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Conserved domains on  [gi|288856329|ref|NP_001124138|]
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myosin, heavy polypeptide 1.1, skeletal muscle [Danio rerio]

Protein Classification

myosin heavy chain( domain architecture ID 13677817)

myosin heavy chain of class II myosin (or conventional myosin), which contains two heavy chains made up of the motor/head (N-terminal) and coiled-coil tail (C-terminal) domains; the head ATPase activity and functions as a molecular motor, utilizing ATP hydrolysis to generate directed movement toward the plus end along actin filaments

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MYSc_class_II cd01377
class II myosins, motor domain; Myosin motor domain in class II myosins. Class II myosins, ...
101-768 0e+00

class II myosins, motor domain; Myosin motor domain in class II myosins. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. Thus, myosin II has two heads. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


:

Pssm-ID: 276951 [Multi-domain]  Cd Length: 662  Bit Score: 1279.71  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  101 PSVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLITG 180
Cdd:cd01377     1 ASVLHNLRERYYSDLIYTYSGLFCVAVNPYKRLPIYTEEVIDKYKGKRREEMPPHIFAIADNAYRNMLQDRENQSILITG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  181 ESGAGKTVNTKRVIQYFATVAVQGPEKKKEqasGKMQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTSG 260
Cdd:cd01377    81 ESGAGKTENTKKVIQYLASVAASSKKKKES---GKKKGTLEDQILQANPILEAFGNAKTVRNNNSSRFGKFIRIHFGSTG 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  261 KLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPELIEMTLITTNPYDFPMCSQGQITVASIDDKEELVATDTAI 340
Cdd:cd01377   158 KIAGADIETYLLEKSRVVRQAKGERNYHIFYQLLSGADPELKEKLLLTGDPSYYFFLSQGELTIDGVDDAEEFKLTDEAF 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  341 DILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQREEQAEPDGTEEADKIGYLLGLNSADMLKALCYPRVKVGNEFVTKGQT 420
Cdd:cd01377   238 DILGFSEEEKMSIFKIVAAILHLGNIKFKQRRREEQAELDGTEEADKAAHLLGVNSSDLLKALLKPRIKVGREWVTKGQN 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  421 VPQVYNSVSALSKSIYERMFLWMVVRINQMLDTKQQRNFFIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFNHHMFVL 500
Cdd:cd01377   318 KEQVVFSVGALAKALYERLFLWLVKRINKTLDTKSKRQYFIGVLDIAGFEIFEFNSFEQLCINYTNEKLQQFFNHHMFVL 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  501 EQEEYKKEGIVWEFIDFGMDLAACIELIEKP-LGIFSILEEECMFPKATDTSFKNKLYDQHLGKCNAFQKPKPakGKAEA 579
Cdd:cd01377   398 EQEEYKKEGIEWTFIDFGLDLQPTIDLIEKPnMGILSILDEECVFPKATDKTFVEKLYSNHLGKSKNFKKPKP--KKSEA 475
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  580 HFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYPPVVEETgGGKKGGKKKGGSMQTVSSQFRENLGK 659
Cdd:cd01377   476 HFILKHYAGDVEYNIDGWLEKNKDPLNENVVALLKKSSDPLVASLFKDYEESG-GGGGKKKKKGGSFRTVSQLHKEQLNK 554
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  660 LMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASVIPEGQFiD 739
Cdd:cd01377   555 LMTTLRSTHPHFVRCIIPNEEKKPGKIDAPLVLHQLRCNGVLEGIRICRKGFPNRIIFAEFKQRYSILAPNAIPKGFD-D 633
                         650       660
                  ....*....|....*....|....*....
gi 288856329  740 NKKASEKLLGSIDVNHDEYRFGHTKVFFK 768
Cdd:cd01377   634 GKAACEKILKALQLDPELYRIGNTKVFFK 662
Myosin_tail_1 super family cl37647
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
848-1925 4.49e-162

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


The actual alignment was detected with superfamily member pfam01576:

Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 526.67  E-value: 4.49e-162
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   848 EKELATMKEDFVKCKEDLAKAEAKKKELEEKMVALLQEKNDLQLAVASESENLSDAEERCEGLIKSKIQLEAKLKETTER 927
Cdd:pfam01576    4 EEEMQAKEEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLQAETELCAEAEEMRARLAARKQELEEILHELESR 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   928 LEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAAQDESIGKLTKEKKALQEAHQQ 1007
Cdd:pfam01576   84 LEEEEERSQQLQNEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLLEDQNSKLSKERKLLEERISE 163
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1008 TLDDLQAEEDKVNTLTKSKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDLENDKQQSEEKLKKKDF 1087
Cdd:pfam01576  164 FTSNLAEEEEKAKSLSKLKNKHEAMISDLEERLKKEEKGRQELEKAKRKLEGESTDLQEQIAELQAQIAELRAQLAKKEE 243
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1088 ETSQLLSKIEDEQSLGAQLQKKIKELQARIEELEEEIEAERAARAKVEKQRADLSRELEEISERLEEAGGATAAQIEMNK 1167
Cdd:pfam01576  244 ELQAALARLEEETAQKNNALKKIRELEAQISELQEDLESERAARNKAEKQRRDLGEELEALKTELEDTLDTTAAQQELRS 323
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1168 KREAEFQKLRRDLEESTLQHEATAAALRKKQADSVAELGEQIDNLQRVKQKLEKEKSEYKMEIDDLSSNMEAVAKAKANL 1247
Cdd:pfam01576  324 KREQEVTELKKALEEETRSHEAQLQEMRQKHTQALEELTEQLEQAKRNKANLEKAKQALESENAELQAELRTLQQAKQDS 403
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1248 EKMCRTLEDQLSEIKSKNDENLRQINDLSAQRARLQTENGEFGRQLEEKEALVSQLTRGKQAFTQQIEELKRQIEEEVKA 1327
Cdd:pfam01576  404 EHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDVSSLESQLQDTQELLQEETRQ 483
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1328 KNALAHAVQSARHDCDLLREQFEEEQEAKAELQRGMSKANSEVAQWRTKYETDAiQRTEELEESKKKLAQRLQEAEEQIE 1407
Cdd:pfam01576  484 KLNLSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLEEDA-GTLEALEEGKKRLQRELEALTQQLE 562
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1408 AVNSKCASLEKTKQRLQGEVEDLMIDVERANALAANLDKKQRNFDKVLAEWKQKYEEGQAELEGAQKEARSLSTELFKMK 1487
Cdd:pfam01576  563 EKAAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNLEKKQKKFDQMLAEEKAISARYAEERDRAEAEAREKETRALSLA 642
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1488 NSYEETLDQLETLKRENKNLQQEISDLTEQLGETGKSIHELEKSKKAVETEKAEIQTALEEAEGTLEHEESKILRVQLEL 1567
Cdd:pfam01576  643 RALEEALEAKEELERTNKQLRAEMEDLVSSKDDVGKNVHELERSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNM 722
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1568 NQVKSEIDRKLAEKDEEIEQIKRNSQRITDSMQSTLDSEVRSRNDALRIKKKMEGDLNEMEIQLSHANRQAAEAQKQLRN 1647
Cdd:pfam01576  723 QALKAQFERDLQARDEQGEEKRRQLVKQVRELEAELEDERKQRAQAVAAKKKLELDLKELEAQIDAANKGREEAVKQLKK 802
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1648 VQAQLKDAQLHLDDAVRGQEDMKEQVAMVERRNTLMQSEIEELRAALEQTERGRKVAEQELVDASERVGLLHSQNTSLLN 1727
Cdd:pfam01576  803 LQAQMKDLQRELEEARASRDEILAQSKESEKKLKNLEAELLQLQEDLAASERARRQAQQERDELADEIASGASGKSALQD 882
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1728 TKKKLEADLVQIQSEVEDTVQEARNAEDKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEVTVKDLQHRLDEAENLAM 1807
Cdd:pfam01576  883 EKRRLEARIAQLEEELEEEQSNTELLNDRLRKSTLQVEQLTTELAAERSTSQKSESARQQLERQNKELKAKLQEMEGTVK 962
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1808 KGGKKQLQKLESRVRELESEVEAEQRRGADAVKGVRKYERRVKELTYQTEEDKKNVNRLQDLVDKLQLKVKAYKRQSEEA 1887
Cdd:pfam01576  963 SKFKSSIAALEAKIAQLEEQLEQESRERQAANKLVRRTEKKLKEVLLQVEDERRHADQYKDQAEKGNSRMKQLKRQLEEA 1042
                         1050      1060      1070
                   ....*....|....*....|....*....|....*...
gi 288856329  1888 EEQANSHLSKLRKVQHELEEAEERADIAESQVNKLRAK 1925
Cdd:pfam01576 1043 EEEASRANAARRKLQRELDDATESNESMNREVSTLKSK 1080
Myosin_N pfam02736
Myosin N-terminal SH3-like domain; This domain has an SH3-like fold. It is found at the ...
33-78 1.39e-11

Myosin N-terminal SH3-like domain; This domain has an SH3-like fold. It is found at the N-terminus of many but not all myosins. The function of this domain is unknown.


:

Pssm-ID: 460670  Cd Length: 45  Bit Score: 60.91  E-value: 1.39e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 288856329    33 DAKTACYVVDDKELYVKGTIKSKDGGKVTVITlDTKEEKVVKEDDV 78
Cdd:pfam02736    1 DAKKLVWVPDPKEGFVKGEIKEEEGDKVTVET-EDGKTVTVKKDDV 45
 
Name Accession Description Interval E-value
MYSc_class_II cd01377
class II myosins, motor domain; Myosin motor domain in class II myosins. Class II myosins, ...
101-768 0e+00

class II myosins, motor domain; Myosin motor domain in class II myosins. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. Thus, myosin II has two heads. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276951 [Multi-domain]  Cd Length: 662  Bit Score: 1279.71  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  101 PSVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLITG 180
Cdd:cd01377     1 ASVLHNLRERYYSDLIYTYSGLFCVAVNPYKRLPIYTEEVIDKYKGKRREEMPPHIFAIADNAYRNMLQDRENQSILITG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  181 ESGAGKTVNTKRVIQYFATVAVQGPEKKKEqasGKMQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTSG 260
Cdd:cd01377    81 ESGAGKTENTKKVIQYLASVAASSKKKKES---GKKKGTLEDQILQANPILEAFGNAKTVRNNNSSRFGKFIRIHFGSTG 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  261 KLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPELIEMTLITTNPYDFPMCSQGQITVASIDDKEELVATDTAI 340
Cdd:cd01377   158 KIAGADIETYLLEKSRVVRQAKGERNYHIFYQLLSGADPELKEKLLLTGDPSYYFFLSQGELTIDGVDDAEEFKLTDEAF 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  341 DILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQREEQAEPDGTEEADKIGYLLGLNSADMLKALCYPRVKVGNEFVTKGQT 420
Cdd:cd01377   238 DILGFSEEEKMSIFKIVAAILHLGNIKFKQRRREEQAELDGTEEADKAAHLLGVNSSDLLKALLKPRIKVGREWVTKGQN 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  421 VPQVYNSVSALSKSIYERMFLWMVVRINQMLDTKQQRNFFIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFNHHMFVL 500
Cdd:cd01377   318 KEQVVFSVGALAKALYERLFLWLVKRINKTLDTKSKRQYFIGVLDIAGFEIFEFNSFEQLCINYTNEKLQQFFNHHMFVL 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  501 EQEEYKKEGIVWEFIDFGMDLAACIELIEKP-LGIFSILEEECMFPKATDTSFKNKLYDQHLGKCNAFQKPKPakGKAEA 579
Cdd:cd01377   398 EQEEYKKEGIEWTFIDFGLDLQPTIDLIEKPnMGILSILDEECVFPKATDKTFVEKLYSNHLGKSKNFKKPKP--KKSEA 475
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  580 HFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYPPVVEETgGGKKGGKKKGGSMQTVSSQFRENLGK 659
Cdd:cd01377   476 HFILKHYAGDVEYNIDGWLEKNKDPLNENVVALLKKSSDPLVASLFKDYEESG-GGGGKKKKKGGSFRTVSQLHKEQLNK 554
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  660 LMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASVIPEGQFiD 739
Cdd:cd01377   555 LMTTLRSTHPHFVRCIIPNEEKKPGKIDAPLVLHQLRCNGVLEGIRICRKGFPNRIIFAEFKQRYSILAPNAIPKGFD-D 633
                         650       660
                  ....*....|....*....|....*....
gi 288856329  740 NKKASEKLLGSIDVNHDEYRFGHTKVFFK 768
Cdd:cd01377   634 GKAACEKILKALQLDPELYRIGNTKVFFK 662
Myosin_head pfam00063
Myosin head (motor domain);
89-768 0e+00

Myosin head (motor domain);


Pssm-ID: 395017 [Multi-domain]  Cd Length: 674  Bit Score: 1000.64  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329    89 IEDMAMMTHLNEPSVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFML 168
Cdd:pfam00063    1 VEDMVELSYLNEPSVLHNLKKRYKSDLIYTYSGLVLVAVNPYKQLPIYSEDMIKAYRGKRRGELPPHIFAIADEAYRSML 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   169 TDRENQSVLITGESGAGKTVNTKRVIQYFATVAVQGPEKKKeqasgkmqGSLEDQIIAANPLLEAYGNAKTVRNDNSSRF 248
Cdd:pfam00063   81 QDKENQSILISGESGAGKTENTKKIMQYLASVSGSGSAGNV--------GRLEEQILQSNPILEAFGNAKTVRNNNSSRF 152
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   249 GKFIRIHFGTSGKLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPELIEmTLITTNPYDFPMCSQ-GQITVASI 327
Cdd:pfam00063  153 GKYIEIQFDAKGDIVGGKIETYLLEKSRVVYQAEGERNYHIFYQLLAGASAQLKK-ELRLTNPKDYHYLSQsGCYTIDGI 231
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   328 DDKEELVATDTAIDILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQREEQAEPDGTEEADKIGYLLGLNSADMLKALCYPR 407
Cdd:pfam00063  232 DDSEEFKITDKAMDILGFSDEEQMGIFRIVAAILHLGNIEFKKERNDEQAVPDDTENLQKAASLLGIDSTELEKALCKRR 311
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   408 VKVGNEFVTKGQTVPQVYNSVSALSKSIYERMFLWMVVRINQMLDTKQ-QRNFFIGVLDIAGFEIFDFNSMEQLCINFTN 486
Cdd:pfam00063  312 IKTGRETVSKPQNVEQANYARDALAKAIYSRLFDWLVDRINKSLDVKTiEKASFIGVLDIYGFEIFEKNSFEQLCINYVN 391
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   487 EKLQQFFNHHMFVLEQEEYKKEGIVWEFIDFGmDLAACIELIE-KPLGIFSILEEECMFPKATDTSFKNKLYDQHlGKCN 565
Cdd:pfam00063  392 EKLQQFFNHHMFKLEQEEYVREGIEWTFIDFG-DNQPCIDLIEkKPLGILSLLDEECLFPKATDQTFLDKLYSTF-SKHP 469
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   566 AFQKPKPakgKAEAHFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYPPVVEETGGGKKGGKKKG-- 643
Cdd:pfam00063  470 HFQKPRL---QGETHFIIKHYAGDVEYNVEGFLEKNKDPLNDDLVSLLKSSSDPLLAELFPDYETAESAAANESGKSTpk 546
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   644 ----GSMQTVSSQFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYAD 719
Cdd:pfam00063  547 rtkkKRFITVGSQFKESLGELMKTLNSTNPHYIRCIKPNEKKRAGVFDNSLVLHQLRCNGVLEGIRIRRAGFPNRITFQE 626
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*....
gi 288856329   720 FKQRYKVLNASVIPEGqFIDNKKASEKLLGSIDVNHDEYRFGHTKVFFK 768
Cdd:pfam00063  627 FVQRYRILAPKTWPKW-KGDAKKGCEAILQSLNLDKEEYQFGKTKIFFR 674
MYSc smart00242
Myosin. Large ATPases; ATPase; molecular motor. Muscle contraction consists of a cyclical ...
82-780 0e+00

Myosin. Large ATPases; ATPase; molecular motor. Muscle contraction consists of a cyclical interaction between myosin and actin. The core of the myosin structure is similar in fold to that of kinesin.


Pssm-ID: 214580 [Multi-domain]  Cd Length: 677  Bit Score: 965.86  E-value: 0e+00
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329     82 NPPKFDKIEDMAMMTHLNEPSVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRMEAPPHIFSVSD 161
Cdd:smart00242    1 NPPKFEGVEDLVLLTYLNEPAVLHNLKKRYLKDLIYTYIGLVLVAVNPYKQLPIYTDEVIKKYRGKSRGELPPHVFAIAD 80
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329    162 NAYQFMLTDRENQSVLITGESGAGKTVNTKRVIQYFATVAvqgpekkkeqASGKMQGSLEDQIIAANPLLEAYGNAKTVR 241
Cdd:smart00242   81 NAYRNMLNDKENQSIIISGESGAGKTENTKKIMQYLASVS----------GSNTEVGSVEDQILESNPILEAFGNAKTLR 150
                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329    242 NDNSSRFGKFIRIHFGTSGKLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPELIEmTLITTNPYDFPMCSQGQ 321
Cdd:smart00242  151 NNNSSRFGKFIEIHFDAKGKIIGAKIETYLLEKSRVVSQAKGERNYHIFYQLLAGASEELKK-ELGLKSPEDYRYLNQGG 229
                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329    322 -ITVASIDDKEELVATDTAIDILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQREEQA-EPDGTEEADKIGYLLGLNSADM 399
Cdd:smart00242  230 cLTVDGIDDAEEFKETLNAMRVLGFSEEEQESIFKILAAILHLGNIEFEEGRNDNAAsTVKDKEELSNAAELLGVDPEEL 309
                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329    400 LKALCYPRVKVGNEFVTKGQTVPQVYNSVSALSKSIYERMFLWMVVRINQMLDTKQQRNFFIGVLDIAGFEIFDFNSMEQ 479
Cdd:smart00242  310 EKALTKRKIKTGGEVITKPLNVEQALDARDALAKALYSRLFDWLVKRINQSLSFKDGSTYFIGVLDIYGFEIFEVNSFEQ 389
                           410       420       430       440       450       460       470       480
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329    480 LCINFTNEKLQQFFNHHMFVLEQEEYKKEGIVWEFIDFGmDLAACIELIE-KPLGIFSILEEECMFPKATDTSFKNKLYd 558
Cdd:smart00242  390 LCINYANEKLQQFFNQHVFKLEQEEYEREGIDWTFIDFF-DNQDCIDLIEkKPPGILSLLDEECRFPKGTDQTFLEKLN- 467
                           490       500       510       520       530       540       550       560
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329    559 QHLGKCNAFQKPKPakgKAEAHFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYPPVVEETgggkkg 638
Cdd:smart00242  468 QHHKKHPHFSKPKK---KGRTEFIIKHYAGDVTYDVTGFLEKNKDTLSDDLIELLQSSKNPLIASLFPSGVSNA------ 538
                           570       580       590       600       610       620       630       640
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329    639 gkKKGGSMQTVSSQFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYA 718
Cdd:smart00242  539 --GSKKRFQTVGSQFKEQLNELMDTLNSTNPHFIRCIKPNEEKKPGDFDSSLVLHQLRYLGVLENIRIRRAGFPYRLPFD 616
                           650       660       670       680       690       700
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 288856329    719 DFKQRYKVLNASVIPEGQFiDNKKASEKLLGSIDVNHDEYRFGHTKVFFKAGLLGTLEEMRD 780
Cdd:smart00242  617 EFLQRYRVLLPDTWPPWGG-DAKKACEALLQSLGLDEDEYQLGKTKVFLRPGQLAELEELRE 677
COG5022 COG5022
Myosin heavy chain [General function prediction only];
32-1114 0e+00

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 809.69  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   32 FDAKTACYVVDDKELYVKGTIKSKD--GGKVTV------ITLDTKEEKVVKEDDvhpMNPPKFDKIEDMAMMTHLNEPSV 103
Cdd:COG5022     6 AEVGSGCWIPDEEKGWIWAEIIKEAfnKGKVTEegkkedGESVSVKKKVLGNDR---IKLPKFDGVDDLTELSYLNEPAV 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  104 LYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLITGESG 183
Cdd:COG5022    83 LHNLEKRYNNGQIYTYSGLVLIAVNPYRDLGIYTDDIIQSYSGKNRLELEPHVFAIAEEAYRNLLSEKENQTIIISGESG 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  184 AGKTVNTKRVIQYFATVavqgpekkkEQASGKMQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTSGKLA 263
Cdd:COG5022   163 AGKTENAKRIMQYLASV---------TSSSTVEISSIEKQILATNPILEAFGNAKTVRNDNSSRFGKYIKIEFDENGEIC 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  264 SADIETYLLEKSRVTFQLPDERGYHIFYQMMTNhKPELIEMTLITTNPYDFPMCSQG-QITVASIDDKEELVATDTAIDI 342
Cdd:COG5022   234 GAKIETYLLEKSRVVHQNKNERNYHIFYQLLAG-DPEELKKLLLLQNPKDYIYLSQGgCDKIDGIDDAKEFKITLDALKT 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  343 LGFNNEEKMGIYKFTGAVLHHGNMKFKqKQREEQAEPDGTEEADKIGYLLGLNSADMLKALCYPRVKVGNEFVTKGQTVP 422
Cdd:COG5022   313 IGIDEEEQDQIFKILAAILHIGNIEFK-EDRNGAAIFSDNSVLDKACYLLGIDPSLFVKWLVKRQIKTGGEWIVVPLNLE 391
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  423 QVYNSVSALSKSIYERMFLWMVVRINQMLDTKQQRNFFIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFNHHMFVLEQ 502
Cdd:COG5022   392 QALAIRDSLAKALYSNLFDWIVDRINKSLDHSAAASNFIGVLDIYGFEIFEKNSFEQLCINYTNEKLQQFFNQHMFKLEQ 471
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  503 EEYKKEGIVWEFIDFgMDLAACIELIEK--PLGIFSILEEECMFPKATDTSFKNKLYDQ-HLGKCNAFQKPKPAKGKaea 579
Cdd:COG5022   472 EEYVKEGIEWSFIDY-FDNQPCIDLIEKknPLGILSLLDEECVMPHATDESFTSKLAQRlNKNSNPKFKKSRFRDNK--- 547
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  580 hFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYPPVVEetgggkkggKKKGGSMQTVSSQFRENLGK 659
Cdd:COG5022   548 -FVVKHYAGDVEYDVEGFLDKNKDPLNDDLLELLKASTNEFVSTLFDDEEN---------IESKGRFPTLGSRFKESLNS 617
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  660 LMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASVIPEGQFI- 738
Cdd:COG5022   618 LMSTLNSTQPHYIRCIKPNEEKSPWTFDNQMVLSQLRCCGVLETIRISRAGFPSRWTFDEFVQRYRILSPSKSWTGEYTw 697
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  739 --DNKKASEKLLGSIDVNHDEYRFGHTKVFFKAGLLGTLEEMRDEKLASLVTMTQALCRAYLMRREFVKMMERRDAIYTI 816
Cdd:COG5022   698 keDTKNAVKSILEELVIDSSKYQIGNTKVFFKAGVLAALEDMRDAKLDNIATRIQRAIRGRYLRRRYLQALKRIKKIQVI 777
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  817 QYNVRSFMNVKHWPWMKVYYKIKPLLKSAETEKELatmkEDFVKCKEDLAKAEAKKKELEEKMVALLQEKNDLQLAVASE 896
Cdd:COG5022   778 QHGFRLRRLVDYELKWRLFIKLQPLLSLLGSRKEY----RSYLACIIKLQKTIKREKKLRETEEVEFSLKAEVLIQKFGR 853
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  897 SENLS---DAEERCEGLIKSKIQLEAKLKETTERLEDEEEINaELTAKKRKLEDECSELKKDID-----DLELTLAKVEK 968
Cdd:COG5022   854 SLKAKkrfSLLKKETIYLQSAQRVELAERQLQELKIDVKSIS-SLKLVNLELESEIIELKKSLSsdlieNLEFKTELIAR 932
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  969 EKHATEN-KVKNLTEEMAAQDESIGKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKSKTKLEQQVDDLEGSLEQekklR 1047
Cdd:COG5022   933 LKKLLNNiDLEEGPSIEYVKLPELNKLHEVESKLKETSEEYEDLLKKSTILVREGNKANSELKNFKKELAELSKQ----Y 1008
                        1050      1060      1070      1080      1090      1100      1110
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 288856329 1048 MDLERAKRKLEgdlklaqesIMDLENDKQQSEEKLKKKDFETSQLLSKIEDEQSL----GAQLQKKIKELQ 1114
Cdd:COG5022  1009 GALQESTKQLK---------ELPVEVAELQSASKIISSESTELSILKPLQKLKGLllleNNQLQARYKALK 1070
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
848-1925 4.49e-162

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 526.67  E-value: 4.49e-162
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   848 EKELATMKEDFVKCKEDLAKAEAKKKELEEKMVALLQEKNDLQLAVASESENLSDAEERCEGLIKSKIQLEAKLKETTER 927
Cdd:pfam01576    4 EEEMQAKEEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLQAETELCAEAEEMRARLAARKQELEEILHELESR 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   928 LEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAAQDESIGKLTKEKKALQEAHQQ 1007
Cdd:pfam01576   84 LEEEEERSQQLQNEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLLEDQNSKLSKERKLLEERISE 163
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1008 TLDDLQAEEDKVNTLTKSKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDLENDKQQSEEKLKKKDF 1087
Cdd:pfam01576  164 FTSNLAEEEEKAKSLSKLKNKHEAMISDLEERLKKEEKGRQELEKAKRKLEGESTDLQEQIAELQAQIAELRAQLAKKEE 243
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1088 ETSQLLSKIEDEQSLGAQLQKKIKELQARIEELEEEIEAERAARAKVEKQRADLSRELEEISERLEEAGGATAAQIEMNK 1167
Cdd:pfam01576  244 ELQAALARLEEETAQKNNALKKIRELEAQISELQEDLESERAARNKAEKQRRDLGEELEALKTELEDTLDTTAAQQELRS 323
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1168 KREAEFQKLRRDLEESTLQHEATAAALRKKQADSVAELGEQIDNLQRVKQKLEKEKSEYKMEIDDLSSNMEAVAKAKANL 1247
Cdd:pfam01576  324 KREQEVTELKKALEEETRSHEAQLQEMRQKHTQALEELTEQLEQAKRNKANLEKAKQALESENAELQAELRTLQQAKQDS 403
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1248 EKMCRTLEDQLSEIKSKNDENLRQINDLSAQRARLQTENGEFGRQLEEKEALVSQLTRGKQAFTQQIEELKRQIEEEVKA 1327
Cdd:pfam01576  404 EHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDVSSLESQLQDTQELLQEETRQ 483
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1328 KNALAHAVQSARHDCDLLREQFEEEQEAKAELQRGMSKANSEVAQWRTKYETDAiQRTEELEESKKKLAQRLQEAEEQIE 1407
Cdd:pfam01576  484 KLNLSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLEEDA-GTLEALEEGKKRLQRELEALTQQLE 562
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1408 AVNSKCASLEKTKQRLQGEVEDLMIDVERANALAANLDKKQRNFDKVLAEWKQKYEEGQAELEGAQKEARSLSTELFKMK 1487
Cdd:pfam01576  563 EKAAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNLEKKQKKFDQMLAEEKAISARYAEERDRAEAEAREKETRALSLA 642
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1488 NSYEETLDQLETLKRENKNLQQEISDLTEQLGETGKSIHELEKSKKAVETEKAEIQTALEEAEGTLEHEESKILRVQLEL 1567
Cdd:pfam01576  643 RALEEALEAKEELERTNKQLRAEMEDLVSSKDDVGKNVHELERSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNM 722
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1568 NQVKSEIDRKLAEKDEEIEQIKRNSQRITDSMQSTLDSEVRSRNDALRIKKKMEGDLNEMEIQLSHANRQAAEAQKQLRN 1647
Cdd:pfam01576  723 QALKAQFERDLQARDEQGEEKRRQLVKQVRELEAELEDERKQRAQAVAAKKKLELDLKELEAQIDAANKGREEAVKQLKK 802
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1648 VQAQLKDAQLHLDDAVRGQEDMKEQVAMVERRNTLMQSEIEELRAALEQTERGRKVAEQELVDASERVGLLHSQNTSLLN 1727
Cdd:pfam01576  803 LQAQMKDLQRELEEARASRDEILAQSKESEKKLKNLEAELLQLQEDLAASERARRQAQQERDELADEIASGASGKSALQD 882
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1728 TKKKLEADLVQIQSEVEDTVQEARNAEDKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEVTVKDLQHRLDEAENLAM 1807
Cdd:pfam01576  883 EKRRLEARIAQLEEELEEEQSNTELLNDRLRKSTLQVEQLTTELAAERSTSQKSESARQQLERQNKELKAKLQEMEGTVK 962
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1808 KGGKKQLQKLESRVRELESEVEAEQRRGADAVKGVRKYERRVKELTYQTEEDKKNVNRLQDLVDKLQLKVKAYKRQSEEA 1887
Cdd:pfam01576  963 SKFKSSIAALEAKIAQLEEQLEQESRERQAANKLVRRTEKKLKEVLLQVEDERRHADQYKDQAEKGNSRMKQLKRQLEEA 1042
                         1050      1060      1070
                   ....*....|....*....|....*....|....*...
gi 288856329  1888 EEQANSHLSKLRKVQHELEEAEERADIAESQVNKLRAK 1925
Cdd:pfam01576 1043 EEEASRANAARRKLQRELDDATESNESMNREVSTLKSK 1080
PTZ00014 PTZ00014
myosin-A; Provisional
56-827 6.92e-132

myosin-A; Provisional


Pssm-ID: 240229 [Multi-domain]  Cd Length: 821  Bit Score: 434.46  E-value: 6.92e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   56 DGGKVTVITLD--TKEEKVVKEDDV----HPMNPPKFDkieDMAMMTHLNEPSVLYNLKERYAAWMIYTYSGLFCATVNP 129
Cdd:PTZ00014   62 TGEKLTLKQIDppTNSTFEVKPEHAfnanSQIDPMTYG---DIGLLPHTNIPCVLDFLKHRYLKNQIYTTADPLLVAINP 138
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  130 YKWLPVYDAEVVAAYR-GKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLITGESGAGKTVNTKRVIQYFATvavqgpekk 208
Cdd:PTZ00014  139 FKDLGNTTNDWIRRYRdAKDSDKLPPHVFTTARRALENLHGVKKSQTIIVSGESGAGKTEATKQIMRYFAS--------- 209
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  209 keQASGKMQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTSGKLASADIETYLLEKSRVTFQLPDERGYH 288
Cdd:PTZ00014  210 --SKSGNMDLKIQNAIMAANPVLEAFGNAKTIRNNNSSRFGRFMQLQLGEEGGIRYGSIVAFLLEKSRVVTQEDDERSYH 287
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  289 IFYQMMTNHKPELIE-MTLITTNPYDF--PMCsqgqITVASIDDKEELVATDTAIDILGFNNEEKMGIYKFTGAVLHHGN 365
Cdd:PTZ00014  288 IFYQLLKGANDEMKEkYKLKSLEEYKYinPKC----LDVPGIDDVKDFEEVMESFDSMGLSESQIEDIFSILSGVLLLGN 363
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  366 MKFKQKQREEQAE-----PDGTEEADKIGYLLGLNSADMLKALCYPRVKVGNEFVTKGQTVPQVYNSVSALSKSIYERMF 440
Cdd:PTZ00014  364 VEIEGKEEGGLTDaaaisDESLEVFNEACELLFLDYESLKKELTVKVTYAGNQKIEGPWSKDESEMLKDSLSKAVYEKLF 443
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  441 LWMVVRINQMLDTKQQRNFFIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIVWEFIDFGMD 520
Cdd:PTZ00014  444 LWIIRNLNATIEPPGGFKVFIGMLDIFGFEVFKNNSLEQLFINITNEMLQKNFVDIVFERESKLYKDEGISTEELEYTSN 523
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  521 LAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQhLGKCNAFqkpKPAKGKAEAHFSLVHYAGTVDYNISGWLDK 600
Cdd:PTZ00014  524 ESVIDLLCGKGKSVLSILEDQCLAPGGTDEKFVSSCNTN-LKNNPKY---KPAKVDSNKNFVIKHTIGDIQYCASGFLFK 599
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  601 NKDPLNESVVQLYQKSSVKLLATLYPPVVEETGGGKKGgkkkggsmQTVSSQFRENLGKLMTNLRSTHPHFVRCLIPNES 680
Cdd:PTZ00014  600 NKDVLRPELVEVVKASPNPLVRDLFEGVEVEKGKLAKG--------QLIGSQFLNQLDSLMSLINSTEPHFIRCIKPNEN 671
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  681 KTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASVIpEGQFIDNKKASEKLLGSIDVNHDEYRF 760
Cdd:PTZ00014  672 KKPLDWNSSKVLIQLHSLSILEALQLRQLGFSYRRTFAEFLSQFKYLDLAVS-NDSSLDPKEKAEKLLERSGLPKDSYAI 750
                         730       740       750       760       770       780       790
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  761 GHTKVFFKAGLLGTLEEMRDEKLAS---LVTMTQALCRAYLMRRefvKMMERRDAIYTIQYNVRSFMNVK 827
Cdd:PTZ00014  751 GKTMVFLKKDAAKELTQIQREKLAAwepLVSVLEALILKIKKKR---KVRKNIKSLVRIQAHLRRHLVIA 817
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
1146-1928 1.13e-33

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 142.50  E-value: 1.13e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1146 EEISERLEEAGGATaaqiemnkkreaefqKLRRDLEESTLQHEATAAALrKKQADSVAELGEQIDNLQRVKQKLEK---- 1221
Cdd:TIGR02168  155 EERRAIFEEAAGIS---------------KYKERRKETERKLERTRENL-DRLEDILNELERQLKSLERQAEKAERykel 218
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1222 -------EKSEYKMEIDDLSSNMEAVAKAKANLEKMCRTLEDQLSEIKSKNDENLRQINDLSAQRARLQTENGEFGRQLE 1294
Cdd:TIGR02168  219 kaelrelELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEIS 298
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1295 EKEALV-------SQLTRGKQAFTQQIEELKRQIEEEVKAKNALAHAVQSARHDCDLLREQFEEEQEAKAELQRGMSKAN 1367
Cdd:TIGR02168  299 RLEQQKqilrerlANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELE 378
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1368 SEVAQWRTKYEtdaiqrteELEESKKKLAQRLQEAEEQIEavnskcaSLEKTKQRLQGEVEDLMIDVERAN--ALAANLD 1445
Cdd:TIGR02168  379 EQLETLRSKVA--------QLELQIASLNNEIERLEARLE-------RLEDRRERLQQEIEELLKKLEEAElkELQAELE 443
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1446 KKqrnfDKVLAEWKQKYEEGQAELEGAQKEARSLSTELFKMKNSYEET---LDQLETLKRENKNLQQEI-------SDLT 1515
Cdd:TIGR02168  444 EL----EEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLqarLDSLERLQENLEGFSEGVkallknqSGLS 519
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1516 EQLGETGKSIHELEKSKKAVETEKAEIQTAL-----EEAEGTLEH-EESKILRVQ-LELNQVKseiDRKLAEKDEEIEQI 1588
Cdd:TIGR02168  520 GILGVLSELISVDEGYEAAIEAALGGRLQAVvvenlNAAKKAIAFlKQNELGRVTfLPLDSIK---GTEIQGNDREILKN 596
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1589 KRNSQRITDSMQSTldsevrsrndALRIKKKMEGDLNEMEI--QLSHANRQAAEAQKQLRNVQaqlKDAQLHLDDAVRGQ 1666
Cdd:TIGR02168  597 IEGFLGVAKDLVKF----------DPKLRKALSYLLGGVLVvdDLDNALELAKKLRPGYRIVT---LDGDLVRPGGVITG 663
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1667 EDMKEQVAMVERRNtlmqsEIEELRAALEQTERGRKVAEQELVDASERVGLLHSQNTSLLNTKKKLEADLVQIQSEVEDT 1746
Cdd:TIGR02168  664 GSAKTNSSILERRR-----EIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARL 738
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1747 VQEARNAEDKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEVTVKDLQHRLDEAENlamkggkkQLQKLESRVRELES 1826
Cdd:TIGR02168  739 EAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKE--------ELKALREALDELRA 810
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1827 EVEAEQRRGADAVKGVRKYERRVKELTYQTEEDKKNVNRLQDLVDKLQLKVKAYKRQSEEAEEQANSHLSKLRKVQHELE 1906
Cdd:TIGR02168  811 ELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALA 890
                          810       820
                   ....*....|....*....|..
gi 288856329  1907 EAEERADIAESQVNKLRAKSRD 1928
Cdd:TIGR02168  891 LLRSELEELSEELRELESKRSE 912
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
1141-1733 8.38e-24

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 110.03  E-value: 8.38e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1141 LSRELEEISERLEEAGGATAAQIEMNKKREAEFQKLRRDLEESTLQHEATAAALRKKQADsVAELGEQIDNLQRVKQKLE 1220
Cdd:COG1196   230 LLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAE-EYELLAELARLEQDIARLE 308
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1221 KEKSEYKMEIDDLSSNMEAVAKAKANLEKMCRTLEDQLSEIKSKNDENLRQINDLSAQRARLQTENGEFGRQLEEKEALV 1300
Cdd:COG1196   309 ERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEEL 388
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1301 SQLTRGKQAFTQQIEELKRQIEEEVKAKNALAHAVQSarhdcdlLREQFEEEQEAKAELQRGMSKANSEVAQWRTKYETD 1380
Cdd:COG1196   389 LEALRAAAELAAQLEELEEAEEALLERLERLEEELEE-------LEEALAELEEEEEEEEEALEEAAEEEAELEEEEEAL 461
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1381 AIQRTEELEESKKKLAQRLQEAEEQIEAvnskcASLEKTKQRLQGEVEDLMIDVERANALAANLDKKQRnfDKVLAEWKQ 1460
Cdd:COG1196   462 LELLAELLEEAALLEAALAELLEELAEA-----AARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGA--VAVLIGVEA 534
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1461 KYEEGQAELEGAQKEARSLST--------ELFKMKNSYEETLDQLETLKREN--KNLQQEISDLTEQLGETGKSIHELEK 1530
Cdd:COG1196   535 AYEAALEAALAAALQNIVVEDdevaaaaiEYLKAAKAGRATFLPLDKIRARAalAAALARGAIGAAVDLVASDLREADAR 614
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1531 SKKAVETEKAEIQTALEEAEG-----TLEHEESKILRVQLELNQVKSEIDRKLAEKDEEIEQIKRNSQRITDSMQSTLDS 1605
Cdd:COG1196   615 YYVLGDTLLGRTLVAARLEAAlrravTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELE 694
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1606 EVRSRNDALRIKKKMEGDLNEMEIQLSHANRQAAEAQKQLRNVQAQLKDAQLHLDDAVRGQEDMKEQVAMVERRntlmqs 1685
Cdd:COG1196   695 LEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERE------ 768
                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|.
gi 288856329 1686 eIEELRAALEQTErgrKV---AEQELVDASERVGLLHSQNTSLLNTKKKLE 1733
Cdd:COG1196   769 -LERLEREIEALG---PVnllAIEEYEELEERYDFLSEQREDLEEARETLE 815
PTZ00121 PTZ00121
MAEBL; Provisional
893-1623 1.81e-20

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 99.45  E-value: 1.81e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  893 VASESENLSDAEERCEGLIKSKIQLEAKLKETTERLEDEEEINAELTAKKRKLEDECSELKKdiddleltlaKVEKEKHA 972
Cdd:PTZ00121 1248 ERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKK----------KAEEAKKA 1317
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  973 TENKVKnlTEEMAAQDESIGKLTKEKKALQEAhqqtlddlqaeedkvntltkSKTKLEQQVDDLEGSLEQEKKLRMDLER 1052
Cdd:PTZ00121 1318 DEAKKK--AEEAKKKADAAKKKAEEAKKAAEA--------------------AKAEAEAAADEAEAAEEKAEAAEKKKEE 1375
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1053 AKRKLEGDLKLAQESIMDLENDKQQSEEKLKKKDFETSQLLSKIEDEQSLGAQLQKKIKELQARIEELEEEIEAeraara 1132
Cdd:PTZ00121 1376 AKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEA------ 1449
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1133 kveKQRADLSRELEEISERLEEAGGATAAQIEMNKKREAEfqKLRRDLEESTLQ-HEATAAALRKKQADSVAELGEQidn 1211
Cdd:PTZ00121 1450 ---KKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKAD--EAKKKAEEAKKKaDEAKKAAEAKKKADEAKKAEEA--- 1521
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1212 lqrvKQKLEKEKSEYKMEIDDLSSnmeavAKAKANLEKMCRTLEDQLSEIKSKNDENLRQindlsAQRARLQTENGEFGR 1291
Cdd:PTZ00121 1522 ----KKADEAKKAEEAKKADEAKK-----AEEKKKADELKKAEELKKAEEKKKAEEAKKA-----EEDKNMALRKAEEAK 1587
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1292 QLEEKEaLVSQLTRGKQAFTQQIEELKRQIEEEVKAKNalAHAVQSARHDCDLLREQFEEEQEAKAELQRGMSKANSEVA 1371
Cdd:PTZ00121 1588 KAEEAR-IEEVMKLYEEEKKMKAEEAKKAEEAKIKAEE--LKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAA 1664
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1372 QWRTKYETDAiQRTEEL----EESKKKLAQRLQEAEE--QIEAVNSKCASLEKTKQRLQGEVEDLMIDVERAnalaanld 1445
Cdd:PTZ00121 1665 EEAKKAEEDK-KKAEEAkkaeEDEKKAAEALKKEAEEakKAEELKKKEAEEKKKAEELKKAEEENKIKAEEA-------- 1735
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1446 KKQRNFDKVLAEWKQKYEEGQAELEGAQKEARSLSTELFKMKNSYEEtldqlETLKRENKNLQQEISDLTEQLGETGKSI 1525
Cdd:PTZ00121 1736 KKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIE-----EELDEEDEKRRMEVDKKIKDIFDNFANI 1810
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1526 HELEKSKKAV-----ETEKAEIQTALEEAEGTLEhEESKILRVQLELNQVKSEIDRKLA----EKD------EEIEQIKR 1590
Cdd:PTZ00121 1811 IEGGKEGNLVindskEMEDSAIKEVADSKNMQLE-EADAFEKHKFNKNNENGEDGNKEAdfnkEKDlkeddeEEIEEADE 1889
                         730       740       750
                  ....*....|....*....|....*....|...
gi 288856329 1591 NSQRITDSMQSTLDSEVRSRNDALRIKKKMEGD 1623
Cdd:PTZ00121 1890 IEKIDKDDIEREIPNNNMAGKNNDIIDDKLDKD 1922
Myosin_N pfam02736
Myosin N-terminal SH3-like domain; This domain has an SH3-like fold. It is found at the ...
33-78 1.39e-11

Myosin N-terminal SH3-like domain; This domain has an SH3-like fold. It is found at the N-terminus of many but not all myosins. The function of this domain is unknown.


Pssm-ID: 460670  Cd Length: 45  Bit Score: 60.91  E-value: 1.39e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 288856329    33 DAKTACYVVDDKELYVKGTIKSKDGGKVTVITlDTKEEKVVKEDDV 78
Cdd:pfam02736    1 DAKKLVWVPDPKEGFVKGEIKEEEGDKVTVET-EDGKTVTVKKDDV 45
MARTX_Nterm NF012221
MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model ...
1355-1649 3.62e-08

MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model describes the N-terminal 1900 amino acids of MARTX family multifunctional-autoprocessing repeats-in-toxin holotoxins, which contain both repeat regions that facilitate their entry into eukaryotic target cells, and multiple effector domains.


Pssm-ID: 467957 [Multi-domain]  Cd Length: 1848  Bit Score: 59.08  E-value: 3.62e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1355 AKAELQRGMSKANSEVAQwrTKYETDAIQRTEELEESKKKLAQrlqEAEEQIEAVNSKCASLEKTKQrlqgevedlmidv 1434
Cdd:NF012221 1536 ATSESSQQADAVSKHAKQ--DDAAQNALADKERAEADRQRLEQ---EKQQQLAAISGSQSQLESTDQ------------- 1597
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1435 eraNALAANldkkqrnfdkvlaewkqkyeeGQAELEGAQKEARSLSTELFKMKnsyeETLDQLETLKRENKNLQQE---- 1510
Cdd:NF012221 1598 ---NALETN---------------------GQAQRDAILEESRAVTKELTTLA----QGLDALDSQATYAGESGDQwrnp 1649
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1511 -----ISDLTEQLGETGKSIHE-LEKSKKAVETEKAEIQTALEEAEGTLEHEESKILRVQLELNQVKSEIDRKlaeKDEE 1584
Cdd:NF012221 1650 fagglLDRVQEQLDDAKKISGKqLADAKQRHVDNQQKVKDAVAKSEAGVAQGEQNQANAEQDIDDAKADAEKR---KDDA 1726
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 288856329 1585 IEQIKRNSQRITDSMQSTLDSEVRSRNDAlrikkkmegdlnemeiqlSHANRQAAEAQKQLRNVQ 1649
Cdd:NF012221 1727 LAKQNEAQQAESDANAAANDAQSRGEQDA------------------SAAENKANQAQADAKGAK 1773
EcCorA_ZntB-like cd12821
Escherichia coli CorA-Salmonella typhimurium ZntB_like family; A family of the MIT superfamily ...
1297-1409 4.03e-04

Escherichia coli CorA-Salmonella typhimurium ZntB_like family; A family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of this family are found in all three kingdoms of life. It is a functionally diverse family, including the Mg2+ transporters Escherichia coli and Salmonella typhimurium CorAs (which can also transport Co2+, and Ni2+ ), and the Zn2+ transporter Salmonella typhimurium ZntB which mediates the efflux of Zn2+ (and Cd2+). It also includes two Saccharomyces cerevisiae members: the inner membrane Mg2+ transporters Mfm1p/Lpe10p, and Mrs2p, and a family of Arabidopsis thaliana members (AtMGTs) some of which are localized to distinct tissues, and not all of which can transport Mg2+. Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213355 [Multi-domain]  Cd Length: 285  Bit Score: 44.62  E-value: 4.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1297 EALVSQLTRGKQAFTQQIEELKRQIEEEVKAKnALAHAVqSARHDCDLLREQFEEEQEAKAELQRGMSKANSEvaqwrTK 1376
Cdd:cd12821   110 GAIIKALLTGIDQFEEKLEELEWDLLEGNNAI-KLDRIL-ELRRELLRLTNLIEPQQEVLMALQEAFAELLFS-----ED 182
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 288856329 1377 YET--DAIQRTEELEESKKKLAQRLQEAEEQIEAV 1409
Cdd:cd12821   183 EEElrRTLDRIERLLQLIEEYEQELDTLQDIEEVV 217
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
1298-1594 5.13e-04

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 45.00  E-value: 5.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1298 ALVSQLTRGKQAFTQQIEELKRQIEEEV--KAKNALAHAVQSARHDCDLLREQFEE------EQEAKAELQRGMSKANSE 1369
Cdd:NF033838   88 ALNKKLSDIKTEYLYELNVLKEKSEAELtsKTKKELDAAFEQFKKDTLEPGKKVAEatkkveEAEKKAKDQKEEDRRNYP 167
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1370 VAQWRT----KYETDAIQRTEELEESKKKL-----AQRLQEAEEQIEAVNSKCASLEKTK-QRLQGEVE-DLMIDVERAN 1438
Cdd:NF033838  168 TNTYKTleleIAESDVEVKKAELELVKEEAkeprdEEKIKQAKAKVESKKAEATRLEKIKtDREKAEEEaKRRADAKLKE 247
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1439 ALAANLDKKQRnfDKVLAEWKQKYEEGQAELEGAQKEARSLSTELfkmknsYEETLDQlETLKRENKNLQQEISdlTEQL 1518
Cdd:NF033838  248 AVEKNVATSEQ--DKPKRRAKRGVLGEPATPDKKENDAKSSDSSV------GEETLPS-PSLKPEKKVAEAEKK--VEEA 316
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1519 GETGKSIHELEK------SKKAVETEKAEIQTALEEAEGTLEHEESKILRVQLELNQVKSEIDRKLAEKdEEIEQIKRNS 1592
Cdd:NF033838  317 KKKAKDQKEEDRrnyptnTYKTLELEIAESDVKVKEAELELVKEEAKEPRNEEKIKQAKAKVESKKAEA-TRLEKIKTDR 395

                  ..
gi 288856329 1593 QR 1594
Cdd:NF033838  396 KK 397
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
1420-1573 1.10e-03

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 43.47  E-value: 1.10e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   1420 KQRLQGEVEDLMIDVERANALAANLDKKQRNFDKVLAEWKQKYEEGQAELEGAQKEARSL----STELFKMKNsyeetld 1495
Cdd:smart00787  139 MKLLEGLKEGLDENLEGLKEDYKLLMKELELLNSIKPKLRDRKDALEEELRQLKQLEDELedcdPTELDRAKE------- 211
                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 288856329   1496 QLETLKRENKNLQQEISDLTEQLGETGKSIHELEKSKKAVETEKAEIQTALEEAEGtleHEESKILRVQLELNQVKSE 1573
Cdd:smart00787  212 KLKKLLQEIMIKVKKLEELEEELQELESKIEDLTNKKSELNTEIAEAEKKLEQCRG---FTFKEIEKLKEQLKLLQSL 286
growth_prot_Scy NF041483
polarized growth protein Scy;
1002-1913 4.15e-03

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 42.12  E-value: 4.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1002 QEAHQQTLDDLQAEEDKVNTLTKSKTKLEQQVDDLEGSLEQekkLRMDLERAKRklegdlKLAQESIMDLENDKQQSEEK 1081
Cdd:NF041483    7 QESHRADDDHLSRFEAEMDRLKTEREKAVQHAEDLGYQVEV---LRAKLHEARR------SLASRPAYDGADIGYQAEQL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1082 LKKKDFETSQLLSKIEDE-QSLGAQLQKKIKElqarieELEEEIEAERAARAKVEKQRADLSRELEEISERLEEAGGATA 1160
Cdd:NF041483   78 LRNAQIQADQLRADAERElRDARAQTQRILQE------HAEHQARLQAELHTEAVQRRQQLDQELAERRQTVESHVNENV 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1161 AQIEMNKKREAefQKLRRDLEESTLQHEATAAALRkKQADSVAElgeqidnlqRVKQKLEKEKSEYKMEIDDLssnmeaV 1240
Cdd:NF041483  152 AWAEQLRARTE--SQARRLLDESRAEAEQALAAAR-AEAERLAE---------EARQRLGSEAESARAEAEAI------L 213
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1241 AKAKANLEKMCRTLEDQLSEIKSkNDENLRQINDLSAQRARLQTenGEFGRQLEEKEALVSQLTRGKQAftqQIEELKRQ 1320
Cdd:NF041483  214 RRARKDAERLLNAASTQAQEATD-HAEQLRSSTAAESDQARRQA--AELSRAAEQRMQEAEEALREARA---EAEKVVAE 287
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1321 IEEEVKAKNALAHAVQSAR------HDCDLLREQFEEEQEAKAELQRGMSKANSEVAQWRTKYETDAiqRTEELEESKKK 1394
Cdd:NF041483  288 AKEAAAKQLASAESANEQRtrtakeEIARLVGEATKEAEALKAEAEQALADARAEAEKLVAEAAEKA--RTVAAEDTAAQ 365
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1395 LAQRLQEAEEQIEAVN------SKCASLEKTKQRLQGEVEdlmidVERANALAANLDkkqrnfDKVLAEWKQKYEEGQAE 1468
Cdd:NF041483  366 LAKAARTAEEVLTKASedakatTRAAAEEAERIRREAEAE-----ADRLRGEAADQA------EQLKGAAKDDTKEYRAK 434
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1469 LEGAQKEARSLSTELFKMKnsyEETLDQLETLKRENKNlqqeisDLTEQLGETGKSIHELEKSKKAVETEKAEIQTALEE 1548
Cdd:NF041483  435 TVELQEEARRLRGEAEQLR---AEAVAEGERIRGEARR------EAVQQIEEAARTAEELLTKAKADADELRSTATAESE 505
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1549 AEGTLEHEESKILRVQLE--LNQVKSEIDRKLAEKDEEIEQIKRNSQRitdsmqstldSEVRSRNDALRikkkmegdlne 1626
Cdd:NF041483  506 RVRTEAIERATTLRRQAEetLERTRAEAERLRAEAEEQAEEVRAAAER----------AARELREETER----------- 564
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1627 meiqlSHANRQAAEAqkqlrnvqaqlkdaqlhlDDAVRGQEDMKEQVAMVERRNTLMQSEIEELR-AALEQTERGRkvae 1705
Cdd:NF041483  565 -----AIAARQAEAA------------------EELTRLHTEAEERLTAAEEALADARAEAERIRrEAAEETERLR---- 617
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1706 qelVDASERVGLLHSQntsllntkkkLEADLVQIQSEVEDTVQEAR-NAEDKAKKAITDAAMMAEELKKE-QDTS----- 1778
Cdd:NF041483  618 ---TEAAERIRTLQAQ----------AEQEAERLRTEAAADASAARaEGENVAVRLRSEAAAEAERLKSEaQESAdrvra 684
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1779 ---AHLERM----KKNLEVTVKDLQHRLDEAENLaMKGGKKQLQKLESRVRELESEVEAEQRR-----GADAVKGVRKYE 1846
Cdd:NF041483  685 eaaAAAERVgteaAEALAAAQEEAARRRREAEET-LGSARAEADQERERAREQSEELLASARKrveeaQAEAQRLVEEAD 763
                         890       900       910       920       930       940       950
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 288856329 1847 RRVKELTYQTEEDKKNVnrlQDLVDKLQlkvkaykrqseeaeEQANSHLSKLRK-VQHELE----EAEERAD 1913
Cdd:NF041483  764 RRATELVSAAEQTAQQV---RDSVAGLQ--------------EQAEEEIAGLRSaAEHAAErtrtEAQEEAD 818
 
Name Accession Description Interval E-value
MYSc_class_II cd01377
class II myosins, motor domain; Myosin motor domain in class II myosins. Class II myosins, ...
101-768 0e+00

class II myosins, motor domain; Myosin motor domain in class II myosins. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. Thus, myosin II has two heads. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276951 [Multi-domain]  Cd Length: 662  Bit Score: 1279.71  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  101 PSVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLITG 180
Cdd:cd01377     1 ASVLHNLRERYYSDLIYTYSGLFCVAVNPYKRLPIYTEEVIDKYKGKRREEMPPHIFAIADNAYRNMLQDRENQSILITG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  181 ESGAGKTVNTKRVIQYFATVAVQGPEKKKEqasGKMQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTSG 260
Cdd:cd01377    81 ESGAGKTENTKKVIQYLASVAASSKKKKES---GKKKGTLEDQILQANPILEAFGNAKTVRNNNSSRFGKFIRIHFGSTG 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  261 KLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPELIEMTLITTNPYDFPMCSQGQITVASIDDKEELVATDTAI 340
Cdd:cd01377   158 KIAGADIETYLLEKSRVVRQAKGERNYHIFYQLLSGADPELKEKLLLTGDPSYYFFLSQGELTIDGVDDAEEFKLTDEAF 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  341 DILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQREEQAEPDGTEEADKIGYLLGLNSADMLKALCYPRVKVGNEFVTKGQT 420
Cdd:cd01377   238 DILGFSEEEKMSIFKIVAAILHLGNIKFKQRRREEQAELDGTEEADKAAHLLGVNSSDLLKALLKPRIKVGREWVTKGQN 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  421 VPQVYNSVSALSKSIYERMFLWMVVRINQMLDTKQQRNFFIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFNHHMFVL 500
Cdd:cd01377   318 KEQVVFSVGALAKALYERLFLWLVKRINKTLDTKSKRQYFIGVLDIAGFEIFEFNSFEQLCINYTNEKLQQFFNHHMFVL 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  501 EQEEYKKEGIVWEFIDFGMDLAACIELIEKP-LGIFSILEEECMFPKATDTSFKNKLYDQHLGKCNAFQKPKPakGKAEA 579
Cdd:cd01377   398 EQEEYKKEGIEWTFIDFGLDLQPTIDLIEKPnMGILSILDEECVFPKATDKTFVEKLYSNHLGKSKNFKKPKP--KKSEA 475
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  580 HFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYPPVVEETgGGKKGGKKKGGSMQTVSSQFRENLGK 659
Cdd:cd01377   476 HFILKHYAGDVEYNIDGWLEKNKDPLNENVVALLKKSSDPLVASLFKDYEESG-GGGGKKKKKGGSFRTVSQLHKEQLNK 554
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  660 LMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASVIPEGQFiD 739
Cdd:cd01377   555 LMTTLRSTHPHFVRCIIPNEEKKPGKIDAPLVLHQLRCNGVLEGIRICRKGFPNRIIFAEFKQRYSILAPNAIPKGFD-D 633
                         650       660
                  ....*....|....*....|....*....
gi 288856329  740 NKKASEKLLGSIDVNHDEYRFGHTKVFFK 768
Cdd:cd01377   634 GKAACEKILKALQLDPELYRIGNTKVFFK 662
MYSc_Myh3 cd14913
class II myosin heavy chain 3, motor domain; Myosin motor domain of fetal skeletal muscle ...
101-768 0e+00

class II myosin heavy chain 3, motor domain; Myosin motor domain of fetal skeletal muscle myosin heavy chain 3 (MYHC-EMB, MYHSE1, HEMHC, SMHCE) in tetrapods including mammals, lizards, and frogs. This gene is a member of the MYH family and encodes a protein with an IQ domain and a myosin head-like domain. Mutations in this gene have been associated with two congenital contracture (arthrogryposis) syndromes, Freeman-Sheldon syndrome and Sheldon-Hall syndrome. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276878 [Multi-domain]  Cd Length: 668  Bit Score: 1229.92  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  101 PSVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLITG 180
Cdd:cd14913     1 PAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  181 ESGAGKTVNTKRVIQYFATVAVQGPEKKKEQAsgKMQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTSG 260
Cdd:cd14913    81 ESGAGKTVNTKRVIQYFATIAATGDLAKKKDS--KMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTG 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  261 KLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPELIEMTLITTNPYDFPMCSQGQITVASIDDKEELVATDTAI 340
Cdd:cd14913   159 KLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPYDYPFISQGEILVASIDDAEELLATDSAI 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  341 DILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQREEQAEPDGTEEADKIGYLLGLNSADMLKALCYPRVKVGNEFVTKGQT 420
Cdd:cd14913   239 DILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQT 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  421 VPQVYNSVSALSKSIYERMFLWMVVRINQMLDTKQQRNFFIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFNHHMFVL 500
Cdd:cd14913   319 VDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVL 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  501 EQEEYKKEGIVWEFIDFGMDLAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQHLGKCNAFQKPKPAKGKAEAH 580
Cdd:cd14913   399 EQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKVVKGRAEAH 478
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  581 FSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYP--PVVEETGGGKKGGKKKGGSMQTVSSQFRENLG 658
Cdd:cd14913   479 FSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYAtfATADADSGKKKVAKKKGSSFQTVSALFRENLN 558
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  659 KLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASVIPEGQFI 738
Cdd:cd14913   559 KLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAIPEGQFI 638
                         650       660       670
                  ....*....|....*....|....*....|
gi 288856329  739 DNKKASEKLLGSIDVNHDEYRFGHTKVFFK 768
Cdd:cd14913   639 DSKKACEKLLASIDIDHTQYKFGHTKVFFK 668
MYSc_Myh13 cd14923
class II myosin heavy chain 13, motor domain; Myosin motor domain of skeletal muscle myosin ...
101-768 0e+00

class II myosin heavy chain 13, motor domain; Myosin motor domain of skeletal muscle myosin heavy chain 13 (also called MyHC-eo) in mammals, chicken, and green anole. Myh13 is a myosin whose expression is restricted primarily to the extrinsic eye muscles which are specialized for function in eye movement. Class II myosins, also called conventional myosins, are the myosin type responsible for producing muscle contraction in muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276887 [Multi-domain]  Cd Length: 671  Bit Score: 1156.36  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  101 PSVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLITG 180
Cdd:cd14923     1 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRDNQSILITG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  181 ESGAGKTVNTKRVIQYFATVAVQGpEKKKEQASGKMQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTSG 260
Cdd:cd14923    81 ESGAGKTVNTKRVIQYFATIAVTG-DKKKEQQPGKMQGTLEDQIIQANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATG 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  261 KLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPELIEMTLITTNPYDFPMCSQGQITVASIDDKEELVATDTAI 340
Cdd:cd14923   160 KLASADIETYLLEKSRVTFQLSSERSYHIFYQIMSNKKPELIDLLLISTNPFDFPFVSQGEVTVASIDDSEELLATDNAI 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  341 DILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQREEQAEPDGTEEADKIGYLLGLNSADMLKALCYPRVKVGNEFVTKGQT 420
Cdd:cd14923   240 DILGFSSEEKVGIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAGYLMGLNSAEMLKGLCCPRVKVGNEYVTKGQN 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  421 VPQVYNSVSALSKSIYERMFLWMVVRINQMLDTKQQRNFFIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFNHHMFVL 500
Cdd:cd14923   320 VQQVTNSVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVL 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  501 EQEEYKKEGIVWEFIDFGMDLAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQHLGKCNAFQKPKPAKGKAEAH 580
Cdd:cd14923   400 EQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKPAKGKAEAH 479
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  581 FSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYPPVVE----ETGGGKKGGKKKGGSMQTVSSQFREN 656
Cdd:cd14923   480 FSLVHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSSLKLLSFLFSNYAGaeagDSGGSKKGGKKKGSSFQTVSAVFREN 559
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  657 LGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASVIPEGQ 736
Cdd:cd14923   560 LNKLMTNLRSTHPHFVRCLIPNETKTPGVMDHYLVMHQLRCNGVLEGIRICRKGFPSRILYADFKQRYRILNASAIPEGQ 639
                         650       660       670
                  ....*....|....*....|....*....|..
gi 288856329  737 FIDNKKASEKLLGSIDVNHDEYRFGHTKVFFK 768
Cdd:cd14923   640 FIDSKNASEKLLNSIDVDREQYRFGHTKVFFK 671
MYSc_Myh4 cd14915
class II myosin heavy chain 4, motor domain; Myosin motor domain of skeletal muscle myosin ...
101-768 0e+00

class II myosin heavy chain 4, motor domain; Myosin motor domain of skeletal muscle myosin heavy chain 4 (also called MYH2B, MyHC-2B, MyHC-IIb). Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276879 [Multi-domain]  Cd Length: 671  Bit Score: 1148.32  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  101 PSVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLITG 180
Cdd:cd14915     1 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  181 ESGAGKTVNTKRVIQYFATVAVQGPEKKKEQASGKMQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTSG 260
Cdd:cd14915    81 ESGAGKTVNTKRVIQYFATIAVTGEKKKEEAASGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  261 KLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPELIEMTLITTNPYDFPMCSQGQITVASIDDKEELVATDTAI 340
Cdd:cd14915   161 KLASADIETYLLEKSRVTFQLKAERSYHIFYQIMSNKKPELIEMLLITTNPYDFAFVSQGEITVPSIDDQEELMATDSAV 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  341 DILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQREEQAEPDGTEEADKIGYLLGLNSADMLKALCYPRVKVGNEFVTKGQT 420
Cdd:cd14915   241 DILGFSADEKVAIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLTSLNSADLLKALCYPRVKVGNEYVTKGQT 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  421 VPQVYNSVSALSKSIYERMFLWMVVRINQMLDTKQQRNFFIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFNHHMFVL 500
Cdd:cd14915   321 VQQVYNSVGALAKAIYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVL 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  501 EQEEYKKEGIVWEFIDFGMDLAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQHLGKCNAFQKPKPAKGKAEAH 580
Cdd:cd14915   401 EQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQKPKPAKGKAEAH 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  581 FSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYP---PVVEETGGGKKGGKKKGGSMQTVSSQFRENL 657
Cdd:cd14915   481 FSLVHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSGMKTLAFLFSggqTAEAEGGGGKKGGKKKGSSFQTVSALFRENL 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  658 GKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASVIPEGQF 737
Cdd:cd14915   561 NKLMTNLRSTHPHFVRCLIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEGQF 640
                         650       660       670
                  ....*....|....*....|....*....|.
gi 288856329  738 IDNKKASEKLLGSIDVNHDEYRFGHTKVFFK 768
Cdd:cd14915   641 IDSKKASEKLLGSIDIDHTQYKFGHTKVFFK 671
MYSc_Myh1_mammals cd14910
class II myosin heavy chain 1, motor domain; Myosin motor domain of type IIx skeletal muscle ...
101-768 0e+00

class II myosin heavy chain 1, motor domain; Myosin motor domain of type IIx skeletal muscle myosin heavy chain 1 (also called MYHSA1, MYHa, MyHC-2X/D, MGC133384) in mammals. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276875 [Multi-domain]  Cd Length: 671  Bit Score: 1146.78  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  101 PSVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLITG 180
Cdd:cd14910     1 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  181 ESGAGKTVNTKRVIQYFATVAVQGPEKKKEQASGKMQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTSG 260
Cdd:cd14910    81 ESGAGKTVNTKRVIQYFATIAVTGEKKKEEATSGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  261 KLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPELIEMTLITTNPYDFPMCSQGQITVASIDDKEELVATDTAI 340
Cdd:cd14910   161 KLASADIETYLLEKSRVTFQLKAERSYHIFYQIMSNKKPDLIEMLLITTNPYDYAFVSQGEITVPSIDDQEELMATDSAI 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  341 DILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQREEQAEPDGTEEADKIGYLLGLNSADMLKALCYPRVKVGNEFVTKGQT 420
Cdd:cd14910   241 EILGFTSDERVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLQNLNSADLLKALCYPRVKVGNEYVTKGQT 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  421 VPQVYNSVSALSKSIYERMFLWMVVRINQMLDTKQQRNFFIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFNHHMFVL 500
Cdd:cd14910   321 VQQVYNAVGALAKAVYDKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVL 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  501 EQEEYKKEGIVWEFIDFGMDLAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQHLGKCNAFQKPKPAKGKAEAH 580
Cdd:cd14910   401 EQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQKPKPAKGKVEAH 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  581 FSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYPPVV---EETGGGKKGGKKKGGSMQTVSSQFRENL 657
Cdd:cd14910   481 FSLIHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSSMKTLALLFSGAAaaeAEEGGGKKGGKKKGSSFQTVSALFRENL 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  658 GKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASVIPEGQF 737
Cdd:cd14910   561 NKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEGQF 640
                         650       660       670
                  ....*....|....*....|....*....|.
gi 288856329  738 IDNKKASEKLLGSIDVNHDEYRFGHTKVFFK 768
Cdd:cd14910   641 IDSKKASEKLLGSIDIDHTQYKFGHTKVFFK 671
MYSc_Myh8 cd14918
class II myosin heavy chain 8, motor domain; Myosin motor domain of perinatal skeletal muscle ...
101-768 0e+00

class II myosin heavy chain 8, motor domain; Myosin motor domain of perinatal skeletal muscle myosin heavy chain 8 (also called MyHC-peri, MyHC-pn). Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. A mutation in this gene results in trismus-pseudocamptodactyly syndrome. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276882 [Multi-domain]  Cd Length: 668  Bit Score: 1129.83  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  101 PSVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLITG 180
Cdd:cd14918     1 PGVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  181 ESGAGKTVNTKRVIQYFATVAVQGPEKKKEqaSGKMQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTSG 260
Cdd:cd14918    81 ESGAGKTVNTKRVIQYFATIAVTGEKKKEE--SGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTG 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  261 KLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPELIEMTLITTNPYDFPMCSQGQITVASIDDKEELVATDTAI 340
Cdd:cd14918   159 KLASADIETYLLEKSRVTFQLKAERSYHIFYQITSNKKPDLIEMLLITTNPYDYAFVSQGEITVPSIDDQEELMATDSAI 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  341 DILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQREEQAEPDGTEEADKIGYLLGLNSADMLKALCYPRVKVGNEFVTKGQT 420
Cdd:cd14918   239 DILGFTPEEKVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLQSLNSADLLKALCYPRVKVGNEYVTKGQT 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  421 VPQVYNSVSALSKSIYERMFLWMVVRINQMLDTKQQRNFFIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFNHHMFVL 500
Cdd:cd14918   319 VQQVYNAVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVL 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  501 EQEEYKKEGIVWEFIDFGMDLAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQHLGKCNAFQKPKPAKGKAEAH 580
Cdd:cd14918   399 EQEEYKKEGIEWTFIDFGMDLAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQHLGKSANFQKPKVVKGKAEAH 478
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  581 FSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYPPV--VEETGGGKKGGKKKGGSMQTVSSQFRENLG 658
Cdd:cd14918   479 FSLIHYAGTVDYNITGWLDKNKDPLNDTVVGLYQKSAMKTLASLFSTYasAEADSGAKKGAKKKGSSFQTVSALFRENLN 558
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  659 KLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASVIPEGQFI 738
Cdd:cd14918   559 KLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKVLNASAIPEGQFI 638
                         650       660       670
                  ....*....|....*....|....*....|
gi 288856329  739 DNKKASEKLLGSIDVNHDEYRFGHTKVFFK 768
Cdd:cd14918   639 DSKKASEKLLASIDIDHTQYKFGHTKVFFK 668
MYSc_Myh2_mammals cd14912
class II myosin heavy chain 2, motor domain; Myosin motor domain of type IIa skeletal muscle ...
101-768 0e+00

class II myosin heavy chain 2, motor domain; Myosin motor domain of type IIa skeletal muscle myosin heavy chain 2 (also called MYH2A, MYHSA2, MyHC-IIa, MYHas8, MyHC-2A) in mammals. Mutations in this gene results in inclusion body myopathy-3 and familial congenital myopathy. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276877 [Multi-domain]  Cd Length: 673  Bit Score: 1118.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  101 PSVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLITG 180
Cdd:cd14912     1 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  181 ESGAGKTVNTKRVIQYFATVAVQGPEKKKEQASGKMQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTSG 260
Cdd:cd14912    81 ESGAGKTVNTKRVIQYFATIAVTGEKKKEEITSGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  261 KLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPELIEMTLITTNPYDFPMCSQGQITVASIDDKEELVATDTAI 340
Cdd:cd14912   161 KLASADIETYLLEKSRVTFQLKAERSYHIFYQITSNKKPELIEMLLITTNPYDYPFVSQGEISVASIDDQEELMATDSAI 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  341 DILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQREEQAEPDGTEEADKIGYLLGLNSADMLKALCYPRVKVGNEFVTKGQT 420
Cdd:cd14912   241 DILGFTNEEKVSIYKLTGAVMHYGNLKFKQKQREEQAEPDGTEVADKAAYLQSLNSADLLKALCYPRVKVGNEYVTKGQT 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  421 VPQVYNSVSALSKSIYERMFLWMVVRINQMLDTKQQRNFFIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFNHHMFVL 500
Cdd:cd14912   321 VEQVTNAVGALAKAVYEKMFLWMVARINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVL 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  501 EQEEYKKEGIVWEFIDFGMDLAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQHLGKCNAFQKPKPAKGKAEAH 580
Cdd:cd14912   401 EQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSANFQKPKVVKGKAEAH 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  581 FSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYPPVVEETGG-----GKKGGKKKGGSMQTVSSQFRE 655
Cdd:cd14912   481 FSLIHYAGVVDYNITGWLDKNKDPLNETVVGLYQKSAMKTLAYLFSGAQTAEGAsagggAKKGGKKKGSSFQTVSALFRE 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  656 NLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASVIPEG 735
Cdd:cd14912   561 NLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEG 640
                         650       660       670
                  ....*....|....*....|....*....|...
gi 288856329  736 QFIDNKKASEKLLGSIDVNHDEYRFGHTKVFFK 768
Cdd:cd14912   641 QFIDSKKASEKLLASIDIDHTQYKFGHTKVFFK 673
MYSc_Myh7b cd14927
class II myosin heavy chain 7b, motor domain; Myosin motor domain of cardiac muscle, beta ...
102-768 0e+00

class II myosin heavy chain 7b, motor domain; Myosin motor domain of cardiac muscle, beta myosin heavy chain 7b (also called KIAA1512, dJ756N5.1, MYH14, MHC14). MYH7B is a slow-twitch myosin. Mutations in this gene result in one form of autosomal dominant hearing impairment. Multiple transcript variants encoding different isoforms have been found for this gene. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276953 [Multi-domain]  Cd Length: 676  Bit Score: 1112.33  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  102 SVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLITGE 181
Cdd:cd14927     2 SVLHNLRRRYSRWMIYTYSGLFCVTVNPYKWLPVYTAPVVAAYKGKRRSEAPPHIYAIADNAYNDMLRNRENQSMLITGE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  182 SGAGKTVNTKRVIQYFATVAVQG--PEKKKEQASGKMQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTS 259
Cdd:cd14927    82 SGAGKTVNTKRVIQYFAIVAALGdgPGKKAQFLATKTGGTLEDQIIEANPAMEAFGNAKTLRNDNSSRFGKFIRIHFGPT 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  260 GKLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPELIEMTLITTNPYDFPMCSQGQITVASIDDKEELVATDTA 339
Cdd:cd14927   162 GKLASADIDIYLLEKSRVIFQQPGERSYHIYYQILSGKKPELQDMLLVSMNPYDYHFCSQGVTTVDNMDDGEELMATDHA 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  340 IDILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQREEQAEPDGTEEADKIGYLLGLNSADMLKALCYPRVKVGNEFVTKGQ 419
Cdd:cd14927   242 MDILGFSPDEKYGCYKIVGAIMHFGNMKFKQKQREEQAEADGTESADKAAYLMGVSSADLLKGLLHPRVKVGNEYVTKGQ 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  420 TVPQVYNSVSALSKSIYERMFLWMVVRINQMLDTKQQRNFFIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFNHHMFV 499
Cdd:cd14927   322 SVEQVVYAVGALAKATYDRMFKWLVSRINQTLDTKLPRQFFIGVLDIAGFEIFEFNSFEQLCINFTNEKLQQFFNHHMFI 401
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  500 LEQEEYKKEGIVWEFIDFGMDLAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQHLGKCNAFQKPKP-AKGKAE 578
Cdd:cd14927   402 LEQEEYKREGIEWVFIDFGLDLQACIDLIEKPLGILSILEEECMFPKASDASFKAKLYDNHLGKSPNFQKPRPdKKRKYE 481
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  579 AHFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYPPVV-----EETGGGKKGGKKKGGSMQTVSSQF 653
Cdd:cd14927   482 AHFEVVHYAGVVPYNIVGWLDKNKDPLNETVVAIFQKSQNKLLATLYENYVgsdstEDPKSGVKEKRKKAASFQTVSQLH 561
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  654 RENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASVIP 733
Cdd:cd14927   562 KENLNKLMTNLRATQPHFVRCIIPNETKTPGVMDPFLVLHQLRCNGVLEGIRICRKGFPNRILYADFKQRYRILNPSAIP 641
                         650       660       670
                  ....*....|....*....|....*....|....*
gi 288856329  734 EGQFIDNKKASEKLLGSIDVNHDEYRFGHTKVFFK 768
Cdd:cd14927   642 DDKFVDSRKATEKLLGSLDIDHTQYQFGHTKVFFK 676
MYSc_Myh7 cd14917
class II myosin heavy chain 7, motor domain; Myosin motor domain of beta (or slow) type I ...
101-768 0e+00

class II myosin heavy chain 7, motor domain; Myosin motor domain of beta (or slow) type I cardiac muscle myosin heavy chain 7 (also called CMH1, MPD1, and CMD1S). Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. It is expressed predominantly in normal human ventrical and in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276881 [Multi-domain]  Cd Length: 668  Bit Score: 1063.18  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  101 PSVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLITG 180
Cdd:cd14917     1 PAVLYNLKERYASWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  181 ESGAGKTVNTKRVIQYFATVAVQGPEKKKEQASGKmqGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTSG 260
Cdd:cd14917    81 ESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQTPGK--GTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATG 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  261 KLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPELIEMTLITTNPYDFPMCSQGQITVASIDDKEELVATDTAI 340
Cdd:cd14917   159 KLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAF 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  341 DILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQREEQAEPDGTEEADKIGYLLGLNSADMLKALCYPRVKVGNEFVTKGQT 420
Cdd:cd14917   239 DVLGFTSEEKNSMYKLTGAIMHFGNMKFKQKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQN 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  421 VPQVYNSVSALSKSIYERMFLWMVVRINQMLDTKQQRNFFIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFNHHMFVL 500
Cdd:cd14917   319 VQQVIYATGALAKAVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVL 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  501 EQEEYKKEGIVWEFIDFGMDLAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQHLGKCNAFQKPKPAKGKAEAH 580
Cdd:cd14917   399 EQEEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSNNFQKPRNIKGKPEAH 478
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  581 FSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYPPV--VEETGGGKKGGKKKGGSMQTVSSQFRENLG 658
Cdd:cd14917   479 FSLIHYAGTVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSNLFANYagADAPIEKGKGKAKKGSSFQTVSALHRENLN 558
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  659 KLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASVIPEGQFI 738
Cdd:cd14917   559 KLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFI 638
                         650       660       670
                  ....*....|....*....|....*....|
gi 288856329  739 DNKKASEKLLGSIDVNHDEYRFGHTKVFFK 768
Cdd:cd14917   639 DSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 668
MYSc_Myh6 cd14916
class II myosin heavy chain 6, motor domain; Myosin motor domain of alpha (or fast) cardiac ...
101-768 0e+00

class II myosin heavy chain 6, motor domain; Myosin motor domain of alpha (or fast) cardiac muscle myosin heavy chain 6. Cardiac muscle myosin is a hexamer consisting of two heavy chain subunits, two light chain subunits, and two regulatory subunits. This gene encodes the alpha heavy chain subunit of cardiac myosin. Mutations in this gene cause familial hypertrophic cardiomyopathy and atrial septal defect. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276880 [Multi-domain]  Cd Length: 670  Bit Score: 1060.82  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  101 PSVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLITG 180
Cdd:cd14916     1 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  181 ESGAGKTVNTKRVIQYFATVAVQGPEKKKEQASGKmQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTSG 260
Cdd:cd14916    81 ESGAGKTVNTKRVIQYFASIAAIGDRSKKENPNAN-KGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATG 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  261 KLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPELIEMTLITTNPYDFPMCSQGQITVASIDDKEELVATDTAI 340
Cdd:cd14916   160 KLASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFVSQGEVSVASIDDSEELLATDSAF 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  341 DILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQREEQAEPDGTEEADKIGYLLGLNSADMLKALCYPRVKVGNEFVTKGQT 420
Cdd:cd14916   240 DVLGFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQS 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  421 VPQVYNSVSALSKSIYERMFLWMVVRINQMLDTKQQRNFFIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFNHHMFVL 500
Cdd:cd14916   320 VQQVYYSIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVL 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  501 EQEEYKKEGIVWEFIDFGMDLAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQHLGKCNAFQKPKPAKGKAEAH 580
Cdd:cd14916   400 EQEEYKKEGIEWEFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKASDMTFKAKLYDNHLGKSNNFQKPRNVKGKQEAH 479
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  581 FSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATL---YPPVVEETGGGKKGGKKKGGSMQTVSSQFRENL 657
Cdd:cd14916   480 FSLVHYAGTVDYNILGWLEKNKDPLNETVVGLYQKSSLKLMATLfstYASADTGDSGKGKGGKKKGSSFQTVSALHRENL 559
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  658 GKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASVIPEGQF 737
Cdd:cd14916   560 NKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQF 639
                         650       660       670
                  ....*....|....*....|....*....|.
gi 288856329  738 IDNKKASEKLLGSIDVNHDEYRFGHTKVFFK 768
Cdd:cd14916   640 IDSRKGAEKLLGSLDIDHNQYKFGHTKVFFK 670
MYSc_Myh15_mammals cd14929
class II myosin heavy chain 15, motor domain; Myosin motor domain of sarcomeric myosin heavy ...
101-768 0e+00

class II myosin heavy chain 15, motor domain; Myosin motor domain of sarcomeric myosin heavy chain 15 in mammals (also called KIAA1000) . MYH15 is a slow-twitch myosin. Myh15 is a ventricular myosin heavy chain. Myh15 is absent in embryonic and fetal muscles and is found in orbital layer of extraocular muscles at birth. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276892 [Multi-domain]  Cd Length: 662  Bit Score: 1008.74  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  101 PSVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLITG 180
Cdd:cd14929     1 ASVLHTLRRRYDHWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  181 ESGAGKTVNTKRVIQYFATVAVQGPEKKKeqasgkmQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTSG 260
Cdd:cd14929    81 ESGAGKTVNTKHIIQYFATIAAMIESKKK-------LGALEDQIMQANPVLEAFGNAKTLRNDNSSRFGKFIRMHFGARG 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  261 KLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKpELIEMTLITTNPYDFPMCSQGQITVASIDDKEELVATDTAI 340
Cdd:cd14929   154 MLSSADIDIYLLEKSRVIFQQPGERNYHIFYQILSGKK-ELRDLLLVSANPSDFHFCSCGAVAVESLDDAEELLATEQAM 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  341 DILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQREEQAEPDGTEEADKIGYLLGLNSADMLKALCYPRVKVGNEFVTKGQT 420
Cdd:cd14929   233 DILGFLPDEKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTENADKAAFLMGINSSELVKGLIHPRIKVGNEYVTRSQN 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  421 VPQVYNSVSALSKSIYERMFLWMVVRINQMLDTKQQRNFFIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFNHHMFVL 500
Cdd:cd14929   313 IEQVTYAVGALSKSIYERMFKWLVARINRVLDAKLSRQFFIGILDITGFEILDYNSLEQLCINFTNEKLQQFFNQHMFVL 392
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  501 EQEEYKKEGIVWEFIDFGMDLAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQHLGKCNAFQKPKPAKGKAEAH 580
Cdd:cd14929   393 EQEEYRKEGIDWVSIDFGLDLQACIDLIEKPMGIFSILEEECMFPKATDLTFKTKLFDNHFGKSVHFQKPKPDKKKFEAH 472
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  581 FSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYPP--VVEETGGGKKGGKKKGGSMQTVSSQFRENLG 658
Cdd:cd14929   473 FELVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENyiSTDSAIQFGEKKRKKGASFQTVASLHKENLN 552
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  659 KLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASVIPEGQFI 738
Cdd:cd14929   553 KLMTNLKSTAPHFVRCINPNVNKIPGVLDPYLVLQQLRCNGVLEGIRICREGFPNRLLYADFKQRYCILNPRTFPKSKFV 632
                         650       660       670
                  ....*....|....*....|....*....|
gi 288856329  739 DNKKASEKLLGSIDVNHDEYRFGHTKVFFK 768
Cdd:cd14929   633 SSRKAAEELLGSLEIDHTQYRFGITKVFFK 662
Myosin_head pfam00063
Myosin head (motor domain);
89-768 0e+00

Myosin head (motor domain);


Pssm-ID: 395017 [Multi-domain]  Cd Length: 674  Bit Score: 1000.64  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329    89 IEDMAMMTHLNEPSVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFML 168
Cdd:pfam00063    1 VEDMVELSYLNEPSVLHNLKKRYKSDLIYTYSGLVLVAVNPYKQLPIYSEDMIKAYRGKRRGELPPHIFAIADEAYRSML 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   169 TDRENQSVLITGESGAGKTVNTKRVIQYFATVAVQGPEKKKeqasgkmqGSLEDQIIAANPLLEAYGNAKTVRNDNSSRF 248
Cdd:pfam00063   81 QDKENQSILISGESGAGKTENTKKIMQYLASVSGSGSAGNV--------GRLEEQILQSNPILEAFGNAKTVRNNNSSRF 152
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   249 GKFIRIHFGTSGKLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPELIEmTLITTNPYDFPMCSQ-GQITVASI 327
Cdd:pfam00063  153 GKYIEIQFDAKGDIVGGKIETYLLEKSRVVYQAEGERNYHIFYQLLAGASAQLKK-ELRLTNPKDYHYLSQsGCYTIDGI 231
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   328 DDKEELVATDTAIDILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQREEQAEPDGTEEADKIGYLLGLNSADMLKALCYPR 407
Cdd:pfam00063  232 DDSEEFKITDKAMDILGFSDEEQMGIFRIVAAILHLGNIEFKKERNDEQAVPDDTENLQKAASLLGIDSTELEKALCKRR 311
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   408 VKVGNEFVTKGQTVPQVYNSVSALSKSIYERMFLWMVVRINQMLDTKQ-QRNFFIGVLDIAGFEIFDFNSMEQLCINFTN 486
Cdd:pfam00063  312 IKTGRETVSKPQNVEQANYARDALAKAIYSRLFDWLVDRINKSLDVKTiEKASFIGVLDIYGFEIFEKNSFEQLCINYVN 391
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   487 EKLQQFFNHHMFVLEQEEYKKEGIVWEFIDFGmDLAACIELIE-KPLGIFSILEEECMFPKATDTSFKNKLYDQHlGKCN 565
Cdd:pfam00063  392 EKLQQFFNHHMFKLEQEEYVREGIEWTFIDFG-DNQPCIDLIEkKPLGILSLLDEECLFPKATDQTFLDKLYSTF-SKHP 469
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   566 AFQKPKPakgKAEAHFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYPPVVEETGGGKKGGKKKG-- 643
Cdd:pfam00063  470 HFQKPRL---QGETHFIIKHYAGDVEYNVEGFLEKNKDPLNDDLVSLLKSSSDPLLAELFPDYETAESAAANESGKSTpk 546
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   644 ----GSMQTVSSQFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYAD 719
Cdd:pfam00063  547 rtkkKRFITVGSQFKESLGELMKTLNSTNPHYIRCIKPNEKKRAGVFDNSLVLHQLRCNGVLEGIRIRRAGFPNRITFQE 626
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*....
gi 288856329   720 FKQRYKVLNASVIPEGqFIDNKKASEKLLGSIDVNHDEYRFGHTKVFFK 768
Cdd:pfam00063  627 FVQRYRILAPKTWPKW-KGDAKKGCEAILQSLNLDKEEYQFGKTKIFFR 674
MYSc smart00242
Myosin. Large ATPases; ATPase; molecular motor. Muscle contraction consists of a cyclical ...
82-780 0e+00

Myosin. Large ATPases; ATPase; molecular motor. Muscle contraction consists of a cyclical interaction between myosin and actin. The core of the myosin structure is similar in fold to that of kinesin.


Pssm-ID: 214580 [Multi-domain]  Cd Length: 677  Bit Score: 965.86  E-value: 0e+00
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329     82 NPPKFDKIEDMAMMTHLNEPSVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRMEAPPHIFSVSD 161
Cdd:smart00242    1 NPPKFEGVEDLVLLTYLNEPAVLHNLKKRYLKDLIYTYIGLVLVAVNPYKQLPIYTDEVIKKYRGKSRGELPPHVFAIAD 80
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329    162 NAYQFMLTDRENQSVLITGESGAGKTVNTKRVIQYFATVAvqgpekkkeqASGKMQGSLEDQIIAANPLLEAYGNAKTVR 241
Cdd:smart00242   81 NAYRNMLNDKENQSIIISGESGAGKTENTKKIMQYLASVS----------GSNTEVGSVEDQILESNPILEAFGNAKTLR 150
                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329    242 NDNSSRFGKFIRIHFGTSGKLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPELIEmTLITTNPYDFPMCSQGQ 321
Cdd:smart00242  151 NNNSSRFGKFIEIHFDAKGKIIGAKIETYLLEKSRVVSQAKGERNYHIFYQLLAGASEELKK-ELGLKSPEDYRYLNQGG 229
                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329    322 -ITVASIDDKEELVATDTAIDILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQREEQA-EPDGTEEADKIGYLLGLNSADM 399
Cdd:smart00242  230 cLTVDGIDDAEEFKETLNAMRVLGFSEEEQESIFKILAAILHLGNIEFEEGRNDNAAsTVKDKEELSNAAELLGVDPEEL 309
                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329    400 LKALCYPRVKVGNEFVTKGQTVPQVYNSVSALSKSIYERMFLWMVVRINQMLDTKQQRNFFIGVLDIAGFEIFDFNSMEQ 479
Cdd:smart00242  310 EKALTKRKIKTGGEVITKPLNVEQALDARDALAKALYSRLFDWLVKRINQSLSFKDGSTYFIGVLDIYGFEIFEVNSFEQ 389
                           410       420       430       440       450       460       470       480
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329    480 LCINFTNEKLQQFFNHHMFVLEQEEYKKEGIVWEFIDFGmDLAACIELIE-KPLGIFSILEEECMFPKATDTSFKNKLYd 558
Cdd:smart00242  390 LCINYANEKLQQFFNQHVFKLEQEEYEREGIDWTFIDFF-DNQDCIDLIEkKPPGILSLLDEECRFPKGTDQTFLEKLN- 467
                           490       500       510       520       530       540       550       560
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329    559 QHLGKCNAFQKPKPakgKAEAHFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYPPVVEETgggkkg 638
Cdd:smart00242  468 QHHKKHPHFSKPKK---KGRTEFIIKHYAGDVTYDVTGFLEKNKDTLSDDLIELLQSSKNPLIASLFPSGVSNA------ 538
                           570       580       590       600       610       620       630       640
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329    639 gkKKGGSMQTVSSQFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYA 718
Cdd:smart00242  539 --GSKKRFQTVGSQFKEQLNELMDTLNSTNPHFIRCIKPNEEKKPGDFDSSLVLHQLRYLGVLENIRIRRAGFPYRLPFD 616
                           650       660       670       680       690       700
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 288856329    719 DFKQRYKVLNASVIPEGQFiDNKKASEKLLGSIDVNHDEYRFGHTKVFFKAGLLGTLEEMRD 780
Cdd:smart00242  617 EFLQRYRVLLPDTWPPWGG-DAKKACEALLQSLGLDEDEYQLGKTKVFLRPGQLAELEELRE 677
MYSc_Myh16 cd14934
class II myosin heavy chain 16, motor domain; Myosin motor domain of myosin heavy chain 16 ...
102-768 0e+00

class II myosin heavy chain 16, motor domain; Myosin motor domain of myosin heavy chain 16 pseudogene (also called MHC20, MYH16, and myh5), encoding a sarcomeric myosin heavy chain expressed in nonhuman primate masticatory muscles, is inactivated in humans. This cd contains Myh16 in mammals. MYH16 has intermediate fibres between that of slow type 1 and fast 2B fibres, but exert more force than any other fibre type examined. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. Some of the data used for this classification were produced by the CyMoBase team at the Max-Planck-Institute for Biophysical Chemistry. The sequence names are composed of the species abbreviation followed by the protein abbreviation and optional protein classifier and variant designations.


