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Conserved domains on  [gi|197333706|ref|NP_001127951|]
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volume-regulated anion channel subunit LRRC8D [Homo sapiens]

Protein Classification

Pannexin_like and LRR domain-containing protein( domain architecture ID 12117038)

Pannexin_like and LRR domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-384 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


:

Pssm-ID: 463622  Cd Length: 345  Bit Score: 623.49  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706    1 MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPSPVNSKAHtppgnaevttnip 80
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVCLPCLESPPSTASL------------- 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706   81 kmeaatnqdqDGRTTNDISFGTSAVTPDIPLRATYPrtdfalpnqeakkekkDPTGRKTNLDFQQYVFINQMCYHLALPW 160
Cdd:pfam12534  68 ----------DDSYANSLSPTQSAPTVSSPSASMIP----------------EPKGRKTNLDRQQYVFINQVCYEKALHW 121

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706  161 YSKYFPYLALIHTIILMVSSNFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKhVST 240
Cdd:pfam12534 122 YSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVSILGKCFDSPWTTRALSETSGEDSEEKKQRLEGNTVLPK-VSS 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706  241 SSDEGSPSASTPMINKTGFKFSAEKPVIEVPS-MTILDKKDGEQAKALFEKVRKFRAHVEDSDLIYKLYVVQTVIKTAKF 319
Cdd:pfam12534 201 SSSLSSSDESAPLTRTPSVKSSPEKPVVEVPStVSVLDKKEGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKF 280

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 197333706  320 IFILCYTANFVNAISFEHVCKPKVEHLIGYEVFECTHNMAYMLKKLLISYISIICVYGFICLYTL 384
Cdd:pfam12534 281 LLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNLAFLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
558-851 5.41e-41

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 155.86  E-value: 5.41e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 558 LLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNV 637
Cdd:COG4886   19 ELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNL 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 638 AELELQNCEleriphAIFSLSNLQELDLKSNNIRTIEEIISfqHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNK 717
Cdd:COG4886   99 TELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELA--NLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQ 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 718 LESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEkVGQL 797
Cdd:COG4886  171 LTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE-LGNL 249

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 197333706 798 SQLTQLELKGNCLDRLPAqLGQCRMLKKsgLVVEDHLFDTLPLEVKEALNQDIN 851
Cdd:COG4886  250 TNLEELDLSNNQLTDLPP-LANLTNLKT--LDLSNNQLTDLKLKELELLLGLNS 300
 
Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-384 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


Pssm-ID: 463622  Cd Length: 345  Bit Score: 623.49  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706    1 MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPSPVNSKAHtppgnaevttnip 80
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVCLPCLESPPSTASL------------- 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706   81 kmeaatnqdqDGRTTNDISFGTSAVTPDIPLRATYPrtdfalpnqeakkekkDPTGRKTNLDFQQYVFINQMCYHLALPW 160
Cdd:pfam12534  68 ----------DDSYANSLSPTQSAPTVSSPSASMIP----------------EPKGRKTNLDRQQYVFINQVCYEKALHW 121

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706  161 YSKYFPYLALIHTIILMVSSNFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKhVST 240
Cdd:pfam12534 122 YSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVSILGKCFDSPWTTRALSETSGEDSEEKKQRLEGNTVLPK-VSS 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706  241 SSDEGSPSASTPMINKTGFKFSAEKPVIEVPS-MTILDKKDGEQAKALFEKVRKFRAHVEDSDLIYKLYVVQTVIKTAKF 319
Cdd:pfam12534 201 SSSLSSSDESAPLTRTPSVKSSPEKPVVEVPStVSVLDKKEGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKF 280

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 197333706  320 IFILCYTANFVNAISFEHVCKPKVEHLIGYEVFECTHNMAYMLKKLLISYISIICVYGFICLYTL 384
Cdd:pfam12534 281 LLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNLAFLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
558-851 5.41e-41

