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Conserved domains on  [gi|194248057|ref|NP_001123536|]
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neuromodulin isoform 1 [Homo sapiens]

Protein Classification

IQCD and Neuromodulin domain-containing protein( domain architecture ID 12184279)

protein containing domains Adgb_C_mid-like, IQCD, and Neuromodulin

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Neuromodulin pfam06614
Neuromodulin; This family consists of several neuromodulin (Axonal membrane protein GAP-43) ...
 103-274 1.44e-41

Neuromodulin; This family consists of several neuromodulin (Axonal membrane protein GAP-43) sequences and is found in conjunction with pfam00612. GAP-43 is a neuronal calmodulin-binding phosphoprotein that is concentrated in growth cones and pre-synaptic terminals.


:

Pssm-ID: 461961 [Multi-domain]  Cd Length: 175  Bit Score: 141.07  E-value: 1.44e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194248057  103 NKKDEAPVADGVEKK-GEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEG--DAATEQAAPQAPASSEEKAGSAETESA 179
Cdd:pfam06614   1 KKKDEAPAADGVEKKeSEAPTATEAAPAAGAKPDEAGKAGDTPSEEKKGEGaaDAASEQAAPQAPASSEEKAGSAETESA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194248057  180 TKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQ 259
Cdd:pfam06614  81 TKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETAESSQAEEKTEAVDETKPKESARQ 160

                         170
                  ....*....|....*
gi 194248057  260 DEGKEEEPEADQEHA 274
Cdd:pfam06614 161 DEGKEEESEADQEHA 175
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 64-92 1.72e-05

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


:

Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 40.99  E-value: 1.72e-05
                         10        20
                 ....*....|....*....|....*....
gi 194248057  64 EDKAHKAATKIQASFRGHITRKKLKGEKK 92
Cdd:cd23767    5 LQRMNRAATLIQALWRGYKVRKELKKKKK 33
 
Name Accession Description Interval E-value
Neuromodulin pfam06614
Neuromodulin; This family consists of several neuromodulin (Axonal membrane protein GAP-43) ...
 103-274 1.44e-41

Neuromodulin; This family consists of several neuromodulin (Axonal membrane protein GAP-43) sequences and is found in conjunction with pfam00612. GAP-43 is a neuronal calmodulin-binding phosphoprotein that is concentrated in growth cones and pre-synaptic terminals.


Pssm-ID: 461961 [Multi-domain]  Cd Length: 175  Bit Score: 141.07  E-value: 1.44e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194248057  103 NKKDEAPVADGVEKK-GEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEG--DAATEQAAPQAPASSEEKAGSAETESA 179
Cdd:pfam06614   1 KKKDEAPAADGVEKKeSEAPTATEAAPAAGAKPDEAGKAGDTPSEEKKGEGaaDAASEQAAPQAPASSEEKAGSAETESA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194248057  180 TKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQ 259
Cdd:pfam06614  81 TKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETAESSQAEEKTEAVDETKPKESARQ 160

                         170
                  ....*....|....*
gi 194248057  260 DEGKEEEPEADQEHA 274
Cdd:pfam06614 161 DEGKEEESEADQEHA 175
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 64-92 1.72e-05

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 40.99  E-value: 1.72e-05
                         10        20
                 ....*....|....*....|....*....
gi 194248057  64 EDKAHKAATKIQASFRGHITRKKLKGEKK 92
Cdd:cd23767    5 LQRMNRAATLIQALWRGYKVRKELKKKKK 33
IQ smart00015
Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln ...
 66-88 2.67e-05

Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln residues.


Pssm-ID: 197470 [Multi-domain]  Cd Length: 23  Bit Score: 40.00  E-value: 2.67e-05
                           10        20
                   ....*....|....*....|...
gi 194248057    66 KAHKAATKIQASFRGHITRKKLK 88
Cdd:smart00015   1 RLTRAAIIIQAAWRGYLARKRYK 23
IQ pfam00612
IQ calmodulin-binding motif; Calmodulin-binding motif.
 68-88 5.49e-05

IQ calmodulin-binding motif; Calmodulin-binding motif.