Pssm-ID: 276896 [Multi-domain]  Cd Length: 659  Bit Score: 965.65  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  102 SVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLITGE 181
Cdd:cd14934     2 SVLDNLRQRYTNMRIYTYSGLFCVTVNPYKWLPIYGARVANMYKGKKRTEMPPHLFSISDNAYHDMLMDRENQSMLITGE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  182 SGAGKTVNTKRVIQYFATVAVQGpekkKEQASGKmqGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTSGK 261
Cdd:cd14934    82 SGAGKTENTKKVIQYFANIGGTG----KQSSDGK--GSLEDQIIQANPVLEAFGNAKTTRNNNSSRFGKFIRIHFGTTGK 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  262 LASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPELIEMTLITTNPYDFPMCSQGQITVASIDDKEELVATDTAID 341
Cdd:cd14934   156 LAGADIESYLLEKSRVISQQAAERGYHIFYQILSNKKPELIESLLLVPNPKEYHWVSQGVTVVDNMDDGEELQITDVAFD 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  342 ILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQREEQAEPDGTEEADKIGYLLGLNSADMLKALCYPRVKVGNEFVTKGQTV 421
Cdd:cd14934   236 VLGFSAEEKIGVYKLTGGIMHFGNMKFKQKPREEQAEVDTTEVADKVAHLMGLNSGELQKGITRPRVKVGNEFVQKGQNM 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  422 PQVYNSVSALSKSIYERMFLWMVVRINQMLDTKQQRNFFIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFNHHMFVLE 501
Cdd:cd14934   316 EQCNNSIGALGKAVYDKMFKWLVVRINKTLDTKMQRQFFIGVLDIAGFEIFEFNSFEQLCINFTNEKLQQFFNHHMFVLE 395
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  502 QEEYKKEGIVWEFIDFGMDLAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQHLGKCNAFQKPKPAKGK-AEAH 580
Cdd:cd14934   396 QEEYKREGIEWVFIDFGLDLQACIDLLEKPMGIFSILEEQCVFPKATDATFKAALYDNHLGKSSNFLKPKGGKGKgPEAH 475
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  581 FSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYPpvvEETGGGKKGGKKKGGSMQTVSSQFRENLGKL 660
Cdd:cd14934   476 FELVHYAGTVGYNITGWLEKNKDPLNETVVGLFQKSSLGLLALLFK---EEEAPAGSKKQKRGSSFMTVSNFYREQLNKL 552
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  661 MTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASVIPEGqFIDN 740
Cdd:cd14934   553 MTTLHSTAPHFVRCIVPNEFKQSGVVDAHLIMHQLACNGVLEGIRICRKGFPNRLQYPEFKQRYQVLNPNVIPQG-FVDN 631
                         650       660
                  ....*....|....*....|....*...
gi 288856329  741 KKASEKLLGSIDVNHDEYRFGHTKVFFK 768
Cdd:cd14934   632 KKASELLLGSIDLDVNEYKIGHTKVFFR 659
MYSc_Myh1_insects_crustaceans cd14909
class II myosin heavy chain 1, motor domain; Myosin motor domain of type IIx skeletal muscle ...
101-768 0e+00

class II myosin heavy chain 1, motor domain; Myosin motor domain of type IIx skeletal muscle myosin heavy chain 1 (also called MYHSA1, MYHa, MyHC-2X/D, MGC133384) in insects and crustaceans. Myh1 is a type I skeletal muscle myosin that in Humans is encoded by the MYH1 gene. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276874  Cd Length: 666  Bit Score: 939.65  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  101 PSVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLITG 180
Cdd:cd14909     1 ASVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  181 ESGAGKTVNTKRVIQYFATVavqGPEKKKEQASGKmQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTSG 260
Cdd:cd14909    81 ESGAGKTENTKKVIAYFATV---GASKKTDEAAKS-KGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTG 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  261 KLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPELIEMTLITTNPYDFPMCSQGQITVASIDDKEELVATDTAI 340
Cdd:cd14909   157 KLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVKEMCLLSDNIYDYYIVSQGKVTVPNVDDGEEFSLTDQAF 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  341 DILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQREEQAEPDGTEEADKIGYLLGLNSADMLKALCYPRVKVGNEFVTKGQT 420
Cdd:cd14909   237 DILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRN 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  421 VPQVYNSVSALSKSIYERMFLWMVVRINQMLDTKQQRNFFIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFNHHMFVL 500
Cdd:cd14909   317 VQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVL 396
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  501 EQEEYKKEGIVWEFIDFGMDLAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQHLGKCNAFQKPKPAK-GKAEA 579
Cdd:cd14909   397 EQEEYKREGIDWAFIDFGMDLLACIDLIEKPMGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKpGQQAA 476
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  580 HFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLY---PPVVEETGGGKKGGKKKGGSMQTVSSQFREN 656
Cdd:cd14909   477 HFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIFadhAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQ 556
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  657 LGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASVIPEGQ 736
Cdd:cd14909   557 LNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKILNPAGIQGEE 636
                         650       660       670
                  ....*....|....*....|....*....|..
gi 288856329  737 fiDNKKASEKLLGSIDVNHDEYRFGHTKVFFK 768
Cdd:cd14909   637 --DPKKAAEIILESIALDPDQYRLGHTKVFFR 666
MYSc cd00124
Myosin motor domain superfamily; Myosin motor domain. The catalytic (head) domain has ATPase ...
101-768 0e+00

Myosin motor domain superfamily; Myosin motor domain. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276950 [Multi-domain]  Cd Length: 633  Bit Score: 811.05  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  101 PSVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKR-MEAPPHIFSVSDNAYQFMLTDRENQSVLIT 179
Cdd:cd00124     1 AAILHNLRERYARDLIYTYVGDILVAVNPFKWLPLYSEEVMEKYRGKGRsADLPPHVFAVADAAYRAMLRDGQNQSILIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  180 GESGAGKTVNTKRVIQYFATVAVQGPEKKKEQASgkmqgSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTS 259
Cdd:cd00124    81 GESGAGKTETTKLVLKYLAALSGSGSSKSSSSAS-----SIEQQILQSNPILEAFGNAKTVRNDNSSRFGKFIELQFDPT 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  260 GKLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPELIEMTLITTNPYDFPM----CSQGQITVASIDDKEELVA 335
Cdd:cd00124   156 GRLVGASIETYLLEKSRVVSQAPGERNFHIFYQLLAGLSDGAREELKLELLLSYYYLndylNSSGCDRIDGVDDAEEFQE 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  336 TDTAIDILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQREE--QAEPDGTEEADKIGYLLGLNSADMLKALCYPRVKVGNE 413
Cdd:cd00124   236 LLDALDVLGFSDEEQDSIFRILAAILHLGNIEFEEDEEDEdsSAEVADDESLKAAAKLLGVDAEDLEEALTTRTIKVGGE 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  414 FVTKGQTVPQVYNSVSALSKSIYERMFLWMVVRINQMLDTKQQRNF--FIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQ 491
Cdd:cd00124   316 TITKPLTVEQAEDARDALAKALYSRLFDWLVNRINAALSPTDAAEStsFIGILDIFGFENFEVNSFEQLCINYANEKLQQ 395
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  492 FFNHHMFVLEQEEYKKEGIVWEFIDFgMDLAACIELIE-KPLGIFSILEEECMFPKATDTSFKNKLYDQHLGKCNAFQKP 570
Cdd:cd00124   396 FFNQHVFKLEQEEYEEEGIDWSFIDF-PDNQDCLDLIEgKPLGILSLLDEECLFPKGTDATFLEKLYSAHGSHPRFFSKK 474
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  571 KpakgKAEAHFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKssvkllatlyppvveetgggkkggkkkggsmqtvS 650
Cdd:cd00124   475 R----KAKLEFGIKHYAGDVTYDADGFLEKNKDTLPPDLVDLLRS----------------------------------G 516
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  651 SQFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNAS 730
Cdd:cd00124   517 SQFRSQLDALMDTLNSTQPHFVRCIKPNDEKKPGLFDPELVLEQLRCAGVLEAVRIRRAGYPVRLPFDEFLKRYRILAPG 596
                         650       660       670
                  ....*....|....*....|....*....|....*...
gi 288856329  731 vIPEGQFIDNKKASEKLLGSIDVNHDEYRFGHTKVFFK 768
Cdd:cd00124   597 -ATEKASDSKKAAVLALLLLLKLDSSGYQLGKTKVFLR 633
COG5022 COG5022
Myosin heavy chain [General function prediction only];
32-1114 0e+00

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 809.69  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   32 FDAKTACYVVDDKELYVKGTIKSKD--GGKVTV------ITLDTKEEKVVKEDDvhpMNPPKFDKIEDMAMMTHLNEPSV 103
Cdd:COG5022     6 AEVGSGCWIPDEEKGWIWAEIIKEAfnKGKVTEegkkedGESVSVKKKVLGNDR---IKLPKFDGVDDLTELSYLNEPAV 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  104 LYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLITGESG 183
Cdd:COG5022    83 LHNLEKRYNNGQIYTYSGLVLIAVNPYRDLGIYTDDIIQSYSGKNRLELEPHVFAIAEEAYRNLLSEKENQTIIISGESG 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  184 AGKTVNTKRVIQYFATVavqgpekkkEQASGKMQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTSGKLA 263
Cdd:COG5022   163 AGKTENAKRIMQYLASV---------TSSSTVEISSIEKQILATNPILEAFGNAKTVRNDNSSRFGKYIKIEFDENGEIC 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  264 SADIETYLLEKSRVTFQLPDERGYHIFYQMMTNhKPELIEMTLITTNPYDFPMCSQG-QITVASIDDKEELVATDTAIDI 342
Cdd:COG5022   234 GAKIETYLLEKSRVVHQNKNERNYHIFYQLLAG-DPEELKKLLLLQNPKDYIYLSQGgCDKIDGIDDAKEFKITLDALKT 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  343 LGFNNEEKMGIYKFTGAVLHHGNMKFKqKQREEQAEPDGTEEADKIGYLLGLNSADMLKALCYPRVKVGNEFVTKGQTVP 422
Cdd:COG5022   313 IGIDEEEQDQIFKILAAILHIGNIEFK-EDRNGAAIFSDNSVLDKACYLLGIDPSLFVKWLVKRQIKTGGEWIVVPLNLE 391
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  423 QVYNSVSALSKSIYERMFLWMVVRINQMLDTKQQRNFFIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFNHHMFVLEQ 502
Cdd:COG5022   392 QALAIRDSLAKALYSNLFDWIVDRINKSLDHSAAASNFIGVLDIYGFEIFEKNSFEQLCINYTNEKLQQFFNQHMFKLEQ 471
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  503 EEYKKEGIVWEFIDFgMDLAACIELIEK--PLGIFSILEEECMFPKATDTSFKNKLYDQ-HLGKCNAFQKPKPAKGKaea 579
Cdd:COG5022   472 EEYVKEGIEWSFIDY-FDNQPCIDLIEKknPLGILSLLDEECVMPHATDESFTSKLAQRlNKNSNPKFKKSRFRDNK--- 547
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  580 hFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYPPVVEetgggkkggKKKGGSMQTVSSQFRENLGK 659
Cdd:COG5022   548 -FVVKHYAGDVEYDVEGFLDKNKDPLNDDLLELLKASTNEFVSTLFDDEEN---------IESKGRFPTLGSRFKESLNS 617
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  660 LMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASVIPEGQFI- 738
Cdd:COG5022   618 LMSTLNSTQPHYIRCIKPNEEKSPWTFDNQMVLSQLRCCGVLETIRISRAGFPSRWTFDEFVQRYRILSPSKSWTGEYTw 697
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  739 --DNKKASEKLLGSIDVNHDEYRFGHTKVFFKAGLLGTLEEMRDEKLASLVTMTQALCRAYLMRREFVKMMERRDAIYTI 816
Cdd:COG5022   698 keDTKNAVKSILEELVIDSSKYQIGNTKVFFKAGVLAALEDMRDAKLDNIATRIQRAIRGRYLRRRYLQALKRIKKIQVI 777
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  817 QYNVRSFMNVKHWPWMKVYYKIKPLLKSAETEKELatmkEDFVKCKEDLAKAEAKKKELEEKMVALLQEKNDLQLAVASE 896
Cdd:COG5022   778 QHGFRLRRLVDYELKWRLFIKLQPLLSLLGSRKEY----RSYLACIIKLQKTIKREKKLRETEEVEFSLKAEVLIQKFGR 853
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  897 SENLS---DAEERCEGLIKSKIQLEAKLKETTERLEDEEEINaELTAKKRKLEDECSELKKDID-----DLELTLAKVEK 968
Cdd:COG5022   854 SLKAKkrfSLLKKETIYLQSAQRVELAERQLQELKIDVKSIS-SLKLVNLELESEIIELKKSLSsdlieNLEFKTELIAR 932
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  969 EKHATEN-KVKNLTEEMAAQDESIGKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKSKTKLEQQVDDLEGSLEQekklR 1047
Cdd:COG5022   933 LKKLLNNiDLEEGPSIEYVKLPELNKLHEVESKLKETSEEYEDLLKKSTILVREGNKANSELKNFKKELAELSKQ----Y 1008
                        1050      1060      1070      1080      1090      1100      1110
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 288856329 1048 MDLERAKRKLEgdlklaqesIMDLENDKQQSEEKLKKKDFETSQLLSKIEDEQSL----GAQLQKKIKELQ 1114
Cdd:COG5022  1009 GALQESTKQLK---------ELPVEVAELQSASKIISSESTELSILKPLQKLKGLllleNNQLQARYKALK 1070
MYSc_Myh2_insects_mollusks cd14911
class II myosin heavy chain 2, motor domain; Myosin motor domain of type IIa skeletal muscle ...
102-768 0e+00

class II myosin heavy chain 2, motor domain; Myosin motor domain of type IIa skeletal muscle myosin heavy chain 2 (also called MYH2A, MYHSA2, MyHC-IIa, MYHas8, MyHC-2A) in insects and mollusks. This gene encodes a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction. Mutations in this gene results in inclusion body myopathy-3 and familial congenital myopathy. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276876 [Multi-domain]  Cd Length: 674  Bit Score: 767.99  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  102 SVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLITGE 181
Cdd:cd14911     2 SVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  182 SGAGKTVNTKRVIQYFATVAVQGPEK-----KKEQASGKMQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHF 256
Cdd:cd14911    82 SGAGKTENTKKVIQFLAYVAASKPKGsgavpHPAVNPAVLIGELEQQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINF 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  257 GTSGKLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPELIEmTLITTNPYDFPMCSQGQITVASIDDKEELVAT 336
Cdd:cd14911   162 DASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQRE-KFILDDVKSYAFLSNGSLPVPGVDDYAEFQAT 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  337 DTAIDILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQREEQAE-PDGTEeADKIGYLLGLNSADMLKALCYPRVKVGNEFV 415
Cdd:cd14911   241 VKSMNIMGMTSEDFNSIFRIVSAVLLFGSMKFRQERNNDQATlPDNTV-AQKIAHLLGLSVTDMTRAFLTPRIKVGRDFV 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  416 TKGQTVPQVYNSVSALSKSIYERMFLWMVVRINQMLD-TKQQRNFFIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFN 494
Cdd:cd14911   320 TKAQTKEQVEFAVEAIAKACYERMFKWLVNRINRSLDrTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQLFN 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  495 HHMFVLEQEEYKKEGIVWEFIDFGMDLAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQHlgkcNAFQKPKPAK 574
Cdd:cd14911   400 HTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTFVDKLVSAH----SMHPKFMKTD 475
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  575 GKAEAHFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYPP-----VVEETGGGKKGGKKKGGSM-QT 648
Cdd:cd14911   476 FRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWKDaeivgMAQQALTDTQFGARTRKGMfRT 555
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  649 VSSQFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLN 728
Cdd:cd14911   556 VSHLYKEQLAKLMDTLRNTNPNFVRCIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLT 635
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|
gi 288856329  729 ASVIPEGqFIDNKKASEKLLGSIDVNHDEYRFGHTKVFFK 768
Cdd:cd14911   636 PNVIPKG-FMDGKKACEKMIQALELDSNLYRVGQSKIFFR 674
MYSc_Myh10 cd14920
class II myosin heavy chain 10, motor domain; Myosin motor domain of non-muscle myosin heavy ...
102-768 0e+00

class II myosin heavy chain 10, motor domain; Myosin motor domain of non-muscle myosin heavy chain 10 (also called NMMHCB). Mutations in this gene have been associated with May-Hegglin anomaly and developmental defects in brain and heart. Multiple transcript variants encoding different isoforms have been found for this gene. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276952 [Multi-domain]  Cd Length: 673  Bit Score: 742.21  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  102 SVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLITGE 181
Cdd:cd14920     2 SVLHNLKDRYYSGLIYTYSGLFCVVINPYKNLPIYSENIIEMYRGKKRHEMPPHIYAISESAYRCMLQDREDQSILCTGE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  182 SGAGKTVNTKRVIQYFATVAvqgpEKKKEQASGKMQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTSGK 261
Cdd:cd14920    82 SGAGKTENTKKVIQYLAHVA----SSHKGRKDHNIPGELERQLLQANPILESFGNAKTVKNDNSSRFGKFIRINFDVTGY 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  262 LASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPEL-IEMTLITTNPYDFpmCSQGQITVASIDDKEELVATDTAI 340
Cdd:cd14920   158 IVGANIETYLLEKSRAVRQAKDERTFHIFYQLLSGAGEHLkSDLLLEGFNNYRF--LSNGYIPIPGQQDKDNFQETMEAM 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  341 DILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQREEQAE-PDGTeEADKIGYLLGLNSADMLKALCYPRVKVGNEFVTKGQ 419
Cdd:cd14920   236 HIMGFSHEEILSMLKVVSSVLQFGNISFKKERNTDQASmPENT-VAQKLCHLLGMNVMEFTRAILTPRIKVGRDYVQKAQ 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  420 TVPQVYNSVSALSKSIYERMFLWMVVRINQMLD-TKQQRNFFIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFNHHMF 498
Cdd:cd14920   315 TKEQADFAVEALAKATYERLFRWLVHRINKALDrTKRQGASFIGILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMF 394
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  499 VLEQEEYKKEGIVWEFIDFGMDLAACIELIEKPL---GIFSILEEECMFPKATDTSFKNKLyDQHLGKCNAFQKPKPAKG 575
Cdd:cd14920   395 ILEQEEYQREGIEWNFIDFGLDLQPCIDLIERPAnppGVLALLDEECWFPKATDKTFVEKL-VQEQGSHSKFQKPRQLKD 473
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  576 KAEahFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYPPVVE---------ETGGGKKGGKKKGGSM 646
Cdd:cd14920   474 KAD--FCIIHYAGKVDYKADEWLMKNMDPLNDNVATLLHQSSDRFVAELWKDVDRivgldqvtgMTETAFGSAYKTKKGM 551
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  647 -QTVSSQFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYK 725
Cdd:cd14920   552 fRTVGQLYKESLTKLMATLRNTNPNFVRCIIPNHEKRAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYE 631
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|...
gi 288856329  726 VLNASVIPEGqFIDNKKASEKLLGSIDVNHDEYRFGHTKVFFK 768
Cdd:cd14920   632 ILTPNAIPKG-FMDGKQACERMIRALELDPNLYRIGQSKIFFR 673
MYSc_Myh18 cd14932
class II myosin heavy chain 18, motor domain; Myosin motor domain of muscle myosin heavy chain ...
102-768 0e+00

class II myosin heavy chain 18, motor domain; Myosin motor domain of muscle myosin heavy chain 18. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276895 [Multi-domain]  Cd Length: 676  Bit Score: 702.55  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  102 SVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLITGE 181
Cdd:cd14932     2 SVLHNLKERYYSGLIYTYSGLFCVVINPYKYLPIYSEEIVNMYKGKKRHEMPPHIYAITDTAYRSMMQDREDQSILCTGE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  182 SGAGKTVNTKRVIQYFATVAVQGPEKKKEQASGKMQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTSGK 261
Cdd:cd14932    82 SGAGKTENTKKVIQYLAYVASSFKTKKDQSSIALSHGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNGY 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  262 LASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPEL-IEMTLITTNPYDFpmCSQGQITVASIDDKEELVATDTAI 340
Cdd:cd14932   162 IVGANIETYLLEKSRAIRQAKDERAFHIFYYLLTGAGDKLrSELCLEDYSKYRF--LSNGNVTIPGQQDKELFAETMEAF 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  341 DILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQREEQAE-PDGTeEADKIGYLLGLNSADMLKALCYPRVKVGNEFVTKGQ 419
Cdd:cd14932   240 RIMSIPEEEQTGLLKVVSAVLQLGNMSFKKERNSDQASmPDDT-AAQKVCHLLGMNVTDFTRAILSPRIKVGRDYVQKAQ 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  420 TVPQVYNSVSALSKSIYERMFLWMVVRINQMLD-TKQQRNFFIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFNHHMF 498
Cdd:cd14932   319 TQEQAEFAVEALAKASYERMFRWLVMRINKALDkTKRQGASFIGILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMF 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  499 VLEQEEYKKEGIVWEFIDFGMDLAACIELIEKPL---GIFSILEEECMFPKATDTSFKNKLYdQHLGKCNAFQKPKpaKG 575
Cdd:cd14932   399 ILEQEEYQREGIEWSFIDFGLDLQPCIELIEKPNgppGILALLDEECWFPKATDKSFVEKVV-QEQGNNPKFQKPK--KL 475
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  576 KAEAHFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYPPV--------VEETGGGKKGGKKKGGSM- 646
Cdd:cd14932   476 KDDADFCIIHYAGKVDYKANEWLMKNMDPLNENVATLLNQSTDKFVSELWKDVdrivgldkVAGMGESLHGAFKTRKGMf 555
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  647 QTVSSQFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKV 726
Cdd:cd14932   556 RTVGQLYKEQLMNLMTTLRNTNPNFVRCIIPNHEKKAGKLAHHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEI 635
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|..
gi 288856329  727 LNASVIPEGqFIDNKKASEKLLGSIDVNHDEYRFGHTKVFFK 768
Cdd:cd14932   636 LTPNAIPKG-FMDGKQACVLMVKALELDPNLYRIGQSKVFFR 676
MYSc_Myo5 cd01380
class V myosin, motor domain; Myo5, also called heavy chain 12, myoxin, are dimeric myosins ...
101-768 0e+00

class V myosin, motor domain; Myo5, also called heavy chain 12, myoxin, are dimeric myosins that transport a variety of intracellular cargo processively along actin filaments, such as melanosomes, synaptic vesicles, vacuoles, and mRNA. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. It also contains a IQ domain and a globular DIL domain. Myosin V is a class of actin-based motor proteins involved in cytoplasmic vesicle transport and anchorage, spindle-pole alignment and mRNA translocation. The protein encoded by this gene is abundant in melanocytes and nerve cells. Mutations in this gene cause Griscelli syndrome type-1 (GS1), Griscelli syndrome type-3 (GS3) and neuroectodermal melanolysosomal disease, or Elejalde disease. Multiple alternatively spliced transcript variants encoding different isoforms have been reported, but the full-length nature of some variants has not been determined. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. Note that the Dictyostelium myoVs are not contained in this child group. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276831 [Multi-domain]  Cd Length: 629  Bit Score: 690.82  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  101 PSVLYNLKERYA-AWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLIT 179
Cdd:cd01380     1 PAVLHNLKVRFCqRNAIYTYCGIVLVAINPYEDLPIYGEDIIQAYSGQNMGELDPHIFAIAEEAYRQMARDEKNQSIIVS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  180 GESGAGKTVNTKRVIQYFATVavqgpekkkeQASGKMQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTS 259
Cdd:cd01380    81 GESGAGKTVSAKYAMRYFATV----------GGSSSGETQVEEKVLASNPIMEAFGNAKTTRNDNSSRFGKYIEILFDKN 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  260 GKLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTN-HKPELIEMTLiTTNPYDFPMCSQGQITVASIDDKEELVATDT 338
Cdd:cd01380   151 YRIIGANMRTYLLEKSRVVFQAEEERNYHIFYQLCAAaSLPELKELHL-GSAEDFFYTNQGGSPVIDGVDDAAEFEETRK 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  339 AIDILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQREEQAEPDGTEEADKIGYLLGLNSADMLKALCYPRVKVGNEFVTKG 418
Cdd:cd01380   230 ALTLLGISEEEQMEIFRILAAILHLGNVEIKATRNDSASISPDDEHLQIACELLGIDESQLAKWLCKRKIVTRSEVIVKP 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  419 QTVPQVYNSVSALSKSIYERMFLWMVVRINQMLDTKQ--QRNFFIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFNHH 496
Cdd:cd01380   310 LTLQQAIVARDALAKHIYAQLFDWIVDRINKALASPVkeKQHSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQH 389
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  497 MFVLEQEEYKKEGIVWEFIDFgMDLAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQHLGKCNA-FQKPKPAKG 575
Cdd:cd01380   390 VFKLEQEEYVKEEIEWSFIDF-YDNQPCIDLIEGKLGILDLLDEECRLPKGSDENWAQKLYNQHLKKPNKhFKKPRFSNT 468
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  576 KaeahFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLlatlyppvveetgggkkggkkkggsmQTVSSQFRE 655
Cdd:cd01380   469 A----FIVKHFADDVEYQVEGFLEKNRDTVSEEHLNVLKASKNRK--------------------------KTVGSQFRD 518
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  656 NLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASviPEG 735
Cdd:cd01380   519 SLILLMETLNSTTPHYVRCIKPNDEKLPFTFDPKRVVQQLRACGVLETIRISAAGFPSRWTYEEFFSRYRVLLPS--KEW 596
                         650       660       670
                  ....*....|....*....|....*....|...
gi 288856329  736 QFIDNKKASEKLLGSIDVNHDEYRFGHTKVFFK 768
Cdd:cd01380   597 LRDDKKKTCENILENLILDPDKYQFGKTKIFFR 629
MYSc_Myh11 cd14921
class II myosin heavy chain 11, motor domain; Myosin motor domain of smooth muscle myosin ...
102-768 0e+00

class II myosin heavy chain 11, motor domain; Myosin motor domain of smooth muscle myosin heavy chain 11 (also called SMMHC, SMHC). The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. Inversion of the MYH11 locus is one of the most frequent chromosomal aberrations found in acute myeloid leukemia. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Mutations in MYH11 have been described in individuals with thoracic aortic aneurysms leading to acute aortic dissections with patent ductus arteriosus. MYH11 mutations are also thought to contribute to human colorectal cancer and are also associated with Peutz-Jeghers syndrome. The mutations found in human intestinal neoplasia result in unregulated proteins with constitutive motor activity, similar to the mutant myh11 zebrafish. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276885 [Multi-domain]  Cd Length: 673  Bit Score: 673.65  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  102 SVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLITGE 181
Cdd:cd14921     2 SVLHNLRERYFSGLIYTYSGLFCVVVNPYKHLPIYSEKIVDMYKGKKRHEMPPHIYAIADTAYRSMLQDREDQSILCTGE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  182 SGAGKTVNTKRVIQYFATVAVQGPEKKKEQASGKmqgsLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTSGK 261
Cdd:cd14921    82 SGAGKTENTKKVIQYLAVVASSHKGKKDTSITGE----LEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTGY 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  262 LASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPELIEMTLITT-NPYDFpmCSQGQITVASIDDKEELVATDTAI 340
Cdd:cd14921   158 IVGANIETYLLEKSRAIRQARDERTFHIFYYLIAGAKEKMRSDLLLEGfNNYTF--LSNGFVPIPAAQDDEMFQETLEAM 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  341 DILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQREEQAE-PDGTeEADKIGYLLGLNSADMLKALCYPRVKVGNEFVTKGQ 419
Cdd:cd14921   236 SIMGFSEEEQLSILKVVSSVLQLGNIVFKKERNTDQASmPDNT-AAQKVCHLMGINVTDFTRSILTPRIKVGRDVVQKAQ 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  420 TVPQVYNSVSALSKSIYERMFLWMVVRINQMLD-TKQQRNFFIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFNHHMF 498
Cdd:cd14921   315 TKEQADFAIEALAKATYERLFRWILTRVNKALDkTHRQGASFLGILDIAGFEIFEVNSFEQLCINYTNEKLQQLFNHTMF 394
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  499 VLEQEEYKKEGIVWEFIDFGMDLAACIELIEKPL---GIFSILEEECMFPKATDTSFKNKLYdQHLGKCNAFQKPKPAKG 575
Cdd:cd14921   395 ILEQEEYQREGIEWNFIDFGLDLQPCIELIERPNnppGVLALLDEECWFPKATDKSFVEKLC-TEQGNHPKFQKPKQLKD 473
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  576 KAEahFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYPPV---------VEETGGGKKGGKKKGGSM 646
Cdd:cd14921   474 KTE--FSIIHYAGKVDYNASAWLTKNMDPLNDNVTSLLNASSDKFVADLWKDVdrivgldqmAKMTESSLPSASKTKKGM 551
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  647 -QTVSSQFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYK 725
Cdd:cd14921   552 fRTVGQLYKEQLGKLMTTLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYE 631
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|...
gi 288856329  726 VLNASVIPEGqFIDNKKASEKLLGSIDVNHDEYRFGHTKVFFK 768
Cdd:cd14921   632 ILAANAIPKG-FMDGKQACILMIKALELDPNLYRIGQSKIFFR 673
MYSc_Myh19 cd15896
class II myosin heavy chain19, motor domain; Myosin motor domain of muscle myosin heavy chain ...
102-768 0e+00

class II myosin heavy chain19, motor domain; Myosin motor domain of muscle myosin heavy chain 19. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276899 [Multi-domain]  Cd Length: 675  Bit Score: 654.83  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  102 SVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLITGE 181
Cdd:cd15896     2 SVLHNLKERYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVEMYKGKKRHEMPPHIYAITDTAYRSMMQDREDQSILCTGE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  182 SGAGKTVNTKRVIQYFATVAVQGPEKKKEQASGKMQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTSGK 261
Cdd:cd15896    82 SGAGKTENTKKVIQYLAHVASSHKTKKDQNSLALSHGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNGY 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  262 LASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPEL-IEMTLITTNPYDFpmCSQGQITVASIDDKEELVATDTAI 340
Cdd:cd15896   162 IVGANIETYLLEKSRAIRQAKEERTFHIFYYLLTGAGDKLrSELLLENYNNYRF--LSNGNVTIPGQQDKDLFTETMEAF 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  341 DILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQREEQAEPDGTEEADKIGYLLGLNSADMLKALCYPRVKVGNEFVTKGQT 420
Cdd:cd15896   240 RIMGIPEDEQIGMLKVVASVLQLGNMSFKKERHTDQASMPDNTAAQKVCHLMGMNVTDFTRAILSPRIKVGRDYVQKAQT 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  421 VPQVYNSVSALSKSIYERMFLWMVVRINQMLD-TKQQRNFFIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFNHHMFV 499
Cdd:cd15896   320 QEQAEFAVEALAKATYERMFRWLVMRINKALDkTKRQGASFIGILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFI 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  500 LEQEEYKKEGIVWEFIDFGMDLAACIELIEKPL---GIFSILEEECMFPKATDTSFKNKLYdQHLGKCNAFQKPKpaKGK 576
Cdd:cd15896   400 LEQEEYQREGIEWSFIDFGLDLQPCIDLIEKPAsppGILALLDEECWFPKATDKSFVEKVL-QEQGTHPKFFKPK--KLK 476
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  577 AEAHFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYPPV--------VEETGGGKKGGKKKGGSMQT 648
Cdd:cd15896   477 DEADFCIIHYAGKVDYKADEWLMKNMDPLNDNVATLLNQSTDKFVSELWKDVdrivgldkVSGMSEMPGAFKTRKGMFRT 556
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  649 VSSQFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLN 728
Cdd:cd15896   557 VGQLYKEQLSKLMATLRNTNPNFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILT 636
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|
gi 288856329  729 ASVIPEGqFIDNKKASEKLLGSIDVNHDEYRFGHTKVFFK 768
Cdd:cd15896   637 PNAIPKG-FMDGKQACVLMIKSLELDPNLYRIGQSKVFFR 675
MYSc_Myh9 cd14919
class II myosin heavy chain 9, motor domain; Myosin motor domain of non-muscle myosin heavy ...
102-768 0e+00

class II myosin heavy chain 9, motor domain; Myosin motor domain of non-muscle myosin heavy chain 9 (also called NMMHCA, NMHC-II-A, MHA, FTNS, EPSTS, and DFNA17). Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. The encoded protein is a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain which is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in this gene have been associated with non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276883 [Multi-domain]  Cd Length: 670  Bit Score: 652.16  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  102 SVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLITGE 181
Cdd:cd14919     2 SVLHNLKERYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVEMYKGKKRHEMPPHIYAITDTAYRSMMQDREDQSILCTGE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  182 SGAGKTVNTKRVIQYFATVAVQGPEKKKeqasgkmQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTSGK 261
Cdd:cd14919    82 SGAGKTENTKKVIQYLAHVASSHKSKKD-------QGELERQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNGY 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  262 LASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPEL-IEMTLITTNPYDFpmCSQGQITVASIDDKEELVATDTAI 340
Cdd:cd14919   155 IVGANIETYLLEKSRAIRQAKEERTFHIFYYLLSGAGEHLkTDLLLEPYNKYRF--LSNGHVTIPGQQDKDMFQETMEAM 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  341 DILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQREEQAE-PDGTeEADKIGYLLGLNSADMLKALCYPRVKVGNEFVTKGQ 419
Cdd:cd14919   233 RIMGIPEEEQMGLLRVISGVLQLGNIVFKKERNTDQASmPDNT-AAQKVSHLLGINVTDFTRGILTPRIKVGRDYVQKAQ 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  420 TVPQVYNSVSALSKSIYERMFLWMVVRINQMLD-TKQQRNFFIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFNHHMF 498
Cdd:cd14919   312 TKEQADFAIEALAKATYERMFRWLVLRINKALDkTKRQGASFIGILDIAGFEIFDLNSFEQLCINYTNEKLQQLFNHTMF 391
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  499 VLEQEEYKKEGIVWEFIDFGMDLAACIELIEKPL---GIFSILEEECMFPKATDTSFKNKLYdQHLGKCNAFQKPKPAKG 575
Cdd:cd14919   392 ILEQEEYQREGIEWNFIDFGLDLQPCIDLIEKPAgppGILALLDEECWFPKATDKSFVEKVV-QEQGTHPKFQKPKQLKD 470
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  576 KAEahFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYPPV-----------VEETGGGKKGGKKKGG 644
Cdd:cd14919   471 KAD--FCIIHYAGKVDYKADEWLMKNMDPLNDNIATLLHQSSDKFVSELWKDVdriigldqvagMSETALPGAFKTRKGM 548
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  645 sMQTVSSQFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRY 724
Cdd:cd14919   549 -FRTVGQLYKEQLAKLMATLRNTNPNFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRVVFQEFRQRY 627
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....
gi 288856329  725 KVLNASVIPEGqFIDNKKASEKLLGSIDVNHDEYRFGHTKVFFK 768
Cdd:cd14919   628 EILTPNSIPKG-FMDGKQACVLMIKALELDSNLYRIGQSKVFFR 670
MYSc_Myh14_mammals cd14930
class II myosin heavy chain 14 motor domain; Myosin motor domain of non-muscle myosin heavy ...
102-768 0e+00

class II myosin heavy chain 14 motor domain; Myosin motor domain of non-muscle myosin heavy chain 14 (also called FLJ13881, KIAA2034, MHC16, MYH17). Its members include mammals, chickens, and turtles. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. Some of the data used for this classification were produced by the CyMoBase team at the Max-Planck-Institute for Biophysical Chemistry. The sequence names are composed of the species abbreviation followed by the protein abbreviation and optional protein classifier and variant designations.


Pssm-ID: 276893 [Multi-domain]  Cd Length: 670  Bit Score: 635.60  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  102 SVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLITGE 181
Cdd:cd14930     2 SVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPHVYAVTEGAYRSMLQDREDQSILCTGE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  182 SGAGKTVNTKRVIQYFATVAvQGPEKKKEQAsgkMQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTSGK 261
Cdd:cd14930    82 SGAGKTENTKKVIQYLAHVA-SSPKGRKEPG---VPGELERQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVAGY 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  262 LASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPEL-IEMTLITTNPYDF----PMCSQGQitvasidDKEELVAT 336
Cdd:cd14930   158 IVGANIETYLLEKSRAIRQAKDECSFHIFYQLLGGAGEQLkADLLLEPCSHYRFltngPSSSPGQ-------ERELFQET 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  337 DTAIDILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQREEQAE-PDGTeEADKIGYLLGLNSADMLKALCYPRVKVGNEFV 415
Cdd:cd14930   231 LESLRVLGFSHEEITSMLRMVSAVLQFGNIVLKRERNTDQATmPDNT-AAQKLCRLLGLGVTDFSRALLTPRIKVGRDYV 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  416 TKGQTVPQVYNSVSALSKSIYERMFLWMVVRINQMLD-TKQQRNFFIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFN 494
Cdd:cd14930   310 QKAQTKEQADFALEALAKATYERLFRWLVLRLNRALDrSPRQGASFLGILDIAGFEIFQLNSFEQLCINYTNEKLQQLFN 389
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  495 HHMFVLEQEEYKKEGIVWEFIDFGMDLAACIELIEKPL---GIFSILEEECMFPKATDTSFKNKLyDQHLGKCNAFQKPK 571
Cdd:cd14930   390 HTMFVLEQEEYQREGIPWTFLDFGLDLQPCIDLIERPAnppGLLALLDEECWFPKATDKSFVEKV-AQEQGGHPKFQRPR 468
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  572 PAKGKAEahFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYPPV--------VEETGGGKKGGKKKG 643
Cdd:cd14930   469 HLRDQAD--FSVLHYAGKVDYKANEWLMKNMDPLNDNVAALLHQSTDRLTAEIWKDVegivgleqVSSLGDGPPGGRPRR 546
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  644 GSMQTVSSQFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQR 723
Cdd:cd14930   547 GMFRTVGQLYKESLSRLMATLSNTNPSFVRCIVPNHEKRAGKLEPRLVLDQLRCNGVLEGIRICRQGFPNRILFQEFRQR 626
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*
gi 288856329  724 YKVLNASVIPEGqFIDNKKASEKLLGSIDVNHDEYRFGHTKVFFK 768
Cdd:cd14930   627 YEILTPNAIPKG-FMDGKQACEKMIQALELDPNLYRVGQSKIFFR 670
MYSc_Myo7 cd01381
class VII myosin, motor domain; These monomeric myosins have been associated with functions in ...
102-768 0e+00

class VII myosin, motor domain; These monomeric myosins have been associated with functions in sensory systems such as vision and hearing. Mammalian myosin VII has a tail with 2 MyTH4 domains, 2 FERM domains, and a SH3 domain. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276832  Cd Length: 648  Bit Score: 616.57  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  102 SVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLITGE 181
Cdd:cd01381     2 GILRNLLIRYREKLIYTYTGSILVAVNPYQILPIYTAEQIRLYRNKKIGELPPHIFAIADNAYTNMKRNKRDQCVVISGE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  182 SGAGKTVNTKRVIQYFATVavqgpekkkeqaSGKmQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTSGK 261
Cdd:cd01381    82 SGAGKTESTKLILQYLAAI------------SGQ-HSWIEQQILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFNKNGV 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  262 LASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPELIEMtLITTNPYDFPMCSQGQ-ITVASIDDKEELVATDTAI 340
Cdd:cd01381   149 IEGAKIEQYLLEKSRIVSQAPDERNYHIFYCMLAGLSAEEKKK-LELGDASDYYYLTQGNcLTCEGRDDAAEFADIRSAM 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  341 DILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQRE--EQAEPDGTEEADKIGYLLGLNSADMLKALCYPRVKVGNEFVTKG 418
Cdd:cd01381   228 KVLMFTDEEIWDIFKLLAAILHLGNIKFEATVVDnlDASEVRDPPNLERAAKLLEVPKQDLVDALTTRTIFTRGETVVSP 307
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  419 QTVPQVYNSVSALSKSIYERMFLWMVVRIN----QMLDTKQQRNfFIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFN 494
Cdd:cd01381   308 LSAEQALDVRDAFVKGIYGRLFIWIVNKINsaiyKPRGTDSSRT-SIGVLDIFGFENFEVNSFEQLCINFANENLQQFFV 386
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  495 HHMFVLEQEEYKKEGIVWEFIDFgMDLAACIELI-EKPLGIFSILEEECMFPKATDTSFKNKLYDQHLGKCNaFQKPkpa 573
Cdd:cd01381   387 RHIFKLEQEEYDKEGINWQHIEF-VDNQDVLDLIaLKPMNIMSLIDEESKFPKGTDQTMLEKLHSTHGNNKN-YLKP--- 461
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  574 KGKAEAHFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYPPVVEETGGGKKGGkkkggsmQTVSSQF 653
Cdd:cd01381   462 KSDLNTSFGINHFAGVVFYDTRGFLEKNRDTFSADLLQLVQSSKNKFLKQLFNEDISMGSETRKKS-------PTLSSQF 534
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  654 RENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLnASVIP 733
Cdd:cd01381   535 RKSLDQLMKTLSACQPFFVRCIKPNEYKKPMLFDRELCVRQLRYSGMMETIRIRKAGYPIRHTFEEFVERYRVL-VPGIP 613
                         650       660       670
                  ....*....|....*....|....*....|....*
gi 288856329  734 EGQFIDNKKASEKLLGSIDVNHDEYRFGHTKVFFK 768
Cdd:cd01381   614 PAHKTDCRAATRKICCAVLGGDADYQLGKTKIFLK 648
MYSc_Myo1 cd01378
class I myosin, motor domain; Myosin I generates movement at the leading edge in cell motility, ...
102-768 0e+00

class I myosin, motor domain; Myosin I generates movement at the leading edge in cell motility, and class I myosins have been implicated in phagocytosis and vesicle transport. Myosin I, an unconventional myosin, does not form dimers. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. There are 5 myosin subclasses with subclasses c/h, d/g, and a/b have an IQ domain and a TH1 domain. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276829  Cd Length: 652  Bit Score: 606.46  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  102 SVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLITGE 181
Cdd:cd01378     2 AINENLKKRFENDEIYTYIGHVLISVNPFKDLGIYTDEVLESYRGKNRYEVPPHVFALADSAYRNMKSEKENQCVIISGE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  182 SGAGKTVNTKRVIQYFATVavqgpekkkeqaSGKMQGSLE---DQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGT 258
Cdd:cd01378    82 SGAGKTEASKRIMQYIAAV------------SGGSESEVErvkDMLLASNPLLEAFGNAKTLRNDNSSRFGKYMEIQFDF 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  259 SGKLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPELIEMTLITTNPYDFPMCSQGQITVASIDDKEELVATDT 338
Cdd:cd01378   150 KGEPVGGHITNYLLEKSRVVGQIKGERNFHIFYQLLKGASQEYLQELGLQRPEQYYYYSKSGCFDVDGIDDAADFKEVLN 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  339 AIDILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQREEQAEPDgTEEADKIGYLLGLNSADMLKALCYPRVKVGNEF---V 415
Cdd:cd01378   230 AMKVIGFTEEEQDSIFRILAAILHLGNIQFAEDEEGNAAISD-TSVLDFVAYLLGVDPDQLEKALTHRTIETGGGGrsvY 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  416 TKGQTVPQVYNSVSALSKSIYERMFLWMVVRINQMLDTKQQR-NFFIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFN 494
Cdd:cd01378   309 EVPLNVEQAAYARDALAKAIYSRLFDWIVERINKSLAAKSGGkKKVIGVLDIYGFEIFEKNSFEQFCINYVNEKLQQIFI 388
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  495 HhmFVL--EQEEYKKEGIVWEFIDFgMDLAACIELIE-KPLGIFSILEEECMFP-KATDTSFKNKLyDQHLGKCNAFQKP 570
Cdd:cd01378   389 E--LTLkaEQEEYVREGIEWTPIKY-FNNKIICDLIEeKPPGIFAILDDACLTAgDATDQTFLQKL-NQLFSNHPHFECP 464
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  571 KPAKGKAEAHFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYPPVVEETGGGKKGgkkkggsmqTVS 650
Cdd:cd01378   465 SGHFELRRGEFRIKHYAGDVTYNVEGFLDKNKDLLFKDLKELMQSSSNPFLRSLFPEGVDLDSKKRPP---------TAG 535
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  651 SQFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNAS 730
Cdd:cd01378   536 TKFKNSANALVETLMKKQPSYIRCIKPNDNKSPGEFDEELVLHQVKYLGLLENVRVRRAGFAYRQTYEKFLERYKLLSPK 615
                         650       660       670
                  ....*....|....*....|....*....|....*...
gi 288856329  731 VIPEGQFIDnKKASEKLLGSIDVNHDEYRFGHTKVFFK 768
Cdd:cd01378   616 TWPAWDGTW-QGGVESILKDLNIPPEEYQMGKTKIFIR 652
MYSc_Myo8 cd01383
class VIII myosin, motor domain; These plant-specific type VIII myosins has been associated ...
101-768 0e+00

class VIII myosin, motor domain; These plant-specific type VIII myosins has been associated with endocytosis, cytokinesis, cell-to-cell coupling and gating at plasmodesmata. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. It also contains IQ domains Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276834  Cd Length: 647  Bit Score: 605.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  101 PSVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRgKKRMEaPPHIFSVSDNAYQFMLTDRENQSVLITG 180
Cdd:cd01383     1 PSVLHNLEYRYSQDIIYTKAGPVLIAVNPFKDVPLYGNEFITAYR-QKLLD-SPHVYAVADTAYREMMRDEINQSIIISG 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  181 ESGAGKTVNTKRVIQYFATVavqgpekkkeqasGKMQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTSG 260
Cdd:cd01383    79 ESGAGKTETAKIAMQYLAAL-------------GGGSSGIENEILQTNPILEAFGNAKTLRNDNSSRFGKLIDIHFDAAG 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  261 KLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPELIEmTLITTNPYDFPMCSQGQ-ITVASIDDKEELVATDTA 339
Cdd:cd01383   146 KICGAKIQTYLLEKSRVVQLANGERSYHIFYQLCAGASPALRE-KLNLKSASEYKYLNQSNcLTIDGVDDAKKFHELKEA 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  340 IDILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQREEQAEPDGTEEADKIGYLLGLNSADMLKALCYPRVKVGNEFVTKGQ 419
Cdd:cd01383   225 LDTVGISKEDQEHIFQMLAAVLWLGNISFQVIDNENHVEVVADEAVSTAASLLGCNANDLMLALSTRKIQAGGDKIVKKL 304
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  420 TVPQVYNSVSALSKSIYERMFLWMVVRINQMLDTKQQRNF-FIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFNHHMF 498
Cdd:cd01383   305 TLQQAIDARDALAKAIYASLFDWLVEQINKSLEVGKRRTGrSISILDIYGFESFQKNSFEQLCINYANERLQQHFNRHLF 384
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  499 VLEQEEYKKEGIVWEFIDFgMDLAACIELIE-KPLGIFSILEEECMFPKATDTSFKNKLyDQHLGKCNAFqkpkpaKGKA 577
Cdd:cd01383   385 KLEQEEYELDGIDWTKVDF-EDNQECLDLIEkKPLGLISLLDEESNFPKATDLTFANKL-KQHLKSNSCF------KGER 456
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  578 EAHFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYPPVVEE-TGGGKKGGKKKGGSM-QTVSSQFRE 655
Cdd:cd01383   457 GGAFTIRHYAGEVTYDTSGFLEKNRDLLHSDLIQLLSSCSCQLPQLFASKMLDAsRKALPLTKASGSDSQkQSVATKFKG 536
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  656 NLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLnasvIPEG 735
Cdd:cd01383   537 QLFKLMQRLENTTPHFIRCIKPNNKQLPGVFDQDLVLQQLRCCGVLEVVRISRSGYPTRMTHQEFARRYGFL----LPED 612
                         650       660       670
                  ....*....|....*....|....*....|....*
gi 288856329  736 QFIDNKKASEK--LLGSIDVNHDEYRFGHTKVFFK 768
Cdd:cd01383   613 VSASQDPLSTSvaILQQFNILPEMYQVGYTKLFFR 647
MYSc_Myo22 cd14883
class XXII myosin, motor domain; These myosins possess an extended neck with multiple IQ ...
102-768 0e+00

class XXII myosin, motor domain; These myosins possess an extended neck with multiple IQ motifs such as found in class V, VIII, XI, and XIII myosins. These myosins are defined by two tandem MyTH4 and FERM domains. The apicomplexan, but not diatom myosins contain 4-6 WD40 repeats near the end of the C-terminal tail which suggests a possible function of these myosins in signal transduction and transcriptional regulation. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276849 [Multi-domain]  Cd Length: 661  Bit Score: 590.84  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  102 SVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLITGE 181
Cdd:cd14883     2 GINTNLKVRYKKDLIYTYTGSILVAVNPYKELPIYTQDIVKQYFGKRMGALPPHIFALAEAAYTNMQEDGKNQSVIISGE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  182 SGAGKTVNTKRVIQYFATVAVQgpekkkeqasgkmQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTSGK 261
Cdd:cd14883    82 SGAGKTETTKLILQYLCAVTNN-------------HSWVEQQILEANTILEAFGNAKTVRNDNSSRFGKFIEVCFDASGH 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  262 LASADIETYLLEKSRVTFQLPDERGYHIFYQMMT--NHKPELIEmTLITTNPYDFPMCSQ-GQITVASIDDKEELVATDT 338
Cdd:cd14883   149 IKGAIIQDYLLEQSRITFQAPGERNYHVFYQLLAgaKHSKELKE-KLKLGEPEDYHYLNQsGCIRIDNINDKKDFDHLRL 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  339 AIDILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQREEQAE-PDGTEEADKIGYLLGLNSADMLKALCYPRVKVGNEFVTK 417
Cdd:cd14883   228 AMNVLGIPEEMQEGIFSVLSAILHLGNLTFEDIDGETGALtVEDKEILKIVAKLLGVDPDKLKKALTIRQINVRGNVTEI 307
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  418 GQTVPQVYNSVSALSKSIYERMFLWMVVRINQMLDTKQQRNFFIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFNHHM 497
Cdd:cd14883   308 PLKVQEARDNRDAMAKALYSRTFAWLVNHINSCTNPGQKNSRFIGVLDIFGFENFKVNSFEQLCINYTNEKLHKFFNHYV 387
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  498 FVLEQEEYKKEGIVWEFIDFgMDLAACIELIEK-PLGIFSILEEECMFPKATDTSFKNKLYDQHlGKCNAFQkpKPAKGK 576
Cdd:cd14883   388 FKLEQEEYEKEGINWSHIVF-TDNQECLDLIEKpPLGILKLLDEECRFPKGTDLTYLEKLHAAH-EKHPYYE--KPDRRR 463
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  577 AEAHFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLY-PPVVEETGGGKKGGKKKGGSMQ------TV 649
Cdd:cd14883   464 WKTEFGVKHYAGEVTYTVQGFLDKNKDTQQDDLFDLMSRSKNKFVKELFtYPDLLALTGLSISLGGDTTSRGtskgkpTV 543
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  650 SSQFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNa 729
Cdd:cd14883   544 GDTFKHQLQSLVDVLSATQPWYVRCIKPNSLKEPNVFDDELVLAQLRYAGMLEIIRIRKEGFPIHLTFKEFVDRYLCLD- 622
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|..
gi 288856329  730 sviPEGQFIDNKKASE---KLLGSIDVNHDEYRFGHTKVFFK 768
Cdd:cd14883   623 ---PRARSADHKETCGavrALMGLGGLPEDEWQVGKTKVFLR 661
MYSc_Myo11 cd01384
class XI myosin, motor domain; These plant-specific type XI myosin are involved in organelle ...
101-768 0e+00

class XI myosin, motor domain; These plant-specific type XI myosin are involved in organelle transport. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle.


Pssm-ID: 276835  Cd Length: 647  Bit Score: 576.94  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  101 PSVLYNLKERYAAWMIYTYSGLFCATVNPYKWLP-VYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLIT 179
Cdd:cd01384     1 PGVLHNLKVRYELDEIYTYTGNILIAVNPFKRLPhLYDAHMMEQYKGAPLGELSPHVFAVADAAYRAMINEGKSQSILVS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  180 GESGAGKTVNTKRVIQYFATVAvqgpekKKEQASGKmqgSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTS 259
Cdd:cd01384    81 GESGAGKTETTKMLMQYLAYMG------GRAVTEGR---SVEQQVLESNPLLEAFGNAKTVRNNNSSRFGKFVEIQFDDA 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  260 GKLASADIETYLLEKSRVTfQLPD-ERGYHIFYQMMTNHKPELIEmTLITTNPYDFPMCSQGQ-ITVASIDDKEELVATD 337
Cdd:cd01384   152 GRISGAAIRTYLLERSRVV-QVSDpERNYHCFYQLCAGAPPEDRE-KYKLKDPKQFHYLNQSKcFELDGVDDAEEYRATR 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  338 TAIDILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQREEQAEP--DGTEEADKI-GYLLGLNSADMLKALCYPRVKVGNEF 414
Cdd:cd01384   230 RAMDVVGISEEEQDAIFRVVAAILHLGNIEFSKGEEDDSSVPkdEKSEFHLKAaAELLMCDEKALEDALCKRVIVTPDGI 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  415 VTKGQTVPQVYNSVSALSKSIYERMFLWMVVRINQMLDTKQQRNFFIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFN 494
Cdd:cd01384   310 ITKPLDPDAATLSRDALAKTIYSRLFDWLVDKINRSIGQDPNSKRLIGVLDIYGFESFKTNSFEQFCINLANEKLQQHFN 389
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  495 HHMFVLEQEEYKKEGIVWEFIDFgMDLAACIELIE-KPLGIFSILEEECMFPKATDTSFKNKLYDQhlGKCNA-FQKPKp 572
Cdd:cd01384   390 QHVFKMEQEEYTKEEIDWSYIEF-VDNQDVLDLIEkKPGGIIALLDEACMFPRSTHETFAQKLYQT--LKDHKrFSKPK- 465
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  573 akgKAEAHFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYPPVVEEtgggkkgGKKKGGSMQTVSSQ 652
Cdd:cd01384   466 ---LSRTDFTIDHYAGDVTYQTDLFLDKNKDYVVAEHQALLNASKCPFVAGLFPPLPRE-------GTSSSSKFSSIGSR 535
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  653 FRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLnASVI 732
Cdd:cd01384   536 FKQQLQELMETLNTTEPHYIRCIKPNNLLKPGIFENANVLQQLRCGGVLEAVRISCAGYPTRKPFEEFLDRFGLL-APEV 614
                         650       660       670
                  ....*....|....*....|....*....|....*.
gi 288856329  733 PEGQFiDNKKASEKLLGSIDVNhdEYRFGHTKVFFK 768
Cdd:cd01384   615 LKGSD-DEKAACKKILEKAGLK--GYQIGKTKVFLR 647
MYSc_Myo6 cd01382
class VI myosin, motor domain; Myosin VI is a monomeric myosin, which moves towards the ...
101-768 4.45e-165

class VI myosin, motor domain; Myosin VI is a monomeric myosin, which moves towards the minus-end of actin filaments, in contrast to most other myosins which moves towards the plus-end of actin filaments. It is thought that myosin VI, unlike plus-end directed myosins, does not use a pure lever arm mechanism, but instead steps with a mechanism analogous to the kinesin neck-linker uncoupling model. It has been implicated in a myriad of functions including: the transport of cytoplasmic organelles, maintenance of normal Golgi morphology, endocytosis, secretion, cell migration, border cell migration during development, and in cancer metastasis playing roles in deafness and retinal development among others. While how this is accomplished is largely unknown there are several interacting proteins that have been identified such as disabled homolog 2 (DAB2), GIPC1, synapse-associated protein 97 (SAP97; also known as DLG1) and optineurin, which have been found to target myosin VI to different cellular compartments. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the minus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276833  Cd Length: 649  Bit Score: 519.88  E-value: 4.45e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  101 PSVLYNLKERYAAWMIYTYSGLFCATVNPYKWLP-VYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLIT 179
Cdd:cd01382     1 ATLLNNIRVRYSKDKIYTYVANILIAVNPYFDIPkLYSSETIKSYQGKSLGTLPPHVFAIADKAYRDMKVLKQSQSIIVS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  180 GESGAGKTVNTKRVIQYFATVAvqgpekkkeqasGKMQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTS 259
Cdd:cd01382    81 GESGAGKTESTKYILRYLTESW------------GSGAGPIEQRILEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEK 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  260 GKLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPELIEMTLittnpydfpmcsqgqiTVASIDDKEELVATDTA 339
Cdd:cd01382   149 SSVVGGFVSHYLLEKSRICVQSKEERNYHIFYRLCAGAPEDLREKLL----------------KDPLLDDVGDFIRMDKA 212
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  340 IDILGFNNEEKMGIYKFTGAVLHHGNMKFkqkqrEEQAE--------PDGTEEADKI-GYLLGLNSADMLKALCYpRVKV 410
Cdd:cd01382   213 MKKIGLSDEEKLDIFRVVAAVLHLGNIEF-----EENGSdsgggcnvKPKSEQSLEYaAELLGLDQDELRVSLTT-RVMQ 286
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  411 GNEFVTKGQ--TVP----QVYNSVSALSKSIYERMFLWMVVRINQMLDTkQQRNFFIGVLDIAGFEIFDFNSMEQLCINF 484
Cdd:cd01382   287 TTRGGAKGTviKVPlkveEANNARDALAKAIYSKLFDHIVNRINQCIPF-ETSSYFIGVLDIAGFEYFEVNSFEQFCINY 365
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  485 TNEKLQQFFNHHMFVLEQEEYKKEGIVWEFIDFgMDLAACIELIE-KPLGIFSILEEECMFPKATDTSFKNKLYDQHLgk 563
Cdd:cd01382   366 CNEKLQQFFNERILKEEQELYEKEGLGVKEVEY-VDNQDCIDLIEaKLVGILDLLDEESKLPKPSDQHFTSAVHQKHK-- 442
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  564 cNAFQKPKPAKGKAEAH--------FSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYPPvvEETGGG 635
Cdd:cd01382   443 -NHFRLSIPRKSKLKIHrnlrddegFLIRHFAGAVCYETAQFIEKNNDALHASLESLICESKDKFIRSLFES--STNNNK 519
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  636 KKGGKKKGGSMQTVSSQFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRI 715
Cdd:cd01382   520 DSKQKAGKLSFISVGNKFKTQLNLLMDKLRSTGTSFIRCIKPNLKMTSHHFEGAQILSQLQCSGMVSVLDLMQGGFPSRT 599
                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|....
gi 288856329  716 LYADFKQRYKvlnaSVIPEG-QFIDNKKASEKLLGSIDVNHDEYRFGHTKVFFK 768
Cdd:cd01382   600 SFHDLYNMYK----KYLPPKlARLDPRLFCKALFKALGLNENDFKFGLTKVFFR 649
MYSc_Myo29 cd14890
class XXIX myosin, motor domain; Class XXIX myosins are comprised of Stramenopiles and have ...
102-768 2.57e-164

class XXIX myosin, motor domain; Class XXIX myosins are comprised of Stramenopiles and have very long tail domains consisting of three IQ motifs, short coiled-coil regions, up to 18 CBS domains, a PB1 domain, and a carboxy-terminal transmembrane domain. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276855 [Multi-domain]  Cd Length: 662  Bit Score: 518.18  E-value: 2.57e-164
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  102 SVLYNLKERYAAWMIYTYSGLFCATVNPYKWLP-VYDAEVVAAYRGKKRMEAPPHIFSVSDNAY-QFM---LTDRENQSV 176
Cdd:cd14890     2 SLLHTLRLRYERDEIYTYVGPILISINPYKSIPdLYSEERMLLYHGTTAGELPPHVFAIADHAYtQLIqsgVLDPSNQSI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  177 LITGESGAGKTVNTKRVIQYFATV----AVQGPEKKKEQASGKMQ--GSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGK 250
Cdd:cd14890    82 IISGESGAGKTEATKIIMQYLARItsgfAQGASGEGEAASEAIEQtlGSLEDRVLSSNPLLESFGNAKTLRNDNSSRFGK 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  251 FIRIHFGTSGKLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPELIEmTLITTNPYDFPMCSQGQITVASIDDK 330
Cdd:cd14890   162 FIEIQFDHHGKIVGAEISNFLLEKTRIVTQNDGERNYHIFYQLLAGADEALRE-RLKLQTPVEYFYLRGECSSIPSCDDA 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  331 EELVATDTAIDILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQREEQAEPDGTEEA-DKIGYLLGLNSADMLKALCYPRVK 409
Cdd:cd14890   241 KAFAETIRCLSTIGISEENQDAVFGLLAAVLHLGNVDFESENDTTVLEDATTLQSlKLAAELLGVNEDALEKALLTRQLF 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  410 VGNEFVTKGQTVPQVYNSVSALSKSIYERMFLWMVVRINQMLDTKQQRNFFIGVLDIAGFEIFDFNSMEQLCINFTNEKL 489
Cdd:cd14890   321 VGGKTIVQPQNVEQARDKRDALAKALYSSLFLWLVSELNRTISSPDDKWGFIGVLDIYGFEKFEWNTFEQLCINYANEKL 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  490 QQFFNHHMFVLEQEEYKKEGIVWEFIDFgMDLAACIELIE-----KPlGIFSILEEECMFPKA-TDTSFKNKLYDQHLGK 563
Cdd:cd14890   401 QRHFNQHMFEVEQVEYSNEGIDWQYITF-NDNQACLELIEgkvngKP-GIFITLDDCWRFKGEeANKKFVSQLHASFGRK 478
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  564 CNAFQKPKPAKGK---------AEAHFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATlyppvveetgg 634
Cdd:cd14890   479 SGSGGTRRGSSQHphfvhpkfdADKQFGIKHYAGDVIYDASGFNEKNNETLNAEMKELIKQSRRSIREV----------- 547
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  635 gkkggkkkggsmqTVSSQFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSR 714
Cdd:cd14890   548 -------------SVGAQFRTQLQELMAKISLTNPRYVRCIKPNETKAPGKFDGLDCLRQLKYSGMMEAIQIRQQGFALR 614
                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 288856329  715 ILYADFKQRYKVLNASVipegqfiDNKKASEKLLGSI-DVNHDEYRFGHTKVFFK 768
Cdd:cd14890   615 EEHDSFFYDFQVLLPTA-------ENIEQLVAVLSKMlGLGKADWQIGSSKIFLK 662
MYSc_Myo42 cd14903
class XLII myosin, motor domain; The class XLII myosins are comprised of Stramenopiles. Not ...
101-768 3.53e-163

class XLII myosin, motor domain; The class XLII myosins are comprised of Stramenopiles. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276868 [Multi-domain]  Cd Length: 658  Bit Score: 515.10  E-value: 3.53e-163
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  101 PSVLYNLKERYAAWMIYTYSGLFCATVNPYKWLP-VYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLIT 179
Cdd:cd14903     1 AAILYNVKKRFLRKLPYTYTGDICIAVNPYQWLPeLYTEEQHSKYLNKPKEELPPHVYATSVAAYNHMKRSGRNQSILVS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  180 GESGAGKTVNTKRVIQYFATVAvqgpekkkeqasGKMQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTS 259
Cdd:cd14903    81 GESGAGKTETTKILMNHLATIA------------GGLNDSTIKKIIEVNPLLESFGNAKTVRNDNSSRFGKFTQLQFDKN 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  260 GKLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPELiEMTLITTNPYDFPmcsqGQITVASID---DKEELVAT 336
Cdd:cd14903   149 GTLVGAKCRTYLLEKTRVISHERPERNYHIFYQLLASPDVEE-RLFLDSANECAYT----GANKTIKIEgmsDRKHFART 223
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  337 DTAIDILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQREEQAE--PDGTEEADKIGYLLGLNSADMLKALCYPRVKVGNEF 414
Cdd:cd14903   224 KEALSLIGVSEEKQEVLFEVLAGILHLGQLQIQSKPNDDEKSaiAPGDQGAVYATKLLGLSPEALEKALCSRTMRAAGDV 303
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  415 VTKGQTVPQVYNSVSALSKSIYERMFLWMVVRINQMLDTKQQRNFFIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFN 494
Cdd:cd14903   304 YTVPLKKDQAEDCRDALAKAIYSNVFDWLVATINASLGNDAKMANHIGVLDIFGFEHFKHNSFEQFCINYANEKLQQKFT 383
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  495 HHMFVLEQEEYKKEGIVWEFIDFgMDLAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQHLGKCNAFQKPKPAK 574
Cdd:cd14903   384 QDVFKTVQIEYEEEGIRWAHIDF-ADNQDVLAVIEDRLGIISLLNDEVMRPKGNEESFVSKLSSIHKDEQDVIEFPRTSR 462
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  575 gkaeAHFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYPPVVEETGGGKKGGKKKGG-------SMQ 647
Cdd:cd14903   463 ----TQFTIKHYAGPVTYESLGFLEKHKDALLPDLSDLMRGSSKPFLRMLFKEKVESPAAASTSLARGARrrrggalTTT 538
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  648 TVSSQFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVL 727
Cdd:cd14903   539 TVGTQFKDSLNELMTTIRSTNVHYVRCIKPNSIKSPTELDHLMVVSQLRCAGVIEAIRISRAAYPNRLLHEEFLDKFWLF 618
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....
gi 288856329  728 nasvIPEGQFIDNKKAS--EKLLGSIDVNH-DEYRFGHTKVFFK 768
Cdd:cd14903   619 ----LPEGRNTDVPVAErcEALMKKLKLESpEQYQMGLTRIYFQ 658
MYSc_Myo4 cd14872
class IV myosin, motor domain; These myosins all possess a WW domain either N-terminal or ...
101-768 6.84e-163

class IV myosin, motor domain; These myosins all possess a WW domain either N-terminal or C-terminal to their motor domain and a tail with a MyTH4 domain followed by a SH3 domain in some instances. The monomeric Acanthamoebas were the first identified members of this group and have been joined by Stramenopiles. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276839  Cd Length: 644  Bit Score: 513.94  E-value: 6.84e-163
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  101 PSVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLITG 180
Cdd:cd14872     1 AMIVHNLRKRFKNDQIYTNVGTILISVNPFKRLPLYTPTVMDQYMHKGPKEMPPHTYNIADDAYRAMIVDAMNQSILISG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  181 ESGAGKTVNTKRVIQYFATVAvqgpekkkeqasgKMQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTSG 260
Cdd:cd14872    81 ESGAGKTEATKQCLSFFAEVA-------------GSTNGVEQRVLLANPILEAFGNAKTLRNNNSSRFGKWVEIHFDNRG 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  261 KLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTnhKPELIEMTLITTNPyDFPMCSQGQ-ITVASIDDKEELVATDTA 339
Cdd:cd14872   148 RICGASTENYLLEKSRVVYQIKGERNFHIFYQLLA--SPDPASRGGWGSSA-AYGYLSLSGcIEVEGVDDVADFEEVVLA 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  340 IDILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQREEQAEPDGT---EEADKIGYLLGLNSADMLKALCYPRVKVGNefvT 416
Cdd:cd14872   225 MEQLGFDDADINNVMSLIAAILKLGNIEFASGGGKSLVSGSTVanrDVLKEVATLLGVDAATLEEALTSRLMEIKG---C 301
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  417 KGQTVP----QVYNSVSALSKSIYERMFLWMVVRINQ-MLDTKQQRNFFIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQ 491
Cdd:cd14872   302 DPTRIPltpaQATDACDALAKAAYSRLFDWLVKKINEsMRPQKGAKTTFIGVLDIFGFEIFEKNSFEQLCINFTNEKLQQ 381
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  492 FFNHHMFVLEQEEYKKEGIVWEFIDFgMDLAACIELIEK-PLGIFSILEEECMFPKATDTSFKNKLYDQHLGKcnAFQKP 570
Cdd:cd14872   382 HFNQYTFKLEEALYQSEGVKFEHIDF-IDNQPVLDLIEKkQPGLMLALDDQVKIPKGSDATFMIAANQTHAAK--STFVY 458
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  571 KPAKGkAEAHFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYPPVveetgggkkgGKKKGGSMQTVS 650
Cdd:cd14872   459 AEVRT-SRTEFIVKHYAGDVTYDITGFLEKNKDTLQKDLYVLLSSSKNKLIAVLFPPS----------EGDQKTSKVTLG 527
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  651 SQFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNAS 730
Cdd:cd14872   528 GQFRKQLSALMTALNATEPHYIRCVKPNQEKRARLFDGFMSLEQLRYAGVFEAVKIRKTGYPFRYSHERFLKRYRFLVKT 607
                         650       660       670
                  ....*....|....*....|....*....|....*...
gi 288856329  731 vIPEGQFIDNKKASEKLLGSIDVNHDEYRFGHTKVFFK 768
Cdd:cd14872   608 -IAKRVGPDDRQRCDLLLKSLKQDFSKVQVGKTRVLYR 644
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
848-1925 4.49e-162

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 526.67  E-value: 4.49e-162
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   848 EKELATMKEDFVKCKEDLAKAEAKKKELEEKMVALLQEKNDLQLAVASESENLSDAEERCEGLIKSKIQLEAKLKETTER 927
Cdd:pfam01576    4 EEEMQAKEEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLQAETELCAEAEEMRARLAARKQELEEILHELESR 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   928 LEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAAQDESIGKLTKEKKALQEAHQQ 1007
Cdd:pfam01576   84 LEEEEERSQQLQNEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLLEDQNSKLSKERKLLEERISE 163
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1008 TLDDLQAEEDKVNTLTKSKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDLENDKQQSEEKLKKKDF 1087
Cdd:pfam01576  164 FTSNLAEEEEKAKSLSKLKNKHEAMISDLEERLKKEEKGRQELEKAKRKLEGESTDLQEQIAELQAQIAELRAQLAKKEE 243
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1088 ETSQLLSKIEDEQSLGAQLQKKIKELQARIEELEEEIEAERAARAKVEKQRADLSRELEEISERLEEAGGATAAQIEMNK 1167
Cdd:pfam01576  244 ELQAALARLEEETAQKNNALKKIRELEAQISELQEDLESERAARNKAEKQRRDLGEELEALKTELEDTLDTTAAQQELRS 323
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1168 KREAEFQKLRRDLEESTLQHEATAAALRKKQADSVAELGEQIDNLQRVKQKLEKEKSEYKMEIDDLSSNMEAVAKAKANL 1247
Cdd:pfam01576  324 KREQEVTELKKALEEETRSHEAQLQEMRQKHTQALEELTEQLEQAKRNKANLEKAKQALESENAELQAELRTLQQAKQDS 403
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1248 EKMCRTLEDQLSEIKSKNDENLRQINDLSAQRARLQTENGEFGRQLEEKEALVSQLTRGKQAFTQQIEELKRQIEEEVKA 1327
Cdd:pfam01576  404 EHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDVSSLESQLQDTQELLQEETRQ 483
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1328 KNALAHAVQSARHDCDLLREQFEEEQEAKAELQRGMSKANSEVAQWRTKYETDAiQRTEELEESKKKLAQRLQEAEEQIE 1407
Cdd:pfam01576  484 KLNLSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLEEDA-GTLEALEEGKKRLQRELEALTQQLE 562
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1408 AVNSKCASLEKTKQRLQGEVEDLMIDVERANALAANLDKKQRNFDKVLAEWKQKYEEGQAELEGAQKEARSLSTELFKMK 1487
Cdd:pfam01576  563 EKAAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNLEKKQKKFDQMLAEEKAISARYAEERDRAEAEAREKETRALSLA 642
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1488 NSYEETLDQLETLKRENKNLQQEISDLTEQLGETGKSIHELEKSKKAVETEKAEIQTALEEAEGTLEHEESKILRVQLEL 1567
Cdd:pfam01576  643 RALEEALEAKEELERTNKQLRAEMEDLVSSKDDVGKNVHELERSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNM 722
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1568 NQVKSEIDRKLAEKDEEIEQIKRNSQRITDSMQSTLDSEVRSRNDALRIKKKMEGDLNEMEIQLSHANRQAAEAQKQLRN 1647
Cdd:pfam01576  723 QALKAQFERDLQARDEQGEEKRRQLVKQVRELEAELEDERKQRAQAVAAKKKLELDLKELEAQIDAANKGREEAVKQLKK 802
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1648 VQAQLKDAQLHLDDAVRGQEDMKEQVAMVERRNTLMQSEIEELRAALEQTERGRKVAEQELVDASERVGLLHSQNTSLLN 1727
Cdd:pfam01576  803 LQAQMKDLQRELEEARASRDEILAQSKESEKKLKNLEAELLQLQEDLAASERARRQAQQERDELADEIASGASGKSALQD 882
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1728 TKKKLEADLVQIQSEVEDTVQEARNAEDKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEVTVKDLQHRLDEAENLAM 1807
Cdd:pfam01576  883 EKRRLEARIAQLEEELEEEQSNTELLNDRLRKSTLQVEQLTTELAAERSTSQKSESARQQLERQNKELKAKLQEMEGTVK 962
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1808 KGGKKQLQKLESRVRELESEVEAEQRRGADAVKGVRKYERRVKELTYQTEEDKKNVNRLQDLVDKLQLKVKAYKRQSEEA 1887
Cdd:pfam01576  963 SKFKSSIAALEAKIAQLEEQLEQESRERQAANKLVRRTEKKLKEVLLQVEDERRHADQYKDQAEKGNSRMKQLKRQLEEA 1042
                         1050      1060      1070
                   ....*....|....*....|....*....|....*...
gi 288856329  1888 EEQANSHLSKLRKVQHELEEAEERADIAESQVNKLRAK 1925
Cdd:pfam01576 1043 EEEASRANAARRKLQRELDDATESNESMNREVSTLKSK 1080
MYSc_Myo27 cd14888
class XXVII myosin, motor domain; Not much is known about this myosin class. The catalytic ...
101-768 3.37e-161

class XXVII myosin, motor domain; Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276853 [Multi-domain]  Cd Length: 667  Bit Score: 510.00  E-value: 3.37e-161
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  101 PSVLYNLKERYAAWMIYTYSGLFCATVNPYKWLP-VYDAEVVAAYRgKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLIT 179
Cdd:cd14888     1 ASILHSLNLRFDIDEIYTFTGPILIAVNPFKTIPgLYSDEMLLKFI-QPSISKSPHVFSTASSAYQGMCNNKKSQTILIS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  180 GESGAGKTVNTKRVIQYfatVAVQGPEKKKeqasgkMQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHF--- 256
Cdd:cd14888    80 GESGAGKTESTKYVMKF---LACAGSEDIK------KRSLVEAQVLESNPLLEAFGNARTLRNDNSSRFGKFIELQFskl 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  257 ------GTSGKLASADIETYLLEKSRVTFQLPDERGYHIFYQ--------------MMTNH---------KPELIEMTLi 307
Cdd:cd14888   151 kskrmsGDRGRLCGAKIQTYLLEKVRVCDQQEGERNYHIFYQlcaaareakntglsYEENDeklakgadaKPISIDMSS- 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  308 ttnpyDFPMCSQGQITVASI------DDKEELVATDTAIDILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQREEQA---E 378
Cdd:cd14888   230 -----FEPHLKFRYLTKSSChelpdvDDLEEFESTLYAMQTVGISPEEQNQIFSIVAAILYLGNILFENNEACSEGavvS 304
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  379 PDGTEEADKIGYLLGLNSADMLKALCYPRVKVGNEFVTKGQTVPQVYNSVSALSKSIYERMFLWMVVRINQMLD-TKQQR 457
Cdd:cd14888   305 ASCTDDLEKVASLLGVDAEDLLNALCYRTIKTAHEFYTKPLRVDEAEDVRDALARALYSCLFDKVVERTNESIGySKDNS 384
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  458 NFFIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIVWEFIDFGmDLAACIELI-EKPLGIFS 536
Cdd:cd14888   385 LLFCGVLDIFGFECFQLNSFEQLCINFTNERLQQFFNNFVFKCEEKLYIEEGISWNPLDFP-DNQDCVDLLqEKPLGIFC 463
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  537 ILEEECMFPKATDTSFKNKLYDQHLGKcNAFQKPKpakgKAEAHFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKS 616
Cdd:cd14888   464 MLDEECFVPGGKDQGLCNKLCQKHKGH-KRFDVVK----TDPNSFVIVHFAGPVKYCSDGFLEKNKDQLSVDAQEVIKNS 538
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  617 SVKLLATLYPPVVEETGGGKKGGKKKggsmQTVSSQFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLR 696
Cdd:cd14888   539 KNPFISNLFSAYLRRGTDGNTKKKKF----VTVSSEFRNQLDVLMETIDKTEPHFIRCIKPNSQNVPDLFDRISVNEQLK 614
                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 288856329  697 CNGVLEGIRICRKGFPSRILYADFKQRYKVLnasvipegqfidnkkasekLLGSIDVNHDEYRFGHTKVFFK 768
Cdd:cd14888   615 YGGVLQAVQVSRAGYPVRLSHAEFYNDYRIL-------------------LNGEGKKQLSIWAVGKTLCFFK 667
MYSc_Myo15 cd01387
class XV mammal-like myosin, motor domain; The class XV myosins are monomeric. In vertebrates, ...
102-768 8.92e-158

class XV mammal-like myosin, motor domain; The class XV myosins are monomeric. In vertebrates, myosin XV appears to be expressed in sensory tissue and play a role in hearing. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. C-terminal to the head domain are 2 MyTH4 domain, a FERM domain, and a SH3 domain. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276838 [Multi-domain]  Cd Length: 657  Bit Score: 500.43  E-value: 8.92e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  102 SVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLITGE 181
Cdd:cd01387     2 TVLWNLKTRYERNLIYTYIGSILVSVNPYKMFDIYGLEQVQQYSGRALGELPPHLFAIANLAFAKMLDAKQNQCVVISGE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  182 SGAGKTVNTKRVIQYFATVAVQGPEKKKEQasgkmqgsledqIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFgTSGK 261
Cdd:cd01387    82 SGSGKTEATKLIMQYLAAVNQRRNNLVTEQ------------ILEATPLLEAFGNAKTVRNDNSSRFGKYLEVFF-EGGV 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  262 LASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPELIE-MTLITTNPYdFPMCSQGQITVASIDDKEELVATDTAI 340
Cdd:cd01387   149 IVGAITSQYLLEKSRIVTQAKNERNYHVFYELLAGLPAQLRQkYGLQEAEKY-FYLNQGGNCEIAGKSDADDFRRLLAAM 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  341 DILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQRE---EQAEPDGTEEADKIGYLLGLNSADMLKALCYPRVKVGNEFVTK 417
Cdd:cd01387   228 QVLGFSSEEQDSIFRILASVLHLGNVYFHKRQLRhgqEGVSVGSDAEIQWVAHLLQISPEGLQKALTFKVTETRRERIFT 307
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  418 GQTVPQVYNSVSALSKSIYERMFLWMVVRINQMLDTKQQRNFFIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFNHHM 497
Cdd:cd01387   308 PLTIDQALDARDAIAKALYALLFSWLVTRVNAIVYSGTQDTLSIAILDIFGFEDLSENSFEQLCINYANENLQYYFNKHV 387
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  498 FVLEQEEYKKEGIVWEFIDFgMDLAACIELI-EKPLGIFSILEEECMFPKATDTSFKNKLYDQHlGKCNAFQKPKpaKGK 576
Cdd:cd01387   388 FKLEQEEYIREQIDWTEIAF-ADNQPVINLIsKKPVGILHILDDECNFPQATDHSFLEKCHYHH-ALNELYSKPR--MPL 463
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  577 AEahFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYPPVVEETGGGKKGGKK-KGGSMQ----TVSS 651
Cdd:cd01387   464 PE--FTIKHYAGQVWYQVHGFLDKNRDQLRQDVLELLVSSRTRVVAHLFSSHRAQTDKAPPRLGKgRFVTMKprtpTVAA 541
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  652 QFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASV 731
Cdd:cd01387   542 RFQDSLLQLLEKMERCNPWFVRCLKPNHKKEPMLFDMDVVMAQLRYSGMLETIRIRKEGYPVRLPFQVFIDRYRCLVALK 621
                         650       660       670
                  ....*....|....*....|....*....|....*..
gi 288856329  732 IPEGQFIDNKKASEKLLGSIdVNHDEYRFGHTKVFFK 768
Cdd:cd01387   622 LPRPAPGDMCVSLLSRLCTV-TPKDMYRLGATKVFLR 657
MYSc_Myo40 cd14901
class XL myosin, motor domain; The class XL myosins are comprised of Stramenopiles. Not much ...
101-766 2.60e-154

class XL myosin, motor domain; The class XL myosins are comprised of Stramenopiles. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276866 [Multi-domain]  Cd Length: 655  Bit Score: 490.84  E-value: 2.60e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  101 PSVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAY--RGKKRM----EAPPHIFSVSDNAYQFMLTDRE-- 172
Cdd:cd14901     1 PSILHVLRRRFAHGLIYTSTGAILVAINPFRRLPLYDDETKEAYyeHGERRAagerKLPPHVYAVADKAFRAMLFASRgq 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  173 --NQSVLITGESGAGKTVNTKRVIQYFATVAvqgpEKKKEQASGKMQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGK 250
Cdd:cd14901    81 kcDQSILVSGESGAGKTETTKIIMNYLASVS----SATTHGQNATERENVRDRVLESNPILEAFGNARTNRNNNSSRFGK 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  251 FIRIHFGTSGKLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKP-ELIEMTLITTNPYDFPMCSQGQITVASIDD 329
Cdd:cd14901   157 FIRLGFASSGSLLGASISTYLLERVRLVSQAKGERNYHIFYELLRGASSdELHALGLTHVEEYKYLNSSQCYDRRDGVDD 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  330 KEELVATDTAIDILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQREEQAEPDGTE-EADKIGYLLGLNSADMLKALCYPRV 408
Cdd:cd14901   237 SVQYAKTRHAMTTIGMSPDEQISVLQLVAAVLHLGNLCFVKKDGEGGTFSMSSLaNVRAACDLLGLDMDVLEKTLCTREI 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  409 KVGNEFVTKGQTVPQVYNSVSALSKSIYERMFLWMVVRINQML----DTKQQRnfFIGVLDIAGFEIFDFNSMEQLCINF 484
Cdd:cd14901   317 RAGGEYITMPLSVEQALLTRDVVAKTLYAQLFDWLVDRINESIayseSTGASR--FIGIVDIFGFEIFATNSLEQLCINF 394
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  485 TNEKLQQFFNHHMFVLEQEEYKKEGIVWEFIDFGMDlAACIELIE-KPLGIFSILEEECMFPKATDTSFKNKLYDQhLGK 563
Cdd:cd14901   395 ANEKLQQLFGKFVFEMEQDEYVAEAIPWTFVEYPNN-DACVAMFEaRPTGLFSLLDEQCLLPRGNDEKLANKYYDL-LAK 472
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  564 CNAFQKPKPAKGKAEahFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATlyppvveetgggkkggkkkg 643
Cdd:cd14901   473 HASFSVSKLQQGKRQ--FVIHHYAGAVCYATDGFCDKNKDHVHSEALALLRTSSNAFLSS-------------------- 530
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  644 gsmqTVSSQFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQR 723
Cdd:cd14901   531 ----TVVAKFKVQLSSLLEVLNATEPHFIRCIKPNDVLSPSEFDAKRVLEQLRCSGVLEAVKISRSGYPVRFPHDAFVHT 606
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*..
gi 288856329  724 YKVLNASVIPEGQFIDNKKASEKLLGSIDV----NHDEYRFGHTKVF 766
Cdd:cd14901   607 YSCLAPDGASDTWKVNELAERLMSQLQHSElnieHLPPFQVGKTKVF 653
MYSc_Myo10 cd14873
class X myosin, motor domain; Myosin X is an unconventional myosin motor that functions as a ...
102-768 4.63e-154

class X myosin, motor domain; Myosin X is an unconventional myosin motor that functions as a monomer. In mammalian cells, the motor is found to localize to filopodia. Myosin X walks towards the barbed ends of filaments and is thought to walk on bundles of actin, rather than single filaments, a unique behavior. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. C-terminal to the head domain are a variable number of IQ domains, 2 PH domains, a MyTH4 domain, and a FERM domain. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276840 [Multi-domain]  Cd Length: 651  Bit Score: 490.08  E-value: 4.63e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  102 SVLYNLKERYAAWMIYTYSGLFCATVNPYKWLP-VYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLITG 180
Cdd:cd14873     2 SIMYNLFQRYKRNQIYTYIGSILASVNPYQPIAgLYEPATMEQYSRRHLGELPPHIFAIANECYRCLWKRHDNQCILISG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  181 ESGAGKTVNTKRVIQYFATVAVQGPEKKkeqaSGKMQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTSG 260
Cdd:cd14873    82 ESGAGKTESTKLILKFLSVISQQSLELS----LKEKTSCVEQAILESSPIMEAFGNAKTVYNNNSSRFGKFVQLNICQKG 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  261 KLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPELIEMtLITTNPYDFPMCSQ-GQITVASIDDKEELVATDTA 339
Cdd:cd14873   158 NIQGGRIVDYLLEKNRVVRQNPGERNYHIFYALLAGLEHEEREE-FYLSTPENYHYLNQsGCVEDKTISDQESFREVITA 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  340 IDILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQREEQAEPDGTEEADKigyLLGLNSADMLKALCYPRVKVGNEFVTKGQ 419
Cdd:cd14873   237 MEVMQFSKEEVREVSRLLAGILHLGNIEFITAGGAQVSFKTALGRSAE---LLGLDPTQLTDALTQRSMFLRGEEILTPL 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  420 TVPQVYNSVSALSKSIYERMFLWMVVRINQMLdtKQQRNF-FIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFNHHMF 498
Cdd:cd14873   314 NVQQAVDSRDSLAMALYARCFEWVIKKINSRI--KGKEDFkSIGILDIFGFENFEVNHFEQFNINYANEKLQEYFNKHIF 391
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  499 VLEQEEYKKEGIVWEFIDFgMDLAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQHlGKCNAFQKPKpakgKAE 578
Cdd:cd14873   392 SLEQLEYSREGLVWEDIDW-IDNGECLDLIEKKLGLLALINEESHFPQATDSTLLEKLHSQH-ANNHFYVKPR----VAV 465
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  579 AHFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYPPVVEETGGGKKGGKKKGGSmQTVSSQFRENLG 658
Cdd:cd14873   466 NNFGVKHYAGEVQYDVRGILEKNRDTFRDDLLNLLRESRFDFIYDLFEHVSSRNNQDTLKCGSKHRR-PTVSSQFKDSLH 544
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  659 KLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVL-NASVIPEgqf 737
Cdd:cd14873   545 SLMATLSSSNPFFVRCIKPNMQKMPDQFDQAVVLNQLRYSGMLETVRIRKAGYAVRRPFQDFYKRYKVLmRNLALPE--- 621
                         650       660       670
                  ....*....|....*....|....*....|.
gi 288856329  738 iDNKKASEKLLGSIDVNHDEYRFGHTKVFFK 768
Cdd:cd14873   622 -DVRGKCTSLLQLYDASNSEWQLGKTKVFLR 651
MYSc_Myo3 cd01379
class III myosin, motor domain; Myosin III has been shown to play a role in the vision process ...
101-768 9.01e-152

class III myosin, motor domain; Myosin III has been shown to play a role in the vision process in insects and in hearing in mammals. Myosin III, an unconventional myosin, does not form dimers. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. They are characterized by an N-terminal protein kinase domain and several IQ domains. Some members also contain WW, SH2, PH, and Y-phosphatase domains. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276830 [Multi-domain]  Cd Length: 633  Bit Score: 482.93  E-value: 9.01e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  101 PSVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLITG 180
Cdd:cd01379     1 DTIVSQLQKRYSRDQIYTYIGDILIAVNPFQNLGIYTEEHSRLYRGAKRSDNPPHIFAVADAAYQAMIHQKKNQCIVISG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  181 ESGAGKTVNTKRVIQYFATVavqgpekkkeqasGKMQ-GSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTS 259
Cdd:cd01379    81 ESGAGKTESANLLVQQLTVL-------------GKANnRTLEEKILQVNPLMEAFGNARTVINDNSSRFGKYLEMKFTST 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  260 GKLASADIETYLLEKSRVTFQLPDERGYHIFYQMMT--NHKPELIEMTLITTNP----YDFPMCSQGQITVASIDDKEEL 333
Cdd:cd01379   148 GAVTGARISEYLLEKSRVVHQAIGERNFHIFYYIYAglAEDKKLAKYKLPENKPprylQNDGLTVQDIVNNSGNREKFEE 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  334 VatDTAIDILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQREEQ----AEPDGTEEADKIGYLLGLNSADMLKALCYPRVK 409
Cdd:cd01379   228 I--EQCFKVIGFTKEEVDSVYSILAAILHIGDIEFTEVESNHQtdksSRISNPEALNNVAKLLGIEADELQEALTSHSVV 305
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  410 VGNEFVTKGQTVPQVYNSVSALSKSIYERMFLWMVVRINQMLdtKQQRNFF-----IGVLDIAGFEIFDFNSMEQLCINF 484
Cdd:cd01379   306 TRGETIIRNNTVEEATDARDAMAKALYGRLFSWIVNRINSLL--KPDRSASdeplsIGILDIFGFENFQKNSFEQLCINI 383
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  485 TNEKLQQFFNHHMFVLEQEEYKKEGIVWEFIDFG-----MDLaacieLIEKPLGIFSILEEECMFPKATDTSFKNKLYDQ 559
Cdd:cd01379   384 ANEQIQYYFNQHIFAWEQQEYLNEGIDVDLIEYEdnrplLDM-----FLQKPMGLLALLDEESRFPKATDQTLVEKFHNN 458
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  560 HlgKCNAFQKPKpakgKAEAHFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLatlyppvveetgggkkgg 639
Cdd:cd01379   459 I--KSKYYWRPK----SNALSFGIHHYAGKVLYDASGFLEKNRDTLPPDVVQLLRSSENPLV------------------ 514
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  640 kkkggsMQTVSSQFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYAD 719
Cdd:cd01379   515 ------RQTVATYFRYSLMDLLSKMVVGQPHFVRCIKPNDSRQAGKFDREKVLKQLRYTGVLETTRIRRQGFSHRILFAD 588
                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|.
gi 288856329  720 FKQRYKVL--NASVIPEGqfidNKKASEKLLgsIDVNHDEYRFGHTKVFFK 768
Cdd:cd01379   589 FLKRYYFLafKWNEEVVA----NRENCRLIL--ERLKLDNWALGKTKVFLK 633
MYSc_Myo9 cd01385
class IX myosin, motor domain; Myosin IX is a processive single-headed motor, which might play ...
102-768 1.48e-151

class IX myosin, motor domain; Myosin IX is a processive single-headed motor, which might play a role in signalling. It has a N-terminal RA domain, an IQ domain, a C1_1 domain, and a RhoGAP domain. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276836 [Multi-domain]  Cd Length: 690  Bit Score: 484.57  E-value: 1.48e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  102 SVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLITGE 181
Cdd:cd01385     2 TLLENLRARFKHGKIYTYVGSILIAVNPFKFLPIYNPKYVKMYQNRRLGKLPPHIFAIADVAYHAMLRKKKNQCIVISGE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  182 SGAGKTVNTKRVIQYFATVAVQGpekkkeQASGkmqgsLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTSGK 261
Cdd:cd01385    82 SGSGKTESTNFLLHHLTALSQKG------YGSG-----VEQTILGAGPVLEAFGNAKTAHNNNSSRFGKFIQVNYRENGM 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  262 LASADIETYLLEKSRVTFQLPDERGYHIFYQMMTN-HKPELIEMTLITTNPYDFPMCSQGqITVASIDDKEELVATDTAI 340
Cdd:cd01385   151 VRGAVVEKYLLEKSRIVSQEKNERNYHVFYYLLAGaSEEERKELHLKQPEDYHYLNQSDC-YTLEGEDEKYEFERLKQAM 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  341 DILGFNNEEKMGIYKFTGAVLHHGNMKFKQK--QREEQAEPDGTEEADKIGYLLGLNSADMLKALCYPRVKVGNEFVTKG 418
Cdd:cd01385   230 EMVGFLPETQRQIFSVLSAVLHLGNIEYKKKayHRDESVTVGNPEVLDIISELLRVKEETLLEALTTKKTVTVGETLILP 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  419 QTVPQVYNSVSALSKSIYERMFLWMVVRINQML----DTKQQRNFFIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFN 494
Cdd:cd01385   310 YKLPEAIATRDAMAKCLYSALFDWIVLRINHALlnkkDLEEAKGLSIGVLDIFGFEDFGNNSFEQFCINYANEHLQYYFN 389
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  495 HHMFVLEQEEYKKEGIVWEFIDFgMDLAACIELIE-KPLGIFSILEEECMFPKATDTSFKNKlYDQHLGKCNAFQKPKpa 573
Cdd:cd01385   390 QHIFKLEQEEYKKEGISWHNIEY-TDNTGCLQLISkKPTGLLCLLDEESNFPGATNQTLLAK-FKQQHKDNKYYEKPQ-- 465
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  574 kgKAEAHFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSS---VKLLATLYPPVV--------------------- 629
Cdd:cd01385   466 --VMEPAFIIAHYAGKVKYQIKDFREKNLDLMRPDIVAVLRSSSsafVRELIGIDPVAVfrwavlrafframaafreagr 543
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  630 ---EETGGGKKGGKKKGGSM----------QTVSSQFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLR 696
Cdd:cd01385   544 rraQRTAGHSLTLHDRTTKSllhlhkkkkpPSVSAQFQTSLSKLMETLGQAEPFFIRCIKSNAEKKPLRFDDELVLRQLR 623
                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 288856329  697 CNGVLEGIRICRKGFPSRILYADFKQRYKVLnasvIPEGQfIDNKKASEKLLGSIDVNHDEYRFGHTKVFFK 768
Cdd:cd01385   624 YTGMLETVRIRRSGYSVRYTFQEFITQFQVL----LPKGL-ISSKEDIKDFLEKLNLDRDNYQIGKTKVFLK 690
MYSc_Myo31 cd14892
class XXXI myosin, motor domain; Class XXXI myosins have a very long neck region consisting of ...
107-768 6.62e-151

class XXXI myosin, motor domain; Class XXXI myosins have a very long neck region consisting of 17 IQ motifs and 2 tandem ANK repeats that are separated by a PH domain. The myosin classes XXX to XXXIV contain members from Phytophthora species and Hyaloperonospora parasitica. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276857 [Multi-domain]  Cd Length: 656  Bit Score: 481.57  E-value: 6.62e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  107 LKERYAAWMIYTYSGLFCATVNPYKWLP-VYDAEVVAAYRGKKRME--APPHIFSVSDNAYQFMLTDR----ENQSVLIT 179
Cdd:cd14892     7 LRRRYERDAIYTFTADILISINPYKSIPlLYDVPGFDSQRKEEATAssPPPHVFSIAERAYRAMKGVGkgqgTPQSIVVS 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  180 GESGAGKTVNTKRVIQYFATVAVQGPEKKKEQASGKMQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTS 259
Cdd:cd14892    87 GESGAGKTEASKYIMKYLATASKLAKGASTSKGAANAHESIEECVLLSNLILEAFGNAKTIRNDNSSRFGKYIQIHYNSD 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  260 GKLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNhKPELIEMTLITTNPYDFPMCSQGQ-ITVASIDDKEELVATDT 338
Cdd:cd14892   167 GRIAGASTDHFLLEKSRLVGPDANERNYHIFYQLLAG-LDANENAALELTPAESFLFLNQGNcVEVDGVDDATEFKQLRD 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  339 AIDILGFNNEEKMGIYKFTGAVLHHGNMKFKQ--KQREEQAEPDGTEEADKIGYLLGLNSADMLKALCYpRVKVGnefvT 416
Cdd:cd14892   246 AMEQLGFDAEFQRPIFEVLAAVLHLGNVRFEEnaDDEDVFAQSADGVNVAKAAGLLGVDAAELMFKLVT-QTTST----A 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  417 KGQ------TVPQVYNSVSALSKSIYERMFLWMVVRINQMldTKQQ------------RNFFIGVLDIAGFEIFDFNSME 478
Cdd:cd14892   321 RGSvleiklTAREAKNALDALCKYLYGELFDWLISRINAC--HKQQtsgvtggaasptFSPFIGILDIFGFEIMPTNSFE 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  479 QLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIVWEFIDFgMDLAACIELIEK-PLGIFSILEEECMFP-KATDTSFKNKL 556
Cdd:cd14892   399 QLCINFTNEMLQQQFNKHVFVLEQEVYASEGIDVSAIEF-QDNQDCLDLIQKkPLGLLPLLEEQMLLKrKTTDKQLLTIY 477
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  557 YDQHLGKCNAFQKPKpakgKAEAHFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKssvkllatlyppvveetgggk 636
Cdd:cd14892   478 HQTHLDKHPHYAKPR----FECDEFVLRHYAGDVTYDVHGFLAKNNDNLHDDLRDLLRS--------------------- 532
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  637 kggkkkggsmqtvSSQFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRIL 716
Cdd:cd14892   533 -------------SSKFRTQLAELMEVLWSTTPSYIKCIKPNNLKFPGGFSCELVRDQLIYSGVLEVVRIRREGFPIRRQ 599
                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 288856329  717 YADFKQRYKVLNASVIPEGQFIDNKKASE--KLLGSIDVNH---DEYRFGHTKVFFK 768
Cdd:cd14892   600 FEEFYEKFWPLARNKAGVAASPDACDATTarKKCEEIVARAlerENFQLGRTKVFLR 656
MYSc_Myo36 cd14897
class XXXVI myosin, motor domain; This class of molluscan myosins contains a motor domain ...
102-768 1.23e-139

class XXXVI myosin, motor domain; This class of molluscan myosins contains a motor domain followed by a GlcAT-I (Beta1,3-glucuronyltransferase I) domain. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276862 [Multi-domain]  Cd Length: 635  Bit Score: 449.53  E-value: 1.23e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  102 SVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKK-RMEAPPHIFSVSDNAYQFMLTDRENQSVLITG 180
Cdd:cd14897     2 TIVQTLKSRYNKDKFYTYIGDILVAVNPCKPLPIFDKKHHEEYSNLSvRSQRPPHLFWIADQAYRRLLETGRNQCILVSG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  181 ESGAGKTVNTKRVIQYFATVavqgpekkkeqaSGKMQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTSG 260
Cdd:cd14897    82 ESGAGKTESTKYMIKHLMKL------------SPSDDSDLLDKIVQINPLLEAFGNASTVMNDNSSRFGKFIELHFTENG 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  261 KLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPELIeMTLITTNPYDFPMCSQGQITVASIDDKEEL----VAT 336
Cdd:cd14897   150 QLLGAKIDDYLLEKSRVVHRGNGEKNFHIFYALFAGMSRDRL-LYYFLEDPDCHRILRDDNRNRPVFNDSEELeyyrQMF 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  337 DTAIDIL---GFNNEEKMGIYKFTGAVLHHGNMKFkqkqrEEQAEPDGTEEADK-----IGYLLGLNSADMLKALCYPRV 408
Cdd:cd14897   229 HDLTNIMkliGFSEEDISVIFTILAAILHLTNIVF-----IPDEDTDGVTVADEyplhaVAKLLGIDEVELTEALISNVN 303
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  409 KVGNEFVTKGQTVPQVYNSVSALSKSIYERMFLWMVVRINQMLDTKQQ-----RNFFIGVLDIAGFEIFDFNSMEQLCIN 483
Cdd:cd14897   304 TIRGERIQSWKSLRQANDSRDALAKDLYSRLFGWIVGQINRNLWPDKDfqimtRGPSIGILDMSGFENFKINSFDQLCIN 383
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  484 FTNEKLQQFFNHHMFVLEQEEYKKEGIVWEFIDFgMDLAACIELI-EKPLGIFSILEEECMFPKATDTSFKNKLYDqhlg 562
Cdd:cd14897   384 LSNERLQQYFNDYVFPRERSEYEIEGIEWRDIEY-HDNDDVLELFfKKPLGILPLLDEESTFPQSTDSSLVQKLNK---- 458
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  563 KCNAFQKPKPAKGKaEAHFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYppvveetgggkkggkkk 642
Cdd:cd14897   459 YCGESPRYVASPGN-RVAFGIRHYAEQVTYDADGFLEKNRDNLSSDIVGCLLNSNNEFISDLF----------------- 520
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  643 ggsmqtvSSQFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQ 722
Cdd:cd14897   521 -------TSYFKRSLSDLMTKLNSADPLFVRCIKPNNFLRPNKFDDELVRRQLLCNGLMEIAKIRRDGYPIRIKYEDFVK 593
                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|.
gi 288856329  723 RYKVL-----NASVIPEGQFIDNKKasekllgsiDVNHDEYRFGHTKVFFK 768
Cdd:cd14897   594 RYKEIcdfsnKVRSDDLGKCQKILK---------TAGIKGYQFGKTKVFLK 635
MYSc_Myo43 cd14904
class XLIII myosin, motor domain; The class XLIII myosins are comprised of Stramenopiles. Not ...
101-768 1.71e-139

class XLIII myosin, motor domain; The class XLIII myosins are comprised of Stramenopiles. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276869  Cd Length: 653  Bit Score: 449.78  E-value: 1.71e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  101 PSVLYNLKERYAAWMIYTYSGLFCATVNPYKWLP-VYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLIT 179
Cdd:cd14904     1 PSILFNLKKRFAASKPYTYTNDIVIALNPYKWIDnLYGDHLHEQYLKKPRDKLQPHVYATSTAAYKHMLTNEMNQSILVS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  180 GESGAGKTVNTKRVIQYFATVAvqgpekkkeqasGKMQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTS 259
Cdd:cd14904    81 GESGAGKTETTKIVMNHLASVA------------GGRKDKTIAKVIDVNPLLESFGNAKTTRNDNSSRFGKFTQLQFDGR 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  260 GKLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTN-HKPELIEMTLITTNPYDFPMCSQGQITVASIDDKEELVATDT 338
Cdd:cd14904   149 GKLIGAKCETYLLEKSRVVSIAEGERNYHIFYQLLAGlSSEERKEFGLDPNCQYQYLGDSLAQMQIPGLDDAKLFASTQK 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  339 AIDILGFNNEEKMGIYKFTGAVLHHGNMKFkQKQREEQAEPDGTEEADKIGYLLGLNSADMLKALCYPRVKVGNEFVTKG 418
Cdd:cd14904   229 SLSLIGLDNDAQRTLFKILSGVLHLGEVMF-DKSDENGSRISNGSQLSQVAKMLGLPTTRIEEALCNRSVVTRNESVTVP 307
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  419 QTVPQVYNSVSALSKSIYERMFLWMVVRINQMLDTKQQRNF-FIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFNHHM 497
Cdd:cd14904   308 LAPVEAEENRDALAKAIYSKLFDWMVVKINAAISTDDDRIKgQIGVLDIFGFEDFAHNGFEQFCINYANEKLQQKFTTDV 387
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  498 FVLEQEEYKKEGIVWEFIDFgMDLAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQH--LGKCNAFQKPKPAKg 575
Cdd:cd14904   388 FKTVEEEYIREGLQWDHIEY-QDNQGIVEVIDGKMGIIALMNDHLRQPRGTEEALVNKIRTNHqtKKDNESIDFPKVKR- 465
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  576 kaeAHFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYPPVVEETGGGKKGGKKKGGSMQTVSSQFRE 655
Cdd:cd14904   466 ---TQFIINHYAGPVTYETVGFMEKHRDTLQNDLLDLVLLSSLDLLTELFGSSEAPSETKEGKSGKGTKAPKSLGSQFKT 542
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  656 NLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLnasVIPEG 735
Cdd:cd14904   543 SLSQLMDNIKTTNTHYVRCIKPNANKSPTEFDKRMVVEQLRSAGVIEAIRITRSGYPSRLTPKELATRYAIM---FPPSM 619
                         650       660       670
                  ....*....|....*....|....*....|....
gi 288856329  736 QFIDNKKASEKLLGSIDVNHD-EYRFGHTKVFFK 768
Cdd:cd14904   620 HSKDVRRTCSVFMTAIGRKSPlEYQIGKSLIYFK 653
MYSc_Myo39 cd14900
class XXXIX myosin, motor domain; The class XXXIX myosins are found in Stramenopiles. Not much ...
102-727 2.09e-139

class XXXIX myosin, motor domain; The class XXXIX myosins are found in Stramenopiles. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276865  Cd Length: 627  Bit Score: 448.60  E-value: 2.09e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  102 SVLYNLKERYAAWMIYTYSGLFCATVNPYKWLP-VYDAEVVAAY-----------RGKKRMEAPPHIFSVSDNAYQFM-- 167
Cdd:cd14900     2 TILSALETRFYAQKIYTNTGAILLAVNPFQKLPgLYSSDTMAKYllsfearssstRNKGSDPMPPHIYQVAGEAYKAMml 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  168 --LTDRENQSVLITGESGAGKTVNTKRVIQYFATVAvqGPEKKKEQASGKMQGSLEDQIIAANPLLEAYGNAKTVRNDNS 245
Cdd:cd14900    82 glNGVMSDQSILVSGESGSGKTESTKFLMEYLAQAG--DNNLAASVSMGKSTSGIAAKVLQTNILLESFGNARTLRNDNS 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  246 SRFGKFIRIHFGTSGKLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPELIEMTLITtnpydfpmcsqgQITva 325
Cdd:cd14900   160 SRFGKFIKLHFTSGGRLTGASIQTYLLEKVRLVSQSKGERNYHIFYEMAIGASEAARKRDMYR------------RVM-- 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  326 siddkeelvatdTAIDILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQREEQAEPDGTEEA-------DKIGYLLGLNSAD 398
Cdd:cd14900   226 ------------DAMDIIGFTPHERAGIFDLLAALLHIGNLTFEHDENSDRLGQLKSDLApssiwsrDAAATLLSVDATK 293
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  399 MLKALCYPRVKVGNEFVTKGQTVPQVYNSVSALSKSIYERMFLWMVVRINQML-----DTKQQRNFFIGVLDIAGFEIFD 473
Cdd:cd14900   294 LEKALSVRRIRAGTDFVSMKLSAAQANNARDALAKALYGRLFDWLVGKMNAFLkmddsSKSHGGLHFIGILDIFGFEVFP 373
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  474 FNSMEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIVWEFIDFgMDLAACIELI-EKPLGIFSILEEECMFPKATDTSF 552
Cdd:cd14900   374 KNSFEQLCINFANETLQQQFNDYVFKAEQREYESQGVDWKYVEF-CDNQDCVNLIsQRPTGILSLIDEECVMPKGSDTTL 452
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  553 KNKLYdQHLGKCNAFQKPKPAKGKaeAHFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKssvkllatlyppvveet 632
Cdd:cd14900   453 ASKLY-RACGSHPRFSASRIQRAR--GLFTIVHYAGHVEYSTDGFLEKNKDVLHQEAVDLFVY----------------- 512
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  633 gggkkggkkkggsmqtvSSQFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFP 712
Cdd:cd14900   513 -----------------GLQFKEQLTTLLETLQQTNPHYVRCLKPNDLCKAGIYERERVLNQLRCNGVMEAVRVARAGFP 575
                         650
                  ....*....|....*
gi 288856329  713 SRILYADFKQRYKVL 727
Cdd:cd14900   576 IRLLHDEFVARYFSL 590
MYSc_Myo46 cd14907
class XLVI myosin, motor domain; The class XLVI myosins are comprised of Alveolata. Not much ...
101-768 4.12e-137

class XLVI myosin, motor domain; The class XLVI myosins are comprised of Alveolata. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276872 [Multi-domain]  Cd Length: 669  Bit Score: 443.70  E-value: 4.12e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  101 PSVLYNLKERYAAWMIYTYSGLFCATVNPYKWLP-VYDAEVVAAYRGK--------KRMEAPPHIFSVSDNAYQFMLTDR 171
Cdd:cd14907     1 AELLINLKKRYQQDKIFTYVGPTLIVMNPYKQIDnLFSEEVMQMYKEQiiqngeyfDIKKEPPHIYAIAALAFKQLFENN 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  172 ENQSVLITGESGAGKTVNTKRVIQYFATVAVQGPE-------KKKEQASGKMQGSLEDQIIAANPLLEAYGNAKTVRNDN 244
Cdd:cd14907    81 KKQAIVISGESGAGKTENAKYAMKFLTQLSQQEQNseevltlTSSIRATSKSTKSIEQKILSCNPILEAFGNAKTVRNDN 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  245 SSRFGKFIRIHFG-TSGKLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPELIE-MTLITTNPYDFPMC-SQGQ 321
Cdd:cd14907   161 SSRFGKYVSILVDkKKRKILGARIQNYLLEKSRVTQQGQGERNYHIFYHLLYGADQQLLQqLGLKNQLSGDRYDYlKKSN 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  322 -ITVASIDDKEELVATDTAIDILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQ--REEQAEPDGTEEADKIGYLLGLNSAD 398
Cdd:cd14907   241 cYEVDTINDEKLFKEVQQSFQTLGFTEEEQDSIWRILAAILLLGNLQFDDSTldDNSPCCVKNKETLQIIAKLLGIDEEE 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  399 MLKALCYPRVKVGNEFVTKGQTVPQVYNSVSALSKSIYERMFLWMVVRINQML--------DTKQQRNFFIGVLDIAGFE 470
Cdd:cd14907   321 LKEALTTKIRKVGNQVITSPLSKKECINNRDSLSKELYDRLFNWLVERLNDTImpkdekdqQLFQNKYLSIGLLDIFGFE 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  471 IFDFNSMEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIVWEF--IDFgMDLAACIELIEK-PLGIFSILEEECMFPKA 547
Cdd:cd14907   401 VFQNNSFEQLCINYTNEKLQQLYISYVFKAEEQEFKEEGLEDYLnqLSY-TDNQDVIDLLDKpPIGIFNLLDDSCKLATG 479
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  548 TDTSFKNKLYDQHlgkcNAFQKPKPAKGKAEAHFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYPP 627
Cdd:cd14907   480 TDEKLLNKIKKQH----KNNSKLIFPNKINKDTFTIRHTAKEVEYNIEGFREKNKDEISQSIINCIQNSKNRIISSIFSG 555
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  628 VVEETGGGKKGGKKKGGSMQTVSSQFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRIC 707
Cdd:cd14907   556 EDGSQQQNQSKQKKSQKKDKFLGSKFRNQMKQLMNELMQCDVHFIRCIKPNEEKKADLFIQGYVLNQIRYLGVLESIRVR 635
                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 288856329  708 RKGFPSRILYADFKQRYKVLNASVIpegqfidnkkasekllgsidvnhdeyrFGHTKVFFK 768
Cdd:cd14907   636 KQGYPYRKSYEDFYKQYSLLKKNVL---------------------------FGKTKIFMK 669
MYSc_Myo28 cd14889
class XXVIII myosin, motor domain; These myosins are found in fish, chicken, and mollusks. The ...
103-768 3.97e-135

class XXVIII myosin, motor domain; These myosins are found in fish, chicken, and mollusks. The tail regions of these class-XXVIII myosins consist of an IQ motif, a short coiled-coil region, and an SH2 domain. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276854  Cd Length: 659  Bit Score: 437.80  E-value: 3.97e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  103 VLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFML----TDRENQSVLI 178
Cdd:cd14889     3 LLEVLKVRFMQSNIYTYVGDILVAINPFKYLHIYEKEVSQKYKCEKKSSLPPHIFAVADRAYQSMLgrlaRGPKNQCIVI 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  179 TGESGAGKTVNTKRVIQYFAtvavqgpekkkEQASGKMQgsLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFgT 258
Cdd:cd14889    83 SGESGAGKTESTKLLLRQIM-----------ELCRGNSQ--LEQQILQVNPLLEAFGNAQTVMNDNSSRFGKYIQLRF-R 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  259 SGKLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPELIEM-TLITTNPYDFPMCSQGQITVASIDDKE--ELVa 335
Cdd:cd14889   149 NGHVKGAKINEYLLEKSRVVHQDGGEENFHIFYYMFAGISAEDRENyGLLDPGKYRYLNNGAGCKREVQYWKKKydEVC- 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  336 tdTAIDILGFNNEEKMGIYKFTGAVLHHGNMKFkqkqreeqaEPDGTE----EADKIGYL------LGLNSADMLKALCY 405
Cdd:cd14889   228 --NAMDMVGFTEQEEVDMFTILAGILSLGNITF---------EMDDDEalkvENDSNGWLkaaagqFGVSEEDLLKTLTC 296
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  406 PRVKVGNEFVTKGQTVPQVYNSVSALSKSIYERMFLWMVVRINQMLDTKQQRNF---FIGVLDIAGFEIFDFNSMEQLCI 482
Cdd:cd14889   297 TVTFTRGEQIQRHHTKQQAEDARDSIAKVAYGRVFGWIVSKINQLLAPKDDSSVelrEIGILDIFGFENFAVNRFEQACI 376
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  483 NFTNEKLQQFFNHHMFVLEQEEYKKEGIVWEFIDFgMDLAACIEL-IEKPLGIFSILEEECMFPKATDTSFKNKLyDQHL 561
Cdd:cd14889   377 NLANEQLQYFFNHHIFLMEQKEYKKEGIDWKEITY-KDNKPILDLfLNKPIGILSLLDEQSHFPQATDESFVDKL-NIHF 454
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  562 GKCNAFQKPKPAKGKaeahFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYPPVVEETGGGKKGGKK 641
Cdd:cd14889   455 KGNSYYGKSRSKSPK----FTVNHYAGKVTYNASGFLEKNRDTIPASIRTLFINSATPLLSVLFTATRSRTGTLMPRAKL 530
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  642 KGGS--------MQTVSSQFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPS 713
Cdd:cd14889   531 PQAGsdnfnstrKQSVGAQFKHSLGVLMEKMFAASPHFVRCIKPNHVKVPGQLDSKYIQDQLRYNGLLETIRIRREGFSW 610
                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 288856329  714 RILYADFKQRYKVLnasvIPEGQFIDNKKASEKLLGSIDVNhdEYRFGHTKVFFK 768
Cdd:cd14889   611 RPSFAEFAERYKIL----LCEPALPGTKQSCLRILKATKLV--GWKCGKTRLFFK 659
PTZ00014 PTZ00014
myosin-A; Provisional
56-827 6.92e-132