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 155.86  E-value: 5.41e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 558 LLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNV 637
Cdd:COG4886   19 ELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNL 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 638 AELELQNCEleriphAIFSLSNLQELDLKSNNIRTIEEIISfqHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNK 717
Cdd:COG4886   99 TELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELA--NLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQ 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 718 LESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEkVGQL 797
Cdd:COG4886  171 LTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE-LGNL 249

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 197333706 798 SQLTQLELKGNCLDRLPAqLGQCRMLKKsgLVVEDHLFDTLPLEVKEALNQDIN 851
Cdd:COG4886  250 TNLEELDLSNNQLTDLPP-LANLTNLKT--LDLSNNQLTDLKLKELELLLGLNS 300
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 590-841 4.76e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 82.97  E-value: 4.76e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 590 LKILHVKSNLT--KVPSNITDvaphLTKLVIHNDGTKLLV---LNSLKKMMNVAELELQNCELE-RIPHAIFSLSNLQEL 663
Cdd:PLN00113 166 LKVLDLGGNVLvgKIPNSLTN----LTSLEFLTLASNQLVgqiPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHL 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 664 DLKSNNIrTIEEIISFQHLKRLTCLKLWHNKIV-TIPPSITHVKNLESLYFSNNKLE-SLPVAVFSLQKLRCLDVSYNNI 741
Cdd:PLN00113 242 DLVYNNL-TGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNF 320

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 742 S-MIPIEIGLLQNLQHLHITGNKVD-ILPKQLFKCIKLRTLNLGQNCITS-LPEKVGQLSQLTQLELKGNCLD-RLPAQL 817
Cdd:PLN00113 321 TgKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTGeIPEGLCSSGNLFKLILFSNSLEgEIPKSL 400

                        250       260
                 ....*....|....*....|....
gi 197333706 818 GQCRMLKKSGLvVEDHLFDTLPLE 841
Cdd:PLN00113 401 GACRSLRRVRL-QDNSFSGELPSE 423
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 640-814 6.99e-16

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 77.52  E-value: 6.99e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 640 LELQNCELERIPhAIFSLSNLQELDLKSNNIRTIEeiiSFQHLKRLTCLKLWHNKIVTIPPsITHVKNLESLYFSNNK-- 717
Cdd:cd21340    7 LYLNDKNITKID-NLSLCKNLKVLYLYDNKITKIE---NLEFLTNLTHLYLQNNQIEKIEN-LENLVNLKKLYLGGNRis 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 718 -LESLPvavfSLQKLRCLDVSYNNI-----------SMIpieiGLLQNLQHLHITGNKVDILpKQLFKCIKLRTLNLGQN 785
Cdd:cd21340   82 vVEGLE----NLTNLEELHIENQRLppgekltfdprSLA----ALSNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNN 152

                        170       180       190
                 ....*....|....*....|....*....|..
gi 197333706 786 CITSLPE---KVGQLSQLTQLELKGNCLDRLP 814
Cdd:cd21340  153 QISDLEElldLLSSWPSLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
636-695 1.56e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 1.56e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 197333706  636 NVAELELQNCELERI-PHAIFSLSNLQELDLKSNNIRTIEEiISFQHLKRLTCLKLWHNKI 695
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-384 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


Pssm-ID: 463622  Cd Length: 345  Bit Score: 623.49  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706    1 MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPSPVNSKAHtppgnaevttnip 80
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVCLPCLESPPSTASL------------- 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706   81 kmeaatnqdqDGRTTNDISFGTSAVTPDIPLRATYPrtdfalpnqeakkekkDPTGRKTNLDFQQYVFINQMCYHLALPW 160
Cdd:pfam12534  68 ----------DDSYANSLSPTQSAPTVSSPSASMIP----------------EPKGRKTNLDRQQYVFINQVCYEKALHW 121

