLSGN------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEP 154

                        170
                 ....*....|....*..
gi 193788651 218 FQDLK-LREFYCEGNPL 233
Cdd:COG4886  155 LGNLTnLKSLDLSNNQL 171
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 21-160 3.33e-04

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 42.55  E-value: 3.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788651   21 LNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGN-NLLEEVPEEMKYLTSLKNLHLSGnricrfa 99
Cdd:PLN03210  618 MQGSKLEKLWDGVHSLTGLRNIDLRGSKNLKEIPDLSMATNLETLKLSDcSSLVELPSSIQYLNKLEDLDMSR------- 690

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 193788651  100 pgaCDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSINYNQL-------ASIPRELcFLENLVELQL 160
Cdd:PLN03210  691 ---CENLEILPTGINLKSLYRLNLSGCSRLKSFPDISTNISWLdldetaiEEFPSNL-RLENLDELIL 754
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
49-216 1.28e-03

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 40.84  E-value: 1.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788651  49 IPKVCPElcnltQLTTLNLGNNLLEEVPEemkyltslkNLHlsGNricrfapgacdglqnlillnlnnnhltqlpqevsr 128
Cdd:PRK15370 193 IPACIPE-----QITTLILDNNELKSLPE---------NLQ--GN----------------------------------- 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788651 129 LKSLtymSINYNQLASIPRELCflENLVELQLNYNQLICIPEEIkfLKKLQKLLLARNNIGVLPEELCDlkKLRILDIAG 208
Cdd:PRK15370 222 IKTL---YANSNQLTSIPATLP--DTIQEMELSINRITELPERL--PSALQSLDLFHNKISCLPENLPE--ELRYLSVYD 292


                 ....*...
gi 193788651 209 NIIQIFPS 216
Cdd:PRK15370 293 NSIRTLPA 300
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
17-215 1.33e-03

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 40.45  E-value: 1.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788651  17 KIITL--NGKKMTKMPSALGKlpGLKTL-VLQNNL--IPKVCPElcnltQLTTLNLGNNLLEEVPEEMKylTSLKNLHLS 91
Cdd:PRK15370 200 QITTLilDNNELKSLPENLQG--NIKTLyANSNQLtsIPATLPD-----TIQEMELSINRITELPERLP--SALQSLDLF 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788651  92 GNRICRFAPGACDGLQNLILLNLNNNHLtqlPQEVSrlKSLTYMSINYNQLASIPRELCFleNLVELQLNYNQLICIPEE 171
Cdd:PRK15370 271 HNKISCLPENLPEELRYLSVYDNSIRTL---PAHLP--SGITHLNVQSNSLTALPETLPP--GLKTLEAGENALTSLPAS 343

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 193788651 172 IKFLKKLQKLllARNNIGVLPEELCdlKKLRILDIAGNIIQIFP 215
Cdd:PRK15370 344 LPPELQVLDV--SKNQITVLPETLP--PTITTLDVSRNALTNLP 383
LRR_8 pfam13855
Leucine rich repeat;
30-72 1.72e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 1.72e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 193788651   30 PSALGKLPGLKTLVLQNNLIPKVCPE-LCNLTQLTTLNLGNNLL 72
Cdd:pfam13855  18 DGAFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 14-221 6.76e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 38.29  E-value: 6.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788651  14 KNTKIITLNGKKMT-KMPSALGKLPGLKTLVL-QNNLIPKVCPELCNLTQLTTLNLG-NNLLEEVPEEMKYLTSLKNLHL 90
Cdd:PLN00113 308 QNLEILHLFSNNFTgKIPVALTSLPRLQVLQLwSNKFSGEIPKNLGKHNNLTVLDLStNNLTGEIPEGLCSSGNLFKLIL 387

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788651  91 SGNRICRFAP---GACDGLQNLILLNLNNNHLTqlPQEVSRLKSLTYMSINYN----------------QLASIPRELCF 151
Cdd:PLN00113 388 FSNSLEGEIPkslGACRSLRRVRLQDNSFSGEL--PSEFTKLPLVYFLDISNNnlqgrinsrkwdmpslQMLSLARNKFF 465

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788651 152 --------LENLVELQLNYNQLI-CIPEEIKFLKKLQKLLLARNNI-GVLPEELCDLKKLRILDIAGNII--QIfPSGFQ 219
Cdd:PLN00113 466 gglpdsfgSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLsGEIPDELSSCKKLVSLDLSHNQLsgQI-PASFS 544


                 ..
gi 193788651 220 DL 221
Cdd:PLN00113 545 EM 546
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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