myosin-A; Provisional


Pssm-ID: 240229 [Multi-domain]  Cd Length: 821  Bit Score: 434.46  E-value: 6.92e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   56 DGGKVTVITLD--TKEEKVVKEDDV----HPMNPPKFDkieDMAMMTHLNEPSVLYNLKERYAAWMIYTYSGLFCATVNP 129
Cdd:PTZ00014   62 TGEKLTLKQIDppTNSTFEVKPEHAfnanSQIDPMTYG---DIGLLPHTNIPCVLDFLKHRYLKNQIYTTADPLLVAINP 138
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  130 YKWLPVYDAEVVAAYR-GKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLITGESGAGKTVNTKRVIQYFATvavqgpekk 208
Cdd:PTZ00014  139 FKDLGNTTNDWIRRYRdAKDSDKLPPHVFTTARRALENLHGVKKSQTIIVSGESGAGKTEATKQIMRYFAS--------- 209
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  209 keQASGKMQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTSGKLASADIETYLLEKSRVTFQLPDERGYH 288
Cdd:PTZ00014  210 --SKSGNMDLKIQNAIMAANPVLEAFGNAKTIRNNNSSRFGRFMQLQLGEEGGIRYGSIVAFLLEKSRVVTQEDDERSYH 287
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  289 IFYQMMTNHKPELIE-MTLITTNPYDF--PMCsqgqITVASIDDKEELVATDTAIDILGFNNEEKMGIYKFTGAVLHHGN 365
Cdd:PTZ00014  288 IFYQLLKGANDEMKEkYKLKSLEEYKYinPKC----LDVPGIDDVKDFEEVMESFDSMGLSESQIEDIFSILSGVLLLGN 363
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  366 MKFKQKQREEQAE-----PDGTEEADKIGYLLGLNSADMLKALCYPRVKVGNEFVTKGQTVPQVYNSVSALSKSIYERMF 440
Cdd:PTZ00014  364 VEIEGKEEGGLTDaaaisDESLEVFNEACELLFLDYESLKKELTVKVTYAGNQKIEGPWSKDESEMLKDSLSKAVYEKLF 443
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  441 LWMVVRINQMLDTKQQRNFFIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIVWEFIDFGMD 520
Cdd:PTZ00014  444 LWIIRNLNATIEPPGGFKVFIGMLDIFGFEVFKNNSLEQLFINITNEMLQKNFVDIVFERESKLYKDEGISTEELEYTSN 523
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  521 LAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQhLGKCNAFqkpKPAKGKAEAHFSLVHYAGTVDYNISGWLDK 600
Cdd:PTZ00014  524 ESVIDLLCGKGKSVLSILEDQCLAPGGTDEKFVSSCNTN-LKNNPKY---KPAKVDSNKNFVIKHTIGDIQYCASGFLFK 599
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  601 NKDPLNESVVQLYQKSSVKLLATLYPPVVEETGGGKKGgkkkggsmQTVSSQFRENLGKLMTNLRSTHPHFVRCLIPNES 680
Cdd:PTZ00014  600 NKDVLRPELVEVVKASPNPLVRDLFEGVEVEKGKLAKG--------QLIGSQFLNQLDSLMSLINSTEPHFIRCIKPNEN 671
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  681 KTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASVIpEGQFIDNKKASEKLLGSIDVNHDEYRF 760
Cdd:PTZ00014  672 KKPLDWNSSKVLIQLHSLSILEALQLRQLGFSYRRTFAEFLSQFKYLDLAVS-NDSSLDPKEKAEKLLERSGLPKDSYAI 750
                         730       740       750       760       770       780       790
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  761 GHTKVFFKAGLLGTLEEMRDEKLAS---LVTMTQALCRAYLMRRefvKMMERRDAIYTIQYNVRSFMNVK 827
Cdd:PTZ00014  751 GKTMVFLKKDAAKELTQIQREKLAAwepLVSVLEALILKIKKKR---KVRKNIKSLVRIQAHLRRHLVIA 817
MYSc_Myo47 cd14908
class XLVII myosin, motor domain; The class XLVII myosins are comprised of Stramenopiles. Not ...
101-734 1.17e-127

class XLVII myosin, motor domain; The class XLVII myosins are comprised of Stramenopiles. Not much is known about this myosin class. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276873 [Multi-domain]  Cd Length: 682  Bit Score: 417.77  E-value: 1.17e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  101 PSVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRG-----KKRMEAP----PHIFSVSDNAYQFMLTD- 170
Cdd:cd14908     1 PAILHSLSRRFFRGIIYTWTGPVLIAVNPFQRLPLYGKEILESYRQegllrSQGIESPqalgPHVFAIADRSYRQMMSEi 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  171 RENQSVLITGESGAGKTVNTKRVIQYFATVAVQGPEKKKEQASGKmQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGK 250
Cdd:cd14908    81 RASQSILISGESGAGKTESTKIVMLYLTTLGNGEEGAPNEGEELG-KLSIMDRVLQSNPILEAFGNARTLRNDNSSRFGK 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  251 FIRIHFGTSGKLASADIETYLLEKSRVTFQLPDERGYHIFYQMM------TNHKPELIE-MTLITTNPYDFPMCSQGQI- 322
Cdd:cd14908   160 FIELGFNRAGNLLGAKVQTYLLEKVRLPFHASGERNYHIFYQLLrggdeeEHEKYEFHDgITGGLQLPNEFHYTGQGGAp 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  323 TVASIDDKEELVATDTAIDILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQREEQAEPDGTEEADKIGY---LLGLNSADM 399
Cdd:cd14908   240 DLREFTDEDGLVYTLKAMRTMGWEESSIDTILDIIAGLLHLGQLEFESKEEDGAAEIAEEGNEKCLARvakLLGVDVDKL 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  400 LKALCYPRVKVGNEFVTKGQTVPQVYNSVSALSKSIYERMFLWMVVRINQML--DTKQQRNFFIGVLDIAGFEIFDFNSM 477
Cdd:cd14908   320 LRALTSKIIVVRGKEITTKLTPHKAYDARDALAKTIYGALFLWVVATVNSSInwENDKDIRSSVGVLDIFGFECFAHNSF 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  478 EQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIVWEFIDFGmDLAACIELIE-KPLGIFSILEEECMFP-KATDTSFKNK 555
Cdd:cd14908   400 EQLCINFTNEALQQQFNQFIFKLEQKEYEKESIEWAFIEFP-DNQDCLDTIQaKKKGILTMLDDECRLGiRGSDANYASR 478
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  556 LYDQHLGKCN-----AFQKPKPAKGKAEAHFSLVHYAGTVDYNI-SGWLDKNKDPLnesvvqlyQKSSVKLLATlyppvv 629
Cdd:cd14908   479 LYETYLPEKNqthseNTRFEATSIQKTKLIFAVRHFAGQVQYTVeTTFCEKNKDEI--------PLTADSLFES------ 544
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  630 eetgggkkggkkkggsmqtvSSQFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRK 709
Cdd:cd14908   545 --------------------GQQFKAQLHSLIEMIEDTDPHYIRCIKPNDAAKPDLVTRKRVTEQLRYGGVLEAVRVARS 604
                         650       660
                  ....*....|....*....|....*
gi 288856329  710 GFPSRILYADFKQRYKVLnASVIPE 734
Cdd:cd14908   605 GYPVRLPHKDFFKRYRML-LPLIPE 628
MYSc_Myo30 cd14891
class XXX myosin, motor domain; Myosins of class XXX are composed of an amino-terminal ...
103-768 3.23e-127

class XXX myosin, motor domain; Myosins of class XXX are composed of an amino-terminal SH3-like domain, two IQ motifs, a coiled-coil region and a PX domain. The myosin classes XXX to XXXIV contain members from Phytophthora species and Hyaloperonospora parasitica. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276856  Cd Length: 645  Bit Score: 414.83  E-value: 3.23e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  103 VLYNLKERYAA--WMIYTYSGLFCATVNPYKWLPVYDaevVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRE---NQSVL 177
Cdd:cd14891     3 ILHNLEERSKLdnQRPYTFMANVLIAVNPLRRLPEPD---KSDYINTPLDPCPPHPYAIAEMAYQQMCLGSGrmqNQSIV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  178 ITGESGAGKTVNTKRVIQYFATVAVQGPEKKKEQASGKMQG------SLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKF 251
Cdd:cd14891    80 ISGESGAGKTETSKIILRFLTTRAVGGKKASGQDIEQSSKKrklsvtSLDERLMDTNPILESFGNAKTLRNHNSSRFGKF 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  252 IRIHFGTSG-KLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPELIEmTLITTNPYDFPMCSQ-GQITVASIDD 329
Cdd:cd14891   160 MKLQFTKDKfKLAGAFIETYLLEKSRLVAQPPGERNFHIFYQLLAGASAELLK-ELLLLSPEDFIYLNQsGCVSDDNIDD 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  330 KEELVATDTAIDILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQREE----QAEPDGTEEADKIGYLLGLNSADMLKALCY 405
Cdd:cd14891   239 AANFDNVVSALDTVGIDEDLQLQIWRILAGLLHLGNIEFDEEDTSEgeaeIASESDKEALATAAELLGVDEEALEKVITQ 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  406 PRVKVGNEFVTKGQTVPQVYNSVSALSKSIYERMFLWMVVRINQMLDTKQQRNFFIGVLDIAGFEIFD-FNSMEQLCINF 484
Cdd:cd14891   319 REIVTRGETFTIKRNAREAVYSRDAIAKSIYERLFLWIVQQINTSLGHDPDPLPYIGVLDIFGFESFEtKNDFEQLLINY 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  485 TNEKLQQFFNHHMFVLEQEEYKKEGI-----VWEfidfgmDLAACIELI-EKPLGIFSILEEECMFPKATDTSFKNKLYD 558
Cdd:cd14891   399 ANEALQATFNQQVFIAEQELYKSEGIdvgviTWP------DNRECLDLIaSKPNGILPLLDNEARNPNPSDAKLNETLHK 472
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  559 QHlGKCNAFQKPKPaKGKAEAhFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYqKSSVKLLAtlyppvveetgggkkg 638
Cdd:cd14891   473 TH-KRHPCFPRPHP-KDMREM-FIVKHYAGTVSYTIGSFIDKNNDIIPEDFEDLL-ASSAKFSD---------------- 532
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  639 gkkkggSMQTvssqfrenlgkLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYA 718
Cdd:cd14891   533 ------QMQE-----------LVDTLEATRCNFIRCIKPNAAMKVGVFDNRYVVDQLRCSGILQTCEVLKVGLPTRVTYA 595
                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|..
gi 288856329  719 DFKQRYK-VLNASVIPegQFIDNKKA-SEKLLGSIDVNHDEYRFGHTKVFFK 768
Cdd:cd14891   596 ELVDVYKpVLPPSVTR--LFAENDRTlTQAILWAFRVPSDAYRLGRTRVFFR 645
MYSc_Myo41 cd14902
class XLI myosin, motor domain; The class XLI myosins are comprised of Stramenopiles. Not much ...
101-725 6.06e-127

class XLI myosin, motor domain; The class XLI myosins are comprised of Stramenopiles. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276867 [Multi-domain]  Cd Length: 716  Bit Score: 416.99  E-value: 6.06e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  101 PSVLYNLKERYAAWMIYTYSGLFCATVNPYKWLP-VYDAEVVAAYR--------GKKRMEAPPHIFSVSDNAYQFML-TD 170
Cdd:cd14902     1 AALLQALSERFEHDQIYTSIGDILVALNPLKPLPdLYSESQLNAYKasmtstspVSQLSELPPHVFAIGGKAFGGLLkPE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  171 RENQSVLITGESGAGKTVNTKRVIQYFATVAvqgpekkKEQASGKMQGS----LEDQIIAANPLLEAYGNAKTVRNDNSS 246
Cdd:cd14902    81 RRNQSILVSGESGSGKTESTKFLMQFLTSVG-------RDQSSTEQEGSdaveIGKRILQTNPILESFGNAQTIRNDNSS 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  247 RFGKFIRIHFGTSGKLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPELIEmTLITTNPYDFPM-----CSQGQ 321
Cdd:cd14902   154 RFGKFIKIQFGANNEIVGAQIVSYLLEKVRLLHQSPEERSFHIFYELLEGADKTLLD-LLGLQKGGKYELlnsygPSFAR 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  322 ITVASIDDKEELVATDTAIDILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQREEQAEPDGTEEA---DKIGYLLGLNSAD 398
Cdd:cd14902   233 KRAVADKYAQLYVETVRAFEDTGVGELERLDIFKILAALLHLGNVNFTAENGQEDATAVTAASRfhlAKCAELMGVDVDK 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  399 MLKALCYPRVKVGNEFVTKGQTVPQVYNSVSALSKSIYERMFLWMVVRINQMLD-------TKQQRNFF--IGVLDIAGF 469
Cdd:cd14902   313 LETLLSSREIKAGVEVMVLKLTPEQAKEICGSLAKAIYGRLFTWLVRRLSDEINyfdsavsISDEDEELatIGILDIFGF 392
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  470 EIFDFNSMEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIVWEFIDFGmDLAACIELIE-KPLGIFSILEEECMFPKAT 548
Cdd:cd14902   393 ESLNRNGFEQLCINYANERLQAQFNEFVFVKEQQIYIAEGIDWKNISYP-SNAACLALFDdKSNGLFSLLDQECLMPKGS 471
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  549 DTSFKNKLYDQHLGkcnafqkpkpakgkaEAHFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLL-ATLYPP 627
Cdd:cd14902   472 NQALSTKFYRYHGG---------------LGQFVVHHFAGRVCYNVEQFVEKNTDALPADASDILSSSSNEVVvAIGADE 536
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  628 VVEETGGGKKGGKKKGGSM---QTVSSQFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGI 704
Cdd:cd14902   537 NRDSPGADNGAAGRRRYSMlraPSVSAQFKSQLDRLIVQIGRTEAHYVRCLKPNEVKKPGIFDRERMVEQMRSVGVLEAV 616
                         650       660
                  ....*....|....*....|.
gi 288856329  705 RICRKGFPSRILYADFKQRYK 725
Cdd:cd14902   617 RIARHGYSVRLAHASFIELFS 637
MYSc_Myo34 cd14895
class XXXIV myosin, motor domain; Class XXXIV myosins are composed of an IQ motif, a short ...
101-768 5.45e-123

class XXXIV myosin, motor domain; Class XXXIV myosins are composed of an IQ motif, a short coiled-coil region, 5 tandem ANK repeats, and a carboxy-terminal FYVE domain. The myosin classes XXX to XXXIV contain members from Phytophthora species and Hyaloperonospora parasitica. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276860 [Multi-domain]  Cd Length: 704  Bit Score: 405.11  E-value: 5.45e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  101 PSVLYNLKERYAAWMIYTYSGLFCATVNPYKWLP-VYDaevVAAYRGK--KRMEAPPHIFSVSDNAYQFMLT-------D 170
Cdd:cd14895     1 PAFVDYLAQRYGVDQVYCRSGAVLIAVNPFKHIPgLYD---LHKYREEmpGWTALPPHVFSIAEGAYRSLRRrlhepgaS 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  171 RENQSVLITGESGAGKTVNTKRVIQYFATVAVqgpEKKKEQASGKMQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGK 250
Cdd:cd14895    78 KKNQTILVSGESGAGKTETTKFIMNYLAESSK---HTTATSSSKRRRAISGSELLSANPILESFGNARTLRNDNSSRFGK 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  251 FIRIHFG-----TSGKLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPE-LIEMTLITTNPYDFPMCSQGQITV 324
Cdd:cd14895   155 FVRMFFEgheldTSLRMIGTSVETYLLEKVRVVHQNDGERNFHVFYELLAGAADDmKLELQLELLSAQEFQYISGGQCYQ 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  325 AS--IDDKEELVATDTAIDILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQREEQAEPDGT------------------EE 384
Cdd:cd14895   235 RNdgVRDDKQFQLVLQSMKVLGFTDVEQAAIWKILSALLHLGNVLFVASSEDEGEEDNGAasapcrlasaspssltvqQH 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  385 ADKIGYLLGLNSADMLKALCYPRVKVGNEFVTKGQTVPQVYNSVSALSKSIYERMFLWMVVRINQMLDTKQQRNF----- 459
Cdd:cd14895   315 LDIVSKLFAVDQDELVSALTTRKISVGGETFHANLSLAQCGDARDAMARSLYAFLFQFLVSKVNSASPQRQFALNpnkaa 394
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  460 ------FIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIVWEFIDFGmDLAACIELIE-KPL 532
Cdd:cd14895   395 nkdttpCIAVLDIFGFEEFEVNQFEQFCINYANEKLQYQFIQDILLTEQQAHIEEGIKWNAVDYE-DNSVCLEMLEqRPS 473
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  533 GIFSILEEECMFPKATDTSFKNKLYdQHLGKCNAFQKPKpaKGKAEAHFSLVHYAGTVDYNISGWLDKNKDPLNESVVQL 612
Cdd:cd14895   474 GIFSLLDEECVVPKGSDAGFARKLY-QRLQEHSNFSASR--TDQADVAFQIHHYAGAVRYQAEGFCEKNKDQPNAELFSV 550
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  613 YQKSSVKLLATLYPP--VVEETGGGKKGGKKKGGSMQTVS----SQFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLM 686
Cdd:cd14895   551 LGKTSDAHLRELFEFfkASESAELSLGQPKLRRRSSVLSSvgigSQFKQQLASLLDVVQQTQTHYIRCIKPNDESASDQF 630
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  687 ENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASvipegQFIDNKKASEkLLGSIDVNHDEyrFGHTKVF 766
Cdd:cd14895   631 DMAKVSSQLRYGGVLKAVEIMRQSYPVRMKHADFVKQYRLLVAA-----KNASDATASA-LIETLKVDHAE--LGKTRVF 702

                  ..
gi 288856329  767 FK 768
Cdd:cd14895   703 LR 704
MYSc_Myo14 cd14876
class XIV myosin, motor domain; These myosins localize to plasma membranes of the ...
101-768 1.13e-119

class XIV myosin, motor domain; These myosins localize to plasma membranes of the intracellular parasites and may be involved in the cell invasion process. Their known functions include: transporting phagosomes to the nucleus and perturbing the developmentally regulated elimination of the macronucleus during conjugation. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. C-terminal to their motor domain these myosins have a MyTH4-FERM protein domain combination. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276843  Cd Length: 649  Bit Score: 393.58  E-value: 1.13e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  101 PSVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRG-KKRMEAPPHIFSVSDNAYQFMLTDRENQSVLIT 179
Cdd:cd14876     1 PCVLDFLKHRYLKNQIYTTADPLLVAINPFKDLGNATDEWIRKYRDaPDLTKLPPHVFYTARRALENLHGVNKSQTIIVS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  180 GESGAGKTVNTKRVIQYFATvavqgpekkkeQASGKMQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTS 259
Cdd:cd14876    81 GESGAGKTEATKQIMRYFAS-----------AKSGNMDLRIQTAIMAANPVLEAFGNAKTIRNNNSSRFGRFMQLDVASE 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  260 GKLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPELIE-MTLITTNPYDF--PMCsqgqITVASIDDKEELVAT 336
Cdd:cd14876   150 GGIRYGSVVAFLLEKSRIVTQDDNERSYHIFYQLLKGADSEMKSkYHLLGLKEYKFlnPKC----LDVPGIDDVADFEEV 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  337 DTAIDILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQREEQ-----AEPDGTEEADKIGYLLGLNSADMLKALCYPRVKVG 411
Cdd:cd14876   226 LESLKSMGLTEEQIDTVFSIVSGVLLLGNVKITGKTEQGVddaaaISNESLEVFKEACSLLFLDPEALKRELTVKVTKAG 305
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  412 NEFVTKGQTVPQVYNSVSALSKSIYERMFLWMVVRINQMLDTKQQRNFFIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQ 491
Cdd:cd14876   306 GQEIEGRWTKDDAEMLKLSLAKAMYDKLFLWIIRNLNSTIEPPGGFKNFMGMLDIFGFEVFKNNSLEQLFINITNEMLQK 385
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  492 FFNHHMFVLEQEEYKKEGIVWEFIDFgMDLAACIE-LIEKPLGIFSILEEECMFPKATDTSFKNKLYDQHLGKcnafQKP 570
Cdd:cd14876   386 NFIDIVFERESKLYKDEGIPTAELEY-TSNAEVIDvLCGKGKSVLSILEDQCLAPGGSDEKFVSACVSKLKSN----GKF 460
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  571 KPAKGKAEAHFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYPPVVEETGGGKKGgkkkggsmQTVS 650
Cdd:cd14876   461 KPAKVDSNINFIVVHTIGDIQYNAEGFLFKNKDVLRAELVEVVQASTNPVVKALFEGVVVEKGKIAKG--------SLIG 532
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  651 SQFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNAS 730
Cdd:cd14876   533 SQFLKQLESLMGLINSTEPHFIRCIKPNETKKPLEWNSSKVLIQLHALSILEALQLRQLGYSYRRPFEEFLYQFKFLDLG 612
                         650       660       670
                  ....*....|....*....|....*....|....*...
gi 288856329  731 vIPEGQFIDNKKASEKLLGSIDVNHDEYRFGHTKVFFK 768
Cdd:cd14876   613 -IANDKSLDPKVAALKLLESSGLSEDEYAIGKTMVFLK 649
MYSc_Myo35 cd14896
class XXXV myosin, motor domain; This class of metazoan myosins contains 2 IQ motifs, 2 MyTH4 ...
101-768 3.85e-115

class XXXV myosin, motor domain; This class of metazoan myosins contains 2 IQ motifs, 2 MyTH4 domains, a single FERM domain, and an SH3 domain. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276861 [Multi-domain]  Cd Length: 644  Bit Score: 380.66  E-value: 3.85e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  101 PSVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLITG 180
Cdd:cd14896     1 SSVLLCLKKRFHLGRIYTFGGPILLSLNPHRSLPLFSEEVLASYHPRKALNTTPHIFAIAASAYRLSQSTGQDQCILLSG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  181 ESGAGKTVNTKRVIQYFATVAVQGPEKKKEQASGKMqgsledqiiaanPLLEAYGNAKTVRNDNSSRFGKFIRIHFgTSG 260
Cdd:cd14896    81 HSGSGKTEAAKKIVQFLSSLYQDQTEDRLRQPEDVL------------PILESFGHAKTILNANASRFGQVLRLHL-QHG 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  261 KLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPELIEMtLITTNPYDFPMCSQGQI-TVASIDDKEELVATDTA 339
Cdd:cd14896   148 VIVGASVSHYLLETSRVVFQAQAERSFHVFYELLAGLDPEEREQ-LSLQGPETYYYLNQGGAcRLQGKEDAQDFEGLLKA 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  340 IDILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQRE--EQAEPDGTEEADKIGYLLGLnSADMLKALCYPRVKVGN-EFVT 416
Cdd:cd14896   227 LQGLGLCAEELTAIWAVLAAILQLGNICFSSSEREsqEVAAVSSWAEIHTAARLLQV-PPERLEGAVTHRVTETPyGRVS 305
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  417 KGQTVPQVYNSVSALSKSIYERMFLWMVVRINQMLDTKQQRNFF--IGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFN 494
Cdd:cd14896   306 RPLPVEGAIDARDALAKTLYSRLFTWLLKRINAWLAPPGEAESDatIGVVDAYGFEALRVNGLEQLCINLASERLQLFSS 385
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  495 HHMFVLEQEEYKKEGIVWEFIDfGMDLAACIELI-EKPLGIFSILEEECMFPKATDTSFKNKLYDQHlGKCNAFQKPK-- 571
Cdd:cd14896   386 QTLLAQEEEECQRELLPWVPIP-QPPRESCLDLLvDQPHSLLSILDDQTWLSQATDHTFLQKCHYHH-GDHPSYAKPQlp 463
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  572 -PAkgkaeahFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYppvveetgGGKKGGKKKGGSMQTVS 650
Cdd:cd14896   464 lPV-------FTVRHYAGTVTYQVHKFLNRNRDQLDPAVVEMLAQSQLQLVGSLF--------QEAEPQYGLGQGKPTLA 528
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  651 SQFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNAs 730
Cdd:cd14896   529 SRFQQSLGDLTARLGRSHVYFIHCLNPNPGKLPGLFDVGHVTEQLRQAGILEAIGTRSEGFPVRVPFQAFLARFGALGS- 607
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|
gi 288856329  731 vipEGQ--FIDNKKASEKLLGSIDVNHDEYRFGHTKVFFK 768
Cdd:cd14896   608 ---ERQeaLSDRERCGAILSQVLGAESPLYHLGATKVLLK 644
MYSc_Myo45 cd14906
class XLV myosin, motor domain; The class XLVI myosins are comprised of slime molds ...
102-730 8.20e-111

class XLV myosin, motor domain; The class XLVI myosins are comprised of slime molds Dictyostelium and Polysphondylium. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276871 [Multi-domain]  Cd Length: 715  Bit Score: 370.85  E-value: 8.20e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  102 SVLYNLKERYAAWMIYTYSGLFCATVNPYKWLP-VYDAEVVAAYRGKKRM-EAPPHIFSVSDNAYQFMLTDRENQSVLIT 179
Cdd:cd14906     2 IILNNLGKRYKSDSIYTYIGNVLISINPYKDISsIYSNLILNEYKDINQNkSPIPHIYAVALRAYQSMVSEKKNQSIIIS 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  180 GESGAGKTVNTKRVIQYFatVAVQGPEKKKEQASGKMQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHF-GT 258
Cdd:cd14906    82 GESGSGKTEASKTILQYL--INTSSSNQQQNNNNNNNNNSIEKDILTSNPILEAFGNSRTTKNHNSSRFGKFLKIEFrSS 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  259 SGKLASADIETYLLEKSRVTFQlPDER--GYHIFYQMMTNHKPELIEMTLITTNPYDFPMCSQGQITVASI--------- 327
Cdd:cd14906   160 DGKIDGASIETYLLEKSRISHR-PDNInlSYHIFYYLVYGASKDERSKWGLNNDPSKYRYLDARDDVISSFksqssnkns 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  328 ------DDKEELVATDTAIDILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQ---REEQAEPDGTEEADKIGYLLGLNSAD 398
Cdd:cd14906   239 nhnnktESIESFQLLKQSMESMSINKEQCDAIFLSLAAILHLGNIEFEEDSdfsKYAYQKDKVTASLESVSKLLGYIESV 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  399 MLKALCYPRVKVGNE--FVTKGQTVPQVYNSVSALSKSIYERMFLWMVVRIN-QMLDTKQQR----------NFFIGVLD 465
Cdd:cd14906   319 FKQALLNRNLKAGGRgsVYCRPMEVAQSEQTRDALSKSLYVRLFKYIVEKINrKFNQNTQSNdlaggsnkknNLFIGVLD 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  466 IAGFEIFDFNSMEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIVWEFIDFgMDLAACIELIE-KPLGIFSILEEECMF 544
Cdd:cd14906   399 IFGFENLSSNSLEQLLINFTNEKLQQQFNLNVFENEQKEYLSEGIPWSNSNF-IDNKECIELIEkKSDGILSLLDDECIM 477
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  545 PKATDTSFKNKlYDQHLGKCNAFQKPKPAKGKaeahFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATL 624
Cdd:cd14906   478 PKGSEQSLLEK-YNKQYHNTNQYYQRTLAKGT----LGIKHFAGDVTYQTDGWLEKNRDSLYSDVEDLLLASSNFLKKSL 552
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  625 YPPVVEETGGGKKGGKKKGgsmqTVSSQFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGI 704
Cdd:cd14906   553 FQQQITSTTNTTKKQTQSN----TVSGQFLEQLNQLIQTINSTSVHYIRCIKPNQTMDCNNFNNVHVLSQLRNVGVLNTI 628
                         650       660
                  ....*....|....*....|....*.
gi 288856329  705 RICRKGFPSRILYADFKQRYKVLNAS 730
Cdd:cd14906   629 KVRKMGYSYRRDFNQFFSRYKCIVDM 654
MYSc_Myo19 cd14880
class XIX myosin, motor domain; Monomeric myosin-XIX (Myo19) functions as an actin-based motor ...
102-727 1.17e-110

class XIX myosin, motor domain; Monomeric myosin-XIX (Myo19) functions as an actin-based motor for mitochondrial movement in vertebrate cells. It contains a variable number of IQ domains. Human myo19 contains a motor domain, three IQ motifs, and a short tail. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276846 [Multi-domain]  Cd Length: 658  Bit Score: 368.41  E-value: 1.17e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  102 SVLYNLKERYAAWMIYTYSGLFCATVNPYKWLP-VYDAEVVAAYRGKKRMEA-PPHIFSVSDNAYQFMLTDRE--NQSVL 177
Cdd:cd14880     2 TVLRCLQARYTADTFYTNAGCTLVALNPFKPVPqLYSPELMREYHAAPQPQKlKPHIFTVGEQTYRNVKSLIEpvNQSIV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  178 ITGESGAGKTVNTKRVIQYFATVAVQGPEKKkeqaSGKMQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFG 257
Cdd:cd14880    82 VSGESGAGKTWTSRCLMKFYAVVAASPTSWE----SHKIAERIEQRILNSNPVMEAFGNACTLRNNNSSRFGKFIQLQLN 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  258 TSGKLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTN-HKPELIEMTLITTNPYDFPMCSQGQItvasidDKEELVAT 336
Cdd:cd14880   158 RAQQMTGAAVQTYLLEKTRVACQAPSERNFHIFYQICKGaSADERLQWHLPEGAAFSWLPNPERNL------EEDCFEVT 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  337 DTAIDILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQREEQAEP--DGTEEADKI-GYLLGLNSADMLKALCYPRVKVGne 413
Cdd:cd14880   232 REAMLHLGIDTPTQNNIFKVLAGLLHLGNIQFADSEDEAQPCQpmDDTKESVRTsALLLKLPEDHLLETLQIRTIRAG-- 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  414 fvtKGQTVPQVYNSVS-------ALSKSIYERMFLWMVVRINQMLDTKQQR-NFFIGVLDIAGFEIFDFNSMEQLCINFT 485
Cdd:cd14880   310 ---KQQQVFKKPCSRAecdtrrdCLAKLIYARLFDWLVSVINSSICADTDSwTTFIGLLDVYGFESFPENSLEQLCINYA 386
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  486 NEKLQQFFNHHMFVLEQEEYKKEGIVWEFIDFgMDLAACIELIE-KPLGIFSILEEECMFPKATDTSFKNKLYDQHLGKC 564
Cdd:cd14880   387 NEKLQQHFVAHYLRAQQEEYAVEGLEWSFINY-QDNQTCLDLIEgSPISICSLINEECRLNRPSSAAQLQTRIESALAGN 465
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  565 NAFQKPKPAKgkaEAHFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYpPVVEETGGGKKGGKKKGG 644
Cdd:cd14880   466 PCLGHNKLSR---EPSFIVVHYAGPVRYHTAGLVEKNKDPVPPELTRLLQQSQDPLLQKLF-PANPEEKTQEEPSGQSRA 541
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  645 SMQTVSSQFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRY 724
Cdd:cd14880   542 PVLTVVSKFKASLEQLLQVLHSTTPHYIRCIKPNSQCQAQTFLQEEVLSQLEACGLVETIHISAAGFPIRVSHQNFVERY 621

                  ...
gi 288856329  725 KVL 727
Cdd:cd14880   622 KLL 624
MYSc_Myo25 cd14886
class XXV myosin, motor domain; These myosins are MyTH-FERM myosins that play a role in cell ...
107-768 4.32e-109

class XXV myosin, motor domain; These myosins are MyTH-FERM myosins that play a role in cell adhesion and filopodia formation. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276851  Cd Length: 650  Bit Score: 363.44  E-value: 4.32e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  107 LKERYAAWMIYTYSGLFCATVNPYKWLP-VYDAEVVAAYRGKKRM-----EAPPHIFSVSDNAYQFMLTDRENQSVLITG 180
Cdd:cd14886     7 LRDRFAKDKIYTYAGKLLVALNPFKQIRnLYGTEVIGRYRQADTSrgfpsDLPPHSYAVAQSALNGLISDGISQSCIVSG 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  181 ESGAGKTVNTKRVIQYFATVAVQGPEKkkeqasgkmqgsLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTSG 260
Cdd:cd14886    87 ESGAGKTETAKQLMNFFAYGHSTSSTD------------VQSLILGSNPLLESFGNAKTLRNNNSSRFGKFIKLLVGPDG 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  261 KLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPELIE-MTLITTNPYDFPMCSQGqITVASIDDKEELVATDTA 339
Cdd:cd14886   155 GLKGGKITSYMLELSRIEFQSTNERNYHIFYQCIKGLSPEEKKsLGFKSLESYNFLNASKC-YDAPGIDDQKEFAPVRSQ 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  340 IDILgFNNEEKMGIYKFTGAVLHHGNMKFKQKQR---EEQAEPDGTEEADKIGYLLGLNSADMLKALCYPRVKVGNEFVT 416
Cdd:cd14886   234 LEKL-FSKNEIDSFYKCISGILLAGNIEFSEEGDmgvINAAKISNDEDFGKMCELLGIESSKAAQAIITKVVVINNETII 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  417 KGQTVPQVYNSVSALSKSIYERMFLWMVVRINQMLDTKQQRNFFIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFNHH 496
Cdd:cd14886   313 SPVTQAQAEVNIRAVAKDLYGALFELCVDTLNEIIQFDADARPWIGILDIYGFEFFERNTYEQLLINYANERLQQYFINQ 392
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  497 MFVLEQEEYKKEGIVWEFIDFgMDLAACIELIEKP-LGIFSILEEECMFPKATDTSFKNklydqhlgKCNAFQKPK---P 572
Cdd:cd14886   393 VFKSEIQEYEIEGIDHSMITF-TDNSNVLAVFDKPnLSIFSFLEEQCLIQTGSSEKFTS--------SCKSKIKNNsfiP 463
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  573 AKGkAEAHFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYPPVVEETGGGKKggkkkggsmQTVSSQ 652
Cdd:cd14886   464 GKG-SQCNFTIVHTAATVTYNTEEFVDKNKHKLSVDILELLMGSTNPIVNKAFSDIPNEDGNMKG---------KFLGST 533
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  653 FRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVL---NA 729
Cdd:cd14886   534 FQLSIDQLMKTLSATKSHFIRCIKTNQDKVPNKYETKSVYNQLISLSIFESIQTIHRGFAYNDTFEEFFHRNKILishNS 613
                         650       660       670
                  ....*....|....*....|....*....|....*....
gi 288856329  730 SVIPEGQfiDNKKASEKLLGSIDVNHDEYRFGHTKVFFK 768
Cdd:cd14886   614 SSQNAGE--DLVEAVKSILENLGIPCSDYRIGKTKVFLR 650
MYSc_Myo38 cd14899
class XXXVIII myosin; The class XXXVIII myosins are comprised of Stramenopiles. Not much is ...
102-725 1.47e-107

class XXXVIII myosin; The class XXXVIII myosins are comprised of Stramenopiles. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276864 [Multi-domain]  Cd Length: 717  Bit Score: 361.34  E-value: 1.47e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  102 SVLYNLKERYAAWMIYTYSGLFCATVNPYKWLP-VYDAEVVAAYR-------GKKRMEA---PPHIFSVSDNAYQFMLTD 170
Cdd:cd14899     2 SILNALRLRYERHAIYTHIGDILISINPFQDLPqLYGDEILRGYAydhnsqfGDRVTSTdprEPHLFAVARAAYIDIVQN 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  171 RENQSVLITGESGAGKTVNTKRVIQYFATVAVQG-----PEKKKEQASGKMQGSLEDQIIAANPLLEAYGNAKTVRNDNS 245
Cdd:cd14899    82 GRSQSILISGESGAGKTEATKIIMTYFAVHCGTGnnnltNSESISPPASPSRTTIEEQVLQSNPILEAFGNARTVRNDNS 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  246 SRFGKFIRIHF-GTSGKLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNH----KPELIEMTLITTNPYDFPMCSQG 320
Cdd:cd14899   162 SRFGKFIELRFrDERRRLAGARIRTYLLEKIRVIKQAPHERNFHIFYELLSADnncvSKEQKQVLALSGGPQSFRLLNQS 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  321 QITVA--SIDDKEELVATDTAIDILGFNNEEKMGIYKFTGAVLHHGNMKFKQ--KQREEQAEPDGTEEA----------D 386
Cdd:cd14899   242 LCSKRrdGVKDGVQFRATKRAMQQLGMSEGEIGGVLEIVAAVLHMGNVDFEQipHKGDDTVFADEARVMssttgafdhfT 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  387 KIGYLLGLNSADMLKALCYPRVKVGNEFVTKGQTVPQVYNSVSALSKSIYERMFLWMVVRINQML--------------- 451
Cdd:cd14899   322 KAAELLGVSTEALDHALTKRWLHASNETLVVGVDVAHARNTRNALTMECYRLLFEWLVARVNNKLqrqasapwgadesdv 401
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  452 DTKQQRNFFIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIVWEFIDFGMDlAACIELIE-K 530
Cdd:cd14899   402 DDEEDATDFIGLLDIFGFEDMAENSFEQLCINYANEALQHQFNQYIFEEEQRLYRDEGIRWSFVDFPNN-RACLELFEhR 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  531 PLGIFSILEEECMFPKATDTSFKNKLYDQHLGKCNAFQKPKPAKGKAEAHFSLVHYAGTVDYNISGWLDKNKDPLNESVV 610
Cdd:cd14899   481 PIGIFSLTDQECVFPQGTDRALVAKYYLEFEKKNSHPHFRSAPLIQRTTQFVVAHYAGCVTYTIDGFLAKNKDSFCESAA 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  611 QLYQKSSVKLLATLYPPVVEETGGGKKGGKKKGGSMQ----------TVSSQFRENLGKLMTNLRSTHPHFVRCLIPNES 680
Cdd:cd14899   561 QLLAGSSNPLIQALAAGSNDEDANGDSELDGFGGRTRrraksaiaavSVGTQFKIQLNELLSTVRATTPRYVRCIKPNDS 640
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*
gi 288856329  681 KTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYK 725
Cdd:cd14899   641 HVGSLFQSTRVVEQLRSGGVLEAVRVARAGFPVRLTHKQFLGRYR 685
MYSc_Myo13 cd14875
class XIII myosin, motor domain; These myosins have an N-terminal motor domain, a light-chain ...
102-768 7.62e-102

class XIII myosin, motor domain; These myosins have an N-terminal motor domain, a light-chain binding domain, and a C-terminal GPA/Q-rich domain. There is little known about the function of this myosin class. Two of the earliest members identified in this class are green alga Acetabularia cliftonii, Aclmyo1 and Aclmyo2. They are striking with their short tail of Aclmyo1 of 18 residues and the maximum of 7 IQ motifs in Aclmyo2. It is thought that these myosins are involved in organelle transport and tip growth. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276842 [Multi-domain]  Cd Length: 664  Bit Score: 342.95  E-value: 7.62e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  102 SVLYNLKERYAAWMI-YTYSGLFCATVNPYKWLPVYDAEVVAAYRG--KKRMeAPPHIFSVSDNAY-QFMLTDRENQSVL 177
Cdd:cd14875     2 TLLHCIKERFEKLHQqYSLMGEMVLSVNPFRLMPFNSEEERKKYLAlpDPRL-LPPHIWQVAHKAFnAIFVQGLGNQSVV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  178 ITGESGAGKTVNTKRVIQYFAtvavqgpEKKKEQASGKMQGSLEDQIIA----ANPLLEAYGNAKTVRNDNSSRFGKFIR 253
Cdd:cd14875    81 ISGESGSGKTENAKMLIAYLG-------QLSYMHSSNTSQRSIADKIDEnlkwSNPVMESFGNARTVRNDNSSRFGKYIK 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  254 IHF-GTSGKLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPELIEMTLITTNPYDFPMCSQGQITV------AS 326
Cdd:cd14875   154 LYFdPTSGVMVGGQTVTYLLEKSRIIMQSPGERNYHIFYEMLAGLSPEEKKELGGLKTAQDYKCLNGGNTFVrrgvdgKT 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  327 IDDKEELVATDTAIDILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQREEQAEPDGTEEADKIGyLLGLNSADMLKalCYp 406
Cdd:cd14875   234 LDDAHEFQNVRHALSMIGVELETQNSIFRVLASILHLMEVEFESDQNDKAQIADETPFLTACR-LLQLDPAKLRE--CF- 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  407 RVKVGNEFVTKGQTVPQVYNSVSALSKSIYERMFLWMVVRINQMLDTKQQRNF--FIGVLDIAGFEIFDFNSMEQLCINF 484
Cdd:cd14875   310 LVKSKTSLVTILANKTEAEGFRNAFCKAIYVGLFDRLVEFVNASITPQGDCSGckYIGLLDIFGFENFTRNSFEQLCINY 389
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  485 TNEKLQQFFNHHMFVLEQEEYKKEGIVWEFIDFGmDLAACIELIE-KPLGIFSILEEECMFPKATDTSFKNKLYDQHLGK 563
Cdd:cd14875   390 ANESLQNHYNKYTFINDEEECRREGIQIPKIEFP-DNSECVNMFDqKRTGIFSMLDEECNFKGGTTERFTTNLWDQWANK 468
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  564 CNAFQKPKPAkgkAEAHFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYPpvveetgggkkGGKKKG 643
Cdd:cd14875   469 SPYFVLPKST---IPNQFGVNHYAAFVNYNTDEWLEKNTDALKEDMYECVSNSTDEFIRTLLS-----------TEKGLA 534
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  644 GSMQTVSSQFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADF-KQ 722
Cdd:cd14875   535 RRKQTVAIRFQRQLTDLRTELESTETQFIRCIKPNMEASPSFLDNLLVGSQLESAGVLQTIALKRQGYPVRRPIEQFcRY 614
                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|
gi 288856329  723 RYKVLNASVIPEGQFIDNKKASEKLLGS----IDVNHDEYRFGHTKVFFK 768
Cdd:cd14875   615 FYLIMPRSTASLFKQEKYSEAAKDFLAYyqrlYGWAKPNYAVGKTKVFLR 664
MYSc_Myo18 cd01386
class XVIII myosin, motor domain; Many members of this class contain a N-terminal PDZ domain ...
102-768 1.30e-94

class XVIII myosin, motor domain; Many members of this class contain a N-terminal PDZ domain which is commonly found in proteins establishing molecular complexes. The motor domain itself does not exhibit ATPase activity, suggesting that it functions as an actin tether protein. It also has two IQ domains that probably bind light chains or related calmodulins and a C-terminal tail with two sections of coiled-coil domains, which are thought to mediate homodimerization. The function of these myosins are largely unknown. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276837 [Multi-domain]  Cd Length: 689  Bit Score: 322.72  E-value: 1.30e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  102 SVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLITGE 181
Cdd:cd01386     2 SVLHTLRQRYGANLIHTYAGPSLIVINPRHPLAVYSEKVAKMFKGCRREDMPPHIYASAQSAYRAMLMSRRDQSIVLLGR 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  182 SGAGKTVNTKRVIQYFATVAvqgpekkkeqASGKMQGSLEdQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTSGK 261
Cdd:cd01386    82 SGSGKTTNCRHILEYLVTAA----------GSVGGVLSVE-KLNAALTVLEAFGNVRTALNGNATRFSQLFSLDFDQAGQ 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  262 LASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPEL---IEMTLITTNPYDFPMCSQgqitvaSIDDKE----ELV 334
Cdd:cd01386   151 LASASIQTLLLERSRVARRPEGESNFNVFYYLLAGADAALrteLHLNQLAESNSFGIVPLQ------KPEDKQkaaaAFS 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  335 ATDTAIDILGFNNEEKMGIYKFTGAVLHHGN---MKFKQKQREEQAEPdgtEEADKIGYLLGLNSADMLKALCYPRVKVG 411
Cdd:cd01386   225 KLQAAMKTLGISEEEQRAIWSILAAIYHLGAagaTKAASAGRKQFARP---EWAQRAAYLLGCTLEELSSAIFKHHLSGG 301
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  412 NEFVTKGQTVPQVYNS------------VSALSKSIYERMFLWMVVRINQMLDTKQQRNFFIGVLDIAGFEIFDFN---- 475
Cdd:cd01386   302 PQQSTTSSGQESPARSssggpkltgveaLEGFAAGLYSELFAAVVSLINRSLSSSHHSTSSITIVDTPGFQNPAHSgsqr 381
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  476 --SMEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIVWEFIDFGMDLAACIELIEKPL---------------GIFSIL 538
Cdd:cd01386   382 gaTFEDLCHNYAQERLQLLFHERTFVAPLERYKQENVEVDFDLPELSPGALVALIDQAPqqalvrsdlrdedrrGLLWLL 461
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  539 EEECMFPKATDTSFKNKLYdQHLGKCNAFQKPKPAKgKAEA--HFSLVHYAGT--VDYNISGWLDKNK-DPLNESVVQLY 613
Cdd:cd01386   462 DEEALYPGSSDDTFLERLF-SHYGDKEGGKGHSLLR-RSEGplQFVLGHLLGTnpVEYDVSGWLKAAKeNPSAQNATQLL 539
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  614 QKSSVKLLAtlyppvveetgggkkggkkkgGSMQTVSSQFRENLGKLMTNLRSTHPHFVRCLIPN-----------ESKT 682
Cdd:cd01386   540 QESQKETAA---------------------VKRKSPCLQIKFQVDALIDTLRRTGLHFVHCLLPQhnagkderstsSPAA 598
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  683 PGLMENF-LVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVL----NASVIPEGQFIDNKKASEKLLGSIDVNHDE 757
Cdd:cd01386   599 GDELLDVpLLRSQLRGSQLLDALRLYRQGFPDHMPLGEFRRRFQVLapplTKKLGLNSEVADERKAVEELLEELDLEKSS 678
                         730
                  ....*....|.
gi 288856329  758 YRFGHTKVFFK 768
Cdd:cd01386   679 YRIGLSQVFFR 689
MYSc_Myo16 cd14878
class XVI myosin, motor domain; These XVI type myosins are also known as Neuronal ...
102-736 3.81e-94

class XVI myosin, motor domain; These XVI type myosins are also known as Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3/NYAP3. Myo16 is thought to play a regulatory role in cell cycle progression and has been recently implicated in Schizophrenia. Class XVI myosins are characterized by an N-terminal ankyrin repeat domain and some with chitin synthase domains that arose independently from the ones in the class XVII fungal myosins. They bind protein phosphatase 1 catalytic subunits 1alpha/PPP1CA and 1gamma/PPP1CC. Human Myo16 interacts with ACOT9, ARHGAP26 and PIK3R2 and with components of the WAVE1 complex, CYFIP1 and NCKAP1. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276844 [Multi-domain]  Cd Length: 656  Bit Score: 320.22  E-value: 3.81e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  102 SVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYR---GKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLI 178
Cdd:cd14878     2 SLLYEIQKRFGNNQIYTFIGDILLLVNPYKELPIYSTMVSQLYLsssGQLCSSLPPHLFSCAERAFHQLFQERRPQCFIL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  179 TGESGAGKTVNTKRVIQYFATvavqgpekkkeqASGKMQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGT 258
Cdd:cd14878    82 SGERGSGKTEASKQIMKHLTC------------RASSSRTTFDSRFKHVNCILEAFGHAKTTLNDLSSCFIKYFELQFCE 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  259 SGK-LASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPELiEMTLITTNPYDFPMCSQGQ----ITVASIDDKEEL 333
Cdd:cd14878   150 RKKhLTGARIYTYMLEKSRLVSQPPGQSNFLIFYLLMDGLSAEE-KYGLHLNNLCAHRYLNQTMredvSTAERSLNREKL 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  334 VATDTAIDILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQREEQAEPDGTEEADKIGYLLGLNSADMLKALCYPRVKVGNE 413
Cdd:cd14878   229 AVLKQALNVVGFSSLEVENLFVILSAILHLGDIRFTALTEADSAFVSDLQLLEQVAGMLQVSTDELASALTTDIQYFKGD 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  414 FVTKGQTVPQVYNSVSALSKSIYERMFLWMVVRINQML----DTKQQRNFFIGVLDIAGFEIFDFNSMEQLCINFTNEKL 489
Cdd:cd14878   309 MIIRRHTIQIAEFYRDLLAKSLYSRLFSFLVNTVNCCLqsqdEQKSMQTLDIGILDIFGFEEFQKNEFEQLCVNMTNEKM 388
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  490 QQFFNHHMFVLEQEEYKKEGIVWEFI-DFGMDLAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQ-HLGKCNAF 567
Cdd:cd14878   389 HHYINEVLFLQEQTECVQEGVTMETAySPGNQTGVLDFFFQKPSGFLSLLDEESQMIWSVEPNLPKKLQSLlESSNTNAV 468
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  568 QKPK-------PAKGKAEAhFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYppvveetgggkkggk 640
Cdd:cd14878   469 YSPMkdgngnvALKDQGTA-FTVMHYAGRVMYEIVGAIEKNKDSLSQNLLFVMKTSENVVINHLF--------------- 532
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  641 kkGGSMQTVSSQFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADF 720
Cdd:cd14878   533 --QSKLVTIASQLRKSLADIIGKLQKCTPHFIHCIKPNNSKLPDTFDNFYVSAQLQYIGVLEMVKIFRYGYPVRLSFSDF 610
                         650
                  ....*....|....*.
gi 288856329  721 KQRYKVLnASVIPEGQ 736
Cdd:cd14878   611 LSRYKPL-ADTLLGEK 625
MYSc_Myo24A cd14937
class XXIV A myosin, motor domain; These myosins have a 1-2 IQ motifs in their neck and a ...
103-768 1.99e-87

class XXIV A myosin, motor domain; These myosins have a 1-2 IQ motifs in their neck and a coiled-coil region in their C-terminal tail. The function of the class XXIV myosins remain elusive. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276897  Cd Length: 637  Bit Score: 300.01  E-value: 1.99e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  103 VLYNLKERYAAWMIYTYSGLFCATVNPYKwlpVYDAEVvAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLITGES 182
Cdd:cd14937     3 VLNMLALRYKKNYIYTIAEPMLISINPYQ---VIDVDI-NEYKNKNTNELPPHVYSYAKDAMTDFINTKTNQSIIISGES 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  183 GAGKTVNTKRVIQYFatvaVQGPEKKKEqasgkMQGSLEDqiiaANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTSGKL 262
Cdd:cd14937    79 GSGKTEASKLVIKYY----LSGVKEDNE-----ISNTLWD----SNFILEAFGNAKTLKNNNSSRYGKYIKIELDEYQNI 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  263 ASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPELIEMTLITTNPyDFPMCSQGQITVASIDDKEELVATDTAIDI 342
Cdd:cd14937   146 VSSSIEIFLLENIRVVSQEEEERGYHIFYQIFNGMSQELKNKYKIRSEN-EYKYIVNKNVVIPEIDDAKDFGNLMISFDK 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  343 LGFNNEEKMGIYKFTGAVLhHGNMKFKQ-----KQREEQAEPDGTEEADKIGYLLGLNSADMLKALCYPRVKVGNEFVTK 417
Cdd:cd14937   225 MNMHDMKDDLFLTLSGLLL-LGNVEYQEiekggKTNCSELDKNNLELVNEISNLLGINYENLKDCLVFTEKTIANQKIEI 303
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  418 GQTVPQVYNSVSALSKSIYERMFLWMVVRINQMLDTKQQRNFFIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFNHHM 497
Cdd:cd14937   304 PLSVEESVSICKSISKDLYNKIFSYITKRINNFLNNNKELNNYIGILDIFGFEIFSKNSLEQLLINIANEEIHSIYLYIV 383
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  498 FVLEQEEYKKEGIVWEFIDFGMDlAACIELIEKPLGIFSILEEECMFPKATDTSfknkLYDQHLGKCNAFQKPKPAKGKA 577
Cdd:cd14937   384 YEKETELYKAEDILIESVKYTTN-ESIIDLLRGKTSIISILEDSCLGPVKNDES----IVSVYTNKFSKHEKYASTKKDI 458
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  578 EAHFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYPPV-VEETGGGKkggkkkggsmQTVSSQFREN 656
Cdd:cd14937   459 NKNFVIKHTVSDVTYTITNFISKNKDILPSNIVRLLKVSNNKLVRSLYEDVeVSESLGRK----------NLITFKYLKN 528
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  657 LGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRIcRKGFPSRILYADFKQRYKVLNASVIPEGQ 736
Cdd:cd14937   529 LNNIISYLKSTNIYFIKCIKPNENKEKNNFNQKKVFPQLFSLSIIETLNI-SFFFQYKYTFDVFLSYFEYLDYSTSKDSS 607
                         650       660       670
                  ....*....|....*....|....*....|..
gi 288856329  737 FIDNKKASEKLLGSIDvnHDEYRFGHTKVFFK 768
Cdd:cd14937   608 LTDKEKVSMILQNTVD--PDLYKVGKTMVFLK 637
MYSc_Myo26 cd14887
class XXVI myosin, motor domain; These MyTH-FERM myosins are thought to be related to the ...
101-768 7.88e-87

class XXVI myosin, motor domain; These MyTH-FERM myosins are thought to be related to the other myosins that have a MyTH4 domain such as class III, VII, IX, X , XV, XVI, XVII, XX, XXII, XXV, and XXXIV. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276852  Cd Length: 725  Bit Score: 301.18  E-value: 7.88e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  101 PSVLYNLKERYAA--------WMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRE 172
Cdd:cd14887     1 PNLLENLYQRYNKayinkenrNCIYTYTGTLLIAVNPYRFFNLYDRQWISRFDTEANSRLVPHPFGLAEFAYCRLVRDRR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  173 NQSVLITGESGAGKTVNTKRVIQYFATVAvqgpekkkEQASGKMQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFI 252
Cdd:cd14887    81 SQSILISGESGAGKTETSKHVLTYLAAVS--------DRRHGADSQGLEARLLQSGPVLEAFGNAHTVLNANSSRFGKML 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  253 RIHFGTSGKLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNhkpELIEMTLITTNPYDFPMCSqgqitvasidDKEE 332
Cdd:cd14887   153 LLHFTGRGKLTRASVATYLLANERVVRIPSDEFSFHIFYALCNA---AVAAATQKSSAGEGDPEST----------DLRR 219
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  333 LVATDTAIDILGFNNEEkmgIYKFTGAVLHHGNMKFKQKQREEQAEPD-------GTEE--------------------- 384
Cdd:cd14887   220 ITAAMKTVGIGGGEQAD---IFKLLAAILHLGNVEFTTDQEPETSKKRkltsvsvGCEEtaadrshssevkclssglkvt 296
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  385 ----------ADKIGYLLGLNSADMLK-ALCYPRVKVGNEFVTKGQTvpqVYNSvSALSKSIYERMFLWMVVRINQMLDT 453
Cdd:cd14887   297 easrkhlktvARLLGLPPGVEGEEMLRlALVSRSVRETRSFFDLDGA---AAAR-DAACKNLYSRAFDAVVARINAGLQR 372
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  454 KQQRNF--------------FIGVLDIAGFEIF---DFNSMEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIVWEFI- 515
Cdd:cd14887   373 SAKPSEsdsdedtpsttgtqTIGILDLFGFEDLrnhSKNRLEQLCINYANERLHCFLLEQLILNEHMLYTQEGVFQNQDc 452
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  516 ---DFGMDLAAC--------IELIEKP--------------LGIFSILEEE-CMFPKATDTSFKNKLYDQHLGKCNA--- 566
Cdd:cd14887   453 safPFSFPLASTltsspsstSPFSPTPsfrsssafatspslPSSLSSLSSSlSSSPPVWEGRDNSDLFYEKLNKNIInsa 532
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  567 -FQKPKPAKGKAEAHFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKllatlyppVVEETGGGKKGGKKKGGS 645
Cdd:cd14887   533 kYKNITPALSRENLEFTVSHFACDVTYDARDFCRANREATSDELERLFLACSTY--------TRLVGSKKNSGVRAISSR 604
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  646 MQTVSSQFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYK 725
Cdd:cd14887   605 RSTLSAQFASQLQQVLKALQETSCHFIRCVKPNRVQEAGIFEDAYVHRQLRCSGMSDLLRVMADGFPCRLPYVELWRRYE 684
                         730       740       750       760
                  ....*....|....*....|....*....|....*....|....*
gi 288856329  726 vlnaSVIPEG--QFIDNKKASEKLLGSIDVNHDEYRFGHTKVFFK 768
Cdd:cd14887   685 ----TKLPMAlrEALTPKMFCKIVLMFLEINSNSYTFGKTKIFFR 725
MYSc_Myo37 cd14898
class XXXVII myosin, motor domain; The class XXXVIII myosins are comprised of fungi. Not much ...
102-731 6.38e-84

class XXXVII myosin, motor domain; The class XXXVIII myosins are comprised of fungi. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276863  Cd Length: 578  Bit Score: 287.95  E-value: 6.38e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  102 SVLYNLKERYAAWMIYTYSGLFCATVNPYKwlPVYDAEVVAAYRgKKRMEAPPHIFSVSDNAYQFMLTdRENQSVLITGE 181
Cdd:cd14898     2 ATLEILEKRYASGKIYTKSGLVFLALNPYE--TIYGAGAMKAYL-KNYSHVEPHVYDVAEASVQDLLV-HGNQTIVISGE 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  182 SGAGKTVNTKRVIQYFAtvavqgpekkkEQASGKMqgSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFgtSGK 261
Cdd:cd14898    78 SGSGKTENAKLVIKYLV-----------ERTASTT--SIEKLITAANLILEAFGNAKTQLNDNSSRFGKRIKLKF--DGK 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  262 LASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKpeliemtLITTNPYdFPMCSQGQITVASIDDKEELVATDTAID 341
Cdd:cd14898   143 ITGAKFETYLLEKSRVTHHEKGERNFHIFYQFCASKR-------LNIKNDF-IDTSSTAGNKESIVQLSEKYKMTCSAMK 214
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  342 ILGFNNEEKmgIYKFTGAVLHHGNMKFKQkqrEEQAEPDGTEEADKIGYLLGLNSADMLKALCYPRVKVGNEFVTKGQTV 421
Cdd:cd14898   215 SLGIANFKS--IEDCLLGILYLGSIQFVN---DGILKLQRNESFTEFCKLHNIQEEDFEESLVKFSIQVKGETIEVFNTL 289
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  422 PQVYNSVSALSKSIYERMFLWMVVRINQMLDTKQQRNffIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFNHHMFVLE 501
Cdd:cd14898   290 KQARTIRNSMARLLYSNVFNYITASINNCLEGSGERS--ISVLDIFGFEIFESNGLDQLCINWTNEKIQNDFIKKMFRAK 367
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  502 QEEYKKEGIVWEFIDFgMDLAACIELIEKPLGIFSILEEECMFPKAT--DTSFKNKLYDQHLGKCNAFQKPKpakgkaea 579
Cdd:cd14898   368 QGMYKEEGIEWPDVEF-FDNNQCIRDFEKPCGLMDLISEESFNAWGNvkNLLVKIKKYLNGFINTKARDKIK-------- 438
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  580 hfsLVHYAGTVDYNISGWLDKNKdplnesvvqlyQKSSVKLLATlyPPVVEEtgggkkggkkkgGSMQTVSSQFRENLGK 659
Cdd:cd14898   439 ---VSHYAGDVEYDLRDFLDKNR-----------EKGQLLIFKN--LLINDE------------GSKEDLVKYFKDSMNK 490
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 288856329  660 LMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASV 731
Cdd:cd14898   491 LLNSINETQAKYIKCIRPNEECRPWCFDRDLVSKQLAECGILETIRLSKQCFPQEIPKDRFEERYRILGITL 562
MYSc_Myo17 cd14879
class XVII myosin, motor domain; This fungal myosin which is also known as chitin synthase ...
107-767 6.17e-80

class XVII myosin, motor domain; This fungal myosin which is also known as chitin synthase uses its motor domain to tether its vesicular cargo to peripheral actin. It works in opposition to dynein, contributing to the retention of Mcs1 vesicles at the site of cell growth and increasing vesicle fusion necessary for polarized growth. Class 17 myosins consist of a N-terminal myosin motor domain with Cyt-b5, chitin synthase 2, and a DEK_C domains at it C-terminus. The chitin synthase region contains several transmembrane domains by which myosin 17 is thought to bind secretory vesicles. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276845 [Multi-domain]  Cd Length: 647  Bit Score: 278.66  E-value: 6.17e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  107 LKERYAAWMIYTY---SGLFCatVNPYKWLPVYDAEVVAAYR-------GKKRMEAPPHIFSVSDNAYQFMLTDRENQSV 176
Cdd:cd14879    10 LASRFRSDLPYTRlgsSALVA--VNPYKYLSSNSDASLGEYGseyydttSGSKEPLPPHAYDLAARAYLRMRRRSEDQAV 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  177 LITGESGAGKTVNTKRVIQYFATVAVQGPEKKKeqasgkmqgsLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHF 256
Cdd:cd14879    88 VFLGETGSGKSESRRLLLRQLLRLSSHSKKGTK----------LSSQISAAEFVLDSFGNAKTLTNPNASRFGRYTELQF 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  257 GTSGKLASADIETYLLEKSRVTfQLP-DERGYHIFYQMMTNHKPELIEmTLITTNPYDFPM-----CSQGQITVASiDDK 330
Cdd:cd14879   158 NERGRLIGAKVLDYRLERSRVA-SVPtGERNFHVFYYLLAGASPEERQ-HLGLDDPSDYALlasygCHPLPLGPGS-DDA 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  331 EELVATDTAIDILGFNNEEKMGIYKFTGAVLHHGNMKFKQkqreeqaEPDGTEEA---------DKIGYLLGLNSADMLK 401
Cdd:cd14879   235 EGFQELKTALKTLGFKRKHVAQICQLLAAILHLGNLEFTY-------DHEGGEESavvkntdvlDIVAAFLGVSPEDLET 307
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  402 ALCYPRVKVGNEFVTkgqtvpqVY-NSVSA------LSKSIYERMFLWMVVRINQML-DTKQQRNFFIGVLDIAGFEIFD 473
Cdd:cd14879   308 SLTYKTKLVRKELCT-------VFlDPEGAaaqrdeLARTLYSLLFAWVVETINQKLcAPEDDFATFISLLDFPGFQNRS 380
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  474 ---FNSMEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIVWEFIDFgMDLAACIELI-EKPLGIFSILEEEC-MFPKAT 548
Cdd:cd14879   381 stgGNSLDQFCVNFANERLHNYVLRSFFERKAEELEAEGVSVPATSY-FDNSDCVRLLrGKPGGLLGILDDQTrRMPKKT 459
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  549 DTSFKNKLYDQHLGKCNAFQKPKPAKGKAEAHFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLyqkssvkLLATlyppv 628
Cdd:cd14879   460 DEQMLEALRKRFGNHSSFIAVGNFATRSGSASFTVNHYAGEVTYSVEGFLERNGDVLSPDFVNL-------LRGA----- 527
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  629 veetgggkkggkkkggsmqtvsSQFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICR 708
Cdd:cd14879   528 ----------------------TQLNAALSELLDTLDRTRLWSVFCIRPNDSQLPNSFDKRRVKAQIRSLGLPELAARLR 585
                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 288856329  709 KGFPSRILYADFKQRYKvlnasviPEGQFIDNKKASEKLLGSIDVNHDEYRFGHTKVFF 767
Cdd:cd14879   586 VEYVVSLEHAEFCERYK-------STLRGSAAERIRQCARANGWWEGRDYVLGNTKVFL 637
MYSc_Myo23 cd14884
class XXIII myosin, motor domain; These myosins are predicted to have a neck region with 1-2 ...
101-716 1.04e-70

class XXIII myosin, motor domain; These myosins are predicted to have a neck region with 1-2 IQ motifs and a single MyTH4 domain in its C-terminal tail. The lack of a FERM domain here is odd since MyTH4 domains are usually found alongside FERM domains where they bind to microtubules. At any rate these Class XXIII myosins are still proposed to function in the apicomplexan microtubule cytoskeleton. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276850 [Multi-domain]  Cd Length: 685  Bit Score: 252.52  E-value: 1.04e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  101 PSVLYNLKERYAAWMIYTYSGLFCATVNPYKWLP-VYDAEVVAAYRGKKRMEA-------PPHIFSVSDNAYQFMLTDRE 172
Cdd:cd14884     1 PNVLQNLKNRYLKNKIYTFHASLLLALNPYKPLKeLYDQDVMNVYLHKKSNSAasaapfpKAHIYDIANMAYKNMRGKLK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  173 NQSVLITGESGAGKTVNTKRVIQYFATVAVQgpekkkeqasgKMQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFI 252
Cdd:cd14884    81 RQTIVVSGHSGSGKTENCKFLFKYFHYIQTD-----------SQMTERIDKLIYINNILESMSNATTIKNNNSSRCGRIN 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  253 RIHFGT---------SGKLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPELIEMTLITTN--PYDFPMCSQGQ 321
Cdd:cd14884   150 LLIFEEventqknmfNGCFRNIKIKILLLEINRCIAHNFGERNFHVFYQVLRGLSDEDLARRNLVRNcgVYGLLNPDESH 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  322 ----------ITVASIDDKEELVATDTA-----IDILGFNNEEKMGIYKF---TGAVLHHGNMKFKQKQReeqaepdgte 383
Cdd:cd14884   230 qkrsvkgtlrLGSDSLDPSEEEKAKDEKnfvalLHGLHYIKYDERQINEFfdiIAGILHLGNRAYKAAAE---------- 299
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  384 eadkigyLLGLNSADMLKALCYPRVKVGNEFVTKGQTVPQVYNSVSALSKSIYERMFLWMVVRINQML------------ 451
Cdd:cd14884   300 -------CLQIEEEDLENVIKYKNIRVSHEVIRTERRKENATSTRDTLIKFIYKKLFNKIIEDINRNVlkckekdesdne 372
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  452 DTKQQRNFFIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIVW--EFIDFGMDLAACIELIE 529
Cdd:cd14884   373 DIYSINEAIISILDIYGFEELSGNDFDQLCINLANEKLNNYYINNEIEKEKRIYARENIICcsDVAPSYSDTLIFIAKIF 452
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  530 KPLGIFSILEEECMfpKATDTSFKNKLYD----QHLGKCNAFQK--PKPAKGKAEAH------FSLVHYAGTVDYNISGW 597
Cdd:cd14884   453 RRLDDITKLKNQGQ--KKTDDHFFRYLLNnerqQQLEGKVSYGFvlNHDADGTAKKQnikkniFFIRHYAGLVTYRINNW 530
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  598 LDKNKDPLNESVVQLYQKSSVKLLatlyppvveetggGKKGGKKKGGSMQTVSSQFRENLGKLMTNLRSTHPHFVRCLIP 677
Cdd:cd14884   531 IDKNSDKIETSIETLISCSSNRFL-------------REANNGGNKGNFLSVSKKYIKELDNLFTQLQSTDMYYIRCFLP 597
                         650       660       670
                  ....*....|....*....|....*....|....*....
gi 288856329  678 NESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRIL 716
Cdd:cd14884   598 NAKMLPNTFKRLLVYRQLKQCGSNEMIKILNRGLSHKIP 636
MYSc_Myo20 cd14881
class XX myosin, motor domain; These class 20 myosins are primarily insect myosins with such ...
174-757 7.10e-70

class XX myosin, motor domain; These class 20 myosins are primarily insect myosins with such members as Drosophila, Daphnia, and mosquitoes. These myosins contain a single IQ motif in the neck region. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276847 [Multi-domain]  Cd Length: 633  Bit Score: 248.49  E-value: 7.10e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  174 QSVLITGESGAGKTVNTKRVIQYFATVAVQGPEKK--KEQAsgkmqgsledqiiAANPLLEAYGNAKTVRNDNSSRFGKF 251
Cdd:cd14881    69 QAIILSGTSGSGKTYASMLLLRQLFDVAGGGPETDafKHLA-------------AAFTVLRSLGSAKTATNSESSRIGHF 135
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  252 IRIHFgTSGKLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKP-ELIEMTLITTNPYDFPMCSQGQITVASIDDK 330
Cdd:cd14881   136 IEVQV-TDGALYRTKIHCYFLDQTRVIRPLPGEKNYHIFYQMLAGLSQeERVKLHLDGYSPANLRYLSHGDTRQNEAEDA 214
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  331 EELVATDTAIDILGFNNEEKMGIYkftGAVLHHGNMKFKQKQrEEQAEPDGTEEADKIGYLLGLNSADMLKALcYPRVKV 410
Cdd:cd14881   215 ARFQAWKACLGILGIPFLDVVRVL---AAVLLLGNVQFIDGG-GLEVDVKGETELKSVAALLGVSGAALFRGL-TTRTHN 289
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  411 gnefvTKGQTV-----PQVYNSV-SALSKSIYERMFLWMVVRINQMLD-----TKQQRNFFIGVLDIAGFEIFDFNSMEQ 479
Cdd:cd14881   290 -----ARGQLVksvcdANMSNMTrDALAKALYCRTVATIVRRANSLKRlgstlGTHATDGFIGILDMFGFEDPKPSQLEH 364
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  480 LCINFTNEKLQQFFNHHMFVLEQEEYKKEGIVWEF-IDFgMDLAACIELIEK-PLGIFSILEEECMfPKATDTSFKNKLY 557
Cdd:cd14881   365 LCINLCAETMQHFYNTHIFKSSIESCRDEGIQCEVeVDY-VDNVPCIDLISSlRTGLLSMLDVECS-PRGTAESYVAKIK 442
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  558 DQHLGKCNAFQkPKPAKGKAeahFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLlatlyppvveetgggkk 637
Cdd:cd14881   443 VQHRQNPRLFE-AKPQDDRM---FGIRHFAGRVVYDASDFLDTNRDVVPDDLVAVFYKQNCNF----------------- 501
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  638 ggkkkggSMQTVSSQFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILY 717
Cdd:cd14881   502 -------GFATHTQDFHTRLDNLLRTLVHARPHFVRCIRSNTTETPNHFDRGTVVRQIRSLQVLETVNLMAGGYPHRMRF 574
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|
gi 288856329  718 ADFKQRYKVLnASVIPEGQFIDNKKASEKLLGSIDVNHDE 757
Cdd:cd14881   575 KAFNARYRLL-APFRLLRRVEEKALEDCALILQFLEAQPP 613
MYSc_Myo12 cd14874
class XXXIII myosin, motor domain; Little is known about the XXXIII class of myosins. They ...
103-768 9.96e-63

class XXXIII myosin, motor domain; Little is known about the XXXIII class of myosins. They are found predominately in nematodes. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276841 [Multi-domain]  Cd Length: 628  Bit Score: 227.45  E-value: 9.96e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  103 VLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYrgkkrmeappHIFSVSDNAYQFMLTDREN-QSVLITGE 181
Cdd:cd14874     3 IAQNLHERFKKGQTYTKASNVLVFVNDFNKLSIQDQLVIKKC----------HISGVAENALDRIKSMSSNaESIVFGGE 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  182 SGAGKTVNTKRVIQYFATvavqgpeKKKEQASGKMQGSLEDqiiaanpLLEAYGNAKTVRNDNSSRFGKFIRIHFGTSGK 261
Cdd:cd14874    73 SGSGKSYNAFQVFKYLTS-------QPKSKVTTKHSSAIES-------VFKSFGCAKTLKNDEATRFGCSIDLLYKRNVL 138
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  262 LASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPELIEMTLITtNPYDFPMCSQGQITVASIDDKEELVATDTAID 341
Cdd:cd14874   139 TGLNLKYTVPLEVPRVISQKPGERNFNVFYEVYHGLNDEMKAKFGIK-GLQKFFYINQGNSTENIQSDVNHFKHLEDALH 217
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  342 ILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQ----REEQAEPDGTEEADKIGYLLGLNsADMLKALCYPRVKVGNEFvtk 417
Cdd:cd14874   218 VLGFSDDHCISIYKIISTILHIGNIYFRTKRnpnvEQDVVEIGNMSEVKWVAFLLEVD-FDQLVNFLLPKSEDGTTI--- 293
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  418 gqTVPQVYNSVSALSKSIYERMFLWMVVRINQMLDTKQQrNFFIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFNHHM 497
Cdd:cd14874   294 --DLNAALDNRDSFAMLIYEELFKWVLNRIGLHLKCPLH-TGVISILDHYGFEKYNNNGVEEFLINSVNERIENLFVKHS 370
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  498 FVLEQEEYKKEGIVwefIDFGM----DLAACIELI-EKPLGIFSILEEECMFPKATDTSFknklydqhLGKCNAFQKPKP 572
Cdd:cd14874   371 FHDQLVDYAKDGIS---VDYKVpnsiENGKTVELLfKKPYGLLPLLTDECKFPKGSHESY--------LEHCNLNHTDRS 439
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  573 AKGKAEA----HFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYPPVVEETGGGkkggkkkggsMQT 648
Cdd:cd14874   440 SYGKARNkerlEFGVRHCIGTTWYNVTDFFSRNKRIISLSAVQLLRSSKNPIIGLLFESYSSNTSDM----------IVS 509
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  649 VSSQFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLN 728
Cdd:cd14874   510 QAQFILRGAQEIADKINGSHAHFVRCIKSNNERQPKKFDIPLVNRQIKNLLLAELLSFRIKGYPVKISKTTFARQYRCLL 589
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|.
gi 288856329  729 ASVIPEGQfiDNKKASEKLLGSIDVNHDE-YRFGHTKVFFK 768
Cdd:cd14874   590 PGDIAMCQ--NEKEIIQDILQGQGVKYENdFKIGTEYVFLR 628
MYSc_Myo32 cd14893
class XXXII myosin, motor domain; Class XXXII myosins do not contain any IQ motifs, but ...
104-725 1.49e-58

class XXXII myosin, motor domain; Class XXXII myosins do not contain any IQ motifs, but possess tandem MyTH4 and FERM domains. The myosin classes XXX to XXXIV contain members from Phytophthora species and Hyaloperonospora parasitica. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276858  Cd Length: 741  Bit Score: 217.53  E-value: 1.49e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  104 LYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRM----------EAPPHIFSVSDNAYQFMLTDREN 173
Cdd:cd14893     4 LYTLRARYRMEQVYTWVDRVLVGVNPVTPLPIYTPDHMQAYNKSREQtplyekdtvnDAPPHVFALAQNALRCMQDAGED 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  174 QSVLITGESGAGKTVNTKRVIQYFATVAVQ-GPEKKKEQASGKMQgSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFI 252
Cdd:cd14893    84 QAVILLGGMGAGKSEAAKLIVQYLCEIGDEtEPRPDSEGASGVLH-PIGQQILHAFTILEAFGNAATRQNRNSSRFAKMI 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  253 RIHFGTSGKLASADIETYLLEKSRVTFQLPDERGYHIFYQMMT--NHKPELIEMTLITTNPYDFPMCSQG--QITVASID 328
Cdd:cd14893   163 SVEFSKHGHVIGGGFTTHYFEKSRVIDCRSHERNFHVFYQVLAgvQHDPTLRDSLEMNKCVNEFVMLKQAdpLATNFALD 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  329 --DKEELVATDTAIDIlgfNNEEKMGIYKFTGAVLHHGNMKF----KQKQREEQAEPDGTEEA------DKIGYLLGLNS 396
Cdd:cd14893   243 arDYRDLMSSFSALRI---RKNQRVEIVRIVAALLHLGNVDFvpdpEGGKSVGGANSTTVSDAqscalkDPAQILLAAKL 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  397 ADMLKALC--YPRV-----KVGNEFVT--KGQTVPQVYNSVSALSKSIYERMFLWMVVRINQML----DTKQQRNFFIG- 462
Cdd:cd14893   320 LEVEPVVLdnYFRTrqffsKDGNKTVSslKVVTVHQARKARDTFVRSLYESLFNFLVETLNGILggifDRYEKSNIVINs 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  463 ----VLDIAGFEIFD--FNSMEQLCINFTNEKLQQFFNHHMFV-----LEQEEYKKEG--IVWEFIDFGMDLAACIELIE 529
Cdd:cd14893   400 qgvhVLDMVGFENLTpsQNSFDQLCFNYWSEKVHHFYVQNTLAinfsfLEDESQQVENrlTVNSNVDITSEQEKCLQLFE 479
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  530 -KPLGIFSILEEECMFPKATDTSFKNKLYDQHlGKCNAFQKPKPAKGKAEAH----------FSLVHYAGTVDYNISGWL 598
Cdd:cd14893   480 dKPFGIFDLLTENCKVRLPNDEDFVNKLFSGN-EAVGGLSRPNMGADTTNEYlapskdwrllFIVQHHCGKVTYNGKGLS 558
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  599 DKNKDPLNESVVQLYQKSSVKLL-----ATLYPPVVEETGGGKKGGKKKGGSMQTVSSQFRE--NLGK------------ 659
Cdd:cd14893   559 SKNMLSISSTCAAIMQSSKNAVLhavgaAQMAAASSEKAAKQTEERGSTSSKFRKSASSAREskNITDsaatdvynqada 638
                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 288856329  660 LMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYK 725
Cdd:cd14893   639 LLHALNHTGKNFLVCIKPNETLEEGVFDSAYVMKQIRMNHLVELMQASRSIFTVHLTYGHFFRRYK 704
MYSc_Myo21 cd14882
class XXI myosin, motor domain; The myosins here are comprised of insects. Leishmania class ...
102-727 2.17e-58

class XXI myosin, motor domain; The myosins here are comprised of insects. Leishmania class XXI myosins do not group with them. Myo21, unlike other myosin proteins, contains UBA-like protein domains and has no structural or functional relationship with the myosins present in other organisms possessing cilia or flagella. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. They have diverse tails with IQ, WW, PX, and Tub domains. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276848  Cd Length: 642  Bit Score: 214.60  E-value: 2.17e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  102 SVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLITGE 181
Cdd:cd14882     2 NILEELRHRYLMGESYTFIGDILLSLNPNEIKQEYPQEFHAKYRCKSRSDNAPHIFSVADSAYQDMLHHEEPQHIILSGE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  182 SGAGKTVNTKRVIQYFATVavqgpekkkeqasGKMQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTSGK 261
Cdd:cd14882    82 SYSGKTTNARLLIKHLCYL-------------GDGNRGATGRVESSIKAILALVNAGTPLNADSTRCILQYQLTFGSTGK 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  262 LASADIETYLLEKSRVTFQLPDERGYHIFYQMM--TNHKPELIEMTLITTNPYDF---PMCSQGQITVASIDDKEELVAT 336
Cdd:cd14882   149 MSGAIFWMYQLEKLRVSTTDGNQSNFHIFYYFYdfIEAQNRLKEYNLKAGRNYRYlriPPEVPPSKLKYRRDDPEGNVER 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  337 ----DTAIDILGFNNEEKMGIYKFTGAVLHHGNMKFKQKQREeqAEPDGTEEADKIGYLLGLNSADMLKALCYPRVKVGN 412
Cdd:cd14882   229 ykefEEILKDLDFNEEQLETVRKVLAAILNLGEIRFRQNGGY--AELENTEIASRVAELLRLDEKKFMWALTNYCLIKGG 306
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  413 EFVTKGQTVPQVYNSVSALSKSIYERMFLWMVVRINQMLDTKQQ---RNFFIGVLDIAGFEIFDFNSMEQLCINFTNEKL 489
Cdd:cd14882   307 SAERRKHTTEEARDARDVLASTLYSRLVDWIINRINMKMSFPRAvfgDKYSISIHDMFGFECFHRNRLEQLMVNTLNEQM 386
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  490 QQFFNHHMFVLEQEEYKKEGIVWEFIDFGMDLAACIELIEKPLGIFSILEEecmfpKATDTSFKNKLYDQHLGKCNAFQK 569
Cdd:cd14882   387 QYHYNQRIFISEMLEMEEEDIPTINLRFYDNKTAVDQLMTKPDGLFYIIDD-----ASRSCQDQNYIMDRIKEKHSQFVK 461
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  570 PkpakgkAEAH-FSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSS---VKLLATlyppvveetgggkkggKKKGGS 645
Cdd:cd14882   462 K------HSAHeFSVAHYTGRIIYDAREFADKNRDFVPPEMIETMRSSLdesVKLMFT----------------NSQVRN 519
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  646 MQTVSSQFR----ENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFK 721
Cdd:cd14882   520 MRTLAATFRatslELLKMLSIGANSGGTHFVRCIRSDLEYKPRGFHSEVVRQQMRALAVLDTAKARQKGFSYRIPFQEFL 599

                  ....*.
gi 288856329  722 QRYKVL 727
Cdd:cd14882   600 RRYQFL 605
MYSc_Myo44 cd14905
class XLIV myosin, motor domain; There is little known about the function of the myosin XLIV ...
107-768 1.08e-57

class XLIV myosin, motor domain; There is little known about the function of the myosin XLIV class. Members here include cellular slime mold Polysphondylium and soil-living amoeba Dictyostelium. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276870  Cd Length: 673  Bit Score: 213.42  E-value: 1.08e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  107 LKERYAAWMIYTYSGLFCATVNPYKWLP-VYDAEVVAAYRGKKRMeaPPHIFSVSDNAYQFMLTDRENQSVLITGESGAG 185
Cdd:cd14905     7 IQARYKKEIIYTYIGPILVSVNPLRYLPfLHSQELVRNYNQRRGL--PPHLFALAAKAISDMQDFRRDQLIFIGGESGSG 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  186 KTVNTKRVIQYFATVAVQGPEkkkeqasgkmqgSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTSGKLASA 265
Cdd:cd14905    85 KSENTKIIIQYLLTTDLSRSK------------YLRDYILESGIILESFGHASTDSNHNSSRWGKYFEMFYSLYGEIQGA 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  266 DIETYLLEKSRVTFQLPDERGYHIFYQMMTN-HKPELIEMTLITTNPYDFpMCSQGQITVASIDDKEELVATDTAIDILG 344
Cdd:cd14905   153 KLYSYFLDENRVTYQNKGERNFHIFYQFLKGiTDEEKAAYQLGDINSYHY-LNQGGSISVESIDDNRVFDRLKMSFVFFD 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  345 FNNEEKMGIYKFTGAVLHHGNMKFKQKQREEQAEPDGTEEAdkIGYLLGLNSADMLKALCYPRVKVGNEFVtkgqtvpqv 424
Cdd:cd14905   232 FPSEKIDLIFKTLSFIIILGNVTFFQKNGKTEVKDRTLIES--LSHNITFDSTKLENILISDRSMPVNEAV--------- 300
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  425 yNSVSALSKSIYERMFLWMVVRINQMLDTKQQRNfFIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFNHHMFVLEQEE 504
Cdd:cd14905   301 -ENRDSLARSLYSALFHWIIDFLNSKLKPTQYSH-TLGILDLFGQESSQLNGYEQFSINFLEERLQQIYLQTVLKQEQRE 378
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  505 YKKEGIVWEFIDFGMDLAACIELIEKplgIFSILEEECMFPKATDTSFKNKLYDqHLGKCNAFQKpKPAKgkaeahFSLV 584
Cdd:cd14905   379 YQTERIPWMTPISFKDNEESVEMMEK---IINLLDQESKNINSSDQIFLEKLQN-FLSRHHLFGK-KPNK------FGIE 447
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  585 HYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLAT------LYPPVVEETGGGKKGGKKKGGSMQTVS------SQ 652
Cdd:cd14905   448 HYFGQFYYDVRGFIIKNRDEILQRTNVLHKNSITKYLFSrdgvfnINATVAELNQMFDAKNTAKKSPLSIVKvllscgSN 527
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  653 FRENL-----------------------GKLMTNLRSTHP---------HFVRCLIPNESKTPGLMENFLVIHQLRCNGV 700
Cdd:cd14905   528 NPNNVnnpnnnsgggggggnsgggsgsgGSTYTTYSSTNKainnsncdfHFIRCIKPNSKKTHLTFDVKSVNEQIKSLCL 607
                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 288856329  701 LEGIRICRKGFPSRILYADFKQRYKVlnasvipegqFIDNKKASEKLLGSI---DVNHDE-----YRFGHTKVFFK 768
Cdd:cd14905   608 LETTRIQRFGYTIHYNNKIFFDRFSF----------FFQNQRNFQNLFEKLkenDINIDSilpppIQVGNTKIFLR 673
Motor_domain cd01363
Myosin and Kinesin motor domain; Myosin and Kinesin motor domain. These ATPases belong to the ...
123-254 1.12e-57

Myosin and Kinesin motor domain; Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes. Some of the names do not match with what is given in the sequence list. This is because they are based on the current nomenclature by Kollmar/Sebe-Pedros.


Pssm-ID: 276814 [Multi-domain]  Cd Length: 170  Bit Score: 197.18  E-value: 1.12e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  123 FCATVNPYKWLPVY-DAEVVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLITGESGAGKTVNTKRVIQYFATVA 201
Cdd:cd01363     1 VLVRVNPFKELPIYrDSKIIVFYRGFRRSESQPHVFAIADPAYQSMLDGYNNQSIFAYGESGAGKTETMKGVIPYLASVA 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 288856329  202 VQGPEKKKEQAS---GKMQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRI 254
Cdd:cd01363    81 FNGINKGETEGWvylTEITVTLEDQILQANPILEAFGNAKTTRNENSSRFGKFIEI 136
MYSc_Myo24B cd14938
class XXIV B myosin, motor domain; These myosins have a 1-2 IQ motifs in their neck and a ...
101-766 5.05e-47

class XXIV B myosin, motor domain; These myosins have a 1-2 IQ motifs in their neck and a coiled-coil region in their C-terminal tail. The functions of these myosins remain elusive. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276898 [Multi-domain]  Cd Length: 713  Bit Score: 181.96  E-value: 5.05e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  101 PSVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRME-APPHIFSVSDNAYQFMLTDRENQSVLIT 179
Cdd:cd14938     1 PSVLYHLKERFKNNKFYTKMGPLLIFINPKINNNINNEETIEKYKCIDCIEdLSLNEYHVVHNALKNLNELKRNQSIIIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  180 GESGAGKTVNTKRVIQYFA-----------TVAVQGPEKKKEQASGKMQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRF 248
Cdd:cd14938    81 GESGSGKSEIAKNIINFIAyqvkgsrrlptNLNDQEEDNIHNEENTDYQFNMSEMLKHVNVVMEAFGNAKTVKNNNSSRF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  249 GKFIRIHFGTSgKLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPELIEMTLItTNPYDFPMCSQGQITVASID 328
Cdd:cd14938   161 SKFCTIHIENE-EIKSFHIKKFLLDKERLINRKANENSFNIFYYIINGSSDKFKKMYFL-KNIENYSMLNNEKGFEKFSD 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  329 DKEELVATDTAIDILGFNNEEKMGIYKFTGAVLHHGN-------------MKFKQKQRE----------EQAEPDGTEEA 385
Cdd:cd14938   239 YSGKILELLKSLNYIFDDDKEIDFIFSVLSALLLLGNteivkafrkksllMGKNQCGQNinyetilselENSEDIGLDEN 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  386 DKIGYL----LGLNSADMLKALCYPRVkVGNEFVTKGQTVPQVYNSVSALSKSIYERMFLWMVVRINQMLDTKQQRNFF- 460
Cdd:cd14938   319 VKNLLLacklLSFDIETFVKYFTTNYI-FNDSILIKVHNETKIQKKLENFIKTCYEELFNWIIYKINEKCTQLQNININt 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  461 --IGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIVWEFIDFGMDLAACIELIEKPL--GIFS 536
Cdd:cd14938   398 nyINVLDMAYFENSKDNSLEQLLINTTNEEIIKIKNDCLYKKRVLSYNEDGIFCEYNSENIDNEPLYNLLVGPTegSLFS 477
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  537 ILEEECMfPKATDTSFKNKLYDQHLGKCNAFQKPKPAKGKAEAhFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKS 616
Cdd:cd14938   478 LLENVST-KTIFDKSNLHSSIIRKFSRNSKYIKKDDITGNKKT-FVITHSCGDIIYNAENFVEKNIDILTNRFIDMVKQS 555
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  617 SVKLLATL--------YPPVVEETGGGKKG------GKKKGGSMQTVSSQFRENLGKLMTNLRSTHPHFVRCLIPNESK- 681
Cdd:cd14938   556 ENEYMRQFcmfynydnSGNIVEEKRRYSIQsalklfKRRYDTKNQMAVSLLRNNLTELEKLQETTFCHFIVCMKPNESKr 635
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  682 -TPGLMENfLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNAsvipegqfiDNKKASEKLLGSIDVNHDEYRF 760
Cdd:cd14938   636 eLCSFDAN-IVLRQVRNFSIVEASQLKVGYYPHKFTLNEFLSIFDIKNE---------DLKEKVEALIKSYQISNYEWMI 705

                  ....*.
gi 288856329  761 GHTKVF 766
Cdd:cd14938   706 GNNMIF 711
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
1146-1928 1.13e-33

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 142.50  E-value: 1.13e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1146 EEISERLEEAGGATaaqiemnkkreaefqKLRRDLEESTLQHEATAAALrKKQADSVAELGEQIDNLQRVKQKLEK---- 1221
Cdd:TIGR02168  155 EERRAIFEEAAGIS---------------KYKERRKETERKLERTRENL-DRLEDILNELERQLKSLERQAEKAERykel 218
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1222 -------EKSEYKMEIDDLSSNMEAVAKAKANLEKMCRTLEDQLSEIKSKNDENLRQINDLSAQRARLQTENGEFGRQLE 1294
Cdd:TIGR02168  219 kaelrelELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEIS 298
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1295 EKEALV-------SQLTRGKQAFTQQIEELKRQIEEEVKAKNALAHAVQSARHDCDLLREQFEEEQEAKAELQRGMSKAN 1367
Cdd:TIGR02168  299 RLEQQKqilrerlANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELE 378
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1368 SEVAQWRTKYEtdaiqrteELEESKKKLAQRLQEAEEQIEavnskcaSLEKTKQRLQGEVEDLMIDVERAN--ALAANLD 1445
Cdd:TIGR02168  379 EQLETLRSKVA--------QLELQIASLNNEIERLEARLE-------RLEDRRERLQQEIEELLKKLEEAElkELQAELE 443
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1446 KKqrnfDKVLAEWKQKYEEGQAELEGAQKEARSLSTELFKMKNSYEET---LDQLETLKRENKNLQQEI-------SDLT 1515
Cdd:TIGR02168  444 EL----EEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLqarLDSLERLQENLEGFSEGVkallknqSGLS 519
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1516 EQLGETGKSIHELEKSKKAVETEKAEIQTAL-----EEAEGTLEH-EESKILRVQ-LELNQVKseiDRKLAEKDEEIEQI 1588
Cdd:TIGR02168  520 GILGVLSELISVDEGYEAAIEAALGGRLQAVvvenlNAAKKAIAFlKQNELGRVTfLPLDSIK---GTEIQGNDREILKN 596
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1589 KRNSQRITDSMQSTldsevrsrndALRIKKKMEGDLNEMEI--QLSHANRQAAEAQKQLRNVQaqlKDAQLHLDDAVRGQ 1666
Cdd:TIGR02168  597 IEGFLGVAKDLVKF----------DPKLRKALSYLLGGVLVvdDLDNALELAKKLRPGYRIVT---LDGDLVRPGGVITG 663
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1667 EDMKEQVAMVERRNtlmqsEIEELRAALEQTERGRKVAEQELVDASERVGLLHSQNTSLLNTKKKLEADLVQIQSEVEDT 1746
Cdd:TIGR02168  664 GSAKTNSSILERRR-----EIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARL 738
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1747 VQEARNAEDKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEVTVKDLQHRLDEAENlamkggkkQLQKLESRVRELES 1826
Cdd:TIGR02168  739 EAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKE--------ELKALREALDELRA 810
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1827 EVEAEQRRGADAVKGVRKYERRVKELTYQTEEDKKNVNRLQDLVDKLQLKVKAYKRQSEEAEEQANSHLSKLRKVQHELE 1906
Cdd:TIGR02168  811 ELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALA 890
                          810       820
                   ....*....|....*....|..
gi 288856329  1907 EAEERADIAESQVNKLRAKSRD 1928
Cdd:TIGR02168  891 LLRSELEELSEELRELESKRSE 912
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
914-1796 1.69e-32

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 138.65  E-value: 1.69e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   914 KIQLEAKLKETTERLEDEEEINAELTAKKRKLEDECS------ELKKDIDDLELTLAKVEKEKHAtenkvknltEEMAAQ 987
Cdd:TIGR02168  174 RKETERKLERTRENLDRLEDILNELERQLKSLERQAEkaerykELKAELRELELALLVLRLEELR---------EELEEL 244
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   988 DESIGKLTKEKKALQEAhqqtlddLQAEEDKVNTLTKSKTKLEQQVDDLEGSLEqekklrmDLERAKRKLEGDLKLAQES 1067
Cdd:TIGR02168  245 QEELKEAEEELEELTAE-------LQELEEKLEELRLEVSELEEEIEELQKELY-------ALANEISRLEQQKQILRER 310
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1068 IMDLENDKQQSEEKLKkkdfetsQLLSKIEDEQSLGAQLQKKIKELQArieeleeeieaeraarakvekqradlsrELEE 1147
Cdd:TIGR02168  311 LANLERQLEELEAQLE-------ELESKLDELAEELAELEEKLEELKE----------------------------ELES 355
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1148 ISERLEEAGGATAAQIEMNKKREAEFQKLRRDLEESTLQhEATAAALRKKQADSVAELGEQIDNLQRVKQKLEKEKSEYK 1227
Cdd:TIGR02168  356 LEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQ-IASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAE 434
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1228 MEidDLSSNMEAVAKAKANLEKMCRTLEDQLSEIKSKNDENLRQINDLSAQRARLQTENGEFGRQLEEKEAL---VSQLT 1304
Cdd:TIGR02168  435 LK--ELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFsegVKALL 512
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1305 RGKQAFTQQIEELKRQIEEEVKAKNALAHAVQSARHDcdLLREQFEEEQEAKAELqrgmskANSEVAQWrTKYETDAIqr 1384
Cdd:TIGR02168  513 KNQSGLSGILGVLSELISVDEGYEAAIEAALGGRLQA--VVVENLNAAKKAIAFL------KQNELGRV-TFLPLDSI-- 581
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1385 teeleeSKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQGEVEDLM------IDVERANALAANLDKKQRNF------- 1451
Cdd:TIGR02168  582 ------KGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLggvlvvDDLDNALELAKKLRPGYRIVtldgdlv 655
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1452 ---------------------------DKVLAEWKQKYEEGQAELEGAQKEARSLSTELFKMKNSYEETLDQLETLKREN 1504
Cdd:TIGR02168  656 rpggvitggsaktnssilerrreieelEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDL 735
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1505 KNLQQEISDLTEQLGETGKSIHELEKSKKAVETEKAEIQTALEEAEGTLEHEESKILRVQLELNQVKSEIDRKLAEKDEE 1584
Cdd:TIGR02168  736 ARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLL 815
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1585 IEQIKRNSQRItDSMQSTLDSEVRSRNDALRIKKKMEGDLNEMEIQLSHANRQAAEAQKQLRNVQAQLKDAQLHLDDAVR 1664
Cdd:TIGR02168  816 NEEAANLRERL-ESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRS 894
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1665 GQEDMKEQVAMVERRNTLMQSEIEELRAALEQTERGRKVAEQELvdaservgllhSQNTSLLNTKKKLEADLV-QIQSEV 1743
Cdd:TIGR02168  895 ELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRI-----------DNLQERLSEEYSLTLEEAeALENKI 963
                          890       900       910       920       930
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 288856329  1744 EDTVQEARNAEDKAKKAITD------AAMmaEELKKEQDTSAHLERMKKNLEVTVKDLQ 1796
Cdd:TIGR02168  964 EDDEEEARRRLKRLENKIKElgpvnlAAI--EEYEELKERYDFLTAQKEDLTEAKETLE 1020
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
910-1750 1.54e-31

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 135.57  E-value: 1.54e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   910 LIKSKIQLEAKLKETTERLEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAAQDE 989
Cdd:TIGR02168  230 LVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRE 309
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   990 SIGKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKSKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIM 1069
Cdd:TIGR02168  310 RLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVA 389
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1070 DLENDKQQSEEKLkkkdfetSQLLSKIEDEQSLGAQLQKKIKELQARieeleeeieaeraaraKVEKQRADLSRELEEIS 1149
Cdd:TIGR02168  390 QLELQIASLNNEI-------ERLEARLERLEDRRERLQQEIEELLKK----------------LEEAELKELQAELEELE 446
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1150 ERLEEAGGATAAQIEMNKKREAEFQKLRRDLEESTLQHEATAAALrkkqaDSVAELGEQIDNLQRVKQKLEKEKSEYKME 1229
Cdd:TIGR02168  447 EELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARL-----DSLERLQENLEGFSEGVKALLKNQSGLSGI 521
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1230 IDDLSSNMEAVAKAKANLEKmcrTLEDQLSEIKSKNDENLRQINDLSAQ----RARLQTENGEFGRQLEEKEALVSQLTR 1305
Cdd:TIGR02168  522 LGVLSELISVDEGYEAAIEA---ALGGRLQAVVVENLNAAKKAIAFLKQnelgRVTFLPLDSIKGTEIQGNDREILKNIE 598
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1306 GKQAFTQQIEELKRQIEEEVKA-----------KNALAHAVQSARH------DCDLLReqfeeeqeAKAELQRGMSKANS 1368
Cdd:TIGR02168  599 GFLGVAKDLVKFDPKLRKALSYllggvlvvddlDNALELAKKLRPGyrivtlDGDLVR--------PGGVITGGSAKTNS 670
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1369 EVAQWRTKYEtDAIQRTEELEESKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQGEVEDLMIDVERANALAANLDKKQ 1448
Cdd:TIGR02168  671 SILERRREIE-ELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERI 749
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1449 RNFDKVLAEWKQKYEEGQAELEGAQKEARSLSTELFKMKNSYEETLDQLETLKRENKNLQQEISDLTEQLGETGKSIHEL 1528
Cdd:TIGR02168  750 AQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESL 829
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1529 EKSKKAVETEKAEIQTALEEAEGTLEHEESKILRVQLELNQVKSEIDRKLAEKDEEIEQIKrnsqritdSMQSTLDSEVR 1608
Cdd:TIGR02168  830 ERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALA--------LLRSELEELSE 901
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1609 SRNDALRIKKKMEGDLNEMEIQLSHANRQAAEAQKQLRNVQAQL-KDAQLHLDDAVRGQEDMKEQVAMVERRNTLMQSEI 1687
Cdd:TIGR02168  902 ELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLsEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKI 981
                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 288856329  1688 EEL-RAALEqtergrkvAEQELVDASERVGLLHSQNTSLLNTKKKLEADLVQIQSEVEDTVQEA 1750
Cdd:TIGR02168  982 KELgPVNLA--------AIEEYEELKERYDFLTAQKEDLTEAKETLEEAIEEIDREARERFKDT 1037
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
1134-1911 4.47e-28

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 124.02  E-value: 4.47e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1134 VEKQRAdlSRELEEISERLEEAggataaQIEMNKKREaEFQKLRRDLEEStlqhEATAAALRKKQADSVAELGEQIDNLQ 1213
Cdd:TIGR02169  170 RKKEKA--LEELEEVEENIERL------DLIIDEKRQ-QLERLRREREKA----ERYQALLKEKREYEGYELLKEKEALE 236
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1214 RVKQKLEKEKSEYKMEIDDLSSNMEAVAKAKANLEKMCRTLEDQLSEIKSknDENLR---QINDLSAQRARLQTENGEFG 1290
Cdd:TIGR02169  237 RQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGE--EEQLRvkeKIGELEAEIASLERSIAEKE 314
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1291 RQLEEKEALVSQLTRGKQAFTQQIEELKRQIEEEVKAKNALAHAVQSARHDCDLLREQFEEEQEAKAELQRgmskansEV 1370
Cdd:TIGR02169  315 RELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRD-------EL 387
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1371 AQWRTKYEtDAIQRTEELEESKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQGEVEDLMIDVERAnalaanlDKKQRN 1450
Cdd:TIGR02169  388 KDYREKLE-KLKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQ-------EWKLEQ 459
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1451 FDKVLAEWKQKYEEGQAELEGAQKEARSLSTELfkmknsyeetlDQLETLKRENKNLQQEISDLTEQLGETGKSIHELEK 1530
Cdd:TIGR02169  460 LAADLSKYEQELYDLKEEYDRVEKELSKLQREL-----------AEAEAQARASEERVRGGRAVEEVLKASIQGVHGTVA 528
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1531 SKKAVeteKAEIQTALEEAEG------TLEHE-----------ESKILRVQ-LELNQVKSE--------------IDRKL 1578
Cdd:TIGR02169  529 QLGSV---GERYATAIEVAAGnrlnnvVVEDDavakeaiellkRRKAGRATfLPLNKMRDErrdlsilsedgvigFAVDL 605
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1579 AEKDEEIEQIKRNSQRITDSMQS--------------TLDSEV-----------RSRNDALRIKKKMEGDLNEMEIQLSH 1633
Cdd:TIGR02169  606 VEFDPKYEPAFKYVFGDTLVVEDieaarrlmgkyrmvTLEGELfeksgamtggsRAPRGGILFSRSEPAELQRLRERLEG 685
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1634 ANRQAAEAQKQLRNVQAQLKDAQLHLDDAVRGQEDMKEQVAMVERRNTLMQSEIEELRAALEQTERGRKVAEQELVDASE 1713
Cdd:TIGR02169  686 LKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEA 765
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1714 RVGLLHSQNTSLLNTKKKLEADLVQiqSEVEDTVQEARNAEDKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEVTVK 1793
Cdd:TIGR02169  766 RIEELEEDLHKLEEALNDLEARLSH--SRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRI 843
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1794 DLQHRL----DEAENLAMKGGKK--QLQKLESRVRELESEVEAEQRRGADAVKGVRKYERRVKELTYQTEEDKKNVNRLQ 1867
Cdd:TIGR02169  844 DLKEQIksieKEIENLNGKKEELeeELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELK 923
                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....
gi 288856329  1868 DLVDKLQLKVKAYKRQSEEAEEQANSHLSkLRKVQHELEEAEER 1911
Cdd:TIGR02169  924 AKLEALEEELSEIEDPKGEDEEIPEEELS-LEDVQAELQRVEEE 966
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
845-1595 3.87e-26