Pssm-ID: 459869  Cd Length: 21  Bit Score: 39.22  E-value: 5.49e-05
                          10        20
                  ....*....|....*....|.
gi 194248057   68 HKAATKIQASFRGHITRKKLK 88
Cdd:pfam00612   1 RKAAIKIQAAWRGYLARKRYK 21
PTZ00121 PTZ00121
MAEBL; Provisional
 49-268 3.64e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.05  E-value: 3.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194248057   49 KNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEaEANKKDEAPVADGVEKKGEGTTTAEAAP 128
Cdd:PTZ00121 1243 KKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKAD-EAKKAEEKKKADEAKKKAEEAKKADEAK 1321

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194248057  129 ATGSKPDEPGKAGETPSEEKKGEGDAAT--EQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADV 206
Cdd:PTZ00121 1322 KKAEEAKKKADAAKKKAEEAKKAAEAAKaeAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAE 1401

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 194248057  207 PAAVTAAAATTPAAEDAAAKATAQPPTETGESSQ----AEENIEAVDETKPKESARQDEGKEEEPE 268
Cdd:PTZ00121 1402 EDKKKADELKKAAAAKKKADEAKKKAEEKKKADEakkkAEEAKKADEAKKKAEEAKKAEEAKKKAE 1467
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 50-272 7.23e-04

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 40.75  E-value: 7.23e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194248057    50 NDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRK-KLKGEKKDDvQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAP 128
Cdd:TIGR00927  647 EEGERPTEAEGENGEESGGEAEQEGETETKGENESEgEIPAERKGE-QEGEGEIEAKEADHKGETEAEEVEHEGETEAEG 725

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194248057   129 ATGSKPDEPGKAGETPSEEKKGEGDAATEqaaPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPA 208
Cdd:TIGR00927  726 TEDEGEIETGEEGEEVEDEGEGEAEGKHE---VETEGDRKETEHEGETEAEGKEDEDEGEIQAGEDGEMKGDEGAEGKVE 802

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 194248057   209 AVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEG-------KEEEPEADQE 272
Cdd:TIGR00927  803 HEGETEAGEKDEHEGQSETQADDTEVKDETGEQELNAENQGEAKQDEKGVDGGGgsdggdsEEEEEEEEEE 873
 
Name Accession Description Interval E-value
Neuromodulin pfam06614
Neuromodulin; This family consists of several neuromodulin (Axonal membrane protein GAP-43) ...
 103-274 1.44e-41

Neuromodulin; This family consists of several neuromodulin (Axonal membrane protein GAP-43) sequences and is found in conjunction with pfam00612. GAP-43 is a neuronal calmodulin-binding phosphoprotein that is concentrated in growth cones and pre-synaptic terminals.


Pssm-ID: 461961 [Multi-domain]  Cd Length: 175  Bit Score: 141.07  E-value: 1.44e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194248057  103 NKKDEAPVADGVEKK-GEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEG--DAATEQAAPQAPASSEEKAGSAETESA 179
Cdd:pfam06614   1 KKKDEAPAADGVEKKeSEAPTATEAAPAAGAKPDEAGKAGDTPSEEKKGEGaaDAASEQAAPQAPASSEEKAGSAETESA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194248057  180 TKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQ 259
Cdd:pfam06614  81 TKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETAESSQAEEKTEAVDETKPKESARQ 160

                         170
                  ....*....|....*
gi 194248057  260 DEGKEEEPEADQEHA 274
Cdd:pfam06614 161 DEGKEEESEADQEHA 175
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 64-92 1.72e-05

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 40.99  E-value: 1.72e-05
                         10        20
                 ....*....|....*....|....*....
gi 194248057  64 EDKAHKAATKIQASFRGHITRKKLKGEKK 92
Cdd:cd23767    5 LQRMNRAATLIQALWRGYKVRKELKKKKK 33
IQ smart00015
Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln ...
 66-88 2.67e-05

Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln residues.