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706  161 YSKYFPYLALIHTIILMVSSNFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKhVST 240
Cdd:pfam12534 122 YSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVSILGKCFDSPWTTRALSETSGEDSEEKKQRLEGNTVLPK-VSS 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706  241 SSDEGSPSASTPMINKTGFKFSAEKPVIEVPS-MTILDKKDGEQAKALFEKVRKFRAHVEDSDLIYKLYVVQTVIKTAKF 319
Cdd:pfam12534 201 SSSLSSSDESAPLTRTPSVKSSPEKPVVEVPStVSVLDKKEGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKF 280

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 197333706  320 IFILCYTANFVNAISFEHVCKPKVEHLIGYEVFECTHNMAYMLKKLLISYISIICVYGFICLYTL 384
Cdd:pfam12534 281 LLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNLAFLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
558-851 5.41e-41

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 155.86  E-value: 5.41e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 558 LLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNV 637
Cdd:COG4886   19 ELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNL 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 638 AELELQNCEleriphAIFSLSNLQELDLKSNNIRTIEEIISfqHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNK 717
Cdd:COG4886   99 TELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELA--NLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQ 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 718 LESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEkVGQL 797
Cdd:COG4886  171 LTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE-LGNL 249

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 197333706 798 SQLTQLELKGNCLDRLPAqLGQCRMLKKsgLVVEDHLFDTLPLEVKEALNQDIN 851
Cdd:COG4886  250 TNLEELDLSNNQLTDLPP-LANLTNLKT--LDLSNNQLTDLKLKELELLLGLNS 300
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
546-813 9.38e-39

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 149.31  E-value: 9.38e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 546 FTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLTKVPSNITDVApHLTKLVIHNdgtkl 625
Cdd:COG4886   32 LLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLT-NLTELDLSG----- 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 626 lvLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEiiSFQHLKRLTCLKLWHNKIVTIPPSITHV 705
Cdd:COG4886  106 --NEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE--PLGNLTNLKSLDLSNNQLTDLPEELGNL 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 706 KNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPkQLFKCIKLRTLNLGQN 785
Cdd:COG4886  182 TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNN 260

                        250       260
                 ....*....|....*....|....*...
gi 197333706 786 CITSLPEkVGQLSQLTQLELKGNCLDRL 813
Cdd:COG4886  261 QLTDLPP-LANLTNLKTLDLSNNQLTDL 287
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
561-825 1.07e-35

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 140.45  E-value: 1.07e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 561 NLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKmmNVAEL 640
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLL--LLLLS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 641 ELQNCELERIPHAIFSLSNLQELDLKSNNirtieeiiSFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLES 720
Cdd:COG4886   79 LLLLSLLLLGLTDLGDLTNLTELDLSGNE--------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTD 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 721 LPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQL 800
Cdd:COG4886  151 LPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNL 230

                        250       260
                 ....*....|....*....|....*
gi 197333706 801 TQLELKGNCLDRLPaQLGQCRMLKK 825
Cdd:COG4886  231 ETLDLSNNQLTDLP-ELGNLTNLEE 254
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
547-856 2.81e-33

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 133.52  E-value: 2.81e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 547 TDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNltkvpSNITDVApHLTKLVIHNdgTKLL 626
Cdd:COG4886   55 LLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-----EELSNLT-NLESLDLSG--NQLT 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 627 VL-NSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEiiSFQHLKRLTCLKLWHNKIVTIPPSITHV 705
Cdd:COG4886  127 DLpEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPE--ELGNLTNLKELDLSNNQITDLPEPLGNL 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 706 KNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPiEIGLLQNLQHLHITGNKVDILPKqLFKCIKLRTLNLGQN 785
Cdd:COG4886  205 TNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNN 282

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 197333706 786 CITSLpeKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEVKEALNQDINIPFAN 856
Cdd:COG4886  283 QLTDL--KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLT 351
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
488-808 3.96e-27