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 117.85  E-value: 3.87e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   845 AETEKELATMKEDFVKCKEDLAKAEAKKKELEEKMVALLQEKNDLQLAVASESENLSDAEERCEGLIKSKIQLEAKLKET 924
Cdd:TIGR02168  242 EELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEEL 321
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   925 TERLEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAAQDESIgKLTKEKKALQEA 1004
Cdd:TIGR02168  322 EAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKV-AQLELQIASLNN 400
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1005 HQQTLddlqaeEDKVNTLTKSKTKLEQQVDDLEGSLEqekklrmdlERAKRKLEGDLKLAQESIMDLENDKQQSEEKLKK 1084
Cdd:TIGR02168  401 EIERL------EARLERLEDRRERLQQEIEELLKKLE---------EAELKELQAELEELEEELEELQEELERLEEALEE 465
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1085 KDFETSQLLSKIEDEQSLGAQLQKKIKELQARIEELEEEIEAERAARAKVEKQRADLSRELEEISER------LEEAGGA 1158
Cdd:TIGR02168  466 LREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISVDegyeaaIEAALGG 545
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1159 TAAQIEMNKKREA--EFQKLRRDLEESTLQHEATAAALRKKQADSvAELGEQIDNLQRVKQKLEKEKSEYKMEIDDLSSN 1236
Cdd:TIGR02168  546 RLQAVVVENLNAAkkAIAFLKQNELGRVTFLPLDSIKGTEIQGND-REILKNIEGFLGVAKDLVKFDPKLRKALSYLLGG 624
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1237 MEAVAKAKANLEKmcRTLEDQLSEIKSKNDENLRQinDLSAQRARLQTENGEFGRQLEEKEAlvsqltrgkqafTQQIEE 1316
Cdd:TIGR02168  625 VLVVDDLDNALEL--AKKLRPGYRIVTLDGDLVRP--GGVITGGSAKTNSSILERRREIEEL------------EEKIEE 688
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1317 LKRQIEEEVKAKNALAHAVQSARHDCDLLREQFEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTeELEESKKKLA 1396
Cdd:TIGR02168  689 LEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELT-ELEAEIEELE 767
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1397 QRLQEAEEQIEAVNSKCASLEKTKQRLQGEVEDL--MIDVERA-----NALAANLDKKQRNFDKVLAEWKQKYEEGQAEL 1469
Cdd:TIGR02168  768 ERLEEAEEELAEAEAEIEELEAQIEQLKEELKALreALDELRAeltllNEEAANLRERLESLERRIAATERRLEDLEEQI 847
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1470 EGAQKEARSLSTELFKMKNSYEETLDQLETLKRENKNLQQEISDLTEQLGETGKSIHELEKSKKAVETEKAEIQTALEEA 1549
Cdd:TIGR02168  848 EELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQL 927
                          730       740       750       760       770
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 288856329  1550 EGTLEHEESKILRVQLELN-----------QVKSEIDRKLAEKDEEIEQIKRNSQRI 1595
Cdd:TIGR02168  928 ELRLEGLEVRIDNLQERLSeeysltleeaeALENKIEDDEEEARRRLKRLENKIKEL 984
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
919-1805 3.04e-24

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 111.70  E-value: 3.04e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   919 AKLKETTERLEDEEEINAELTAKKRKLEDECSELKKdIDDLELTLAKVE-----KEKHATENKVKNLTEEMAAQDESIGK 993
Cdd:TIGR02169  177 EELEEVEENIERLDLIIDEKRQQLERLRREREKAER-YQALLKEKREYEgyellKEKEALERQKEAIERQLASLEEELEK 255
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   994 LTKEKKALQEAHQQTLDDLQAEEDKVNTLTKSKT-KLEQQVDDLEGSLEQekklrmdlerakrkLEGDLKLAQESIMDLE 1072
Cdd:TIGR02169  256 LTEEISELEKRLEEIEQLLEELNKKIKDLGEEEQlRVKEKIGELEAEIAS--------------LERSIAEKERELEDAE 321
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1073 NDKQQSEEKLKKKDFETSQLLSKIEDEQSLGAQLQKKIKELQARIEELEEEIEAERAARAKVEKQRADLSRELEEISERL 1152
Cdd:TIGR02169  322 ERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREI 401
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1153 EEAGGATAAQIEMNKKREAEFQKLRRDLEESTLQHEATAAALRKKQadsvAELGEQIDNLQRVKQKLEKEKSEYKmeidd 1232
Cdd:TIGR02169  402 NELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKA----LEIKKQEWKLEQLAADLSKYEQELY----- 472
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1233 lssnmeavakakaNLEKMCRTLEDQLSEIKskndenlRQINDLSAQRARLQTENGEFGRQLEEKEA-------LVSQLTR 1305
Cdd:TIGR02169  473 -------------DLKEEYDRVEKELSKLQ-------RELAEAEAQARASEERVRGGRAVEEVLKAsiqgvhgTVAQLGS 532
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1306 GKQAFTQQIEELKRQ------IEEEVKAKNA--LAHAVQSARHDCDLLREQFEEEQEAKAELQRGMSKANSEVAQWRTKY 1377
Cdd:TIGR02169  533 VGERYATAIEVAAGNrlnnvvVEDDAVAKEAieLLKRRKAGRATFLPLNKMRDERRDLSILSEDGVIGFAVDLVEFDPKY 612
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1378 ETD---AIQRT---EELEESKK--------KLAQRLQEAEEQIEAVNSKCASLEKTKQRLQGEVEDLMIDVERANALAAN 1443
Cdd:TIGR02169  613 EPAfkyVFGDTlvvEDIEAARRlmgkyrmvTLEGELFEKSGAMTGGSRAPRGGILFSRSEPAELQRLRERLEGLKRELSS 692
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1444 LDKKQRNFDKVLAEWKQKYEEGQAELEGAQKEArslstelfkmknsyEETLDQLETLKRENKNLQQEISDLTEQLGETGK 1523
Cdd:TIGR02169  693 LQSELRRIENRLDELSQELSDASRKIGEIEKEI--------------EQLEQEEEKLKERLEELEEDLSSLEQEIENVKS 758
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1524 SIHELEKSKKAVETEKAEIQTALEEAEGTLEHEESKILRVQL-ELNQVKSEIDRKLAEKDEEIEQIKRNSQRITDSMQst 1602
Cdd:TIGR02169  759 ELKELEARIEELEEDLHKLEEALNDLEARLSHSRIPEIQAELsKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQ-- 836
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1603 ldsEVRSRNDALRIKKKMEGD-LNEMEIQLSHANRQAAEAQKQLRNVQAQLKDaqlhlddavrgqedmkeqvamverrnt 1681
Cdd:TIGR02169  837 ---ELQEQRIDLKEQIKSIEKeIENLNGKKEELEEELEELEAALRDLESRLGD--------------------------- 886
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1682 lMQSEIEELRAALEQTERGRKVAEQELVDASERVGLLHSQNTSLLNTKKKLEADLVQIQSEVE-----DTVQEARNAEDK 1756
Cdd:TIGR02169  887 -LKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEEIPEeelslEDVQAELQRVEE 965
                          890       900       910       920       930
                   ....*....|....*....|....*....|....*....|....*....|
gi 288856329  1757 AKKAITDAAMMA-EELKKEQDTSAHLERMKKNLEVTVKDLQHRLDEAENL 1805
Cdd:TIGR02169  966 EIRALEPVNMLAiQEYEEVLKRLDELKEKRAKLEEERKAILERIEEYEKK 1015
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
1141-1733 8.38e-24

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 110.03  E-value: 8.38e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1141 LSRELEEISERLEEAGGATAAQIEMNKKREAEFQKLRRDLEESTLQHEATAAALRKKQADsVAELGEQIDNLQRVKQKLE 1220
Cdd:COG1196   230 LLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAE-EYELLAELARLEQDIARLE 308
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1221 KEKSEYKMEIDDLSSNMEAVAKAKANLEKMCRTLEDQLSEIKSKNDENLRQINDLSAQRARLQTENGEFGRQLEEKEALV 1300
Cdd:COG1196   309 ERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEEL 388
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1301 SQLTRGKQAFTQQIEELKRQIEEEVKAKNALAHAVQSarhdcdlLREQFEEEQEAKAELQRGMSKANSEVAQWRTKYETD 1380
Cdd:COG1196   389 LEALRAAAELAAQLEELEEAEEALLERLERLEEELEE-------LEEALAELEEEEEEEEEALEEAAEEEAELEEEEEAL 461
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1381 AIQRTEELEESKKKLAQRLQEAEEQIEAvnskcASLEKTKQRLQGEVEDLMIDVERANALAANLDKKQRnfDKVLAEWKQ 1460
Cdd:COG1196   462 LELLAELLEEAALLEAALAELLEELAEA-----AARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGA--VAVLIGVEA 534
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1461 KYEEGQAELEGAQKEARSLST--------ELFKMKNSYEETLDQLETLKREN--KNLQQEISDLTEQLGETGKSIHELEK 1530
Cdd:COG1196   535 AYEAALEAALAAALQNIVVEDdevaaaaiEYLKAAKAGRATFLPLDKIRARAalAAALARGAIGAAVDLVASDLREADAR 614
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1531 SKKAVETEKAEIQTALEEAEG-----TLEHEESKILRVQLELNQVKSEIDRKLAEKDEEIEQIKRNSQRITDSMQSTLDS 1605
Cdd:COG1196   615 YYVLGDTLLGRTLVAARLEAAlrravTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELE 694
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1606 EVRSRNDALRIKKKMEGDLNEMEIQLSHANRQAAEAQKQLRNVQAQLKDAQLHLDDAVRGQEDMKEQVAMVERRntlmqs 1685
Cdd:COG1196   695 LEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERE------ 768
                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|.
gi 288856329 1686 eIEELRAALEQTErgrKV---AEQELVDASERVGLLHSQNTSLLNTKKKLE 1733
Cdd:COG1196   769 -LERLEREIEALG---PVnllAIEEYEELEERYDFLSEQREDLEEARETLE 815
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
914-1514 1.76e-23

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 108.87  E-value: 1.76e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  914 KIQLEAKLKETTERLEDEEEINAELTAKKRKLEdecsELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAAQDESIGK 993
Cdd:COG1196   217 ELKEELKELEAELLLLKLRELEAELEELEAELE----ELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYE 292
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  994 LTKEKKALQEAHQQTLDDLQAEEDKVNTLTKSKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDLEN 1073
Cdd:COG1196   293 LLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEA 372
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1074 DKQQSEEKLKKKDFETSQLLSKIEDEQSLGAQLQKKIKELQARIEELEEEIEAERAARAKVEKQRADLSRELEEISERLE 1153
Cdd:COG1196   373 ELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEA 452
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1154 EAGGATAAQIEMNKKREAEFQKLRRDLEESTLQHEATAAALRKKQADSVAELGEQIDNLQRVKQKLEKEKSEYKMEIDDL 1233
Cdd:COG1196   453 ELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGV 532
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1234 SSNMEAVAKAKAN---LEKMCRTLEDQLSEIkskndENLRQINDLSAQRARLQTENGEFGRQLEEKEALVSQLTRGKQAF 1310
Cdd:COG1196   533 EAAYEAALEAALAaalQNIVVEDDEVAAAAI-----EYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASD 607
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1311 TQQIEELKRQIEEEVKAKNALAHAVQSARHdcdlLREQFEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEE 1390
Cdd:COG1196   608 LREADARYYVLGDTLLGRTLVAARLEAALR----RAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEE 683
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1391 SKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQGEVEDLMIDVERANALAANLDKKQRNFDKVLAEWKQKYEEGQAELE 1470
Cdd:COG1196   684 LAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLE 763
                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|.
gi 288856329 1471 GAQKEARSLSTELFKMKN-------SYEETLDQLETLKRENKNLQQEISDL 1514
Cdd:COG1196   764 ELERELERLEREIEALGPvnllaieEYEELEERYDFLSEQREDLEEARETL 814
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
841-1454 2.27e-23

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 108.49  E-value: 2.27e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  841 LLKSAETEKELATMKEDFVKCKEDLAKAEAKKKELEEKMVALLQEKNDLQLAVASESENLSDAEERCEGLIKSKIQLEAK 920
Cdd:COG1196   231 LLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEER 310
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  921 LKETTERLEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAAQDESIGKLTKEKKA 1000
Cdd:COG1196   311 RRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLE 390
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1001 LQEAHQQTLDDLQAEEDKVNTLTKSKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDLENDKQQSEE 1080
Cdd:COG1196   391 ALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLE 470
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1081 KLKKKDFETSQLLSKIEDEQSLGAQLQKKIKELQARIE--ELEEEIEAERAARAKVEKQRADLSRELEEISERLEEAGGA 1158
Cdd:COG1196   471 EAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEgvKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQN 550
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1159 TAAQIEMNKKREAEFQKLRRDLEESTLQHEATAAALRKKQADSVAELGEQIDnlqRVKQKLEKEKSEYKMEIDDLSSNME 1238
Cdd:COG1196   551 IVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVD---LVASDLREADARYYVLGDTLLGRTL 627
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1239 AVAKAKANLEKMCRTLEDQLSEIKSKNDENLRQINDLSAQRARLQtengefgrQLEEKEALVSQLTRGKQAFTQQIEELK 1318
Cdd:COG1196   628 VAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLA--------ALLEAEAELEELAERLAEEELELEEAL 699
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1319 RQIEEEVKAKNALAHAVQSARHDCDLLREQFEEEQEAKAELQRGMSKANSEVAqwrtKYETDAIQRTEELEESKKKLAQR 1398
Cdd:COG1196   700 LAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEA----LEELPEPPDLEELERELERLERE 775
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1399 LQ--------------EAEEQIEAVNSKCASLEKTKQRLQGEVEDlmIDVERANALAANLDKKQRNFDKV 1454
Cdd:COG1196   776 IEalgpvnllaieeyeELEERYDFLSEQREDLEEARETLEEAIEE--IDRETRERFLETFDAVNENFQEL 843
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
1218-1925 2.43e-23

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 108.49  E-value: 2.43e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1218 KLEKEKSEYKMEiddlssnmeavaKAKANLEKmcrtLEDQLSEIKskndenlRQINDLSAQRAR------LQTEngefgr 1291
Cdd:COG1196   171 KERKEEAERKLE------------ATEENLER----LEDILGELE-------RQLEPLERQAEKaeryreLKEE------ 221
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1292 qLEEKEALVSQLTRgkQAFTQQIEELKRQIEEEVKAKNALAHAVQSARHDCDLLREQFEEEQEAKAELQRGMSKANSEVA 1371
Cdd:COG1196   222 -LKELEAELLLLKL--RELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELA 298
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1372 QwrtkyetdAIQRTEELEESKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQGEVEDLMIDVERANALAANLDKKQRNF 1451
Cdd:COG1196   299 R--------LEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEA 370
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1452 DKVLAEWKQKYEEGQAELEGAQKEARSLSTELfkmknsyEETLDQLETLKRENKNLQQEISDLTEQLGETGKSIHELEKS 1531
Cdd:COG1196   371 EAELAEAEEELEELAEELLEALRAAAELAAQL-------EELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEA 443
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1532 KKAVETEKAEIQTALEEAEGTLEHEESKILRVQLELNQVKSEIDRKLAEKDEEIEQIKRNSQRITDSMQSTLDSEVRSRN 1611
Cdd:COG1196   444 LEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLA 523
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1612 DALRIkkkmegdlnemEIQLSHANRQAAEAQKQLRNVQAQLKDAQlhldDAVRGQEDMKEQVAmvERRNTLMQSEIEELR 1691
Cdd:COG1196   524 GAVAV-----------LIGVEAAYEAALEAALAAALQNIVVEDDE----VAAAAIEYLKAAKA--GRATFLPLDKIRARA 586
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1692 AALEQTERGRKVAEQELVDAservgllhsqntsllntkkkLEADLVQIQSEVEDTVQEARNAEDKAKKAITDAAMMAEEL 1771
Cdd:COG1196   587 ALAAALARGAIGAAVDLVAS--------------------DLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRL 646
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1772 KKEQDTSAHLERMKKNLEVTVKDLQHRLDEAEnlamkggkKQLQKLESRVRELESEVEAEQRRGADAvkgvrkyERRVKE 1851
Cdd:COG1196   647 REVTLEGEGGSAGGSLTGGSRRELLAALLEAE--------AELEELAERLAEEELELEEALLAEEEE-------ERELAE 711
                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 288856329 1852 LTYQTEEDKKNVNRLQDLVDKLQLKVKAYKRQSEEAEEQAnshlsklrkvQHELEEAEERADIAESQVNKLRAK 1925
Cdd:COG1196   712 AEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEE----------ALEELPEPPDLEELERELERLERE 775
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
881-1592 3.17e-23

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 108.23  E-value: 3.17e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   881 ALLQEKNDLQLAVASESENLSDAEERCEGLIKSKIQLEAKLKETTERLED--EEEINA------ELTAKKRKLEDECSEL 952
Cdd:TIGR02169  234 ALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDlgEEEQLRvkekigELEAEIASLERSIAEK 313
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   953 KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAAQDESIGKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKSKTKLEQQ 1032
Cdd:TIGR02169  314 ERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREK 393
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1033 VDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDLENDKQQSEEKLKKKDFETSQLLSKIEDEQSLGAQLQKKIKE 1112
Cdd:TIGR02169  394 LEKLKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYD 473
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1113 LQARIEELEEEIEAERAARAKVEKQR----------------------------ADLSRELEEISERLEEAGG------- 1157
Cdd:TIGR02169  474 LKEEYDRVEKELSKLQRELAEAEAQAraseervrggraveevlkasiqgvhgtvAQLGSVGERYATAIEVAAGnrlnnvv 553
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1158 ----ATAAQ-IEMNKKREA------EFQKLRRDLEESTLQHEATAAALrkkqADSVAELGEQIDNLQR-------VKQKL 1219
Cdd:TIGR02169  554 veddAVAKEaIELLKRRKAgratflPLNKMRDERRDLSILSEDGVIGF----AVDLVEFDPKYEPAFKyvfgdtlVVEDI 629
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1220 EKEKS---EYKM-----EIDDLSSNMEAVAKAKANLEKMCRTLEDQLSEIKSKNDENLRQINDLSAQRARLQTENGEF-- 1289
Cdd:TIGR02169  630 EAARRlmgKYRMvtlegELFEKSGAMTGGSRAPRGGILFSRSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELsq 709
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1290 -----GRQLEEKEALVSQLTRGKQAFTQQIEELKRQIEEEVKAKNALAHAVQSARHDCDLLREQFEEEQEAKAELQRgmS 1364
Cdd:TIGR02169  710 elsdaSRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEA--R 787
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1365 KANSEVAQWRTKYetdaiqrtEELEESKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQGEVEDLMIDVERANALAANL 1444
Cdd:TIGR02169  788 LSHSRIPEIQAEL--------SKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENL 859
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1445 DKKQRNFDKVLAEWKQKYEEGQAELEGAQKEARSLSTELFKMKNSYEETLDQLETLKRENKNLQQEISDLTEQLGETGKS 1524
Cdd:TIGR02169  860 NGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDP 939
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1525 IHELEKSKKAV---ETEKAEIQtALEEAEGTL---------EHEESKILRVQLELNQVKSEIDRK-LAEKDEEIEQIKRN 1591
Cdd:TIGR02169  940 KGEDEEIPEEElslEDVQAELQ-RVEEEIRALepvnmlaiqEYEEVLKRLDELKEKRAKLEEERKaILERIEEYEKKKRE 1018

                   .
gi 288856329  1592 S 1592
Cdd:TIGR02169 1019 V 1019
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
911-1590 3.46e-22

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 104.76  E-value: 3.46e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   911 IKSKIQLEAKLKETTERLEDEEEINAELTAKKRKLEDecseLKKDIDDLELTLAKVEKEKHATENKVKNLTE-EMAAQDE 989
Cdd:TIGR02169  219 EKREYEGYELLKEKEALERQKEAIERQLASLEEELEK----LTEEISELEKRLEEIEQLLEELNKKIKDLGEeEQLRVKE 294
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   990 SIGKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKSKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIM 1069
Cdd:TIGR02169  295 KIGELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELE 374
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1070 DLENDKQQSEEKLKKKDFETSQLLSKIEDEQSLGAQLQKKIKELQARIEELEEEIEAERAARAKVEKQRADLSRELEEIS 1149
Cdd:TIGR02169  375 EVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQE 454
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1150 ERLEEAGGATAAQIEMNKKREAEFQKLRRDLEESTLQH---EATAAALRKKQADSVA---ELGEQIDNLQRVKQKLEKEK 1223
Cdd:TIGR02169  455 WKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELaeaEAQARASEERVRGGRAveeVLKASIQGVHGTVAQLGSVG 534
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1224 SEYKMEIDDLSSNM--------EAVAKAKANL---EKMCRTLEDQLSEIKSKNdenlrqiNDLSAQRarlqtENGEFGRQ 1292
Cdd:TIGR02169  535 ERYATAIEVAAGNRlnnvvvedDAVAKEAIELlkrRKAGRATFLPLNKMRDER-------RDLSILS-----EDGVIGFA 602
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1293 L-----EEKEALVSQLTRGKQAFTQQIEELKRQ--------IEEEVKAK--------NALAHAVQSARHDCDLLREQFEE 1351
Cdd:TIGR02169  603 VdlvefDPKYEPAFKYVFGDTLVVEDIEAARRLmgkyrmvtLEGELFEKsgamtggsRAPRGGILFSRSEPAELQRLRER 682
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1352 EQEAKAELQRGMSKAN---SEVAQWRTKYEtDAIQRTEELEESKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQGEVE 1428
Cdd:TIGR02169  683 LEGLKRELSSLQSELRrieNRLDELSQELS-DASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELK 761
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1429 DLMIDVERANALAANLDKKQRNFDKVLAEwkQKYEEGQAELEGAQKEARSLSTELFKMKNSYEETLDQLETLKRENKNLQ 1508
Cdd:TIGR02169  762 ELEARIEELEEDLHKLEEALNDLEARLSH--SRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQ 839
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1509 QEISDLTEQLGETGKSIHELEKSKKAVETEKAEIQTALEEAEGTLEHEESKILRVQLELNQVKSEIDRKLAEKDEEIEQI 1588
Cdd:TIGR02169  840 EQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRL 919

                   ..
gi 288856329  1589 KR 1590
Cdd:TIGR02169  920 SE 921
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
1195-1925 9.96e-22

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 103.22  E-value: 9.96e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1195 RKKQADSVAELGEQIDNLQRVKQKLEK-EKSEYKME--IDDLSSNMEAVAKAKANLEKMcRTLEDQLSEIKSKndENLRQ 1271
Cdd:TIGR02169  155 RRKIIDEIAGVAEFDRKKEKALEELEEvEENIERLDliIDEKRQQLERLRREREKAERY-QALLKEKREYEGY--ELLKE 231
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1272 INDLSAQRARLQtengefgRQLEEKEALVSQLTRGKQAFTQQIEELKRQIEEEVKAKNALAhavqsarhdcdllreqfEE 1351
Cdd:TIGR02169  232 KEALERQKEAIE-------RQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLG-----------------EE 287
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1352 EQeakAELQRGMSKANSEVAQWRtkyetDAIqrtEELEESKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQGEVEDLM 1431
Cdd:TIGR02169  288 EQ---LRVKEKIGELEAEIASLE-----RSI---AEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLT 356
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1432 IDVERANALAANLDKKQRNFDKVLAEWKQKYEEGQAELEGAQKEARSLSTELFKMknsyeetLDQLETLKRENKNLQQEI 1511
Cdd:TIGR02169  357 EEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKRELDRL-------QEELQRLSEELADLNAAI 429
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1512 SDLTEQLGETGKSIHELEKSKKAVETEKAEIQTALEEAEGTLEHEESKILRVQLELNQVKSEIDRKLAEKD---EEIEQI 1588
Cdd:TIGR02169  430 AGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARaseERVRGG 509
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1589 KRNSQRITDSMQSTLDS-----EVRSR------------------------NDALRIKKKMEGD------LNEMEIQLSH 1633
Cdd:TIGR02169  510 RAVEEVLKASIQGVHGTvaqlgSVGERyataievaagnrlnnvvveddavaKEAIELLKRRKAGratflpLNKMRDERRD 589
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1634 ANRQA-----------AEAQKQLRNVQAQLKDAQLHLDDAVRGQEDM--------------------------------- 1669
Cdd:TIGR02169  590 LSILSedgvigfavdlVEFDPKYEPAFKYVFGDTLVVEDIEAARRLMgkyrmvtlegelfeksgamtggsraprggilfs 669
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1670 ---KEQVAMVERRNTLMQSEIEELRAALEQTERGRKVAEQELVDASERVGLLHSQNTSLLNTKKKLEADLVQIQSEVEDT 1746
Cdd:TIGR02169  670 rsePAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSL 749
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1747 VQEARNAEDKAKKAITDAAMMAEELKKEQDTSAHLERMkknlevtvkDLQHRLDEAENLAMKgGKKQLQKLESRVRELES 1826
Cdd:TIGR02169  750 EQEIENVKSELKELEARIEELEEDLHKLEEALNDLEAR---------LSHSRIPEIQAELSK-LEEEVSRIEARLREIEQ 819
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1827 EVEAEQRRGA-------DAVKGVRKYERRVKELTYQTEEDKKNVNRLQDLVDKLQLKVKAYKRQSEEAEEQANSHLSKLR 1899
Cdd:TIGR02169  820 KLNRLTLEKEylekeiqELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLR 899
                          810       820
                   ....*....|....*....|....*.
gi 288856329  1900 KVQHELEEAEERADIAESQVNKLRAK 1925
Cdd:TIGR02169  900 ELERKIEELEAQIEKKRKRLSELKAK 925
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
1003-1796 6.30e-21

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 100.58  E-value: 6.30e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1003 EAHQQTLDDLQAEEDKVNTL-TKSKTKLEQQVDDLEGSLEQ---EKKLRMDLERAKRKLEGDLK-LAQESIMDLENDKQQ 1077
Cdd:pfam15921   81 EEYSHQVKDLQRRLNESNELhEKQKFYLRQSVIDLQTKLQEmqmERDAMADIRRRESQSQEDLRnQLQNTVHELEAAKCL 160
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1078 SEEKLKKKDFETSQLLSKIEDEQSLGAQLQKKIKELQARIEELEEEIEAERAARAK-----VEKQRADLSRELEEISERL 1152
Cdd:pfam15921  161 KEDMLEDSNTQIEQLRKMMLSHEGVLQEIRSILVDFEEASGKKIYEHDSMSTMHFRslgsaISKILRELDTEISYLKGRI 240
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1153 EEAGGATAA-QIEMNKKREAEFQKLRRDLEESTLQHEATAAALRKKQADSVAELGEQIDNLQRVKQKLEKEKSEYKMEID 1231
Cdd:pfam15921  241 FPVEDQLEAlKSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQLEIIQEQARNQNSMYMRQLS 320
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1232 DLSSNmeaVAKAKANLEKMCRTLEDQLSEIKSKNDENLRQINDLSAQRARLQTENGEFGRQLEEkeaLVSQLTRGKQAFT 1311
Cdd:pfam15921  321 DLEST---VSQLRSELREAKRMYEDKIEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQK---LLADLHKREKELS 394
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1312 QQIEELKRQIEEEVKAKNALAHavqsarhdcdlLREQFEEEQeakAELQR--GMSKANSEVAQWRTKYETDAIQRTEELE 1389
Cdd:pfam15921  395 LEKEQNKRLWDRDTGNSITIDH-----------LRRELDDRN---MEVQRleALLKAMKSECQGQMERQMAAIQGKNESL 460
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1390 ESKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQGEVEDLMIDV---ERA-NALAANLDKKQRNFDKVLAEWKQKYEEG 1465
Cdd:pfam15921  461 EKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTVSDLTASLqekERAiEATNAEITKLRSRVDLKLQELQHLKNEG 540
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1466 QaELEGAQKEARSLSTELFKMKNSYEEtldqletlkrenknLQQEISDLTEQLGETGKSIHELEKSKKAVETEKAEIQTA 1545
Cdd:pfam15921  541 D-HLRNVQTECEALKLQMAEKDKVIEI--------------LRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRLE 605
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1546 LEEAEGTLEHEESKILRVQ-----LELNQVK-----SEIDRKLAEKDEEIEQIKRNSQRITDSMQS-TLDSEVRSRNdal 1614
Cdd:pfam15921  606 LQEFKILKDKKDAKIRELEarvsdLELEKVKlvnagSERLRAVKDIKQERDQLLNEVKTSRNELNSlSEDYEVLKRN--- 682
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1615 rIKKKMEgdlnEMEIQLSHANRQAAEAQKQLRNVQAQLKDAQLHLDDAVRGQEDMKEQVAMVERRNTLMQSEIEELRAAL 1694
Cdd:pfam15921  683 -FRNKSE----EMETTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAM 757
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1695 EQTERGRKVAEQELVDASERVgllhsqnTSLLNTKKKLEADLVQIQSEVEDTVQEARNAEDKAKKAITDAAMMAEELKKE 1774
Cdd:pfam15921  758 TNANKEKHFLKEEKNKLSQEL-------STVATEKNKMAGELEVLRSQERRLKEKVANMEVALDKASLQFAECQDIIQRQ 830
                          810       820
                   ....*....|....*....|..
gi 288856329  1775 QDTSAhleRMKKNLEVTVKDLQ 1796
Cdd:pfam15921  831 EQESV---RLKLQHTLDVKELQ 849
MYSc_Myo33 cd14894
class myosin, motor domain; Class XXXIII myosins have variable numbers of IQ domain and 2 ...
224-713 1.26e-20

class myosin, motor domain; Class XXXIII myosins have variable numbers of IQ domain and 2 tandem ANK repeats that are separated by a PH domain. The myosin classes XXX to XXXIV contain members from Phytophthora species and Hyaloperonospora parasitica. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276859 [Multi-domain]  Cd Length: 871  Bit Score: 99.43  E-value: 1.26e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  224 IIAANPLLEAYGNAKTVRNDNSSRFGKF--IRIHFGTSG---KLASADIETYLLEKSRVTFQLPDERG------YHIFYQ 292
Cdd:cd14894   249 VLDSNIVLEAFGHATTSMNLNSSRFGKMttLQVAFGLHPwefQICGCHISPFLLEKSRVTSERGRESGdqnelnFHILYA 328
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  293 MMT--NHKPEL----IEMTLITTNPYDFPMCSQGQITVASIDDKEELVATDT--------AIDILGFNNEEKMGIYKFTG 358
Cdd:cd14894   329 MVAgvNAFPFMrllaKELHLDGIDCSALTYLGRSDHKLAGFVSKEDTWKKDVerwqqvidGLDELNVSPDEQKTIFKVLS 408
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  359 AVLHHGNMKFKQKQREEQAEPDGT---EEADKIGYLLGLNSADMLKALCYPR---VKVGNEFVTKGQTVPQVYNSVSALS 432
Cdd:cd14894   409 AVLWLGNIELDYREVSGKLVMSSTgalNAPQKVVELLELGSVEKLERMLMTKsvsLQSTSETFEVTLEKGQVNHVRDTLA 488
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  433 KSIYERMFLWMVVRINQM-----LDTKQQRN------------FFIGVLDIAGFEIFDFNSMEQLCINFTNEKLqqfFNH 495
Cdd:cd14894   489 RLLYQLAFNYVVFVMNEAtkmsaLSTDGNKHqmdsnasapeavSLLKIVDVFGFEDLTHNSLDQLCINYLSEKL---YAR 565
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  496 HMFVLEQEEYKKEGIVWEfiDFGMDLaacIELIEKPLGIFSILEEECMFPKATDTSF-----KNKLYDQHLGKCNAFQKP 570
Cdd:cd14894   566 EEQVIAVAYSSRPHLTAR--DSEKDV---LFIYEHPLGVFASLEELTILHQSENMNAqqeekRNKLFVRNIYDRNSSRLP 640
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  571 KPAK--GKAEAH---------FSLVHYAGTVDYNISGWLDKNKDPLNES-VVQLYQKSSVKLLATL-------YPPVVEE 631
Cdd:cd14894   641 EPPRvlSNAKRHtpvllnvlpFVIPHTRGNVIYDANDFVKKNSDFVYANlLVGLKTSNSSHFCRMLnessqlgWSPNTNR 720
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  632 TggGKKGGKKKGGSMQTVSSQFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGF 711
Cdd:cd14894   721 S--MLGSAESRLSGTKSFVGQFRSHVNVLTSQDDKNMPFYFHCIRPNAKKQPSLVNNDLVEQQCRSQRLIRQMEICRNSS 798

                  ..
gi 288856329  712 PS 713
Cdd:cd14894   799 SS 800
PTZ00121 PTZ00121
MAEBL; Provisional
893-1623 1.81e-20

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 99.45  E-value: 1.81e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  893 VASESENLSDAEERCEGLIKSKIQLEAKLKETTERLEDEEEINAELTAKKRKLEDECSELKKdiddleltlaKVEKEKHA 972
Cdd:PTZ00121 1248 ERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKK----------KAEEAKKA 1317
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  973 TENKVKnlTEEMAAQDESIGKLTKEKKALQEAhqqtlddlqaeedkvntltkSKTKLEQQVDDLEGSLEQEKKLRMDLER 1052
Cdd:PTZ00121 1318 DEAKKK--AEEAKKKADAAKKKAEEAKKAAEA--------------------AKAEAEAAADEAEAAEEKAEAAEKKKEE 1375
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1053 AKRKLEGDLKLAQESIMDLENDKQQSEEKLKKKDFETSQLLSKIEDEQSLGAQLQKKIKELQARIEELEEEIEAeraara 1132
Cdd:PTZ00121 1376 AKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEA------ 1449
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1133 kveKQRADLSRELEEISERLEEAGGATAAQIEMNKKREAEfqKLRRDLEESTLQ-HEATAAALRKKQADSVAELGEQidn 1211
Cdd:PTZ00121 1450 ---KKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKAD--EAKKKAEEAKKKaDEAKKAAEAKKKADEAKKAEEA--- 1521
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1212 lqrvKQKLEKEKSEYKMEIDDLSSnmeavAKAKANLEKMCRTLEDQLSEIKSKNDENLRQindlsAQRARLQTENGEFGR 1291
Cdd:PTZ00121 1522 ----KKADEAKKAEEAKKADEAKK-----AEEKKKADELKKAEELKKAEEKKKAEEAKKA-----EEDKNMALRKAEEAK 1587
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1292 QLEEKEaLVSQLTRGKQAFTQQIEELKRQIEEEVKAKNalAHAVQSARHDCDLLREQFEEEQEAKAELQRGMSKANSEVA 1371
Cdd:PTZ00121 1588 KAEEAR-IEEVMKLYEEEKKMKAEEAKKAEEAKIKAEE--LKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAA 1664
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1372 QWRTKYETDAiQRTEEL----EESKKKLAQRLQEAEE--QIEAVNSKCASLEKTKQRLQGEVEDLMIDVERAnalaanld 1445
Cdd:PTZ00121 1665 EEAKKAEEDK-KKAEEAkkaeEDEKKAAEALKKEAEEakKAEELKKKEAEEKKKAEELKKAEEENKIKAEEA-------- 1735
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1446 KKQRNFDKVLAEWKQKYEEGQAELEGAQKEARSLSTELFKMKNSYEEtldqlETLKRENKNLQQEISDLTEQLGETGKSI 1525
Cdd:PTZ00121 1736 KKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIE-----EELDEEDEKRRMEVDKKIKDIFDNFANI 1810
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1526 HELEKSKKAV-----ETEKAEIQTALEEAEGTLEhEESKILRVQLELNQVKSEIDRKLA----EKD------EEIEQIKR 1590
Cdd:PTZ00121 1811 IEGGKEGNLVindskEMEDSAIKEVADSKNMQLE-EADAFEKHKFNKNNENGEDGNKEAdfnkEKDlkeddeEEIEEADE 1889
                         730       740       750
                  ....*....|....*....|....*....|...
gi 288856329 1591 NSQRITDSMQSTLDSEVRSRNDALRIKKKMEGD 1623
Cdd:PTZ00121 1890 IEKIDKDDIEREIPNNNMAGKNNDIIDDKLDKD 1922
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
1255-1936 4.16e-19

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 94.86  E-value: 4.16e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1255 EDQLSEIKSKNDENLRQINDLSAQRARLQTENGEFGRQLE-------EKEALVSQLTRGKQAFTQQIEELKRQIEEEVKA 1327
Cdd:pfam01576   11 EEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLQaetelcaEAEEMRARLAARKQELEEILHELESRLEEEEER 90
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1328 KNALAHAVQSARHDCDLLREQFEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEeLEESKKKLAQRLQEAEEQIE 1407
Cdd:pfam01576   91 SQQLQNEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLLEDQNSK-LSKERKLLEERISEFTSNLA 169
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1408 AVNSKCASLEKTKQRLQGEVEDLMIDVERANALAANLDKKQRNFDKVLAEWKQKYEEGQAELEGAQKEARSLSTELFKMK 1487
Cdd:pfam01576  170 EEEEKAKSLSKLKNKHEAMISDLEERLKKEEKGRQELEKAKRKLEGESTDLQEQIAELQAQIAELRAQLAKKEEELQAAL 249
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1488 NSYEETLDQLETLKRENKNLQQEISDLTEQLGETGKSIHELEKSKKAVETEKAEIQTALEEAEGTLEHEESKILRVQLEL 1567
Cdd:pfam01576  250 ARLEEETAQKNNALKKIRELEAQISELQEDLESERAARNKAEKQRRDLGEELEALKTELEDTLDTTAAQQELRSKREQEV 329
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1568 NQVKSEIDRKLAEKDEEIEQIKRNSQRITDSMQSTLDSEVRSRNDALRIKKKMEGDLNEMEIQLSHANRQAAEAQKQLRN 1647
Cdd:pfam01576  330 TELKKALEEETRSHEAQLQEMRQKHTQALEELTEQLEQAKRNKANLEKAKQALESENAELQAELRTLQQAKQDSEHKRKK 409
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1648 VQAQLKDAQLHLDDAVRGQEDMKEQVAMverrntlMQSEIEELRAALEQTErgrkvaeqelvdaservgllhSQNTslln 1727
Cdd:pfam01576  410 LEGQLQELQARLSESERQRAELAEKLSK-------LQSELESVSSLLNEAE---------------------GKNI---- 457
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1728 tkkKLEADLVQIQSEVEDTvQEARNAEDKAKKAIT--------DAAMMAEELKKEQDTSAHLERMKKNLEVTVKDLQHRL 1799
Cdd:pfam01576  458 ---KLSKDVSSLESQLQDT-QELLQEETRQKLNLStrlrqledERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKL 533
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1800 DE-AENL-AMKGGKKQLQK-LESRVRELESEVEAEQRrgadAVKGVRKYERRVKELTYQTEEDKKNVNRL---QDLVDKL 1873
Cdd:pfam01576  534 EEdAGTLeALEEGKKRLQReLEALTQQLEEKAAAYDK----LEKTKNRLQQELDDLLVDLDHQRQLVSNLekkQKKFDQM 609
                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 288856329  1874 QLKVKA----YKRQSEEAEEQANSHLSKLRKVQHELEEAEERADIAESQVNKLRAKSRDSGKGKDAA 1936
Cdd:pfam01576  610 LAEEKAisarYAEERDRAEAEAREKETRALSLARALEEALEAKEELERTNKQLRAEMEDLVSSKDDV 676
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
1416-1925 4.69e-19

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 94.41  E-value: 4.69e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1416 LEKTKQRLQGEVEDLMIDVERANALAanlDKKQRNFDKVLAEWKQKYEEGQAELEGAQKEARSLSTELFKMKNSYEETLD 1495
Cdd:pfam15921   76 IERVLEEYSHQVKDLQRRLNESNELH---EKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRESQSQEDLRNQLQNTVH 152
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1496 QLETLKRENKNLQQEISDLTEQLgetgksiHELEKSKKAVETEKAEIQTALEEAEGTLEHEESKIlrVQLELNQVKSEID 1575
Cdd:pfam15921  153 ELEAAKCLKEDMLEDSNTQIEQL-------RKMMLSHEGVLQEIRSILVDFEEASGKKIYEHDSM--STMHFRSLGSAIS 223
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1576 RKLAEKDEEIEQIKRNSQRITDSMQsTLDSEVRSRNDAL--RIKKKMEGDLNEMEIQLSHANRQAAEAQKQLRNVQAQLK 1653
Cdd:pfam15921  224 KILRELDTEISYLKGRIFPVEDQLE-ALKSESQNKIELLlqQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQLE 302
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1654 DAQlhlddavrgqEDMKEQVAMVERRNTLMQSEIEELRAALEQTERgrkVAEQELVDASERVGLLHSQntsllntkkkle 1733
Cdd:pfam15921  303 IIQ----------EQARNQNSMYMRQLSDLESTVSQLRSELREAKR---MYEDKIEELEKQLVLANSE------------ 357
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1734 adLVQIQSEVEDTVQEARNAEDKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEVTVKDLQHRLDEAenlamkggKKQ 1813
Cdd:pfam15921  358 --LTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDDR--------NME 427
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1814 LQKLESRVRELESEVEAEQRRGADAVKGVRKYERRVKELTYQTEEDKKnvnRLQDLVDKLqlkvkAYKRQSEEAEEQANS 1893
Cdd:pfam15921  428 VQRLEALLKAMKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKE---MLRKVVEEL-----TAKKMTLESSERTVS 499
                          490       500       510
                   ....*....|....*....|....*....|..
gi 288856329  1894 HLSKlrkvqhELEEAEERADIAESQVNKLRAK 1925
Cdd:pfam15921  500 DLTA------SLQEKERAIEATNAEITKLRSR 525
PTZ00121 PTZ00121
MAEBL; Provisional
1169-1913 7.21e-19

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 94.44  E-value: 7.21e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1169 REAEFQKLRRDLEESTLQHEATAAALRKKQADSVAElgEQIDNLQRVKQKLEKEKSEYKMEIDDLSSNMEAVAKAKANLE 1248
Cdd:PTZ00121 1077 KDFDFDAKEDNRADEATEEAFGKAEEAKKTETGKAE--EARKAEEAKKKAEDARKAEEARKAEDARKAEEARKAEDAKRV 1154
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1249 KMCRTLEDQLSEIKSKNDENLRQIndlSAQRARLQTENGEFGRQLEEkealVSQLTRGKQAFTQQIEELKRQIEEEVKAK 1328
Cdd:PTZ00121 1155 EIARKAEDARKAEEARKAEDAKKA---EAARKAEEVRKAEELRKAED----ARKAEAARKAEEERKAEEARKAEDAKKAE 1227
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1329 NAlaHAVQSARHDcdllreqfeEEQEAKAELQRGmskaNSEVAQWRTKYETDAIQRTEELEESKKKLAQRLQEAEEQIEA 1408
Cdd:PTZ00121 1228 AV--KKAEEAKKD---------AEEAKKAEEERN----NEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKA 1292
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1409 VNSKCASLEKTKQRLQGEVEDlmidveraNALAANLDKKQRNFDKVLAEWKQKYEEGQAELEGAQKEARSLSTELFKMKN 1488
Cdd:PTZ00121 1293 DEAKKAEEKKKADEAKKKAEE--------AKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEE 1364
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1489 SYEEtlDQLETLKRENKnlqqeisdlTEQLGETGKSIHELEKSKKAVETEKAEIQTALEEAEGTLEHEESKILRVQLEln 1568
Cdd:PTZ00121 1365 KAEA--AEKKKEEAKKK---------ADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKK-- 1431
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1569 qvKSEIDRKLAEKDEEIEQIKRNSQRITDSMQSTLDSEVRSRNDALRIKKKMEGDLNEMEIQLSHANRQAAEAQKQlrnV 1648
Cdd:PTZ00121 1432 --KADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKA---A 1506
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1649 QAQLKDAQLHLDDAVRGQEDMK---EQVAMVERRNTLMQSEIEELRAA--LEQTERGRKVaEQELVDASERVGLLHSQNT 1723
Cdd:PTZ00121 1507 EAKKKADEAKKAEEAKKADEAKkaeEAKKADEAKKAEEKKKADELKKAeeLKKAEEKKKA-EEAKKAEEDKNMALRKAEE 1585
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1724 SLLNTKKKLEADLVQIQSEVEDTVQEARNAEDKAKKAitdaammaEELKKEQDTSAHLERMKKNLEVTVKDLQH-RLDEA 1802
Cdd:PTZ00121 1586 AKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKA--------EELKKAEEEKKKVEQLKKKEAEEKKKAEElKKAEE 1657
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1803 ENLAMKGGKKQLQKLESRVRELESEVEAEQRRGADAVKGVRKYERRVKELTYQTEEDKKNVNRLQDL-------VDKLQL 1875
Cdd:PTZ00121 1658 ENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAeeenkikAEEAKK 1737
                         730       740       750
                  ....*....|....*....|....*....|....*...
gi 288856329 1876 KVKAYKRQSEEAEEQANSHlsklRKVQHELEEAEERAD 1913
Cdd:PTZ00121 1738 EAEEDKKKAEEAKKDEEEK----KKIAHLKKEEEKKAE 1771
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
1302-1907 2.51e-18

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 92.10  E-value: 2.51e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1302 QLTRGKQAFTQQIEELKRQIEEEVKAKNALAHAVQSARHDCDLLREQFEEEQEAKAELQRGMSKANSEVaqwrtkyeTDA 1381
Cdd:pfam15921   75 HIERVLEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRESQSQEDL--------RNQ 146
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1382 IQRT-EELEESKKKLAQRLQEAEEQIEAVNSKCASLEKTKQrlqgEVEDLMIDVERANAlaanldkkqrnfdkvlaewKQ 1460
Cdd:pfam15921  147 LQNTvHELEAAKCLKEDMLEDSNTQIEQLRKMMLSHEGVLQ----EIRSILVDFEEASG-------------------KK 203
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1461 KYEEGQAEL-------EGAQKEARSLSTELFKMKNSYEETLDQLETLKRENKN----LQQEISDLTEQL-GETGKSIHEL 1528
Cdd:pfam15921  204 IYEHDSMSTmhfrslgSAISKILRELDTEISYLKGRIFPVEDQLEALKSESQNkielLLQQHQDRIEQLiSEHEVEITGL 283
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1529 EKSKKAVETEKAEIQTALEEAEGTLEHEESKILRVQLEL----NQVKSEI---DRKLAEKDEEIE--------------- 1586
Cdd:pfam15921  284 TEKASSARSQANSIQSQLEIIQEQARNQNSMYMRQLSDLestvSQLRSELreaKRMYEDKIEELEkqlvlanselteart 363
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1587 ---QIKRNSQRITDSMQSTLdSEVRSRNDALRIKKKMEGDLNEME----IQLSHANRQAAEAQKQLRNVQAQLKDaqlhL 1659
Cdd:pfam15921  364 erdQFSQESGNLDDQLQKLL-ADLHKREKELSLEKEQNKRLWDRDtgnsITIDHLRRELDDRNMEVQRLEALLKA----M 438
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1660 DDAVRGQedMKEQVAMVERRNTLMQsEIEELRAALEQT-ERGRKVAEQ-----ELVDASERVglLHSQNTSLLNTKKKLE 1733
Cdd:pfam15921  439 KSECQGQ--MERQMAAIQGKNESLE-KVSSLTAQLESTkEMLRKVVEEltakkMTLESSERT--VSDLTASLQEKERAIE 513
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1734 A---DLVQIQSEVEDTVQEA---RNAEDKAKKAITDAA----MMAEELKKEQDTSAHLERM-----------------KK 1786
Cdd:pfam15921  514 AtnaEITKLRSRVDLKLQELqhlKNEGDHLRNVQTECEalklQMAEKDKVIEILRQQIENMtqlvgqhgrtagamqveKA 593
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1787 NLEVTVKDLQHRLDEAENLAMKGGKKqLQKLESRVRELESEVEAEQRRGADAVKGVRKYERRVKELTyqtEEDKKNVNRL 1866
Cdd:pfam15921  594 QLEKEINDRRLELQEFKILKDKKDAK-IRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLL---NEVKTSRNEL 669
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|.
gi 288856329  1867 QDLVDKLQLKVKAYKRQSEEAEEQANSHLSKLRKVQHELEE 1907
Cdd:pfam15921  670 NSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQ 710
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
957-1589 2.53e-18

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 91.62  E-value: 2.53e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   957 DDLELTLAKVEKEKHATENKVKNLTEEMAAQDESIGKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKS----------- 1025
Cdd:TIGR04523   36 KQLEKKLKTIKNELKNKEKELKNLDKNLNKDEEKINNSNNKIKILEQQIKDLNDKLKKNKDKINKLNSDlskinseiknd 115
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1026 ---KTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDLENDKQQSEEKLKKKDFETSQLLSKIEDEQSL 1102
Cdd:TIGR04523  116 keqKNKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNIDKIKNK 195
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1103 GAQLQKKIKELQarieELEEEIEAERAARAKVEKQRADLSRELEEISERLEEaggataaqiemnkkREAEFQKLRRDLEE 1182
Cdd:TIGR04523  196 LLKLELLLSNLK----KKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINE--------------KTTEISNTQTQLNQ 257
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1183 STLQHEATAAALRKKQadsvaelgEQIDNLQRVKQKLEKEKSEYKMEIDDLSSNMEA-----VAKAKANLEKMCRTLEDQ 1257
Cdd:TIGR04523  258 LKDEQNKIKKQLSEKQ--------KELEQNNKKIKELEKQLNQLKSEISDLNNQKEQdwnkeLKSELKNQEKKLEEIQNQ 329
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1258 LSEIKSKNDENLRQINDLSAQRARLQTENGEFGRQLEEKEALVSQLTRGKQAFTQQIEELKRQIeeevkakNALAHAVQS 1337
Cdd:TIGR04523  330 ISQNNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQI-------NDLESKIQN 402
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1338 ARHDCDLLREQFEEEQEAKAELQRGMSKANSEVAQWRTKYEtDAIQRTEELEESKKKLAQRLQEAEEQIEAVNSKCASLE 1417
Cdd:TIGR04523  403 QEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIK-DLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIK 481
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1418 KTKQRLQGEVEDLMIDVERANALAANLDKKQRNFDKVLAEWKQKYEEGQAELEGAQKEARSLSTELFKMKnsYEETLDQL 1497
Cdd:TIGR04523  482 QNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEDELNKDD--FELKKENL 559
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1498 ETLKRENknlQQEISDLTEQLGETGKSIHELEKSKKAVETEKAEIQTALEEAE---GTLEHEESKILRVQLELNQVKSEI 1574
Cdd:TIGR04523  560 EKEIDEK---NKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEkkiSSLEKELEKAKKENEKLSSIIKNI 636
                          650
                   ....*....|....*
gi 288856329  1575 DRKLAEKDEEIEQIK 1589
Cdd:TIGR04523  637 KSKKNKLKQEVKQIK 651
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
845-1516 3.56e-18

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 91.66  E-value: 3.56e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   845 AETEKELATMKEDFVKCKEDLAKAEAKKKELEEKMVALLQEKNDLQLAVASESENLSDAEERCEGLIKSKIQLEAKLKET 924
Cdd:TIGR02168  340 AELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERL 419
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   925 TERLEDEEEINAEltAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAAQDESIgkltKEKKALQEA 1004
Cdd:TIGR02168  420 QQEIEELLKKLEE--AELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAEREL----AQLQARLDS 493
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1005 HQQTLDDLQAEEDKVNTLTKSKTKLEQQVDDLEGSLEQEKKLRMDLERAkrkLEGDLklaQESIMDLENDKQQSEEKLKK 1084
Cdd:TIGR02168  494 LERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISVDEGYEAAIEAA---LGGRL---QAVVVENLNAAKKAIAFLKQ 567
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1085 KDFETSQLLskiEDEQSLGAQLQKKIKELQARIEELEEEIEAERAARAKVEKQRADL----------------------- 1141
Cdd:TIGR02168  568 NELGRVTFL---PLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLlggvlvvddldnalelakklrpg 644
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1142 -------------------------------SRELEEISERLEEAGG-ATAAQIEMNKKR------EAEFQKLRRDLEES 1183
Cdd:TIGR02168  645 yrivtldgdlvrpggvitggsaktnssilerRREIEELEEKIEELEEkIAELEKALAELRkeleelEEELEQLRKELEEL 724
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1184 TLQHEATAAALRKKQAdSVAELGEQIDNLQRVKQKLEKEKSEYKMEIDDLSSNMEAVAKAKANLEKMCRTLEDQLSEIKS 1263
Cdd:TIGR02168  725 SRQISALRKDLARLEA-EVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALRE 803
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1264 KndenlrqindLSAQRARLQTENGEFGRQLEEKEalvsQLTRGKQAFTQQIEELKRQIEEEVKAKNALAHAVQSARHDCD 1343
Cdd:TIGR02168  804 A----------LDELRAELTLLNEEAANLRERLE----SLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIE 869
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1344 LLREQFEEEQEAKAELQRGMSKANSEvaqwrtkyETDAIQRTEELEESKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRL 1423
Cdd:TIGR02168  870 ELESELEALLNERASLEEALALLRSE--------LEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNL 941
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1424 QgevedlmidvERANALAanldkkQRNFDKVLAewkqKYEEGQAELEGAQKEARSLSTELFKMKNSYEETLDQLETLKRE 1503
Cdd:TIGR02168  942 Q----------ERLSEEY------SLTLEEAEA----LENKIEDDEEEARRRLKRLENKIKELGPVNLAAIEEYEELKER 1001
                          730
                   ....*....|...
gi 288856329  1504 NKNLQQEISDLTE 1516
Cdd:TIGR02168 1002 YDFLTAQKEDLTE 1014
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
896-1761 4.33e-18

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 91.65  E-value: 4.33e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   896 ESENLSDAEERCEGLIKSKIQLEAKLKETTERLEDEEEINAELTAKKRKLEDECSELKKDIDdleltlakvekekHATEN 975
Cdd:TIGR00606  246 ELDPLKNRLKEIEHNLSKIMKLDNEIKALKSRKKQMEKDNSELELKMEKVFQGTDEQLNDLY-------------HNHQR 312
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   976 KVKNLTEEMAAQDESIGKLTKEKKALQEAH-----QQTLDDLQAEEDKVNTLTKSKTKLEQQ----VDDLEGSLEQEKKL 1046
Cdd:TIGR00606  313 TVREKERELVDCQRELEKLNKERRLLNQEKtellvEQGRLQLQADRHQEHIRARDSLIQSLAtrleLDGFERGPFSERQI 392
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1047 RMDLERAKRKLEGDLKLAQESIMDLENDKQQSEEKLKKKDFETSQLLSKIEDEQSLGAQLQKKIKELQARIEELEEEIEA 1126
Cdd:TIGR00606  393 KNFHTLVIERQEDEAKTAAQLCADLQSKERLKQEQADEIRDEKKGLGRTIELKKEILEKKQEELKFVIKELQQLEGSSDR 472
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1127 ERAARAKVEKQRADLSRELEEiserleeaggataAQIEMNKKREAEFQKLRRDLEEStlqheataaalRKKQADSVAELG 1206
Cdd:TIGR00606  473 ILELDQELRKAERELSKAEKN-------------SLTETLKKEVKSLQNEKADLDRK-----------LRKLDQEMEQLN 528
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1207 EQIDNLQRVkQKLEKEKSEYKMEIDDLSSNMEAVAKAKANLEKMCRTLEDQLSEIKSKNDENLRQINDLSAQRARLQTEN 1286
Cdd:TIGR00606  529 HHTTTRTQM-EMLTKDKMDKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASLEQNK 607
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1287 GEFGRQLEEKEALVSQLTR------GKQAFTQQIEELKRQIEEEVKAKNALAHAvqSARHDcDLLREQFEEEQEAKAELQ 1360
Cdd:TIGR00606  608 NHINNELESKEEQLSSYEDklfdvcGSQDEESDLERLKEEIEKSSKQRAMLAGA--TAVYS-QFITQLTDENQSCCPVCQ 684
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1361 RgmskansevaqwrtkyetdAIQRTEELEESKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQGEVEDLMIDVERANAL 1440
Cdd:TIGR00606  685 R-------------------VFQTEAELQEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKE 745
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1441 AANLDKKQRNFDKVLAEWKQKYEEGQAELE---GAQKEARSLSTELFKMKNSYEETldqletlKRENKNLQQEISDLteQ 1517
Cdd:TIGR00606  746 IPELRNKLQKVNRDIQRLKNDIEEQETLLGtimPEEESAKVCLTDVTIMERFQMEL-------KDVERKIAQQAAKL--Q 816
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1518 LGETGKSIHELEKSKKAVETEKAEIQTALEEAEGTLEHEESKILRVQLELNQVKSEiDRKLAEKDEEIEQIKRNSQRITD 1597
Cdd:TIGR00606  817 GSDLDRTVQQVNQEKQEKQHELDTVVSKIELNRKLIQDQQEQIQHLKSKTNELKSE-KLQIGTNLQRRQQFEEQLVELST 895
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1598 SMQSTLDSEVRSRNDALRIKKKMEGDLNEMEIQLSHANRQAAEAQKQLRNVQAQLKDAQLHLDDAVRGQEDMKEQVAMVE 1677
Cdd:TIGR00606  896 EVQSLIREIKDAKEQDSPLETFLEKDQQEKEELISSKETSNKKAQDKVNDIKEKVKNIHGYMKDIENKIQDGKDDYLKQK 975
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1678 rrntlmQSEIEELRAALEQTERGRKVAEQELVDASERVGLLHSQNTSLLN--TKKKLEADLVQIQSEV--------EDTV 1747
Cdd:TIGR00606  976 ------ETELNTVNAQLEECEKHQEKINEDMRLMRQDIDTQKIQERWLQDnlTLRKRENELKEVEEELkqhlkemgQMQV 1049
                          890
                   ....*....|....
gi 288856329  1748 QEARNAEDKAKKAI 1761
Cdd:TIGR00606 1050 LQMKQEHQKLEENI 1063
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
956-1550 8.82e-18

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 90.12  E-value: 8.82e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  956 IDDLELTLAKVEKEKHATENKVKNLtEEMAAQDESIGKLTKEKKalqeahqqtlDDLQAEEDKVNTLTKSKTKLEQQVDD 1035
Cdd:PRK03918  157 LDDYENAYKNLGEVIKEIKRRIERL-EKFIKRTENIEELIKEKE----------KELEEVLREINEISSELPELREELEK 225
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1036 LEGSLEQEKKLRMDLERAKRKLEGDLKlaqeSIMDLENDKQQSEEKLKKKDFETSQLLSKIEDeqslgaqlQKKIKELQA 1115
Cdd:PRK03918  226 LEKEVKELEELKEEIEELEKELESLEG----SKRKLEEKIRELEERIEELKKEIEELEEKVKE--------LKELKEKAE 293
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1116 RIEELEEEIEAERAARAKVEKQRADLSRELEEISERLEEAGGATAAQIEMNKKREaefqKLRRDLEESTLQHEATAAALR 1195
Cdd:PRK03918  294 EYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLK----ELEKRLEELEERHELYEEAKA 369
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1196 KKqadsvaelgeqiDNLQRVKQKLEKEkseykmEIDDLSSNMEAVAKAKANLEKMCRTLEDQLSEIKSKNDENLRQINDL 1275
Cdd:PRK03918  370 KK------------EELERLKKRLTGL------TPEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEEL 431
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1276 SAQRA------RLQTENGEfGRQLEEKEALVSQLTRGKQAFTQQIEELKRQiEEEVKAKNALAHAVQSARHDCDLLREQF 1349
Cdd:PRK03918  432 KKAKGkcpvcgRELTEEHR-KELLEEYTAELKRIEKELKEIEEKERKLRKE-LRELEKVLKKESELIKLKELAEQLKELE 509
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1350 E-------EEQEAKAELQRGMSKANSEVAQwRTKYETDAIQRTEELEESKKKLAQRLQEAEEQIEAVNSKCASLE-KTKQ 1421
Cdd:PRK03918  510 EklkkynlEELEKKAEEYEKLKEKLIKLKG-EIKSLKKELEKLEELKKKLAELEKKLDELEEELAELLKELEELGfESVE 588
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1422 RLQGEVEDLMIDVERANALAaNLDKKQRNFDKVLAEWKQKYEEGQAELEGAQKEARSLSTELFKMKNSYEEtlDQLETLK 1501
Cdd:PRK03918  589 ELEERLKELEPFYNEYLELK-DAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYSE--EEYEELR 665
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*....
gi 288856329 1502 RENKNLQQEISDLTEQLGETGKSIHELEKSKKAVETEKAEIQTALEEAE 1550
Cdd:PRK03918  666 EEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEEREKAKKELE 714
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1210-1898 9.85e-18

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 90.12  E-value: 9.85e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1210 DNLQRVKQKLEKEKSEYKMEIddlssnmeavaKAKANLEKMCRTLEDQLSEIkskndenLRQINDLSAQRARLQTENGEF 1289
Cdd:PRK03918  165 KNLGEVIKEIKRRIERLEKFI-----------KRTENIEELIKEKEKELEEV-------LREINEISSELPELREELEKL 226
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1290 GRQLEEKEALVSQltrgkqaftqqIEELKRQIEEEVKAKNALAHAVQSARHDCDLLREQFEEEQEAKAELQ--RGMSKAN 1367
Cdd:PRK03918  227 EKEVKELEELKEE-----------IEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKelKEKAEEY 295
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1368 SEVAQWRTKYEtdaiQRTEELEESKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQGEVEDLMidveranalaanldkk 1447
Cdd:PRK03918  296 IKLSEFYEEYL----DELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLE---------------- 355
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1448 qrnfdkVLAEWKQKYEEGQAELEgaqkEARSLSTELfkMKNSYEETLDQLETLKRENKNLQQEISDLTEQLGETGKSIHE 1527
Cdd:PRK03918  356 ------ELEERHELYEEAKAKKE----ELERLKKRL--TGLTPEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKE 423
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1528 LEKSkkAVETEKAEIQTALEEAEGTLEHEESKILRVQLELNQVKSEidrkLAEKDEEIEQIKRNsqritdsmqstldsev 1607
Cdd:PRK03918  424 LKKA--IEELKKAKGKCPVCGRELTEEHRKELLEEYTAELKRIEKE----LKEIEEKERKLRKE---------------- 481
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1608 rsrndalriKKKMEGDLNEMEIQLShaNRQAAEaqkQLRNVQAQLKDAQLH-LDDAVRGQEDMKEQVAMVERRNTLMQSE 1686
Cdd:PRK03918  482 ---------LRELEKVLKKESELIK--LKELAE---QLKELEEKLKKYNLEeLEKKAEEYEKLKEKLIKLKGEIKSLKKE 547
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1687 IEELraalEQTERGRKVAEQELVDASERVGLLHsqntsllntkKKLEADLVQIQSEVEDTVQEARNAEDK---AKKAITD 1763
Cdd:PRK03918  548 LEKL----EELKKKLAELEKKLDELEEELAELL----------KELEELGFESVEELEERLKELEPFYNEyleLKDAEKE 613
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1764 AAMMAEELKKEQDTsahLERMKKNLEVTVKDLQHRLDEAENLAMKGGKKQLQKLESRVRELESEVEAEQRRGADAVKGVR 1843
Cdd:PRK03918  614 LEREEKELKKLEEE---LDKAFEELAETEKRLEELRKELEELEKKYSEEEYEELREEYLELSRELAGLRAELEELEKRRE 690
                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 288856329 1844 KYERRVKELTYQTEEDKKNVNRLQDL------VDKLQLKVKAYKrqsEEAEEQANSHLSKL 1898
Cdd:PRK03918  691 EIKKTLEKLKEELEEREKAKKELEKLekalerVEELREKVKKYK---ALLKERALSKVGEI 748
PTZ00121 PTZ00121
MAEBL; Provisional
966-1834 1.53e-17

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 89.82  E-value: 1.53e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  966 VEKEKHATENKVKNLTEEMAAQDESIGKLTKEKKALQEAHQQTLDDLQAEEdkvnTLTKSKTKLEQQVDDLEGSLEQEKK 1045
Cdd:PTZ00121 1041 VLKEKDIIDEDIDGNHEGKAEAKAHVGQDEGLKPSYKDFDFDAKEDNRADE----ATEEAFGKAEEAKKTETGKAEEARK 1116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1046 LrmdlERAKRKLEgDLKLAQESimDLENDKQQSEEKLKKKDFETSQLLSKIED----EQSLGAQLQKKIKELQARIEELE 1121
Cdd:PTZ00121 1117 A----EEAKKKAE-DARKAEEA--RKAEDARKAEEARKAEDAKRVEIARKAEDarkaEEARKAEDAKKAEAARKAEEVRK 1189
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1122 EEIEAERAARAKVEK-QRADLSRELEEISERLEEAGGATAAQIEMNKKREAEFQKLR--RDLEESTLQHEATAAALRKKQ 1198
Cdd:PTZ00121 1190 AEELRKAEDARKAEAaRKAEEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEeeRNNEEIRKFEEARMAHFARRQ 1269
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1199 ADSVAELGEQIDNLQR---VKQKLEKEKSEYKMEIDDLSSNMEAVAKAKaNLEKMCRTLEDQLSEIKSKNDENLRQIndl 1275
Cdd:PTZ00121 1270 AAIKAEEARKADELKKaeeKKKADEAKKAEEKKKADEAKKKAEEAKKAD-EAKKKAEEAKKKADAAKKKAEEAKKAA--- 1345
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1276 SAQRARLQTENGEFGRQLEEKEALVSQLTRGKQaftqQIEELKRQIEEEVKAKNALAHAvqsarhdcdllreqfeEEQEA 1355
Cdd:PTZ00121 1346 EAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKK----KADAAKKKAEEKKKADEAKKKA----------------EEDKK 1405
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1356 KAELQRGMSKANSEVAQWRTKYETdaIQRTEELE---ESKKKLAQRLQEAEEQIEAVNSKCASLEKTKqrlqgevedlmi 1432
Cdd:PTZ00121 1406 KADELKKAAAAKKKADEAKKKAEE--KKKADEAKkkaEEAKKADEAKKKAEEAKKAEEAKKKAEEAKK------------ 1471
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1433 dveranalAANLDKKqrnfdkvlAEWKQKYEEGQAELEGAQKEARSLstelfkmKNSYEETLDQLETLKRENKNLQQEIS 1512
Cdd:PTZ00121 1472 --------ADEAKKK--------AEEAKKADEAKKKAEEAKKKADEA-------KKAAEAKKKADEAKKAEEAKKADEAK 1528
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1513 DLTEQlgETGKSIHELEKSKKAVETEKAEiqtALEEAEGTLEHEESKILRVQLELNQVKSEIDRKLAEKDEEIEQIKRNS 1592
Cdd:PTZ00121 1529 KAEEA--KKADEAKKAEEKKKADELKKAE---ELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEE 1603
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1593 QRITDSMQSTLDSEVRSRNDALRIKKKMEGDLNEMEIQLSHANRQAAEAQKQlrnvqaqlkdaqlhlddavrgQEDMKEQ 1672
Cdd:PTZ00121 1604 EKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKA---------------------EEENKIK 1662
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1673 VAMVERRNTLMQSEIEELRAALEQTergRKVAEQELVDASErvgllhsqntsllntKKKLEadlvqiqsEVEDTVQEARN 1752
Cdd:PTZ00121 1663 AAEEAKKAEEDKKKAEEAKKAEEDE---KKAAEALKKEAEE---------------AKKAE--------ELKKKEAEEKK 1716
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1753 AEDKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEVTVKDLQHRLDEAENLAMKGGKKQLQKLESRVRELESEVEAEQ 1832
Cdd:PTZ00121 1717 KAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEV 1796

                  ..
gi 288856329 1833 RR 1834
Cdd:PTZ00121 1797 DK 1798
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
1084-1763 2.99e-17

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 88.15  E-value: 2.99e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1084 KKDFETSQLLSKIEDEQSLGAQLQKKIKELQARIEELEEEIEAERAARAKVEKQRADLSRELEEISERLEEAGGAT---A 1160
Cdd:TIGR04523   30 KQDTEEKQLEKKLKTIKNELKNKEKELKNLDKNLNKDEEKINNSNNKIKILEQQIKDLNDKLKKNKDKINKLNSDLskiN 109
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1161 AQIEMNK----KREAEFQKLRRDLEESTLQHEATAAALRKKQADsVAELGEQIDNLQRVKQKLEKEKSEYKMEIDDLSSN 1236
Cdd:TIGR04523  110 SEIKNDKeqknKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKE-LEKLNNKYNDLKKQKEELENELNLLEKEKLNIQKN 188
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1237 MeavakakANLEKMCRTLEDQLSEIKSKNDENlrqiNDLSAQRARLQTENGEFGRQLEEKEALVSQLTRGKQAFTQQIEE 1316
Cdd:TIGR04523  189 I-------DKIKNKLLKLELLLSNLKKKIQKN----KSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQ 257
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1317 LKrqiEEEVKAKNALAHAVQSARHDCDLLREQFEEEQEAKAELqrgmSKANSEVAQ-WRTKYETDAIQRTEELEESKKKL 1395
Cdd:TIGR04523  258 LK---DEQNKIKKQLSEKQKELEQNNKKIKELEKQLNQLKSEI----SDLNNQKEQdWNKELKSELKNQEKKLEEIQNQI 330
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1396 AQrlqeAEEQIEAVNSKCASLEKTKQRLQGEVEDLMIDVERANALAANLDKKQRNFDKVLAEWKQKYEEGQAELEGAQKE 1475
Cdd:TIGR04523  331 SQ----NNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKL 406
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1476 ARSLSTELFKMKNSYEETLDQLETLKRENKNLQQEISDLTEQLGETGKSIHELEKSKKAVET-------EKAEIQTALEE 1548
Cdd:TIGR04523  407 NQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETqlkvlsrSINKIKQNLEQ 486
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1549 AEGTLEHEESKILrvqlELNQVKSEIDRKLAEKDEEIEQIKrNSQRITDSMQSTLDSEVRSRNDALrIKKKMEGDLNEME 1628
Cdd:TIGR04523  487 KQKELKSKEKELK----KLNEEKKELEEKVKDLTKKISSLK-EKIEKLESEKKEKESKISDLEDEL-NKDDFELKKENLE 560
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1629 IQLSHANRQAaeaqKQLRNVQAQLKDAQLHLDDAVRGQEDmkeqvamverrntlmqsEIEELRAALEQTERGRKVAEQEL 1708
Cdd:TIGR04523  561 KEIDEKNKEI----EELKQTQKSLKKKQEEKQELIDQKEK-----------------EKKDLIKEIEEKEKKISSLEKEL 619
                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 288856329  1709 VDASERVGLLHSQNTSLLNTKKKLEADLVQIQSEVEDTVQEARNAEDKAKKAITD 1763
Cdd:TIGR04523  620 EKAKKENEKLSSIIKNIKSKKNKLKQEVKQIKETIKEIRNKWPEIIKKIKESKTK 674
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
843-1457 5.30e-17

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 87.82  E-value: 5.30e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   843 KSAETEKELATMKEDFVKCKEDLAKAEAKKKELEEKMVALLQEKNDLQLAVASESENLSDAEERCEGLIKSKIQLEAKLK 922
Cdd:TIGR02169  379 EFAETRDELKDYREKLEKLKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLE 458
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   923 ETTERLEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAAQDESIGKLTKEK---- 998
Cdd:TIGR02169  459 QLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQGVHGTVAQLGSVGerya 538
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   999 KALQEAHQQTLDDLQAEED--------------------------KVNTLTKSKTKLEQQVDDLEGSLEQEKKLR----- 1047
Cdd:TIGR02169  539 TAIEVAAGNRLNNVVVEDDavakeaiellkrrkagratflplnkmRDERRDLSILSEDGVIGFAVDLVEFDPKYEpafky 618
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1048 --------MDLERAKR--------KLEGDL--------------KLAQESIMDLENDKQQSEEKLKKKDFETSQLLSKIE 1097
Cdd:TIGR02169  619 vfgdtlvvEDIEAARRlmgkyrmvTLEGELfeksgamtggsrapRGGILFSRSEPAELQRLRERLEGLKRELSSLQSELR 698
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1098 DEQSLGAQLQKKIKELQARIEELEEEIEAERAARAKVEKQRADLSRELEEISERLEEAggataaqiemnkkrEAEFQKLR 1177
Cdd:TIGR02169  699 RIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENV--------------KSELKELE 764
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1178 RDLEEstlqHEATAAALRKKQADSVAELG-EQIDNLQRVKQKLEKEKSEYKMEIDDLSSNMEAVAKAKANLEKMCRTLED 1256
Cdd:TIGR02169  765 ARIEE----LEEDLHKLEEALNDLEARLShSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQE 840
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1257 QLSEIKSKNDENLRQINDLSAQRARLQTEngefgrqLEEKEALVSQLTRGKQAFTQQIEELKRQIEEEVKAKNALAHAVQ 1336
Cdd:TIGR02169  841 QRIDLKEQIKSIEKEIENLNGKKEELEEE-------LEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIE 913
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1337 SARHDCDLLREQFEEEQEAKAELqrgmskansEVAQWRTKYETDAIQRTEELEESKKKLAQRLQE-------AEEQIEAV 1409
Cdd:TIGR02169  914 KKRKRLSELKAKLEALEEELSEI---------EDPKGEDEEIPEEELSLEDVQAELQRVEEEIRAlepvnmlAIQEYEEV 984
                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|...
gi 288856329  1410 NSKCASLEKTKQRLQGEVEDL-----MIDVERANALAANLDKKQRNFDKVLAE 1457
Cdd:TIGR02169  985 LKRLDELKEKRAKLEEERKAIlerieEYEKKKREVFMEAFEAINENFNEIFAE 1037
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
902-1551 5.80e-17

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 87.72  E-value: 5.80e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   902 DAEERCEGLIKSKIQLEAKLKETTERLEDEEEINAELTAK------KRKLEDECSELKKDIDDLELTLAKVEKEKHATE- 974
Cdd:TIGR00618  209 CTPCMPDTYHERKQVLEKELKHLREALQQTQQSHAYLTQKreaqeeQLKKQQLLKQLRARIEELRAQEAVLEETQERINr 288
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   975 -NKVKNLTEEMAA------QDESIGKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKSKTKLEQQVDDLEGSLEQEKKLR 1047
Cdd:TIGR00618  289 aRKAAPLAAHIKAvtqieqQAQRIHTELQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIR 368
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1048 MDLERAKRKLEGDLKLAQesimDLENDKQQSEEKLKKKDFETSQ------LLSKIEDEQSLGAQLQKKIKELQARIEELE 1121
Cdd:TIGR00618  369 EISCQQHTLTQHIHTLQQ----QKTTLTQKLQSLCKELDILQREqatidtRTSAFRDLQGQLAHAKKQQELQQRYAELCA 444
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1122 EEIEAERAARAKVEKQRADLSRELEEISERLEEAGGATAAQIEMNKKREA---EFQKLRRDLEESTLQHEATAAALRKKQ 1198
Cdd:TIGR00618  445 AAITCTAQCEKLEKIHLQESAQSLKEREQQLQTKEQIHLQETRKKAVVLArllELQEEPCPLCGSCIHPNPARQDIDNPG 524
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1199 ADS---------VAELGEQIDNLQRVKQKLEKEKSEYKMEIDDLSSNMEAVAKAKANLEKMCRTLEDQLSEIKSKNDENL 1269
Cdd:TIGR00618  525 PLTrrmqrgeqtYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQDLTEKLS 604
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1270 RqindlsaQRARLQTENGEFGRQLEEKEALVS-QLTRGKQAFTQQIEELKRQIEEEVKAKNALAHAVQSARHDCDLLREQ 1348
Cdd:TIGR00618  605 E-------AEDMLACEQHALLRKLQPEQDLQDvRLHLQQCSQELALKLTALHALQLTLTQERVREHALSIRVLPKELLAS 677
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1349 FEEEQEAKAELQRGMSKANSEVAQWRTKyetdaiqrTEELEESKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQGEVE 1428
Cdd:TIGR00618  678 RQLALQKMQSEKEQLTYWKEMLAQCQTL--------LRELETHIEEYDREFNEIENASSSLGSDLAAREDALNQSLKELM 749
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1429 DlmidvERANALAANLDKKQRNFDKVLAEWK--QKYEEGQAELEGAQKEARSLSTELFKMKNSYEETLD--------QLE 1498
Cdd:TIGR00618  750 H-----QARTVLKARTEAHFNNNEEVTAALQtgAELSHLAAEIQFFNRLREEDTHLLKTLEAEIGQEIPsdedilnlQCE 824
                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 288856329  1499 TLKRENKNLQQEISDLTEQLGETGKSIHELEKSKKAVET---EKAEIQTALEEAEG 1551
Cdd:TIGR00618  825 TLVQEEEQFLSRLEEKSATLGEITHQLLKYEECSKQLAQltqEQAKIIQLSDKLNG 880
PTZ00121 PTZ00121
MAEBL; Provisional
832-1513 3.59e-16

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 85.58  E-value: 3.59e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  832 MKVYYKIKPLLKSAETEKELATMKEDFVKCKEDLAKAEAKKKELEEKMVALLQEKNDLQLAVASESENLSDAeerceglI 911
Cdd:PTZ00121 1262 MAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADA-------A 1334
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  912 KSKIQLEAKLKETTERLEDEEEINAELTAKKRKL-EDECSELKKDIDDLEltlAKVEKEKHATENKVKnlTEEMAAQDES 990
Cdd:PTZ00121 1335 KKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAaEKKKEEAKKKADAAK---KKAEEKKKADEAKKK--AEEDKKKADE 1409
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  991 IGKLTKEKKALQEAHQqtlddlQAEEDKVNTLTKSKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGD-LKLAQESIM 1069
Cdd:PTZ00121 1410 LKKAAAAKKKADEAKK------KAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADeAKKKAEEAK 1483
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1070 DLENDKQQSEEKLKKKDFETSQLLSKIEDEQSLGAQLQKKIKELQARIeeleeeieaeraarakvEKQRADLSRELEEIs 1149
Cdd:PTZ00121 1484 KADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAE-----------------EAKKADEAKKAEEK- 1545
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1150 ERLEEAGGATaaqiEMNKKREAEFQKLRRDLEESTLQHEATAAALRKKQADSVAELGEQIDNLQRVKQKLEKEKSEYKME 1229
Cdd:PTZ00121 1546 KKADELKKAE----ELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIK 1621
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1230 IDDLSSNmEAVAKAKANLEKMCRTLEDQLSEIKSKNDENLRQINDLsAQRARLQTENGEFGRQLEEKEALVSQLTRGKQA 1309
Cdd:PTZ00121 1622 AEELKKA-EEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEE-AKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAE 1699
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1310 FTQQIEELKRQIEEEVKAKNALAHAVQSARHDCDLLREQfEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEEL- 1388
Cdd:PTZ00121 1700 EAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKE-AEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKe 1778
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1389 ----EESKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQGEVEDLMIDVERANALAANLDKKQRNFDKVLAewKQKYEE 1464
Cdd:PTZ00121 1779 avieEELDEEDEKRRMEVDKKIKDIFDNFANIIEGGKEGNLVINDSKEMEDSAIKEVADSKNMQLEEADAFE--KHKFNK 1856
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*....
gi 288856329 1465 GQAELEGAQKEARSlSTELFKMKNSYEETLDQLETLKRENKNLQQEISD 1513
Cdd:PTZ00121 1857 NNENGEDGNKEADF-NKEKDLKEDDEEEIEEADEIEKIDKDDIEREIPN 1904
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1445-1926 4.04e-16

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 84.71  E-value: 4.04e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1445 DKKQRNFDKVLAEWKQKYEEGQAELE--GAQKE-ARSLSTELFKMKNSYEETLDQLETLKrenknlqQEISDLTEQLGET 1521
Cdd:PRK02224  198 EKEEKDLHERLNGLESELAELDEEIEryEEQREqARETRDEADEVLEEHEERREELETLE-------AEIEDLRETIAET 270
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1522 GKsihELEKSKKAVETEKAEIQTALEEAEGTLEH------EESKILRVQLELNQVKSEIDRKLAEKDEEIEQIKRNSQRI 1595
Cdd:PRK02224  271 ER---EREELAEEVRDLRERLEELEEERDDLLAEaglddaDAEAVEARREELEDRDEELRDRLEECRVAAQAHNEEAESL 347
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1596 TDSMQstldsEVRSRNDALRIK-KKMEGDLNEMEIQLSHANRQAAEAQKQLRNVQAQLKDAQLHLDDAVRGQEDMKEQVA 1674
Cdd:PRK02224  348 REDAD-----DLEERAEELREEaAELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERD 422
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1675 MVERRNTLMQSEIEELRAALEQTER----------GRKVAEQELVDASERVGllhsqntsllNTKKKLEADLVQIQSEVE 1744
Cdd:PRK02224  423 ELREREAELEATLRTARERVEEAEAlleagkcpecGQPVEGSPHVETIEEDR----------ERVEELEAELEDLEEEVE 492
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1745 DTvqEARNAEdkakkaitdaammAEELKKEQDTSAHLERMKKNLEVTVKDLQHRLDEAEnlamkggkKQLQKLESRVREL 1824
Cdd:PRK02224  493 EV--EERLER-------------AEDLVEAEDRIERLEERREDLEELIAERRETIEEKR--------ERAEELRERAAEL 549
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1825 ESEVEAEQRRGADAVKGVRKYERRVKELTYQTEEDKKNVNRLQDLVDKLQLKVKAYKRQSE---------EAEEQANSHL 1895
Cdd:PRK02224  550 EAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERIESLERIRTLLAAIADAEDEIERlrekrealaELNDERRERL 629
                         490       500       510
                  ....*....|....*....|....*....|.
gi 288856329 1896 SKLRKVQHELEEAEERADIAESQVNKLRAKS 1926
Cdd:PRK02224  630 AEKRERKRELEAEFDEARIEEAREDKERAEE 660
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
917-1588 5.51e-16

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 83.92  E-value: 5.51e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   917 LEAKLKETTERLEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATE-------NKVKNLTEEMAAQDE 989
Cdd:TIGR04523   80 LEQQIKDLNDKLKKNKDKINKLNSDLSKINSEIKNDKEQKNKLEVELNKLEKQKKENKknidkflTEIKKKEKELEKLNN 159
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   990 SIGKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKSKTKLEQQVDDLEGSLEQEKKLRMDLErakrKLEGDLKLAQESIM 1069
Cdd:TIGR04523  160 KYNDLKKQKEELENELNLLEKEKLNIQKNIDKIKNKLLKLELLLSNLKKKIQKNKSLESQIS----ELKKQNNQLKDNIE 235
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1070 DLENDKQQSEEKLKKKDFETSQLLSKIEDEQSlgaQLQKKIKELQARIEELEEEIEAERAARAKVE----KQRADLSREL 1145
Cdd:TIGR04523  236 KKQQEINEKTTEISNTQTQLNQLKDEQNKIKK---QLSEKQKELEQNNKKIKELEKQLNQLKSEISdlnnQKEQDWNKEL 312
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1146 EEISERLEEAGGATAAQIEMNKKREAEF----QKLRRDLEESTLQHEataaalrkkqadsvaELGEQIDNLQRVKQKLEK 1221
Cdd:TIGR04523  313 KSELKNQEKKLEEIQNQISQNNKIISQLneqiSQLKKELTNSESENS---------------EKQRELEEKQNEIEKLKK 377
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1222 EKSEYKMEIDDLSSNMEAVAKAKANLEKMCRTLEDQLSEIKSKNDENLRQINDLSAQRARLQTENGEFGRQLEEKEALVS 1301
Cdd:TIGR04523  378 ENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIK 457
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1302 QLTRGKQAFTQQIEELKRQIEEEVKAKNALAHAVQSARHDCDLLREQFEEEQEAKAELQRGMSKANSEVaqwrtkyetda 1381
Cdd:TIGR04523  458 NLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKI----------- 526
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1382 iqrtEELEESKKKLAQRLQEAEEQIEAVNS--KCASLEKTKQRLQGEVEDLMIDVEranalaaNLDKKQRNFDKVLAEWK 1459
Cdd:TIGR04523  527 ----EKLESEKKEKESKISDLEDELNKDDFelKKENLEKEIDEKNKEIEELKQTQK-------SLKKKQEEKQELIDQKE 595
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1460 QKYEEGQAELEGAQKEARSLSTELFKMKNSYEETLDQLETLKRENKNLQQEISDLTEQLGETGKSIHELEKSKKAVETEK 1539
Cdd:TIGR04523  596 KEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLKQEVKQIKETIKEIRNKWPEIIKKIKESKTKI 675
                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|
gi 288856329  1540 AE-IQTALEEAEGTLEHEESKIlrvqleLNQVKSEIDRKLAEKDEEIEQI 1588
Cdd:TIGR04523  676 DDiIELMKDWLKELSLHYKKYI------TRMIRIKDLPKLEEKYKEIEKE 719
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
1210-1905 6.37e-16

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 84.25  E-value: 6.37e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1210 DNLQRVKQKLEKEKSEYKMEIDDLSSNMEAVAKAKANLEKMCRTLEDQLSEIKsKNDENLRQINDLSAQRARLQTENGEF 1289
Cdd:TIGR00618  187 AKKKSLHGKAELLTLRSQLLTLCTPCMPDTYHERKQVLEKELKHLREALQQTQ-QSHAYLTQKREAQEEQLKKQQLLKQL 265
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1290 GRQLEEKEALVSQLtrgkqAFTQQIEELKRQIEEEVKAKNALAHAVQSArhdcdllreqfeeeQEAKAELQRGMSKANSE 1369
Cdd:TIGR00618  266 RARIEELRAQEAVL-----EETQERINRARKAAPLAAHIKAVTQIEQQA--------------QRIHTELQSKMRSRAKL 326
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1370 VAQWRtkyetdAIQRTEELEESKKKLAQRLQEAEEQIEAVNSKCASLEKTK-------QRLQGEVEDLMIDVERANALAA 1442
Cdd:TIGR00618  327 LMKRA------AHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREIScqqhtltQHIHTLQQQKTTLTQKLQSLCK 400
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1443 NLDKKQRNFDKVLAEwKQKYEEGQAELEGAQKEARSLSTELFKMKNSYEETLDQLETLKRENKNLQQEISDLTEQLGeTG 1522
Cdd:TIGR00618  401 ELDILQREQATIDTR-TSAFRDLQGQLAHAKKQQELQQRYAELCAAAITCTAQCEKLEKIHLQESAQSLKEREQQLQ-TK 478
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1523 KSIHELEKSKKAVETEKAEIQTALE-EAEGTLEHEE-------------SKILRVQLELNQVKSEIDRKLAEKDEEIEQI 1588
Cdd:TIGR00618  479 EQIHLQETRKKAVVLARLLELQEEPcPLCGSCIHPNparqdidnpgpltRRMQRGEQTYAQLETSEEDVYHQLTSERKQR 558
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1589 KRNSQRITDSMQSTLDSEV---RSRNDALRIKKKMEGDLNEMEIQLSHANRQAAEAQKQLRNVQAQLKDAQLHLDDAVRG 1665
Cdd:TIGR00618  559 ASLKEQMQEIQQSFSILTQcdnRSKEDIPNLQNITVRLQDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHLQQCS 638
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1666 QEDMKEQVAMVERRNTLMQSEIEELRAALEQTERGRKVAEQELVDASErvgllhSQNTSLLNTKKKLEadlvQIQSeved 1745
Cdd:TIGR00618  639 QELALKLTALHALQLTLTQERVREHALSIRVLPKELLASRQLALQKMQ------SEKEQLTYWKEMLA----QCQT---- 704
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1746 tvqearnaedkakkaitdaaMMAEELKKEQDTSAHLERMKKNLEVTVKDLQHRLD---EAENLAMKGGKKQLQKLESRVR 1822
Cdd:TIGR00618  705 --------------------LLRELETHIEEYDREFNEIENASSSLGSDLAAREDalnQSLKELMHQARTVLKARTEAHF 764
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1823 ELESEVEAEQRRGADAVKGVRKYERRVKELTYQTEEDKKNVNRLQDLVDKLQLKVKAYKRQSEEAEEQANSHLSKLRKVQ 1902
Cdd:TIGR00618  765 NNNEEVTAALQTGAELSHLAAEIQFFNRLREEDTHLLKTLEAEIGQEIPSDEDILNLQCETLVQEEEQFLSRLEEKSATL 844

                   ...
gi 288856329  1903 HEL 1905
Cdd:TIGR00618  845 GEI 847
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
880-1274 1.51e-15

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 83.18  E-value: 1.51e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   880 VALLQEK-NDLQLAVASESENLSDAEERCEGLIKSKIQLEAKLKETTERLEDEEEINAELTAKKRKLEDECSELKKDIDD 958
Cdd:TIGR02168  686 IEELEEKiAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEE 765
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   959 LELTLAKVEKEKHATENKVKNLTEEMAAQDESIGKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKSKTKLEQQVDDLEG 1038
Cdd:TIGR02168  766 LEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEE 845
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1039 SLEQEKKLRMDLERAKRKLEGDLKLAQESIMDLENDKQQSEEKLKKKDFETSQLLSKIEDEQSLGAQLQKKIKELQARie 1118
Cdd:TIGR02168  846 QIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREK-- 923
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1119 eleeeieaeraaRAKVEKQRADLSRELEEISERLEEAGGATA-AQIEMNKKREAEFQKLRRdleestlqheataaalrkk 1197
Cdd:TIGR02168  924 ------------LAQLELRLEGLEVRIDNLQERLSEEYSLTLeEAEALENKIEDDEEEARR------------------- 972
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 288856329  1198 qadSVAELGEQIDNLQRVKQKLEKEKSEYKMEIDDLSSNMEAVAKAKANLEKmcrTLEDQLSEIKSKNDENLRQIND 1274
Cdd:TIGR02168  973 ---RLKRLENKIKELGPVNLAAIEEYEELKERYDFLTAQKEDLTEAKETLEE---AIEEIDREARERFKDTFDQVNE 1043
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
918-1784 1.98e-15

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 82.71  E-value: 1.98e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   918 EAKLKETTERL-----EDEEEINAEL-TAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAAQDEsi 991
Cdd:pfam02463  175 LKKLIEETENLaeliiDLEELKLQELkLKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQELLRDEQEE-- 252
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   992 gklTKEKKALQEAHQQTLDDLQAEEDKVNTLTKSKTKLEQQVDDLEGSLEQEK-KLRMDLERAKRKLEGDLKLAQESIMD 1070
Cdd:pfam02463  253 ---IESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELlKLERRKVDDEEKLKESEKEKKKAEKE 329
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1071 LENDKQQSEEKLKKKDFETSQLLSKIEDEQSLGAQLQKKIKELQARIEELEEEIEAERAARAKVEKQRADLSRELEEISE 1150
Cdd:pfam02463  330 LKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQL 409
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1151 RLEeaggataaqIEMNKKREAEFQKLRRDLEESTLQHEATAaalrkkqadsvAELGEQIDNLQRVKQKLEKEKSEYKMEI 1230
Cdd:pfam02463  410 LLE---------LARQLEDLLKEEKKEELEILEEEEESIEL-----------KQGKLTEEKEELEKQELKLLKDELELKK 469
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1231 DDLSSNMEAVAKAKANLEKMCRTLEDQLSEIKSKNDENLRQINDLSAQRARLQTENGEFGRQLEEKEALVSQLTRGKQAF 1310
Cdd:pfam02463  470 SEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAV 549
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1311 TQQIEELKRQIEEEVKAKNAL----------AHAVQSARHDCDLLREQFEEEQEAKAELQRGMSKANSEVAQWRTKYETD 1380
Cdd:pfam02463  550 IVEVSATADEVEERQKLVRALtelplgarklRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKVVEGIL 629
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1381 AIQRTEELEESKKKLAQRLQEAEEQIEAVNSKC---ASLEKTKQRLQGEVEDLMID--VERANALAANLDKKQRNFDKVL 1455
Cdd:pfam02463  630 KDTELTKLKESAKAKESGLRKGVSLEEGLAEKSevkASLSELTKELLEIQELQEKAesELAKEEILRRQLEIKKKEQREK 709
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1456 AEWKQKYEEGQAELEGAQKEARSLSTELFKMKNSyEETLDQLETLKRENKNLQQEISDLTEQLGETGKSIHELEKSKKAV 1535
Cdd:pfam02463  710 EELKKLKLEAEELLADRVQEAQDKINEELKLLKQ-KIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKV 788
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1536 ETEKAEIQTALEEAegtlehEESKILRVQLELNQVKSEIDRKLAEKDEEIEQIKRNSQRITDSMQSTLDSEVRSRNDALR 1615
Cdd:pfam02463  789 EEEKEEKLKAQEEE------LRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEE 862
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1616 IKKK--------MEGDLNEMEIQLSHANRQAAEAQKQLRNVQAQLKDAQLHlDDAVRGQEDMKEQVAMVERRNTLMQSEI 1687
Cdd:pfam02463  863 ITKEellqelllKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLE-EKENEIEERIKEEAEILLKYEEEPEELL 941
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1688 EELRAALEQTERGRKVAEQELVDASERVGLLHSQNTSLLNTKKKLEADLVQIQSEVEDTVQEarNAEDKAKKAITDAAMM 1767
Cdd:pfam02463  942 LEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKERLEEE--KKKLIRAIIEETCQRL 1019
                          890
                   ....*....|....*..
gi 288856329  1768 AEELKKEQDTSAHLERM 1784
Cdd:pfam02463 1020 KEFLELFVSINKGWNKV 1036
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
885-1430 2.28e-15

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 82.40  E-value: 2.28e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  885 EKNDLQLAVASESENLSDAEERCEGLIKSKIQLEAKLKETTERLEDEEEINAELTakkrkledecsELKKDIDDLELTLA 964
Cdd:PRK02224  200 EEKDLHERLNGLESELAELDEEIERYEEQREQARETRDEADEVLEEHEERREELE-----------TLEAEIEDLRETIA 268
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  965 KVEKEKHAtenkvknLTEEMAAQDESIGKLTKEKKALQEahQQTLDDLQAE--EDKVNTLTKSKTKLEQQVDDLEGSLEQ 1042
Cdd:PRK02224  269 ETEREREE-------LAEEVRDLRERLEELEEERDDLLA--EAGLDDADAEavEARREELEDRDEELRDRLEECRVAAQA 339
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1043 EKKLRMDLERAKRKLEGDLKLAQESIMDLENDKQQSEEKLKKKDFETSQLLSKIEDeqslgaqLQKKIKELQARIEELEE 1122
Cdd:PRK02224  340 HNEEAESLREDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEE-------LRERFGDAPVDLGNAED 412
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1123 EIEAERAARAKVEKQRADLSRELEEISERLEEAGGATAA--------------QIEMNKKREAEFQKLRRDLEESTLQHE 1188
Cdd:PRK02224  413 FLEELREERDELREREAELEATLRTARERVEEAEALLEAgkcpecgqpvegspHVETIEEDRERVEELEAELEDLEEEVE 492
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1189 ATAAALrkKQADSVAELGEQIDNLQRVKQKLEKEKSEYKMEIDDLSSNMEAVAKAKANLEKMCRTLEDQLSEIKSKNDEN 1268
Cdd:PRK02224  493 EVEERL--ERAEDLVEAEDRIERLEERREDLEELIAERRETIEEKRERAEELRERAAELEAEAEEKREAAAEAEEEAEEA 570
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1269 LRQINDLSAQRARLQTEngefgrqLEEKEALVSQLTRgkqaftqqIEELKRQIEEEVKAKNALAHAVqsarhdcDLLREQ 1348
Cdd:PRK02224  571 REEVAELNSKLAELKER-------IESLERIRTLLAA--------IADAEDEIERLREKREALAELN-------DERRER 628
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1349 FEEEQEAKAELQRGMSKANSEVAQWR----TKYETDAIQRTEELEESKKKLAQRLQEAEEQIEAVNS---KCASLEKTKQ 1421
Cdd:PRK02224  629 LAEKRERKRELEAEFDEARIEEAREDkeraEEYLEQVEEKLDELREERDDLQAEIGAVENELEELEElreRREALENRVE 708
                         570
                  ....*....|..
gi 288856329 1422 RLQ---GEVEDL 1430
Cdd:PRK02224  709 ALEalyDEAEEL 720
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
1075-1928 2.97e-15

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 81.94  E-value: 2.97e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1075 KQQSEEKLKKKDFETSQLLSK-------IEDEQSLGAQLQKKIKELQARIEELEEEIEAERAARAKVEKQRADLSRELEE 1147
Cdd:pfam02463  168 KRKKKEALKKLIEETENLAELiidleelKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQELLR 247
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1148 ISERLEEAGGATAAQIEMNKKREAEFQKLrrDLEESTLQHEataaaLRKKQADSVAELGEQIDNLQRVKQKLEKEKSEYK 1227
Cdd:pfam02463  248 DEQEEIESSKQEIEKEEEKLAQVLKENKE--EEKEKKLQEE-----ELKLLAKEEEELKSELLKLERRKVDDEEKLKESE 320
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1228 MEIDDLSSNMEAVAKAKANLEKMCRTLEDQLSEIKSKNDENLRQINDLSAQRARLQTENGE----FGRQLEEKEALVSQL 1303
Cdd:pfam02463  321 KEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLeserLSSAAKLKEEELELK 400
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1304 TRGKQAFTQQIEELKRQIEEEVKAKNALAHAVQSARHDCDLLREQFEEEQEAKaELQRGMSKANSEVAqwrtKYETDAIQ 1383
Cdd:pfam02463  401 SEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEEL-EKQELKLLKDELEL----KKSEDLLK 475
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1384 RTEELEESKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQGEVEDLMIDVERANALAANLDKKQRNFDKVLAEWKQKYE 1463
Cdd:pfam02463  476 ETQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEVSA 555
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1464 EGQAELEGAQKEARSLSTELFKMKNSYEETLDQLE---TLKRENKNLQQEISDLTEQLGETGKSIHELEKSKKAVETEKA 1540
Cdd:pfam02463  556 TADEVEERQKLVRALTELPLGARKLRLLIPKLKLPlksIAVLEIDPILNLAQLDKATLEADEDDKRAKVVEGILKDTELT 635
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1541 EIQTALEEAEGTLEH--EESKILRVQLELNQVKSEIDRKLAEKDEEIEQIKRNSQRITDSMQSTLDSEVRSRNDALRIKK 1618
Cdd:pfam02463  636 KLKESAKAKESGLRKgvSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKKL 715
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1619 KMEGDLNEMEIQLSHANRQAAEAQKQLRNVQAQLKDAQLHLDDAVRGQEDMKEQVAMvERRNTLMQSEIEELRAALEQTE 1698
Cdd:pfam02463  716 KLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLK-EKELAEEREKTEKLKVEEEKEE 794
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1699 RgRKVAEQELVDASERVGLLHSQNTSLLNTKKKLEADLVQIQSEVEDTVQEARNAEDKAKKAITDAAMMAEELKKEQDTS 1778
Cdd:pfam02463  795 K-LKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITKEELLQELL 873
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1779 AHLERMKKNLEVTVKDLQHRLDEAENLAMKGGKKQLQKLESRVRELESEVEAEQrrgadavKGVRKYERRVKELtyqTEE 1858
Cdd:pfam02463  874 LKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEA-------EILLKYEEEPEEL---LLE 943
                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1859 DKKNVNRLQDLVDKLQLKVKAYKRQSEEAEEQANSHLSklrkvqhELEEAEERADIAESQVNKLRAKSRD 1928
Cdd:pfam02463  944 EADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAIE-------EFEEKEERYNKDELEKERLEEEKKK 1006
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1292-1826 3.38e-15

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 81.62  E-value: 3.38e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1292 QLEEKEA--LVSQLTRGKQAFTQQIEELKRQIEEEVKAKnalahavqSARHDCDLLREQFEEEQEAKAELQRGMSKANSE 1369
Cdd:PRK02224  195 QIEEKEEkdLHERLNGLESELAELDEEIERYEEQREQAR--------ETRDEADEVLEEHEERREELETLEAEIEDLRET 266
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1370 VAQWRTKYET------DAIQRTEELEESKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQGEVEDLMIDVERANALAAN 1443
Cdd:PRK02224  267 IAETEREREElaeevrDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDRLEECRVAAQAHNEEAES 346
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1444 LDKKQRNFDKVLAEWKQKYEEGQAELEGAQKEARSLSTELFKMKNSYEE-------TLDQLETLKRENKNLQQEISDLTE 1516
Cdd:PRK02224  347 LREDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEElrerfgdAPVDLGNAEDFLEELREERDELRE 426
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1517 QLGETGKSIHELEKSKKAVET--------------EKAEIQTALEEAEGTLEHEESKILRVQLELNQVKSEIDR--KLAE 1580
Cdd:PRK02224  427 REAELEATLRTARERVEEAEAlleagkcpecgqpvEGSPHVETIEEDRERVEELEAELEDLEEEVEEVEERLERaeDLVE 506
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1581 KDEEIEQIKRNSQRITDSMqSTLDSEVRSRNDALRIKKKMEGDLN-EMEIQLSHANRQAAEAQKQLRNVqAQLKDAQLHL 1659
Cdd:PRK02224  507 AEDRIERLEERREDLEELI-AERRETIEEKRERAEELRERAAELEaEAEEKREAAAEAEEEAEEAREEV-AELNSKLAEL 584
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1660 DDAVRGQEDMKEQVAMVERrntlMQSEIEELRAALEQ-TERGRKVAEQeLVDASERvgllhsqntsllntKKKLEADLvq 1738
Cdd:PRK02224  585 KERIESLERIRTLLAAIAD----AEDEIERLREKREAlAELNDERRER-LAEKRER--------------KRELEAEF-- 643
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1739 iqseVEDTVQEARNAEDKAKKAITDAAMMAEELKKEQDtsahlermkkNLEVTVKDLQHRLDEAENLamkggKKQLQKLE 1818
Cdd:PRK02224  644 ----DEARIEEAREDKERAEEYLEQVEEKLDELREERD----------DLQAEIGAVENELEELEEL-----RERREALE 704