Pssm-ID: 197470 [Multi-domain]  Cd Length: 23  Bit Score: 40.00  E-value: 2.67e-05
                           10        20
                   ....*....|....*....|...
gi 194248057    66 KAHKAATKIQASFRGHITRKKLK 88
Cdd:smart00015   1 RLTRAAIIIQAAWRGYLARKRYK 23
IQ pfam00612
IQ calmodulin-binding motif; Calmodulin-binding motif.
 68-88 5.49e-05

IQ calmodulin-binding motif; Calmodulin-binding motif.


Pssm-ID: 459869  Cd Length: 21  Bit Score: 39.22  E-value: 5.49e-05
                          10        20
                  ....*....|....*....|.
gi 194248057   68 HKAATKIQASFRGHITRKKLK 88
Cdd:pfam00612   1 RKAAIKIQAAWRGYLARKRYK 21
PTZ00121 PTZ00121
MAEBL; Provisional
 49-268 3.64e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.05  E-value: 3.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194248057   49 KNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEaEANKKDEAPVADGVEKKGEGTTTAEAAP 128
Cdd:PTZ00121 1243 KKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKAD-EAKKAEEKKKADEAKKKAEEAKKADEAK 1321

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194248057  129 ATGSKPDEPGKAGETPSEEKKGEGDAAT--EQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADV 206
Cdd:PTZ00121 1322 KKAEEAKKKADAAKKKAEEAKKAAEAAKaeAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAE 1401

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 194248057  207 PAAVTAAAATTPAAEDAAAKATAQPPTETGESSQ----AEENIEAVDETKPKESARQDEGKEEEPE 268
Cdd:PTZ00121 1402 EDKKKADELKKAAAAKKKADEAKKKAEEKKKADEakkkAEEAKKADEAKKKAEEAKKAEEAKKKAE 1467
Adgb_C_mid-like cd22307
C-terminal middle region of Androglobins (Adgbs) and related proteins; including permuted ...
 50-88 4.34e-04

C-terminal middle region of Androglobins (Adgbs) and related proteins; including permuted globin domain and IQ motif; Androglobin (Adgb, also known as Calpain-7-like protein, CAPN7L) is a large multidomain protein consisting of an N-terminal peptidase C2 family calpain-like domain, an IQ calmodulin-binding motif, and an internal, circularly permuted globin domain. The canonical secondary structure of hemoglobins is an 3-over-3 alpha-helical sandwich structure, where the eight alpha-helical segments are conventionally labeled, A-H, according to their sequential order; Adgbs differ from this in having helices C-H followed by A-B. Adgbs and other phylogenetically ancient globins, such as neuroglobins and globin X, form hexacoordinated heme iron complexes. Globins contain various highly conserved residues of the heme pocket: including a Phe in the interhelical position CD1 (Phe CD1, first position in the loop between the helices C and D) that is packed against the heme, a His at the 7th position of the E-helix (His E7) that binds the heme iron distally, and a His at the 8th position of the F-helix (His F8) that binds the heme iron proximally. Unlike other hexacoordinated globins, Adgbs have an E7 Gln; their hexacoordination scheme is [Gln]-Fe-[His]. In mammals, Adgb is mainly expressed in the testes and may play an important role in spermatogenesis. Arthropod Adgbs have degenerate globin domains (DOI:10.3389/fgene.2020.00858). This model spans the permuted globin domain, the IQ motif, and a conserved region of about 200 amino acid residues located C-terminal to the globin domain; it does not include the N-terminal protease domain or the large uncharacterized C-terminal domain of approximately 500 residues.


Pssm-ID: 412094  Cd Length: 416  Bit Score: 41.38  E-value: 4.34e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 194248057  50 NDDDQKIEQDGI--KPEDKAHKAATKIQASFRGHITRKKLK 88
Cdd:cd22307  127 REIVEPDECDCRtrEPTIEEHEAATKIQAFFRGTLVRKLLK 167
PRK13108 PRK13108
prolipoprotein diacylglyceryl transferase; Reviewed
 89-202 7.21e-04

prolipoprotein diacylglyceryl transferase; Reviewed


Pssm-ID: 237284 [Multi-domain]  Cd Length: 460  Bit Score: 40.73  E-value: 7.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194248057  89 GEKKDDVQAAEAEANKKDE--APVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPAS 166
Cdd:PRK13108 310 SAASAVGPVGPGEPNQPDDvaEAVKAEVAEVTDEVAAESVVQVADRDGESTPAVEETSEADIEREQPGDLAGQAPAAHQV 389