                  ....*...
gi 288856329 1819 SRVRELES 1826
Cdd:PRK02224  705 NRVEALEA 712
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1035-1654 6.18e-15

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 81.11  E-value: 6.18e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1035 DLEGSLEQEKKLRMDLERAKRKLEgdlkLAQESIMDLE--NDKQQSEEKLKKKDFETSQLLSKIEDEQSlgaqlQKKIKE 1112
Cdd:COG4913   222 DTFEAADALVEHFDDLERAHEALE----DAREQIELLEpiRELAERYAAARERLAELEYLRAALRLWFA-----QRRLEL 292
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1113 LQARIEELEEEIEAERAARAKVEKQRADLSRELEEISERLEEAGGATAAQIEmnkKREAEFQKLRRDLEESTLQHEATAA 1192
Cdd:COG4913   293 LEAELEELRAELARLEAELERLEARLDALREELDELEAQIRGNGGDRLEQLE---REIERLERELEERERRRARLEALLA 369
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1193 ALRKKQADSVAELGEQIDNLQRVKQKLEKEKSEYKMEIDDLssnmeAVAKAKANLEKmcRTLEDQLSEIKSKN---DENL 1269
Cdd:COG4913   370 ALGLPLPASAEEFAALRAEAAALLEALEEELEALEEALAEA-----EAALRDLRREL--RELEAEIASLERRKsniPARL 442
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1270 RQINDLSAQRARLQTEN----GE---------------------FGRQL---EEKEALVSQL---TRGKQAF-TQQIEEL 1317
Cdd:COG4913   443 LALRDALAEALGLDEAElpfvGElievrpeeerwrgaiervlggFALTLlvpPEHYAAALRWvnrLHLRGRLvYERVRTG 522
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1318 KRQIEEEVKAKNALAHAVQSARHDC-----DLLREQF-------EEE--QEAKAELQRGMSKANsevaqwRTKYETDAiq 1383
Cdd:COG4913   523 LPDPERPRLDPDSLAGKLDFKPHPFrawleAELGRRFdyvcvdsPEElrRHPRAITRAGQVKGN------GTRHEKDD-- 594
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1384 rteeleesKKKLAQRL---QEAEEQIEAvnskcasLEKTKQRLQGEVEDLMIDVERANALAANLDKKQRNFDKVlaewkQ 1460
Cdd:COG4913   595 --------RRRIRSRYvlgFDNRAKLAA-------LEAELAELEEELAEAEERLEALEAELDALQERREALQRL-----A 654
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1461 KYEEGQAELEGAQKEARSLSTELFKMknsyEETLDQLETLKRENKNLQQEISDLTEQLGETGKSIHELEKSKKAVETEKA 1540
Cdd:COG4913   655 EYSWDEIDVASAEREIAELEAELERL----DASSDDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELD 730
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1541 EIQTALEEAEGTLEHEESKIL---RVQLELNQVKSEIDRKLAEK-DEEIEQIKRNSQRITDSMQ----------STLDSE 1606
Cdd:COG4913   731 ELQDRLEAAEDLARLELRALLeerFAAALGDAVERELRENLEERiDALRARLNRAEEELERAMRafnrewpaetADLDAD 810
                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 288856329 1607 VRSRNDALRIKKKMEGD------------LNEMEIQ-----LSHANRQAAEAQKQLRNVQAQLKD 1654
Cdd:COG4913   811 LESLPEYLALLDRLEEDglpeyeerfkelLNENSIEfvadlLSKLRRAIREIKERIDPLNDSLKR 875
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
906-1655 6.42e-15

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 80.78  E-value: 6.42e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   906 RCEGLIKSKIQLEAKLKETTERLEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT----ENKVKNLT 981
Cdd:TIGR00618  153 EFAQFLKAKSKEKKELLMNLFPLDQYTQLALMEFAKKKSLHGKAELLTLRSQLLTLCTPCMPDTYHERkqvlEKELKHLR 232
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   982 EEMAAQDESIGKLTKEKKALQEAH--QQTLDDLQAEEDKVNTLTKSKTKLEQQVDdlegslEQEKKLRMDLErakrkleg 1059
Cdd:TIGR00618  233 EALQQTQQSHAYLTQKREAQEEQLkkQQLLKQLRARIEELRAQEAVLEETQERIN------RARKAAPLAAH-------- 298
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1060 dlklaQESIMDLENDKQQSEEKLKKKDFETSQLLSKIEDEQSLGAQLQKKIKELQARIEELEEEIEAERAARAKvekqRA 1139
Cdd:TIGR00618  299 -----IKAVTQIEQQAQRIHTELQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSI----RE 369
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1140 DLSRELEeiserLEEAGGATAAQIEMNKKREAEFQKLRRDLEESTLQHEATAAALRKKQADSVAELGEQIDNLQRVKQKL 1219
Cdd:TIGR00618  370 ISCQQHT-----LTQHIHTLQQQKTTLTQKLQSLCKELDILQREQATIDTRTSAFRDLQGQLAHAKKQQELQQRYAELCA 444
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1220 EKEKSEYKMEIddlssnmeavaKAKANLEKMCRTLEDQlseiksknDENLRQINDLSAQRARLQTENGEFGRQLEEKEAL 1299
Cdd:TIGR00618  445 AAITCTAQCEK-----------LEKIHLQESAQSLKER--------EQQLQTKEQIHLQETRKKAVVLARLLELQEEPCP 505
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1300 VSQLTRGKQAFTQQIEE---LKRQIEEEVKAKNALAHAVQSARHDCDLLREQF----EEEQEAKAELQRGMSKAN--SEV 1370
Cdd:TIGR00618  506 LCGSCIHPNPARQDIDNpgpLTRRMQRGEQTYAQLETSEEDVYHQLTSERKQRaslkEQMQEIQQSFSILTQCDNrsKED 585
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1371 AQWRTKYETDAIQRTEELEESKKKLA--QRLQEAEEQIEAVNSKCA--------SLEKTKQRLQGEVEDLMIDVERANAL 1440
Cdd:TIGR00618  586 IPNLQNITVRLQDLTEKLSEAEDMLAceQHALLRKLQPEQDLQDVRlhlqqcsqELALKLTALHALQLTLTQERVREHAL 665
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1441 AANLDKKQrnfdkvlaewkqKYEEGQAELEGAQKEARSLSTELfKMKNSYEETLDQLETLKRENKNLQQEI--------S 1512
Cdd:TIGR00618  666 SIRVLPKE------------LLASRQLALQKMQSEKEQLTYWK-EMLAQCQTLLRELETHIEEYDREFNEIenassslgS 732
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1513 DLTEQLGETGKSIHELEKSKKAVETEKAEIQTALEEAEGTLEH---EESKILRVQLELNQVKSEIDRKLAEKDEEIEQIK 1589
Cdd:TIGR00618  733 DLAAREDALNQSLKELMHQARTVLKARTEAHFNNNEEVTAALQtgaELSHLAAEIQFFNRLREEDTHLLKTLEAEIGQEI 812
                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 288856329  1590 RNSQRITDSMQSTLDSEVRSRNDALRIKKKMEGDLNEMEIQLSHANRQAAEAQKQLRNVQAQLKDA 1655
Cdd:TIGR00618  813 PSDEDILNLQCETLVQEEEQFLSRLEEKSATLGEITHQLLKYEECSKQLAQLTQEQAKIIQLSDKL 878
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1374-1924 8.31e-15

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 80.49  E-value: 8.31e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1374 RTKYETDAIQRTEELEESKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQGEVEDLMIDVERANAL----------AAN 1443
Cdd:PRK03918  177 RIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEELKEEIEELekeleslegsKRK 256
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1444 LDKKQRNFDKVLAEWKQKYEEGQaELEGAQKEARSLSTELFKMKNSYEETLDQLETLKRENKNLQQEISDLTEQLGETGK 1523
Cdd:PRK03918  257 LEEKIRELEERIEELKKEIEELE-EKVKELKELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEE 335
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1524 SIHELEKSKKavetEKAEIQTALEEAEGTLEHEEsKILRVQLELNQVKSEIDRKLAEK-DEEIEQIKRNSQRITD----- 1597
Cdd:PRK03918  336 KEERLEELKK----KLKELEKRLEELEERHELYE-EAKAKKEELERLKKRLTGLTPEKlEKELEELEKAKEEIEEeiski 410
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1598 -SMQSTLDSEVRSRNDALRIKKKMEGD--LNEMEIQLSHANRQAAEAQKQLRNVQAQLKDAqlhlddavrgqEDMKEQVA 1674
Cdd:PRK03918  411 tARIGELKKEIKELKKAIEELKKAKGKcpVCGRELTEEHRKELLEEYTAELKRIEKELKEI-----------EEKERKLR 479
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1675 MVERrntlmqsEIEELRAALEQTERGRKVAEQelvdaservgllhsqntsLLNTKKKLEADLVQiqsEVEDTVQEARNAE 1754
Cdd:PRK03918  480 KELR-------ELEKVLKKESELIKLKELAEQ------------------LKELEEKLKKYNLE---ELEKKAEEYEKLK 531
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1755 DKAKKAITDAAMMAEELKKEQDtsahLERMKKNLEVTVKDLQHRLDEAENLAMKGGKKQLQKLESRVRELESEVEaEQRR 1834
Cdd:PRK03918  532 EKLIKLKGEIKSLKKELEKLEE----LKKKLAELEKKLDELEEELAELLKELEELGFESVEELEERLKELEPFYN-EYLE 606
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1835 GADAVKGVRKYERRVKELTYQTEEDKKNVNRLQDLVDKLQLKVKAYKRQ--SEEAEEQANSHLSK---LRKVQHELEEAE 1909
Cdd:PRK03918  607 LKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKysEEEYEELREEYLELsreLAGLRAELEELE 686
                         570
                  ....*....|....*
gi 288856329 1910 ERADIAESQVNKLRA 1924
Cdd:PRK03918  687 KRREEIKKTLEKLKE 701
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1200-1911 1.06e-14

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 80.34  E-value: 1.06e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1200 DSVAELGEQIDNLQRVKQKLEKEKSEYKM--EIDDLSSNMEAVAKAKANLEKMCRTLEDQLSEIKSknDENLRQINDLSA 1277
Cdd:COG4913   225 EAADALVEHFDDLERAHEALEDAREQIELlePIRELAERYAAARERLAELEYLRAALRLWFAQRRL--ELLEAELEELRA 302
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1278 QRARLQTENGEFGRQLEEKEALVSQLTRGKQAF-TQQIEELKRQIEEEVKAKNALAHAVQSARHDCDLLREQFEEEQEAK 1356
Cdd:COG4913   303 ELARLEAELERLEARLDALREELDELEAQIRGNgGDRLEQLEREIERLERELEERERRRARLEALLAALGLPLPASAEEF 382
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1357 AELQRgmskansEVAQWRTKYEtdaiQRTEELEESKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQGEVEDLmidveR 1436
Cdd:COG4913   383 AALRA-------EAAALLEALE----EELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNIPARLLAL-----R 446
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1437 AnALAANLDKKQRNFdKVLAEW---KQKYEEGQAELEGAqkeARSLSTELFKMKNSYEETLDQLETLKRenknlqqeisd 1513
Cdd:COG4913   447 D-ALAEALGLDEAEL-PFVGELievRPEEERWRGAIERV---LGGFALTLLVPPEHYAAALRWVNRLHL----------- 510
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1514 lteqlgetgksiheleksKKAVETEKAEiqTALEEAEGTLEHEESKILRVQLELNQVKSEIDRKLAEKD-----EEIEQI 1588
Cdd:COG4913   511 ------------------RGRLVYERVR--TGLPDPERPRLDPDSLAGKLDFKPHPFRAWLEAELGRRFdyvcvDSPEEL 570
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1589 KRNSQRITDSMQSTLDSEVRSRNDALRIKKK-------------MEGDLNEMEIQLSHANRQAAEAQKQLRNVQAQLkDA 1655
Cdd:COG4913   571 RRHPRAITRAGQVKGNGTRHEKDDRRRIRSRyvlgfdnraklaaLEAELAELEEELAEAEERLEALEAELDALQERR-EA 649
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1656 QLHLDDAVRGQEDMKEQVAMVERRntlmQSEIEELRAA---LEQTERGRKVAEQELVDASERVGLLHSQntsllntKKKL 1732
Cdd:COG4913   650 LQRLAEYSWDEIDVASAEREIAEL----EAELERLDASsddLAALEEQLEELEAELEELEEELDELKGE-------IGRL 718
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1733 EADLVQIQSEVEdtvQEARNAEDKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEVTVKDLQHRLDEAEnlamkggkk 1812
Cdd:COG4913   719 EKELEQAEEELD---ELQDRLEAAEDLARLELRALLEERFAAALGDAVERELRENLEERIDALRARLNRAE--------- 786
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1813 qlQKLESRVRELESEVEAEQRRGADAVKGVRKYERRVKELtyqtEEDkknvnrlqDLVDKLQlkvkAYKRQSEEAEEQAN 1892
Cdd:COG4913   787 --EELERAMRAFNREWPAETADLDADLESLPEYLALLDRL----EED--------GLPEYEE----RFKELLNENSIEFV 848
                         730
                  ....*....|....*....
gi 288856329 1893 SHLskLRKVQHELEEAEER 1911
Cdd:COG4913   849 ADL--LSKLRRAIREIKER 865
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
920-1490 1.27e-14

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 79.96  E-value: 1.27e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  920 KLKETTERLEDEEEINAELTAKKRKLEdecselKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAAQDESIGKLTKEKK 999
Cdd:COG4913   246 DAREQIELLEPIRELAERYAAARERLA------ELEYLRAALRLWFAQRRLELLEAELEELRAELARLEAELERLEARLD 319
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1000 ALQEahqqTLDDLQAEEDKVNTltKSKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKL-------EGDLKLAQESIMDLE 1072
Cdd:COG4913   320 ALRE----ELDELEAQIRGNGG--DRLEQLEREIERLERELEERERRRARLEALLAALglplpasAEEFAALRAEAAALL 393
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1073 NDKQQSEEKLKKKDFETSQLLSKIEDEQslgAQLQKKIKELqarieeleeeieaeraarakvEKQRADLSRELEEISERL 1152
Cdd:COG4913   394 EALEEELEALEEALAEAEAALRDLRREL---RELEAEIASL---------------------ERRKSNIPARLLALRDAL 449
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1153 EEAGGATAAQ-------IEMnKKREAEFQK--------LRRDL--EEstlQHEATAAA------LRKK-QADSVAELGEQ 1208
Cdd:COG4913   450 AEALGLDEAElpfvgelIEV-RPEEERWRGaiervlggFALTLlvPP---EHYAAALRwvnrlhLRGRlVYERVRTGLPD 525
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1209 IDNLQRVKQ----KLEKEKSEYKMEIDDLSSNMEAVAKAkANLEKMCR-----TLEDQLseiksKNDENLRQINDLSAQR 1279
Cdd:COG4913   526 PERPRLDPDslagKLDFKPHPFRAWLEAELGRRFDYVCV-DSPEELRRhpraiTRAGQV-----KGNGTRHEKDDRRRIR 599
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1280 ARLQtengeFG----RQLEEKEALVSQLTRGKQAFTQQIEELKRQIEEEVKAKNALAHAVQSARHDCDLLREQfEEEQEA 1355
Cdd:COG4913   600 SRYV-----LGfdnrAKLAALEAELAELEEELAEAEERLEALEAELDALQERREALQRLAEYSWDEIDVASAE-REIAEL 673
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1356 KAELQRgMSKANSEVaqwrtkyetdaiqrtEELEESKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQGEVEDLMIDVE 1435
Cdd:COG4913   674 EAELER-LDASSDDL---------------AALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLE 737
                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 288856329 1436 RANALA-----ANLDKK--QRNFDKVLAEWKQKYEEgqaELEGAQKEARSLSTELFKMKNSY 1490
Cdd:COG4913   738 AAEDLArlelrALLEERfaAALGDAVERELRENLEE---RIDALRARLNRAEEELERAMRAF 796
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
1187-1918 2.50e-14

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 79.11  E-value: 2.50e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1187 HEATAAALRKKQADSVAELGEQIDNLQRVKQKLEKEKSEYKMEIDDLSSNMEAVAKAKANLEKMCRTLEDQLSEiksKND 1266
Cdd:pfam12128  228 RDIQAIAGIMKIRPEFTKLQQEFNTLESAELRLSHLHFGYKSDETLIASRQEERQETSAELNQLLRTLDDQWKE---KRD 304
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1267 EnLRQinDLSAQRARLQTENgefgrqlEEKEALVSQLTRGKQAftqQIEELKRQIEEEVKAKNALAHavQSARHDCdLLR 1346
Cdd:pfam12128  305 E-LNG--ELSAADAAVAKDR-------SELEALEDQHGAFLDA---DIETAAADQEQLPSWQSELEN--LEERLKA-LTG 368
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1347 EQFEEEQEAKAELQRGMSKANSEVAqwRTKYETDAIQRTEE--LEESKKKLAQRLQEAEEQIEAVNskcASLEKTKQRLQ 1424
Cdd:pfam12128  369 KHQDVTAKYNRRRSKIKEQNNRDIA--GIKDKLAKIREARDrqLAVAEDDLQALESELREQLEAGK---LEFNEEEYRLK 443
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1425 GEVEDLMIDVERANAlAANLDKKQRNFDKVLaewkqkyEEGQAELEGAQKEARSLSTELFKMKNSYEETLDQLETLKREN 1504
Cdd:pfam12128  444 SRLGELKLRLNQATA-TPELLLQLENFDERI-------ERAREEQEAANAEVERLQSELRQARKRRDQASEALRQASRRL 515
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1505 KNLQQEISDLTEQLGETGKSIHELEKSkkavetekaeiqtaleEAEGTLEHEESKILRVQLELNQVKSEIDRKLAEKDEE 1584
Cdd:pfam12128  516 EERQSALDELELQLFPQAGTLLHFLRK----------------EAPDWEQSIGKVISPELLHRTDLDPEVWDGSVGGELN 579
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1585 IEQIKRNSQRITDSMQSTLDSEVRSRNDALrikkkmegdlnEMEIQLSHANRQAAEaqKQLRNVQAQLKDAQLHLDDAVR 1664
Cdd:pfam12128  580 LYGVKLDLKRIDVPEWAASEEELRERLDKA-----------EEALQSAREKQAAAE--EQLVQANGELEKASREETFART 646
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1665 GQEDMKEQvamVERRNTLMQSeieELRAALEQTERGRKVAEQELvdaservgllhsqnTSLLNTKKKLEADLVQIQSEVE 1744
Cdd:pfam12128  647 ALKNARLD---LRRLFDEKQS---EKDKKNKALAERKDSANERL--------------NSLEAQLKQLDKKHQAWLEEQK 706
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1745 DTVQEARNAEDKAKKAItdaammaeelkkEQDTSAHLERMKKNLEVTVKDLQHRLDEAE-----NLAMKGGKKQ-LQKLE 1818
Cdd:pfam12128  707 EQKREARTEKQAYWQVV------------EGALDAQLALLKAAIAARRSGAKAELKALEtwykrDLASLGVDPDvIAKLK 774
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1819 SRVRELESEVEAEQRRGADavkgVRKYERRVKE--------LTYQTEEDKKNVNRLQDLVDKLQLKVKAYKRQ------- 1883
Cdd:pfam12128  775 REIRTLERKIERIAVRRQE----VLRYFDWYQEtwlqrrprLATQLSNIERAISELQQQLARLIADTKLRRAKlemerka 850
                          730       740       750
                   ....*....|....*....|....*....|....*
gi 288856329  1884 SEEAEEQANSHLSKLRKVQHELEEAEERADIAESQ 1918
Cdd:pfam12128  851 SEKQQVRLSENLRGLRCEMSKLATLKEDANSEQAQ 885
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1145-1595 1.54e-13

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 75.96  E-value: 1.54e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1145 LEEISERLEEAGGATAAQIEMNKKreaEFQKLRRDLEESTLQHEATAAALRKKQadsvaELGEQIDNLQRVKQKLEKEKS 1224
Cdd:COG4717    48 LERLEKEADELFKPQGRKPELNLK---ELKELEEELKEAEEKEEEYAELQEELE-----ELEEELEELEAELEELREELE 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1225 EYKMEIdDLSSNMEAVAKAKANLEkmcrTLEDQLSEIKSKndenLRQINDLSAQRARLQTENGEFGRQLEEKEALVSQLT 1304
Cdd:COG4717   120 KLEKLL-QLLPLYQELEALEAELA----ELPERLEELEER----LEELRELEEELEELEAELAELQEELEELLEQLSLAT 190
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1305 RGK-QAFTQQIEELKRQIEEEVKAKNALAHAVQSARHDCDLLREQFEEEQEAKaELQRGMSKANSEVAQWRTKYETDAIQ 1383
Cdd:COG4717   191 EEElQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEE-RLKEARLLLLIAAALLALLGLGGSLL 269
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1384 RTEE------------LEESKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQGEVEDLMIDVERANALAANLDKKQRNF 1451
Cdd:COG4717   270 SLILtiagvlflvlglLALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEEL 349
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1452 DKVLAEWKQkyEEGQAELEGAQKEARSLsteLFKMKNSYEETLDQLETLKRENKNLQQEISDLTEQLGETGKSIHELEK- 1530
Cdd:COG4717   350 QELLREAEE--LEEELQLEELEQEIAAL---LAEAGVEDEEELRAALEQAEEYQELKEELEELEEQLEELLGELEELLEa 424
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 288856329 1531 -SKKAVETEKAEIQTALEEAEGTLEHEESKILRVQLELNQVKS--EIDRKLAEKDEEIEQIKRNSQRI 1595
Cdd:COG4717   425 lDEEELEEELEELEEELEELEEELEELREELAELEAELEQLEEdgELAELLQELEELKAELRELAEEW 492
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
908-1628 1.66e-13

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 75.91  E-value: 1.66e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   908 EGLIKSKIQLEAKLKETTERLEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAAQ 987
Cdd:pfam05483   88 EKIKKWKVSIEAELKQKENKLQENRKIIEAQRKAIQELQFENEKVSLKLEEEIQENKDLIKENNATRHLCNLLKETCARS 167
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   988 DESIGKLTKEKkalqEAHQQTLDDLQaeedkvNTLTKSKTKLEQqvddlegsleqekkLRMDLERAKRKLEGDLKLAQES 1067
Cdd:pfam05483  168 AEKTKKYEYER----EETRQVYMDLN------NNIEKMILAFEE--------------LRVQAENARLEMHFKLKEDHEK 223
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1068 IMDLEndkQQSEEKLKKKDFETSQLLSKIEDEQSLGAQLQKKIKELQARIEELEEEIEAERAARAKVEKQRADLSRELEE 1147
Cdd:pfam05483  224 IQHLE---EEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKANQLEEKTKLQDENLKELIEKKDHLTKELED 300
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1148 ISERLEEAggataaqIEMNKKREAEFQKLRRDLEESTLQHEATAAALRKKQADS---VAELGEQIDNLQRV----KQKLE 1220
Cdd:pfam05483  301 IKMSLQRS-------MSTQKALEEDLQIATKTICQLTEEKEAQMEELNKAKAAHsfvVTEFEATTCSLEELlrteQQRLE 373
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1221 KEKSEYK---MEIDDLSSNMEAVAKAKANLEKMCRTLEDQLSEIKSKNDENlRQINDLsAQRARLQTENGEFGRQLEEK- 1296
Cdd:pfam05483  374 KNEDQLKiitMELQKKSSELEEMTKFKNNKEVELEELKKILAEDEKLLDEK-KQFEKI-AEELKGKEQELIFLLQAREKe 451
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1297 ----EALVSQLTRGKQAFTQQIEELKRQIEEEvKAKNALAHAvqsarhDCDLLREQFEEEQEAKAELQRGMSKANSEVAQ 1372
Cdd:pfam05483  452 ihdlEIQLTAIKTSEEHYLKEVEDLKTELEKE-KLKNIELTA------HCDKLLLENKELTQEASDMTLELKKHQEDIIN 524
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1373 WRtKYETDAIQRTEELEESKKKLAQRLQ----EAEEQIEAVNSKCASLEKTKQRLQGEVEDLMIDVERANALAANLDKKQ 1448
Cdd:pfam05483  525 CK-KQEERMLKQIENLEEKEMNLRDELEsvreEFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKCNNLKKQI 603
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1449 RNfdkvlaewKQKYEEgqaELEGAQKEARSLSTELFKMKNSYEETLDQLETLKRENKNLQQEISDLTEQLGETgKSIHEl 1528
Cdd:pfam05483  604 EN--------KNKNIE---ELHQENKALKKKGSAENKQLNAYEIKVNKLELELASAKQKFEEIIDNYQKEIED-KKISE- 670
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1529 EKSKKAVETEKAEIQTALEEAEGTLEHEESKILRVQLELNQVKSEIDRKLAEKDEEIEQIKRNSQRiTDSMQSTLDSEVR 1608
Cdd:pfam05483  671 EKLLEEVEKAKAIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKNKEQE-QSSAKAALEIELS 749
                          730       740
                   ....*....|....*....|.
gi 288856329  1609 S-RNDALRIKKKMEGDLNEME 1628
Cdd:pfam05483  750 NiKAELLSLKKQLEIEKEEKE 770
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
895-1536 3.85e-13

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 75.10  E-value: 3.85e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  895 SESENLSDAEERCEGLIKSKIQ-LEAKLKETTERLEDEEEINAELtAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 973
Cdd:PRK03918  179 ERLEKFIKRTENIEELIKEKEKeLEEVLREINEISSELPELREEL-EKLEKEVKELEELKEEIEELEKELESLEGSKRKL 257
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  974 ENKVKNLTEEMAAQDESIGKLTKEKKALQEahqqtlddLQAEEDKVNTLTKSKTKLEQQVDDLEGSLEqekklrmdlera 1053
Cdd:PRK03918  258 EEKIRELEERIEELKKEIEELEEKVKELKE--------LKEKAEEYIKLSEFYEEYLDELREIEKRLS------------ 317
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1054 krKLEGDLKLAQESIMDLENDKQQSEEkLKKKDFETSQLLSKIEDEQSLGAQLQKKIKELQarieeleeeieaeraaraK 1133
Cdd:PRK03918  318 --RLEEEINGIEERIKELEEKEERLEE-LKKKLKELEKRLEELEERHELYEEAKAKKEELE------------------R 376
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1134 VEKQRADLsrELEEISERLEEAggataaqiemnKKREAEFQKLRRDLEESTLQHEATAAALRKkqadSVAELGEQIDNLQ 1213
Cdd:PRK03918  377 LKKRLTGL--TPEKLEKELEEL-----------EKAKEEIEEEISKITARIGELKKEIKELKK----AIEELKKAKGKCP 439
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1214 RVKQKLEKE-----KSEYKMEIDDLSSNMEAVAKAKANLEKMCRTLEDQLseiksKNDENLRQINDLSAQRARLQTENGE 1288
Cdd:PRK03918  440 VCGRELTEEhrkelLEEYTAELKRIEKELKEIEEKERKLRKELRELEKVL-----KKESELIKLKELAEQLKELEEKLKK 514
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1289 FG-RQLEEKEALVSQLTRGKQAFTQQIEELKRQIEEEVKAKNALAhavqsarhdcdLLREQFEEEQEAKAELQRGMSkan 1367
Cdd:PRK03918  515 YNlEELEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLEELKKKLA-----------ELEKKLDELEEELAELLKELE--- 580
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1368 sevaqwrtkyetdaiqrtEELEESKKKLAQRLQEAE----EQIEAVNSkcaslEKTKQRLQGEVEDLMIDVERANALAAN 1443
Cdd:PRK03918  581 ------------------ELGFESVEELEERLKELEpfynEYLELKDA-----EKELEREEKELKKLEEELDKAFEELAE 637
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1444 LDKKQRNFDKVLAEWKQKYEEgqAELEGAQKEARSLSTELFKMKNSYEETLDQLETLKRenknlqqEISDLTEQLGETGK 1523
Cdd:PRK03918  638 TEKRLEELRKELEELEKKYSE--EEYEELREEYLELSRELAGLRAELEELEKRREEIKK-------TLEKLKEELEEREK 708
                         650
                  ....*....|...
gi 288856329 1524 SIHELEKSKKAVE 1536
Cdd:PRK03918  709 AKKELEKLEKALE 721
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
1203-1708 4.99e-13

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 74.39  E-value: 4.99e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1203 AELGEQIDNLQRVKQKLEKEKSEYKMEIDDLSS-------NMEAVAKAKANLEKMCRTLEDQLSEIKSKNDENlrqindl 1275
Cdd:pfam05557    2 AELIESKARLSQLQNEKKQMELEHKRARIELEKkasalkrQLDRESDRNQELQKRIRLLEKREAEAEEALREQ------- 74
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1276 sAQRARLQTENGE-FGRQLEEKEALVSQLTRGKQAFTQQIEELKRQIEEEVKAKNALAHAVQSARHDCDLLREQFEEEQE 1354
Cdd:pfam05557   75 -AELNRLKKKYLEaLNKKLNEKESQLADAREVISCLKNELSELRRQIQRAELELQSTNSELEELQERLDLLKAKASEAEQ 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1355 AKAELQRgmskansevaqwRTKYETDAIQRTEELEeskKKLAQRLQEAEEqIEAVNSKCAS---LEKTKQRLQGEVEDLM 1431
Cdd:pfam05557  154 LRQNLEK------------QQSSLAEAEQRIKELE---FEIQSQEQDSEI-VKNSKSELARipeLEKELERLREHNKHLN 217
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1432 IDVERANALAANLDKKQRNFDKvlaewkqkYEEGQAELEGAQKEARSLSTELFKMKNSYEETLDQL---ETLKRENKNLQ 1508
Cdd:pfam05557  218 ENIENKLLLKEEVEDLKRKLER--------EEKYREEAATLELEKEKLEQELQSWVKLAQDTGLNLrspEDLSRRIEQLQ 289
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1509 QEISDLTEQLGETGKSIHELEKSKKAVETEKAEIQTALEEAEGTLEHEESKILRVQLELNQVKSEID--RKLAEKDEEIE 1586
Cdd:pfam05557  290 QREIVLKEENSSLTSSARQLEKARRELEQELAQYLKKIEDLNKKLKRHKALVRRLQRRVLLLTKERDgyRAILESYDKEL 369
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1587 QIKRNSQRITDSMQSTLDsevrsrndalrIKKKMEGDLNEMEIQLSHANRQAAEAQKQLRNVQAQLKdaqlhlddAVRGQ 1666
Cdd:pfam05557  370 TMSNYSPQLLERIEEAED-----------MTQKMQAHNEEMEAQLSVAEEELGGYKQQAQTLERELQ--------ALRQQ 430
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|..
gi 288856329  1667 EDMKEQVAMVERRNTLMQsEIEELRAALEQTERGRKVAEQEL 1708
Cdd:pfam05557  431 ESLADPSYSKEEVDSLRR-KLETLELERQRLREQKNELEMEL 471
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
1423-1929 5.00e-13

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 74.83  E-value: 5.00e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1423 LQGEVEDLMIDVERANALAANLDKKQRNFDKVLAEWKQKYEEGQAELEgAQKEARSLSTELFKMKNSYEETLDQLET--- 1499
Cdd:pfam01576    7 MQAKEEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLQAETE-LCAEAEEMRARLAARKQELEEILHELESrle 85
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1500 --------LKRENKNLQQEISDLTEQLGETGKSIHELEKSKKAVETEKAEiqtaLEEAEGTLEHEESKILRVQLELNQVK 1571
Cdd:pfam01576   86 eeeersqqLQNEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKK----LEEDILLLEDQNSKLSKERKLLEERI 161
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1572 SEIDRKLAEKDEE---IEQIKRNSQRITDSMQSTLDSEVRSRNDALRIKKKMEGDLNEMEIQLSHANRQAAEAQKQLRNV 1648
Cdd:pfam01576  162 SEFTSNLAEEEEKaksLSKLKNKHEAMISDLEERLKKEEKGRQELEKAKRKLEGESTDLQEQIAELQAQIAELRAQLAKK 241
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1649 QAQLKDAQLHLDDAvrgqedmKEQVAMVERRNTLMQSEIEELRAALEQTERGRKVAEQElvdaservgllhsqntsllnt 1728
Cdd:pfam01576  242 EEELQAALARLEEE-------TAQKNNALKKIRELEAQISELQEDLESERAARNKAEKQ--------------------- 293
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1729 KKKLEADLVQIQSEVEDTVQEARNAEDKAKKAITDAAMMAEELKKEQDT-SAHLERMKKNLEVTVKDLQHRLDEAENLAM 1807
Cdd:pfam01576  294 RRDLGEELEALKTELEDTLDTTAAQQELRSKREQEVTELKKALEEETRShEAQLQEMRQKHTQALEELTEQLEQAKRNKA 373
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1808 kGGKKQLQKLESRVRELESEVEAEQRRGADAVKGVRKYERRVKELtyqteedkknvnrlqdlvdklQLKVKAYKRQSEEA 1887
Cdd:pfam01576  374 -NLEKAKQALESENAELQAELRTLQQAKQDSEHKRKKLEGQLQEL---------------------QARLSESERQRAEL 431
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|..
gi 288856329  1888 EEQANSHLSKLRKVQHELEEAEERADIAESQVNKLRAKSRDS 1929
Cdd:pfam01576  432 AEKLSKLQSELESVSSLLNEAEGKNIKLSKDVSSLESQLQDT 473
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
845-1588 5.65e-13

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 74.62  E-value: 5.65e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   845 AETEKELATMKEDFVKCKEDLAKAEAKKKELEEKMVALLQEKNDLQLAVA-------SESENLSDAEERCEGLIKSKIQL 917
Cdd:pfam02463  275 KEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKkaekelkKEKEEIEELEKELKELEIKREAE 354
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   918 EAKLKETTERLEDEEEINAELTAKKRKLEDECSELKKDIDdlELTLAKVEKEKHATENKVKNLTEEMAAQDESIGKLTKE 997
Cdd:pfam02463  355 EEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKE--EELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEIL 432
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   998 KKALqeaHQQTLDDLQAEEDKVNTLTKSKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDLENDKQQ 1077
Cdd:pfam02463  433 EEEE---ESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGL 509
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1078 SEEKLKKKDFETSQLLSKIEDEQSLGAQLQKkiKELQARIEELEEEIEAERAARAKVEKQRADLSRELEEISERLEEAGG 1157
Cdd:pfam02463  510 KVLLALIKDGVGGRIISAHGRLGDLGVAVEN--YKVAISTAVIVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKL 587
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1158 ATAAQIEMNKKREAEFQKLRRDLEESTLQHEATAAALRKKQADSVAELGEQ---IDNLQRVKQKLEKEKSEYKMEIDDLS 1234
Cdd:pfam02463  588 KLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKVVEGILKDTELTKLKesaKAKESGLRKGVSLEEGLAEKSEVKAS 667
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1235 SNMEAVAKAKANLEKMCRTLEDQLSEIKSKNDENLRQINDLSA--QRARLQTENGEFGRQLEEKEALVSQLTRGKQAFTQ 1312
Cdd:pfam02463  668 LSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEelKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDE 747
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1313 QIEELKRQIEEEVKAKNALAHAVQSARHDCDLLREQFEE--EQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEE 1390
Cdd:pfam02463  748 EEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLkvEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQE 827
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1391 SKKKLAQRLQEAEEQIEAVNSKCASLEKTKqrlqgevEDLMIDVERANALAANLDKKQRNFDKVLAEWKQKYEEGQAELE 1470
Cdd:pfam02463  828 EKIKEEELEELALELKEEQKLEKLAEEELE-------RLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKK 900
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1471 GAQKEARSLSTELFKMKNSYEETldqletlKRENKNLQQEISDLTEQLGETGKSIHELEKSKKAVETEKAEIQTALEEAE 1550
Cdd:pfam02463  901 ELEEESQKLNLLEEKENEIEERI-------KEEAEILLKYEEEPEELLLEEADEKEKEENNKEEEEERNKRLLLAKEELG 973
                          730       740       750
                   ....*....|....*....|....*....|....*...
gi 288856329  1551 GTLEHEESKILRVQLELNQVKSEIDRKLAEKDEEIEQI 1588
Cdd:pfam02463  974 KVNLMAIEEFEEKEERYNKDELEKERLEEEKKKLIRAI 1011
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1397-1925 5.66e-13

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 74.57  E-value: 5.66e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1397 QRLQEAEEQIEA---VNSKCASLEKTKQRLQG-EVEDLMIDVERANALAANLDKKQRNFDKVLAEWKQKYEEGQAELEGA 1472
Cdd:COG4913   242 EALEDAREQIELlepIRELAERYAAARERLAElEYLRAALRLWFAQRRLELLEAELEELRAELARLEAELERLEARLDAL 321
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1473 QKEARSLSTELfkmknsYEETLDQLETLKRENKNLQQEISDLTEQLGETGKSIHELEKSKKAVETEKAEIQTALEEAEGT 1552
Cdd:COG4913   322 REELDELEAQI------RGNGGDRLEQLEREIERLERELEERERRRARLEALLAALGLPLPASAEEFAALRAEAAALLEA 395
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1553 LEHEESKILRVQLELNQVKSEIDRKLAEKDEEIEQIKRNSQRITDSMQstldsEVRSR-NDALRIKkkmEGDL----NEM 1627
Cdd:COG4913   396 LEEELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNIPARLL-----ALRDAlAEALGLD---EAELpfvgELI 467
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1628 EIQLSHAN-RQAAEaqKQLRNV-------QAQLKDA-----QLHLDDAVRGQ---EDMKEQVAMVERRNTL---MQSEIE 1688
Cdd:COG4913   468 EVRPEEERwRGAIE--RVLGGFaltllvpPEHYAAAlrwvnRLHLRGRLVYErvrTGLPDPERPRLDPDSLagkLDFKPH 545
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1689 ELRAALEQTERGR----KVA-EQELVDASERV---GLLHSQNTSL-LNTKKKLEADLV-------QIQsEVEDTVQEARN 1752
Cdd:COG4913   546 PFRAWLEAELGRRfdyvCVDsPEELRRHPRAItraGQVKGNGTRHeKDDRRRIRSRYVlgfdnraKLA-ALEAELAELEE 624
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1753 AEDKAKKAITDAAMMAEELKKEQDTSAHLERMKKNlEVTVKDLQHRLDEAENlamkggkkQLQKLE---SRVRELESEVE 1829
Cdd:COG4913   625 ELAEAEERLEALEAELDALQERREALQRLAEYSWD-EIDVASAEREIAELEA--------ELERLDassDDLAALEEQLE 695
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1830 AEQRRGADAVKGVRKYERRVKELTYQTEEDKKNVNRLQDLVDKLQLKVKAYKRQSEEA----EEQANSHLSKLRKVQHEL 1905
Cdd:COG4913   696 ELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALLEErfaaALGDAVERELRENLEERI 775
                         570       580
                  ....*....|....*....|
gi 288856329 1906 EEAEERADIAESQVNKLRAK 1925
Cdd:COG4913   776 DALRARLNRAEEELERAMRA 795
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
1072-1924 7.99e-13

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 74.24  E-value: 7.99e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1072 ENDKQQSEEKLKKKDFETSQLLSKIEDEQSLGAQLQKKIKELQARIEELEEeieaeRAARAKVEKQRADLSRELEEISER 1151
Cdd:pfam02463  145 EIIAMMKPERRLEIEEEAAGSRLKRKKKEALKKLIEETENLAELIIDLEEL-----KLQELKLKEQAKKALEYYQLKEKL 219
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1152 LEEAGGATAAQIEmnkKREAEFQKLRRDLEESTLQHEATAAALRKKQADSVAELGEQIDNLQRVKQKLEKEKSEYKMEID 1231
Cdd:pfam02463  220 ELEEEYLLYLDYL---KLNEERIDLLQELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEE 296
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1232 DLSSNMEavakakaNLEKMCRTLEDQLSEIKSKNDENLRQINDLSAQRARLQTENGEFGRQLEEKEALVSQLTRGKQAFT 1311
Cdd:pfam02463  297 ELKSELL-------KLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLE 369
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1312 QQIEEL--------KRQIEEEVKAKNALAHAVQSARHDCDLLREQFEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQ 1383
Cdd:pfam02463  370 QLEEELlakkklesERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEE 449
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1384 RTEELEESKKKLAQRLQEAEEQIEAvnskcASLEKTKQRLQGEVEDLMIDVERANAL---AANLDKKQRNFDKVLAEWKQ 1460
Cdd:pfam02463  450 KEELEKQELKLLKDELELKKSEDLL-----KETQLVKLQEQLELLLSRQKLEERSQKeskARSGLKVLLALIKDGVGGRI 524
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1461 KYEEGQAELEGAQKEARSLSTELFKMKNSYEETLDQLETLKRENKNLQQEISDLTEQLGETGKSIHELEKSKKAVETEKA 1540
Cdd:pfam02463  525 ISAHGRLGDLGVAVENYKVAISTAVIVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILN 604
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1541 EIQTALEEAEGTLEHEESKILRVQLELNQVKSEIDRKLAEKDEEIEQIKRNSQRITDSMQSTLDSEVRSRNDALRIKKKM 1620
Cdd:pfam02463  605 LAQLDKATLEADEDDKRAKVVEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEK 684
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1621 EGDLNEMEIQLSHANRQAAEAQKQLRNVQaQLKDAQLHLDDAVRGQEDMKEQVAMVERRNTLMQSEIEELRAALEQTERG 1700
Cdd:pfam02463  685 AESELAKEEILRRQLEIKKKEQREKEELK-KLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKE 763
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1701 RKVAEQELVDASERVGLLHsqntsllNTKKKLEADLVQIQSEVEDTVQEARnaEDKAKKAITDAAMMAEELKKEQDTSAH 1780
Cdd:pfam02463  764 EEKSELSLKEKELAEEREK-------TEKLKVEEEKEEKLKAQEEELRALE--EELKEEAELLEEEQLLIEQEEKIKEEE 834
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1781 LERMKKNLEVTVKDLQHRLDEAENLAMKGGKKQLQKLESRVRELESEVEAEQRRGADAVKGVRKYERRVKELTY---QTE 1857
Cdd:pfam02463  835 LEELALELKEEQKLEKLAEEELERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKlnlLEE 914
                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 288856329  1858 EDKKNVNRLQDLVDKLQLKVKAYKRQSEEAEEQANSHLSKLRKVQHELEEAEERADIAESQVNKLRA 1924
Cdd:pfam02463  915 KENEIEERIKEEAEILLKYEEEPEELLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAIE 981
PTZ00121 PTZ00121
MAEBL; Provisional
1262-1921 1.41e-12

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 73.64  E-value: 1.41e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1262 KSKNDENLRQINDLSAQRARLQTENGEFGRQLEEKEALVSQLTRGKQAftQQIEELkRQIEEEVKAKNALAHAVQSARHD 1341
Cdd:PTZ00121 1086 DNRADEATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEA--RKAEDA-RKAEEARKAEDAKRVEIARKAED 1162
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1342 CDLLREQFEEEQEAKAELQRGMSKANsEVAQWRTKYETDAIQRTEELEESKKKLAQRLQEAEEQIEAVnsKCASLEKTKQ 1421
Cdd:PTZ00121 1163 ARKAEEARKAEDAKKAEAARKAEEVR-KAEELRKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAV--KKAEEAKKDA 1239
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1422 RLQGEVEDLMIDVERANALAANLDKKQRNFDKVLAEWKQKYEEGQAELEGAQKEARSLSTELFKMknsyeETLDQLETLK 1501
Cdd:PTZ00121 1240 EEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKA-----DEAKKKAEEA 1314
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1502 RENKNLQQEISDLTEQLGETGKsihELEKSKKAVETEKAEIQTALEEAEGTLEHEESKILRVQLElnQVKSEIDRKLAEK 1581
Cdd:PTZ00121 1315 KKADEAKKKAEEAKKKADAAKK---KAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEA--KKKADAAKKKAEE 1389
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1582 DEEIEQIKRNSQRitdsmqstldsevrSRNDALRIKKKMEGDLNEMEIQLSHANRQAAEAQKQLRNVQAQLKDAQLHLDD 1661
Cdd:PTZ00121 1390 KKKADEAKKKAEE--------------DKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEE 1455
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1662 AVRGQEDMKEqvAMVERRNTLMQSEIEELRAALE---QTERGRKVAEQELVDASERvgllhsqntsllntKKKLEADlvq 1738
Cdd:PTZ00121 1456 AKKAEEAKKK--AEEAKKADEAKKKAEEAKKADEakkKAEEAKKKADEAKKAAEAK--------------KKADEAK--- 1516
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1739 iQSEVEDTVQEARNAEDKAKkaiTDAAMMAEELKKEQDTSaHLERMKKNLEVTVKDLQHRLDEAENLAMKGGKKQLQKLE 1818
Cdd:PTZ00121 1517 -KAEEAKKADEAKKAEEAKK---ADEAKKAEEKKKADELK-KAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEE 1591
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1819 SRVREL-------------ESEVEAEQRRGADAVKGVRKYERRVKELTYQTEEDKKNVNRL-----QDLVDKLQLKVKAY 1880
Cdd:PTZ00121 1592 ARIEEVmklyeeekkmkaeEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELkkaeeENKIKAAEEAKKAE 1671
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*.
gi 288856329 1881 --KRQSEE---AEEQANSHLSKLRKVQHELEEAEERADIAESQVNK 1921
Cdd:PTZ00121 1672 edKKKAEEakkAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKK 1717
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1247-1711 1.61e-12

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 72.49  E-value: 1.61e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1247 LEKMCRTLEDQLSEIKSKNDE-NLRQINDLSAQRARLQTENGEFGRQLEEKEALVSQLTRGKQaftqQIEELKRQIEEEV 1325
Cdd:COG4717    47 LLERLEKEADELFKPQGRKPElNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEA----ELEELREELEKLE 122
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1326 KAKNALAHAVQSARHDCDLLR-----EQFEEEQEAKAELQRGMSKANSEVAQWRTkyetdaiQRTEELEESKKKLAQRLQ 1400
Cdd:COG4717   123 KLLQLLPLYQELEALEAELAElperlEELEERLEELRELEEELEELEAELAELQE-------ELEELLEQLSLATEEELQ 195
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1401 EAEEQIEAVNSKCASLEKTKQRLQGEVEDLMIDVERANALAANLDKKQRNFDkvlAEWKQKYEEGQAELEGAQKEARSLS 1480
Cdd:COG4717   196 DLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKE---ARLLLLIAAALLALLGLGGSLLSLI 272
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1481 ------------------TELFKMKNSYEETLDQLETLKRENKNLQQEISDLTEQLG-ETGKSIHELEKSKKAVEtEKAE 1541
Cdd:COG4717   273 ltiagvlflvlgllallfLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGlPPDLSPEELLELLDRIE-ELQE 351
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1542 IQTALEEAEGTLEHEESKILRVQLeLNQVKSEIDRKLAEKDEEIEQIKRNSQRItDSMQSTLDSEVRSRNDALRikkkmE 1621
Cdd:COG4717   352 LLREAEELEEELQLEELEQEIAAL-LAEAGVEDEEELRAALEQAEEYQELKEEL-EELEEQLEELLGELEELLE-----A 424
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1622 GDLNEMEIQLSHANRQAAEAQKQLRNVQAQLKDAQLHLDDAVRGQE--DMKEQVAMVERRNTLMQSEIEELRAALEQTER 1699
Cdd:COG4717   425 LDEEELEEELEELEEELEELEEELEELREELAELEAELEQLEEDGElaELLQELEELKAELRELAEEWAALKLALELLEE 504
                         490
                  ....*....|..
gi 288856329 1700 GRKVAEQELVDA 1711
Cdd:COG4717   505 AREEYREERLPP 516
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1198-1415 1.70e-12

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 71.33  E-value: 1.70e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1198 QADSVAELGEQIDNLQRVKQKLEKEKSEYKMEIDDLSSNMEAVAKAKANLEKMCRTLEDQLSEIKSKNDENLRQINDLSA 1277
Cdd:COG4942    18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRA 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1278 QRARLQTENGEF-------GRQLEEKEAL----VSQLTRGKQAFTQQIEELKRQIEEEVKAKNALAHAVQSARHDCDLLR 1346
Cdd:COG4942    98 ELEAQKEELAELlralyrlGRQPPLALLLspedFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELE 177
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 288856329 1347 EQFEEEQEAKAELQRGMSKANSEVAQWRTKYETDAiQRTEELEESKKKLAQRLQEAEEQIEAVNSKCAS 1415
Cdd:COG4942   178 ALLAELEEERAALEALKAERQKLLARLEKELAELA-AELAELQQEAEELEALIARLEAEAAAAAERTPA 245
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
897-1424 2.39e-12

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 72.40  E-value: 2.39e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  897 SENLSDAEERCEGLIKSKIQLEA---KLKETTERLEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 973
Cdd:PRK03918  213 SSELPELREELEKLEKEVKELEElkeEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKELKEKA 292
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  974 ENKVKnLTEEMAAQDESIGKLTKEKKALQE---AHQQTLDDLQAEEDKVNTLTKSKTKLEQQVDDLEGSLEQEKKLRMDL 1050
Cdd:PRK03918  293 EEYIK-LSEFYEEYLDELREIEKRLSRLEEeinGIEERIKELEEKEERLEELKKKLKELEKRLEELEERHELYEEAKAKK 371
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1051 ERAKRKLEgdlKLAQESIMDLENDKQQSEEKLKKKDFETSQLLSKIEDEQSLGAQLQKKIKELQARIEE-----LEEEIE 1125
Cdd:PRK03918  372 EELERLKK---RLTGLTPEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKcpvcgRELTEE 448
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1126 AERAARAKVEKQRADLSRELEEISERLEEAgGATAAQIEMNKKREAEFQKLRRDLEestlQHEATAAALRKKQADSVAEL 1205
Cdd:PRK03918  449 HRKELLEEYTAELKRIEKELKEIEEKERKL-RKELRELEKVLKKESELIKLKELAE----QLKELEEKLKKYNLEELEKK 523
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1206 GEQIDNLQRVKQKLEKEKSEYKMEIDDLssnmEAVAKAKANLEKMCRTLEDQLSEIKSKNDE-NLRQINDLSAQRARLQT 1284
Cdd:PRK03918  524 AEEYEKLKEKLIKLKGEIKSLKKELEKL----EELKKKLAELEKKLDELEEELAELLKELEElGFESVEELEERLKELEP 599
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1285 ENGEFGRQLEEKEALVSQLTRgkqaftqqIEELKRQIEEEVKAKNALAHAVQSARHDCDLLREQFEEEQEAKAElqRGMS 1364
Cdd:PRK03918  600 FYNEYLELKDAEKELEREEKE--------LKKLEEELDKAFEELAETEKRLEELRKELEELEKKYSEEEYEELR--EEYL 669
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1365 KANSEVAQWRTKYEtdaiqRTEELEESKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQ 1424
Cdd:PRK03918  670 ELSRELAGLRAELE-----ELEKRREEIKKTLEKLKEELEEREKAKKELEKLEKALERVE 724
PTZ00121 PTZ00121
MAEBL; Provisional
837-1517 6.66e-12

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 71.33  E-value: 6.66e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  837 KIKPLLKSAETEKELATMKEDFVKCKEDLAKAEakkkeleekmvallqekndlqlavasesenlsdaeercegliKSKIQ 916
Cdd:PTZ00121 1330 KADAAKKKAEEAKKAAEAAKAEAEAAADEAEAA------------------------------------------EEKAE 1367
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  917 LEAKLKETTERLEDEEEINAELTAKKRKLEDECSELKKDIDDLEltlAKVEKEKHATENKVKnlTEEMAAQDEsIGKLTK 996
Cdd:PTZ00121 1368 AAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELK---KAAAAKKKADEAKKK--AEEKKKADE-AKKKAE 1441
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  997 EKKALQEAHQqtlddlQAEEDKVNTLTKSKTKLEQQVDDLEGSLEQEKKlrmdLERAKRKLEGDLKLAQEsIMDLENDKQ 1076
Cdd:PTZ00121 1442 EAKKADEAKK------KAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKK----ADEAKKKAEEAKKKADE-AKKAAEAKK 1510
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1077 QSEEKLKKKDFETSQLLSKIED----EQSLGAQLQKKIKELQARIEELEEEIEAERAARAKVEKQRADLSRELEEISERL 1152
Cdd:PTZ00121 1511 KADEAKKAEEAKKADEAKKAEEakkaDEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAE 1590
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1153 EEAGGATAAQIEMNKKREAEfqKLRRDLEESTLQHEATAAALRKKQadsVAELGEQIDNLQRVKQKLEKEKSEYKMEIDD 1232
Cdd:PTZ00121 1591 EARIEEVMKLYEEEKKMKAE--EAKKAEEAKIKAEELKKAEEEKKK---VEQLKKKEAEEKKKAEELKKAEEENKIKAAE 1665
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1233 LSSNMEAvAKAKANLEKMCRTLEDQLSEIKSKNDENLRQINDLSAQRARLQTENGEFGRQLEEKEALVSQLTRGKQAFTQ 1312
Cdd:PTZ00121 1666 EAKKAEE-DKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKK 1744
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1313 QIEELKRQIEEEVKAKNALAHAVQSARHDCDLLREQFEEEQEAKAELQRGM-------SKANSEVAQWRTKYETDAIQRT 1385
Cdd:PTZ00121 1745 KAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEvdkkikdIFDNFANIIEGGKEGNLVINDS 1824
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1386 EELEESKKKlaqrlqeaeeqiEAVNSKCASLEKTKQRLQGEVEDLMIDVERANAlAANLDKKQRNFDKVLAEWKQKYEEG 1465
Cdd:PTZ00121 1825 KEMEDSAIK------------EVADSKNMQLEEADAFEKHKFNKNNENGEDGNK-EADFNKEKDLKEDDEEEIEEADEIE 1891
                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|....
gi 288856329 1466 QAELEGAQKEarsLSTELFKMKN--SYEETLDQLETLKRENKNLQQEISDLTEQ 1517
Cdd:PTZ00121 1892 KIDKDDIERE---IPNNNMAGKNndIIDDKLDKDEYIKRDAEETREEIIKISKK 1942
Myosin_N pfam02736
Myosin N-terminal SH3-like domain; This domain has an SH3-like fold. It is found at the ...
33-78 1.39e-11

Myosin N-terminal SH3-like domain; This domain has an SH3-like fold. It is found at the N-terminus of many but not all myosins. The function of this domain is unknown.


Pssm-ID: 460670  Cd Length: 45  Bit Score: 60.91  E-value: 1.39e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 288856329    33 DAKTACYVVDDKELYVKGTIKSKDGGKVTVITlDTKEEKVVKEDDV 78
Cdd:pfam02736    1 DAKKLVWVPDPKEGFVKGEIKEEEGDKVTVET-EDGKTVTVKKDDV 45
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
894-1268 1.43e-11

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 70.10  E-value: 1.43e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   894 ASESENLSDAEERCEGLIKSKIQLEAKLKETTERLEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 973
Cdd:TIGR02169  670 RSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSL 749
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   974 ENKVKNLTEEMAAQDESIGKLTKEKKALQEAhqqtLDDLQAEED--KVNTLTKSKTKLEQQVDDLEGSLEqekklrmDLE 1051
Cdd:TIGR02169  750 EQEIENVKSELKELEARIEELEEDLHKLEEA----LNDLEARLShsRIPEIQAELSKLEEEVSRIEARLR-------EIE 818
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1052 RAKRKLEGDLKLAQESIMDLENDKQQSEEKLKKKDFETSQLLSKIEDEQSLGAQLQKKIKELQARIEELEEEIEAERAAR 1131
Cdd:TIGR02169  819 QKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQL 898
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1132 AKVEKQRADLSRELEEISERLEEAGGATAA------QIEMNKKREAEFQKLRRDLEESTLQHEATAAALRK------KQA 1199
Cdd:TIGR02169  899 RELERKIEELEAQIEKKRKRLSELKAKLEAleeelsEIEDPKGEDEEIPEEELSLEDVQAELQRVEEEIRAlepvnmLAI 978
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 288856329  1200 DSVAELGEQIDNLQRVKQKLEKEKSEYKMEIDDL-----SSNMEAVAKAKANLEKMCRTLEDQLSEIKSKNDEN 1268
Cdd:TIGR02169  979 QEYEEVLKRLDELKEKRAKLEEERKAILERIEEYekkkrEVFMEAFEAINENFNEIFAELSGGTGELILENPDD 1052
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
933-1438 1.73e-11

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 69.76  E-value: 1.73e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   933 EINAELTAKKRKLEDECSELKKD--IDDLELTLAKVEKEKHATENkvKNLTEEMAAQDESIGKLTKEKKALQEAHQQTLD 1010
Cdd:pfam15921  328 QLRSELREAKRMYEDKIEELEKQlvLANSELTEARTERDQFSQES--GNLDDQLQKLLADLHKREKELSLEKEQNKRLWD 405
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1011 dlqaeEDKVNTLTKSktKLEQQVDDLEGSLEQEKKLrmdLERAKRKLEGDLKLAQESImdlendkQQSEEKLKKKDFETS 1090
Cdd:pfam15921  406 -----RDTGNSITID--HLRRELDDRNMEVQRLEAL---LKAMKSECQGQMERQMAAI-------QGKNESLEKVSSLTA 468
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1091 QLLSKIEdeqslgaQLQKKIKELQARIEELEEEieaeraarakvEKQRADLSRELEEISERLEeaggATAAQIEMNKKRE 1170
Cdd:pfam15921  469 QLESTKE-------MLRKVVEELTAKKMTLESS-----------ERTVSDLTASLQEKERAIE----ATNAEITKLRSRV 526
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1171 ----AEFQKLRRDLEE-STLQHEATAAALRKKQADSVAE-LGEQIDNLQ-------RVKQKLEKEKSEYKMEIDDLSSNM 1237
Cdd:pfam15921  527 dlklQELQHLKNEGDHlRNVQTECEALKLQMAEKDKVIEiLRQQIENMTqlvgqhgRTAGAMQVEKAQLEKEINDRRLEL 606
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1238 EAVAKAKANLEKMCRTLEDQLSEIK-------SKNDENLRQINDLSAQRARL----QTENGEFGRQLEEKEALVSQLTRG 1306
Cdd:pfam15921  607 QEFKILKDKKDAKIRELEARVSDLElekvklvNAGSERLRAVKDIKQERDQLlnevKTSRNELNSLSEDYEVLKRNFRNK 686
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1307 KQAFTQQIEELKRQIE----EEVKAKNALAHAVQSARHdcdLLREQFEEEQEAKAelQRGMSKANSEVAQWRTKYETDAI 1382
Cdd:pfam15921  687 SEEMETTTNKLKMQLKsaqsELEQTRNTLKSMEGSDGH---AMKVAMGMQKQITA--KRGQIDALQSKIQFLEEAMTNAN 761
                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 288856329  1383 QRTEELEESKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQGEVEDLMIDVERAN 1438
Cdd:pfam15921  762 KEKHFLKEEKNKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVANMEVALDKAS 817
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
884-1285 2.71e-11

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 68.89  E-value: 2.71e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   884 QEKNDLQLAVASESENLSDAEERcegLIKSKIQLEAKLKEtterLEDEEEINAELTAKKRKLEDECSELKKD-----IDD 958
Cdd:TIGR04523  239 QEINEKTTEISNTQTQLNQLKDE---QNKIKKQLSEKQKE----LEQNNKKIKELEKQLNQLKSEISDLNNQkeqdwNKE 311
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   959 LELTLAKVEKEKHATENKVKNLTEEMAAQDESIGKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTK-------SKTKLEQ 1031
Cdd:TIGR04523  312 LKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKenqsykqEIKNLES 391
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1032 QVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDLENDKQQSEEKLKKKDFETSQLLSKIEDEQSLGAQLQKKIK 1111
Cdd:TIGR04523  392 QINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLK 471
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1112 ELQARIEELEEEIEAERAARAKVEKQRADLSRELEEISERLEEAGGATAAQIEMNKKREAEfqKLRRDLEESTLQHEATA 1191
Cdd:TIGR04523  472 VLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESE--KKEKESKISDLEDELNK 549
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1192 AALRKKQA---DSVAELGEQIDNLQRVKQKLEKEKSEYKMEIDDLSSNMEAVAKAKANLEKMCRTLEDQLSEIKSKNDEN 1268
Cdd:TIGR04523  550 DDFELKKEnleKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKL 629
                          410
                   ....*....|....*..
gi 288856329  1269 LRQINDLSAQRARLQTE 1285
Cdd:TIGR04523  630 SSIIKNIKSKKNKLKQE 646
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
1147-1907 2.85e-11

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 68.92  E-value: 2.85e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1147 EISERLEEAGGATAAQIEMNKKREAEFQKLRRDLEEstLQHEATaaalrkkqadSVAELGEQIDNLQRVKQKLEKEKSEY 1226
Cdd:TIGR00606  221 EIRDQITSKEAQLESSREIVKSYENELDPLKNRLKE--IEHNLS----------KIMKLDNEIKALKSRKKQMEKDNSEL 288
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1227 KMEIDD-LSSNMEAVAKAKANLEKMCRTLEDQLSEIKSKNDENLRQINDLSAQRARLQTENGEFGRQLE--EKEALVSQL 1303
Cdd:TIGR00606  289 ELKMEKvFQGTDEQLNDLYHNHQRTVREKERELVDCQRELEKLNKERRLLNQEKTELLVEQGRLQLQADrhQEHIRARDS 368
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1304 TRGKQAFTQQIEELKRQIEEEVKAKNALAHAVQSARHDCDLLREQFEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQ 1383
Cdd:TIGR00606  369 LIQSLATRLELDGFERGPFSERQIKNFHTLVIERQEDEAKTAAQLCADLQSKERLKQEQADEIRDEKKGLGRTIELKKEI 448
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1384 RTEELEESKKKLAQrLQEAEEQIEAVNSKCASLEKTKQRL-----QGEVEDLMIDVERANALAANLDKKQRNFDKVLAEw 1458
Cdd:TIGR00606  449 LEKKQEELKFVIKE-LQQLEGSSDRILELDQELRKAERELskaekNSLTETLKKEVKSLQNEKADLDRKLRKLDQEMEQ- 526
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1459 KQKYEEGQAELEGAQKEARSLSTELFKMKNSYEETLDQLETLKRENKNLQQEISDLTEQLGETGKSIHELEKSKKAVETE 1538
Cdd:TIGR00606  527 LNHHTTTRTQMEMLTKDKMDKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASLEQN 606
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1539 KAEIQTALEEAEGTLEHEESKILRV-QLELNQVKSEIDRKLAEKDEEIEQIKRNSQRITDSMQSTLDSEVRSRNDALRIK 1617
Cdd:TIGR00606  607 KNHINNELESKEEQLSSYEDKLFDVcGSQDEESDLERLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRV 686
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1618 KKMEGDLNEMEIQLSHANRQAAEAQKQLRNVQAQLKDAQLHLDDAVRGQE---DMKE-QVAMVERRNTLMQSEIEELRAA 1693
Cdd:TIGR00606  687 FQTEAELQEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLAPGRQsiiDLKEkEIPELRNKLQKVNRDIQRLKND 766
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1694 LEQTER--GRKVAEQELV-DASERVGLLHSQNTSLLNTKKKLEADLVQIQS-EVEDTVQEARNAEDKAKKAITDAAMMAE 1769
Cdd:TIGR00606  767 IEEQETllGTIMPEEESAkVCLTDVTIMERFQMELKDVERKIAQQAAKLQGsDLDRTVQQVNQEKQEKQHELDTVVSKIE 846
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1770 ELKKeqdTSAHLERMKKNLEVTVKDLQ-HRLDEAENLAMKGG-KKQLQKLESRVRELESEVEAEQRRGADAVKGVRKYER 1847
Cdd:TIGR00606  847 LNRK---LIQDQQEQIQHLKSKTNELKsEKLQIGTNLQRRQQfEEQLVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQ 923
                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 288856329  1848 RVKELTYQTEEDKKNVN---------------RLQDLVDKLQLKVKAYKRQSEEAEEQANSHLSKLRKVQHELEE 1907
Cdd:TIGR00606  924 EKEELISSKETSNKKAQdkvndikekvknihgYMKDIENKIQDGKDDYLKQKETELNTVNAQLEECEKHQEKINE 998
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
916-1353 2.94e-11

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 68.64  E-value: 2.94e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  916 QLEAKLKEtterLEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEK--HATENKVKNLTEEMAAQDESIGK 993
Cdd:COG4717    75 ELEEELKE----AEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLqlLPLYQELEALEAELAELPERLEE 150
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  994 LTKEKKALQEAHQQtLDDLQAEedkvntLTKSKTKLEQQVDDLegSLEQEKKLRmDLERAKRKLEGDLKLAQESIMDLEN 1073
Cdd:COG4717   151 LEERLEELRELEEE-LEELEAE------LAELQEELEELLEQL--SLATEEELQ-DLAEELEELQQRLAELEEELEEAQE 220
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1074 DKQQSEEKLK--KKDFETSQLLSKIEDEQSLGA--------------------------------------QLQKKIKEL 1113
Cdd:COG4717   221 ELEELEEELEqlENELEAAALEERLKEARLLLLiaaallallglggsllsliltiagvlflvlgllallflLLAREKASL 300
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1114 QARIEELEEEIEAERAARAKVEKQRADLSRELEEISERLEEAGGATAAQIEMNKKREAEFQKLRRDLEESTLQheataAA 1193
Cdd:COG4717   301 GKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEELEQEIA-----AL 375
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1194 LRKKQADSVAELGEQIDNLQRvKQKLEKEKSEYKMEIDDLSSNMEAVAkAKANLEkmcrTLEDQLSEIKSKNDENLRQIN 1273
Cdd:COG4717   376 LAEAGVEDEEELRAALEQAEE-YQELKEELEELEEQLEELLGELEELL-EALDEE----ELEEELEELEEELEELEEELE 449
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1274 DLSAQRARLQTENgefgRQLEEKEALVSQLtrgkqaftQQIEELKRQIEEEVKAKNALAHAVQSARHdcdlLREQFEEEQ 1353
Cdd:COG4717   450 ELREELAELEAEL----EQLEEDGELAELL--------QELEELKAELRELAEEWAALKLALELLEE----AREEYREER 513
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1390-1601 3.08e-11

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 67.48  E-value: 3.08e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1390 ESKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQGEVEDLMIDVERANALAANLDKKQRNFDKVLAEWKQKYEEGQAEL 1469
Cdd:COG4942    20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1470 EGAQKEARSLSTELFKMKN-----------SYEETLDQLETLKRENKNLQQEISDLTEQLgetgksiHELEKSKKAVETE 1538
Cdd:COG4942   100 EAQKEELAELLRALYRLGRqpplalllspeDFLDAVRRLQYLKYLAPARREQAEELRADL-------AELAALRAELEAE 172
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 288856329 1539 KAEIQTALEEaegtLEHEESKILRVQLELNQVKSEIDRKLAEKDEEIEQIKRNSQRITDSMQS 1601
Cdd:COG4942   173 RAELEALLAE----LEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIAR 231
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1490-1920 3.94e-11

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 68.40  E-value: 3.94e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1490 YEETLDQLETLKRENKNLQQeISDLTEQLGETGKSIHELEKSKKAVETEKAeiQTALEEAEGTLEHEESKILRVQLELNQ 1569
Cdd:COG4913   237 LERAHEALEDAREQIELLEP-IRELAERYAAARERLAELEYLRAALRLWFA--QRRLELLEAELEELRAELARLEAELER 313
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1570 VKSEIDRKLAEKDEEIEQIKRNSQRITDSMQSTLDSEVRSRNDALRIKKKMEGDLNEMEIQLSHA----NRQAAEAQKQL 1645
Cdd:COG4913   314 LEARLDALREELDELEAQIRGNGGDRLEQLEREIERLERELEERERRRARLEALLAALGLPLPASaeefAALRAEAAALL 393
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1646 RNVQAQLKDAQLHLDDAVRGQEDMKEQ-------VAMVERRNTLMQSEIEELRAALEQtERGRKVAE----QELVD---- 1710
Cdd:COG4913   394 EALEEELEALEEALAEAEAALRDLRRElreleaeIASLERRKSNIPARLLALRDALAE-ALGLDEAElpfvGELIEvrpe 472
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1711 ------ASERVglLHSQNTSLLNTkkklEADLVQIQSEVEDT-------VQEARNAEDKAKKAITDAAMMAEELKKEQ-- 1775
Cdd:COG4913   473 eerwrgAIERV--LGGFALTLLVP----PEHYAAALRWVNRLhlrgrlvYERVRTGLPDPERPRLDPDSLAGKLDFKPhp 546
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1776 ------------------DTSAHLER----------MKKNLEVTVKDLQHRLDE--------AENLAMKggKKQLQKLES 1819
Cdd:COG4913   547 frawleaelgrrfdyvcvDSPEELRRhpraitragqVKGNGTRHEKDDRRRIRSryvlgfdnRAKLAAL--EAELAELEE 624
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1820 RVRELESEVEA---------EQRRGADAVKGVRKYERRVKELTY---QTEEDKKNVNRLQDLVDKLQLKVKAYKRQSEEA 1887
Cdd:COG4913   625 ELAEAEERLEAleaeldalqERREALQRLAEYSWDEIDVASAEReiaELEAELERLDASSDDLAALEEQLEELEAELEEL 704
                         490       500       510
                  ....*....|....*....|....*....|...
gi 288856329 1888 EEQANSHLSKLRKVQHELEEAEERADIAESQVN 1920
Cdd:COG4913   705 EEELDELKGEIGRLEKELEQAEEELDELQDRLE 737
PTZ00121 PTZ00121
MAEBL; Provisional
1527-1935 6.46e-11

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 68.24  E-value: 6.46e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1527 ELEKSKKAVETEkaeiqtALEEAEGTLEhEESKILRVQLElNQVKSEIDRKLAEKDEEIEQIKR--NSQRITDSMQSTLD 1604
Cdd:PTZ00121 1080 DFDAKEDNRADE------ATEEAFGKAE-EAKKTETGKAE-EARKAEEAKKKAEDARKAEEARKaeDARKAEEARKAEDA 1151
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1605 SEV---RSRNDALRIK--------KKMEGDLNEMEIQLSHANRQAAEAqkqlRNVQAQLKDAQLHLDDAVRGQEDMKEQV 1673
Cdd:PTZ00121 1152 KRVeiaRKAEDARKAEearkaedaKKAEAARKAEEVRKAEELRKAEDA----RKAEAARKAEEERKAEEARKAEDAKKAE 1227
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1674 AMverrntlmqSEIEELRAALEQTERGRKVAEQELVDASERVGLLH-SQNTSLLNTKKKLEADLVQIQSEVEDTvQEARN 1752
Cdd:PTZ00121 1228 AV---------KKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHfARRQAAIKAEEARKADELKKAEEKKKA-DEAKK 1297
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1753 AEDKAKkaITDAAMMAEELKKEQDTSAHLERMKKNLEVTVKDLQH--RLDEAENLAMKGGKKQLQKLESRVRELESEVEa 1830
Cdd:PTZ00121 1298 AEEKKK--ADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEakKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKE- 1374
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1831 EQRRGADAVKGVRKYERRVKELTYQTEEDKKNVNRLQdlvdklqlKVKAYKRQSEEAEEQANS--HLSKLRKVQHELEEA 1908
Cdd:PTZ00121 1375 EAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELK--------KAAAAKKKADEAKKKAEEkkKADEAKKKAEEAKKA 1446
                         410       420
                  ....*....|....*....|....*....
gi 288856329 1909 EERADIAES--QVNKLRAKSRDSGKGKDA 1935
Cdd:PTZ00121 1447 DEAKKKAEEakKAEEAKKKAEEAKKADEA 1475
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
1213-1892 7.40e-11

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 67.35  E-value: 7.40e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1213 QRVKQKLEKEKSEYK---MEIDDLSSNMEAVAKAKANLEKMCRTLEDQLSEIKSKNDENLRQINDLSAQRARLqteNGEF 1289
Cdd:TIGR04523   36 KQLEKKLKTIKNELKnkeKELKNLDKNLNKDEEKINNSNNKIKILEQQIKDLNDKLKKNKDKINKLNSDLSKI---NSEI 112
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1290 GRQLEEKEALVSQLTRGKQaftqQIEELKRQIEEEVKAKNALAHAVQSARHDCDLLREQFEEEQEAKAELQRGMSKANSE 1369
Cdd:TIGR04523  113 KNDKEQKNKLEVELNKLEK----QKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLNIQKN 188
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1370 VAQWRTKYetdaiQRTEELEESKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQGEVEDLMIDVERANALAANLDKKQR 1449
Cdd:TIGR04523  189 IDKIKNKL-----LKLELLLSNLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQN 263
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1450 NFDKVLAEWKQKYEEGQAELEGAQKEARSLSTELFKMKNSYEEtlDQLETLKRENKNLQQEISDLTEQLGETGKSIHELE 1529
Cdd:TIGR04523  264 KIKKQLSEKQKELEQNNKKIKELEKQLNQLKSEISDLNNQKEQ--DWNKELKSELKNQEKKLEEIQNQISQNNKIISQLN 341
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1530 KSKKAVETEKAEiqtaleeaegtleheeskilrvqleLNQVKSEIDRKLAEKDEEIEQIKRNSQRITDSMQStLDSEVRS 1609
Cdd:TIGR04523  342 EQISQLKKELTN-------------------------SESENSEKQRELEEKQNEIEKLKKENQSYKQEIKN-LESQIND 395
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1610 RNDALRIKKKMEgdlNEMEIQLSHANRQAAEAQKQLRNVQAQLKDAQLHLDDAVRGQEDMKEQVAMVERRNTLMQSEIEE 1689
Cdd:TIGR04523  396 LESKIQNQEKLN---QQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKV 472
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1690 LRAALEQTERGRKVAEQELVDASERVGLLHSQNTSLLNTKKKLEADLVQIQSEVEDTVQEARNAEDKAKKAITDAAMMAE 1769
Cdd:TIGR04523  473 LSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEDELNKDDF 552
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1770 ELKKEqdtsahlermkkNLEVTVKDLQHRLDEaenlaMKGGKKQLQKLESRVRELESEVEAEQRrgaDAVKGVRKYERRV 1849
Cdd:TIGR04523  553 ELKKE------------NLEKEIDEKNKEIEE-----LKQTQKSLKKKQEEKQELIDQKEKEKK---DLIKEIEEKEKKI 612
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|...
gi 288856329  1850 KELTYQTEEDKKNVNRLQDLVDKLQLKVKAYKRQSEEAEEQAN 1892
Cdd:TIGR04523  613 SSLEKELEKAKKENEKLSSIIKNIKSKKNKLKQEVKQIKETIK 655
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
843-1426 1.14e-10

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 66.99  E-value: 1.14e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  843 KSAETEKELATMKEDFVKCKEDLAKAEAKKKELEEKMVALLQEKNDLqlavaseSENLSDAEERCEGLikskiqleakLK 922
Cdd:PRK02224  231 QARETRDEADEVLEEHEERREELETLEAEIEDLRETIAETEREREEL-------AEEVRDLRERLEEL----------EE 293
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  923 ETTERLEDEEEINAELTAkkrkLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAAQDESIGKLTKEKKALQ 1002
Cdd:PRK02224  294 ERDDLLAEAGLDDADAEA----VEARREELEDRDEELRDRLEECRVAAQAHNEEAESLREDADDLEERAEELREEAAELE 369
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1003 EAHQQTLDDLQAEEDKVNTLTKSKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDLENDKQQSEEKL 1082
Cdd:PRK02224  370 SELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERDELREREAELEATLRTARERVEEAEALL 449
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1083 KK-------KDFETSQLLSKIEDEqslgaqlQKKIKELqarieeleeeieaeraarakvEKQRADLSRELEEISERLEEA 1155
Cdd:PRK02224  450 EAgkcpecgQPVEGSPHVETIEED-------RERVEEL---------------------EAELEDLEEEVEEVEERLERA 501
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1156 GGATAAQIEMNKKREAefqklRRDLEESTLQHEATAAALRKKQA---DSVAELGEQIDNLQRVKQKLEKEKSEYKMEIDD 1232
Cdd:PRK02224  502 EDLVEAEDRIERLEER-----REDLEELIAERRETIEEKRERAEelrERAAELEAEAEEKREAAAEAEEEAEEAREEVAE 576
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1233 LSSNMEAVAKAKANLEKmcrtLEDQLSEIksknDENLRQINDLSAQRARLQTENGEFGRQLEEKealvsqltrgkqaftq 1312
Cdd:PRK02224  577 LNSKLAELKERIESLER----IRTLLAAI----ADAEDEIERLREKREALAELNDERRERLAEK---------------- 632
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1313 qiEELKRQIEEEVKAKnalahAVQSARHDcdllREQFEEEQEAKAELQRGMSKANSEVaQWRTKYETDAIQRTEELEESK 1392
Cdd:PRK02224  633 --RERKRELEAEFDEA-----RIEEARED----KERAEEYLEQVEEKLDELREERDDL-QAEIGAVENELEELEELRERR 700
                         570       580       590
                  ....*....|....*....|....*....|....
gi 288856329 1393 KKLAQRLqeaeEQIEAVNSKCASLEKTKQRLQGE 1426
Cdd:PRK02224  701 EALENRV----EALEALYDEAEELESMYGDLRAE 730
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
892-1649 2.05e-10

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 66.40  E-value: 2.05e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   892 AVASESENLSDAEERCEGLIKSKIQLEAKLKETTERLEDEEEINAELTAKKRkledecSELKKDIDDLELTLAKVEKEKH 971
Cdd:pfam12128  238 KIRPEFTKLQQEFNTLESAELRLSHLHFGYKSDETLIASRQEERQETSAELN------QLLRTLDDQWKEKRDELNGELS 311
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   972 ATENKVKNLTEEMAAQDESIGKLTKEKKALQEAHQQTLDDLQAE-----------EDKVNTLTKSKTKL-----EQQVDD 1035
Cdd:pfam12128  312 AADAAVAKDRSELEALEDQHGAFLDADIETAAADQEQLPSWQSElenleerlkalTGKHQDVTAKYNRRrskikEQNNRD 391
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1036 LEGSLEQEKKLRMDLERAKRKLEGDLKlAQESIMDLENDKQQSEEKLKKKDFETSQLLSKI--------EDEQSLGAQLQ 1107
Cdd:pfam12128  392 IAGIKDKLAKIREARDRQLAVAEDDLQ-ALESELREQLEAGKLEFNEEEYRLKSRLGELKLrlnqatatPELLLQLENFD 470
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1108 KKIKELQARIEELEEEIEAERAARAKVEKQRADLSRELEEISERLEEAGGATAAQIEMNKKREAEFQKLRR----DLEES 1183
Cdd:pfam12128  471 ERIERAREEQEAANAEVERLQSELRQARKRRDQASEALRQASRRLEERQSALDELELQLFPQAGTLLHFLRkeapDWEQS 550
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1184 TLQHEATAAALR-----------KKQADSVAELG---EQID------NLQRVKQKLEKEKSEYKMEIDDLSSNMEAVAKA 1243
Cdd:pfam12128  551 IGKVISPELLHRtdldpevwdgsVGGELNLYGVKldlKRIDvpewaaSEEELRERLDKAEEALQSAREKQAAAEEQLVQA 630
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1244 KANLEKMCRTLEDQLSEIKSkNDENLRQINDLSAQRAR-----LQTENGEFGRQLEEKEALVSQLTRGKQAFTQQIeelK 1318
Cdd:pfam12128  631 NGELEKASREETFARTALKN-ARLDLRRLFDEKQSEKDkknkaLAERKDSANERLNSLEAQLKQLDKKHQAWLEEQ---K 706
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1319 RQIEEEVKAKNALAHAVQSARHD-CDLLREQFEEEQE-AKAELQRGMSKANSEVAQWRTKYETDAIQRTE--ELEESKKK 1394
Cdd:pfam12128  707 EQKREARTEKQAYWQVVEGALDAqLALLKAAIAARRSgAKAELKALETWYKRDLASLGVDPDVIAKLKREirTLERKIER 786
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1395 LAQRLQEAEE-----------QIEAVNSKCASLEKTKQRLQGEVEDLMIDVERANA--------------LAANLDKKQR 1449
Cdd:pfam12128  787 IAVRRQEVLRyfdwyqetwlqRRPRLATQLSNIERAISELQQQLARLIADTKLRRAklemerkasekqqvRLSENLRGLR 866
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1450 NFDKVLAEWKQKYEEGQAELEGAQKEArslSTELFKMKNSYEEtldqlETLKRENKNLQQEISDLT-EQLGETGKSIHEL 1528
Cdd:pfam12128  867 CEMSKLATLKEDANSEQAQGSIGERLA---QLEDLKLKRDYLS-----ESVKKYVEHFKNVIADHSgSGLAETWESLREE 938
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1529 EKS---KKAVETEKAEIQTALEEAEGTLEHEESKILRVQLELN-QVKSEIDRKLAEKDEEIEQIkrnSQRITDSMQSTLD 1604
Cdd:pfam12128  939 DHYqndKGIRLLDYRKLVPYLEQWFDVRVPQSIMVLREQVSILgVDLTEFYDVLADFDRRIASF---SRELQREVGEEAF 1015
                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....*
gi 288856329  1605 SEvRSRNDALRIKKKMEgdlnemEIQLSHANRQAAEAQKQLRNVQ 1649
Cdd:pfam12128 1016 FE-GVSESAVRIRSKVS------ELEYWPELRVFVKAFRLWKSDG 1053
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1076-1565 3.38e-10

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 65.17  E-value: 3.38e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1076 QQSEEKLKKKDFETSQLLSKIEDEQSLGAQ---LQKKIKELQARIEELEEEIEAERaarakVEKQRADLSRELEEISERL 1152
Cdd:COG4717    74 KELEEELKEAEEKEEEYAELQEELEELEEEleeLEAELEELREELEKLEKLLQLLP-----LYQELEALEAELAELPERL 148
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1153 EEAggataaqiemnKKREAEFQKLRRDLEESTLQHEATAAALRKKQADSVAELGEQIDNLQRVKQKLEKEKSEYKMEIDD 1232
Cdd:COG4717   149 EEL-----------EERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEE 217
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1233 LSSNMEAVAKAKANLEKmcrtlEDQLSEIKSKNDENLRQINDLSAQRARLQTENGEFGRQLEEKEALVSQLtrgkQAFTQ 1312
Cdd:COG4717   218 AQEELEELEEELEQLEN-----ELEAAALEERLKEARLLLLIAAALLALLGLGGSLLSLILTIAGVLFLVL----GLLAL 288
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1313 QIEELKRQieeevkaknalahavqsarhdcdllREQFEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEESK 1392
Cdd:COG4717   289 LFLLLARE-------------------------KASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELL 343
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1393 KKLAQrLQEAEEQIEAVNS--KCASLEKTKQRLQGEVedlmiDVERANALAANLDKKQRnfdkvLAEWKQKYEEGQAELE 1470
Cdd:COG4717   344 DRIEE-LQELLREAEELEEelQLEELEQEIAALLAEA-----GVEDEEELRAALEQAEE-----YQELKEELEELEEQLE 412
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1471 GAQKEARSLSTELfkmknSYEETLDQLETLKRENKNLQQEISDLTEQLGETGKSIHELEKSkkaveTEKAEIQTALEEAE 1550
Cdd:COG4717   413 ELLGELEELLEAL-----DEEELEEELEELEEELEELEEELEELREELAELEAELEQLEED-----GELAELLQELEELK 482
                         490
                  ....*....|....*
gi 288856329 1551 GTLEHEESKILRVQL 1565
Cdd:COG4717   483 AELRELAEEWAALKL 497
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
843-1416 6.02e-10

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 64.81  E-value: 6.02e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   843 KSAETEKELATMKEDFVKCKEDLAKAEAKKKELEEKMVALLQEKNDLQLAVASESENLSDAEERCEGLIKSKIQLEAKLK 922
Cdd:pfam01576  455 KNIKLSKDVSSLESQLQDTQELLQEETRQKLNLSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLE 534
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   923 ETTERLEDEEEIN--------------AELTAKKRKLEDECSELKKDIDDLELTLA------------------------ 964
Cdd:pfam01576  535 EDAGTLEALEEGKkrlqrelealtqqlEEKAAAYDKLEKTKNRLQQELDDLLVDLDhqrqlvsnlekkqkkfdqmlaeek 614
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   965 -----------KVEKEKHATENKVKNLTEEMAAQDESIGKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKSKTKLEQQV 1033
Cdd:pfam01576  615 aisaryaeerdRAEAEAREKETRALSLARALEEALEAKEELERTNKQLRAEMEDLVSSKDDVGKNVHELERSKRALEQQV 694
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1034 DDLEGSLEQEKKLRMDLERAKRKLEGDLK-LAQESIMDLENDKQQSEEKLKKKDFETSQLLSKIEDEQSLGAQ------- 1105
Cdd:pfam01576  695 EEMKTQLEELEDELQATEDAKLRLEVNMQaLKAQFERDLQARDEQGEEKRRQLVKQVRELEAELEDERKQRAQavaakkk 774
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1106 LQKKIKELQARIEELEEEIEAERAARAKVEKQRADLSRELEEISERLEEAGGATAAQIEMNKKREAEFQKLRRDLEESTl 1185
Cdd:pfam01576  775 LELDLKELEAQIDAANKGREEAVKQLKKLQAQMKDLQRELEEARASRDEILAQSKESEKKLKNLEAELLQLQEDLAASE- 853
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1186 QHEATAAALRKKQADSVAELGEQIDNLQRVKQKLEKEKSEYKMEIDDLSSNMEAVAKAKANLEKMCRTLEDQLSEIKSKN 1265
Cdd:pfam01576  854 RARRQAQQERDELADEIASGASGKSALQDEKRRLEARIAQLEEELEEEQSNTELLNDRLRKSTLQVEQLTTELAAERSTS 933
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1266 DENlrqindlSAQRARLQTENGEFGRQLEEKEALV-SQLTRGKQAFTQQIEELKRQIEEEVKAKNALAHAVQSARHDCDL 1344
Cdd:pfam01576  934 QKS-------ESARQQLERQNKELKAKLQEMEGTVkSKFKSSIAALEAKIAQLEEQLEQESRERQAANKLVRRTEKKLKE 1006
                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 288856329  1345 LREQFEEEQEAKAELQRGMSKANSEVAQWRTKYEtDAIQRTEELEESKKKLAQRLQEAEEQIEAVNSKCASL 1416
Cdd:pfam01576 1007 VLLQVEDERRHADQYKDQAEKGNSRMKQLKRQLE-EAEEEASRANAARRKLQRELDDATESNESMNREVSTL 1077
HOOK pfam05622
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from ...
1342-1830 7.18e-10

HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organizms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas this central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head. This entry includes the central coiled-coiled domain and the divergent C-terminal domain.


Pssm-ID: 461694 [Multi-domain]  Cd Length: 528  Bit Score: 63.94  E-value: 7.18e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1342 CDLLREQFEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEesKKKLAQRLQEAEEQIEAVNS----KCASLE 1417
Cdd:pfam05622   16 CHELDQQVSLLQEEKNSLQQENKKLQERLDQLESGDDSGTPGGKKYLL--LQKQLEQLQEENFRLETARDdyriKCEELE 93
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1418 KTKQRLQGEVEDLMIDVERANALAANLDKKQRNFDKVlaewkQKYEegqAELEgaqkearslstelfkmknSYEETLDQL 1497
Cdd:pfam05622   94 KEVLELQHRNEELTSLAEEAQALKDEMDILRESSDKV-----KKLE---ATVE------------------TYKKKLEDL 147
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1498 ETLKRENKNLQQEISDLTEQLGETGKSIHELEKSKKAVETEKAEIQtaleEAEGTLEHEESKILRVQLELNQ-------V 1570
Cdd:pfam05622  148 GDLRRQVKLLEERNAEYMQRTLQLEEELKKANALRGQLETYKRQVQ----ELHGKLSEESKKADKLEFEYKKleekleaL 223
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1571 KSEIDRKLAEKD---EEIEQIK-RNSQRITDSMQSTLDSEVRSRNDALrIKKKMEGDLNEMEIQLSHANRQAAEAQKQlr 1646
Cdd:pfam05622  224 QKEKERLIIERDtlrETNEELRcAQLQQAELSQADALLSPSSDPGDNL-AAEIMPAEIREKLIRLQHENKMLRLGQEG-- 300
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1647 NVQAQLKDAQLHLDDAVRGQEDMKEQVAMVERRNTLMQSEIEELRAALEQTErgrkvaeqelvdaservgllhSQNTSLL 1726
Cdd:pfam05622  301 SYRERLTELQQLLEDANRRKNELETQNRLANQRILELQQQVEELQKALQEQG---------------------SKAEDSS 359
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1727 NTKKKLEADLVQIqSEVEDTVQEARNA-EDKAKKAITDAAMMAEEL-----KKEQDTSAHLERMKKNLE---VTVKDLQH 1797
Cdd:pfam05622  360 LLKQKLEEHLEKL-HEAQSELQKKKEQiEELEPKQDSNLAQKIDELqealrKKDEDMKAMEERYKKYVEkakSVIKTLDP 438
                          490       500       510
                   ....*....|....*....|....*....|...
gi 288856329  1798 RLDEAENLAMKGGKKQLQKLESRVRELESEVEA 1830
Cdd:pfam05622  439 KQNPASPPEIQALKNQLLEKDKKIEHLERDFEK 471
PRK01156 PRK01156
chromosome segregation protein; Provisional
920-1502 7.22e-10

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 64.15  E-value: 7.22e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  920 KLKETTERLEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAAQDESIGKLT---K 996
Cdd:PRK01156  170 KLKDVIDMLRAEISNIDYLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNNLKSALNELSsleD 249
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  997 EKKALQEAHQQTLDDLQAEEDKVNTLTKSKTKLEQQVDD--------------LEGSLEQEKKLRMDLERAKRKLEGDLK 1062
Cdd:PRK01156  250 MKNRYESEIKTAESDLSMELEKNNYYKELEERHMKIINDpvyknrnyindyfkYKNDIENKKQILSNIDAEINKYHAIIK 329
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1063 LAQesimDLENDKQQSEEKLKKKDFETSQLLSKIEDE---QSLGAQLQKKIKELQARIEELEEEIEAERAARAKVEKQRA 1139
Cdd:PRK01156  330 KLS----VLQKDYNDYIKKKSRYDDLNNQILELEGYEmdyNSYLKSIESLKKKIEEYSKNIERMSAFISEILKIQEIDPD 405
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1140 DLSRELEEISERLEEAGGATAAqieMNKKREAefqkLRRDLEEstLQHEATAAALRKKQADSVAELGEqiDNLQRVKQKL 1219
Cdd:PRK01156  406 AIKKELNEINVKLQDISSKVSS---LNQRIRA----LRENLDE--LSRNMEMLNGQSVCPVCGTTLGE--EKSNHIINHY 474
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1220 EKEKSEYKMEIDDLSSNMEAVAKAKANLEKMCRTLEdqlseiKSKNDENLRQINDLSAQRArlqtengefgrQLEEKEAL 1299
Cdd:PRK01156  475 NEKKSRLEEKIREIEIEVKDIDEKIVDLKKRKEYLE------SEEINKSINEYNKIESARA-----------DLEDIKIK 537
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1300 VSQLTRGKQAFTQQIEELKRQIEEEVKAKNALAHAVQSARH--DCDLLREQFEEEQEAKAELQRGMSKANSEVAQWRTkY 1377
Cdd:PRK01156  538 INELKDKHDKYEEIKNRYKSLKLEDLDSKRTSWLNALAVISliDIETNRSRSNEIKKQLNDLESRLQEIEIGFPDDKS-Y 616
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1378 ETDAIQRTEELEESKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQGEVEDLMIDVERANALAANLDKKQRNFDKVLAE 1457
Cdd:PRK01156  617 IDKSIREIENEANNLNNKYNEIQENKILIEKLRGKIDNYKKQIAEIDSIIPDLKEITSRINDIEDNLKKSRKALDDAKAN 696
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*
gi 288856329 1458 wkqkyeegQAELEGAQKEARSLSTELFKMKNSYEETLDQLETLKR 1502
Cdd:PRK01156  697 --------RARLESTIEILRTRINELSDRINDINETLESMKKIKK 733
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1502-1916 8.22e-10

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 64.02  E-value: 8.22e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1502 RENKNLQQEISDLTEQLGEtgksIHELEKSKKAVETEKAEIQTALEEAEGtlEHEESKILRVQLELNQVKSEIDRKLAEK 1581
Cdd:COG4717    71 KELKELEEELKEAEEKEEE----YAELQEELEELEEELEELEAELEELRE--ELEKLEKLLQLLPLYQELEALEAELAEL 144
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1582 DEEIEQIKRNSQRITDSMQSTLDSEVRSRNDALRIKKKMEGDLNEMEIQLSHANRQAAEAQKQLRNVQAQLKDAQLHLDD 1661
Cdd:COG4717   145 PERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEE 224
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1662 AvrgqedmkeqvamverrntlmQSEIEELRAALEQTERGRKVAEQE--LVDASERVGLLHSQNTSLLNTKKKLEADLVQI 1739
Cdd:COG4717   225 L---------------------EEELEQLENELEAAALEERLKEARllLLIAAALLALLGLGGSLLSLILTIAGVLFLVL 283
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1740 QSEVEDTVQEARNAEDKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEVTVKDLQHRLDEAENLamKGGKKQLQKLES 1819
Cdd:COG4717   284 GLLALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEEL--QELLREAEELEE 361
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1820 RVRELESEVEAEQ-------------RRGADAVKGVRKYERRVKELTYQTEEDKKNVNRLQDLVDKLQLKVKA--YKRQS 1884
Cdd:COG4717   362 ELQLEELEQEIAAllaeagvedeeelRAALEQAEEYQELKEELEELEEQLEELLGELEELLEALDEEELEEELeeLEEEL 441
                         410       420       430
                  ....*....|....*....|....*....|..
gi 288856329 1885 EEAEEQANSHLSKLRKVQHELEEAEERADIAE 1916
Cdd:COG4717   442 EELEEELEELREELAELEAELEQLEEDGELAE 473
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
1079-1776 1.18e-09

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 63.59  E-value: 1.18e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1079 EEKLKKKDFETSQLLSKIEDEQSLGAQlqkKIKELQARIEELEEEIEAERAARAKV-EKQRA---DLSRELEEISERLEE 1154
Cdd:pfam05483   62 QEGLKDSDFENSEGLSRLYSKLYKEAE---KIKKWKVSIEAELKQKENKLQENRKIiEAQRKaiqELQFENEKVSLKLEE 138
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1155 AGGATAAQIEMNKKREAEFQKLRRDLE---ESTLQHEATAAALRKKQADSVAELGEQIDNLQRVKQKLEKEKSEYKMEid 1231
Cdd:pfam05483  139 EIQENKDLIKENNATRHLCNLLKETCArsaEKTKKYEYEREETRQVYMDLNNNIEKMILAFEELRVQAENARLEMHFK-- 216
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1232 dLSSNMEAVAKAKANLEKMCRTLEDQLSEIKSKNDENLRQINDLSAqrarLQTENGEFGRQLEEKEALVS----QLTRGK 1307
Cdd:pfam05483  217 -LKEDHEKIQHLEEEYKKEINDKEKQVSLLLIQITEKENKMKDLTF----LLEESRDKANQLEEKTKLQDenlkELIEKK 291
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1308 QAFTQQIEELKRQIEEEVKAKNALAHAVQSA-RHDCDLLRE---QFEEEQEAKAELQRGMSKANSEVAQWRTKYETDAiQ 1383
Cdd:pfam05483  292 DHLTKELEDIKMSLQRSMSTQKALEEDLQIAtKTICQLTEEkeaQMEELNKAKAAHSFVVTEFEATTCSLEELLRTEQ-Q 370
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1384 RTEELEESKKKLAQRLQ----EAEEQIEAVNSKCASLEKTKQRLqGEVEDLMidveranalaanldKKQRNFDKVLAEWK 1459
Cdd:pfam05483  371 RLEKNEDQLKIITMELQkkssELEEMTKFKNNKEVELEELKKIL-AEDEKLL--------------DEKKQFEKIAEELK 435
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1460 QKYEEGQAELEGAQKEARSLSTELFKMKNSYEETLDQLETLKRENKNLQQEISDLTEQlgetgksihelekskkavetek 1539
Cdd:pfam05483  436 GKEQELIFLLQAREKEIHDLEIQLTAIKTSEEHYLKEVEDLKTELEKEKLKNIELTAH---------------------- 493
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1540 aeiqtaleeaegtleheESKILRVQLELNQVKSEIDRKLAEKDEEIEQIKRNSQRITDSMQSTLDSEVRSRNDALRIKKK 1619
Cdd:pfam05483  494 -----------------CDKLLLENKELTQEASDMTLELKKHQEDIINCKKQEERMLKQIENLEEKEMNLRDELESVREE 556
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1620 MEGDLNEMEIQLSHANRQAAEAQKQLRNVQAQLKDAQLHLDDAVRGQEDMKEQVAMVERRNTLMQSEIEELRAALEQTER 1699
Cdd:pfam05483  557 FIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKCNNLKKQIENKNKNIEELHQENKALKKKGSAENKQLNAYEI 636
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1700 GRKVAEQELVDASERVGLLHSQNTSLLNTKKKLEADLVQIQSEVEDTVQEA----RNAEDKAKKAITDAAMMAEELKKEQ 1775
Cdd:pfam05483  637 KVNKLELELASAKQKFEEIIDNYQKEIEDKKISEEKLLEEVEKAKAIADEAvklqKEIDKRCQHKIAEMVALMEKHKHQY 716

                   .
gi 288856329  1776 D 1776
Cdd:pfam05483  717 D 717
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
845-1267 1.19e-09

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 63.54  E-value: 1.19e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  845 AETEKELATMKEDfVKCKEDLAKAEAKKKELEEKMVALLQEKNDLQLAVASESENLSDAEERCEGLIKSKIQLE---AKL 921
Cdd:PRK03918  269 EELKKEIEELEEK-VKELKELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEelkKKL 347
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  922 KETTERLEDEEEiNAELTAKKRKLEDECSELKK-----DIDDLELTLAKVEKEKHATENKVKNLTEEMAAQDESIGKLTK 996
Cdd:PRK03918  348 KELEKRLEELEE-RHELYEEAKAKKEELERLKKrltglTPEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKK 426
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  997 EKKALQEAHQQ--TLDDLQAEEDKVNTLTKSKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQE-------- 1066
Cdd:PRK03918  427 AIEELKKAKGKcpVCGRELTEEHRKELLEEYTAELKRIEKELKEIEEKERKLRKELRELEKVLKKESELIKLkelaeqlk 506
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1067 ------SIMDLENDKQQSE--EKLKKKDFETSQLLSKIEDEQSLGAQLQKKIKELQarieeleeeieaerAARAKVEKQR 1138
Cdd:PRK03918  507 eleeklKKYNLEELEKKAEeyEKLKEKLIKLKGEIKSLKKELEKLEELKKKLAELE--------------KKLDELEEEL 572
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1139 ADLSREL--------EEISERLEEAGGATAAQIEM-NKKREAEFQKLRRDLEESTLqhEATAAALRKKQADsVAELGEQI 1209
Cdd:PRK03918  573 AELLKELeelgfesvEELEERLKELEPFYNEYLELkDAEKELEREEKELKKLEEEL--DKAFEELAETEKR-LEELRKEL 649
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 288856329 1210 DNLQRV-----KQKLEKEKSEYKMEIDDLSSNMEAVAKAKANLEKMCRTLEDQLSEIKSKNDE 1267
Cdd:PRK03918  650 EELEKKyseeeYEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEEREKAKKE 712
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
916-1244 1.69e-09

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 62.61  E-value: 1.69e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   916 QLEAKLKETTERLEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAAQDESIGKLT 995
Cdd:pfam07888   35 RLEECLQERAELLQAQEAANRQREKEKERYKRDREQWERQRRELESRVAELKEELRQSREKHEELEEKYKELSASSEELS 114
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   996 KEKKALQEAHQQTLDDLQAEEDKVNTLTKSKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDLENDK 1075
Cdd:pfam07888  115 EEKDALLAQRAAHEARIRELEEDIKTLTQRVLERETELERMKERAKKAGAQRKEEEAERKQLQAKLQQTEEELRSLSKEF 194
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1076 QQSEEKLKKKDFETSQLLSKIEDEQSLGAQLQKKIKELQARIEELEEEIEAERAARAKVEKQRADLSR------------ 1143
Cdd:pfam07888  195 QELRNSLAQRDTQVLQLQDTITTLTQKLTTAHRKEAENEALLEELRSLQERLNASERKVEGLGEELSSmaaqrdrtqael 274
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1144 -----ELEEISERLEEA------GGATAAQ--------IEMNKKR----EAEFQKLRRDLEESTLQHEATAAAL------ 1194
Cdd:pfam07888  275 hqarlQAAQLTLQLADAslalreGRARWAQeretlqqsAEADKDRieklSAELQRLEERLQEERMEREKLEVELgrekdc 354
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....
gi 288856329  1195 -RKKQADSVAELGEQIDNL---QRVKQKLEKEKSEYKMEIDDLSSNMEAVAKAK 1244
Cdd:pfam07888  355 nRVQLSESRRELQELKASLrvaQKEKEQLQAEKQELLEYIRQLEQRLETVADAK 408
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1460-1679 1.72e-09

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 62.09  E-value: 1.72e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1460 QKYEEGQAELEGAQKEARSLSTELFKMKNSYEETLDQLETLKRENKNLQQEISDLTEQLGETGKSIHELEKSKKAVETEK 1539
Cdd:COG4942    20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1540 AEIQTALEEAEGTLeHEESKILRVQLELNQVKSEidrKLAEKDEEIEQIKRNSQRITDSMQSTLDSEVRSRNDALRIKKK 1619
Cdd:COG4942   100 EAQKEELAELLRAL-YRLGRQPPLALLLSPEDFL---DAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAE 175
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1620 MEGDLNEMEIQLSHANRQAAEAQKQLRNVQAQLKDAQLHLDDAVRGQEDMKEQVAMVERR 1679
Cdd:COG4942   176 LEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAE 235
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
1399-1610 2.13e-09

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 61.77  E-value: 2.13e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1399 LQEAEEQIEAVNSKCASLEKTKQRLQGEVEDLMIDVERANALAANLDKKQRNFDKVLAEWKQKYEEGQAELEG----AQK 1474
Cdd:COG3883    18 IQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGEraraLYR 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1475 EARSLST-ELFKMKNSYEETLDQLETLKRENKNLQQEISDLTEQLGEtgksiheLEKSKKAVETEKAEIQTALEEAEGTL 1553
Cdd:COG3883    98 SGGSVSYlDVLLGSESFSDFLDRLSALSKIADADADLLEELKADKAE-------LEAKKAELEAKLAELEALKAELEAAK 170
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 288856329 1554 EHEESKILRVQLELNQVKSEIDRKLAEKDEEIEQIKRNSQRITDSMQSTLDSEVRSR 1610
Cdd:COG3883   171 AELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAA 227
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
916-1116 2.22e-09

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 61.70  E-value: 2.22e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  916 QLEAKLKETTERLEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAAQDESIGKLT 995
Cdd:COG4942    24 EAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQK 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  996 KEKK----ALQEAHQQTLDDLQAEEDKVNTLTKSKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDL 1071
Cdd:COG4942   104 EELAellrALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAEL 183
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 288856329 1072 ENDKQQSEEKLKKKDFETSQLLSKIEDEQSLGAQLQKKIKELQAR 1116
Cdd:COG4942   184 EEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEAL 228
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
918-1692 2.87e-09

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 62.66  E-value: 2.87e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  918 EAKLKETTERLEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEkekhatenkvknltEEMAAQDESIGKLTKE 997
Cdd:COG3096   353 QEDLEELTERLEEQEEVVEEAAEQLAEAEARLEAAEEEVDSLKSQLADYQ--------------QALDVQQTRAIQYQQA 418
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  998 KKALQEAHQQT-LDDLqAEEDKVNTLTKSKTKLEQQVDDLegsLEQEKKLRMDlERAKRKLEGDLKL------------- 1063
Cdd:COG3096   419 VQALEKARALCgLPDL-TPENAEDYLAAFRAKEQQATEEV---LELEQKLSVA-DAARRQFEKAYELvckiageversqa 493
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1064 ---AQESIMDLENDKQQSE--EKLKKKDFETSQLLSKIEDEQSLGAQLQKKIKElqarieeleeeieaERAARAKVEKQR 1138
Cdd:COG3096   494 wqtARELLRRYRSQQALAQrlQQLRAQLAELEQRLRQQQNAERLLEEFCQRIGQ--------------QLDAAEELEELL 559
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1139 ADLSRELEEISERLEEAGgatAAQIEMNKKREaEFQKLRRDLEESTLQHEATAAALRKKQAdsvaELGEQIDNLQRV--- 1215
Cdd:COG3096   560 AELEAQLEELEEQAAEAV---EQRSELRQQLE-QLRARIKELAARAPAWLAAQDALERLRE----QSGEALADSQEVtaa 631
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1216 -KQKLEKEKsEYKMEIDDLssnmeavAKAKANLEKMCRTL------EDQ-------------LSEIK---SKNDE----- 1267
Cdd:COG3096   632 mQQLLERER-EATVERDEL-------AARKQALESQIERLsqpggaEDPrllalaerlggvlLSEIYddvTLEDApyfsa 703
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1268 ---NLRQ---INDLSAQRARLQT-----------------------ENGEFGR----QLEEKEALVSQLTR----GKQAF 1310
Cdd:COG3096   704 lygPARHaivVPDLSAVKEQLAGledcpedlyliegdpdsfddsvfDAEELEDavvvKLSDRQWRYSRFPEvplfGRAAR 783
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1311 TQQIEELKRQIEEEVKAKNALAHAVQS------------ARHDCDLLREQFEEE----QEAKAELQRGMSKANSEVAQWR 1374
Cdd:COG3096   784 EKRLEELRAERDELAEQYAKASFDVQKlqrlhqafsqfvGGHLAVAFAPDPEAElaalRQRRSELERELAQHRAQEQQLR 863
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1375 TKYEtdaiQRTEELEESKK-----------KLAQRLQEAEEQIEAVNSKCASLEKTKQRLqGEVEDlmidveranaLAAN 1443
Cdd:COG3096   864 QQLD----QLKEQLQLLNKllpqanlladeTLADRLEELREELDAAQEAQAFIQQHGKAL-AQLEP----------LVAV 928
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1444 LDKKQRNFDKVlaewKQKYEEGQAELEGAQKEARSLsTELFKMKN--SYEETLDQLEtlkrenknlqqEISDLTEQLGEt 1521
Cdd:COG3096   929 LQSDPEQFEQL----QADYLQAKEQQRRLKQQIFAL-SEVVQRRPhfSYEDAVGLLG-----------ENSDLNEKLRA- 991
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1522 gksihELEKskkaVETEKAEIQTALEEAEGtlEHEESkiLRVQLELN---QVKSEIdrkLAEKDEEIEQIkrnSQRITDS 1598
Cdd:COG3096   992 -----RLEQ----AEEARREAREQLRQAQA--QYSQY--NQVLASLKssrDAKQQT---LQELEQELEEL---GVQADAE 1052
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1599 MQSTLDSEVRSRNDALRIKKkmeGDLNEMEIQLSHANRQAAEAQKQLRNVQAQLKDAQLHLDDAVRGQEDMKEQVAM--V 1676
Cdd:COG3096  1053 AEERARIRRDELHEELSQNR---SRRSQLEKQLTRCEAEMDSLQKRLRKAERDYKQEREQVVQAKAGWCAVLRLARDndV 1129
                         890       900
                  ....*....|....*....|.
gi 288856329 1677 ERRntLMQSEI-----EELRA 1692
Cdd:COG3096  1130 ERR--LHRRELaylsaDELRS 1148
mukB PRK04863
chromosome partition protein MukB;
997-1855 2.91e-09

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 62.67  E-value: 2.91e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  997 EKKALQEAHQQTLDDLQAEEDkvnTLTKSKTKLEQQVDDLEGSL----------EQEKKLRMDLERAKRKLEGDL---KL 1063
Cdd:PRK04863  297 TSRRQLAAEQYRLVEMARELA---ELNEAESDLEQDYQAASDHLnlvqtalrqqEKIERYQADLEELEERLEEQNevvEE 373
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1064 AQESIMDLENDKQQSEEklkkkdfETSQLLSKIED-EQSLGAQLQKKIKELQARIEELeeeieaeraaraKVEKQRADLS 1142
Cdd:PRK04863  374 ADEQQEENEARAEAAEE-------EVDELKSQLADyQQALDVQQTRAIQYQQAVQALE------------RAKQLCGLPD 434
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1143 RELEEISERLEEAggATAAQIEMNKKREAEfQKLRrDLEESTLQHEATAAALRKkqadsvaeLGEQID--NLQRVKQKLE 1220
Cdd:PRK04863  435 LTADNAEDWLEEF--QAKEQEATEELLSLE-QKLS-VAQAAHSQFEQAYQLVRK--------IAGEVSrsEAWDVARELL 502
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1221 KEKSEYKMEIDDLSSnmeavakAKANLEKMCRTLEDQLSEIKSKNDENLRQINDLSAQrARLQTENGEFGRQLEEKEALV 1300
Cdd:PRK04863  503 RRLREQRHLAEQLQQ-------LRMRLSELEQRLRQQQRAERLLAEFCKRLGKNLDDE-DELEQLQEELEARLESLSESV 574
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1301 SQLTRGKQAFTQQIEELKRQIEEeVKAKNALAHAVQSArhdCDLLREQFEEEQEAKAELQRGMSkansevaqwrtkyetD 1380
Cdd:PRK04863  575 SEARERRMALRQQLEQLQARIQR-LAARAPAWLAAQDA---LARLREQSGEEFEDSQDVTEYMQ---------------Q 635
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1381 AIQRTEELEESKKKLAQRLQEAEEQIEAVNSKCAS----LEKTKQRLQGE-VEDLMIDVERANA--------------LA 1441
Cdd:PRK04863  636 LLERERELTVERDELAARKQALDEEIERLSQPGGSedprLNALAERFGGVlLSEIYDDVSLEDApyfsalygparhaiVV 715
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1442 ANLDKKQRNFDKvlaewkqkyEEGQAE----LEG---AQKEARSLSTELFK----------MKNSYEETLDQLETLKREN 1504
Cdd:PRK04863  716 PDLSDAAEQLAG---------LEDCPEdlylIEGdpdSFDDSVFSVEELEKavvvkiadrqWRYSRFPEVPLFGRAAREK 786
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1505 --KNLQQEISDLTEQLGETGKSIHELEKSKKAV----------------ETEKAEIQTALEEAEGTLEHEESKILRVQLE 1566
Cdd:PRK04863  787 riEQLRAEREELAERYATLSFDVQKLQRLHQAFsrfigshlavafeadpEAELRQLNRRRVELERALADHESQEQQQRSQ 866
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1567 LNQVKSEID--RKLAEK---------DEEIEQIKRNSQRITDSMQStldseVRSRNDALRIKKKMEGDLNEMEIQLSHAN 1635
Cdd:PRK04863  867 LEQAKEGLSalNRLLPRlnlladetlADRVEEIREQLDEAEEAKRF-----VQQHGNALAQLEPIVSVLQSDPEQFEQLK 941
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1636 RQAAEAQKQLRNVQAQLKDaqlhLDDAVRGQEDMK--EQVAMVERRNTLmqseIEELRAALEQTERGRKVAEQELVDASE 1713
Cdd:PRK04863  942 QDYQQAQQTQRDAKQQAFA----LTEVVQRRAHFSyeDAAEMLAKNSDL----NEKLRQRLEQAEQERTRAREQLRQAQA 1013
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1714 RvgllHSQNTSLLntkkkleADLVQIQSEVEDTVQEA-RNAEDKAKKAITDAAMMAEELKKEQDTSAHLERMKKN-LEvt 1791
Cdd:PRK04863 1014 Q----LAQYNQVL-------ASLKSSYDAKRQMLQELkQELQDLGVPADSGAEERARARRDELHARLSANRSRRNqLE-- 1080
                         890       900       910       920       930       940
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 288856329 1792 vkdLQHRLDEAEnlaMKGGKKQLQKLESRVRELESEVEAEQRRGADAVKGVRKY--ERRV--KELTYQ 1855
Cdd:PRK04863 1081 ---KQLTFCEAE---MDNLTKKLRKLERDYHEMREQVVNAKAGWCAVLRLVKDNgvERRLhrRELAYL 1142
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
944-1531 4.78e-09

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 61.99  E-value: 4.78e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   944 KLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAAQDESI------GKLTKEKKALQEAHQQTLDDLQAEED 1017
Cdd:TIGR00606  581 SKSKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDKLfdvcgsQDEESDLERLKEEIEKSSKQRAMLAG 660
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1018 KVNTLTKSKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQesimdlenDKQQSEEK-LKKKDFETSQLLSKI 1096
Cdd:TIGR00606  661 ATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEFISDLQSKLRLAP--------DKLKSTESeLKKKEKRRDEMLGLA 732
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1097 EDEQSLGAQLQKKIKELQarieeleeeieaeraarAKVEKQRADLSRELEEISERlEEAGGATAAQIEMNKKREAEFQKL 1176
Cdd:TIGR00606  733 PGRQSIIDLKEKEIPELR-----------------NKLQKVNRDIQRLKNDIEEQ-ETLLGTIMPEEESAKVCLTDVTIM 794
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1177 RRdLEESTLQHEataaalrKKQADSVAELgeQIDNLQRVKQKLEKEKSEYKMEIDDLSSNMEAVAKAKANLEKMCRTLED 1256
Cdd:TIGR00606  795 ER-FQMELKDVE-------RKIAQQAAKL--QGSDLDRTVQQVNQEKQEKQHELDTVVSKIELNRKLIQDQQEQIQHLKS 864
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1257 QLSEIKSKN---DENLRQINDLSAQRARLQTENGEFGRQLEEKEALVSQLTRGKQAFTQQIEEL-KRQIEEEVKAKNALA 1332
Cdd:TIGR00606  865 KTNELKSEKlqiGTNLQRRQQFEEQLVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELiSSKETSNKKAQDKVN 944
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1333 HAVQSARHDCDLLREQFEEEQEAKAELQR-------GMSKANSEVAQWRTKYETDAIQRTEELEESKKKlaQRLQEAEEQ 1405
Cdd:TIGR00606  945 DIKEKVKNIHGYMKDIENKIQDGKDDYLKqketelnTVNAQLEECEKHQEKINEDMRLMRQDIDTQKIQ--ERWLQDNLT 1022
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1406 IEAVNSKCASLEKTKQRLQGEVEDLMIDVERA--NALAANLDKKQRNFDKVLAEwKQKYEEgqaELEGAQKEARslSTEL 1483
Cdd:TIGR00606 1023 LRKRENELKEVEEELKQHLKEMGQMQVLQMKQehQKLEENIDLIKRNHVLALGR-QKGYEK---EIKHFKKELR--EPQF 1096
                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 288856329  1484 FKMKNSYEETLDQLETLKRENKNL--------QQEISDLTEQLGETGKSIHELEKS 1531
Cdd:TIGR00606 1097 RDAEEKYREMMIVMRTTELVNKDLdiyyktldQAIMKFHSMKMEEINKIIRDLWRS 1152
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1293-1911 5.68e-09

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 61.47  E-value: 5.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1293 LEEKE------ALVSQLTRGKQAFtQQIEELKRQIEeevkaknALAHAVQSArhdcdllrEQFEEEQEAKAELQRGMSKA 1366
Cdd:COG4913   218 LEEPDtfeaadALVEHFDDLERAH-EALEDAREQIE-------LLEPIRELA--------ERYAAARERLAELEYLRAAL 281
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1367 NSEVAQwrTKYETdAIQRTEELEESKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQGE-VEDLMIDVERANALAANLD 1445
Cdd:COG4913   282 RLWFAQ--RRLEL-LEAELEELRAELARLEAELERLEARLDALREELDELEAQIRGNGGDrLEQLEREIERLERELEERE 358
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1446 KKQRNFDKVLAEWKQKYEEGQAELEGAQKEARSLSTELfkmknsyeetldqletlkrenknlQQEISDLTEQLGETGKSI 1525
Cdd:COG4913   359 RRRARLEALLAALGLPLPASAEEFAALRAEAAALLEAL------------------------EEELEALEEALAEAEAAL 414
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1526 HELEKSKKAVETEKAEIQtaleeaegtleheeskilrvqlelnQVKSEIDRKL--------------------------- 1578
Cdd:COG4913   415 RDLRRELRELEAEIASLE-------------------------RRKSNIPARLlalrdalaealgldeaelpfvgeliev 469
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1579 AEKDEE-----------------------------IEQIKrNSQRI-TDSMQSTLDSEVRSRNDALRIKKKMEGDLN--- 1625
Cdd:COG4913   470 RPEEERwrgaiervlggfaltllvppehyaaalrwVNRLH-LRGRLvYERVRTGLPDPERPRLDPDSLAGKLDFKPHpfr 548
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1626 ---EMEIQlSHANRQAAEAQKQLRNVQAQL-KDAQLHlDDAVRGQEDMKEQVAmveRRNTLMQS---EIEELRAALEQTE 1698
Cdd:COG4913   549 awlEAELG-RRFDYVCVDSPEELRRHPRAItRAGQVK-GNGTRHEKDDRRRIR---SRYVLGFDnraKLAALEAELAELE 623
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1699 RGRKVAEQELVDASERVGLLHSQNTSLLNTKKKLEA--DLVQIQSEVEDtVQEARNAEDKAKKAITDAAMMAEELKKEQD 1776
Cdd:COG4913   624 EELAEAEERLEALEAELDALQERREALQRLAEYSWDeiDVASAEREIAE-LEAELERLDASSDDLAALEEQLEELEAELE 702
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1777 TsahLERMKKNLEVTVKDLQHRLDEAEnlamkggkKQLQKLESRVRELESEVEAEQRRGADAVKGVRKYERRVKELTYQT 1856
Cdd:COG4913   703 E---LEEELDELKGEIGRLEKELEQAE--------EELDELQDRLEAAEDLARLELRALLEERFAAALGDAVERELRENL 771
                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 288856329 1857 EED-KKNVNRLQDLVDKLQLKVKAYKRQ----------SEEAEEQANSHLSKLRkvQHELEEAEER 1911
Cdd:COG4913   772 EERiDALRARLNRAEEELERAMRAFNREwpaetadldaDLESLPEYLALLDRLE--EDGLPEYEER 835
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
991-1426 1.01e-08

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 60.17  E-value: 1.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  991 IGKLTKEKKAL--------------QEAHQQTLDDLQAEEDKVNTLTKSKTKLEQQVDDLEGSLEQEKKLRMDLERAKRK 1056
Cdd:COG4717    48 LERLEKEADELfkpqgrkpelnlkeLKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQL 127
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1057 LE--GDLKLAQESIMDLENDKQQSEEKLKkkdfETSQLLSKIEDEQSLGAQLQKKIKEL-QARIEELEEEIEAERAARAK 1133
Cdd:COG4717   128 LPlyQELEALEAELAELPERLEELEERLE----ELRELEEELEELEAELAELQEELEELlEQLSLATEEELQDLAEELEE 203
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1134 VEKQRADLSRELEEISERLEEAGGATaAQIEMNKKREAEFQKLRR------------------DLEESTLQHEATAAALR 1195
Cdd:COG4717   204 LQQRLAELEEELEEAQEELEELEEEL-EQLENELEAAALEERLKEarlllliaaallallglgGSLLSLILTIAGVLFLV 282
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1196 --------KKQADSVAELGEQIDNLQRVKQKLEKEKSEYKMEIDDLSSNMEAVAKAKANLEKMCRTLEDQLSEIKSKNDE 1267
Cdd:COG4717   283 lgllallfLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEE 362
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1268 nlRQINDLSAQRARLQTENGefgrqLEEKEALVSQLTRGKQAftQQIEELKRQIEEEVKAKNALAHAvQSARHDCDLLRE 1347
Cdd:COG4717   363 --LQLEELEQEIAALLAEAG-----VEDEEELRAALEQAEEY--QELKEELEELEEQLEELLGELEE-LLEALDEEELEE 432
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1348 QFEEEQEAKAELQRGMSKANSEVAqwRTKYETDAIQRTEELEESKKKLAQ---RLQEAEEQIEAVNSKCASLEKTKQRLQ 1424
Cdd:COG4717   433 ELEELEEELEELEEELEELREELA--ELEAELEQLEEDGELAELLQELEElkaELRELAEEWAALKLALELLEEAREEYR 510

                  ..
gi 288856329 1425 GE 1426
Cdd:COG4717   511 EE 512
mukB PRK04863
chromosome partition protein MukB;
916-1697 1.07e-08

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 60.74  E-value: 1.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  916 QLEAKLKETTERLEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEkekhatenkvknltEEMAAQDESIGKLT 995
Cdd:PRK04863  352 RYQADLEELEERLEEQNEVVEEADEQQEENEARAEAAEEEVDELKSQLADYQ--------------QALDVQQTRAIQYQ 417
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  996 KEKKALQEAHQQT-LDDLQAE--EDKVNTLTKSKTKLEQQVDDLEGSLEQEKKLRMDLERAK---RKLEGDL------KL 1063
Cdd:PRK04863  418 QAVQALERAKQLCgLPDLTADnaEDWLEEFQAKEQEATEELLSLEQKLSVAQAAHSQFEQAYqlvRKIAGEVsrseawDV 497
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1064 AQESIMDLENDKQQSE--EKLKKKDFETSQLLSKIEDEQSLGAQLQKKikelqarieeleeeIEAERAARAKVEKQRADL 1141
Cdd:PRK04863  498 ARELLRRLREQRHLAEqlQQLRMRLSELEQRLRQQQRAERLLAEFCKR--------------LGKNLDDEDELEQLQEEL 563
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1142 SRELEEISERLEEAGgatAAQIEMNKKREaefqklrrDLEESTLQHEATAAALRKKQaDSVAELGEQ----IDNLQRV-- 1215
Cdd:PRK04863  564 EARLESLSESVSEAR---ERRMALRQQLE--------QLQARIQRLAARAPAWLAAQ-DALARLREQsgeeFEDSQDVte 631
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1216 --KQKLEKEKsEYKMEIDDLSSNMEAV--------AKAKANLEKMcRTLEDQ-----LSEIKSknDENL----------- 1269
Cdd:PRK04863  632 ymQQLLERER-ELTVERDELAARKQALdeeierlsQPGGSEDPRL-NALAERfggvlLSEIYD--DVSLedapyfsalyg 707
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1270 --RQ---INDLSAQRARLQTE------------------NGEFGRQLEEKEALVSQLTR-------------GKQAFTQQ 1313
Cdd:PRK04863  708 paRHaivVPDLSDAAEQLAGLedcpedlyliegdpdsfdDSVFSVEELEKAVVVKIADRqwrysrfpevplfGRAAREKR 787
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1314 IEELKRQIEEEVKAKNALAHAVQsarhDCDLLREQFEE--------------EQEAKA------ELQRGMSKANSEVAQW 1373
Cdd:PRK04863  788 IEQLRAEREELAERYATLSFDVQ----KLQRLHQAFSRfigshlavafeadpEAELRQlnrrrvELERALADHESQEQQQ 863
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1374 RTKYET--DAIQRTEELEESKK-----KLAQRLQEAEEQIEAVNSKCASLEKTKQRLqgevedlmidvERANALAANLDK 1446
Cdd:PRK04863  864 RSQLEQakEGLSALNRLLPRLNlladeTLADRVEEIREQLDEAEEAKRFVQQHGNAL-----------AQLEPIVSVLQS 932
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1447 KQRNFDKVlaewKQKYEEGQAELEGAQKEARSLsTELFKMKN--SYEETLDQLEtlkrenknlqqEISDLTEQLGetgks 1524
Cdd:PRK04863  933 DPEQFEQL----KQDYQQAQQTQRDAKQQAFAL-TEVVQRRAhfSYEDAAEMLA-----------KNSDLNEKLR----- 991
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1525 ihelEKSKKAvETEKAEIQTALEEAEGTLeheeSKILRVQLELnqvKSEIDRKLAEKDEEIEQIKRNSQRITDSMQSTLD 1604
Cdd:PRK04863  992 ----QRLEQA-EQERTRAREQLRQAQAQL----AQYNQVLASL---KSSYDAKRQMLQELKQELQDLGVPADSGAEERAR 1059
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1605 SEVRSRNDALRIKKkmeGDLNEMEIQLSHANRQAAEAQKQLRNVQAQLKDAQLHLDDAVRGQEDMKEQVAM--VERRntL 1682
Cdd:PRK04863 1060 ARRDELHARLSANR---SRRNQLEKQLTFCEAEMDNLTKKLRKLERDYHEMREQVVNAKAGWCAVLRLVKDngVERR--L 1134
                         890       900
                  ....*....|....*....|
gi 288856329 1683 MQSEI-----EELRAALEQT 1697
Cdd:PRK04863 1135 HRRELaylsaDELRSMSDKA 1154
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1064-1281 1.16e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 59.39  E-value: 1.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1064 AQESIMDLENDKQQSEEKLKKKDFETSQLLSKIEDEQSLGAQLQKKIKELQARIEELEEEIEAERAARAKVEKQRADLSR 1143
Cdd:COG4942    18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRA 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1144 ELEEISERLEE-------AGGATAAQIEMNKKREAEFQKLRRDLEESTLQHEATAAALRKKQadsvAELGEQIDNLQRVK 1216
Cdd:COG4942    98 ELEAQKEELAEllralyrLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADL----AELAALRAELEAER 173
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 288856329 1217 QKLEKEKSEYKMEIDDLSSNMEAVAKAKANLEKMCRTLEDQLSEIKSKNDENLRQINDLSAQRAR 1281
Cdd:COG4942   174 AELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAA 238
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
913-1642 1.21e-08

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 60.45  E-value: 1.21e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   913 SKIQLEAKLKETTERLEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAAQDESIG 992
Cdd:TIGR00606  350 GRLQLQADRHQEHIRARDSLIQSLATRLELDGFERGPFSERQIKNFHTLVIERQEDEAKTAAQLCADLQSKERLKQEQAD 429
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   993 KLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKSKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQEsiMDLE 1072
Cdd:TIGR00606  430 EIRDEKKGLGRTIELKKEILEKKQEELKFVIKELQQLEGSSDRILELDQELRKAERELSKAEKNSLTETLKKEV--KSLQ 507
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1073 NDKQQSEEKLKKKDFETSQLLSKIEDEQSLGAQLQKK------IKELQARIEELEEEIEAERAARAKVEKQRADLSRELE 1146
Cdd:TIGR00606  508 NEKADLDRKLRKLDQEMEQLNHHTTTRTQMEMLTKDKmdkdeqIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEIN 587
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1147 EISERLEEAGGATAAQIEMNKKREAEFQKLRRdlEESTLQHEATAAALRKKQADSVAELGEQIDNLQRVKQKLEKEKSEY 1226
Cdd:TIGR00606  588 QTRDRLAKLNKELASLEQNKNHINNELESKEE--QLSSYEDKLFDVCGSQDEESDLERLKEEIEKSSKQRAMLAGATAVY 665
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1227 KMEIDDLSSNMEA-------VAKAKANLEKMCRTLEDQLSEIKSKNDENLRQINDLSAQRARLQTENGEFGRQLEEKEAL 1299
Cdd:TIGR00606  666 SQFITQLTDENQSccpvcqrVFQTEAELQEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKE 745
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1300 VSQLTRGKQAFTQQIEELKRQIEEEVKAKNALAHAVQSAR---HDCDLLREQFEEEQEAKAELQRGMSKANSeVAQWRTK 1376
Cdd:TIGR00606  746 IPELRNKLQKVNRDIQRLKNDIEEQETLLGTIMPEEESAKvclTDVTIMERFQMELKDVERKIAQQAAKLQG-SDLDRTV 824
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1377 YETDaiQRTEELEESKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQGEVEDLMIDVERANALAANLDKKQRNFDKVLA 1456
Cdd:TIGR00606  825 QQVN--QEKQEKQHELDTVVSKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQQFEEQLVELSTEVQSLIR 902
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1457 EWKQKYEEgQAELEGAQKEARSLSTELFKMKN-SYEETLDQLETLKRENKNLQQEISDLTEQLGEtGKsihelEKSKKAV 1535
Cdd:TIGR00606  903 EIKDAKEQ-DSPLETFLEKDQQEKEELISSKEtSNKKAQDKVNDIKEKVKNIHGYMKDIENKIQD-GK-----DDYLKQK 975
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1536 ETEKAEIQTALEEAEGTLE----------------HEESKILRVQLELNQVKSEI---DRKLAEKDEEIEQIKRNSQRIT 1596
Cdd:TIGR00606  976 ETELNTVNAQLEECEKHQEkinedmrlmrqdidtqKIQERWLQDNLTLRKRENELkevEEELKQHLKEMGQMQVLQMKQE 1055
                          730       740       750       760
                   ....*....|....*....|....*....|....*....|....*..
gi 288856329  1597 -DSMQSTLDSEVRSRNDALRIKKKMEGDLNEMEIQLSHANRQAAEAQ 1642
Cdd:TIGR00606 1056 hQKLEENIDLIKRNHVLALGRQKGYEKEIKHFKKELREPQFRDAEEK 1102
PTZ00121 PTZ00121
MAEBL; Provisional
1452-1935 1.22e-08

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 60.54  E-value: 1.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1452 DKVLAEWKQKYEEGQAELEGAQKEARSLSTELFKMKNSYE-ETLDQLETLKRENKNLQQEISDLTEQlgetGKSIHELEK 1530
Cdd:PTZ00121 1096 AFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEARKaEDARKAEEARKAEDAKRVEIARKAED----ARKAEEARK 1171
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1531 SKKAVETEKAEIQTALEEAEGTLEHEESKILRVQLELNQVKSEIDRKLAEKDEEIEQIKRNSQRITDSMQSTLDSEVRSR 1610
Cdd:PTZ00121 1172 AEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNN 1251
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1611 NDalrIKKKMEGDLNEMEIQLSHANRQAAEAQKQLRNVQAQLKDAQLHLDDAVRGQEDMKEQVamverrntlmqseiEEL 1690
Cdd:PTZ00121 1252 EE---IRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKA--------------EEA 1314
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1691 RAALE---QTERGRKVAEQELVDASERvgllhsqntsllntKKKLEADlvqiQSEVEDTVQEARNAEDKAK---KAITDA 1764
Cdd:PTZ00121 1315 KKADEakkKAEEAKKKADAAKKKAEEA--------------KKAAEAA----KAEAEAAADEAEAAEEKAEaaeKKKEEA 1376
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1765 AMMAEELKKEQDTSAHLERMKKNLEVTVKdlqhrldEAENLAMKGGKKQlqklesrvRELESEVEAEQRRGADAVKGVRK 1844
Cdd:PTZ00121 1377 KKKADAAKKKAEEKKKADEAKKKAEEDKK-------KADELKKAAAAKK--------KADEAKKKAEEKKKADEAKKKAE 1441
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1845 YERRVKELTYQTEEDKKNVNRLQDLVDKL---QLKVKA-YKRQSEEAE---EQANSHLSKLRKVQHELEEAEERADIAES 1917
Cdd:PTZ00121 1442 EAKKADEAKKKAEEAKKAEEAKKKAEEAKkadEAKKKAeEAKKADEAKkkaEEAKKKADEAKKAAEAKKKADEAKKAEEA 1521
                         490
                  ....*....|....*...
gi 288856329 1918 QVNKLRAKSRDSGKGKDA 1935
Cdd:PTZ00121 1522 KKADEAKKAEEAKKADEA 1539
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
1191-1548 1.29e-08

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 59.52  E-value: 1.29e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1191 AAALRKKQADSVAELGEQIDNLQRVKQKLEKEKSEYKMEIDDLSSNMEAVAKAKANLEKMCRTLEDQLSEIKSKNDENLR 1270
Cdd:pfam07888   29 AELLQNRLEECLQERAELLQAQEAANRQREKEKERYKRDREQWERQRRELESRVAELKEELRQSREKHEELEEKYKELSA 108
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1271 QINDLSAQRARLQTENGEFG---RQLEEKEALVSQLTRGKQA----FTQQIEELKRQIEEEVKAKNALAHAVQSARHDCD 1343
Cdd:pfam07888  109 SSEELSEEKDALLAQRAAHEariRELEEDIKTLTQRVLERETelerMKERAKKAGAQRKEEEAERKQLQAKLQQTEEELR 188
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1344 LLREQFEEEQEAKAELQRGMSKANSEVAQWRTKYETdAIQRTEELEESKKKLA---QRLQEAEEQIEAVNSKCASLEKTK 1420
Cdd:pfam07888  189 SLSKEFQELRNSLAQRDTQVLQLQDTITTLTQKLTT-AHRKEAENEALLEELRslqERLNASERKVEGLGEELSSMAAQR 267
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1421 QRLQGEVEDLMIDVERANALAANLDKKQRnfdKVLAEWKQKYEEGQAELEGAQKEARSLSTELFKMKNSYEETLDQLETL 1500
Cdd:pfam07888  268 DRTQAELHQARLQAAQLTLQLADASLALR---EGRARWAQERETLQQSAEADKDRIEKLSAELQRLEERLQEERMEREKL 344
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*...
gi 288856329  1501 KREnknLQQEISDLTEQLGETGKSIHELEKSKKAVETEKAEIQTALEE 1548
Cdd:pfam07888  345 EVE---LGREKDCNRVQLSESRRELQELKASLRVAQKEKEQLQAEKQE 389
PRK11281 PRK11281
mechanosensitive channel MscK;
1530-1790 1.58e-08

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 59.93  E-value: 1.58e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1530 KSKKAVETEKAEIQTALEEAEGTLEheesKILRVQLELNQVKseidRKLAEKDEEIEQIKRNSQRitdsMQSTLDSEVRS 1609
Cdd:PRK11281   49 NKQKLLEAEDKLVQQDLEQTLALLD----KIDRQKEETEQLK----QQLAQAPAKLRQAQAELEA----LKDDNDEETRE 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1610 RNDALRIKKkMEGDLNEMEIQLSHANRQAAEAQKQLRNVQAQLKDAQLHLDDAvrgqedmkeQVAMVERRNTLMQSEIEE 1689
Cdd:PRK11281  117 TLSTLSLRQ-LESRLAQTLDQLQNAQNDLAEYNSQLVSLQTQPERAQAALYAN---------SQRLQQIRNLLKGGKVGG 186
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1690 lrAALEQTERGRKVAEQELVDA--SERVGLL--HSQNTSLLNTK--------KKLEADLVQIQSEV--------EDTVQE 1749
Cdd:PRK11281  187 --KALRPSQRVLLQAEQALLNAqnDLQRKSLegNTQLQDLLQKQrdyltariQRLEHQLQLLQEAInskrltlsEKTVQE 264
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 288856329 1750 ARNAEDKAKkaITDAAMMAEELKKEQDTSAHL--------ERMKKNLEV 1790
Cdd:PRK11281  265 AQSQDEAAR--IQANPLVAQELEINLQLSQRLlkateklnTLTQQNLRV 311
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1617-1838 1.77e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 58.62  E-value: 1.77e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1617 KKKMEGDLNEMEIQLSHANRQAAEAQKQLRNVQAQLKDAQLHLDDAVRGQEDMKEQVAMVERRNTLMQSEIEELRAALEQ 1696
Cdd:COG4942    22 AAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEA 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1697 tergRKVAEQELVDASERVG-------LLHSQNTSLLNTKKKLEADLVQIQSEVEDTVQEARNAEDKAKKAITDAAMMAE 1769
Cdd:COG4942   102 ----QKEELAELLRALYRLGrqpplalLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELE 177
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1770 ELKKEQDTS-AHLERMKKNLEVTVKDLQHRLDEAENlAMKGGKKQLQKLESRVRELESEVEAEQRRGADA 1838
Cdd:COG4942   178 ALLAELEEErAALEALKAERQKLLARLEKELAELAA-ELAELQQEAEELEALIARLEAEAAAAAERTPAA 246
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1532-1928 1.97e-08

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 59.67  E-value: 1.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1532 KKAVETEKAEIQTALEEAEGTLEHEESKilrvqlELNQVKSEIDRKLAEKDEEIEQI---KRNSQRITDSMQSTLDsEVR 1608
Cdd:PRK02224  175 RLGVERVLSDQRGSLDQLKAQIEEKEEK------DLHERLNGLESELAELDEEIERYeeqREQARETRDEADEVLE-EHE 247
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1609 SRNDALrikKKMEGDLNEMEIQLSHANRQAAEAQKQLRNVQAQLKDAQLHLDDAVRGQE-DMKEQVAMVERRNTLmQSEI 1687
Cdd:PRK02224  248 ERREEL---ETLEAEIEDLRETIAETEREREELAEEVRDLRERLEELEEERDDLLAEAGlDDADAEAVEARREEL-EDRD 323
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1688 EELRAALEQTERGRKVAEQELVDASERVGLLHSQNTSLLNTKKKLEADLVQIQSEVED---TVQEARNAEDKAKKAITDA 1764
Cdd:PRK02224  324 EELRDRLEECRVAAQAHNEEAESLREDADDLEERAEELREEAAELESELEEAREAVEDrreEIEELEEEIEELRERFGDA 403
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1765 AM----MAEELKKEQDTSAHLERMKKNLEVTVKDLQHRLDEAENLaMKGGK----KQLQKLESRVRELEsevEAEQRRGa 1836
Cdd:PRK02224  404 PVdlgnAEDFLEELREERDELREREAELEATLRTARERVEEAEAL-LEAGKcpecGQPVEGSPHVETIE---EDRERVE- 478
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1837 davkgvrKYERRVKELTYQTEEDKKNVNRLQDLVdklqlkvkaykrqseEAEEQANSHLSKLRKVQHELEEAEERADIAE 1916
Cdd:PRK02224  479 -------ELEAELEDLEEEVEEVEERLERAEDLV---------------EAEDRIERLEERREDLEELIAERRETIEEKR 536
                         410
                  ....*....|..
gi 288856329 1917 SQVNKLRAKSRD 1928
Cdd:PRK02224  537 ERAEELRERAAE 548
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1239-1477 2.20e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 58.62  E-value: 2.20e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1239 AVAKAKANLEKMCRTLEDQLSEIKSKNDENLRQINDLSAQRARLQTENGEFGRQLEEKEALVSQLTRGKQAFTQQIEELK 1318
Cdd:COG4942    17 AQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELR 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1319 RQIEEEVKA-KNALAHAVQSARHDcdllREQFEEEQEAKAELQRgMSKANSEVAQWRtkyetdaIQRTEELEESKKKLAQ 1397
Cdd:COG4942    97 AELEAQKEElAELLRALYRLGRQP----PLALLLSPEDFLDAVR-RLQYLKYLAPAR-------REQAEELRADLAELAA 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1398 RLQEAEEQIEAVNSKCASLEKTKQRLQGEvedlmidVERANALAANLDKKQRNFDKVLAEWKQKYEEGQAELEGAQKEAR 1477
Cdd:COG4942   165 LRAELEAERAELEALLAELEEERAALEAL-------KAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAA 237
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
1039-1902 2.60e-08

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 59.29  E-value: 2.60e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1039 SLEQEKKLRMDLERAKRKLEGDLKL----------AQESIMDLENDKQQSEEKLKKKDFETSQLLSKiedeqslgaqlQK 1108
Cdd:TIGR00606  187 ALETLRQVRQTQGQKVQEHQMELKYlkqykekaceIRDQITSKEAQLESSREIVKSYENELDPLKNR-----------LK 255
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1109 KIKELQARIEELEeeieAERAARAKVEKQRADLSRELEEISERLEEAGGATAAQIEMNKKREA-EFQKLRRDLEESTLQH 1187
Cdd:TIGR00606  256 EIEHNLSKIMKLD----NEIKALKSRKKQMEKDNSELELKMEKVFQGTDEQLNDLYHNHQRTVrEKERELVDCQRELEKL 331
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1188 EATAAALRKKQADSVAELGE-----QIDNLQRVKQKLEKEKSEYKMEIDDLSSNME-------AVAKAKANLEKMCRTLE 1255
Cdd:TIGR00606  332 NKERRLLNQEKTELLVEQGRlqlqaDRHQEHIRARDSLIQSLATRLELDGFERGPFserqiknFHTLVIERQEDEAKTAA 411
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1256 DQLSEIKSKNDENLRQINDLSAQRARLQTENGEFGRQLEEKEALVSQLTRGKQAFTQQIEELKRQIEEEVKAKNALAHAV 1335
Cdd:TIGR00606  412 QLCADLQSKERLKQEQADEIRDEKKGLGRTIELKKEILEKKQEELKFVIKELQQLEGSSDRILELDQELRKAERELSKAE 491
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1336 QSARHDCDLLREQFeeEQEAKAELQRGMSKANSEVAQwrTKYETDAIQRTEELEESKKKLAQRLQEAEEQIEAVNSKCAS 1415
Cdd:TIGR00606  492 KNSLTETLKKEVKS--LQNEKADLDRKLRKLDQEMEQ--LNHHTTTRTQMEMLTKDKMDKDEQIRKIKSRHSDELTSLLG 567
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1416 LEKTKQRLQGEVEDLMIDVERanalaanLDKKQRNFDKVLAEWKQKYEEGQAELEGAQKEARSLSTELFKMKNSYEETLD 1495
Cdd:TIGR00606  568 YFPNKKQLEDWLHSKSKEINQ-------TRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDKLFDVCGSQDEESD 640
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1496 qLETLKRENKNLQQEISDLTEQLGETGKSIHEL-EKSKKAVETEKAEIQTALEEAEgTLEHEESKILRVQLELNQVKSEI 1574
Cdd:TIGR00606  641 -LERLKEEIEKSSKQRAMLAGATAVYSQFITQLtDENQSCCPVCQRVFQTEAELQE-FISDLQSKLRLAPDKLKSTESEL 718
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1575 DRKLAEKDEEIEQIKrNSQRITDSMQSTLdSEVRSRNDAL-RIKKKMEGDLNEMEIQLSHANRQAAEAQKQLRNV----- 1648
Cdd:TIGR00606  719 KKKEKRRDEMLGLAP-GRQSIIDLKEKEI-PELRNKLQKVnRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVtimer 796
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1649 -QAQLKDAQLHLDDAVrGQEDMKEQVAMVERRNTLMQSEIEELRAALEQTERGRKVAEqelvDASERVGLLHSQNTSLLN 1727
Cdd:TIGR00606  797 fQMELKDVERKIAQQA-AKLQGSDLDRTVQQVNQEKQEKQHELDTVVSKIELNRKLIQ----DQQEQIQHLKSKTNELKS 871
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1728 TKKKLEADLVQIQSEVEDTVQEA-------RNAEDKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEVTVKDLQHRLD 1800
Cdd:TIGR00606  872 EKLQIGTNLQRRQQFEEQLVELStevqsliREIKDAKEQDSPLETFLEKDQQEKEELISSKETSNKKAQDKVNDIKEKVK 951
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1801 EA-------ENLAMKGGKKQLQKLESRVRELESEVEAEQRRGadavkgvRKYERRVKELTYQTEEDKKNVNRLQDlvdkl 1873
Cdd:TIGR00606  952 NIhgymkdiENKIQDGKDDYLKQKETELNTVNAQLEECEKHQ-------EKINEDMRLMRQDIDTQKIQERWLQD----- 1019
                          890       900
                   ....*....|....*....|....*....
gi 288856329  1874 QLKVKAYKRQSEEAEEQANSHLSKLRKVQ 1902
Cdd:TIGR00606 1020 NLTLRKRENELKEVEEELKQHLKEMGQMQ 1048
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1495-1712 3.02e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 57.85  E-value: 3.02e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1495 DQLETLKRENKNLQQEISDLTEQLGETGKSIHELEKSKKAVETEKAEIQTALEEAEGTLEHEESKILRVQLELNQVKSEI 1574
Cdd:COG4942    20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1575 DRKLAEKDEEIEQIKRNSQRITDSM----QSTLDSEVRSR--NDALRIKKKMEGDLNEMEIQLSHANRQAAEAQKQLRNV 1648
Cdd:COG4942   100 EAQKEELAELLRALYRLGRQPPLALllspEDFLDAVRRLQylKYLAPARREQAEELRADLAELAALRAELEAERAELEAL 179
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 288856329 1649 QAQLKDAQLHLDDAVRGQEDM----KEQVAMVERRNTLMQSEIEELRAALEQTERGRKVAEQELVDAS 1712
Cdd:COG4942   180 LAELEEERAALEALKAERQKLlarlEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAAG 247
MARTX_Nterm NF012221
MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model ...
1355-1649 3.62e-08

MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model describes the N-terminal 1900 amino acids of MARTX family multifunctional-autoprocessing repeats-in-toxin holotoxins, which contain both repeat regions that facilitate their entry into eukaryotic target cells, and multiple effector domains.


Pssm-ID: 467957 [Multi-domain]  Cd Length: 1848  Bit Score: 59.08  E-value: 3.62e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1355 AKAELQRGMSKANSEVAQwrTKYETDAIQRTEELEESKKKLAQrlqEAEEQIEAVNSKCASLEKTKQrlqgevedlmidv 1434
Cdd:NF012221 1536 ATSESSQQADAVSKHAKQ--DDAAQNALADKERAEADRQRLEQ---EKQQQLAAISGSQSQLESTDQ------------- 1597
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1435 eraNALAANldkkqrnfdkvlaewkqkyeeGQAELEGAQKEARSLSTELFKMKnsyeETLDQLETLKRENKNLQQE---- 1510
Cdd:NF012221 1598 ---NALETN---------------------GQAQRDAILEESRAVTKELTTLA----QGLDALDSQATYAGESGDQwrnp 1649
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1511 -----ISDLTEQLGETGKSIHE-LEKSKKAVETEKAEIQTALEEAEGTLEHEESKILRVQLELNQVKSEIDRKlaeKDEE 1584
Cdd:NF012221 1650 fagglLDRVQEQLDDAKKISGKqLADAKQRHVDNQQKVKDAVAKSEAGVAQGEQNQANAEQDIDDAKADAEKR---KDDA 1726
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 288856329 1585 IEQIKRNSQRITDSMQSTLDSEVRSRNDAlrikkkmegdlnemeiqlSHANRQAAEAQKQLRNVQ 1649
Cdd:NF012221 1727 LAKQNEAQQAESDANAAANDAQSRGEQDA------------------SAAENKANQAQADAKGAK 1773
PRK01156 PRK01156
chromosome segregation protein; Provisional
1019-1597 3.64e-08

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 58.76  E-value: 3.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1019 VNTLTKSKTKLEQQVDDLEGSLEQEKKLRMDLERakrklegdlklaqeSIMDLENDKQQSEEKLKKKdfetSQLLSKIED 1098
Cdd:PRK01156  161 INSLERNYDKLKDVIDMLRAEISNIDYLEEKLKS--------------SNLELENIKKQIADDEKSH----SITLKEIER 222
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1099 EQSLGAQLQKKIKELQARIEELEEEIEAERAARAKVEKQRADLSRELEE---ISERLEEAGGATAAQIEMNKKREAEFQK 1175
Cdd:PRK01156  223 LSIEYNNAMDDYNNLKSALNELSSLEDMKNRYESEIKTAESDLSMELEKnnyYKELEERHMKIINDPVYKNRNYINDYFK 302
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1176 LRRDLEESTLQHEATAAALRKKQADSVAELGEQIDNLQRVKQKleKEKSEYKMEIDDLSSNMEAVAKAKANLEKMCRTLE 1255
Cdd:PRK01156  303 YKNDIENKKQILSNIDAEINKYHAIIKKLSVLQKDYNDYIKKK--SRYDDLNNQILELEGYEMDYNSYLKSIESLKKKIE 380
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1256 DQLSEIKSKNDENLRQINDLSAQRARLQTENGEFGRQLEEKEALVSQLTRGKQAFTQQIEELKRQIEEEVKAKNALAHAV 1335
Cdd:PRK01156  381 EYSKNIERMSAFISEILKIQEIDPDAIKKELNEINVKLQDISSKVSSLNQRIRALRENLDELSRNMEMLNGQSVCPVCGT 460
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1336 QSARHDCDLLREQFEEE----QEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEESKKKLAQ-------------R 1398
Cdd:PRK01156  461 TLGEEKSNHIINHYNEKksrlEEKIREIEIEVKDIDEKIVDLKKRKEYLESEEINKSINEYNKIESaradledikikinE 540
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1399 LQEAEEQIEAVNSKCASLEktkqrlQGEVEDLMIDVERANALAANLD-----KKQRNFDKVLAEWKQKYEEGQAELEGAQ 1473
Cdd:PRK01156  541 LKDKHDKYEEIKNRYKSLK------LEDLDSKRTSWLNALAVISLIDietnrSRSNEIKKQLNDLESRLQEIEIGFPDDK 614
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1474 KEARSLSTELFKMKNSYEETLDQLETLKRENKNLQQEISDLTEQLGEtgksIHELEKSKKAVETEKAEIQTALEEAEGTL 1553
Cdd:PRK01156  615 SYIDKSIREIENEANNLNNKYNEIQENKILIEKLRGKIDNYKKQIAE----IDSIIPDLKEITSRINDIEDNLKKSRKAL 690
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*..
gi 288856329 1554 EHEESKI--LRVQLELNQVK-SEIDRKLAEKDEEIEQIKRNSQRITD 1597
Cdd:PRK01156  691 DDAKANRarLESTIEILRTRiNELSDRINDINETLESMKKIKKAIGD 737
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
882-1147 3.81e-08

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 58.58  E-value: 3.81e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   882 LLQEKNDLQLAVASESENLSDAEERCEGLIKskiQLEaKLKETTERLEDE-EEINAELTAKKRKLEDECSELKKDIDDLE 960
Cdd:pfam05483  504 LTQEASDMTLELKKHQEDIINCKKQEERMLK---QIE-NLEEKEMNLRDElESVREEFIQKGDEVKCKLDKSEENARSIE 579
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   961 LTLAKVEKEKHATENKVKNLTEEMAAQDESIGKLTKEKKALQEAHQQTLDDLQAEEDKVNT----LTKSKTKLEQQVDDL 1036
Cdd:pfam05483  580 YEVLKKEKQMKILENKCNNLKKQIENKNKNIEELHQENKALKKKGSAENKQLNAYEIKVNKleleLASAKQKFEEIIDNY 659
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1037 EGSLE----QEKKLRMDLERAKRKLEGDLKLAQ-----------ESIMDLENDKQQSEEKLKKKDFETSQLLSKIEDEQS 1101
Cdd:pfam05483  660 QKEIEdkkiSEEKLLEEVEKAKAIADEAVKLQKeidkrcqhkiaEMVALMEKHKHQYDKIIEERDSELGLYKNKEQEQSS 739
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 288856329  1102 LGAQLQKKIKELQARIEELEEEIEAERAARAKVEKQRADLSRELEE 1147
Cdd:pfam05483  740 AKAALEIELSNIKAELLSLKKQLEIEKEEKEKLKMEAKENTAILKD 785
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
1452-1603 5.35e-08

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 55.70  E-value: 5.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1452 DKVLAEWKQKYEEGQAELEGAQKEARSLSTELFKMKNSYEETLDQLETLKRENKNLQQEISDLTEQLGETGKS------- 1524
Cdd:COG1579    16 DSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVRNNkeyealq 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1525 --IHELEKSKKAVETEKAEIQTALEEAEGTLEHEESKILRVQLELNQVKSEIDRKLAEKDEEIEQIKRNSQRITDSMQST 1602
Cdd:COG1579    96 keIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREELAAKIPPE 175

                  .
gi 288856329 1603 L 1603
Cdd:COG1579   176 L 176
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1012-1333 8.19e-08

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 57.62  E-value: 8.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1012 LQAEEDKVNTLTKSKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKL--AQESIMDLENDKQQseeklkkkdfet 1089
Cdd:COG4913   612 LAALEAELAELEEELAEAEERLEALEAELDALQERREALQRLAEYSWDEIDVasAEREIAELEAELER------------ 679
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1090 sqllskIEDEQSLGAQLQKKIKELQARIEELEEEIEAERAARAKVEKQRADLSRELEEISERLEEAGGATAAQiemnkkR 1169
Cdd:COG4913   680 ------LDASSDDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLE------L 747
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1170 EAEFQKLRRDLEEstlqhEATAAALRKKQADSVAELGEQIDNL-QRVKQKLEKEKSEYKMEIDDLSSNMEAVAKakanLE 1248
Cdd:COG4913   748 RALLEERFAAALG-----DAVERELRENLEERIDALRARLNRAeEELERAMRAFNREWPAETADLDADLESLPE----YL 818
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1249 KMCRTLEDqlseikskndenlrqiNDLSAQRARLqtengefgrqleeKEALVSQLTRGKQAFTQQIEELKRQIEEEVKAK 1328
Cdd:COG4913   819 ALLDRLEE----------------DGLPEYEERF-------------KELLNENSIEFVADLLSKLRRAIREIKERIDPL 869

                  ....*.
gi 288856329 1329 N-ALAH 1333
Cdd:COG4913   870 NdSLKR 875
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
1479-1906 1.10e-07

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 56.95  E-value: 1.10e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1479 LSTELFKMKNSYEETLDQLETLKRENKNLQQEISDLTEQLGETGKSIHELEKSKKAVETEKAEIQTALEEAEGTLEHEE- 1557
Cdd:TIGR04523  122 LEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNIDKIKNKLLKLEl 201
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1558 ----------------SKILRVQLELNQVKSEIDRKLAEKDEEIEQIKRNSQRITDSMQS------TLDSEVRSRNDALR 1615
Cdd:TIGR04523  202 llsnlkkkiqknksleSQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEqnkikkQLSEKQKELEQNNK 281
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1616 IKKKMEGDLNEMEIQLSHANRQAA-----EAQKQLRNVQAQLKDAQLHLDDAVRGQEDMKEQVAMVERRNTLMQSEIEEL 1690
Cdd:TIGR04523  282 KIKELEKQLNQLKSEISDLNNQKEqdwnkELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNSESENSEK 361
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1691 RAALEQTERgrkvaeqelvdaseRVGLLHSQNTSLLNTKKKLEADLVQIQSEVEDTVQEARNAEDKAKKAITDAAMMAEE 1770
Cdd:TIGR04523  362 QRELEEKQN--------------EIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKE 427
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1771 LKKEQDTSAHLERMKKNLEVTVKDLQHRLDEAENLaMKGGKKQLQKLESRVRELESEVEAEQRRGADAVKGVRKYERRVK 1850
Cdd:TIGR04523  428 IERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNT-RESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKK 506
                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 288856329  1851 ELTYQTEEDKKNVNRLQDLVDKLQLKVKAYKRQSEEAEEQANSHLSKLRKVQHELE 1906
Cdd:TIGR04523  507 ELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEDELNKDDFELKKENLEKE 562
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
1172-1697 1.29e-07

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 56.75  E-value: 1.29e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1172 EFQKLRRDLEESTLQHEATAAALRKKQaDSVAELGEQIDNlQRVKQKLEKEKSEYKMEIDDLSSnmeAVAKAKANLEKMC 1251
Cdd:pfam10174  131 ELFLLRKTLEEMELRIETQKQTLGARD-ESIKKLLEMLQS-KGLPKKSGEEDWERTRRIAEAEM---QLGHLEVLLDQKE 205
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1252 RTLEDQLSEIKSKNdenlrQINDLSAQRARLQTengefgrQLEEKEALVSQLTRGKQAFTQQIEELKRQIEEEVKAKNAL 1331
Cdd:pfam10174  206 KENIHLREELHRRN-----QLQPDPAKTKALQT-------VIEMKDTKISSLERNIRDLEDEVQMLKTNGLLHTEDREEE 273
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1332 AHAVQSARHDCDLLREQFEEeqeakaeLQRGMSKANSEVAQWRTKYET------DAIQRTEELEESKKKLAQR------- 1398
Cdd:pfam10174  274 IKQMEVYKSHSKFMKNKIDQ-------LKQELSKKESELLALQTKLETltnqnsDCKQHIEVLKESLTAKEQRaailqte 346
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1399 -------LQEAEEQIEAVNSKCASLEKTKQRLQGEVEDL--MIDVE--RANALAA---NLDKKQRNFDKVLAEWKQKYEE 1464
Cdd:pfam10174  347 vdalrlrLEEKESFLNKKTKQLQDLTEEKSTLAGEIRDLkdMLDVKerKINVLQKkieNLQEQLRDKDKQLAGLKERVKS 426
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1465 GQ----------AELEGAQKEARSLSTELFKMKNSYE-ETLDQLETLKRENKNLQQEISDLTEQLGETGKSIHELEKSKK 1533
Cdd:pfam10174  427 LQtdssntdtalTTLEEALSEKERIIERLKEQREREDrERLEELESLKKENKDLKEKVSALQPELTEKESSLIDLKEHAS 506
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1534 AVETEKAEIQTALEEAEGTLEH--EESKILRVQLELNQVKSEIDRKLAEKDEEIEQIKRNSQRITDSmQSTLDSEVRSRN 1611
Cdd:pfam10174  507 SLASSGLKKDSKLKSLEIAVEQkkEECSKLENQLKKAHNAEEAVRTNPEINDRIRLLEQEVARYKEE-SGKAQAEVERLL 585
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1612 DALRI----KKKMEGDLNEMEiqlSHANRQAAEAQKQLRNVQA-----QLKDAQLhLDDAVRGQEDMKEQVAmverrntl 1682
Cdd:pfam10174  586 GILREveneKNDKDKKIAELE---SLTLRQMKEQNKKVANIKHgqqemKKKGAQL-LEEARRREDNLADNSQ-------- 653
                          570
                   ....*....|....*
gi 288856329  1683 mQSEIEELRAALEQT 1697
Cdd:pfam10174  654 -QLQLEELMGALEKT 667
PRK10246 PRK10246
exonuclease subunit SbcC; Provisional
1243-1869 1.46e-07

exonuclease subunit SbcC; Provisional


Pssm-ID: 182330 [Multi-domain]  Cd Length: 1047  Bit Score: 56.73  E-value: 1.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1243 AKANLEKmcrtLEDQLSEIKSKNDENLRQIND----LSAQRARLQTENGEFGRQLE---EKEALVSQLTRGKQAFTQQIE 1315
Cdd:PRK10246  196 ARTELEK----LQAQASGVALLTPEQVQSLTAslqvLTDEEKQLLTAQQQQQQSLNwltRLDELQQEASRRQQALQQALA 271
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1316 ELKrqieeevKAKNALA--HAVQSARHdcdlLREQFEEEQEAKAELQRGMSKANS------EVAQWRTKYETDAIQRTEE 1387
Cdd:PRK10246  272 AEE-------KAQPQLAalSLAQPARQ----LRPHWERIQEQSAALAHTRQQIEEvntrlqSTMALRARIRHHAAKQSAE 340
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1388 LEESKKKLAQRLQEAE------EQIEAVNSKCASLEKTKQRLQGEVEDLMIDVERANALAAN-LDKKQRNFDKVLAEwkq 1460
Cdd:PRK10246  341 LQAQQQSLNTWLAEHDrfrqwnNELAGWRAQFSQQTSDREQLRQWQQQLTHAEQKLNALPAItLTLTADEVAAALAQ--- 417
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1461 kyeegqaelegaQKEARSLSTELFKMKNSYEETLDQLETLKRENKNLQQEISDLTEQLGET-------------GKSIHE 1527
Cdd:PRK10246  418 ------------HAEQRPLRQRLVALHGQIVPQQKRLAQLQVAIQNVTQEQTQRNAALNEMrqrykektqqladVKTICE 485
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1528 LEKSKKAVETEKAEIQTALE------------EAEGTLEHEESKILRVQLE--LNQVKSEIDRKLAEKDEEIEQIKRN-- 1591
Cdd:PRK10246  486 QEARIKDLEAQRAQLQAGQPcplcgstshpavEAYQALEPGVNQSRLDALEkeVKKLGEEGAALRGQLDALTKQLQRDes 565
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1592 -SQRITDSMQsTLDSEVRSRNDALRIKKKMEGDLN-------EMEIQLSHANR------QAAEAQKQLRNVQAQLKDAQL 1657
Cdd:PRK10246  566 eAQSLRQEEQ-ALTQQWQAVCASLNITLQPQDDIQpwldaqeEHERQLRLLSQrhelqgQIAAHNQQIIQYQQQIEQRQQ 644
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1658 HLDDAVRG-----QEDMKEQVAMVER------------RNTLMQSEIEELRAALEQTERGRKVAEQELVDASERVGLLHS 1720
Cdd:PRK10246  645 QLLTALAGyaltlPQEDEEASWLATRqqeaqswqqrqnELTALQNRIQQLTPLLETLPQSDDLPHSEETVALDNWRQVHE 724
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1721 QNTSLLNTKKKLEADLVQIQSEVEDtVQEARNAEDKAKKAITDAAMMAEELKKEqdTSAHLERMKKNLEvtvkdlqHRLD 1800
Cdd:PRK10246  725 QCLSLHSQLQTLQQQDVLEAQRLQK-AQAQFDTALQASVFDDQQAFLAALLDEE--TLTQLEQLKQNLE-------NQRQ 794
                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 288856329 1801 EAENLAMKGGKKQLQKLESRVRELESEVEAEQRRGADAV--KGVRKYERRVKELTYQTEEDKKNVNRLQDL 1869
Cdd:PRK10246  795 QAQTLVTQTAQALAQHQQHRPDGLDLTVTVEQIQQELAQlaQQLRENTTRQGEIRQQLKQDADNRQQQQAL 865
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
1305-1900 1.48e-07

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 56.68  E-value: 1.48e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1305 RGKQAFTQQIEELKRQIEEEVKAKNALAHAVQSARHDCDLLREQFEE-------EQEAKAELQrGMSKANSEVAQWRTKY 1377
Cdd:pfam07111   56 EGSQALSQQAELISRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMEldalavaEKAGQAEAE-GLRAALAGAEMVRKNL 134
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1378 ETDAIQRTEELEE-SKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQ----GEVEDLMIDVERANALAANLDKKQRNFD 1452
Cdd:pfam07111  135 EEGSQRELEEIQRlHQEQLSSLTQAHEEALSSLTSKAEGLEKSLNSLEtkraGEAKQLAEAQKEAELLRKQLSKTQEELE 214
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1453 K--VLAEWKQKYEEGQaelegAQKEARSLSTELFKmknsyEETLDQLETLKRENKNLQQEISDLTEQLGETGK--SIHEL 1528
Cdd:pfam07111  215 AqvTLVESLRKYVGEQ-----VPPEVHSQTWELER-----QELLDTMQHLQEDRADLQATVELLQVRVQSLTHmlALQEE 284
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1529 EKSKKAVETEKAEIQTAlEEAEGTLEHEESKI--LRVQLELNQVK-SEIDRKLAEKDEEI-EQIKRNSQRITDSMQSTLD 1604
Cdd:pfam07111  285 ELTRKIQPSDSLEPEFP-KKCRSLLNRWREKVfaLMVQLKAQDLEhRDSVKQLRGQVAELqEQVTSQSQEQAILQRALQD 363
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1605 SEVRSRNDALRIkKKMEGDLNEMEIQLSHANRQAAEAQKQLRNVQAQLKDAQLHLDDAVRGQEDMKEQVAMVERRNTLMQ 1684
Cdd:pfam07111  364 KAAEVEVERMSA-KGLQMELSRAQEARRRQQQQTASAEEQLKFVVNAMSSTQIWLETTMTRVEQAVARIPSLSNRLSYAV 442
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1685 SEIEELRAALeqterGRKVAEQEL-------------VDASERVGLLHsqntsLLNTKKKLEADLVQIQSEVEDTVQEAR 1751
Cdd:pfam07111  443 RKVHTIKGLM-----ARKVALAQLrqescpppppappVDADLSLELEQ-----LREERNRLDAELQLSAHLIQQEVGRAR 512
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1752 NAEDKAKKAITDAAMMAE-ELKKEQDTsahLERMKKNLEVTVKDLQHRLDEAENLAMKGGKKQ----------LQKLESR 1820
Cdd:pfam07111  513 EQGEAERQQLSEVAQQLEqELQRAQES---LASVGQQLEVARQGQQESTEEAASLRQELTQQQeiygqalqekVAEVETR 589
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1821 VRELESEVEAE----QRRGADAVKGVRKYERRVKeltyQTEEDKKNVNRLQDLVDKLQLKVKAykRQSEEAEEQANSHLS 1896
Cdd:pfam07111  590 LREQLSDTKRRlneaRREQAKAVVSLRQIQHRAT----QEKERNQELRRLQDEARKEEGQRLA--RRVQELERDKNLMLA 663

                   ....
gi 288856329  1897 KLRK 1900
Cdd:pfam07111  664 TLQQ 667
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
971-1201 1.51e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 55.93  E-value: 1.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  971 HATENKVKNLTEEMAAQDESIGKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKSKTKLEQQVDDLEGSL----EQEKKL 1046
Cdd:COG4942    16 AAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELaeleKEIAEL 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1047 RMDLERAKRKLEGDLKLAQESimdlendKQQSEEK--LKKKDFETS----QLLSKIEDE-QSLGAQLQKKIKELQARIEE 1119
Cdd:COG4942    96 RAELEAQKEELAELLRALYRL-------GRQPPLAllLSPEDFLDAvrrlQYLKYLAPArREQAEELRADLAELAALRAE 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1120 LEEEIEAERAARAKVEKQRADLSRELEEISERLEEAggatAAQIEMNKKREAEFQKLRRDLEESTLQHEATAAALRKKQA 1199
Cdd:COG4942   169 LEAERAELEALLAELEEERAALEALKAERQKLLARL----EKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTP 244

                  ..
gi 288856329 1200 DS 1201
Cdd:COG4942   245 AA 246
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1453-1657 1.67e-07

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 56.56  E-value: 1.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1453 KVLAEWKQKYEEGQAEL--EGAQKEARSLSTELFKMKNSYEETLDQLETLKRENK--NLQQEISDLTEQLGETGKSIHEL 1528
Cdd:COG3206   152 AVANALAEAYLEQNLELrrEEARKALEFLEEQLPELRKELEEAEAALEEFRQKNGlvDLSEEAKLLLQQLSELESQLAEA 231
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1529 EKSKKAVETEKAEIQTALEEAEGTLE--HEESKILRVQLELNQVKSEIDRKLA----------EKDEEIEQIKRNSQRIT 1596
Cdd:COG3206   232 RAELAEAEARLAALRAQLGSGPDALPelLQSPVIQQLRAQLAELEAELAELSArytpnhpdviALRAQIAALRAQLQQEA 311
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 288856329 1597 DSMQSTLDSEV---RSRNDALR-----IKKKMEgDLNEMEIQLSHANRQAAEAQKQLRNVQAQLKDAQL 1657
Cdd:COG3206   312 QRILASLEAELealQAREASLQaqlaqLEARLA-ELPELEAELRRLEREVEVARELYESLLQRLEEARL 379
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
977-1447 1.73e-07

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 56.31  E-value: 1.73e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  977 VKNLTEEMAAQDESIGKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKSKTKLEQQVDDLEGSLEQEKKLRMDLERAKRK 1056
Cdd:COG4717    48 LERLEKEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQL 127
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1057 LEgdlklaqesimdLENDKQQSEEKLKKKDFETSQLLSKIEDEQSLGAQLQKKIKELQARIEELEEEIEAERAArakVEK 1136
Cdd:COG4717   128 LP------------LYQELEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLA---TEE 192
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1137 QRADLSRELEEISERLEEAGGATaaqiemnKKREAEFQKLRRDLEESTLQHEATAAALRKKQADSVAELGEQIDNLQRVK 1216
Cdd:COG4717   193 ELQDLAEELEELQQRLAELEEEL-------EEAQEELEELEEELEQLENELEAAALEERLKEARLLLLIAAALLALLGLG 265
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1217 QKLEKEKSEYKMEIDDLSSNMEAVAKAKANLEKMCRTLEDQLSEIKSKNDENLRQINDLSAQRARLQTENGEFGRQLEEK 1296
Cdd:COG4717   266 GSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDR 345
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1297 EALVSQLTRGKQAFTQQIEELKRQIEEEVKAKNALAHAVQSARHDCDLLREqFEEEQEAKAELQRGMSKANSEVAQWRTK 1376
Cdd:COG4717   346 IEELQELLREAEELEEELQLEELEQEIAALLAEAGVEDEEELRAALEQAEE-YQELKEELEELEEQLEELLGELEELLEA 424
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 288856329 1377 YETDAI-QRTEELEESKKKLAQRLQEAEEQIEAVNSKCASLEKtkqrlQGEVEDLMIDVERANALAANLDKK 1447
Cdd:COG4717   425 LDEEELeEELEELEEELEELEEELEELREELAELEAELEQLEE-----DGELAELLQELEELKAELRELAEE 491
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
912-1270 1.85e-07

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 56.30  E-value: 1.85e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   912 KSKIQLEAKLKETTERLEDEEEINAELTAKKRKLEDECSELKKDIDD-LELTLAKVE-----------KEKHATENKVKN 979
Cdd:pfam09731   86 KKQVKIPRQSGVSSEVAEEEKEATKDAAEAKAQLPKSEQEKEKALEEvLKEAISKAEsatavakeakdDAIQAVKAHTDS 165
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   980 LTEEMAAQDESIGKLTKEKKALQEAHQQTLDDLQAEEDKVNTlTKSKTKLEQQVDDLEGSLEQEKKLRMDLERAkRKLEG 1059
Cdd:pfam09731  166 LKEASDTAEISREKATDSALQKAEALAEKLKEVINLAKQSEE-EAAPPLLDAAPETPPKLPEHLDNVEEKVEKA-QSLAK 243
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1060 DLKLAQESIMDLENDKQQSEEKL---------KKKDFETSQLLSKIEDEQSLGAQLQKKIKELQARIEELEEEieaeraa 1130
Cdd:pfam09731  244 LVDQYKELVASERIVFQQELVSIfpdiipvlkEDNLLSNDDLNSLIAHAHREIDQLSKKLAELKKREEKHIER------- 316
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1131 raKVEKQRADLSRELEEISERLEEAGGATAAQIEmnKKREAEFQKLRRDLEES---TLQHEATAAALRKKQADSVAELGE 1207
Cdd:pfam09731  317 --ALEKQKEELDKLAEELSARLEEVRAADEAQLR--LEFEREREEIRESYEEKlrtELERQAEAHEEHLKDVLVEQEIEL 392
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 288856329  1208 QIDNLQRVKQKLEKEKSEYKmeiddlssnmEAVAKAKANLekmcRTLEDQLSEIKSKNDENLR 1270
Cdd:pfam09731  393 QREFLQDIKEKVEEERAGRL----------LKLNELLANL----KGLEKATSSHSEVEDENRK 441
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
1486-1922 1.91e-07

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 56.00  E-value: 1.91e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1486 MKNSYEETLDQLETLKRE--NKNLQQEISDLtEQLGETGKSIHELEKSKKA----VETEKAEIQTALEEAEGTLE----- 1554
Cdd:PRK04778   23 LRKRNYKRIDELEERKQEleNLPVNDELEKV-KKLNLTGQSEEKFEEWRQKwdeiVTNSLPDIEEQLFEAEELNDkfrfr 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1555 HEESKILRVQLELNQVKSEIDRKLAEKDEEIEQIKRNSQRIT------DSMQSTLDSEVRSRNDALrikKKMEGDLNEME 1628
Cdd:PRK04778  102 KAKHEINEIESLLDLIEEDIEQILEELQELLESEEKNREEVEqlkdlyRELRKSLLANRFSFGPAL---DELEKQLENLE 178
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1629 IQLSHANRQAA-----EAQKQLRNVQAQLkdAQLhlddavrgQEDMKEQVAMVERRNTLMQSEIEELRAALEQ-TERGRK 1702
Cdd:PRK04778  179 EEFSQFVELTEsgdyvEAREILDQLEEEL--AAL--------EQIMEEIPELLKELQTELPDQLQELKAGYRElVEEGYH 248
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1703 VAEQELVdasERVGLLHSQNTSLLNTKKKLEAD-----LVQIQSEVE---DTVQ---EARNAEDKAKKAITDAAMMAEEL 1771
Cdd:PRK04778  249 LDHLDIE---KEIQDLKEQIDENLALLEELDLDeaeekNEEIQERIDqlyDILErevKARKYVEKNSDTLPDFLEHAKEQ 325
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1772 KKEqdTSAHLERMKKNLEVT------VKDLQHRLDEAENL------AMKGGKKQLQKLESRVRELE---SEVEAEQRRGA 1836
Cdd:PRK04778  326 NKE--LKEEIDRVKQSYTLNeselesVRQLEKQLESLEKQydeiteRIAEQEIAYSELQEELEEILkqlEEIEKEQEKLS 403
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1837 DAVKGVRKYERRVKELTYQTEEDKKNVNRlqdLVDKLQL-----KVKAYKRQSEEAEEQANSHLSKLR----KVQHELEE 1907
Cdd:PRK04778  404 EMLQGLRKDELEAREKLERYRNKLHEIKR---YLEKSNLpglpeDYLEMFFEVSDEIEALAEELEEKPinmeAVNRLLEE 480
                         490
                  ....*....|....*
gi 288856329 1908 AEERADIAESQVNKL 1922
Cdd:PRK04778  481 ATEDVETLEEETEEL 495
PRK01156 PRK01156
chromosome segregation protein; Provisional
1427-1925 2.39e-07

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 56.06  E-value: 2.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1427 VEDLMIDVERANALAANLDKKQRNFDKVLAEWKQKYEEGQAELEGAQKEARSLSTELFKM------KNSYEETLDQLETL 1500
Cdd:PRK01156  185 IDYLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNNLKSALNELssledmKNRYESEIKTAESD 264
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1501 KRENKNLQQEISDLTEQLGETGKS---------------IHELEKSKKAVETEKAEIQT--ALEEAEGTLEHEESKILRV 1563
Cdd:PRK01156  265 LSMELEKNNYYKELEERHMKIINDpvyknrnyindyfkyKNDIENKKQILSNIDAEINKyhAIIKKLSVLQKDYNDYIKK 344
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1564 QLELNQVKSEIDrklaekdeEIEQIKRNSQRITDSMQSTLDSEVRSRNDALRIKKKMEGDLNEMEIQLSHANRQAAEAQK 1643
Cdd:PRK01156  345 KSRYDDLNNQIL--------ELEGYEMDYNSYLKSIESLKKKIEEYSKNIERMSAFISEILKIQEIDPDAIKKELNEINV 416
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1644 QLRNVQAQLKDAQLHLDDAVRGQEDMKEQVAMVERRN-------TLMQSEIEELR-----------AALEQTERGRKVAE 1705
Cdd:PRK01156  417 KLQDISSKVSSLNQRIRALRENLDELSRNMEMLNGQSvcpvcgtTLGEEKSNHIInhynekksrleEKIREIEIEVKDID 496
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1706 QELVDASERVGLLHSQNTSLLNTKKKLEADLVQIQSEVEDTVQEARNAEDKAKKAITDAAMMAEELKKEQDTSaHLERMK 1785
Cdd:PRK01156  497 EKIVDLKKRKEYLESEEINKSINEYNKIESARADLEDIKIKINELKDKHDKYEEIKNRYKSLKLEDLDSKRTS-WLNALA 575
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1786 KNLEVTVKDLQHRLDEAenlamkggKKQLQKLESRVRELESEVEaeqrrgaDAVKGVRKYERRVKELTYQTEEDKKNVNR 1865
Cdd:PRK01156  576 VISLIDIETNRSRSNEI--------KKQLNDLESRLQEIEIGFP-------DDKSYIDKSIREIENEANNLNNKYNEIQE 640
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 288856329 1866 LQDLVDKLQLKVKAYKRQS---EEAEEQANSHLSKLRKVQHELEEAEERADIAESQVNKLRAK 1925
Cdd:PRK01156  641 NKILIEKLRGKIDNYKKQIaeiDSIIPDLKEITSRINDIEDNLKKSRKALDDAKANRARLEST 703
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
836-1264 2.79e-07

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 55.84  E-value: 2.79e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  836 YKIKPLLKSAETEKELATMKEDFVKCKEDLAKAEAKKKELE---------EKMVALLQEKNDLQLAVASESENLSDAEER 906
Cdd:PRK03918  301 FYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEelkkklkelEKRLEELEERHELYEEAKAKKEELERLKKR 380
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  907 CEGLIKSKIqlEAKLKETTERLEDEEEINAELTAKKRKLEDECSELKKDIDDLE-----LTLAKVEKEKHATEN------ 975
Cdd:PRK03918  381 LTGLTPEKL--EKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKkakgkCPVCGRELTEEHRKElleeyt 458
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  976 -KVKNLTEEMAAQDESIGKLTKEKKALQEA---------HQQTLDDLQAEEDKVNTLTKSktKLEQQVDDLEGSLEQEKK 1045
Cdd:PRK03918  459 aELKRIEKELKEIEEKERKLRKELRELEKVlkkeselikLKELAEQLKELEEKLKKYNLE--ELEKKAEEYEKLKEKLIK 536
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1046 LRMDLERAKRKLegdlklaqESIMDLENDKQQSEEKLKKKDFETSQLLSKIEDEQ-SLGAQLQKKIKELQARIEELEEEI 1124
Cdd:PRK03918  537 LKGEIKSLKKEL--------EKLEELKKKLAELEKKLDELEEELAELLKELEELGfESVEELEERLKELEPFYNEYLELK 608
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1125 EAERAARAKvEKQRADLSRELEEISERLEEAggataaqiemnkkrEAEFQKLRRDLEEstLQHEATAAALRKKQaDSVAE 1204
Cdd:PRK03918  609 DAEKELERE-EKELKKLEEELDKAFEELAET--------------EKRLEELRKELEE--LEKKYSEEEYEELR-EEYLE 670
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1205 LGEQIDNLQRVKQKLEKEKSEYKMEIDDLSSNMEAVAKAKANLEKMCRTLEDqLSEIKSK 1264
Cdd:PRK03918  671 LSRELAGLRAELEELEKRREEIKKTLEKLKEELEEREKAKKELEKLEKALER-VEELREK 729
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
841-1098 2.80e-07

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 55.84  E-value: 2.80e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   841 LLKSAETEKELATMKEDFVKCKEDLAKAEAKK--------KELEEKMVALLQEKNDLQLAVASE-----SENLSDAEERC 907
Cdd:TIGR02169  728 LEQEEEKLKERLEELEEDLSSLEQEIENVKSElkeleariEELEEDLHKLEEALNDLEARLSHSripeiQAELSKLEEEV 807
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   908 EGLIKSKIQLEAKLKETTERLEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAAQ 987
Cdd:TIGR02169  808 SRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDL 887
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   988 DESIGKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKSKTKLEQQVDDLEG-------------SLEQEKKLRMDLERAK 1054
Cdd:TIGR02169  888 KKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDpkgedeeipeeelSLEDVQAELQRVEEEI 967
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....
gi 288856329  1055 RKLEGDLKLAQESIMDLENDKQQSEEKLKKKDFETSQLLSKIED 1098
Cdd:TIGR02169  968 RALEPVNMLAIQEYEEVLKRLDELKEKRAKLEEERKAILERIEE 1011
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1641-1910 2.84e-07

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 55.84  E-value: 2.84e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1641 AQKQLRNVQAQLKDAQLHLDDAVRGQEDMKEQVAMVERRNTLMQSEIEELRAALEQTERGRKVAEQELVDASERVGLLHS 1720
Cdd:PRK03918  163 AYKNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEELKEEIEE 242
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1721 ---QNTSLLNTKKKLEADLVQIQSEVEDTVQEARNAEDKAKKAitdaammaEELKKEQDTSAHLERMKKNLEVtvkdlqh 1797
Cdd:PRK03918  243 lekELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKEL--------KELKEKAEEYIKLSEFYEEYLD------- 307
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1798 rldeaenlamkgGKKQLQKLESRVRELESEVEAEQRRGADAVKGVRKYERRVKELTYQTEEDKKNVNRLQDLVDKLQLKV 1877
Cdd:PRK03918  308 ------------ELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEELEERHELYEEAKAKKEELE 375
                         250       260       270
                  ....*....|....*....|....*....|...
gi 288856329 1878 KAYKRQSEEAEEQANSHLSKLRKVQHELEEAEE 1910
Cdd:PRK03918  376 RLKKRLTGLTPEKLEKELEELEKAKEEIEEEIS 408
PTZ00121 PTZ00121
MAEBL; Provisional
1621-1937 4.38e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 55.53  E-value: 4.38e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1621 EGDLNEMEIQLSHANRQAAEAQ-KQLRNVQAQLKDAQLHLDDAVRGQEDMKEQVAMVERRNTLMQSEIEELRAALEQTER 1699
Cdd:PTZ00121 1044 EKDIIDEDIDGNHEGKAEAKAHvGQDEGLKPSYKDFDFDAKEDNRADEATEEAFGKAEEAKKTETGKAEEARKAEEAKKK 1123
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1700 GRKVAEQELVDASERVgllhsqnTSLLNTKKKLEADLVQIQSEVEDT--VQEARNAED-----KAKKAITdaAMMAEELK 1772
Cdd:PTZ00121 1124 AEDARKAEEARKAEDA-------RKAEEARKAEDAKRVEIARKAEDArkAEEARKAEDakkaeAARKAEE--VRKAEELR 1194
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1773 KEQDTSA-----------HLERMKKNLEVTVKDLQHRLDEAENLAMKGGKKQLQKLESRVRELESEVEAEQRRGADAVKG 1841
Cdd:PTZ00121 1195 KAEDARKaeaarkaeeerKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKA 1274
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1842 VRKyeRRVKELTYQTEEDKKNVNRLQDLVDKL-QLKVKAY-KRQSEEAEEQANSHLSKLRKVQHELEEAEERADIAESQV 1919
Cdd:PTZ00121 1275 EEA--RKADELKKAEEKKKADEAKKAEEKKKAdEAKKKAEeAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEA 1352
                         330
                  ....*....|....*...
gi 288856329 1920 NKLRAKSRDSGKGKDAAE 1937
Cdd:PTZ00121 1353 EAAADEAEAAEEKAEAAE 1370
Macoilin pfam09726
Macoilin family; The Macoilin proteins has an N-terminal portion that is composed of 5 ...
1248-1494 5.92e-07

Macoilin family; The Macoilin proteins has an N-terminal portion that is composed of 5 trasnmembrane helices, followed by a C-terminal coiled-coil region. Macoilin is a highly conserved protein present in eukaryotes. Macoilin appears to be found in the ER and be involved in the function of neurons.


Pssm-ID: 462859 [Multi-domain]  Cd Length: 670  Bit Score: 54.47  E-value: 5.92e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1248 EKMCRtLEDQLSEIKS------KNDENLR-QINDLSAQRARLQTENGEFGRQLEEKEALVSQLTRGKQAFTQQIEELKRQ 1320
Cdd:pfam09726  395 DALVR-LEQDIKKLKAelqasrQTEQELRsQISSLTSLERSLKSELGQLRQENDLLQTKLHNAVSAKQKDKQTVQQLEKR 473
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1321 IEEEVKAKNALAHAVQSARHdcdllREQFEEEQEAKAELQRGMSKANSevaqwrtkyeTDAI-QRTEELEESKKKLAQRL 1399
Cdd:pfam09726  474 LKAEQEARASAEKQLAEEKK-----RKKEEEATAARAVALAAASRGEC----------TESLkQRKRELESEIKKLTHDI 538
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1400 QEAEEQIEAVNSKCASLEKTKQRlQGEVEDLMidveraNALAANLDKKQRNFDKVLAEWKQKYE------EGQAELEGAQ 1473
Cdd:pfam09726  539 KLKEEQIRELEIKVQELRKYKES-EKDTEVLM------SALSAMQDKNQHLENSLSAETRIKLDlfsalgDAKRQLEIAQ 611
                          250       260
                   ....*....|....*....|.
gi 288856329  1474 KEARSLSTELFKMKNSYEETL 1494
Cdd:pfam09726  612 GQIYQKDQEIKDLKQKIAEVM 632
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
1191-1923 6.75e-07

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 54.57  E-value: 6.75e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1191 AAALRKKQADSVAELGEQIDNLQRVKQKLEKEK-------SEYKMEIDDLSSNMEAVAKAkanlEKMCRTLEDqLSEIKS 1263
Cdd:COG3096   287 ALELRRELFGARRQLAEEQYRLVEMARELEELSaresdleQDYQAASDHLNLVQTALRQQ----EKIERYQED-LEELTE 361
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1264 KNDENLRQINDLSAQRARLQTEngeFGRQLEEKEALVSQLTRGKQAF-TQQIEELKRQieeevKAKNALahavQSARHDC 1342
Cdd:COG3096   362 RLEEQEEVVEEAAEQLAEAEAR---LEAAEEEVDSLKSQLADYQQALdVQQTRAIQYQ-----QAVQAL----EKARALC 429
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1343 ---DLLREQFEEEQEA-KAELQRG----------MSKANSEVAQWRTKYE-----TDAIQRTEELEESKKKLAQ--RLQE 1401
Cdd:COG3096   430 glpDLTPENAEDYLAAfRAKEQQAteevleleqkLSVADAARRQFEKAYElvckiAGEVERSQAWQTARELLRRyrSQQA 509
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1402 AEEQIEAVNSKCASLEKTKQRLQgevedlmidveRANALAANLDKKQR-------NFDKVLAEWKQKYEEGQAELEGAQK 1474
Cdd:COG3096   510 LAQRLQQLRAQLAELEQRLRQQQ-----------NAERLLEEFCQRIGqqldaaeELEELLAELEAQLEELEEQAAEAVE 578
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1475 EARSLstelfkmknsyEETLDQLETLKRENKN-------LQQEISDLTEQLGETGKSIHEL-EKSKKAVETEKaEIQTAL 1546
Cdd:COG3096   579 QRSEL-----------RQQLEQLRARIKELAArapawlaAQDALERLREQSGEALADSQEVtAAMQQLLERER-EATVER 646
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1547 EEAEGTLEHEESKILRVQL-------ELNQVK--------SEI-------------------------------DRKLAE 1580
Cdd:COG3096   647 DELAARKQALESQIERLSQpggaedpRLLALAerlggvllSEIyddvtledapyfsalygparhaivvpdlsavKEQLAG 726
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1581 KD---EEIEQIKRNSQRITDSMQSTLDSE----VRSRNDALRI----------KKKMEGDLNEMEIQLSHANRQAAEA-- 1641
Cdd:COG3096   727 LEdcpEDLYLIEGDPDSFDDSVFDAEELEdavvVKLSDRQWRYsrfpevplfgRAAREKRLEELRAERDELAEQYAKAsf 806
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1642 --QKQLRNVQAQLKDAQLHLDDAVrgQEDMKEQVAMVERRNTLMQSEIEELRAALEQtergrkvAEQELVDASERVGLLH 1719
Cdd:COG3096   807 dvQKLQRLHQAFSQFVGGHLAVAF--APDPEAELAALRQRRSELERELAQHRAQEQQ-------LRQQLDQLKEQLQLLN 877
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1720 SqntsLLNTKKKLEADlvqiqsEVEDTVQEARNAEDKAKKAitdaammAEELKKEQDTSAHLERMkknlevtVKDLQHRL 1799
Cdd:COG3096   878 K----LLPQANLLADE------TLADRLEELREELDAAQEA-------QAFIQQHGKALAQLEPL-------VAVLQSDP 933
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1800 DEAENLamkggKKQLQKLESRVRELeseveaeqRRGADAVKGVRKyerRVKELTYQTEEDKKNVNrlQDLVDKLQLKVKA 1879
Cdd:COG3096   934 EQFEQL-----QADYLQAKEQQRRL--------KQQIFALSEVVQ---RRPHFSYEDAVGLLGEN--SDLNEKLRARLEQ 995
                         810       820       830       840
                  ....*....|....*....|....*....|....*....|....
gi 288856329 1880 YKRQSEEAEEQANSHLSKLRKVQHELEEAEERADIAESQVNKLR 1923
Cdd:COG3096   996 AEEARREAREQLRQAQAQYSQYNQVLASLKSSRDAKQQTLQELE 1039
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1666-1899 7.26e-07

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 54.25  E-value: 7.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1666 QEDMKEQVAMVERRNTLMQSEIEELRAALEQTERgrKVA----EQELVDASERVGLLHSQNTSLLNTKKKLEADLVQIQS 1741
Cdd:COG3206   163 EQNLELRREEARKALEFLEEQLPELRKELEEAEA--ALEefrqKNGLVDLSEEAKLLLQQLSELESQLAEARAELAEAEA 240
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1742 EVeDTVQEARNAEDKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEV---TVKDLQHRLDEAEnlamkggkKQLQKLE 1818
Cdd:COG3206   241 RL-AALRAQLGSGPDALPELLQSPVIQQLRAQLAELEAELAELSARYTPnhpDVIALRAQIAALR--------AQLQQEA 311
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1819 SRVR-ELESEVEAEQRRGADAVKGVRKYERRVKELTyqteEDKKNVNRLQDLVDKLQLKVKAYKRQSEEAEEQANSHLSK 1897
Cdd:COG3206   312 QRILaSLEAELEALQAREASLQAQLAQLEARLAELP----ELEAELRRLEREVEVARELYESLLQRLEEARLAEALTVGN 387

                  ..
gi 288856329 1898 LR 1899
Cdd:COG3206   388 VR 389
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
875-1211 9.57e-07

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 54.15  E-value: 9.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  875 LEEKMVALLQEKNDLQLAVAsESENLSDAEERCEGLIKSKI---QLEAKLKETTERLEDEEEINAELtakkRKLEDECSE 951
Cdd:COG4913   622 LEEELAEAEERLEALEAELD-ALQERREALQRLAEYSWDEIdvaSAEREIAELEAELERLDASSDDL----AALEEQLEE 696
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  952 LKKDIDDLELTLAKVEKEKHATENKVKNLTEEmaaQDESIGKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKSKTKLEQ 1031
Cdd:COG4913   697 LEAELEELEEELDELKGEIGRLEKELEQAEEE---LDELQDRLEAAEDLARLELRALLEERFAAALGDAVERELRENLEE 773
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1032 QVDDLEGSLEQ-EKKLRMDLERAKRKLEGDLKLAQESIMDLEndkqqseeklkkkDFEtsQLLSKIEDEQsLgAQLQKKI 1110
Cdd:COG4913   774 RIDALRARLNRaEEELERAMRAFNREWPAETADLDADLESLP-------------EYL--ALLDRLEEDG-L-PEYEERF 836
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1111 KELQarieeleeeieaERAARAKVEKQRADLSRELEEISERLEEA---------GGATAAQIEMNKKREAEFQKLRRDLE 1181
Cdd:COG4913   837 KELL------------NENSIEFVADLLSKLRRAIREIKERIDPLndslkripfGPGRYLRLEARPRPDPEVREFRQELR 904
                         330       340       350
                  ....*....|....*....|....*....|
gi 288856329 1182 ESTLQHEATAAALRKKQADSVAELGEQIDN 1211
Cdd:COG4913   905 AVTSGASLFDEELSEARFAALKRLIERLRS 934
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
1086-1330 9.60e-07

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 53.30  E-value: 9.60e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1086 DFETSQLLSKIEDEQSLGAQLQKKIKELQARIEELEEEIEAERAARAKVEKQRADLSRELEEISERLEEaggataaqiem 1165
Cdd:COG3883    15 DPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEE----------- 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1166 nkkREAEFQKLRRDLEESTLQHEATAAALrkkQADSVAELGEQIDNLQRVKQKLEKEKSEYKMEIDDLSSNMEAVAKAKA 1245
Cdd:COG3883    84 ---RREELGERARALYRSGGSVSYLDVLL---GSESFSDFLDRLSALSKIADADADLLEELKADKAELEAKKAELEAKLA 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1246 NLEKMCRTLEDQLSEIKSKNDENLRQINDLSAQRARLQTENGEFGRQLEEKEALVSQLTRGKQAFTQQIEELKRQIEEEV 1325
Cdd:COG3883   158 ELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAA 237

                  ....*
gi 288856329 1326 KAKNA 1330
Cdd:COG3883   238 AAAAA 242
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
917-1405 1.21e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 53.77  E-value: 1.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  917 LEAKLKETTERLEDEEEINAELTAKKRKLEDECSELK--------KDIDDLELTLAKVEKEKHATENKVKNLTEEMAAQD 988
Cdd:COG4913   293 LEAELEELRAELARLEAELERLEARLDALREELDELEaqirgnggDRLEQLEREIERLERELEERERRRARLEALLAALG 372
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  989 ESIGKLTKEKKALQEAHQQTLDDLQAEEDKVNT----LTKSKTKLEQQVDDLEG---SLEQEK--------KLRMDLERA 1053
Cdd:COG4913   373 LPLPASAEEFAALRAEAAALLEALEEELEALEEalaeAEAALRDLRRELRELEAeiaSLERRKsniparllALRDALAEA 452
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1054 KRKLEGDLKLAQE--SIMDLENDKQQSEEKL----------KKKDFetSQLLSKIEDEQsLGAQLQkkIKELQARIEELE 1121
Cdd:COG4913   453 LGLDEAELPFVGEliEVRPEEERWRGAIERVlggfaltllvPPEHY--AAALRWVNRLH-LRGRLV--YERVRTGLPDPE 527
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1122 EEIEAERAARAKVE----KQRADLSRELEEIS-----ERLEEAGGATAA-----QIEMNKKReaeFQKLRRDLEEST--L 1185
Cdd:COG4913   528 RPRLDPDSLAGKLDfkphPFRAWLEAELGRRFdyvcvDSPEELRRHPRAitragQVKGNGTR---HEKDDRRRIRSRyvL 604
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1186 QHEATA--AALRKKQA---DSVAELGEQIDNLQRVKQKLEKEKSEYKM--EIDDLSSNMEAVAKAKANLEKMCRTLE--- 1255
Cdd:COG4913   605 GFDNRAklAALEAELAeleEELAEAEERLEALEAELDALQERREALQRlaEYSWDEIDVASAEREIAELEAELERLDass 684
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1256 DQLSEIKSKNDENLRQINDLSAQRARLQTENGEFGRQLEEKEALVSQLTRGKQAFTQQIEELKRQIEEEVKAKNALAHAV 1335
Cdd:COG4913   685 DDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALLEERFAAALGDAVE 764
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1336 QSARHDCDLLREQFEEEQE-AKAELQRGMSKANSE----VAQWRTKYET----DAI---QRTEELEESKKKLAQRLQEAE 1403
Cdd:COG4913   765 RELRENLEERIDALRARLNrAEEELERAMRAFNREwpaeTADLDADLESlpeyLALldrLEEDGLPEYEERFKELLNENS 844

                  ..
gi 288856329 1404 EQ 1405
Cdd:COG4913   845 IE 846
Filament pfam00038
Intermediate filament protein;
1267-1580 1.23e-06

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 52.62  E-value: 1.23e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1267 ENLRQINDLSA---QRAR-LQTENGEFGRQLEEKEALVS-QLTRGKQAFTQQIEELKRQIEEEVKAKnalahavqsarhd 1341
Cdd:pfam00038    4 EQLQELNDRLAsyiDKVRfLEQQNKLLETKISELRQKKGaEPSRLYSLYEKEIEDLRRQLDTLTVER------------- 70
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1342 cdllreqfeeeqeAKAELQRGmsKANSEVAQWRTKYETDAIQRTeELEESKKKLAQRLQEA-------EEQIEAVNSKCA 1414
Cdd:pfam00038   71 -------------ARLQLELD--NLRLAAEDFRQKYEDELNLRT-SAENDLVGLRKDLDEAtlarvdlEAKIESLKEELA 134
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1415 SLEKTKQ----RLQGEVEDLMIDVERANALAANLdkkqrnfDKVLAEWKQKYEEgQAELEGAQKEarslstelfkmknsy 1490
Cdd:pfam00038  135 FLKKNHEeevrELQAQVSDTQVNVEMDAARKLDL-------TSALAEIRAQYEE-IAAKNREEAE--------------- 191
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1491 eetldqlETLKRENKNLQQEISDLTEQLGETGKSIHELEKSKKAVETE-------KAEIQTALEEAEGTLEHE----ESK 1559
Cdd:pfam00038  192 -------EWYQSKLEELQQAAARNGDALRSAKEEITELRRTIQSLEIElqslkkqKASLERQLAETEERYELQladyQEL 264
                          330       340
                   ....*....|....*....|.
gi 288856329  1560 ILRVQLELNQVKSEIDRKLAE 1580
Cdd:pfam00038  265 ISELEAELQETRQEMARQLRE 285
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
884-1548 1.25e-06

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 53.69  E-value: 1.25e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   884 QEKNDLQLAVASE-SENLSDAEERCEGLIKSKIQLEAKLKETTERLEdeEEINAELTAKKRKLEDECSELKKDIDDLELT 962
Cdd:pfam12128  375 AKYNRRRSKIKEQnNRDIAGIKDKLAKIREARDRQLAVAEDDLQALE--SELREQLEAGKLEFNEEEYRLKSRLGELKLR 452
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   963 LAKVEKEKHATENKvKNLTEEMAAQDESIGKLTKEKKALQE-------AHQQTLDDLQAEEDKVNTLTKSKTKLEQQVDD 1035
Cdd:pfam12128  453 LNQATATPELLLQL-ENFDERIERAREEQEAANAEVERLQSelrqarkRRDQASEALRQASRRLEERQSALDELELQLFP 531
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1036 LEGSLEQekklrmdlerakrKLEGDLKLAQESImdlenDKQQSEEKLKKKDFETSQLLSKIEDEQSL-GAQLQ-KKI--- 1110
Cdd:pfam12128  532 QAGTLLH-------------FLRKEAPDWEQSI-----GKVISPELLHRTDLDPEVWDGSVGGELNLyGVKLDlKRIdvp 593
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1111 ------KELQARIEELEEEIEAERAARAKVEKQRADLSRELEEISERLEEAGGAtaaqiemnkkreaeFQKLRRDLEEST 1184
Cdd:pfam12128  594 ewaaseEELRERLDKAEEALQSAREKQAAAEEQLVQANGELEKASREETFARTA--------------LKNARLDLRRLF 659
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1185 LQHEATAAALRKKQADSVAELGEQIDNLQRVKQKLEKEKSEYKMEIDDLSSnmEAVAKAKANLEKMCRTLEDQLSEIKSK 1264
Cdd:pfam12128  660 DEKQSEKDKKNKALAERKDSANERLNSLEAQLKQLDKKHQAWLEEQKEQKR--EARTEKQAYWQVVEGALDAQLALLKAA 737
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1265 NDEnlRQINdLSAQRARLQTENGEFGRQLEEKEALVSQLTRGKQAFTQQIEELKRQieeevkaknalAHAVQSARhdcDL 1344
Cdd:pfam12128  738 IAA--RRSG-AKAELKALETWYKRDLASLGVDPDVIAKLKREIRTLERKIERIAVR-----------RQEVLRYF---DW 800
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1345 LREQFEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEESKK---KLAQRLQEAEEQIEAVNSKCASL--EKT 1419
Cdd:pfam12128  801 YQETWLQRRPRLATQLSNIERAISELQQQLARLIADTKLRRAKLEMERKaseKQQVRLSENLRGLRCEMSKLATLkeDAN 880
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1420 KQRLQGE-------VEDLMIDVERanaLAANLDKKQRNFDKVLAEwkqKYEEGQAEL-EGAQKEARSLSTELFKMKNsYE 1491
Cdd:pfam12128  881 SEQAQGSigerlaqLEDLKLKRDY---LSESVKKYVEHFKNVIAD---HSGSGLAETwESLREEDHYQNDKGIRLLD-YR 953
                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 288856329  1492 ETLDQLETLKreNKNLQQEISDLTEQLGETGKSIHE----LEKSKKAVETEKAEIQTALEE 1548
Cdd:pfam12128  954 KLVPYLEQWF--DVRVPQSIMVLREQVSILGVDLTEfydvLADFDRRIASFSRELQREVGE 1012
PRK10246 PRK10246
exonuclease subunit SbcC; Provisional
964-1661 1.26e-06

exonuclease subunit SbcC; Provisional


Pssm-ID: 182330 [Multi-domain]  Cd Length: 1047  Bit Score: 53.65  E-value: 1.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  964 AKVEKEK-HATENKVKNLTEEMAAQ-DESIGKLTKEKKAL---QEAHQQTLDDLQAEEDKVNTLTKSKTKLEQQVDDLEG 1038
Cdd:PRK10246  196 ARTELEKlQAQASGVALLTPEQVQSlTASLQVLTDEEKQLltaQQQQQQSLNWLTRLDELQQEASRRQQALQQALAAEEK 275
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1039 SLEQEKKLrmDLERAKRKLEGDLKLAQESIMDLENDKQQSEEKlkkkdfeTSQLLSKIEDEQSLGAQLQKKIKELQArie 1118
Cdd:PRK10246  276 AQPQLAAL--SLAQPARQLRPHWERIQEQSAALAHTRQQIEEV-------NTRLQSTMALRARIRHHAAKQSAELQA--- 343
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1119 eleeeieaeraarakvekQRADLSRELEEiSERLEEAGGATA---AQIEMNKKREAEFQKLRRDLEESTLQHEATAAALR 1195
Cdd:PRK10246  344 ------------------QQQSLNTWLAE-HDRFRQWNNELAgwrAQFSQQTSDREQLRQWQQQLTHAEQKLNALPAITL 404
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1196 KKQADSVAELGEQIDNLQRVKQKLEKEKSEYKMEIDDLSSNMEAVAKAKANLEKMCRTLEDQLSEIKSKNDENLR----- 1270
Cdd:PRK10246  405 TLTADEVAAALAQHAEQRPLRQRLVALHGQIVPQQKRLAQLQVAIQNVTQEQTQRNAALNEMRQRYKEKTQQLADvktic 484
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1271 ----QINDLSAQRARLQTengefGRQLEEKEALVSQLTRGKQAFTQQIEELKR-QIEEEVKaknALAHAVQSARHDCDLL 1345
Cdd:PRK10246  485 eqeaRIKDLEAQRAQLQA-----GQPCPLCGSTSHPAVEAYQALEPGVNQSRLdALEKEVK---KLGEEGAALRGQLDAL 556
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1346 REQFeeeQEAKAELQRGMSKANSEVAQWRTKYETDAIQRT------------EELEESKKKLAQRLQ---EAEEQIEAVN 1410
Cdd:PRK10246  557 TKQL---QRDESEAQSLRQEEQALTQQWQAVCASLNITLQpqddiqpwldaqEEHERQLRLLSQRHElqgQIAAHNQQII 633
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1411 SKCASLEKTKQRLQGEVEDLMIDVERANALAANLDKKQRNFdkvlAEWKQKYEEgQAELEGAQKEARSLSTELFKMKNSY 1490
Cdd:PRK10246  634 QYQQQIEQRQQQLLTALAGYALTLPQEDEEASWLATRQQEA----QSWQQRQNE-LTALQNRIQQLTPLLETLPQSDDLP 708
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1491 EE----TLDQLETLKRENKNLQQEISDLTEQLGETGKSIHELEKS-----KKAVETEKAEIQTALEEAEgTLEHEESKIL 1561
Cdd:PRK10246  709 HSeetvALDNWRQVHEQCLSLHSQLQTLQQQDVLEAQRLQKAQAQfdtalQASVFDDQQAFLAALLDEE-TLTQLEQLKQ 787
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1562 RVQLELNQVKSeidrkLAEKDEeiEQIKRNSQRITDSMQSTLDSE-----VRSRNDALRIKKKMEGDLNEmeiQLshanR 1636
Cdd:PRK10246  788 NLENQRQQAQT-----LVTQTA--QALAQHQQHRPDGLDLTVTVEqiqqeLAQLAQQLRENTTRQGEIRQ---QL----K 853
                         730       740
                  ....*....|....*....|....*
gi 288856329 1637 QAAEAQKQLRNVQAQLKDAQLHLDD 1661
Cdd:PRK10246  854 QDADNRQQQQALMQQIAQATQQVED 878
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1040-1493 1.33e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 53.62  E-value: 1.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1040 LEQEKKLRMDLERAKRKLEGDLKLAQESIMDLENDKQQSEEKLKKKDfetsQLLSKIEDEQSLgAQLQKKIKELQARIEE 1119
Cdd:COG4717    76 LEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLE----KLLQLLPLYQEL-EALEAELAELPERLEE 150
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1120 LEEEIEAERAARAKVEKQRADLSRELEEISERLEEAGGATAAQIEMNKKREAEFQKLRRDLEESTLQHEATAAALRKKQA 1199
Cdd:COG4717   151 LEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELE 230
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1200 DSVAELgeqidNLQRVKQKLEKEKSEYK------------MEIDDLSSNMEAVAKAKANLekmcrtLEDQLSEIKSKNDE 1267
Cdd:COG4717   231 QLENEL-----EAAALEERLKEARLLLLiaaallallglgGSLLSLILTIAGVLFLVLGL------LALLFLLLAREKAS 299
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1268 NLRQINDLSAQRARLQTENGEFGRQLEEKEALVSQLTRGKQAFTQQIEELKRQIEEEVKAKNALAHAVQSARHDCDLLRE 1347
Cdd:COG4717   300 LGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEELEQEIAALLAEA 379
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1348 QFEEEQE--AKAELQRGMSKANSEVAQWRTKYETDAIQRTEELE-ESKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQ 1424
Cdd:COG4717   380 GVEDEEElrAALEQAEEYQELKEELEELEEQLEELLGELEELLEaLDEEELEEELEELEEELEELEEELEELREELAELE 459
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 288856329 1425 GEVEDLMIDVEranalaanldkkqrnfdkvLAEWKQKYEEGQAELEGAQKEARSLSTELFKMKNSYEET 1493
Cdd:COG4717   460 AELEQLEEDGE-------------------LAELLQELEELKAELRELAEEWAALKLALELLEEAREEY 509
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1104-1339 1.46e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 52.84  E-value: 1.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1104 AQLQKKIKELQARIEELEEEIEAERAARAKVEKQRADLSRELEEISERLEEAggataaqiemnkkrEAEFQKLRRDLEES 1183
Cdd:COG4942    23 AEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRAL--------------EQELAALEAELAEL 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1184 TLQHEATAAALRKKQAdsvaELGEQIDNLQRVKQKLEKE---KSEYKMEIDDLSSNMEAVAKA-KANLEKMCRT---LED 1256
Cdd:COG4942    89 EKEIAELRAELEAQKE----ELAELLRALYRLGRQPPLAlllSPEDFLDAVRRLQYLKYLAPArREQAEELRADlaeLAA 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1257 QLSEIKSKNDENLRQINDLSAQRARLQtengefgRQLEEKEALVSQLTRGKQAFTQQIEELKRQIEEEVKAKNALAHAVQ 1336
Cdd:COG4942   165 LRAELEAERAELEALLAELEEERAALE-------ALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAA 237

                  ...
gi 288856329 1337 SAR 1339
Cdd:COG4942   238 AAA 240
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1294-1777 1.50e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 53.23  E-value: 1.50e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1294 EEKEALVSQLTRGKQAFTQQIEELKRQIEEEvKAKNALAHAVQSARHDcdlLREQFEEEQEAKAELQRGMSKANSEVAQW 1373
Cdd:COG4717    53 KEADELFKPQGRKPELNLKELKELEEELKEA-EEKEEEYAELQEELEE---LEEELEELEAELEELREELEKLEKLLQLL 128
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1374 rtkyetDAIQRTEELEESKKKLAQRLQEAEEQIEAVnskcASLEKTKQRLQGEVEDLMIDVERANALAANLDKKQrnfdk 1453
Cdd:COG4717   129 ------PLYQELEALEAELAELPERLEELEERLEEL----RELEEELEELEAELAELQEELEELLEQLSLATEEE----- 193
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1454 vLAEWKQKYEEGQAELEGAQKEARSLSTELfkmknsyeetldqlETLKRENKNL--QQEISDLTEQLGETGKS------I 1525
Cdd:COG4717   194 -LQDLAEELEELQQRLAELEEELEEAQEEL--------------EELEEELEQLenELEAAALEERLKEARLLlliaaaL 258
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1526 HELEKSKKAVETEKAEIQTALEEAEGTLEHEESKILRVQLELNQVKSEIDRKLAEKDEEIEQIKRNSQRITDSmQSTLDS 1605
Cdd:COG4717   259 LALLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLP-PDLSPE 337
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1606 EVRSRNDALRIKKKMEGDLNEMEIQLSHANRQaAEAQKQLRNVQAQLKDAQLHLDDAVRGQEDMKEQVAMVERR------ 1679
Cdd:COG4717   338 ELLELLDRIEELQELLREAEELEEELQLEELE-QEIAALLAEAGVEDEEELRAALEQAEEYQELKEELEELEEQleellg 416
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1680 ---NTLMQSEIEELRAALEQTERGRKVAEQELVDASERVGLLHSQNTSLLNtkkklEADLVQIQSEVEDTVQEARNAEDK 1756
Cdd:COG4717   417 eleELLEALDEEELEEELEELEEELEELEEELEELREELAELEAELEQLEE-----DGELAELLQELEELKAELRELAEE 491
                         490       500
                  ....*....|....*....|.
gi 288856329 1757 AKKAITDAAMMAEELKKEQDT 1777
Cdd:COG4717   492 WAALKLALELLEEAREEYREE 512
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1418-1898 1.83e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 52.85  E-value: 1.83e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1418 KTKQRLQGEVEDLMIDVERANALAANLDKKQRNfdkvLAEWKQKYEEGQAELEGAQKEARSLSTELfkmknSYEETLDQL 1497
Cdd:COG4717    64 RKPELNLKELKELEEELKEAEEKEEEYAELQEE----LEELEEELEELEAELEELREELEKLEKLL-----QLLPLYQEL 134
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1498 ETLKRENKNLQQEISDLTEQLGETGKSIHELEKSKKAVETEKAEIQTALEEAEGTLEHEESKILRVQLELNQVKSEIDRK 1577
Cdd:COG4717   135 EALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEE 214
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1578 LAEKDEEIEQIKRNSQRITDSMQSTLDSEVRSRNDALRIkkkmegDLNEMEIQLSHANRQAAEAQKQLRNVQAQLKDAQL 1657
Cdd:COG4717   215 LEEAQEELEELEEELEQLENELEAAALEERLKEARLLLL------IAAALLALLGLGGSLLSLILTIAGVLFLVLGLLAL 288
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1658 HLDDAVRGQEDMKEQVAMVERRNTLMQSEIEELRAALEQTERGRKVAEQELVDASERVGLLHSQNTSLLNTKKklEADLV 1737
Cdd:COG4717   289 LFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEE--ELQLE 366
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1738 QIQSEVEDTVQEArNAEDKAkkAITDAAMMAEELKKEQDTSAHLERMKKNLEVTVKDLQHRLDEAENlamkggKKQLQKL 1817
Cdd:COG4717   367 ELEQEIAALLAEA-GVEDEE--ELRAALEQAEEYQELKEELEELEEQLEELLGELEELLEALDEEEL------EEELEEL 437
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1818 ESRVRELESEVEAEQRRGADAVKGVRKYE--RRVKELTYQTEEDKKNVNRLQDLVDKLQLKVKAYKRQSEEAEE------ 1889
Cdd:COG4717   438 EEELEELEEELEELREELAELEAELEQLEedGELAELLQELEELKAELRELAEEWAALKLALELLEEAREEYREerlppv 517
                         490
                  ....*....|.
gi 288856329 1890 --QANSHLSKL 1898
Cdd:COG4717   518 leRASEYFSRL 528
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
944-1611 2.25e-06

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 53.13  E-value: 2.25e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   944 KLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAAQDESIGKLTKEKKALQ--EAHQQTLDDLQAEEDKVNT 1021
Cdd:TIGR01612 1108 KYADEINKIKDDIKNLDQKIDHHIKALEEIKKKSENYIDEIKAQINDLEDVADKAISNDdpEEIEKKIENIVTKIDKKKN 1187
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1022 LTKSKTKLEQQVDDLEG---SLEQEKKLRMD------------LERAKRKLEGDLKLAQESIMDLENDKQQSEEklkkkd 1086
Cdd:TIGR01612 1188 IYDEIKKLLNEIAEIEKdktSLEEVKGINLSygknlgklflekIDEEKKKSEHMIKAMEAYIEDLDEIKEKSPE------ 1261
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1087 fetsqllskIEDEQSLGAQLQKKIKELQARIEeleeeieaeraaraKVEKQRADLSRELEEISERLEEAggataAQIEMN 1166
Cdd:TIGR01612 1262 ---------IENEMGIEMDIKAEMETFNISHD--------------DDKDHHIISKKHDENISDIREKS-----LKIIED 1313
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1167 KKREAEFQKLRRDLEESTLQHEataaalrKKQADSVAELGE-----QIDNLQRVKQKLEKEKsEYKMEIDDLSSNmeaVA 1241
Cdd:TIGR01612 1314 FSEESDINDIKKELQKNLLDAQ-------KHNSDINLYLNEianiyNILKLNKIKKIIDEVK-EYTKEIEENNKN---IK 1382
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1242 KAKANLEKMCRTLED--QLSEIKSKN---------DENLRQINDLSAQRARLQTENGEFGRQLEEKEALVSQLTRgkqaf 1310
Cdd:TIGR01612 1383 DELDKSEKLIKKIKDdiNLEECKSKIestlddkdiDECIKKIKELKNHILSEESNIDTYFKNADENNENVLLLFK----- 1457
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1311 TQQIEELKRQIEEEVKAKNAlahavqSARHDCDLlreqfeeeqeakAELQRGMSKANsevaqwrtKYETDAIQRTEELEE 1390
Cdd:TIGR01612 1458 NIEMADNKSQHILKIKKDNA------TNDHDFNI------------NELKEHIDKSK--------GCKDEADKNAKAIEK 1511
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1391 SKKKLAQRLQEAEEQIE-----AVNSKCASLEKTKQRLQGEVEDLMIDVERANALAANLDKKQRNFDKVLAEWKQKYEEG 1465
Cdd:TIGR01612 1512 NKELFEQYKKDVTELLNkysalAIKNKFAKTKKDSEIIIKEIKDAHKKFILEAEKSEQKIKEIKKEKFRIEDDAAKNDKS 1591
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1466 QAELEGAQKEARSLSTELFKMKNSYEETLDQLetlkRENKNLQQEISDLT-----EQLGETGKSIHELEKSKKAVETEKA 1540
Cdd:TIGR01612 1592 NKAAIDIQLSLENFENKFLKISDIKKKINDCL----KETESIEKKISSFSidsqdTELKENGDNLNSLQEFLESLKDQKK 1667
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 288856329  1541 EIqtalEEAEGTLEHEESKILRVQLELNQVKSEIDRKLAEKDEEIEQIKRNS-QRITDSMQSTLDSEVRSRN 1611
Cdd:TIGR01612 1668 NI----EDKKKELDELDSEIEKIEIDVDQHKKNYEIGIIEKIKEIAIANKEEiESIKELIEPTIENLISSFN 1735
Laminin_I pfam06008
Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from ...
1313-1553 3.00e-06

Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.