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 194248057 167 SEEKAGSAETESATKASTDnsPSSKAEDAPAKEEPK 202
Cdd:PRK13108 390 DAEAASAAPEEPAALASEA--HDETEPEVPEKAAPI 423
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 50-272 7.23e-04

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 40.75  E-value: 7.23e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194248057    50 NDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRK-KLKGEKKDDvQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAP 128
Cdd:TIGR00927  647 EEGERPTEAEGENGEESGGEAEQEGETETKGENESEgEIPAERKGE-QEGEGEIEAKEADHKGETEAEEVEHEGETEAEG 725

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194248057   129 ATGSKPDEPGKAGETPSEEKKGEGDAATEqaaPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPA 208
Cdd:TIGR00927  726 TEDEGEIETGEEGEEVEDEGEGEAEGKHE---VETEGDRKETEHEGETEAEGKEDEDEGEIQAGEDGEMKGDEGAEGKVE 802

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 194248057   209 AVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEG-------KEEEPEADQE 272
Cdd:TIGR00927  803 HEGETEAGEKDEHEGQSETQADDTEVKDETGEQELNAENQGEAKQDEKGVDGGGgsdggdsEEEEEEEEEE 873
PTZ00121 PTZ00121
MAEBL; Provisional
 48-266 1.54e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.12  E-value: 1.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194248057   48 EKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAA 127
Cdd:PTZ00121 1328 KKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKA 1407

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194248057  128 PATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVP 207
Cdd:PTZ00121 1408 DELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADE 1487

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 194248057  208 AAVTAAAATTPAAEDAAAKATAQpptETGESSQAEENIEAVDETKPKESARQDEGKEEE 266
Cdd:PTZ00121 1488 AKKKAEEAKKKADEAKKAAEAKK---KADEAKKAEEAKKADEAKKAEEAKKADEAKKAE 1543
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 92-272 2.78e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 39.21  E-value: 2.78e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194248057    92 KDDVQAAEAEANKKDE--APVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEeKKGEGDAATEQAAPQAPASSEE 169
Cdd:TIGR00927  632 KGDVAEAEHTGERTGEegERPTEAEGENGEESGGEAEQEGETETKGENESEGEIPAE-RKGEQEGEGEIEAKEADHKGET 710

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194248057   170 KAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESS---QAEENIE 246
Cdd:TIGR00927  711 EAEEVEHEGETEAEGTEDEGEIETGEEGEEVEDEGEGEAEGKHEVETEGDRKETEHEGETEAEGKEDEDEgeiQAGEDGE 790

                          170       180
                   ....*....|....*....|....*.
gi 194248057   247 AVDETKPKESARQDEGKEEEPEADQE 272
Cdd:TIGR00927  791 MKGDEGAEGKVEHEGETEAGEKDEHE 816
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 90-268 3.59e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 38.82  E-value: 3.59e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194248057    90 EKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGK-----AGETPSEEKKGEGDAATEQAAPQAP 164
Cdd:TIGR00927  639 EHTGERTGEEGERPTEAEGENGEESGGEAEQEGETETKGENESEGEIPAErkgeqEGEGEIEAKEADHKGETEAEEVEHE 718

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194248057   165 ASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQpPTETGESSQAEEN 244
Cdd:TIGR00927  719 GETEAEGTEDEGEIETGEEGEEVEDEGEGEAEGKHEVETEGDRKETEHEGETEAEGKEDEDEGEIQ-AGEDGEMKGDEGA 797

                          170       180
                   ....*....|....*....|....
gi 194248057   245 IEAVDETKPKESARQDEGKEEEPE 268
Cdd:TIGR00927  798 EGKVEHEGETEAGEKDEHEGQSET 821
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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