Pssm-ID: 310534 [Multi-domain]  Cd Length: 258  Bit Score: 50.87  E-value: 3.00e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1313 QIEELKRQIEEEVKAKNALAHAVQSARHDCDLLREQFEEEQEAKAELQRGMSKANSEVaqwrtkyeTDAIQRTEELEESK 1392
Cdd:pfam06008   20 NLENLTKQLQEYLSPENAHKIQIEILEKELSSLAQETEELQKKATQTLAKAQQVNAES--------ERTLGHAKELAEAI 91
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1393 KKLAQRLQEAEEQIEAVNSKCASL-EKTKQRLQGEVEDLMIDVEranalAANLDKKQRNFDKVLAEWKQKYEEGQAELEG 1471
Cdd:pfam06008   92 KNLIDNIKEINEKVATLGENDFALpSSDLSRMLAEAQRMLGEIR-----SRDFGTQLQNAEAELKAAQDLLSRIQTWFQS 166
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1472 AQKEARSLSTELFKMKNSYEETLDQLETLKRENKNLQQEISDLteqLGETGKSIHELEKSKKAVETEKAEIQTALEEAEG 1551
Cdd:pfam06008  167 PQEENKALANALRDSLAEYEAKLSDLRELLREAAAKTRDANRL---NLANQANLREFQRKKEEVSEQKNQLEETLKTARD 243

                   ..
gi 288856329  1552 TL 1553
Cdd:pfam06008  244 SL 245
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1479-1715 3.20e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 51.69  E-value: 3.20e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1479 LSTELFKMKNSYEETLDQLETLKRENKNLQQEISDLTEQLGETGKSIHELEKSKKAVETEKAEIQTALEEAEGTLEhees 1558
Cdd:COG4942    11 LALAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELA---- 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1559 kilrvqlELNQVKSEIDRKLAEKDEEIEQIKRNSQRITD--------SMQSTLDSEVRSR--NDALRIKKKMEGDLNEME 1628
Cdd:COG4942    87 -------ELEKEIAELRAELEAQKEELAELLRALYRLGRqpplalllSPEDFLDAVRRLQylKYLAPARREQAEELRADL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1629 IQLSHANRQAAEAQKQLRNVQAQLKDAQLHLDDAVRGQEDMkeqVAMVERRNTLMQSEIEELRAALEQTERGRKVAEQEL 1708
Cdd:COG4942   160 AELAALRAELEAERAELEALLAELEEERAALEALKAERQKL---LARLEKELAELAAELAELQQEAEELEALIARLEAEA 236

                  ....*..
gi 288856329 1709 VDASERV 1715
Cdd:COG4942   237 AAAAERT 243
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
1621-1838 3.77e-06

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 51.37  E-value: 3.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1621 EGDLNEMEIQLSHANRQAAEAQKQLRNVQAQLKDAQLHLDDAVRGQEDMKEQVAMVERRNTLMQSEIEELRAALEQT--- 1697
Cdd:COG3883    15 DPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERara 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1698 --ERGRKVAE----------QELVDASERVGLLHSQNTSLLNTKKKLEADLVQIQSEVEDTVQEARNAEDKAKKAITDaa 1765
Cdd:COG3883    95 lyRSGGSVSYldvllgsesfSDFLDRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAE-- 172
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 288856329 1766 mmAEELKKEQdtsahlERMKKNLEVTVKDLQHRLDEAENLAMKGGKKQLQKLESRVRELESEVEAEQRRGADA 1838
Cdd:COG3883   173 --LEAQQAEQ------EALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAA 237
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
1105-1429 4.43e-06

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 51.66  E-value: 4.43e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1105 QLQKKIKELQARIEELEEEIEaeraaraKVEKQRADLSRELEEiSERLEEAGGATAAQIEMNKKREAEFQKL--RRDLEE 1182
Cdd:pfam17380  279 QHQKAVSERQQQEKFEKMEQE-------RLRQEKEEKAREVER-RRKLEEAEKARQAEMDRQAAIYAEQERMamEREREL 350
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1183 STLQHEATAAALRKKQADSVAELGEQIDNLQRVKQKLEKEKSEYKMEiddlssnMEAVAKAKANLEKMCRTLEDQLSEIK 1262
Cdd:pfam17380  351 ERIRQEERKRELERIRQEEIAMEISRMRELERLQMERQQKNERVRQE-------LEAARKVKILEEERQRKIQQQKVEME 423
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1263 S--KNDENLRQIndlsaqrarlqtengEFGRQLEEKEALVSQLTRGKQAFTQQIEELKRQIEEEVKAKNALAHAVQSARH 1340
Cdd:pfam17380  424 QirAEQEEARQR---------------EVRRLEEERAREMERVRLEEQERQQQVERLRQQEEERKRKKLELEKEKRDRKR 488
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1341 DCDLLREQFEEEQEAKAE-----------LQRGMSKANSEVAQWRTKYETDAIQRTEELEESKKKLAQRLQEAEEQieav 1409
Cdd:pfam17380  489 AEEQRRKILEKELEERKQamieeerkrklLEKEMEERQKAIYEEERRREAEEERRKQQEMEERRRIQEQMRKATEE---- 564
                          330       340
                   ....*....|....*....|
gi 288856329  1410 NSKCASLEKTKQRLQGEVED 1429
Cdd:pfam17380  565 RSRLEAMEREREMMRQIVES 584
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
891-1105 4.73e-06

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 50.98  E-value: 4.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  891 LAVASESENLSDAEERCEGLIKSKIQLEAKLKETTERLED-EEEINaELTAKKRKLEDECSELKKDIDDLELTLAKVEKE 969
Cdd:COG3883     2 LALALAAPTPAFADPQIQAKQKELSELQAELEAAQAELDAlQAELE-ELNEEYNELQAELEALQAEIDKLQAEIAEAEAE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  970 KHATENKVKNLTEEMAAQDESIGKLTkekkALQEAhqQTLDDL-----------QAEEDKVNTLTKSKTKLEQQVDDLEG 1038
Cdd:COG3883    81 IEERREELGERARALYRSGGSVSYLD----VLLGS--ESFSDFldrlsalskiaDADADLLEELKADKAELEAKKAELEA 154
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 288856329 1039 SLEQEKKLRMDLERAKRKLEGDLKLAQESIMDLENDKQQSEEKLKKKDFETSQLLSKIEDEQSLGAQ 1105
Cdd:COG3883   155 KLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAA 221
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
1164-1878 4.96e-06

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 51.98  E-value: 4.96e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1164 EMNKKREAEFQKLRRDLEESTLQHEATAAALRKKQADSVAELGEQIDNlqRVKQKLEKEKSEYKMEIDDLSSNMEAVAKA 1243
Cdd:TIGR01612  700 DLKSKIDKEYDKIQNMETATVELHLSNIENKKNELLDIIVEIKKHIHG--EINKDLNKILEDFKNKEKELSNKINDYAKE 777
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1244 KANLEKMcrtlEDQLSEIKSK-NDE-NLRQINDLSAQRARLQTEngEFGRQLEEKEALVSQLtrgkqaftqqIEELKRQI 1321
Cdd:TIGR01612  778 KDELNKY----KSKISEIKNHyNDQiNIDNIKDEDAKQNYDKSK--EYIKTISIKEDEIFKI----------INEMKFMK 841
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1322 EEEVKAKNALAHAVQSARHDCDLLREQFEE-EQEAKAELqrgmskANSEVAQWRTKYeTDAIQRTEELEESKKKLAQR-- 1398
Cdd:TIGR01612  842 DDFLNKVDKFINFENNCKEKIDSEHEQFAElTNKIKAEI------SDDKLNDYEKKF-NDSKSLINEINKSIEEEYQNin 914
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1399 -LQEAEEQIEAVNSKCASLEK--TKQRLQGEVEDLMIDVERANALAANLDKKQrnFDKVLAEWKQKYEEGQAELEGAQKE 1475
Cdd:TIGR01612  915 tLKKVDEYIKICENTKESIEKfhNKQNILKEILNKNIDTIKESNLIEKSYKDK--FDNTLIDKINELDKAFKDASLNDYE 992
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1476 ARSlsTELFKMKNSYEETL---------DQLETLKRENKNLQQEISDLTEQLGETGKSIH--------ELEKS-KKAVET 1537
Cdd:TIGR01612  993 AKN--NELIKYFNDLKANLgknkenmlyHQFDEKEKATNDIEQKIEDANKNIPNIEIAIHtsiyniidEIEKEiGKNIEL 1070
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1538 EKAEIqtaLEEAEGTLEHeeskilrvqleLNQVKSEIDRKLAEKDEEIEQIKRNSQ--RITDSMQsTLDSEVRSRNDAL- 1614
Cdd:TIGR01612 1071 LNKEI---LEEAEINITN-----------FNEIKEKLKHYNFDDFGKEENIKYADEinKIKDDIK-NLDQKIDHHIKALe 1135
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1615 RIKKKMEGDLNEMEIQLSHANRQAAEA--QKQLRNVQAQLKDAQLHLDDAVRGQEDMKEQVAMVerrntlmqSEIEELRA 1692
Cdd:TIGR01612 1136 EIKKKSENYIDEIKAQINDLEDVADKAisNDDPEEIEKKIENIVTKIDKKKNIYDEIKKLLNEI--------AEIEKDKT 1207
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1693 ALEQTERGRKVAEQELVDAS-ERVGLLHSQNTSLLNTKKKLEADLVQIQSEVEDTVQEARNAEDkakkaiTDAAMMAEEL 1771
Cdd:TIGR01612 1208 SLEEVKGINLSYGKNLGKLFlEKIDEEKKKSEHMIKAMEAYIEDLDEIKEKSPEIENEMGIEMD------IKAEMETFNI 1281
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1772 KKEQDTSAHLERMKKNLEVT---VKDLQHRLDEAENLAMKGGKKQLQKLESRVRELESEVEAEQRRGAD-----AVKGVR 1843
Cdd:TIGR01612 1282 SHDDDKDHHIISKKHDENISdirEKSLKIIEDFSEESDINDIKKELQKNLLDAQKHNSDINLYLNEIANiynilKLNKIK 1361
                          730       740       750
                   ....*....|....*....|....*....|....*
gi 288856329  1844 KYERRVKELTYQTEEDKKNVNRLQDLVDKLQLKVK 1878
Cdd:TIGR01612 1362 KIIDEVKEYTKEIEENNKNIKDELDKSEKLIKKIK 1396
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
927-1326 5.35e-06

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 51.75  E-value: 5.35e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   927 RLEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAAQDESIGKLTKEKKALQEAHQ 1006
Cdd:pfam10174  353 RLEEKESFLNKKTKQLQDLTEEKSTLAGEIRDLKDMLDVKERKINVLQKKIENLQEQLRDKDKQLAGLKERVKSLQTDSS 432
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1007 Q------TLDDLQAEEDKV-NTLTKSKTKLEQQVDDlegSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDLENDKQQSE 1079
Cdd:pfam10174  433 NtdtaltTLEEALSEKERIiERLKEQREREDRERLE---ELESLKKENKDLKEKVSALQPELTEKESSLIDLKEHASSLA 509
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1080 EKLKKKDFETSQLLSKIEDEQSLGAQLQ---KKIKELQARIEELEEEIEAERAARAKVEKQRADLSRELEEIsERLEEAG 1156
Cdd:pfam10174  510 SSGLKKDSKLKSLEIAVEQKKEECSKLEnqlKKAHNAEEAVRTNPEINDRIRLLEQEVARYKEESGKAQAEV-ERLLGIL 588
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1157 GATAAQIEMNKKREAEFQKLR----RDLEESTLQHEATAAALRKKQADSVAELGEQIDNLQRVKQK---------LEKEK 1223
Cdd:pfam10174  589 REVENEKNDKDKKIAELESLTlrqmKEQNKKVANIKHGQQEMKKKGAQLLEEARRREDNLADNSQQlqleelmgaLEKTR 668
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1224 SEYKMEIDDLSSNMEAVAKAKANLEKMCRTLEDQLSEI-KSKNDENLRQINDLSAQRARLQTENGEFGRQLEEkealVSQ 1302
Cdd:pfam10174  669 QELDATKARLSSTQQSLAEKDGHLTNLRAERRKQLEEIlEMKQEALLAAISEKDANIALLELSSSKKKKTQEE----VMA 744
                          410       420
                   ....*....|....*....|....
gi 288856329  1303 LTRGKQAFTQQieeLKRQIEEEVK 1326
Cdd:pfam10174  745 LKREKDRLVHQ---LKQQTQNRMK 765
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
1003-1187 5.46e-06

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 49.92  E-value: 5.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1003 EAHQQTLDDLQAEEDKVNTLTKSKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDLENDKQQSEEKL 1082
Cdd:COG1579     3 PEDLRALLDLQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1083 KK----KDFEtsQLLSKIEDEQSLGAQLQKKIKELQarieeleEEIEAERAARAKVEKQRADLSRELEEISERLEEAGGA 1158
Cdd:COG1579    83 GNvrnnKEYE--ALQKEIESLKRRISDLEDEILELM-------ERIEELEEELAELEAELAELEAELEEKKAELDEELAE 153
                         170       180
                  ....*....|....*....|....*....
gi 288856329 1159 TAAQIEmnkKREAEFQKLRRDLEESTLQH 1187
Cdd:COG1579   154 LEAELE---ELEAEREELAAKIPPELLAL 179
Motor_domain cd01363
Myosin and Kinesin motor domain; Myosin and Kinesin motor domain. These ATPases belong to the ...
650-677 5.91e-06

Myosin and Kinesin motor domain; Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes. Some of the names do not match with what is given in the sequence list. This is because they are based on the current nomenclature by Kollmar/Sebe-Pedros.


Pssm-ID: 276814 [Multi-domain]  Cd Length: 170  Bit Score: 48.50  E-value: 5.91e-06
                          10        20
                  ....*....|....*....|....*...
gi 288856329  650 SSQFRENLGKLMTNLRSTHPHFVRCLIP 677
Cdd:cd01363   143 FEIINESLNTLMNVLRATRPHFVRCISP 170
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
893-1907 6.07e-06

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 51.59  E-value: 6.07e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   893 VASESENLSDAEERCEGLIKSKIqlEAKLKETTERLEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKE--- 969
Cdd:TIGR01612  520 VPSKNIIGFDIDQNIKAKLYKEI--EAGLKESYELAKNWKKLIHEIKKELEEENEDSIHLEKEIKDLFDKYLEIDDEiiy 597
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   970 ----KHATENKVKNLTEE-------------MAAQDESIGKLTKE-------------------KKALQEAHQQTLDDLQ 1013
Cdd:TIGR01612  598 inklKLELKEKIKNISDKneyikkaidlkkiIENNNAYIDELAKIspyqvpehlknkdkiystiKSELSKIYEDDIDALY 677
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1014 AE-------------EDKVNtLTKSKTKLEQQVDDLEGSLEQEKKLRM-DLERAKRKLEGDLKLAQESIM-DLENDKQQS 1078
Cdd:TIGR01612  678 NElssivkenaidntEDKAK-LDDLKSKIDKEYDKIQNMETATVELHLsNIENKKNELLDIIVEIKKHIHgEINKDLNKI 756
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1079 EEKLKKKDfetSQLLSKIEDEQSLGAQLQK---KIKELQARIEELEEEIEAERAARakveKQRADLSRELEEISERLEEA 1155
Cdd:TIGR01612  757 LEDFKNKE---KELSNKINDYAKEKDELNKyksKISEIKNHYNDQINIDNIKDEDA----KQNYDKSKEYIKTISIKEDE 829
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1156 GGATAAQIEMNK----KREAEFQKLRRDLEESTLQHEATAAALRKKQADSVAElgeqiDNLQRVKQKLEKEKS---EYKM 1228
Cdd:TIGR01612  830 IFKIINEMKFMKddflNKVDKFINFENNCKEKIDSEHEQFAELTNKIKAEISD-----DKLNDYEKKFNDSKSlinEINK 904
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1229 EIDDLSSNMEAVAKAKANLeKMCRTLEDQLSEIKSKNDenlrQINDLSAQRARLQTENGEFGRQLEEK--EALVSQLTRG 1306
Cdd:TIGR01612  905 SIEEEYQNINTLKKVDEYI-KICENTKESIEKFHNKQN----ILKEILNKNIDTIKESNLIEKSYKDKfdNTLIDKINEL 979
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1307 KQAFTQ-QIEELKRQIEEEVKAKNALAHAVQSARHdcDLLREQFEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRT 1385
Cdd:TIGR01612  980 DKAFKDaSLNDYEAKNNELIKYFNDLKANLGKNKE--NMLYHQFDEKEKATNDIEQKIEDANKNIPNIEIAIHTSIYNII 1057
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1386 EELEESKKKLAQRLQeaEEQIEAVNSKCASLEKTKQRLQG-EVEDLmidVERANALAANLDKKQRNFDKVLaewKQKYEE 1464
Cdd:TIGR01612 1058 DEIEKEIGKNIELLN--KEILEEAEINITNFNEIKEKLKHyNFDDF---GKEENIKYADEINKIKDDIKNL---DQKIDH 1129
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1465 GQAELEGAQKEARSLSTELFKMKNSYEETLDQleTLKREN-KNLQQEISDLTEQLgETGKSIHElekSKKAVETEKAEI- 1542
Cdd:TIGR01612 1130 HIKALEEIKKKSENYIDEIKAQINDLEDVADK--AISNDDpEEIEKKIENIVTKI-DKKKNIYD---EIKKLLNEIAEIe 1203
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1543 --QTALEEAEG-TLEHEES--KILRVQLELNQVKSEIDRKLAEKD-EEIEQIKRNSQRITDSMQSTLD--SEVRSRN--- 1611
Cdd:TIGR01612 1204 kdKTSLEEVKGiNLSYGKNlgKLFLEKIDEEKKKSEHMIKAMEAYiEDLDEIKEKSPEIENEMGIEMDikAEMETFNish 1283
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1612 ----DALRIKKKME---GDLNEMEIQLSHANRQAAEAQKQLRNVQAQLKDAQLHLDDAVRGQEDMKEQVAMVERRNtlMQ 1684
Cdd:TIGR01612 1284 dddkDHHIISKKHDeniSDIREKSLKIIEDFSEESDINDIKKELQKNLLDAQKHNSDINLYLNEIANIYNILKLNK--IK 1361
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1685 SEIEELRAALEQTERGRKVAEQELvDASERVGLLHSQNTSLLNTKKKLEADLvqiqsEVEDTVQEARNAEDKAKKAITDA 1764
Cdd:TIGR01612 1362 KIIDEVKEYTKEIEENNKNIKDEL-DKSEKLIKKIKDDINLEECKSKIESTL-----DDKDIDECIKKIKELKNHILSEE 1435
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1765 AMMAEELKKEQDTSAHLERMKKNLEVTVKDLQHRLDEAENLA---MKGGKKQLQKLESRVRELESEVEAEQRRGADAVKG 1841
Cdd:TIGR01612 1436 SNIDTYFKNADENNENVLLLFKNIEMADNKSQHILKIKKDNAtndHDFNINELKEHIDKSKGCKDEADKNAKAIEKNKEL 1515
                         1050      1060      1070      1080      1090      1100
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 288856329  1842 VRKYERRVKEL--TYQTEEDKKNVNRLQDLVDKLQLKVKAYKRQSEEAEEQANSHLSKLRKVQHELEE 1907
Cdd:TIGR01612 1516 FEQYKKDVTELlnKYSALAIKNKFAKTKKDSEIIIKEIKDAHKKFILEAEKSEQKIKEIKKEKFRIED 1583
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
1106-1818 6.23e-06

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 51.36  E-value: 6.23e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1106 LQKKIKELQARIEE-LEEEIEAERAARAKVEKQRADLSRELE-EISERLEEAGGATAAQIEMNKKREaEFQKLRRDLEEs 1183
Cdd:pfam10174    1 LQAQLRDLQRENELlRRELDIKESKLGSSMNSIKTFWSPELKkERALRKEEAARISVLKEQYRVTQE-ENQHLQLTIQA- 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1184 tLQHEATAaalrkkQADSVAELGEQIDNLQRVKQKLEKEKSEYKMEIDDLSSNMEAVAKakaNLEKMCRTLEDQLSEIKS 1263
Cdd:pfam10174   79 -LQDELRA------QRDLNQLLQQDFTTSPVDGEDKFSTPELTEENFRRLQSEHERQAK---ELFLLRKTLEEMELRIET 148
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1264 KN------DENLRQINDL---SAQRARLQTENGEFGRQLEEKEALVSQLtrgkQAFTQQIEELKRQIEEEVKAKNALAHA 1334
Cdd:pfam10174  149 QKqtlgarDESIKKLLEMlqsKGLPKKSGEEDWERTRRIAEAEMQLGHL----EVLLDQKEKENIHLREELHRRNQLQPD 224
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1335 VQSARhdcdLLREQFEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEE-------SK------KKLAQRLQE 1401
Cdd:pfam10174  225 PAKTK----ALQTVIEMKDTKISSLERNIRDLEDEVQMLKTNGLLHTEDREEEIKQmevykshSKfmknkiDQLKQELSK 300
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1402 AEEQIEAVNSKCASLEK----TKQRLQGEVEDLMIDVERAN-------ALAANLDKKQRNFDKvlaewKQKYeegqaeLE 1470
Cdd:pfam10174  301 KESELLALQTKLETLTNqnsdCKQHIEVLKESLTAKEQRAAilqtevdALRLRLEEKESFLNK-----KTKQ------LQ 369
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1471 GAQKEARSLSTELFKMKnsyeetlDQLETLKRENKNLQQEISDLTEQLGETGKSIHELEKSKKAVETEKAEIQTALEEAE 1550
Cdd:pfam10174  370 DLTEEKSTLAGEIRDLK-------DMLDVKERKINVLQKKIENLQEQLRDKDKQLAGLKERVKSLQTDSSNTDTALTTLE 442
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1551 GTLEHEESKILRvqlelnqVKSEIDRKLAEKDEEIEQIKRNSQ-----------RITDSMQSTLDSEVRSRNDALRIKKK 1619
Cdd:pfam10174  443 EALSEKERIIER-------LKEQREREDRERLEELESLKKENKdlkekvsalqpELTEKESSLIDLKEHASSLASSGLKK 515
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1620 mEGDLNEMEIQLSHANRQAAEAQKQLRNVQaqlkdaqlHLDDAVRGQEDMKEQVAMVERRNTLM-------QSEIEELRA 1692
Cdd:pfam10174  516 -DSKLKSLEIAVEQKKEECSKLENQLKKAH--------NAEEAVRTNPEINDRIRLLEQEVARYkeesgkaQAEVERLLG 586
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1693 ALEQTERGRKVAEQELVDASERVGLLH-SQNTSLLNTKKKLEADLVQIQSEVEDTVQEARNAEDKAKKAITDAAMMAEEL 1771
Cdd:pfam10174  587 ILREVENEKNDKDKKIAELESLTLRQMkEQNKKVANIKHGQQEMKKKGAQLLEEARRREDNLADNSQQLQLEELMGALEK 666
                          730       740       750       760
                   ....*....|....*....|....*....|....*....|....*..
gi 288856329  1772 KKEQdtsahLERMKKNLEVTVKDLQHRLDEAENLAMKGGKKQLQKLE 1818
Cdd:pfam10174  667 TRQE-----LDATKARLSSTQQSLAEKDGHLTNLRAERRKQLEEILE 708
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
1344-1763 6.34e-06

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 51.05  E-value: 6.34e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1344 LLREQFEEEQEAKAELQRGMSKANSEVAQWRTKYETDaiqrTEELEESKKKLAQRLQEAEEQIeavnskcaslektkQRL 1423
Cdd:pfam07888   31 LLQNRLEECLQERAELLQAQEAANRQREKEKERYKRD----REQWERQRRELESRVAELKEEL--------------RQS 92
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1424 QGEVEDLMIDVERANALAANLDKKQRNFDKVLAEWKQKYEEGQAELEGAQKEARSLSTELFKMKNSYEETLDQLETLKRE 1503
Cdd:pfam07888   93 REKHEELEEKYKELSASSEELSEEKDALLAQRAAHEARIRELEEDIKTLTQRVLERETELERMKERAKKAGAQRKEEEAE 172
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1504 NKNLQQEIsdlteqlgetgksihelekskKAVETEKAEIQTALEEAEGTLEHEESKILRVQLELNQVKSEID---RKLAE 1580
Cdd:pfam07888  173 RKQLQAKL---------------------QQTEEELRSLSKEFQELRNSLAQRDTQVLQLQDTITTLTQKLTtahRKEAE 231
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1581 KDEEIEQIKRNSQRITDSMQST--LDSEVRSrndALRIKKKMEGDLNEMEIQLSHANRQAAEAQKQLRNVQAQL-KDAQL 1657
Cdd:pfam07888  232 NEALLEELRSLQERLNASERKVegLGEELSS---MAAQRDRTQAELHQARLQAAQLTLQLADASLALREGRARWaQERET 308
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1658 HLDDAVRGQEDMKEQVAMVERRNTLMQSEIEElRAALEqTERGRKvAEQELVDASERVGLLHSQNTSLLNTKKKLEadlv 1737
Cdd:pfam07888  309 LQQSAEADKDRIEKLSAELQRLEERLQEERME-REKLE-VELGRE-KDCNRVQLSESRRELQELKASLRVAQKEKE---- 381
                          410       420
                   ....*....|....*....|....*.
gi 288856329  1738 QIQSEVEDTVQEARNAEDKAKKAITD 1763
Cdd:pfam07888  382 QLQAEKQELLEYIRQLEQRLETVADA 407
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
936-1233 1.06e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 50.68  E-value: 1.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  936 AELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAtENKVKNLTEE---MAAQDESIGKLTKEKKALQEAHQQtLDDL 1012
Cdd:COG4913   613 AALEAELAELEEELAEAEERLEALEAELDALQERREA-LQRLAEYSWDeidVASAEREIAELEAELERLDASSDD-LAAL 690
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1013 QAEEDKvntltksktkLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDLENDKQQSEEKLKKKDFETsql 1092
Cdd:COG4913   691 EEQLEE----------LEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALLEERFAA--- 757
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1093 LSKIEDEQSLGAQLQKKIKELQarieeleeeieaeraarAKVEKQRADLSRELEEISERLEEAGGATAAQIEmnkkREAE 1172
Cdd:COG4913   758 ALGDAVERELRENLEERIDALR-----------------ARLNRAEEELERAMRAFNREWPAETADLDADLE----SLPE 816
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 288856329 1173 FQKLRRDLEESTL-QHEATAAALRKKQAdsvaelGEQIDNLQrvkQKLEKEKSEYKMEIDDL 1233
Cdd:COG4913   817 YLALLDRLEEDGLpEYEERFKELLNENS------IEFVADLL---SKLRRAIREIKERIDPL 869
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1675-1920 1.06e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 50.68  E-value: 1.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1675 MVERRNTLmqSEIEELRAALEQTERgrkvAEQELVDASERVGLLhsqntsllntkkkleADLVQIQSEVEDTVQEARNAE 1754
Cdd:COG4913   217 MLEEPDTF--EAADALVEHFDDLER----AHEALEDAREQIELL---------------EPIRELAERYAAARERLAELE 275
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1755 D-----KAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEVTVKDLQHRLDEAENLAMKGGKKQLQklesrvrELESEVE 1829
Cdd:COG4913   276 YlraalRLWFAQRRLELLEAELEELRAELARLEAELERLEARLDALREELDELEAQIRGNGGDRLE-------QLEREIE 348
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1830 AEQRRGADAVKGVRKYERRVKELTYQTEEDKKNVNRLQDLVDKLqlkVKAYKRQSEEAEEQANSHLSKLRKVQHELEEAE 1909
Cdd:COG4913   349 RLERELEERERRRARLEALLAALGLPLPASAEEFAALRAEAAAL---LEALEEELEALEEALAEAEAALRDLRRELRELE 425
                         250
                  ....*....|..
gi 288856329 1910 -ERADIAESQVN 1920
Cdd:COG4913   426 aEIASLERRKSN 437
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
1351-1632 1.44e-05

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 49.96  E-value: 1.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1351 EEQEAKAELQRGMSKANSEVAQWRTKYETDAI----QRTEELEESKKKLAQRLQEAEEQIEavnskcaslEKTKQRLQGE 1426
Cdd:COG5185   239 QDPESELEDLAQTSDKLEKLVEQNTDLRLEKLgenaESSKRLNENANNLIKQFENTKEKIA---------EYTKSIDIKK 309
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1427 VEDLMIDVERANALAANLDKKQRNFDKVLAEWKQKYEEGQAELEGAQKEARSLSTELFKMKNS------YEETLDQLETL 1500
Cdd:COG5185   310 ATESLEEQLAAAEAEQELEESKRETETGIQNLTAEIEQGQESLTENLEAIKEEIENIVGEVELsksseeLDSFKDTIEST 389
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1501 KRENKNLQQEISDLTEQLGETgksiheLEKSKKAVETEKAEIQTALEEAEGTLEHEESKILRVQLELNQVKSEIDRKLAE 1580
Cdd:COG5185   390 KESLDEIPQNQRGYAQEILAT------LEDTLKAADRQIEELQRQIEQATSSNEEVSKLLNELISELNKVMREADEESQS 463
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 288856329 1581 KDEEIEQIKRNSQRitdSMQSTLDSEVRSRNDALR-IKKKMEGDLNEMEIQLS 1632
Cdd:COG5185   464 RLEEAYDEINRSVR---SKKEDLNEELTQIESRVStLKATLEKLRAKLERQLE 513
mukB PRK04863
chromosome partition protein MukB;
1554-1926 1.46e-05

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 50.34  E-value: 1.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1554 EHEESKILRVQLELNQVKSEIDRKLAEKDE-------EIEQIKRNSQRITDSMQSTLDSEVRSRNdALRIKKKME---GD 1623
Cdd:PRK04863  278 ANERRVHLEEALELRRELYTSRRQLAAEQYrlvemarELAELNEAESDLEQDYQAASDHLNLVQT-ALRQQEKIEryqAD 356
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1624 LNEMEIQLSHANRQAAEAQkqlrnvqaqlkdaqlhlddavrgqedmkEQVAMVERRNTLMQSEIEELRAALEQTergrkv 1703
Cdd:PRK04863  357 LEELEERLEEQNEVVEEAD----------------------------EQQEENEARAEAAEEEVDELKSQLADY------ 402
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1704 aeQELVDASERVGLLHSQNTSLLNTKKKLEADLVQIQSEVEDTVQEARNAEdkakKAITDAAMMAEElkKEQDTSAHLER 1783
Cdd:PRK04863  403 --QQALDVQQTRAIQYQQAVQALERAKQLCGLPDLTADNAEDWLEEFQAKE----QEATEELLSLEQ--KLSVAQAAHSQ 474
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1784 MKKNLEV---------------TVKDLQHRLDEAENLAmkggkKQLQKLESRVRELESEVEAEQRrgadAVKGVRKYERR 1848
Cdd:PRK04863  475 FEQAYQLvrkiagevsrseawdVARELLRRLREQRHLA-----EQLQQLRMRLSELEQRLRQQQR----AERLLAEFCKR 545
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1849 VkELTYQTEEDkknvnrLQDLVDKLQLKVKAYKRQSEEAEEQANSHLSKLRKVQHELEEAEERADI---AESQVNKLRAK 1925
Cdd:PRK04863  546 L-GKNLDDEDE------LEQLQEELEARLESLSESVSEARERRMALRQQLEQLQARIQRLAARAPAwlaAQDALARLREQ 618

                  .
gi 288856329 1926 S 1926
Cdd:PRK04863  619 S 619
Crescentin pfam19220
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament ...
917-1341 1.69e-05

Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteriztic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.


Pssm-ID: 437057 [Multi-domain]  Cd Length: 401  Bit Score: 49.30  E-value: 1.69e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   917 LEAKLKETTERLEDEEEINAELTAKKRKLEDECSEL---KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAAQDESIGK 993
Cdd:pfam19220    8 LRVRLGEMADRLEDLRSLKADFSQLIEPIEAILRELpqaKSRLLELEALLAQERAAYGKLRRELAGLTRRLSAAEGELEE 87
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   994 LTKEKKALQEAHQQTldDLQAEEDKVNTLTKsktklEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDLEN 1073
Cdd:pfam19220   88 LVARLAKLEAALREA--EAAKEELRIELRDK-----TAQAEALERQLAAETEQNRALEEENKALREEAQAAEKALQRAEG 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1074 DKQQSEEKLKKKDFETSQLLSKIEDEQSLGAQLQKKIKELqarieeleeeieaeraarakvEKQRADLSRELEEISERLE 1153
Cdd:pfam19220  161 ELATARERLALLEQENRRLQALSEEQAAELAELTRRLAEL---------------------ETQLDATRARLRALEGQLA 219
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1154 EAggataaqiemnkkrEAEFQKLRRDLEE--STLQHEATAAALRKKQADSVAELGEQIDNLQRVKQKlekekseykmeid 1231
Cdd:pfam19220  220 AE--------------QAERERAEAQLEEavEAHRAERASLRMKLEALTARAAATEQLLAEARNQLR------------- 272
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1232 DLSSNMEAVAKAKANLEKMCRTLEDQLSEIKSKNDENLRQINDLSAQRARLQTENGEFGRQLEEKEAL------------ 1299
Cdd:pfam19220  273 DRDEAIRAAERRLKEASIERDTLERRLAGLEADLERRTQQFQEMQRARAELEERAEMLTKALAAKDAAleraeeriasls 352
                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*....
gi 288856329  1300 --VSQLTR----GKQAFTQQIEELKRQIEEEvKAKNALAH-AVQSARHD 1341
Cdd:pfam19220  353 drIAELTKrfevERAALEQANRRLKEELQRE-RAERALAQgALEIARES 400
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
1481-1674 1.73e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 49.44  E-value: 1.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1481 TELFKMKNSYEETLDQLETLKRENKNLQQEISDLTEQLGETGKSIHELEKSKKAVETEKAEIQTALEEAEGTLEheesKI 1560
Cdd:COG3883    16 PQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELG----ER 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1561 LRVQLELNQVKSEIDRKLAEKD--------EEIEQIKRNSQRITDSMQSTLDSEVRSRNDALRIKKKMEGDLNEMEIQLS 1632
Cdd:COG3883    92 ARALYRSGGSVSYLDVLLGSESfsdfldrlSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKA 171
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 288856329 1633 HANRQAAEAQKQLRNVQAQLKDAQLHLDDAVRGQEDMKEQVA 1674
Cdd:COG3883   172 ELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAA 213
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
1452-1644 1.78e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 49.44  E-value: 1.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1452 DKVLAEWKQKYEEGQAELEGAQKEARSLSTELFKMKNSYEETLDQLETLKRENKNLQQEISD-------LTEQLGETGKS 1524
Cdd:COG3883    15 DPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEaeaeieeRREELGERARA 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1525 -----------------------IHELEKSKKAVETEKAEI------QTALEEAEGTLEHEESKILRVQLELNQVKSEID 1575
Cdd:COG3883    95 lyrsggsvsyldvllgsesfsdfLDRLSALSKIADADADLLeelkadKAELEAKKAELEAKLAELEALKAELEAAKAELE 174
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 288856329 1576 RKLAEKDEEIEQIKRNSQRITDSMQStLDSEVRSRNDALRIKKKMEGDLNEMEIQLSHANRQAAEAQKQ 1644
Cdd:COG3883   175 AQQAEQEALLAQLSAEEAAAEAQLAE-LEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 242
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1755-1928 2.00e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 49.77  E-value: 2.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1755 DKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEVTVKDLQHRLDEAENLamkggkKQLQKLESRVRELESEVEAEQRR 1834
Cdd:COG4717    74 KELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKL------LQLLPLYQELEALEAELAELPER 147
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1835 GADAVKGVRKYERRVKELTYQTEEDKKNVNRLQDLVDKLQLkvkAYKRQSEEAEEQANSHLSKLRKVQHELEEAEERADI 1914
Cdd:COG4717   148 LEELEERLEELRELEEELEELEAELAELQEELEELLEQLSL---ATEEELQDLAEELEELQQRLAELEEELEEAQEELEE 224
                         170
                  ....*....|....
gi 288856329 1915 AESQVNKLRAKSRD 1928
Cdd:COG4717   225 LEEELEQLENELEA 238
PRK01156 PRK01156
chromosome segregation protein; Provisional
911-1349 2.05e-05

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 49.90  E-value: 2.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  911 IKSKIQleaKLKETTERLEDEEEINAELTAKKRKLED---ECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAAQ 987
Cdd:PRK01156  317 IDAEIN---KYHAIIKKLSVLQKDYNDYIKKKSRYDDlnnQILELEGYEMDYNSYLKSIESLKKKIEEYSKNIERMSAFI 393
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  988 DESIGKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKSKTKLEQQVDDLEGSL------------------EQEKKLRMD 1049
Cdd:PRK01156  394 SEILKIQEIDPDAIKKELNEINVKLQDISSKVSSLNQRIRALRENLDELSRNMemlngqsvcpvcgttlgeEKSNHIINH 473
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1050 LERAKRKLEGDLKLAQESIMDLENDKQQseeKLKKKDFETSQLLSKIEDEQSLGAQLQKKIKELQARIEELEEEIEAERA 1129
Cdd:PRK01156  474 YNEKKSRLEEKIREIEIEVKDIDEKIVD---LKKRKEYLESEEINKSINEYNKIESARADLEDIKIKINELKDKHDKYEE 550
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1130 ARAKVEkqradlSRELEEISERLEEAGGATAA----QIEMNKKREAEFQKLRRDLEESTLQHEATAAALRKKQADSVAEL 1205
Cdd:PRK01156  551 IKNRYK------SLKLEDLDSKRTSWLNALAVisliDIETNRSRSNEIKKQLNDLESRLQEIEIGFPDDKSYIDKSIREI 624
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1206 GEQIDNLQRVKQKLEkeksEYKMEIDDLSSNMEAVAKAKANLEkmcrTLEDQLSEIKSKndenLRQIND-LSAQRARLQT 1284
Cdd:PRK01156  625 ENEANNLNNKYNEIQ----ENKILIEKLRGKIDNYKKQIAEID----SIIPDLKEITSR----INDIEDnLKKSRKALDD 692
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 288856329 1285 ENGEfgrqLEEKEALVSQLTRGKQAFTQQIEELKRQIEEEVKAKNALAhavqsarhDCDLLREQF 1349
Cdd:PRK01156  693 AKAN----RARLESTIEILRTRINELSDRINDINETLESMKKIKKAIG--------DLKRLREAF 745
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1193-1449 2.07e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 49.63  E-value: 2.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1193 ALRKKQADSVAE-LGEQIDNLQRVKQKLEKEKSEYKMEIDDLSSNMEAvakakanlekmcRTLEDQLSEIKSkndenlrQ 1271
Cdd:COG3206   167 ELRREEARKALEfLEEQLPELRKELEEAEAALEEFRQKNGLVDLSEEA------------KLLLQQLSELES-------Q 227
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1272 INDLSAQRARLQTENGEFGRQLEEKEALVSQLTR--GKQAFTQQIEELKRQIEEEVKAKNALAHAVQSarhdcdlLREQF 1349
Cdd:COG3206   228 LAEARAELAEAEARLAALRAQLGSGPDALPELLQspVIQQLRAQLAELEAELAELSARYTPNHPDVIA-------LRAQI 300
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1350 EE-EQEAKAELQRGMSKANSEVAQwrtkyetdaiqrteeleeskkkLAQRLQEAEEQIEAVNSKCASLektkQRLQGEVE 1428
Cdd:COG3206   301 AAlRAQLQQEAQRILASLEAELEA----------------------LQAREASLQAQLAQLEARLAEL----PELEAELR 354
                         250       260
                  ....*....|....*....|.
gi 288856329 1429 DLMIDVERANALAANLDKKQR 1449
Cdd:COG3206   355 RLEREVEVARELYESLLQRLE 375
PRK12704 PRK12704
phosphodiesterase; Provisional
1327-1470 2.40e-05

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 49.01  E-value: 2.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1327 AKNALAHAVQSARHDCDLLREqfEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEESKKKLAQRlqeaEEQi 1406
Cdd:PRK12704   25 RKKIAEAKIKEAEEEAKRILE--EAKKEAEAIKKEALLEAKEEIHKLRNEFEKELRERRNELQKLEKRLLQK----EEN- 97
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 288856329 1407 eaVNSKCASLEKTKQRLQGEVEdlmidveranalaaNLDKKQRNFDKVLAEWKQKYEEGQAELE 1470
Cdd:PRK12704   98 --LDRKLELLEKREEELEKKEK--------------ELEQKQQELEKKEEELEELIEEQLQELE 145
EzrA pfam06160
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...
1486-1922 2.48e-05

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.


Pssm-ID: 428797 [Multi-domain]  Cd Length: 542  Bit Score: 49.08  E-value: 2.48e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1486 MKNSYEETLDQLETLKRE--NKNLQQEISDLtEQLGETGKSIHELEKSKK----AVETEKAEIQTALEEAEGTLE----H 1555
Cdd:pfam06160    4 LRKKIYKEIDELEERKNElmNLPVQEELSKV-KKLNLTGETQEKFEEWRKkwddIVTKSLPDIEELLFEAEELNDkyrfK 82
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1556 EESKILR-VQLELNQVKSEIDRKLAEKDEEIEQIKRNSQRITDSMQS--TLDSEVRSRNDAL-RIKKKMEGDLNEMEIQL 1631
Cdd:pfam06160   83 KAKKALDeIEELLDDIEEDIKQILEELDELLESEEKNREEVEELKDKyrELRKTLLANRFSYgPAIDELEKQLAEIEEEF 162
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1632 SH-----ANRQAAEAQKQLRNVQAQLKDAQlhlddavrgqEDMKEQVAMVERRNTLMQSEIEELRAALEQ-TERGRKVA- 1704
Cdd:pfam06160  163 SQfeeltESGDYLEAREVLEKLEEETDALE----------ELMEDIPPLYEELKTELPDQLEELKEGYREmEEEGYALEh 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1705 ---EQELVDASERVgllhSQNTSLLNTK--KKLEADLVQIQSEVeDTVQEARNAEDKAKKaitdaammaeELKKEQDT-S 1778
Cdd:pfam06160  233 lnvDKEIQQLEEQL----EENLALLENLelDEAEEALEEIEERI-DQLYDLLEKEVDAKK----------YVEKNLPEiE 297
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1779 AHLERMKKNLEVTVKDLQH-----RLDEAENLAMKGGKKQLQKLESRVRELE------------------------SEVE 1829
Cdd:pfam06160  298 DYLEHAEEQNKELKEELERvqqsyTLNENELERVRGLEKQLEELEKRYDEIVerleekevayselqeeleeileqlEEIE 377
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1830 AEQRRGADAVKGVRKYERRVKELTYQTEEDKKNVNRlqdLVDKLQL-----KVKAYKRQSEEAEEQANSHLSKLR----K 1900
Cdd:pfam06160  378 EEQEEFKESLQSLRKDELEAREKLDEFKLELREIKR---LVEKSNLpglpeSYLDYFFDVSDEIEDLADELNEVPlnmdE 454
                          490       500
                   ....*....|....*....|..
gi 288856329  1901 VQHELEEAEERADIAESQVNKL 1922
Cdd:pfam06160  455 VNRLLDEAQDDVDTLYEKTEEL 476
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
882-1083 2.57e-05

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 49.25  E-value: 2.57e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   882 LLQEKNDLQLAVASESENLSDAEERCEGLIKSKIQLEAKLKETTERLEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 961
Cdd:TIGR04523  445 LTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKE 524
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   962 TLAKVEKEKHATENKVK----------------NLTEEMAAQDESIGKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKS 1025
Cdd:TIGR04523  525 KIEKLESEKKEKESKISdledelnkddfelkkeNLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKE 604
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 288856329  1026 KTKLEQQVDDLEGSLEQEKK-------LRMDLERAKRKLEGDLKLAQESIMDLENDKQQSEEKLK 1083
Cdd:TIGR04523  605 IEEKEKKISSLEKELEKAKKeneklssIIKNIKSKKNKLKQEVKQIKETIKEIRNKWPEIIKKIK 669
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
1621-1930 2.99e-05

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 49.40  E-value: 2.99e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1621 EGDLNEMEIQLSHANRQAAEAQKQLRNVQaqLKDAQLhlddavrgqEDMKEQVAMVERRNTLMQSEIEELRAALEQTerg 1700
Cdd:pfam01576    4 EEEMQAKEEELQKVKERQQKAESELKELE--KKHQQL---------CEEKNALQEQLQAETELCAEAEEMRARLAAR--- 69
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1701 RKVAEQELVDASERVGLLHSQNTSLLNTKKKLEADLVQIQSEVEDtvQEARNAEDKAKKAITDAAM--MAEELKKEQDTS 1778
Cdd:pfam01576   70 KQELEEILHELESRLEEEEERSQQLQNEKKKMQQHIQDLEEQLDE--EEAARQKLQLEKVTTEAKIkkLEEDILLLEDQN 147
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1779 AHLERMKKNLEVTVKDLQHRLDEAENLAmKGGKKQLQKLESRVRELESEVEAEQRRGADAVKGVRKYERRVKELTYQTEE 1858
Cdd:pfam01576  148 SKLSKERKLLEERISEFTSNLAEEEEKA-KSLSKLKNKHEAMISDLEERLKKEEKGRQELEKAKRKLEGESTDLQEQIAE 226
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 288856329  1859 DKKNVNRLQDLVDKLQLKVKAYKRQSEEAEEQANSHLSKLRKVQHELEEAEERADIAESQVNKLRAKSRDSG 1930
Cdd:pfam01576  227 LQAQIAELRAQLAKKEEELQAALARLEEETAQKNNALKKIRELEAQISELQEDLESERAARNKAEKQRRDLG 298
CCCAP pfam15964
Centrosomal colon cancer autoantigen protein family; CCCAP is a family of proteins found in ...
1418-1759 3.50e-05

Centrosomal colon cancer autoantigen protein family; CCCAP is a family of proteins found in eukaryotes. CCCAP is also known as SDCCAG8, serologically defined colon cancer antigen 8. It is associated with the centrosome.


Pssm-ID: 435040 [Multi-domain]  Cd Length: 703  Bit Score: 48.75  E-value: 3.50e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1418 KTKQRLQGEVEDLMIDVERANALAANLDKKQRNFDKVLAEWKQKYEEGQAELEGAQKEARSLSTELFKMKNSYEETLD-Q 1496
Cdd:pfam15964  300 QTIERLTKERDDLMSALVSVRSSLAEAQQRESSAYEQVKQAVQMTEEANFEKTKALIQCEQLKSELERQKERLEKELAsQ 379
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1497 LETLKRENKNLQQEISDLTEQLGET----GKSIHELEKSKKAVETEKAEIQTALEEAEGTLEHEESKILRVQLELNQVKS 1572
Cdd:pfam15964  380 QEKRAQEKEALRKEMKKEREELGATmlalSQNVAQLEAQVEKVTREKNSLVSQLEEAQKQLASQEMDVTKVCGEMRYQLN 459
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1573 EIDRKLAEKDEEIEQIKRNSQRITDsmqsTLDSEVrsrndalrikKKMEGDLNEMEIQLSHANRQAAEAQKQLRNVQAQL 1652
Cdd:pfam15964  460 QTKMKKDEAEKEHREYRTKTGRQLE----IKDQEI----------EKLGLELSESKQRLEQAQQDAARAREECLKLTELL 525
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1653 KDA--QLHLDDAVRGQ------EDMKEQVAMVERRNTLMQSEIEELRAALEQTERgrkvaeqelvdasERVGLLHSQNTS 1724
Cdd:pfam15964  526 GESehQLHLTRLEKESiqqsfsNEAKAQALQAQQREQELTQKMQQMEAQHDKTVN-------------EQYSLLTSQNTF 592
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|..
gi 288856329  1725 LLNTK-------KKLEADLVQIQSEVEDTVQEARNAEDKAKK 1759
Cdd:pfam15964  593 IAKLKeecctlaKKLEEITQKSRSEVEQLSQEKEYLQDRLEK 634
PLN02939 PLN02939
transferase, transferring glycosyl groups
882-1113 3.63e-05

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 49.13  E-value: 3.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  882 LLQEKNDLQLAVASESENLSDAEERCEGLIKSKI-------QLEAKLKETTERLEDEEEINAELTAKKRKLEDECSELKK 954
Cdd:PLN02939  161 ILTEKEALQGKINILEMRLSETDARIKLAAQEKIhveileeQLEKLRNELLIRGATEGLCVHSLSKELDVLKEENMLLKD 240
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  955 DIDDLELTLAKVEKekhaTENKVKNLTEEMAAQDESIGKLTKEKKALQEAHQQtLDDLQAEE--DKVNTLTKSKTKLEQQ 1032
Cdd:PLN02939  241 DIQFLKAELIEVAE----TEERVFKLEKERSLLDASLRELESKFIVAQEDVSK-LSPLQYDCwwEKVENLQDLLDRATNQ 315
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1033 VDDLEGSLEQEKKLRMDLErakrKLEGDLKLAQES-----IMDLENDKQQS-EEKLKKKDFETsqlLSKIEDEQSLGAQL 1106
Cdd:PLN02939  316 VEKAALVLDQNQDLRDKVD----KLEASLKEANVSkfssyKVELLQQKLKLlEERLQASDHEI---HSYIQLYQESIKEF 388

                  ....*..
gi 288856329 1107 QKKIKEL 1113
Cdd:PLN02939  389 QDTLSKL 395
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1346-1565 3.72e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 48.86  E-value: 3.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1346 REQFEEE-QEAKAELQrgmsKANSEVAQWRTKYE-TDAIQRTEELEESKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRL 1423
Cdd:COG3206   177 LEFLEEQlPELRKELE----EAEAALEEFRQKNGlVDLSEEAKLLLQQLSELESQLAEARAELAEAEARLAALRAQLGSG 252
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1424 QGEVEDLMidverANALAANLDKKQRNFDKVLAEWKQKYEEGQAELEGAQKEARSLSTELFKMKNSYEETLD-QLETLKR 1502
Cdd:COG3206   253 PDALPELL-----QSPVIQQLRAQLAELEAELAELSARYTPNHPDVIALRAQIAALRAQLQQEAQRILASLEaELEALQA 327
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 288856329 1503 ENKNLQQEISDLTEQLGETGKSIHELEKSKKAVETEKAEIQTALEEAEGTLEHEESKILRVQL 1565
Cdd:COG3206   328 REASLQAQLAQLEARLAELPELEAELRRLEREVEVARELYESLLQRLEEARLAEALTVGNVRV 390
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
846-1114 5.25e-05

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 48.48  E-value: 5.25e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   846 ETEKELATMKEDFVKCKEDLAKAEAKKKELEEKMVALLQEKNDLQLAVASESENLSDAEERCEGLIKSKIQLEAKLKETT 925
Cdd:TIGR04523  367 EKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLT 446
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   926 ERLEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAAQDESIGKLTKEKKALQEah 1005
Cdd:TIGR04523  447 NQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKE-- 524
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1006 qqtlddlqaeedKVNTLTKSKTKLEQQVDDLEGSLEQEK--KLRMDLERAKRKLEGDLKLAQESIMDLENDKQQSEEKLK 1083
Cdd:TIGR04523  525 ------------KIEKLESEKKEKESKISDLEDELNKDDfeLKKENLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELID 592
                          250       260       270
                   ....*....|....*....|....*....|.
gi 288856329  1084 KKDFETSQLLSKIEDEQSLGAQLQKKIKELQ 1114
Cdd:TIGR04523  593 QKEKEKKDLIKEIEEKEKKISSLEKELEKAK 623
PRK11281 PRK11281
mechanosensitive channel MscK;
1463-1738 5.69e-05

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 48.37  E-value: 5.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1463 EEGQAELEGAQKeARSLSTELFKMKNSYEETLDQL---ETLKRENKNLQQEISDLTEQLGETGKsihELEKSKKAVETEK 1539
Cdd:PRK11281   39 ADVQAQLDALNK-QKLLEAEDKLVQQDLEQTLALLdkiDRQKEETEQLKQQLAQAPAKLRQAQA---ELEALKDDNDEET 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1540 AEI--QTALEEAEGTLEHEESKILRVQLELNQVKSEI-------DRKLAEKDEEIEQIkrnsQRITDSMQSTLDSEVRSR 1610
Cdd:PRK11281  115 RETlsTLSLRQLESRLAQTLDQLQNAQNDLAEYNSQLvslqtqpERAQAALYANSQRL----QQIRNLLKGGKVGGKALR 190
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1611 NDAlriKKKMEGDLNEMEIQLSHaNRQAAEAQKQLRNV-QAQlkdaqlhlddavrgQEDMKEQVAMVERRNTLMQSEIEE 1689
Cdd:PRK11281  191 PSQ---RVLLQAEQALLNAQNDL-QRKSLEGNTQLQDLlQKQ--------------RDYLTARIQRLEHQLQLLQEAINS 252
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 288856329 1690 LRaaLEQTErgRKVAEQELVDASERVG---LLHSQntslLNTKKKLEADLVQ 1738
Cdd:PRK11281  253 KR--LTLSE--KTVQEAQSQDEAARIQanpLVAQE----LEINLQLSQRLLK 296
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
1200-1504 5.97e-05

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 47.21  E-value: 5.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1200 DSVAELGEQIDNLQRVKQKLEKEKSEYKMEIDDLSSNMEAVAKAKANLEKMCRTLEDQLSEIKSKNDENLRQINDLSAQR 1279
Cdd:COG1340     1 SKTDELSSSLEELEEKIEELREEIEELKEKRDELNEELKELAEKRDELNAQVKELREEAQELREKRDELNEKVKELKEER 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1280 ARLQTENGEFGRQLEEKEALVSQLTRGKqaftQQIEELKRQIEEEVKaknalahAVQSARHDCDLLREQFEE--EQEAKA 1357
Cdd:COG1340    81 DELNEKLNELREELDELRKELAELNKAG----GSIDKLRKEIERLEW-------RQQTEVLSPEEEKELVEKikELEKEL 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1358 ELQRGMSKANSEVAQWRTKYETDAIQRtEELEESKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQGEVEDLMIDVERA 1437
Cdd:COG1340   150 EKAKKALEKNEKLKELRAELKELRKEA-EEIHKKIKELAEEAQELHEEMIELYKEADELRKEADELHKEIVEAQEKADEL 228
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 288856329 1438 NALAANLDKKQRNFDKVLAEWKQKYEEgqAELEGAQKEARSLSTELF-KMKNSYEETLDQLETLKREN 1504
Cdd:COG1340   229 HEEIIELQKELRELRKELKKLRKKQRA--LKREKEKEELEEKAEEIFeKLKKGEKLTTEELKLLQKSG 294
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1566-1788 6.01e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 47.45  E-value: 6.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1566 ELNQVKSEIDRKLAEKDEEIEQIKRNSQRITDSMQStLDSEVRSRNDALRikkKMEGDLNEMEIQLSHANRQAAEAQKQL 1645
Cdd:COG4942    24 EAEAELEQLQQEIAELEKELAALKKEEKALLKQLAA-LERRIAALARRIR---ALEQELAALEAELAELEKEIAELRAEL 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1646 RNVQAQLKD------------------AQLHLDDAVRGQEDMKeqvAMVERRNTLMQsEIEELRAALEQTERGRKVAEQE 1707
Cdd:COG4942   100 EAQKEELAEllralyrlgrqpplalllSPEDFLDAVRRLQYLK---YLAPARREQAE-ELRADLAELAALRAELEAERAE 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1708 LVDASERVGLLHSQNTSLLNTKKKLEADLVQIQSEVEDTVQEARNAEDKAKKAItDAAMMAEELKKEQDTSAHLERMKKN 1787
Cdd:COG4942   176 LEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALI-ARLEAEAAAAAERTPAAGFAALKGK 254

                  .
gi 288856329 1788 L 1788
Cdd:COG4942   255 L 255
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1692-1921 6.28e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 47.45  E-value: 6.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1692 AALEQTERGRKVAEQELVDASERVGLLHSQNTSLLNTKKKLEADLVQIQSEVEDTVQEARNAEDKAKKAITDAAMMAEEL 1771
Cdd:COG4942    20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1772 KKEQDTSAH----LERMKKNLEVTVKDLQHRLDEAENLAMKgGKKQLQKLESRVRELESEVEAEQRRGADAVKGVRKYER 1847
Cdd:COG4942   100 EAQKEELAEllraLYRLGRQPPLALLLSPEDFLDAVRRLQY-LKYLAPARREQAEELRADLAELAALRAELEAERAELEA 178
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 288856329 1848 RVKELTYQTEEDKKNVNRLQDLVDKLQLKVKAYKRQSEEAEEQANSHLSKLRKVQHELEEAEERADIAESQVNK 1921
Cdd:COG4942   179 LLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAAGFAALK 252
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
1294-1588 7.45e-05

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 47.61  E-value: 7.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1294 EEKEALVSQLtRGKQAFtqQIEELKRQIEEEVKAKnalahavqsarhdcdlLREQFEEEQEAKAELQRGMSKANSEVaqw 1373
Cdd:PRK05771   16 SYKDEVLEAL-HELGVV--HIEDLKEELSNERLRK----------------LRSLLTKLSEALDKLRSYLPKLNPLR--- 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1374 rtkyETDAIQRTEELEESKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQGEVEDLM------IDVERAN------ALA 1441
Cdd:PRK05771   74 ----EEKKKVSVKSLEELIKDVEEELEKIEKEIKELEEEISELENEIKELEQEIERLEpwgnfdLDLSLLLgfkyvsVFV 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1442 ANLDKkqRNFDKVLAEWKQKYEEGQAELEG-------AQKEARSLSTELFKmKNSYEE-TLDQLETLKRENKNLQQEISD 1513
Cdd:PRK05771  150 GTVPE--DKLEELKLESDVENVEYISTDKGyvyvvvvVLKELSDEVEEELK-KLGFERlELEEEGTPSELIREIKEELEE 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1514 LTEQLGETgksIHELEKSKKAVETekaEIQTALEEAEGTLEHEE--SKILR----VQLE-------LNQVKSEIDRKLAE 1580
Cdd:PRK05771  227 IEKERESL---LEELKELAKKYLE---ELLALYEYLEIELERAEalSKFLKtdktFAIEgwvpedrVKKLKELIDKATGG 300
                         330
                  ....*....|....*.
gi 288856329 1581 K--------DEEIEQI 1588
Cdd:PRK05771  301 SayvefvepDEEEEEV 316
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
1253-1409 7.80e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 46.07  E-value: 7.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1253 TLEDQLSEIKSKNDENLRQINDLSAQRARLQTENGEFGRQLEEKEALVSQLTRGKQAFTQQIEELKRQIEEEVKAK--NA 1330
Cdd:COG1579    14 ELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVRNNKeyEA 93
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 288856329 1331 LAHAVQSARHDCDLLREQFEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEESKKKLAQRLQEAEEQIEAV 1409
Cdd:COG1579    94 LQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREELAAKI 172
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
1486-1922 8.21e-05

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 48.02  E-value: 8.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1486 MKNSYE--ETLDQLETLKRENKNLQQEISDLTEQLGETGKSIHELEKSKKAVETEK-------AEIQTALEEAEgtlehe 1556
Cdd:COG3096   274 MRHANErrELSERALELRRELFGARRQLAEEQYRLVEMARELEELSARESDLEQDYqaasdhlNLVQTALRQQE------ 347
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1557 esKILRVQLELnqvkSEIDRKLAEKDEEIEQikRNSQRitdsmqstldSEVRSRNDAlrikkkMEGDLNEMEIQLshANR 1636
Cdd:COG3096   348 --KIERYQEDL----EELTERLEEQEEVVEE--AAEQL----------AEAEARLEA------AEEEVDSLKSQL--ADY 401
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1637 QAAEAQKQLRNVQAQlkdaqlhldDAVRGQEDMKEQVAMVERRNTLMQSEIEELRAALEQTERGRKVAEQELVDASERvg 1716
Cdd:COG3096   402 QQALDVQQTRAIQYQ---------QAVQALEKARALCGLPDLTPENAEDYLAAFRAKEQQATEEVLELEQKLSVADAA-- 470
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1717 llHSQNtsllntKKKLEAdLVQIQSEVEdtvqeARNAEDKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLevtvkdlq 1796
Cdd:COG3096   471 --RRQF------EKAYEL-VCKIAGEVE-----RSQAWQTARELLRRYRSQQALAQRLQQLRAQLAELEQRL-------- 528
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1797 HRLDEAENLAMKGGKKQLQKLESR--VRELESEVEAEQRR----GADAVKGVRKYERRVKELTYQTEEDKKNVNR---LQ 1867
Cdd:COG3096   529 RQQQNAERLLEEFCQRIGQQLDAAeeLEELLAELEAQLEEleeqAAEAVEQRSELRQQLEQLRARIKELAARAPAwlaAQ 608
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 288856329 1868 DLVDKLQLKVKAYKRQSEEAEEQANSHLSKLRKVQHELEEAEERADIAESQVNKL 1922
Cdd:COG3096   609 DALERLREQSGEALADSQEVTAAMQQLLEREREATVERDELAARKQALESQIERL 663
CCDC22 pfam05667
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ...
1213-1585 9.96e-05

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.


Pssm-ID: 461708 [Multi-domain]  Cd Length: 600  Bit Score: 47.33  E-value: 9.96e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1213 QRVKQKLEKEKSEYkmeiddLSSNMEAVAKAKANLEKMCRTLEDQLSEIKSKNDENLRQINDLSAQRA-RLQTENgefgr 1291
Cdd:pfam05667  242 KRKRTKLLKRIAEQ------LRSAALAGTEATSGASRSAQDLAELLSSFSGSSTTDTGLTKGSRFTHTeKLQFTN----- 310
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1292 qleEKEALVSQLTRGkqafTQQIEELKRQIEEEVKAknalahavqsarhdcdlLREQFEEEQEAKAELQRGMSKANSEVA 1371
Cdd:pfam05667  311 ---EAPAATSSPPTK----VETEEELQQQREEELEE-----------------LQEQLEDLESSIQELEKEIKKLESSIK 366
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1372 QwrTKYETDAIQRT-EELEES---KKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQGEVED----LMIDVERANALAAN 1443
Cdd:pfam05667  367 Q--VEEELEELKEQnEELEKQykvKKKTLDLLPDAEENIAKLQALVDASAQRLVELAGQWEKhrvpLIEEYRALKEAKSN 444
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1444 -LDKKQRNFDKvLAEWKQKYEEGQAELegaqkearslstelfKMKnsyEETLDQLETlkrENKNLQQEI--SDLTEQLGE 1520
Cdd:pfam05667  445 kEDESQRKLEE-IKELREKIKEVAEEA---------------KQK---EELYKQLVA---EYERLPKDVsrSAYTRRILE 502
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 288856329  1521 TGKSIHElekskkavetEKAEIQTALEEAEGtleheeskilrVQLELNQVKSEIDRKLAEKDEEI 1585
Cdd:pfam05667  503 IVKNIKK----------QKEEITKILSDTKS-----------LQKEINSLTGKLDRTFTVTDELV 546
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1727-1928 1.00e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 46.68  E-value: 1.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1727 NTKKKLEADLVQIQSEVEDTVQEARNAEDKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEVTVKDLQHRLDEAEnla 1806
Cdd:COG4942    20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELR--- 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1807 mkggkkqlQKLESRVRELESEVEAEQRRG--------------ADAVKGVRKYERRVKELTYQTEEDKKNVNRLQDLVDK 1872
Cdd:COG4942    97 --------AELEAQKEELAELLRALYRLGrqpplalllspedfLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAE 168
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 288856329 1873 LQLKVKAYKRQSEEAEEQANSHLSKLRKVQHELEEAEERADIAESQVNKLRAKSRD 1928
Cdd:COG4942   169 LEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEE 224
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
1633-1838 1.04e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 46.75  E-value: 1.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1633 HANRQAAEAQKQLRNVQAQLKDAQLHLDDAVRGQEDMKEQVAMVERRNTLMQSEIEELRAALEQtergrkvAEQELVDAS 1712
Cdd:COG3883    13 FADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAE-------AEAEIEERR 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1713 ERVG--LLHSQNTSLLNTkkKLEA--------DLVQIQSEVEDTVQEARNAEDKAKKAITDAAMMAEELKKEQDTsahLE 1782
Cdd:COG3883    86 EELGerARALYRSGGSVS--YLDVllgsesfsDFLDRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAE---LE 160
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 288856329 1783 RMKKNLEVTVKDLQHRLDEAENLaMKGGKKQLQKLESRVRELESEVEAEQRRGADA 1838
Cdd:COG3883   161 ALKAELEAAKAELEAQQAEQEAL-LAQLSAEEAAAEAQLAELEAELAAAEAAAAAA 215
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
882-1232 1.12e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 46.82  E-value: 1.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  882 LLQEKNDLQLAVASESENLSDAEERCEGLIKSKIQLEAKLKETTERLEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 961
Cdd:COG4372    15 LFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQA 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  962 TLAKVEKEKHATENKVKNLTEEMAAQDESIGKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKSKTKLEQQVDDLEGSLE 1041
Cdd:COG4372    95 ELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQ 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1042 QEKKLRMDLERAKRKLEGDLKLAQESIMDLENDKQQSEEKLKKKDFETSQLLSKIEDEQSLGAQLQKKIKELQARIEELE 1121
Cdd:COG4372   175 ALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEE 254
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1122 EEIEAERAARAKVEKQRADLSRELEEISERLEEAGGATAAQIEMNKKREAEFQKLRRDLEESTLQHEATAAALRKKQADS 1201
Cdd:COG4372   255 VILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLELAKKLELALAI 334
                         330       340       350
                  ....*....|....*....|....*....|.
gi 288856329 1202 VAELGEQIDNLQRVKQKLEKEKSEYKMEIDD 1232
Cdd:COG4372   335 LLAELADLLQLLLVGLLDNDVLELLSKGAEA 365
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1579-1809 1.16e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 46.68  E-value: 1.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1579 AEKDEEIEQIKRNSQRItDSMQSTLDSEVRSRNDALRIKKKMEGDLNEMEIQLSHANRQAAEAQKQLRNVQAQLKDAQLH 1658
Cdd:COG4942    20 DAAAEAEAELEQLQQEI-AELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1659 LDdavRGQEDMKEQVA---MVERRNTLM-------QSEIEELRAALEQTERGRKVAEQELVDASERvglLHSQNTSLLNT 1728
Cdd:COG4942    99 LE---AQKEELAELLRalyRLGRQPPLAlllspedFLDAVRRLQYLKYLAPARREQAEELRADLAE---LAALRAELEAE 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1729 KKKLEADLVQIQSEVEDTVQEARNAEDKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEVTVKDLQHRLDEAENLAMK 1808
Cdd:COG4942   173 RAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAAGFAALK 252

                  .
gi 288856329 1809 G 1809
Cdd:COG4942   253 G 253
PRK05035 PRK05035
electron transport complex protein RnfC; Provisional
1147-1414 1.20e-04

electron transport complex protein RnfC; Provisional


Pssm-ID: 235334 [Multi-domain]  Cd Length: 695  Bit Score: 47.25  E-value: 1.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1147 EISERLEEAGGATAAqiemnKKR-EAEFQKLRRDLEESTLQHEATAAALRKKQADSVAELgeqidnLQRVKQKLEKEKSE 1225
Cdd:PRK05035  437 EIRAIEQEKKKAEEA-----KARfEARQARLEREKAAREARHKKAAEARAAKDKDAVAAA------LARVKAKKAAATQP 505
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1226 YKMEIDDLSSNMEAVAKAKAnlekmcRTLEDQlseikskndenlrqindlsAQRARLQTENGEfgrqLEEKEALVSQLTR 1305
Cdd:PRK05035  506 IVIKAGARPDNSAVIAAREA------RKAQAR-------------------ARQAEKQAAAAA----DPKKAAVAAAIAR 556
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1306 GKQAFTQQIEELKRQIEEEVKAKNALAHAVqsARHDCDLLREQFEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRT 1385
Cdd:PRK05035  557 AKAKKAAQQAANAEAEEEVDPKKAAVAAAI--ARAKAKKAAQQAASAEPEEQVAEVDPKKAAVAAAIARAKAKKAEQQAN 634
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 288856329 1386 EELEES---------------KKKLAQRLQEAEEQIEAVNSKCA 1414
Cdd:PRK05035  635 AEPEEPvdprkaavaaaiaraKARKAAQQQANAEPEEAEDPKKA 678
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
1748-1928 1.22e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 47.24  E-value: 1.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1748 QEARNAED----KAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEVTVKDLQHRLDEAEnlamkggkKQLQKLESRVRE 1823
Cdd:COG1196   207 RQAEKAERyrelKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELE--------AELEELRLELEE 278
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1824 LESEVEAEQRRGADAVKGVRKYERRVKELTYQTEEDKKNVNRLQDLVDKLQLKVKAYKRQSEEAEEQANSHLSKLRKVQH 1903
Cdd:COG1196   279 LELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEA 358
                         170       180
                  ....*....|....*....|....*
gi 288856329 1904 ELEEAEERADIAESQVNKLRAKSRD 1928
Cdd:COG1196   359 ELAEAEEALLEAEAELAEAEEELEE 383
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
1255-1481 1.31e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 46.36  E-value: 1.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1255 EDQLSEIKSKNDENLRQINDLSAQRARLQTENGEFGRQLEEKEALVSQLTRGKQAFTQQIEELKRQIEEEVKAKNALAHA 1334
Cdd:COG3883    15 DPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARA 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1335 VQSARHDCDLLR--------EQFEEEQEAKAELQRGMSKANSEVAQWRTKYE---TDAIQRTEELEESKKKLAQRLQEAE 1403
Cdd:COG3883    95 LYRSGGSVSYLDvllgsesfSDFLDRLSALSKIADADADLLEELKADKAELEakkAELEAKLAELEALKAELEAAKAELE 174
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 288856329 1404 EQIEAVNSKCASLEKTKQRLQGEVEDLMIDVERANALAANLDKKQRNFDKVLAEWKQKYEEGQAELEGAQKEARSLST 1481
Cdd:COG3883   175 AQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAASAAGAGAA 252
PLN02939 PLN02939
transferase, transferring glycosyl groups
1574-1928 1.40e-04

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 47.20  E-value: 1.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1574 IDRKLAEKDEEIEQIKRNSQRITDSM--QSTLDSEVRSRNDALRIKKKMEGDLNemeiQLSHANRQAAEAQKQLRNVQAQ 1651
Cdd:PLN02939   61 SNSKLQSNTDENGQLENTSLRTVMELpqKSTSSDDDHNRASMQRDEAIAAIDNE----QQTNSKDGEQLSDFQLEDLVGM 136
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1652 LKDAQ---LHLDDA-VRGQEDMKEQVAMVERrntlMQSEIEELRAALEQTERGRKVAEQELVDAsERVGLLHSQNTSLLN 1727
Cdd:PLN02939  137 IQNAEkniLLLNQArLQALEDLEKILTEKEA----LQGKINILEMRLSETDARIKLAAQEKIHV-EILEEQLEKLRNELL 211
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1728 TKKKLEADLVQIQSEVEDTVQEarnaEDKAKKAitDAAMMAEELKKEQDTS---AHLERMKKNLEVTVKDLQHRLDEAEN 1804
Cdd:PLN02939  212 IRGATEGLCVHSLSKELDVLKE----ENMLLKD--DIQFLKAELIEVAETEervFKLEKERSLLDASLRELESKFIVAQE 285
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1805 LAMKGGKKQLQKLESRVRELESEVEAEQRRGADAV---KGVRKYERRVKELTYQTEEdkKNVNRLQ-DLVDKLQLKVKAY 1880
Cdd:PLN02939  286 DVSKLSPLQYDCWWEKVENLQDLLDRATNQVEKAAlvlDQNQDLRDKVDKLEASLKE--ANVSKFSsYKVELLQQKLKLL 363
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 288856329 1881 KRQSEEAEEQANSHlsklrkVQHELEEAEERADIAESQVNKLRAKSRD 1928
Cdd:PLN02939  364 EERLQASDHEIHSY------IQLYQESIKEFQDTLSKLKEESKKRSLE 405
WEMBL pfam05701
Weak chloroplast movement under blue light; WEMBL consists of several plant proteins required ...
1373-1921 1.47e-04

Weak chloroplast movement under blue light; WEMBL consists of several plant proteins required for the chloroplast avoidance response under high intensity blue light. This avoidance response consists in the relocation of chloroplasts on the anticlinal side of exposed cells. Acts in association with PMI2 to maintain the velocity of chloroplast photo-relocation movement via the regulation of cp-actin filaments. Thus several member-sequences are described as "myosin heavy chain-like".


Pssm-ID: 461718 [Multi-domain]  Cd Length: 562  Bit Score: 46.56  E-value: 1.47e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1373 WRTkYETDAIQRTEELEESKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQGEVEDLMIDVERANAlaanlDKKQRNFD 1452
Cdd:pfam05701   26 WKA-HRIQTVERRKLVELELEKVQEEIPEYKKQSEAAEAAKAQVLEELESTKRLIEELKLNLERAQT-----EEAQAKQD 99
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1453 KVLAEWK-QKYEEGqaeleGAQKEARSLSTELFKMKNSYEETLDQLETLKRENKNLQQEISDLTEQLGETGK----SIHE 1527
Cdd:pfam05701  100 SELAKLRvEEMEQG-----IADEASVAAKAQLEVAKARHAAAVAELKSVKEELESLRKEYASLVSERDIAIKraeeAVSA 174
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1528 LEKSKKAVETEKAEIQTALEEAEGT----LEHEESKIlRVQLELNQVKSEIDRKLAEKDEEIEQIkRNSQRITDSMQSTL 1603
Cdd:pfam05701  175 SKEIEKTVEELTIELIATKESLESAhaahLEAEEHRI-GAALAREQDKLNWEKELKQAEEELQRL-NQQLLSAKDLKSKL 252
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1604 DSevrsrNDALRIKKK------MEGDLNEMEIQLSHANRQAAEAQKQLRNVQAQLKDAQLHLDDAvrgqedmKEQVAMVE 1677
Cdd:pfam05701  253 ET-----ASALLLDLKaelaayMESKLKEEADGEGNEKKTSTSIQAALASAKKELEEVKANIEKA-------KDEVNCLR 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1678 RRNTLMQSEIEELRAALEQTERGRKVAEQelvdaservgllhsqntsllnTKKKLEADLVQIQSEVEdTVQEarnaedKA 1757
Cdd:pfam05701  321 VAAASLRSELEKEKAELASLRQREGMASI---------------------AVSSLEAELNRTKSEIA-LVQA------KE 372
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1758 KKAitdAAMMAEELKKEQDTSAHLERMKKNLEVTVKDLQHRLDEAENlamkgGKKQLQKLESRVRELESEVEA---EQRR 1834
Cdd:pfam05701  373 KEA---REKMVELPKQLQQAAQEAEEAKSLAQAAREELRKAKEEAEQ-----AKAAASTVESRLEAVLKEIEAakaSEKL 444
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1835 GADAVKGVRKYER---------RVKELTYQTEEDKKNVNRLQDLVDKLQLKVKAYKRQSEEAEEQANSHLSKLRKVQHEL 1905
Cdd:pfam05701  445 ALAAIKALQESESsaestnqedSPRGVTLSLEEYYELSKRAHEAEELANKRVAEAVSQIEEAKESELRSLEKLEEVNREM 524
                          570
                   ....*....|....*.
gi 288856329  1906 EEAEERADIAESQVNK 1921
Cdd:pfam05701  525 EERKEALKIALEKAEK 540
PRK11637 PRK11637
AmiB activator; Provisional
926-1096 1.48e-04

AmiB activator; Provisional


Pssm-ID: 236942 [Multi-domain]  Cd Length: 428  Bit Score: 46.61  E-value: 1.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  926 ERLEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATEnkvKNLTEEMAA---QDESIG---KLTKEKK 999
Cdd:PRK11637   75 AQLKKQEEAISQASRKLRETQNTLNQLNKQIDELNASIAKLEQQQAAQE---RLLAAQLDAafrQGEHTGlqlILSGEES 151
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1000 ALQEAHQQTLDDL-QAEEDKVNTLTKSKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDLENDKQQS 1078
Cdd:PRK11637  152 QRGERILAYFGYLnQARQETIAELKQTREELAAQKAELEEKQSQQKTLLYEQQAQQQKLEQARNERKKTLTGLESSLQKD 231
                         170
                  ....*....|....*...
gi 288856329 1079 EEKLKKKDFETSQLLSKI 1096
Cdd:PRK11637  232 QQQLSELRANESRLRDSI 249
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
884-1081 1.65e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 46.36  E-value: 1.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  884 QEKNDLQLAVASESENLSDAEERCEGLIKSKIQLEAKLKETTERLedeEEINAELTAKKRKLEDECSELKKDIDDLELT- 962
Cdd:COG3883    23 KELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEI---DKLQAEIAEAEAEIEERREELGERARALYRSg 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  963 -----LAKVEKEKHATE--NKVKNLTEEMAAQDESIGKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKSKTKLEQQVDD 1035
Cdd:COG3883   100 gsvsyLDVLLGSESFSDflDRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQAE 179
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 288856329 1036 LEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDLENDKQQSEEK 1081
Cdd:COG3883   180 QEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAA 225
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
1022-1551 1.86e-04

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 46.27  E-value: 1.86e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1022 LTKSKTKLEQQVDDLEGSLEQEKKLRMDLERA----KRKLEGDLKLAQESIMDLENDKQQSEEKLKKKDFETSQLLSKIE 1097
Cdd:pfam05557    4 LIESKARLSQLQNEKKQMELEHKRARIELEKKasalKRQLDRESDRNQELQKRIRLLEKREAEAEEALREQAELNRLKKK 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1098 DEQSLGAQLQKKIKELQARIEELEEEIEAERAARAKVEKQRADLSRELEEIsERLEEaggataaQIEMNKKREAEFQKLR 1177
Cdd:pfam05557   84 YLEALNKKLNEKESQLADAREVISCLKNELSELRRQIQRAELELQSTNSEL-EELQE-------RLDLLKAKASEAEQLR 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1178 RDLEEStlQHEATAAALRKK--------QADSVAELG------EQIDNLQRVKQKLEKEKSEY----------KMEIDDL 1233
Cdd:pfam05557  156 QNLEKQ--QSSLAEAEQRIKelefeiqsQEQDSEIVKnskselARIPELEKELERLREHNKHLnenienklllKEEVEDL 233
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1234 SSNMEAVAKAKANLEKMCRTLEDQLSEIKS------KNDENLRQINDLSAQRARLQT-------ENGEFGRQLEEKEALV 1300
Cdd:pfam05557  234 KRKLEREEKYREEAATLELEKEKLEQELQSwvklaqDTGLNLRSPEDLSRRIEQLQQreivlkeENSSLTSSARQLEKAR 313
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1301 SQLTRGKQAFTQQIEELKRQIEEEVKAKNALAHAVQSARHDCDLLREQFEeeqeakaelqrgmsKANSEVAQwrTKYETD 1380
Cdd:pfam05557  314 RELEQELAQYLKKIEDLNKKLKRHKALVRRLQRRVLLLTKERDGYRAILE--------------SYDKELTM--SNYSPQ 377
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1381 AIQRTEELEESKKKLAQRLQEAEEQIEAvnskcASLEKTKQRLQGEVEDLMIDVERANALAANLDKKQRNFDKVlaewKQ 1460
Cdd:pfam05557  378 LLERIEEAEDMTQKMQAHNEEMEAQLSV-----AEEELGGYKQQAQTLERELQALRQQESLADPSYSKEEVDSL----RR 448
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1461 KYEEGQAELEGAQKEARSLSTEL--------FKMKNS-------------YEETLDQLETLKRENKNLQQEISDLTEQLg 1519
Cdd:pfam05557  449 KLETLELERQRLREQKNELEMELerrclqgdYDPKKTkvlhlsmnpaaeaYQQRKNQLEKLQAEIERLKRLLKKLEDDL- 527
                          570       580       590
                   ....*....|....*....|....*....|..
gi 288856329  1520 ETGKSIHelEKSKKAVETEKAEIQTALEEAEG 1551
Cdd:pfam05557  528 EQVLRLP--ETTSTMNFKEVLDLRKELESAEL 557
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1752-1931 2.20e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 46.21  E-value: 2.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1752 NAEDKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEVTVKDLQHRLDEAENLAMKGGKKqLQKLESRVRELE---SEV 1828
Cdd:PRK03918  162 NAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREE-LEKLEKEVKELEelkEEI 240
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1829 EAEQRRGADAVKGVRKYERRVKELTYQTEEDKKNVNRLQDLVDKLQlKVKAYKRQSEEAEEQANSHLSKLRKVQHELEEA 1908
Cdd:PRK03918  241 EELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELK-ELKEKAEEYIKLSEFYEEYLDELREIEKRLSRL 319
                         170       180
                  ....*....|....*....|...
gi 288856329 1909 EERADIAESQVNKLRAKSRDSGK 1931
Cdd:PRK03918  320 EEEINGIEERIKELEEKEERLEE 342
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1561-1803 2.58e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 46.16  E-value: 2.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1561 LRVQLELNQvkSEIDRKLAEKDEEIEQIKRNSQRITDSMQstldsEVRSRNDALRIkkkmEGDLNEMEIQLSHANRQAAE 1640
Cdd:COG3206   162 LEQNLELRR--EEARKALEFLEEQLPELRKELEEAEAALE-----EFRQKNGLVDL----SEEAKLLLQQLSELESQLAE 230
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1641 AQKQLRNVQAQLkdaqlhldDAVRGQEDMKEQVAMVERRNTLMQseieELRAALEQtergrkvAEQELVDASERVGLLHS 1720
Cdd:COG3206   231 ARAELAEAEARL--------AALRAQLGSGPDALPELLQSPVIQ----QLRAQLAE-------LEAELAELSARYTPNHP 291
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1721 QntsLLNTKKKLEADLVQIQSEVEDTVQEARNAEDKAKKAITDAAMMAEELKKE----QDTSAHLERMKKNLEVTVK--- 1793
Cdd:COG3206   292 D---VIALRAQIAALRAQLQQEAQRILASLEAELEALQAREASLQAQLAQLEARlaelPELEAELRRLEREVEVARElye 368
                         250
                  ....*....|
gi 288856329 1794 DLQHRLDEAE 1803
Cdd:COG3206   369 SLLQRLEEAR 378
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
950-1274 2.73e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 45.28  E-value: 2.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  950 SELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAAQDESIGKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKSKTKL 1029
Cdd:COG4372    27 AALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESL 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1030 EQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDLENDKQQSEEKLKKKDFETSQLLSKIEDEQSLGAQLQKK 1109
Cdd:COG4372   107 QEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEAEQALD 186
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1110 IKELQARIEELEEEIEAERAARAKVEKQRADLSRELEEISERLEEAGGATAAQIEMNKKREAEFQKLRRDLEESTLQHEA 1189
Cdd:COG4372   187 ELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELA 266
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1190 TAAALRKKQADSVAELGEQIDNLQRVKQKLEKEKSEYKMEIDDLSSNMEAVAKAKANLEKMCRTLEDQLSEIKSKNDENL 1269
Cdd:COG4372   267 ILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLELAKKLELALAILLAELADLLQLL 346

                  ....*
gi 288856329 1270 RQIND 1274
Cdd:COG4372   347 LVGLL 351
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
1103-1859 3.19e-04

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 46.10  E-value: 3.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1103 GAQLQKKIKELQARIEELEEEIEAERAARAKVEKQRADLSRELEEISERLEEAGGATA---AQIEMNKKREAEFQKLRRD 1179
Cdd:COG3096   342 ALRQQEKIERYQEDLEELTERLEEQEEVVEEAAEQLAEAEARLEAAEEEVDSLKSQLAdyqQALDVQQTRAIQYQQAVQA 421
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1180 LEESTLQHEA---TAAALRKKQADSVAELGEQIDNLQRVKQKL---EKEKSEYK--ME----IDDLSSNMEAVAKAKANL 1247
Cdd:COG3096   422 LEKARALCGLpdlTPENAEDYLAAFRAKEQQATEEVLELEQKLsvaDAARRQFEkaYElvckIAGEVERSQAWQTARELL 501
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1248 EKM--CRTLEDQLSEIKSKndenLRQINDLSAQRARLQTENGEFGRQLEEKEALVSQLTRGKQAFTQQIEELKRQIEEEV 1325
Cdd:COG3096   502 RRYrsQQALAQRLQQLRAQ----LAELEQRLRQQQNAERLLEEFCQRIGQQLDAAEELEELLAELEAQLEELEEQAAEAV 577
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1326 KAKNALAHAVQSARHDCDLLREQFEEEQEAKAELQR--GMSKANSEVAQWRTKYETDAIQRTEELEESKKKLAQRLQEAE 1403
Cdd:COG3096   578 EQRSELRQQLEQLRARIKELAARAPAWLAAQDALERlrEQSGEALADSQEVTAAMQQLLEREREATVERDELAARKQALE 657
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1404 EQIEAVN----SKCASLEKTKQRLQGEV-----EDLMI--------------------DVERANALAANLDKK------- 1447
Cdd:COG3096   658 SQIERLSqpggAEDPRLLALAERLGGVLlseiyDDVTLedapyfsalygparhaivvpDLSAVKEQLAGLEDCpedlyli 737
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1448 QRN---FDKVLAEWKqkyeegqaELEGA---QKEARSL------STELFKMKnSYEEtldQLETLKRENKNLQQEISDLT 1515
Cdd:COG3096   738 EGDpdsFDDSVFDAE--------ELEDAvvvKLSDRQWrysrfpEVPLFGRA-AREK---RLEELRAERDELAEQYAKAS 805
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1516 EQLGETGKSIHELEK---SKKAV------ETEKAEIQTALEEAEGTLEHEESKILRVQLELNQVKSEID--RKLAE---- 1580
Cdd:COG3096   806 FDVQKLQRLHQAFSQfvgGHLAVafapdpEAELAALRQRRSELERELAQHRAQEQQLRQQLDQLKEQLQllNKLLPqanl 885
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1581 -KDEEIEqikrnsQRITDsmqstLDSEVRSRNDALRIKKKMEGDLNEMEIQLS--------HANRQAA--EAQKQLRNVQ 1649
Cdd:COG3096   886 lADETLA------DRLEE-----LREELDAAQEAQAFIQQHGKALAQLEPLVAvlqsdpeqFEQLQADylQAKEQQRRLK 954
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1650 AQLkDAqlhLDDAVRGQEDM--KEQVAMVERRNTLmqseIEELRAALEQTERGRKVAEQELVDASERvgllHSQNTSLLn 1727
Cdd:COG3096   955 QQI-FA---LSEVVQRRPHFsyEDAVGLLGENSDL----NEKLRARLEQAEEARREAREQLRQAQAQ----YSQYNQVL- 1021
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1728 tkkkleADLVQIQSEVEDTVQEA-RNAEDKAKKAITDAAMMAEELKKEQDTSAHLERMKKN-LEvtvKDLQHRldEAEnl 1805
Cdd:COG3096  1022 ------ASLKSSRDAKQQTLQELeQELEELGVQADAEAEERARIRRDELHEELSQNRSRRSqLE---KQLTRC--EAE-- 1088
                         810       820       830       840       850
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 288856329 1806 aMKGGKKQLQKLESRVRELESEVEAEQRRGADAVKGVRKY--ERRV--KELTYQTEED 1859
Cdd:COG3096  1089 -MDSLQKRLRKAERDYKQEREQVVQAKAGWCAVLRLARDNdvERRLhrRELAYLSADE 1145
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
1189-1418 3.22e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 45.21  E-value: 3.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1189 ATAAALRKKQADSVAELGEQIDNLQRVKQKLEKEKSEYKMEIDDLSsnmEAVAKAKANLEKmcrtLEDQLSEIKskndEN 1268
Cdd:COG3883    12 AFADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQ---AELEALQAEIDK----LQAEIAEAE----AE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1269 LRQINDLSAQRARLQTENGEFGRQLE------------EKEALVSQLTRGKQAFTQQIEELKRQIEEevkAKNALAHAVQ 1336
Cdd:COG3883    81 IEERREELGERARALYRSGGSVSYLDvllgsesfsdflDRLSALSKIADADADLLEELKADKAELEA---KKAELEAKLA 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1337 SarhdcdlLREQFEEEQEAKAELQRGMSKANSEVAQWRTKyETDAIQRTEELEESKKKLAQRLQEAEEQIEAVNSKCASL 1416
Cdd:COG3883   158 E-------LEALKAELEAAKAELEAQQAEQEALLAQLSAE-EAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAA 229

                  ..
gi 288856329 1417 EK 1418
Cdd:COG3883   230 AA 231
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
1133-1282 3.25e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 44.53  E-value: 3.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1133 KVEKQRADLSRELEEISERLEEAggatAAQIEMNKKREAEFQKLRRDLEESTLQHEATAAALRKKQ-----ADSVAELGE 1207
Cdd:COG1579    21 RLEHRLKELPAELAELEDELAAL----EARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLgnvrnNKEYEALQK 96
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 288856329 1208 QIDNLQRVKQKLEKEKSEYKMEIDDLSsnmEAVAKAKANLEKMCRTLEDQLSEIKSKNDENLRQINDLSAQRARL 1282
Cdd:COG1579    97 EIESLKRRISDLEDEILELMERIEELE---EELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREEL 168
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
911-1186 3.33e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 45.50  E-value: 3.33e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   911 IKSKIQLEAKLKETTERLEDEEEINAELTAKKRKLEDECSELKKDID--------------DLELTLAKVEKEKHATENK 976
Cdd:pfam17380  284 VSERQQQEKFEKMEQERLRQEKEEKAREVERRRKLEEAEKARQAEMDrqaaiyaeqermamERERELERIRQEERKRELE 363
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   977 vKNLTEEMAAQDESIGKLTKEKKALQEAHQQTLDDLQA-------EEDKVNTLTKSKTKLEQQVDDLEGSLEQEKKlRMD 1049
Cdd:pfam17380  364 -RIRQEEIAMEISRMRELERLQMERQQKNERVRQELEAarkvkilEEERQRKIQQQKVEMEQIRAEQEEARQREVR-RLE 441
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1050 LERAkRKLEGDLKLAQESIMDLENDKQQSEEKLKKKdfetsQLLSKIEDEQSLGAQLQKKI--KELQARIEELEEEIEAE 1127
Cdd:pfam17380  442 EERA-REMERVRLEEQERQQQVERLRQQEEERKRKK-----LELEKEKRDRKRAEEQRRKIleKELEERKQAMIEEERKR 515
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 288856329  1128 RAARAKVEKQRADLSREleeisERLEEAGGATAAQIEMNKKREAEFQKLRRDLEESTLQ 1186
Cdd:pfam17380  516 KLLEKEMEERQKAIYEE-----ERRREAEEERRKQQEMEERRRIQEQMRKATEERSRLE 569
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
982-1756 3.56e-04

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 45.71  E-value: 3.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  982 EEMAAQDESIGKLTKEKKALQEAHQQTLDDLQAEED---KVNTLTKSKTKLEQQVDDLEgsleqekklrmDLERAKRKLE 1058
Cdd:COG3096   299 RQLAEEQYRLVEMARELEELSARESDLEQDYQAASDhlnLVQTALRQQEKIERYQEDLE-----------ELTERLEEQE 367
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1059 GDLKLAQESIMDLENDKQQSEEklkkkdfETSQLLSKIED-EQSLGAQLQKKIKELQARIEELEEEIEAeraarakvekQ 1137
Cdd:COG3096   368 EVVEEAAEQLAEAEARLEAAEE-------EVDSLKSQLADyQQALDVQQTRAIQYQQAVQALEKARALC----------G 430
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1138 RADLSreLEEISERLEEAggATAAQIEMNKKREAEfQKLRrDLEESTLQHEATAAALRK-------KQADSVA-ELGEQI 1209
Cdd:COG3096   431 LPDLT--PENAEDYLAAF--RAKEQQATEEVLELE-QKLS-VADAARRQFEKAYELVCKiageverSQAWQTArELLRRY 504
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1210 DNLQRVKQKLEKEKSEYKmeidDLSSNMEAVAKAKANLEKMCRTLEDQLSEIkskndenlrqiNDLSAQRARLQTENGEF 1289
Cdd:COG3096   505 RSQQALAQRLQQLRAQLA----ELEQRLRQQQNAERLLEEFCQRIGQQLDAA-----------EELEELLAELEAQLEEL 569
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1290 GRQLEEKEALVSQLTRGKQAFTQQIEELKRQIEEEVKAKNALAHavqsarhdcdlLREQFEEEQEAKAELQRGMSKAnse 1369
Cdd:COG3096   570 EEQAAEAVEQRSELRQQLEQLRARIKELAARAPAWLAAQDALER-----------LREQSGEALADSQEVTAAMQQL--- 635
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1370 vaqwrtkyetdaIQRTEELEESKKKLAQRLQEAEEQIEAVN----SKCASLEKTKQRLQGEV-----EDLMI-------- 1432
Cdd:COG3096   636 ------------LEREREATVERDELAARKQALESQIERLSqpggAEDPRLLALAERLGGVLlseiyDDVTLedapyfsa 703
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1433 ------------DVERANALAANLDKK-------QRN---FDKVLAEWKqkyeegqaELEGA---QKEARSL------ST 1481
Cdd:COG3096   704 lygparhaivvpDLSAVKEQLAGLEDCpedlyliEGDpdsFDDSVFDAE--------ELEDAvvvKLSDRQWrysrfpEV 775
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1482 ELFKMKnSYEEtldQLETLKRENKNLQQEISDLTEQLGETGKSIHELEK---SKKAV------ETEKAEIQTALEEAEGT 1552
Cdd:COG3096   776 PLFGRA-AREK---RLEELRAERDELAEQYAKASFDVQKLQRLHQAFSQfvgGHLAVafapdpEAELAALRQRRSELERE 851
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1553 LEHEESKILRVQLELNQVKSEI--------------DRKLAEKDEEIEQ-----------IKRNSQRIT--DSMQSTLDS 1605
Cdd:COG3096   852 LAQHRAQEQQLRQQLDQLKEQLqllnkllpqanllaDETLADRLEELREeldaaqeaqafIQQHGKALAqlEPLVAVLQS 931
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1606 ------------------------------EVRSR------NDALRIKKKmEGDLNE-MEIQLSHANRQAAEAQKQLRNV 1648
Cdd:COG3096   932 dpeqfeqlqadylqakeqqrrlkqqifalsEVVQRrphfsyEDAVGLLGE-NSDLNEkLRARLEQAEEARREAREQLRQA 1010
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1649 QAQLKDAQLHLDDAVRGQEDMKEQVAMVERrntlmqsEIEEL--RAALEQTERGRkvaeqelvdasERVGLLHSQNTSLL 1726
Cdd:COG3096  1011 QAQYSQYNQVLASLKSSRDAKQQTLQELEQ-------ELEELgvQADAEAEERAR-----------IRRDELHEELSQNR 1072
                         890       900       910
                  ....*....|....*....|....*....|
gi 288856329 1727 NTKKKLEADLVQIQSEVEDTVQEARNAEDK 1756
Cdd:COG3096  1073 SRRSQLEKQLTRCEAEMDSLQKRLRKAERD 1102
46 PHA02562
endonuclease subunit; Provisional
885-1092 3.59e-04

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 45.39  E-value: 3.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  885 EKNDLQLAVASESENLSDAEErcegliKSKIQLEAKLKETTERLEDEEEINAELTakkrKLEDECSELKKDIDDLELTLA 964
Cdd:PHA02562  189 KIDHIQQQIKTYNKNIEEQRK------KNGENIARKQNKYDELVEEAKTIKAEIE----ELTDELLNLVMDIEDPSAALN 258
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  965 KVEKEKHATENKVKNLTEEM----------------AAQDESIGKLTKEKKALQ---EAHQQTLDDLQAEEDKVNTLTKS 1025
Cdd:PHA02562  259 KLNTAAAKIKSKIEQFQKVIkmyekggvcptctqqiSEGPDRITKIKDKLKELQhslEKLDTAIDELEEIMDEFNEQSKK 338
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 288856329 1026 ----KTKLEQQVDDLEGSLEQEKKLRMDLERAKRKL---EGDLKLAQESIMDLENDKQQSEEKLKKKDFETSQL 1092
Cdd:PHA02562  339 llelKNKISTNKQSLITLVDKAKKVKAAIEELQAEFvdnAEELAKLQDELDKIVKTKSELVKEKYHRGIVTDLL 412
EcCorA_ZntB-like cd12821
Escherichia coli CorA-Salmonella typhimurium ZntB_like family; A family of the MIT superfamily ...
1297-1409 4.03e-04

Escherichia coli CorA-Salmonella typhimurium ZntB_like family; A family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of this family are found in all three kingdoms of life. It is a functionally diverse family, including the Mg2+ transporters Escherichia coli and Salmonella typhimurium CorAs (which can also transport Co2+, and Ni2+ ), and the Zn2+ transporter Salmonella typhimurium ZntB which mediates the efflux of Zn2+ (and Cd2+). It also includes two Saccharomyces cerevisiae members: the inner membrane Mg2+ transporters Mfm1p/Lpe10p, and Mrs2p, and a family of Arabidopsis thaliana members (AtMGTs) some of which are localized to distinct tissues, and not all of which can transport Mg2+. Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213355 [Multi-domain]  Cd Length: 285  Bit Score: 44.62  E-value: 4.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1297 EALVSQLTRGKQAFTQQIEELKRQIEEEVKAKnALAHAVqSARHDCDLLREQFEEEQEAKAELQRGMSKANSEvaqwrTK 1376
Cdd:cd12821   110 GAIIKALLTGIDQFEEKLEELEWDLLEGNNAI-KLDRIL-ELRRELLRLTNLIEPQQEVLMALQEAFAELLFS-----ED 182
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 288856329 1377 YET--DAIQRTEELEESKKKLAQRLQEAEEQIEAV 1409
Cdd:cd12821   183 EEElrRTLDRIERLLQLIEEYEQELDTLQDIEEVV 217
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1573-1937 4.21e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 44.89  E-value: 4.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1573 EIDRKLAEKDEEIEQIKRNSQRITDSMQSTLDSEVRSRNDALRIKKKMEGDLNEMEIQLSHANRQAAEAQKQLRNVQAQL 1652
Cdd:COG4372     3 RLGEKVGKARLSLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEEL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1653 KDAQLHLDDAVRGQEDMKEQVAMVERRNTLMQSEIEELRAALEQTERGRKVAEQELVDASERVGLLHSQNTSLLNTKKKL 1732
Cdd:COG4372    83 EELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESL 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1733 EADLVQIQSEVEDTVQEARNAEDKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEVTVKDLQHRLDEAENLAMKGGKK 1812
Cdd:COG4372   163 QEELAALEQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDAL 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1813 QLQKLESRVRELESEVEAEQRRGADAVKGVRKYERRVKELTYQTEEDKKNVNRLQDLVDKLQLKVKAYKRQSEEAEEQAN 1892
Cdd:COG4372   243 ELEEDKEELLEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALL 322
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 288856329 1893 SHLSKLRKVQHELEEAEERADIAESQVNKLRAKSRDSGKGKDAAE 1937
Cdd:COG4372   323 ELAKKLELALAILLAELADLLQLLLVGLLDNDVLELLSKGAEAGV 367
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
1283-1810 4.43e-04

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 45.33  E-value: 4.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1283 QTENGEFGRQLEEKEALVSQltrgkqAFTQQIEELKRQIEEEVKAKNALAHAvqsarhdcdllREQFEEEQEAKAELQRG 1362
Cdd:COG3096   252 QSDRDLFKHLITEATNYVAA------DYMRHANERRELSERALELRRELFGA-----------RRQLAEEQYRLVEMARE 314
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1363 MskansevaqwrtkyetdaiqrtEELEESKKKLAQRLQEAEEQIEAVNSKCASLEKTkQRLQGEVEDLMIDVERANAlaa 1442
Cdd:COG3096   315 L----------------------EELSARESDLEQDYQAASDHLNLVQTALRQQEKI-ERYQEDLEELTERLEEQEE--- 368
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1443 nldkkqrnfdkVLAEWKQKYEEGQAELEGAQKEARSLSTELfkmkNSYEETLDQLETlkrenknlqqeisdlteqlgetg 1522
Cdd:COG3096   369 -----------VVEEAAEQLAEAEARLEAAEEEVDSLKSQL----ADYQQALDVQQT----------------------- 410
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1523 ksihelekskKAVETEKAeiQTALEEAEGTLEHEEskilrvqLELNQVKSEIDRKLAEKDEEIEQIKRNSQRITDSmqst 1602
Cdd:COG3096   411 ----------RAIQYQQA--VQALEKARALCGLPD-------LTPENAEDYLAAFRAKEQQATEEVLELEQKLSVA---- 467
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1603 lDSEVRSRNDALRIKKKMEGdlnemEIQLSHANRQAAEAQKQLRNVQAQLKDAQ---LHLDDA---VRGQEDMKEQVAMV 1676
Cdd:COG3096   468 -DAARRQFEKAYELVCKIAG-----EVERSQAWQTARELLRRYRSQQALAQRLQqlrAQLAELeqrLRQQQNAERLLEEF 541
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1677 ERRNTLMQSEIEELRAALEQTERGRKVAEQELVDASERVGLLHSQntsllntkkkLEADLVQIQsEVEDTVQEARNAEDK 1756
Cdd:COG3096   542 CQRIGQQLDAAEELEELLAELEAQLEELEEQAAEAVEQRSELRQQ----------LEQLRARIK-ELAARAPAWLAAQDA 610
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 288856329 1757 AKKAitdAAMMAEELKKEQDTSAHLERMKKNL-EVTV-KDL-----QHRLDEAENLAMKGG 1810
Cdd:COG3096   611 LERL---REQSGEALADSQEVTAAMQQLLERErEATVeRDElaarkQALESQIERLSQPGG 668
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
848-1698 5.04e-04

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 45.43  E-value: 5.04e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   848 EKELATMKEDFVKCKED------------------------LAKAEAKKKELEEKMVALLQEKNDLQLAVASESENLSDA 903
Cdd:TIGR01612  764 EKELSNKINDYAKEKDElnkykskiseiknhyndqinidniKDEDAKQNYDKSKEYIKTISIKEDEIFKIINEMKFMKDD 843
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   904 eerceglIKSKIQLEAKLKET-TERLEDEEEINAELTAK-KRKLEDE-CSELKKDIDD----LELTLAKVEKEKH--ATE 974
Cdd:TIGR01612  844 -------FLNKVDKFINFENNcKEKIDSEHEQFAELTNKiKAEISDDkLNDYEKKFNDskslINEINKSIEEEYQniNTL 916
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   975 NKVKNLTEEMAAQDESIGKLTKEKKALQEAHQQTLDDL-------QAEEDKV-NTLTKSKTKLEQQVDDLegSLEQEKKL 1046
Cdd:TIGR01612  917 KKVDEYIKICENTKESIEKFHNKQNILKEILNKNIDTIkesnlieKSYKDKFdNTLIDKINELDKAFKDA--SLNDYEAK 994
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1047 RMDLERAKRKLEGDLKLAQESIMdlendKQQSEEKLKKkdfeTSQLLSKIED--------EQSLGAQLQKKIKELQARIE 1118
Cdd:TIGR01612  995 NNELIKYFNDLKANLGKNKENML-----YHQFDEKEKA----TNDIEQKIEDanknipniEIAIHTSIYNIIDEIEKEIG 1065
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1119 ELEEEIEAERaarakVEKQRADLSrELEEISERLEEAGGATAAQiEMNKKREAEFQKLRRDLEESTLQHEATAAAL---R 1195
Cdd:TIGR01612 1066 KNIELLNKEI-----LEEAEINIT-NFNEIKEKLKHYNFDDFGK-EENIKYADEINKIKDDIKNLDQKIDHHIKALeeiK 1138
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1196 KKQADSVAELGEQIDNLQRVKQK-LEKEKSEykmEIDDLSSNMEAVAKAKANLEKMCRTLEDQLSEIKsKNDENLRQIND 1274
Cdd:TIGR01612 1139 KKSENYIDEIKAQINDLEDVADKaISNDDPE---EIEKKIENIVTKIDKKKNIYDEIKKLLNEIAEIE-KDKTSLEEVKG 1214
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1275 LSAQRArlQTENGEFGRQLEEKEALVSQLTRGKQAFTQQIEELKRQ---------IEEEVKAK-NAL--------AHAVQ 1336
Cdd:TIGR01612 1215 INLSYG--KNLGKLFLEKIDEEKKKSEHMIKAMEAYIEDLDEIKEKspeienemgIEMDIKAEmETFnishdddkDHHII 1292
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1337 SARHDCDL---------LREQFEEE---QEAKAELQRGMS---KANSEVAQWRTKYET---------------DAIQRTE 1386
Cdd:TIGR01612 1293 SKKHDENIsdirekslkIIEDFSEEsdiNDIKKELQKNLLdaqKHNSDINLYLNEIANiynilklnkikkiidEVKEYTK 1372
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1387 ELEESKKKLAQRLQEAEEQIEAVNSKcASLEKTKQRLQGEVEDLMID--------------------------------- 1433
Cdd:TIGR01612 1373 EIEENNKNIKDELDKSEKLIKKIKDD-INLEECKSKIESTLDDKDIDecikkikelknhilseesnidtyfknadennen 1451
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1434 -------VERANALAANLDKKQRN-----FDKVLAEWKQKYEEGQAELEGAQKEARSL--STELFK-------------- 1485
Cdd:TIGR01612 1452 vlllfknIEMADNKSQHILKIKKDnatndHDFNINELKEHIDKSKGCKDEADKNAKAIekNKELFEqykkdvtellnkys 1531
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1486 ---MKNSYEETLDQLETLKRENKNLQQEIsdlTEQLGETGKSIHELEKSKKAVETEKA---EIQTALEEAEGTLEHEESK 1559
Cdd:TIGR01612 1532 alaIKNKFAKTKKDSEIIIKEIKDAHKKF---ILEAEKSEQKIKEIKKEKFRIEDDAAkndKSNKAAIDIQLSLENFENK 1608
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1560 ILRVqlelnqvkSEIDRKLAEKDEEIEQIKRnsqRITDSMQSTLDSEVRSRNDALrikkkmeGDLNEMEIQLSHANRQAA 1639
Cdd:TIGR01612 1609 FLKI--------SDIKKKINDCLKETESIEK---KISSFSIDSQDTELKENGDNL-------NSLQEFLESLKDQKKNIE 1670
                          970       980       990      1000      1010
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 288856329  1640 EAQKQLRNVQAQLKDAQLHLDdavrgQEDMKEQVAMVERRNTLMQSEIEELRAALEQTE 1698
Cdd:TIGR01612 1671 DKKKELDELDSEIEKIEIDVD-----QHKKNYEIGIIEKIKEIAIANKEEIESIKELIE 1724
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
1298-1594 5.13e-04

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 45.00  E-value: 5.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1298 ALVSQLTRGKQAFTQQIEELKRQIEEEV--KAKNALAHAVQSARHDCDLLREQFEE------EQEAKAELQRGMSKANSE 1369
Cdd:NF033838   88 ALNKKLSDIKTEYLYELNVLKEKSEAELtsKTKKELDAAFEQFKKDTLEPGKKVAEatkkveEAEKKAKDQKEEDRRNYP 167
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1370 VAQWRT----KYETDAIQRTEELEESKKKL-----AQRLQEAEEQIEAVNSKCASLEKTK-QRLQGEVE-DLMIDVERAN 1438
Cdd:NF033838  168 TNTYKTleleIAESDVEVKKAELELVKEEAkeprdEEKIKQAKAKVESKKAEATRLEKIKtDREKAEEEaKRRADAKLKE 247
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1439 ALAANLDKKQRnfDKVLAEWKQKYEEGQAELEGAQKEARSLSTELfkmknsYEETLDQlETLKRENKNLQQEISdlTEQL 1518
Cdd:NF033838  248 AVEKNVATSEQ--DKPKRRAKRGVLGEPATPDKKENDAKSSDSSV------GEETLPS-PSLKPEKKVAEAEKK--VEEA 316
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1519 GETGKSIHELEK------SKKAVETEKAEIQTALEEAEGTLEHEESKILRVQLELNQVKSEIDRKLAEKdEEIEQIKRNS 1592
Cdd:NF033838  317 KKKAKDQKEEDRrnyptnTYKTLELEIAESDVKVKEAELELVKEEAKEPRNEEKIKQAKAKVESKKAEA-TRLEKIKTDR 395

                  ..
gi 288856329 1593 QR 1594
Cdd:NF033838  396 KK 397
CHASE3 COG5278
Extracytoplasmic sensor domain CHASE3 (specificity unknown) [Signal transduction mechanisms];
1357-1803 6.04e-04

Extracytoplasmic sensor domain CHASE3 (specificity unknown) [Signal transduction mechanisms];


Pssm-ID: 444089 [Multi-domain]  Cd Length: 530  Bit Score: 44.51  E-value: 6.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1357 AELQRGMSKANSEVAQWRTKYETDAIQRtEELEESKKKLAQRLQEAEEQIEAVNSKCASlEKTKQRLQGEVEDLM----- 1431
Cdd:COG5278    79 EPYEEARAEIDELLAELRSLTADNPEQQ-ARLDELEALIDQWLAELEQVIALRRAGGLE-AALALVRSGEGKALMdeira 156
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1432 IDVERANALAANLDKKQRNFDKVLAEWKQKYEEGQAELEGAQKEARSLSTELFKMKNSYEETLDQLETLKRENKNLQQEI 1511
Cdd:COG5278   157 RLLLLALALAALLLAAAALLLLLLALAALLALAELLLLALARALAALLLLLLLEAELAAAAALLAAAAALAALAALELLA 236
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1512 SDLTEQLGETGKSIHELEKSKKAVETEKAEIQTALEEAEGTLEHEESKILRVQLELNQVKSEIDRKLAEKDEEIEQIKRN 1591
Cdd:COG5278   237 ALALALALLLAALLLALLAALALAALLAAALLALAALLLALAAAAALAAAAALELAAAEALALAELELELLLAAAAAAAA 316
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1592 SQRITDSMQSTLDSEVRSRNDALRIKKKMEGDLNEMEIQLSHANRQAAEAQKQLRNVQAQLKDAQLHLDDAVRGQEDMKE 1671
Cdd:COG5278   317 AAAAAAAALAALLALALATALAAAAAALALLAALLAEAAAAAAEEAEAAAEAAAAALAGLAEVEAEGAAEAVELEVLAIA 396
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1672 QVAMVERRNTLMQSEIEELRAALEQTERGRKVAEQELVDASERVGLLHSQNTSLLNTKKKLEADLVQIQSEVEDTVQEAR 1751
Cdd:COG5278   397 AAAAAAAAEAAAAAAAAAAASAAEALELAEALAEALALAEEEALALAAASSELAEAGAALALAAAEALAEELAAVAALAA 476
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 288856329 1752 NAEDKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEVTVKDLQHRLDEAE 1803
Cdd:COG5278   477 LAAAAAALAEAEAAAALAAAAALSLALALAALLLAAAEAALAAALAAALASA 528
EzrA pfam06160
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...
1314-1699 6.43e-04

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.


Pssm-ID: 428797 [Multi-domain]  Cd Length: 542  Bit Score: 44.46  E-value: 6.43e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1314 IEELKRQIEEE------VKAKNALAHA----------VQSARHDCDLLREQFEEEQEAKAELQRGMSKANSEVAQWRTKY 1377
Cdd:pfam06160   65 IEELLFEAEELndkyrfKKAKKALDEIeellddieedIKQILEELDELLESEEKNREEVEELKDKYRELRKTLLANRFSY 144
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1378 ETDAiqrtEELEESKKKLAQRLQEAEEQIEAVNSKCAS--LEKTKQRLqGEVEDLMIDVEranalaANLDKKQRNFDKVL 1455
Cdd:pfam06160  145 GPAI----DELEKQLAEIEEEFSQFEELTESGDYLEARevLEKLEEET-DALEELMEDIP------PLYEELKTELPDQL 213
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1456 AEWKQKYEegQAELEGAQKEARSLSTELFKMKNSYEETLDQLETL-----KRENKNLQQEISDLTEQLgetgksihELE- 1529
Cdd:pfam06160  214 EELKEGYR--EMEEEGYALEHLNVDKEIQQLEEQLEENLALLENLeldeaEEALEEIEERIDQLYDLL--------EKEv 283
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1530 KSKKAVETEKAEIQTALEEAEGTLEHEESKILRVQL-----------------ELNQVK-----------------SEID 1575
Cdd:pfam06160  284 DAKKYVEKNLPEIEDYLEHAEEQNKELKEELERVQQsytlnenelervrglekQLEELEkrydeiverleekevaySELQ 363
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1576 RKLAEKDEEIEQIKRNSQRITDSMQSTLDSEVRSRNDALRIKKKME------------GDLNEMEIQLSHANRQAAEAQK 1643
Cdd:pfam06160  364 EELEEILEQLEEIEEEQEEFKESLQSLRKDELEAREKLDEFKLELReikrlveksnlpGLPESYLDYFFDVSDEIEDLAD 443
                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 288856329  1644 QLRN-------VQAQLKDAQLHLDDAVRGQEDMKEQVAMVERrntLMQ------SEIEELRAALEQTER 1699
Cdd:pfam06160  444 ELNEvplnmdeVNRLLDEAQDDVDTLYEKTEELIDNATLAEQ---LIQyanryrSSNPEVAEALTEAEL 509
PLN02939 PLN02939
transferase, transferring glycosyl groups
1432-1749 6.70e-04

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 44.89  E-value: 6.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1432 IDVERANALAANLDKKQRNFdkvlaewKQKYEEGQAELEGAQKEARSLSTELFKMKNSYEETLDQLETLKRENKNLQQEI 1511
Cdd:PLN02939  100 ASMQRDEAIAAIDNEQQTNS-------KDGEQLSDFQLEDLVGMIQNAEKNILLLNQARLQALEDLEKILTEKEALQGKI 172
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1512 SDLTEQLGETGKSIHELEKSKKAVETEKAEIQTALEEAEGTLEHEESKILRVQLELNQVKSEidrKLAEKDeEIEQIKRN 1591
Cdd:PLN02939  173 NILEMRLSETDARIKLAAQEKIHVEILEEQLEKLRNELLIRGATEGLCVHSLSKELDVLKEE---NMLLKD-DIQFLKAE 248
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1592 SQRITDSMQS--TLDSEvrsrndalriKKKMEGDLNEMEIQLSHANRQAAE-AQKQLRNVQAQLKDAQLHLDDAVrgqeD 1668
Cdd:PLN02939  249 LIEVAETEERvfKLEKE----------RSLLDASLRELESKFIVAQEDVSKlSPLQYDCWWEKVENLQDLLDRAT----N 314
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1669 MKEQVAMVERRNTLMQSEIEELRAALEQTergrKVAEQelvdASERVGLLHSQNTSLlntKKKLEADLVQIQSEV---ED 1745
Cdd:PLN02939  315 QVEKAALVLDQNQDLRDKVDKLEASLKEA----NVSKF----SSYKVELLQQKLKLL---EERLQASDHEIHSYIqlyQE 383

                  ....
gi 288856329 1746 TVQE 1749
Cdd:PLN02939  384 SIKE 387
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
1456-1912 6.76e-04

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 44.96  E-value: 6.76e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1456 AEWKQKYEEGQAELEGAQKEARSLSTELFKMKNSYEETLDQLETLKRENKNLQQEISDLTEQLGETGKSIHELEKSKKAV 1535
Cdd:TIGR00618  183 LMEFAKKKSLHGKAELLTLRSQLLTLCTPCMPDTYHERKQVLEKELKHLREALQQTQQSHAYLTQKREAQEEQLKKQQLL 262
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1536 ETEKAEIQTaleeaegtLEHEESKILRVQLELNQVKSEIdrKLAEKDEEIEQIKRNSQRITDSMQSTLDSEVRSR-NDAL 1614
Cdd:TIGR00618  263 KQLRARIEE--------LRAQEAVLEETQERINRARKAA--PLAAHIKAVTQIEQQAQRIHTELQSKMRSRAKLLmKRAA 332
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1615 RIKKKMEGDLNEMEIQLSHA----NRQAAEAQKQLRNVQAQLKDAQLHLDDAVRGQEDMKEQVAMVERRNTLMQSEI--E 1688
Cdd:TIGR00618  333 HVKQQSSIEEQRRLLQTLHSqeihIRDAHEVATSIREISCQQHTLTQHIHTLQQQKTTLTQKLQSLCKELDILQREQatI 412
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1689 ELRAALEQTERGRKV-AEQELVDASERVGLLHSQNTSLLNTKKKLEADLVQIQSEVEDTVQEARNAEDKAKKAITDAAMM 1767
Cdd:TIGR00618  413 DTRTSAFRDLQGQLAhAKKQQELQQRYAELCAAAITCTAQCEKLEKIHLQESAQSLKEREQQLQTKEQIHLQETRKKAVV 492
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1768 AEELKKEQDTSAHLERMKKNLEVTVKDL------QHRLDEAENLAMKGGKK------QLQKLESRVRELESEVEAEQRRg 1835
Cdd:TIGR00618  493 LARLLELQEEPCPLCGSCIHPNPARQDIdnpgplTRRMQRGEQTYAQLETSeedvyhQLTSERKQRASLKEQMQEIQQS- 571
                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 288856329  1836 adavkgVRKYERRVKELTYQTEEDKKNVNRLQDLVDKLQLKVKAYKRQSEEAEEQANSHLSKLRKVQHELEEAEERA 1912
Cdd:TIGR00618  572 ------FSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHLQQCSQELA 642
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1454-1776 7.08e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 44.12  E-value: 7.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1454 VLAEWKQKYEEGQAELEGAQKEARSLSTELFKMKNSYEETLDQLETLKRENKNLQQEISDLTEQLGETGKSIHELEKSKK 1533
Cdd:COG4372    25 LIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELE 104
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1534 AVETEKAEIQTALEEaegtLEHEESKILRVQLELNQVKSEIDRKLAEKDEEIEQIKRNSQRITDSMQSTLDSEVRSRNDA 1613
Cdd:COG4372   105 SLQEEAEELQEELEE----LQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAE 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1614 LRIKKKMEGDLNEMEIQLSHANRQAAEAQKQLRNVQAQLKDAQLHLDDAVRGQEDMKEQVAMVERRNTLMQSEIEELRAA 1693
Cdd:COG4372   181 AEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEI 260
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1694 LEQTERGRKVAEQELVDASERVGLLHSQNTSLLNTKKKLEADLVQIQSEVEDTVQEARNAEDKAKKAITDAAMMAEELKK 1773
Cdd:COG4372   261 EELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLELAKKLELALAILLAELA 340

                  ...
gi 288856329 1774 EQD 1776
Cdd:COG4372   341 DLL 343
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1238-1566 7.14e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 44.12  E-value: 7.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1238 EAVAKAKANLEKMCRTLEDQLSEIKSKNDENLRQINDLSAQRARLQTENGEFGRQLEEKEALVSQLTRGKQAFTQQIEEL 1317
Cdd:COG4372     6 EKVGKARLSLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEEL 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1318 KRQIEEEVKAKNALAHAVQSARHDCDLLREQFEEEQEAKAELQRGMSKANSEVAQWRTKYeTDAIQRTEELEESKKKLAQ 1397
Cdd:COG4372    86 NEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEI-AEREEELKELEEQLESLQE 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1398 RLQEAEEQIEAVNSKCASLEKTKQRLQGEVEDLMIDVERANALAANLDKKQRNFDKVLAEWKQKYEEGQAELEGAQKEAR 1477
Cdd:COG4372   165 ELAALEQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALEL 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1478 SLSTELFKMKNSYEETLDQLETLKRENKNLQQEISDLTEQLGETGKSIHELEKSKKAVETEKAEIQTALEEAEGTLEHEE 1557
Cdd:COG4372   245 EEDKEELLEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLEL 324

                  ....*....
gi 288856329 1558 SKILRVQLE 1566
Cdd:COG4372   325 AKKLELALA 333
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
1631-1927 7.28e-04

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 44.94  E-value: 7.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1631 LSHANR------QAAEAQKQLRNVQAQLKDAQLHLDDAVRGQEDMKEQVAMVE--------RRNTLM------------Q 1684
Cdd:COG3096   274 MRHANErrelseRALELRRELFGARRQLAEEQYRLVEMARELEELSARESDLEqdyqaasdHLNLVQtalrqqekieryQ 353
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1685 SEIEELRAALEQTERGRKVAEQELVDASERVGLLHSQNTSLlntKKKLeADLVQ---IQSEVEDTVQEARNAEDKAKKAI 1761
Cdd:COG3096   354 EDLEELTERLEEQEEVVEEAAEQLAEAEARLEAAEEEVDSL---KSQL-ADYQQaldVQQTRAIQYQQAVQALEKARALC 429
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1762 TDAAMMAEELKKEQdtsAHLERMKKNLEVTVKDLQHRLDEAEnlamkGGKKQLQKLESRVRELESEVEAEQrrgadAVKG 1841
Cdd:COG3096   430 GLPDLTPENAEDYL---AAFRAKEQQATEEVLELEQKLSVAD-----AARRQFEKAYELVCKIAGEVERSQ-----AWQT 496
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1842 VRKYERRVKELTYQTEEDKKNVNRLQDLVDKLQLKVKAyKRQSEEAEEQANSHLSKLRKVQHELEEAEERADIAESQVNK 1921
Cdd:COG3096   497 ARELLRRYRSQQALAQRLQQLRAQLAELEQRLRQQQNA-ERLLEEFCQRIGQQLDAAEELEELLAELEAQLEELEEQAAE 575

                  ....*.
gi 288856329 1922 LRAKSR 1927
Cdd:COG3096   576 AVEQRS 581
PRK11281 PRK11281
mechanosensitive channel MscK;
923-1326 7.47e-04

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 44.52  E-value: 7.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  923 ETTERLEDEEEINAEL-TAKKRKL-EDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAAQDESIGKLTKEKKA 1000
Cdd:PRK11281   30 ASNGDLPTEADVQAQLdALNKQKLlEAEDKLVQQDLEQTLALLDKIDRQKEETEQLKQQLAQAPAKLRQAQAELEALKDD 109
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1001 LQEAHQQTLDDLqaeedkvntltkSKTKLEQQVDDLEGSLEQEKK-----------LRMDLERAKRKLEGDLKLAQEsIM 1069
Cdd:PRK11281  110 NDEETRETLSTL------------SLRQLESRLAQTLDQLQNAQNdlaeynsqlvsLQTQPERAQAALYANSQRLQQ-IR 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1070 DLENDKQQSEEKLkkkdfeTSQLLSKIEDEQS-LGAQLQKKIKELQARIEELEEEieaeraarakvEKQRADLSrelEEI 1148
Cdd:PRK11281  177 NLLKGGKVGGKAL------RPSQRVLLQAEQAlLNAQNDLQRKSLEGNTQLQDLL-----------QKQRDYLT---ARI 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1149 SeRLEEAggATAAQIEMNKKREAEFQKLRRDLEESTLQHEATAAALRKKQADSVAELGEQI------------DNLqRVK 1216
Cdd:PRK11281  237 Q-RLEHQ--LQLLQEAINSKRLTLSEKTVQEAQSQDEAARIQANPLVAQELEINLQLSQRLlkateklntltqQNL-RVK 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1217 QKLEkekseykmeiddlssnmeavakakaNLEKMCRTLEDQ---------LSEIKSKNDENLRQ---INDLSAQRARL-- 1282
Cdd:PRK11281  313 NWLD-------------------------RLTQSERNIKEQisvlkgsllLSRILYQQQQALPSadlIEGLADRIADLrl 367
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*.
gi 288856329 1283 -QTENGEFGRQLEEKEALVSQLTRG-KQAFTqqiEELKRQIEEEVK 1326
Cdd:PRK11281  368 eQFEINQQRDALFQPDAYIDKLEAGhKSEVT---DEVRDALLQLLD 410
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
843-1057 8.18e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 43.98  E-value: 8.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  843 KSAETEKELATMKEDFVKCKEDLAKAEAKKKELEEKMVALLQEKNDLQLAVASESENLSDAEERCEGLIKSKIQLEAKLK 922
Cdd:COG4942    21 AAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELE 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  923 ETTERL----------------------EDEEEINAELTAKKRKLEdecsELKKDIDDLELTLAKVEKEKHATENKVKNL 980
Cdd:COG4942   101 AQKEELaellralyrlgrqpplalllspEDFLDAVRRLQYLKYLAP----ARREQAEELRADLAELAALRAELEAERAEL 176
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 288856329  981 TEEMAAQDESIGKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKSKTKLEQQVDDLEGSLEQ--EKKLRMDLERAKRKL 1057
Cdd:COG4942   177 EALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAaaERTPAAGFAALKGKL 255
Golgin_A5 pfam09787
Golgin subfamily A member 5; Members of this family of proteins are involved in maintaining ...
1383-1551 9.05e-04

Golgin subfamily A member 5; Members of this family of proteins are involved in maintaining Golgi structure. They stimulate the formation of Golgi stacks and ribbons, and are involved in intra-Golgi retrograde transport. Two main interactions have been characterized: one with RAB1A that has been activated by GTP-binding and another with isoform CASP of CUTL1.


Pssm-ID: 462900 [Multi-domain]  Cd Length: 305  Bit Score: 43.59  E-value: 9.05e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1383 QRTEELEESKKKLAQRLQEA--EEQIEAVNSKCASLEKTKQR----------LQGEVEDL---MIDVE-RANALAANLDK 1446
Cdd:pfam09787   14 QKAARILQSKEKLIASLKEGsgVEGLDSSTALTLELEELRQErdllreeiqkLRGQIQQLrteLQELEaQQQEEAESSRE 93
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1447 KQRNFDKVLAEWKQKYEEGQAELEGAQKEARSLSTELFKMKNSYEETLDQLE----------TLKRENKNLQQEISDLTE 1516
Cdd:pfam09787   94 QLQELEEQLATERSARREAEAELERLQEELRYLEEELRRSKATLQSRIKDREaeieklrnqlTSKSQSSSSQSELENRLH 173
                          170       180       190
                   ....*....|....*....|....*....|....*
gi 288856329  1517 QLGETgksIHELEKSKKAVETEKAEIQTALEEAEG 1551
Cdd:pfam09787  174 QLTET---LIQKQTMLEALSTEKNSLVLQLERMEQ 205
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
882-1019 9.21e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 42.99  E-value: 9.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  882 LLQEKNDLQLAVASESENLSDAEERCEGLIKSKIQLEAKLKETTERLE-DEEEINAELTAKKRK-LEDECSELKKDIDDL 959
Cdd:COG1579    29 LPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKkYEEQLGNVRNNKEYEaLQKEIESLKRRISDL 108
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  960 ELTLAKVEKEKHATENKVKNLTEEMAAQDESIGKLTKEKKALQEAHQQTLDDLQAEEDKV 1019
Cdd:COG1579   109 EDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREEL 168
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
1709-1937 1.07e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 43.67  E-value: 1.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1709 VDASERVGLLHSQNTSLLNTKKKLEADLVQIQSEVEDTVQEARNAEDKAKKAITDAAMMAEELKKEQdtsAHLERMKKNL 1788
Cdd:COG3883    12 AFADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAE---AEIEERREEL 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1789 EVTVKDLQHRLDEAENLAMKGGKKQLQKLESRVRELESEVEAEQRRgadavkgVRKYERRVKELTYQTEEDKKNVNRLQD 1868
Cdd:COG3883    89 GERARALYRSGGSVSYLDVLLGSESFSDFLDRLSALSKIADADADL-------LEELKADKAELEAKKAELEAKLAELEA 161
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 288856329 1869 LVDKLQLKVKAYKRQSEEAEEQANSHLSKLRKVQHELEEAEERADIAESQVNKLRAKSRDSGKGKDAAE 1937
Cdd:COG3883   162 LKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAA 230
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1007-1322 1.09e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 43.85  E-value: 1.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1007 QTLDDLQAEEDKVNT---LTKSKTKLEQQVDDLeGSLEQEKKLRMDLERAKRKLEGDLKLAQE---SIMDLE---NDKQQ 1077
Cdd:COG3206    71 SGLSSLSASDSPLETqieILKSRPVLERVVDKL-NLDEDPLGEEASREAAIERLRKNLTVEPVkgsNVIEISytsPDPEL 149
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1078 SEEKLKK--KDFETSQLLSKIEDEQSLGAQLQKKIKELQARieeleeeieaeraaRAKVEKQRADLSRELEEISerLEEA 1155
Cdd:COG3206   150 AAAVANAlaEAYLEQNLELRREEARKALEFLEEQLPELRKE--------------LEEAEAALEEFRQKNGLVD--LSEE 213
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1156 GGATAAQIemnkkreAEFQKLRRDLEESTLQHEATAAALRKKQADSVAELGEQIDNlqRVKQKLEKEKSEYKMEIDDLSs 1235
Cdd:COG3206   214 AKLLLQQL-------SELESQLAEARAELAEAEARLAALRAQLGSGPDALPELLQS--PVIQQLRAQLAELEAELAELS- 283
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1236 nmeavAKAKANLEKMcRTLEDQLSEIKSKNDENLRQI-NDLSAQRARLQTENGEFGRQLEEKEALVSQLTRgKQaftQQI 1314
Cdd:COG3206   284 -----ARYTPNHPDV-IALRAQIAALRAQLQQEAQRIlASLEAELEALQAREASLQAQLAQLEARLAELPE-LE---AEL 353

                  ....*...
gi 288856329 1315 EELKRQIE 1322
Cdd:COG3206   354 RRLEREVE 361
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
1420-1573 1.10e-03

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 43.47  E-value: 1.10e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   1420 KQRLQGEVEDLMIDVERANALAANLDKKQRNFDKVLAEWKQKYEEGQAELEGAQKEARSL----STELFKMKNsyeetld 1495
Cdd:smart00787  139 MKLLEGLKEGLDENLEGLKEDYKLLMKELELLNSIKPKLRDRKDALEEELRQLKQLEDELedcdPTELDRAKE------- 211
                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 288856329   1496 QLETLKRENKNLQQEISDLTEQLGETGKSIHELEKSKKAVETEKAEIQTALEEAEGtleHEESKILRVQLELNQVKSE 1573
Cdd:smart00787  212 KLKKLLQEIMIKVKKLEELEEELQELESKIEDLTNKKSELNTEIAEAEKKLEQCRG---FTFKEIEKLKEQLKLLQSL 286
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
1492-1929 1.13e-03

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 44.19  E-value: 1.13e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1492 ETLDQLETLKRENKNLQQEISDLTEQLGETGKSIHElekSKKAVETEKAEIQTALEEAEGTLEHeeskiLRVQLELNQVK 1571
Cdd:TIGR00618  184 MEFAKKKSLHGKAELLTLRSQLLTLCTPCMPDTYHE---RKQVLEKELKHLREALQQTQQSHAY-----LTQKREAQEEQ 255
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1572 SEIDRKLAEKDEEIEQIKrnsqritdsmqsTLDSEVRSRNDALRIKKKMEGDLNEMEiQLSHANRQAAEAQKQLRNVQAQ 1651
Cdd:TIGR00618  256 LKKQQLLKQLRARIEELR------------AQEAVLEETQERINRARKAAPLAAHIK-AVTQIEQQAQRIHTELQSKMRS 322
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1652 LKDAQLHLDDAVRGQEDMKEQVAMVerrNTLMQSEIEELRAALEQTERgRKVAEQELVDaSERVGLLHSQNTSLLNTKKK 1731
Cdd:TIGR00618  323 RAKLLMKRAAHVKQQSSIEEQRRLL---QTLHSQEIHIRDAHEVATSI-REISCQQHTL-TQHIHTLQQQKTTLTQKLQS 397
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1732 LEADLVQIQSEVEDtvQEARNAEDKAKKAITDAAMMAEELKKE-----QDTSAHLERMKKNLEVTVKDLQHRLDEAENLa 1806
Cdd:TIGR00618  398 LCKELDILQREQAT--IDTRTSAFRDLQGQLAHAKKQQELQQRyaelcAAAITCTAQCEKLEKIHLQESAQSLKEREQQ- 474
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1807 mKGGKKQLQKLESRVRELESEVEAEQRRGADAVKGVRKYERRVKELTYQTEEDKKNVNRLQDLVDKLQlkvkaykrqseE 1886
Cdd:TIGR00618  475 -LQTKEQIHLQETRKKAVVLARLLELQEEPCPLCGSCIHPNPARQDIDNPGPLTRRMQRGEQTYAQLE-----------T 542
                          410       420       430       440
                   ....*....|....*....|....*....|....*....|...
gi 288856329  1887 AEEQANSHLSKLRKVQHELEEAEERADIAESQVNKLRAKSRDS 1929
Cdd:TIGR00618  543 SEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKED 585
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
1496-1702 1.18e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 42.60  E-value: 1.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1496 QLETLKRENKNLQQEISDLTEQLGEtgksiheLEKSKKAVETEKAEIQTALEEAEGTLEHEESKILRVQLELNQVKSEID 1575
Cdd:COG1579    18 ELDRLEHRLKELPAELAELEDELAA-------LEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVRNNKE 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1576 RKLAEKdeEIEQIKRNsqritdsmqstldsevrsrndalriKKKMEGDLNEMEIQLSHANRQAAEAQKQLRNVQAQLKDA 1655
Cdd:COG1579    91 YEALQK--EIESLKRR-------------------------ISDLEDEILELMERIEELEEELAELEAELAELEAELEEK 143
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 288856329 1656 QLHLDDAVrgQEDMKEQVAMVERRNTLMQSEIEELRAALEQTERGRK 1702
Cdd:COG1579   144 KAELDEEL--AELEAELEELEAEREELAAKIPPELLALYERIRKRKN 188
MutS2 COG1193
dsDNA-specific endonuclease/ATPase MutS2 [Replication, recombination and repair];
1050-1209 1.18e-03

dsDNA-specific endonuclease/ATPase MutS2 [Replication, recombination and repair];


Pssm-ID: 440806 [Multi-domain]  Cd Length: 784  Bit Score: 43.98  E-value: 1.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1050 LERAKRKLEGDLKLAQESIMDLENDKQQSEEKLKkkdfETSQLLSKIEdeqSLGAQLQKKIKELQarieeleeeieaeRA 1129
Cdd:COG1193   502 IERARELLGEESIDVEKLIEELERERRELEEERE----EAERLREELE---KLREELEEKLEELE-------------EE 561
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1130 ARAKVEKQRADLSRELEEISERLEEaggaTAAQIEMNKKREAEFQKLRRDLEEstLQHEATAAALRKKQADSVAELGEQI 1209
Cdd:COG1193   562 KEEILEKAREEAEEILREARKEAEE----LIRELREAQAEEEELKEARKKLEE--LKQELEEKLEKPKKKAKPAKPPEEL 635
46 PHA02562
endonuclease subunit; Provisional
1177-1433 1.20e-03

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 43.85  E-value: 1.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1177 RRDLEESTLQhEATAAALRKKQADSVAELGEQIDNLQRVKQKLEKEKSEYKMEIDDLSsnmeavAKAKANLEkmcrtled 1256
Cdd:PHA02562  152 RRKLVEDLLD-ISVLSEMDKLNKDKIRELNQQIQTLDMKIDHIQQQIKTYNKNIEEQR------KKNGENIA-------- 216
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1257 qlsEIKSKNDENLRQINDLSAQRARLQTENGEFGRQLEEKEALVSQLTRGKQAFTQQIEELKR----------------Q 1320
Cdd:PHA02562  217 ---RKQNKYDELVEEAKTIKAEIEELTDELLNLVMDIEDPSAALNKLNTAAAKIKSKIEQFQKvikmyekggvcptctqQ 293
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1321 IEEEVKAKNALAHAVQSARHDCDLLREQFEEEQEAKAELQRGMSKANsevaQWRTKYETD--AIQRTEELEESKKKLAQR 1398
Cdd:PHA02562  294 ISEGPDRITKIKDKLKELQHSLEKLDTAIDELEEIMDEFNEQSKKLL----ELKNKISTNkqSLITLVDKAKKVKAAIEE 369
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 288856329 1399 LQEA-----------EEQIEAVNSKCASLEKTKQRLqGEVEDLMID 1433
Cdd:PHA02562  370 LQAEfvdnaeelaklQDELDKIVKTKSELVKEKYHR-GIVTDLLKD 414
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
1416-1710 1.29e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 43.57  E-value: 1.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1416 LEKTKQ-RLQGEVEDLMIDVERANALAANLDKKQRNFDK---VLAEWKQKYEEGQAELEGAQKEARslstelfkmknsye 1491
Cdd:pfam17380  293 FEKMEQeRLRQEKEEKAREVERRRKLEEAEKARQAEMDRqaaIYAEQERMAMERERELERIRQEER-------------- 358
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1492 etldqletlKRENKNLQQEisdlteQLGETGKSIHELEKSKKAVETEKAEIQTALEEAEgtleheESKILrvqlelnqvK 1571
Cdd:pfam17380  359 ---------KRELERIRQE------EIAMEISRMRELERLQMERQQKNERVRQELEAAR------KVKIL---------E 408
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1572 SEIDRKLAEKDEEIEQIKRNSQRITDSMQSTLDSEvRSRndalrikkkmegdlnEME-IQLSHANRQaaEAQKQLRNVQA 1650
Cdd:pfam17380  409 EERQRKIQQQKVEMEQIRAEQEEARQREVRRLEEE-RAR---------------EMErVRLEEQERQ--QQVERLRQQEE 470
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1651 QLKDAQLHLDDAVRGQEDMKEQvamverRNTLMQSEIEELRAALEQTERGRKVAEQELVD 1710
Cdd:pfam17380  471 ERKRKKLELEKEKRDRKRAEEQ------RRKILEKELEERKQAMIEEERKRKLLEKEMEE 524
CagA_N pfam18971
CagA protein; The Helicobacter pylori type IV secretion effector CagA is a major bacterial ...
884-1091 1.31e-03

CagA protein; The Helicobacter pylori type IV secretion effector CagA is a major bacterial virulence determinant and critical for gastric carcinogenesis. X-ray crystallographic analysis of the N-terminal CagA fragment (residues 1-876) revealed that the region has a structure comprised of three discrete domains. Domain I constitutes a mobile CagA N terminus, while Domain II tethers CagA to the plasma membrane by interacting with membrane phosphatidylserine. Domain III interacts intramolecularly with the intrinsically disordered C-terminal region, and this interaction potentiates the pathogenic scaffold/hub function of CagA.


Pssm-ID: 408741 [Multi-domain]  Cd Length: 876  Bit Score: 43.99  E-value: 1.31e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   884 QEKNDLQLAVASESENLSDAEERCEGLIKSKIQLEAKLKETTERLEDEEEINAE-------------LTAKKRKLEDECS 950
Cdd:pfam18971  614 KAQKDLEKSLRKREHLEKEVEKKLESKSGNKNKMEAKAQANSQKDEIFALINKEanrdaraiaytqnLKGIKRELSDKLE 693
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329   951 ELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAAQDESIGkLTKEKKALQEAHQQTLDDLQAEEDK-VNTLTKSKTKL 1029
Cdd:pfam18971  694 KISKDLKDFSKSFDEFKNGKNKDFSKAEETLKALKGSVKDLG-INPEWISKVENLNAALNEFKNGKNKdFSKVTQAKSDL 772
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 288856329  1030 EQQVDDLEGSLEQEKKL-RMDLERAKRKLEGDLKLAQESIMDLEN--DKQQSEEKLKKKDFETSQ 1091
Cdd:pfam18971  773 ENSVKDVIINQKVTDKVdNLNQAVSVAKAMGDFSRVEQVLADLKNfsKEQLAQQAQKNEDFNTGK 837
PRK12704 PRK12704
phosphodiesterase; Provisional
1022-1182 1.36e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 43.61  E-value: 1.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1022 LTKSKTKLEQQVDDLEGSLEQEKKLRM-----DLERAKRKLEGDLKLAQESIMDLENDKQQSEEKLKKKdfetSQLLSKI 1096
Cdd:PRK12704   33 IKEAEEEAKRILEEAKKEAEAIKKEALleakeEIHKLRNEFEKELRERRNELQKLEKRLLQKEENLDRK----LELLEKR 108
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1097 EDEqslgaqLQKKIKELQARIEEleeeieaeraarakVEKQRADLSRELEEISERLEEAGGATAAQI------EMNKKRE 1170
Cdd:PRK12704  109 EEE------LEKKEKELEQKQQE--------------LEKKEEELEELIEEQLQELERISGLTAEEAkeilleKVEEEAR 168
                         170
                  ....*....|..
gi 288856329 1171 AEFQKLRRDLEE 1182
Cdd:PRK12704  169 HEAAVLIKEIEE 180
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
1091-1242 1.61e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 42.22  E-value: 1.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1091 QLLSKIEDEQSLGAQLQKKIKELQARIEELEEEIEAERAARAKVEKQRADLSRELEEISERLEEA----GGATAAQIEMN 1166
Cdd:COG1579    14 ELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYeeqlGNVRNNKEYEA 93
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 288856329 1167 KKREAEFQKLRR-DLEESTLQHEATAAALRKKQADSVAELGEQIDNLQRVKQKLEKEKSEYKMEIDDLSSNMEAVAK 1242
Cdd:COG1579    94 LQKEIESLKRRIsDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREELAA 170
PLN03188 PLN03188
kinesin-12 family protein; Provisional
1767-1925 1.65e-03

kinesin-12 family protein; Provisional


Pssm-ID: 215621 [Multi-domain]  Cd Length: 1320  Bit Score: 43.77  E-value: 1.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1767 MAEELKKEQDTSAHL-ERMKKNLEvTVKDLQHRLDEAENLAMKGGKKQLQKLeSRVRELESEVEAEQRR---GADAVK-- 1840
Cdd:PLN03188 1066 LAEELRTELDASRALaEKQKHELD-TEKRCAEELKEAMQMAMEGHARMLEQY-ADLEEKHIQLLARHRRiqeGIDDVKka 1143
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1841 ----GVRKYERR-----VKELTYQTEEDKKNVNRLQDLVDKLQLKVkaykRQSEEAEEQANSHLSKLRKVQHELEEAEER 1911
Cdd:PLN03188 1144 aaraGVRGAESKfinalAAEISALKVEREKERRYLRDENKSLQAQL----RDTAEAVQAAGELLVRLKEAEEALTVAQKR 1219
                         170       180
                  ....*....|....*....|.
gi 288856329 1912 ADIAE-------SQVNKLRAK 1925
Cdd:PLN03188 1220 AMDAEqeaaeayKQIDKLKRK 1240
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
1308-1485 1.69e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 42.22  E-value: 1.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1308 QAFTQQIEELKRQIEEevkaknaLAHAVQSARHDCDLLREQFEEEQEAKAELQRGMSKANSEVAQWRTKyetdaiqrtee 1387
Cdd:COG1579    13 QELDSELDRLEHRLKE-------LPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEAR----------- 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1388 LEESKKKLAQrlQEAEEQIEAVNSKCASLEKTKQRLQGEVEDLMIDVERANALAANLDKKQRNFDKVLAEWKQKYEEGQA 1467
Cdd:COG1579    75 IKKYEEQLGN--VRNNKEYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELA 152
                         170
                  ....*....|....*...
gi 288856329 1468 ELEGAQKEARSLSTELFK 1485
Cdd:COG1579   153 ELEAELEELEAEREELAA 170
PLN02939 PLN02939
transferase, transferring glycosyl groups
1522-1837 1.83e-03

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 43.35  E-value: 1.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1522 GKSIHELEKSKKAVETEKAEIQTALEEAEGTLEHEESKILRVQLELNQ-----------VKSEIDRKLAEKDEEIEQIKR 1590
Cdd:PLN02939   41 GFSSQQKKKRGKNIAPKQRSSNSKLQSNTDENGQLENTSLRTVMELPQkstssdddhnrASMQRDEAIAAIDNEQQTNSK 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1591 NSQRITD-----------SMQSTL----DSEVRSRNDALRI---KKKMEGDLNEMEIQLSHANRQAAEAQKQlrNVQAQL 1652
Cdd:PLN02939  121 DGEQLSDfqledlvgmiqNAEKNIlllnQARLQALEDLEKIlteKEALQGKINILEMRLSETDARIKLAAQE--KIHVEI 198
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1653 KDAQLHL---DDAVRGQED------MKEQVAMVERRNTLMQSEIEELRAALEqtergrkvaeqELVDASERVGLLHSQNT 1723
Cdd:PLN02939  199 LEEQLEKlrnELLIRGATEglcvhsLSKELDVLKEENMLLKDDIQFLKAELI-----------EVAETEERVFKLEKERS 267
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1724 SLLNTKKKLEADLVQIQSEVE-----------DTVQEARNAEDKAKKAITDAAMMaeeLKKEQDTSAHLERMKKNLEVT- 1791
Cdd:PLN02939  268 LLDASLRELESKFIVAQEDVSklsplqydcwwEKVENLQDLLDRATNQVEKAALV---LDQNQDLRDKVDKLEASLKEAn 344
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 288856329 1792 --------VKDLQHRLDEAENLAMKGGKK---QLQKLESRVRE----LESEVEAEQRRGAD 1837
Cdd:PLN02939  345 vskfssykVELLQQKLKLLEERLQASDHEihsYIQLYQESIKEfqdtLSKLKEESKKRSLE 405
PRK11281 PRK11281
mechanosensitive channel MscK;
1380-1687 2.02e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 43.36  E-value: 2.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1380 DAIQRTEELEESKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQGEVEDLMIDVERANAL-AANLDKKQRNFDKV-LAE 1457
Cdd:PRK11281   46 DALNKQKLLEAEDKLVQQDLEQTLALLDKIDRQKEETEQLKQQLAQAPAKLRQAQAELEALkDDNDEETRETLSTLsLRQ 125
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1458 WKQKYEEGQAELEGAQKEARSLSTELFKMKNSYEETLDQLETlkrenkNLQ--QEISDLTEQLGETGKSIHELEKSKKAV 1535
Cdd:PRK11281  126 LESRLAQTLDQLQNAQNDLAEYNSQLVSLQTQPERAQAALYA------NSQrlQQIRNLLKGGKVGGKALRPSQRVLLQA 199
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1536 ETEKAEIQTALEEAE----------GTLEHEES--KILRVQLELNQVKSEIDRKLAEKDEEIEQIKRNSQRITDSMQSTL 1603
Cdd:PRK11281  200 EQALLNAQNDLQRKSlegntqlqdlLQKQRDYLtaRIQRLEHQLQLLQEAINSKRLTLSEKTVQEAQSQDEAARIQANPL 279
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1604 dsevrsrndalrIKKkmEGDLNemeIQLSHANRQAAEAQKQLrnVQAQLKDAQLhLDDAVRGQEDMKEQVAMVerRNTLM 1683
Cdd:PRK11281  280 ------------VAQ--ELEIN---LQLSQRLLKATEKLNTL--TQQNLRVKNW-LDRLTQSERNIKEQISVL--KGSLL 337

                  ....
gi 288856329 1684 QSEI 1687
Cdd:PRK11281  338 LSRI 341
PRK12704 PRK12704
phosphodiesterase; Provisional
1143-1336 2.33e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 42.84  E-value: 2.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1143 RELEEISERLEEAGGATAAQIEMNKKREA--EFQKLRRDLEESTLQHEATAAALRKKqadsvaeLGEQIDNLQRVKQKLE 1220
Cdd:PRK12704   34 KEAEEEAKRILEEAKKEAEAIKKEALLEAkeEIHKLRNEFEKELRERRNELQKLEKR-------LLQKEENLDRKLELLE 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1221 KEKSEYKMEIDDLSSNMEAVAKAKANLEKMCRTLEDQLSEIkskndenlrqindlsaqrARLQTEngefgrqlEEKEALV 1300
Cdd:PRK12704  107 KREEELEKKEKELEQKQQELEKKEEELEELIEEQLQELERI------------------SGLTAE--------EAKEILL 160
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 288856329 1301 SQLtrgKQAFTQQIEELKRQIEEEVK------AKNALAHAVQ 1336
Cdd:PRK12704  161 EKV---EEEARHEAAVLIKEIEEEAKeeadkkAKEILAQAIQ 199
PLN03229 PLN03229
acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional
886-1098 2.59e-03

acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional


Pssm-ID: 178768 [Multi-domain]  Cd Length: 762  Bit Score: 42.92  E-value: 2.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  886 KNDLQ-LAVASESENLSDAEERCEGLiksKIQLEAKLKETTERLEDEEEINAeltakkRKLEDECSELKKDIDDLELTLA 964
Cdd:PLN03229  534 KYKLDmLNEFSRAKALSEKKSKAEKL---KAEINKKFKEVMDRPEIKEKMEA------LKAEVASSGASSGDELDDDLKE 604
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  965 KVEKEKHATENKVKNLTEEMAAQDESIgkltkEKKALQEAHQQTLDDLQAEEDKVNTLTKSKTKLEQQVDDLEGSLEQEK 1044
Cdd:PLN03229  605 KVEKMKKEIELELAGVLKSMGLEVIGV-----TKKNKDTAEQTPPPNLQEKIESLNEEINKKIERVIRSSDLKSKIELLK 679
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 288856329 1045 klrmdLERAKRKLEGDLKLAQEsimdLENDKQQSEEKLKKKdFETSQLLSKIED 1098
Cdd:PLN03229  680 -----LEVAKASKTPDVTEKEK----IEALEQQIKQKIAEA-LNSSELKEKFEE 723
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
910-1045 2.83e-03

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 41.93  E-value: 2.83e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329    910 LIKSKIQLEAK----------LKETTERLEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL-AKVEKEKHATENKVK 978
Cdd:smart00787  121 LVKTFARLEAKkmwyewrmklLEGLKEGLDENLEGLKEDYKLLMKELELLNSIKPKLRDRKDALeEELRQLKQLEDELED 200
                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 288856329    979 NLTEEMAAQDESIGKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKSKTKLEQQVDDLEGSLEQEKK 1045
Cdd:smart00787  201 CDPTELDRAKEKLKKLLQEIMIKVKKLEELEEELQELESKIEDLTNKKSELNTEIAEAEKKLEQCRG 267
PTZ00440 PTZ00440
reticulocyte binding protein 2-like protein; Provisional
908-1628 3.23e-03

reticulocyte binding protein 2-like protein; Provisional


Pssm-ID: 240419 [Multi-domain]  Cd Length: 2722  Bit Score: 42.90  E-value: 3.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  908 EGLIKSKIQLEAKLKETTERLEDEEEINAELTAK-KRKLEDECSELKKDIDDLELTLAKVEKEKhaTENKVKNLTEEMAA 986
Cdd:PTZ00440  900 EHLLNNKIDLKNKLEQHMKIINTDNIIQKNEKLNlLNNLNKEKEKIEKQLSDTKINNLKMQIEK--TLEYYDKSKENING 977
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  987 QDESIGKLTKEKKALQEAHQQTLDDL----QAEEDKVNTL-TKSKTKLEQQVDDLEGSLEQEKKLRMD-----LERAKRK 1056
Cdd:PTZ00440  978 NDGTHLEKLDKEKDEWEHFKSEIDKLnvnyNILNKKIDDLiKKQHDDIIELIDKLIKEKGKEIEEKVDqyislLEKMKTK 1057
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1057 LEgdLKLAQESIMDLENDKQQSEEKLKKKDFETsqLLSKIEDEQSLGAQLQKKIKE----LQARIEELEEEIEAERAARA 1132
Cdd:PTZ00440 1058 LS--SFHFNIDIKKYKNPKIKEEIKLLEEKVEA--LLKKIDENKNKLIEIKNKSHEhvvnADKEKNKQTEHYNKKKKSLE 1133
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1133 KVEKQRADLSRELEEISERLEEAGGATAAQIEmnkkreaeFQKLRRDLEESTLQHEATAAALRKKQADSVAELGEQIDN- 1211
Cdd:PTZ00440 1134 KIYKQMEKTLKELENMNLEDITLNEVNEIEIE--------YERILIDHIVEQINNEAKKSKTIMEEIESYKKDIDQVKKn 1205
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1212 --LQRVKQKLEKEKSEYKMEIDDLSSNMEA-VAKAKANLEKMCRTLE-DQLSEIKSKNDENLRQI--NDLSAQRARLQTE 1285
Cdd:PTZ00440 1206 msKERNDHLTTFEYNAYYDKATASYENIEElTTEAKGLKGEANRSTNvDELKEIKLQVFSYLQQVikENNKMENALHEIK 1285
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1286 NGEFGRQLEEKEALVSQLTRGkqafTQQIEELKRQIEEEVKAKNALAHAVqsarhdcdllreqfeEEQEAKAELQRGMSK 1365
Cdd:PTZ00440 1286 NMYEFLISIDSEKILKEILNS----TKKAEEFSNDAKKELEKTDNLIKQV---------------EAKIEQAKEHKNKIY 1346
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1366 ANSEVAQWRTKYETdAIQRTEELEESKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRlqgevedlmIDVERANALAANLD 1445
Cdd:PTZ00440 1347 GSLEDKQIDDEIKK-IEQIKEEISNKRKEINKYLSNIKSNKEKCDLHVRNASRGKDK---------IDFLNKHEAIEPSN 1416
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1446 KKQRNFDKVlAEWKQKYEEGQAELEGAQKEARSLSTELFKMKNSYEETLDQLETLKRENK--NLQQEISDLTEQLGETGK 1523
Cdd:PTZ00440 1417 SKEVNIIKI-TDNINKCKQYSNEAMETENKADENNDSIIKYEKEITNILNNSSILGKKTKleKKKKEATNIMDDINGEHS 1495
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1524 SIHE-LEKSKKAVETEKAeiQTALEEAEGTLEHEESKILRVQLELN--QVKSEIdrklaekdEEIEQIKRNSQRI----T 1596
Cdd:PTZ00440 1496 IIKTkLTKSSEKLNQLNE--QPNIKREGDVLNNDKSTIAYETIQYNlgRVKHNL--------LNILNIKDEIETIlnkaQ 1565
                         730       740       750
                  ....*....|....*....|....*....|...
gi 288856329 1597 DSMQSTLD-SEVRSRNDALRIKKKMEGDLNEME 1628
Cdd:PTZ00440 1566 DLMRDISKiSKIVENKNLENLNDKEADYVKYLD 1598
RecN COG0497
DNA repair ATPase RecN [Replication, recombination and repair];
1288-1550 3.27e-03

DNA repair ATPase RecN [Replication, recombination and repair];


Pssm-ID: 440263 [Multi-domain]  Cd Length: 555  Bit Score: 42.37  E-value: 3.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1288 EFGRQLEEKEALvsqltrgKQAFtQQIEELKRQIEEevkaknaLAHAVQSARHDCDLLREQFEEEQEAkaELQRGmskan 1367
Cdd:COG0497   149 AFAGLEELLEEY-------REAY-RAWRALKKELEE-------LRADEAERARELDLLRFQLEELEAA--ALQPG----- 206
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1368 sEVAQWRTKYET--------DAIQRT-EELEESKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQG---EVEDLMIDVE 1435
Cdd:COG0497   207 -EEEELEEERRRlsnaeklrEALQEAlEALSGGEGGALDLLGQALRALERLAEYDPSLAELAERLESaliELEEAASELR 285
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1436 RanaLAANLDkkqrnFD-KVLAEWkqkyEEGQAELEGAQKEARSLSTELFKMKNSYEETLDQLETLKRENKNLQQEISDL 1514
Cdd:COG0497   286 R---YLDSLE-----FDpERLEEV----EERLALLRRLARKYGVTVEELLAYAEELRAELAELENSDERLEELEAELAEA 353
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 288856329 1515 TEQLGETGKSIHEL-----EKSKKAVETE-------KAEIQTALEEAE 1550
Cdd:COG0497   354 EAELLEAAEKLSAArkkaaKKLEKAVTAEladlgmpNARFEVEVTPLE 401
TTKRSYEDQ pfam10212
Predicted coiled-coil domain-containing protein; This is the C-terminal 500 amino acids of a ...
1390-1593 3.35e-03

Predicted coiled-coil domain-containing protein; This is the C-terminal 500 amino acids of a family of proteins with a predicted coiled-coil domain conserved from nematodes to humans. It carries a characteriztic TTKRSYEDQ sequence-motif. The function is not known.


Pssm-ID: 463001  Cd Length: 523  Bit Score: 42.12  E-value: 3.35e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1390 ESKKKLAQRLQEAEEQIeavnskcASLEKTKQRLQGEVEDLMIDVERANALAANLDKKQRNFDKVLAEWKQKYEEGQAEL 1469
Cdd:pfam10212  302 ESREGLAQQVQQSQEKI-------AKLEQEKEHWMLEAQLLKIKLEKENQRIADLEKQLLKGSTSGQLPELVQSKATLPL 374
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1470 EGAQKEARS--------LSTELFKMKNSYEETLDQLETLKREN---KNLQQEISDLTEQLGET-GKSIH----------E 1527
Cdd:pfam10212  375 TAKQGSEASsisekeptPSTSLIGMLTVTTDSEESSDEESREQlikSHYMARIAELTSQLQLAdSKAVHfhaecralakR 454
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1528 LEKSKKAVETEKAEIQTAleeaegtleheESKILRVQLELNQVKSE--------------IDRKLAEKDEEIEQIKRNSQ 1593
Cdd:pfam10212  455 LALAEKSKESLTEELKLA-----------NQNISRLQDELTTTKRSyedqlsmmsdhlcsMNETLTKQREEIDTLKMASK 523
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
1208-1339 3.57e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 41.06  E-value: 3.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1208 QIDNLQRVKQKLEKEKSEYKMEIDDLSSNMEAVAKAKANLEKMCRTLEDQLSEIKSKNDEN----------------LRQ 1271
Cdd:COG1579    18 ELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYeeqlgnvrnnkeyealQKE 97
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 288856329 1272 INDLSAQRARLQTENGEFGRQLEEKEALVSQLTRGKQAFTQQIEELKRQIEEEVKAKNALAHAVQSAR 1339
Cdd:COG1579    98 IESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAER 165
PRK12704 PRK12704
phosphodiesterase; Provisional
1451-1588 3.57e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 42.07  E-value: 3.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1451 FDKVLAEWKQKYEEGQAE--LEGAQKEARSLSTElfKMKNSYEETLDQLETLKRENKNLQQEISDLTEQLgetgksihel 1528
Cdd:PRK12704   24 VRKKIAEAKIKEAEEEAKriLEEAKKEAEAIKKE--ALLEAKEEIHKLRNEFEKELRERRNELQKLEKRL---------- 91
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1529 eKSKKAVETEKAEiqtALEEAEGTLEHEESKILRVQLELNQVKSEIDRKLAEKDEEIEQI 1588
Cdd:PRK12704   92 -LQKEENLDRKLE---LLEKREEELEKKEKELEQKQQELEKKEEELEELIEEQLQELERI 147
Filament pfam00038
Intermediate filament protein;
1682-1924 3.71e-03

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 41.44  E-value: 3.71e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1682 LMQSEIEELRAALEQTERGRKVAEQELVDASERVGLLHSQNTSLLNTKKKLEADLVQIQSEVedtvqearnaeDKAKKAI 1761
Cdd:pfam00038   51 LYEKEIEDLRRQLDTLTVERARLQLELDNLRLAAEDFRQKYEDELNLRTSAENDLVGLRKDL-----------DEATLAR 119
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1762 TDAAMMAEELKKEqdtsahLERMKKNLEVTVKDLQHRL-DEAENLAMKGGKKQlqKLESRVRELESEVEAEQRRgadavk 1840
Cdd:pfam00038  120 VDLEAKIESLKEE------LAFLKKNHEEEVRELQAQVsDTQVNVEMDAARKL--DLTSALAEIRAQYEEIAAK------ 185
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1841 gvrkyERRVKELTYQT--EEDKKNVNRLQDLVDKLQLKVKAYKRQSEEAEEQANSHLSKLRKVQHELEEAEERADIAESQ 1918
Cdd:pfam00038  186 -----NREEAEEWYQSklEELQQAAARNGDALRSAKEEITELRRTIQSLEIELQSLKKQKASLERQLAETEERYELQLAD 260

                   ....*.
gi 288856329  1919 VNKLRA 1924
Cdd:pfam00038  261 YQELIS 266
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
893-1008 3.84e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 42.12  E-value: 3.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  893 VASESENLsdaEERCEGLIKSKIQLEAKLKETTERLEDEEEINAELTAKKRKLEDecsELKKDIDDLELTLAK-VEKEKH 971
Cdd:PRK00409  511 IGEDKEKL---NELIASLEELERELEQKAEEAEALLKEAEKLKEELEEKKEKLQE---EEDKLLEEAEKEAQQaIKEAKK 584
                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 288856329  972 ATENKVKNLTEEMAAQDESIG--KLTKEKKALQEAHQQT 1008
Cdd:PRK00409  585 EADEIIKELRQLQKGGYASVKahELIEARKRLNKANEKK 623
FPP pfam05911
Filament-like plant protein, long coiled-coil; FPP is a family of long coiled-coil plant ...
1386-1542 3.90e-03

Filament-like plant protein, long coiled-coil; FPP is a family of long coiled-coil plant proteins that are filament-like. It interacts with the nuclear envelope-associated protein, MAF1, the WPP family pfam13943.


Pssm-ID: 461778 [Multi-domain]  Cd Length: 859  Bit Score: 42.35  E-value: 3.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1386 EELEESKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQGEVEDLmidvERANALAANLDKKQRNFDKVLAEWKQKYEeg 1465
Cdd:pfam05911  691 EQLKSEKENLEVELASCTENLESTKSQLQESEQLIAELRSELASL----KESNSLAETQLKCMAESYEDLETRLTELE-- 764
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1466 qAELEGAQKEARSLSTELFKMKNSYEETL-------DQLETLKR----------ENKNLQQ--EISDLTEQLGETGKSIH 1526
Cdd:pfam05911  765 -AELNELRQKFEALEVELEEEKNCHEELEakclelqEQLERNEKkessncdadqEDKKLQQekEITAASEKLAECQETIL 843
                          170
                   ....*....|....*.
gi 288856329  1527 ELEKSKKAVETEKAEI 1542
Cdd:pfam05911  844 NLGKQLKALASPQDAS 859
46 PHA02562
endonuclease subunit; Provisional
1723-1878 3.91e-03

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 41.92  E-value: 3.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1723 TSLLNTKKKLEADLVQIQSEVEDTVQEARNAEDKAKK---AITDAAMMAEELKKE--------------QDTSAHLERMK 1785
Cdd:PHA02562  223 DELVEEAKTIKAEIEELTDELLNLVMDIEDPSAALNKlntAAAKIKSKIEQFQKVikmyekggvcptctQQISEGPDRIT 302
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1786 KNLEvTVKDLQHRLDEAENLAMKGGKK--QLQKLESRVRELESEVEAEQRRGADAVKGVRKYERRVKELTYQ----TEED 1859
Cdd:PHA02562  303 KIKD-KLKELQHSLEKLDTAIDELEEImdEFNEQSKKLLELKNKISTNKQSLITLVDKAKKVKAAIEELQAEfvdnAEEL 381
                         170
                  ....*....|....*....
gi 288856329 1860 KKNVNRLQDLVDKLQLKVK 1878
Cdd:PHA02562  382 AKLQDELDKIVKTKSELVK 400
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
1794-1925 4.01e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 41.06  E-value: 4.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1794 DLQHRLDEAENLA--MKGGKKQLQKLESRVRELESEVEAEQRRGADAVKGVRKYERRVKELTYQTEEDKKNVNRLQDL-- 1869
Cdd:COG1579    11 DLQELDSELDRLEhrLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVRNNke 90
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 288856329 1870 VDKLQLKVKAYKRQSEEAEEQANSHLSKLRKVQHELEEAEERADIAESQVNKLRAK 1925
Cdd:COG1579    91 YEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAE 146
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
1639-1831 4.12e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 41.06  E-value: 4.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1639 AEAQKQLRNVQAQLkdaqLHLDDAVRGQEDMKEQVAMVERRNTLMQSEIEELRAALEQTERGRKVAEQELVDASERVgll 1718
Cdd:COG1579     3 PEDLRALLDLQELD----SELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARI--- 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1719 hSQNTSLLNTKKKLEaDLVQIQSEVEDTVQEARNAEDKAKKAITDAAMMAEELKKEQdtsAHLERMKKNLEVTVKDLQHR 1798
Cdd:COG1579    76 -KKYEEQLGNVRNNK-EYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELE---AELAELEAELEEKKAELDEE 150
                         170       180       190
                  ....*....|....*....|....*....|...
gi 288856329 1799 LDEAEnlamkggkKQLQKLESRVRELESEVEAE 1831
Cdd:COG1579   151 LAELE--------AELEELEAEREELAAKIPPE 175
growth_prot_Scy NF041483
polarized growth protein Scy;
1002-1913 4.15e-03

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 42.12  E-value: 4.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1002 QEAHQQTLDDLQAEEDKVNTLTKSKTKLEQQVDDLEGSLEQekkLRMDLERAKRklegdlKLAQESIMDLENDKQQSEEK 1081
Cdd:NF041483    7 QESHRADDDHLSRFEAEMDRLKTEREKAVQHAEDLGYQVEV---LRAKLHEARR------SLASRPAYDGADIGYQAEQL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1082 LKKKDFETSQLLSKIEDE-QSLGAQLQKKIKElqarieELEEEIEAERAARAKVEKQRADLSRELEEISERLEEAGGATA 1160
Cdd:NF041483   78 LRNAQIQADQLRADAERElRDARAQTQRILQE------HAEHQARLQAELHTEAVQRRQQLDQELAERRQTVESHVNENV 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1161 AQIEMNKKREAefQKLRRDLEESTLQHEATAAALRkKQADSVAElgeqidnlqRVKQKLEKEKSEYKMEIDDLssnmeaV 1240
Cdd:NF041483  152 AWAEQLRARTE--SQARRLLDESRAEAEQALAAAR-AEAERLAE---------EARQRLGSEAESARAEAEAI------L 213
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1241 AKAKANLEKMCRTLEDQLSEIKSkNDENLRQINDLSAQRARLQTenGEFGRQLEEKEALVSQLTRGKQAftqQIEELKRQ 1320
Cdd:NF041483  214 RRARKDAERLLNAASTQAQEATD-HAEQLRSSTAAESDQARRQA--AELSRAAEQRMQEAEEALREARA---EAEKVVAE 287
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1321 IEEEVKAKNALAHAVQSAR------HDCDLLREQFEEEQEAKAELQRGMSKANSEVAQWRTKYETDAiqRTEELEESKKK 1394
Cdd:NF041483  288 AKEAAAKQLASAESANEQRtrtakeEIARLVGEATKEAEALKAEAEQALADARAEAEKLVAEAAEKA--RTVAAEDTAAQ 365
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1395 LAQRLQEAEEQIEAVN------SKCASLEKTKQRLQGEVEdlmidVERANALAANLDkkqrnfDKVLAEWKQKYEEGQAE 1468
Cdd:NF041483  366 LAKAARTAEEVLTKASedakatTRAAAEEAERIRREAEAE-----ADRLRGEAADQA------EQLKGAAKDDTKEYRAK 434
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1469 LEGAQKEARSLSTELFKMKnsyEETLDQLETLKRENKNlqqeisDLTEQLGETGKSIHELEKSKKAVETEKAEIQTALEE 1548
Cdd:NF041483  435 TVELQEEARRLRGEAEQLR---AEAVAEGERIRGEARR------EAVQQIEEAARTAEELLTKAKADADELRSTATAESE 505
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1549 AEGTLEHEESKILRVQLE--LNQVKSEIDRKLAEKDEEIEQIKRNSQRitdsmqstldSEVRSRNDALRikkkmegdlne 1626
Cdd:NF041483  506 RVRTEAIERATTLRRQAEetLERTRAEAERLRAEAEEQAEEVRAAAER----------AARELREETER----------- 564
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1627 meiqlSHANRQAAEAqkqlrnvqaqlkdaqlhlDDAVRGQEDMKEQVAMVERRNTLMQSEIEELR-AALEQTERGRkvae 1705
Cdd:NF041483  565 -----AIAARQAEAA------------------EELTRLHTEAEERLTAAEEALADARAEAERIRrEAAEETERLR---- 617
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1706 qelVDASERVGLLHSQntsllntkkkLEADLVQIQSEVEDTVQEAR-NAEDKAKKAITDAAMMAEELKKE-QDTS----- 1778
Cdd:NF041483  618 ---TEAAERIRTLQAQ----------AEQEAERLRTEAAADASAARaEGENVAVRLRSEAAAEAERLKSEaQESAdrvra 684
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1779 ---AHLERM----KKNLEVTVKDLQHRLDEAENLaMKGGKKQLQKLESRVRELESEVEAEQRR-----GADAVKGVRKYE 1846
Cdd:NF041483  685 eaaAAAERVgteaAEALAAAQEEAARRRREAEET-LGSARAEADQERERAREQSEELLASARKrveeaQAEAQRLVEEAD 763
                         890       900       910       920       930       940       950
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 288856329 1847 RRVKELTYQTEEDKKNVnrlQDLVDKLQlkvkaykrqseeaeEQANSHLSKLRK-VQHELE----EAEERAD 1913
Cdd:NF041483  764 RRATELVSAAEQTAQQV---RDSVAGLQ--------------EQAEEEIAGLRSaAEHAAErtrtEAQEEAD 818
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
1441-1931 4.43e-03

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 42.02  E-value: 4.43e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1441 AANLDKKQRNFDKVLAEWKQKYEEGQAELEGAQKEARSLSTELFKMKNSYEETLDQLETLKRENKNLQQEISDLTEQLGE 1520
Cdd:pfam05483   87 AEKIKKWKVSIEAELKQKENKLQENRKIIEAQRKAIQELQFENEKVSLKLEEEIQENKDLIKENNATRHLCNLLKETCAR 166
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1521 TGKSIHELEKSKKAVETEKAEIQTALEEAEGTLEHeeskiLRVQLElnQVKSEIDRKLAEKDEEIEQIKRNSQRitdsmq 1600
Cdd:pfam05483  167 SAEKTKKYEYEREETRQVYMDLNNNIEKMILAFEE-----LRVQAE--NARLEMHFKLKEDHEKIQHLEEEYKK------ 233
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1601 stldsevrsrndalrikkkmegDLNEMEIQLSHANRQAAEAQKQLRNVQAQLKDAQLHLDDAVRGQEDMKEQVAMVERRN 1680
Cdd:pfam05483  234 ----------------------EINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKANQLEEKTKLQDENLKELIEKK 291
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1681 TLMQSEIEELRAALEQTERGRKVAEQELVDASERVGLLHSQNTSLLNTKKKLEADLVQIQSEVEDTV----QEARNAEDK 1756
Cdd:pfam05483  292 DHLTKELEDIKMSLQRSMSTQKALEEDLQIATKTICQLTEEKEAQMEELNKAKAAHSFVVTEFEATTcsleELLRTEQQR 371
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1757 AKKAITDAAMMAEELKKEQDTSAHLERMKKNLEVTVKDLQHRLDEAENL------------AMKGGKKQL---------- 1814
Cdd:pfam05483  372 LEKNEDQLKIITMELQKKSSELEEMTKFKNNKEVELEELKKILAEDEKLldekkqfekiaeELKGKEQELifllqareke 451
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1815 ---------------QKLESRVRELESEVEAEQ---------------------RRGADAVKGVRKYERRVKELTYQTEE 1858
Cdd:pfam05483  452 ihdleiqltaiktseEHYLKEVEDLKTELEKEKlknieltahcdklllenkeltQEASDMTLELKKHQEDIINCKKQEER 531
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 288856329  1859 DKKNVNRLQD----LVDKLQLKVKAYKRQSEEAEEQANSHLSKLRKVQHELEEAEERADIAESQVNKLRAKSRDSGK 1931
Cdd:pfam05483  532 MLKQIENLEEkemnLRDELESVREEFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKCNNLKKQIENKNK 608
PRK12704 PRK12704
phosphodiesterase; Provisional
1751-1913 4.50e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 41.69  E-value: 4.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1751 RNAEDKAKKAITDAAMMAEELKKEqdtsahLERMKKNLEVTVKDLQHRL-DEAENlAMKGGKKQLQKLESRVRELESEVE 1829
Cdd:PRK12704   27 KIAEAKIKEAEEEAKRILEEAKKE------AEAIKKEALLEAKEEIHKLrNEFEK-ELRERRNELQKLEKRLLQKEENLD 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1830 AEQRRgadavkgVRKYERRVKELTYQTEEDKKNVNRLQDLVDKLQLK-VKAYKR----QSEEAEEQAnshLSKLR-KVQH 1903
Cdd:PRK12704  100 RKLEL-------LEKREEELEKKEKELEQKQQELEKKEEELEELIEEqLQELERisglTAEEAKEIL---LEKVEeEARH 169
                         170
                  ....*....|....*...
gi 288856329 1904 EL--------EEAEERAD 1913
Cdd:PRK12704  170 EAavlikeieEEAKEEAD 187
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
977-1113 4.70e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 41.77  E-value: 4.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  977 VKNLTEEMAAQDESIGKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKSKTKLEQQVDDLEGSLEqekklrmDLERAKRK 1056
Cdd:COG2433   373 IRGLSIEEALEELIEKELPEEEPEAEREKEHEERELTEEEEEIRRLEEQVERLEAEVEELEAELE-------EKDERIER 445
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 288856329 1057 LEGDLKLAQESimdlENDKQQSEEKLKKKDFETSQLLSKIEDEQSLGAQLQKKIKEL 1113
Cdd:COG2433   446 LERELSEARSE----ERREIRKDREISRLDREIERLERELEEERERIEELKRKLERL 498
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
1472-1707 4.87e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 41.35  E-value: 4.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1472 AQKEARSLSTELFKMKNSYEETLDQLETLKRENKNLQQEISDLTEQLGETGKSIHELEKskkavetEKAEIQTALEEAEG 1551
Cdd:COG3883    14 ADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQA-------EIAEAEAEIEERRE 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1552 TLEheesKILRVQLELNQVKSEIDRKLAEKD--EEIEQIkRNSQRITDSMQSTLDSEVRSRNDALRIKKKMEGDLNEMEI 1629
Cdd:COG3883    87 ELG----ERARALYRSGGSVSYLDVLLGSESfsDFLDRL-SALSKIADADADLLEELKADKAELEAKKAELEAKLAELEA 161
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 288856329 1630 QLSHANRQAAEAQKQLRNVQAQLKDAQLHLDDAVRGQEDMKEQVAMVERRNTLMQSEIEELRAALEQTERGRKVAEQE 1707
Cdd:COG3883   162 LKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 239
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
1793-1937 5.82e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.85  E-value: 5.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1793 KDLQHRLDEAEN----LAMKGGKKQLQKLESRVRELESEVEAEQRRGADAVKGVRKYERRVKELTYQTEEDKKNVNRLQD 1868
Cdd:COG1196   216 RELKEELKELEAelllLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLA 295
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 288856329 1869 LVDKLQLKVKAYKRQSEEAEEQANSHLSKLRKVQHELEEAEERADIAESQVNKLRAKSRDSGKGKDAAE 1937
Cdd:COG1196   296 ELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAE 364
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
898-1037 5.87e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 41.74  E-value: 5.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  898 ENLSDAEERCEGLIKSKIQLEAKLKETTERLEDEEEinaELTAKKRKLEDECSELKKDIDDLeltLAKVEKEkhaTENKV 977
Cdd:PRK00409  509 KLIGEDKEKLNELIASLEELERELEQKAEEAEALLK---EAEKLKEELEEKKEKLQEEEDKL---LEEAEKE---AQQAI 579
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  978 KNLTEEMAAQDESIGKLTKEKKALQEAHQQTlDDLQAEEDKVNTLTKSKTKLEQQVDDLE 1037
Cdd:PRK00409  580 KEAKKEADEIIKELRQLQKGGYASVKAHELI-EARKRLNKANEKKEKKKKKQKEKQEELK 638
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
929-1179 6.98e-03

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 41.45  E-value: 6.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  929 EDEEEINAELTAKKRKLEDECSELkkdIDDLElTLAKVEKEKHATENKVKnlteemaaqdesigkltkeKKALQEAHQQT 1008
Cdd:PRK05771   35 DLKEELSNERLRKLRSLLTKLSEA---LDKLR-SYLPKLNPLREEKKKVS-------------------VKSLEELIKDV 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1009 LDDLQAEEDKVNTLTKSKTKLEQQVDDLEGSLEQEKKLR---MDLERAKRK-----LEGDLKLAQESIMDLENDKQQSEE 1080
Cdd:PRK05771   92 EEELEKIEKEIKELEEEISELENEIKELEQEIERLEPWGnfdLDLSLLLGFkyvsvFVGTVPEDKLEELKLESDVENVEY 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1081 KLKKKDFETSQLLSKIEDEQSLGAQLQK---KIKELQARIEELEEEIEAERAARaKVEKQRADLSRELEEISERLEEAGG 1157
Cdd:PRK05771  172 ISTDKGYVYVVVVVLKELSDEVEEELKKlgfERLELEEEGTPSELIREIKEELE-EIEKERESLLEELKELAKKYLEELL 250
                         250       260
                  ....*....|....*....|..
gi 288856329 1158 ATAAQIEMNKKREAEFQKLRRD 1179
Cdd:PRK05771  251 ALYEYLEIELERAEALSKFLKT 272
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1383-1749 7.26e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 41.04  E-value: 7.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1383 QRTEELEESKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQGEVEDLMIDVERANALAANLDKKQRNFDKVLAEWKQKY 1462
Cdd:COG4372     3 RLGEKVGKARLSLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEEL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1463 EEGQAELEGAQKEARSLSTELFKMKNSYEETLDQLETLKRENKNLQQEISDLTEQLGETGKSIHELEKSKKAVETEKAEI 1542
Cdd:COG4372    83 EELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESL 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1543 QTALEEAEGTLEHEESKILRVQLELNQVKSEIDRKLAEKDEEIEQIKRNSQRITDSMQSTLDSEVRSRNDALRIKKKMEG 1622
Cdd:COG4372   163 QEELAALEQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDAL 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1623 DLNEMEIQLSHANRQAAEAQKQLRNVQAQLKDAQLHLDDAVRGQEDMKEQVAMVERRNTLMQSEIEELRAALEQTERGRK 1702
Cdd:COG4372   243 ELEEDKEELLEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALL 322
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 288856329 1703 VAEQELVDASERVGLLHSQNTSLLNTKKKLEADLVQIQSEVEDTVQE 1749
Cdd:COG4372   323 ELAKKLELALAILLAELADLLQLLLVGLLDNDVLELLSKGAEAGVAD 369
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
1779-1925 7.47e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 40.29  E-value: 7.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1779 AHLERMKKNLEVTVKDLQHRLDEAENlAMKGGKKQLQKLESRVRELESEVEAEQRRGA------DAVKGVRKYERRVKEL 1852
Cdd:COG1579    20 DRLEHRLKELPAELAELEDELAALEA-RLEAAKTELEDLEKEIKRLELEIEEVEARIKkyeeqlGNVRNNKEYEALQKEI 98
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 288856329 1853 TYQTEEDKKNVNRLQDLVDKLQLKVKAYKRQSEEAEEQANSHLSKLRKVQHELEEAEERADIAESQVNKLRAK 1925
Cdd:COG1579    99 ESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREELAAK 171
mukB PRK04863
chromosome partition protein MukB;
1266-1596 7.74e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 41.48  E-value: 7.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1266 DENLRQINDLSAQRARLQTEN---GEFGRQLEEkealvsqLTRGKQAFTQQIEELKRQIEeevKAKNALAHAVQSARHDC 1342
Cdd:PRK04863  286 EEALELRRELYTSRRQLAAEQyrlVEMARELAE-------LNEAESDLEQDYQAASDHLN---LVQTALRQQEKIERYQA 355
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1343 DL--LREQFEEEQEAKAEL--QRGMSKANSEVAQwrtkyetdaiqrtEELEESKKKLA---QRLQEAEEQIEAVNSKCAS 1415
Cdd:PRK04863  356 DLeeLEERLEEQNEVVEEAdeQQEENEARAEAAE-------------EEVDELKSQLAdyqQALDVQQTRAIQYQQAVQA 422
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1416 LEKTKQRLQgeVEDLmiDVERANALAANLDKKQRNFDKVLAEWKQKYEEGQA---ELEGAQKEARSLSTELFK--MKNSY 1490
Cdd:PRK04863  423 LERAKQLCG--LPDL--TADNAEDWLEEFQAKEQEATEELLSLEQKLSVAQAahsQFEQAYQLVRKIAGEVSRseAWDVA 498
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1491 EETLDQLETLKRENKNLQQ---EISDLTEQLGETGKSIH---ELEKSKKAVETEKAEIQTALEEAEGTLEHeeskilrvq 1564
Cdd:PRK04863  499 RELLRRLREQRHLAEQLQQlrmRLSELEQRLRQQQRAERllaEFCKRLGKNLDDEDELEQLQEELEARLES--------- 569
                         330       340       350
                  ....*....|....*....|....*....|..
gi 288856329 1565 leLNQVKSEIDRKLAEKDEEIEQIKRNSQRIT 1596
Cdd:PRK04863  570 --LSESVSEARERRMALRQQLEQLQARIQRLA 599
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
881-1043 7.94e-03

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 39.74  E-value: 7.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  881 ALLQEKNDLQLAVASESENLSDAEERCEGLIKSKIQLEAKLKETTERLEDE-EEINAELTAKKRKLED---------ECS 950
Cdd:cd00176    37 ALLKKHEALEAELAAHEERVEALNELGEQLIEEGHPDAEEIQERLEELNQRwEELRELAEERRQRLEEaldlqqffrDAD 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  951 ELKKDIDDLELTLAKVEKEKHATE-----NKVKNLTEEMAAQDESIGKLTKEKKALQEAHQQtlDDLQAEEDKVNTLTKS 1025
Cdd:cd00176   117 DLEQWLEEKEAALASEDLGKDLESveellKKHKELEEELEAHEPRLKSLNELAEELLEEGHP--DADEEIEEKLEELNER 194
                         170
                  ....*....|....*...
gi 288856329 1026 KTKLEQQVDDLEGSLEQE 1043
Cdd:cd00176   195 WEELLELAEERQKKLEEA 212
PRK11281 PRK11281
mechanosensitive channel MscK;
1256-1654 8.07e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 41.44  E-value: 8.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1256 DQLSEIKSKNDENLRQINDLSAQRARL-QTEngefgRQLEEKEALVSQLTrgkQAfTQQIEELKRQIEEeVKAKNALAHA 1334
Cdd:PRK11281   46 DALNKQKLLEAEDKLVQQDLEQTLALLdKID-----RQKEETEQLKQQLA---QA-PAKLRQAQAELEA-LKDDNDEETR 115
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1335 VQSARHDCDLLREQFEEEQEAKAELQRGMSKANSEVAQWRTKYEtdaiqRTE-ELEESkkklAQRLQEAEEQIEAVN-SK 1412
Cdd:PRK11281  116 ETLSTLSLRQLESRLAQTLDQLQNAQNDLAEYNSQLVSLQTQPE-----RAQaALYAN----SQRLQQIRNLLKGGKvGG 186
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1413 CASLEKTKQRLQGEVE--DLMIDVERaNALAAN-----LDKKQRNFdkvLAEWKQKYEEGQAELEGAQKEAR-SLStelf 1484
Cdd:PRK11281  187 KALRPSQRVLLQAEQAllNAQNDLQR-KSLEGNtqlqdLLQKQRDY---LTARIQRLEHQLQLLQEAINSKRlTLS---- 258
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1485 kmknsyEETLDQLETLKRENKN-----LQQEIS---DLTEQLGETGKSIHELekSKKAVETEK-----AEIQTALEEA-- 1549
Cdd:PRK11281  259 ------EKTVQEAQSQDEAARIqanplVAQELEinlQLSQRLLKATEKLNTL--TQQNLRVKNwldrlTQSERNIKEQis 330
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1550 --EGTLEHeeSKIL-RVQLELNQVKseIDRKLAEK--DEEIEQIKRNSQR------------ITDSMQSTLDSEVR-SRN 1611
Cdd:PRK11281  331 vlKGSLLL--SRILyQQQQALPSAD--LIEGLADRiaDLRLEQFEINQQRdalfqpdayidkLEAGHKSEVTDEVRdALL 406
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 288856329 1612 DALRIKKKMEGDLN-EMEIQLSHA-NRQAaeAQKQLRNVQAQLKD 1654
Cdd:PRK11281  407 QLLDERRELLDQLNkQLNNQLNLAiNLQL--NQQQLLSVSDSLQS 449
PRK10361 PRK10361
DNA recombination protein RmuC; Provisional
926-1109 8.27e-03

DNA recombination protein RmuC; Provisional


Pssm-ID: 182409 [Multi-domain]  Cd Length: 475  Bit Score: 40.74  E-value: 8.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  926 ERLEDEEEINAELTAKKRKL------EDECSELKkdiddleltlakvekekhateNKVKNLTEEMAAQDESIGKLTKEKK 999
Cdd:PRK10361   33 EQLAEREEMVAELSAAKQQItqsehwRAECELLN---------------------NEVRSLQSINTSLEADLREVTTRME 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1000 ALQeahqqtlddlQAEEDKVNTLTKSKTKLEQQVDDLEGSLEQEKKLRMDlERAKRKLEGDLKLAQESimdLENDKQQSE 1079
Cdd:PRK10361   92 AAQ----------QHADDKIRQMINSEQRLSEQFENLANRIFEHSNRRVD-EQNRQSLNSLLSPLREQ---LDGFRRQVQ 157
                         170       180       190
                  ....*....|....*....|....*....|
gi 288856329 1080 EKLKKKDFETSQLLSKIEDEQSLGAQLQKK 1109
Cdd:PRK10361  158 DSFGKEAQERHTLAHEIRNLQQLNAQMAQE 187
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
1314-1535 8.38e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 41.00  E-value: 8.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1314 IEElKRQIEEEVKAKN-----ALAHAVQSARHdcdlLREQFEE-EQEAKAELQRGMSKAnsEVAQWRTKYETDAIQRTEE 1387
Cdd:COG2433   317 VEE-KLHLAREYGYDNdherdALAAALKAYDA----YKNKFERvEKKVPPDVDRDEVKA--RVIRGLSIEEALEELIEKE 389
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1388 LEESKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQGEVEDLmidveranalaanldkKQRnfdkvLAEWKQKYEEGQA 1467
Cdd:COG2433   390 LPEEEPEAEREKEHEERELTEEEEEIRRLEEQVERLEAEVEEL----------------EAE-----LEEKDERIERLER 448
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 288856329 1468 ELEGAQKEARS---LSTELFKMKNSYEETLDQLETLKRENKNLQQEISDLteqlgetgKSIHELEKSKKAV 1535
Cdd:COG2433   449 ELSEARSEERReirKDREISRLDREIERLERELEEERERIEELKRKLERL--------KELWKLEHSGELV 511
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
1133-1327 8.70e-03

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 41.07  E-value: 8.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1133 KVEKQRADLSRELEEISERLEEAGGATAAQIEMNKKREAEFQKlrrDLEESTLQHEataaalrkkqaDSVAELGEQIDNL 1212
Cdd:PRK05771   47 KLRSLLTKLSEALDKLRSYLPKLNPLREEKKKVSVKSLEELIK---DVEEELEKIE-----------KEIKELEEEISEL 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1213 QRVKQKLEKEKSE------YKMEIDDL--SSNMEA-VAKAKANLEKMCRTLEDQLSEIKSKNDEN--------------- 1268
Cdd:PRK05771  113 ENEIKELEQEIERlepwgnFDLDLSLLlgFKYVSVfVGTVPEDKLEELKLESDVENVEYISTDKGyvyvvvvvlkelsde 192
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1269 -LRQINDLSAQRARLQTEnGEFGRQLEEKEALVSQLTRGKQAFTQQIEELKRQIEEEVKA 1327
Cdd:PRK05771  193 vEEELKKLGFERLELEEE-GTPSELIREIKEELEEIEKERESLLEELKELAKKYLEELLA 251
Tropomyosin pfam00261
Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 ...
1738-1922 8.96e-03

Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 parallel helices containing 2 sets of 7 alternating actin binding sites. The protein is best known for its role in regulating the interaction between actin and myosin in muscle contraction, but is also involved in the organization and dynamics of the cytoskeleton in non-muscle cells. There are multiple cell-specific isoforms, expressed by alternative promoters and alternative RNA processing of at least four genes. Muscle isoforms of tropomyosin are characterized by having 284 amino acid residues and a highly conserved N-terminal region, whereas non-muscle forms are generally smaller and are heterogeneous in their N-terminal region.


Pssm-ID: 459736 [Multi-domain]  Cd Length: 235  Bit Score: 40.01  E-value: 8.96e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1738 QIQSEVEDTVQEARNAEDK---AKKAITDAAMMAEELKKE-QDTSAHLERMKKNLEVTvkdlQHRLDEAENLA------M 1807
Cdd:pfam00261    5 QIKEELDEAEERLKEAMKKleeAEKRAEKAEAEVAALNRRiQLLEEELERTEERLAEA----LEKLEEAEKAAdesergR 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329  1808 KGGKKQLQKLESRVRELESEVEAEQRRGADAVKGVRKYERRVKELTYQTE--EDK--KNVNRLQDLVDKLQL---KVKAY 1880
Cdd:pfam00261   81 KVLENRALKDEEKMEILEAQLKEAKEIAEEADRKYEEVARKLVVVEGDLEraEERaeLAESKIVELEEELKVvgnNLKSL 160
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 288856329  1881 KRQSEEAEEQANSHLSKLRKVQHELEEAEERADIAESQVNKL 1922
Cdd:pfam00261  161 EASEEKASEREDKYEEQIRFLTEKLKEAETRAEFAERSVQKL 202
mukB PRK04863
chromosome partition protein MukB;
1163-1900 9.64e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 41.10  E-value: 9.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1163 IEMNKKREAEFQKLrrdLEEST-------LQHEA-------TAAALRKKQADSVAELGEQIDNLQRVKQKLE---KEKSE 1225
Cdd:PRK04863  249 IRVTQSDRDLFKHL---ITESTnyvaadyMRHANerrvhleEALELRRELYTSRRQLAAEQYRLVEMARELAelnEAESD 325
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1226 YKMEIDDLSSNMEAVAKAKANLEKMCRTLEDqLSEIKSKNDENLRQINDLSAQRARLQTEngeFGRQLEEKEALVSQLTR 1305
Cdd:PRK04863  326 LEQDYQAASDHLNLVQTALRQQEKIERYQAD-LEELEERLEEQNEVVEEADEQQEENEAR---AEAAEEEVDELKSQLAD 401
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1306 GKQAF-TQQIEELKRQieeevKAKNALahavQSARHDCDL--------------LREQFEEEQEAKAELQRGMSKANSEV 1370
Cdd:PRK04863  402 YQQALdVQQTRAIQYQ-----QAVQAL----ERAKQLCGLpdltadnaedwleeFQAKEQEATEELLSLEQKLSVAQAAH 472
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1371 AQWRTKYE-----TDAIQRTEELEESKKKLAQ--RLQEAEEQIEAVNSKCASLEktkQRLQgevedlmidveranalaan 1443
Cdd:PRK04863  473 SQFEQAYQlvrkiAGEVSRSEAWDVARELLRRlrEQRHLAEQLQQLRMRLSELE---QRLR------------------- 530
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1444 ldkKQRNFDKVLAEWKQKYEEGQAELEGAQKEARSLSTELFKMKNSYEETLDQLETLKRENKNLQQEISDLT-------- 1515
Cdd:PRK04863  531 ---QQQRAERLLAEFCKRLGKNLDDEDELEQLQEELEARLESLSESVSEARERRMALRQQLEQLQARIQRLAarapawla 607
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1516 ---------EQLGETGKSIHELEKSKKavetekaeiQTALEEAEGTLEHEEskilrVQLELNQVKSEIDRKLAEKDEEIE 1586
Cdd:PRK04863  608 aqdalarlrEQSGEEFEDSQDVTEYMQ---------QLLERERELTVERDE-----LAARKQALDEEIERLSQPGGSEDP 673
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1587 QIKRNSQRITDSMQSTLDSEVrSRNDAlrikkkmeGDLNEMEIQLSHA--NRQAAEAQKQLRNVQAQLKDAQL------H 1658
Cdd:PRK04863  674 RLNALAERFGGVLLSEIYDDV-SLEDA--------PYFSALYGPARHAivVPDLSDAAEQLAGLEDCPEDLYLiegdpdS 744
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1659 LDDAVRGQEDMKEQVAMVERRNTLMQSEIEEL----RAA----LEQTERGRKVAEQELVDASERVGL---LHSQNTSLLN 1727
Cdd:PRK04863  745 FDDSVFSVEELEKAVVVKIADRQWRYSRFPEVplfgRAArekrIEQLRAEREELAERYATLSFDVQKlqrLHQAFSRFIG 824
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1728 TK-------------KKLEADLVQIQSEVED---TVQEARNAEDKAKKAITDAAMMAEELKKEQDTSaHLERmkknlevt 1791
Cdd:PRK04863  825 SHlavafeadpeaelRQLNRRRVELERALADhesQEQQQRSQLEQAKEGLSALNRLLPRLNLLADET-LADR-------- 895
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288856329 1792 VKDLQHRLDEAEN----LAMKGGK-KQLQKLESRVRELESEVEAEQRRGADAVKGVRKYERRVKELTY--------QTEE 1858
Cdd:PRK04863  896 VEEIREQLDEAEEakrfVQQHGNAlAQLEPIVSVLQSDPEQFEQLKQDYQQAQQTQRDAKQQAFALTEvvqrrahfSYED 975
                         810       820       830       840
                  ....*....|....*....|....*....|....*....|..
gi 288856329 1859 DKKNVNRLQDLVDKLQLKVKAYKRQSEEAEEQANSHLSKLRK 1900
Cdd:PRK04863  976 AAEMLAKNSDLNEKLRQRLEQAEQERTRAREQLRQAQAQLAQ 1017
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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