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 115.03  E-value: 3.96e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 488 DLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTafsflrdHLRCLHVKFTDVAEIPAWVYLLKNLRELYL 567
Cdd:COG4886   71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLT-------NLESLDLSGNQLTDLPEELANLTNLKELDL 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 568 ignlnsENNKMIGL-ESLRELRHLKILHVKSNltkvpsNITDVAPHLTKLVihndgtkllvlnSLKkmmnvaELELQNCE 646
Cdd:COG4886  144 ------SNNQLTDLpEPLGNLTNLKSLDLSNN------QLTDLPEELGNLT------------NLK------ELDLSNNQ 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 647 LERIPHAIFSLSNLQELDLKSNNIRTIEEiiSFQHLKRLTCLKLWHNKIVTIPpSITHVKNLESLYFSNNKLESLPvAVF 726
Cdd:COG4886  194 ITDLPEPLGNLTNLEELDLSGNQLTDLPE--PLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLP-PLA 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 727 SLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELK 806
Cdd:COG4886  270 NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLAL 349


                 ..
gi 197333706 807 GN 808
Cdd:COG4886  350 LT 351
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
405-805 3.64e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.07  E-value: 3.64e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 405 SFSDIPDVKNDFAFLLHMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFMLSGVPD 484
Cdd:COG4886   11 KLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLT 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 485 AVFDLTDLDVLKLELIPEakipakISQMTNLQELHLCHCPAKVEQTAFSFLRdHLRCLHVKFTDVAEIPAWVYLLKNLRE 564
Cdd:COG4886   91 DLGDLTNLTELDLSGNEE------LSNLTNLESLDLSGNQLTDLPEELANLT-NLKELDLSNNQLTDLPEPLGNLTNLKS 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 565 LYLignlnsENNKMIGL-ESLRELRHLKILHVKSN-LTKVPSNITDvAPHLTKLVIhnDGTKLLVL-NSLKKMMNVAELE 641
Cdd:COG4886  164 LDL------SNNQLTDLpEELGNLTNLKELDLSNNqITDLPEPLGN-LTNLEELDL--SGNQLTDLpEPLANLTNLETLD 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 642 LQNCELERIPhAIFSLSNLQELDLKSNNIRTIEEIisfQHLKRLTCLKLWHNKIVTIP-PSITHVKNLESLYFSNNKLES 720
Cdd:COG4886  235 LSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPL---ANLTNLKTLDLSNNQLTDLKlKELELLLGLNSLLLLLLLLNL 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 721 LPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQL 800
Cdd:COG4886  311 LELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLL 390


                 ....*
gi 197333706 801 TQLEL 805
Cdd:COG4886  391 LLLLT 395
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 590-841 4.76e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 82.97  E-value: 4.76e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 590 LKILHVKSNLT--KVPSNITDvaphLTKLVIHNDGTKLLV---LNSLKKMMNVAELELQNCELE-RIPHAIFSLSNLQEL 663
Cdd:PLN00113 166 LKVLDLGGNVLvgKIPNSLTN----LTSLEFLTLASNQLVgqiPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHL 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 664 DLKSNNIrTIEEIISFQHLKRLTCLKLWHNKIV-TIPPSITHVKNLESLYFSNNKLE-SLPVAVFSLQKLRCLDVSYNNI 741
Cdd:PLN00113 242 DLVYNNL-TGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNF 320

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 742 S-MIPIEIGLLQNLQHLHITGNKVD-ILPKQLFKCIKLRTLNLGQNCITS-LPEKVGQLSQLTQLELKGNCLD-RLPAQL 817
Cdd:PLN00113 321 TgKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTGeIPEGLCSSGNLFKLILFSNSLEgEIPKSL 400

                        250       260
                 ....*....|....*....|....
gi 197333706 818 GQCRMLKKSGLvVEDHLFDTLPLE 841
Cdd:PLN00113 401 GACRSLRRVRL-QDNSFSGELPSE 423
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 640-814 6.99e-16

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 77.52  E-value: 6.99e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 640 LELQNCELERIPhAIFSLSNLQELDLKSNNIRTIEeiiSFQHLKRLTCLKLWHNKIVTIPPsITHVKNLESLYFSNNK-- 717
Cdd:cd21340    7 LYLNDKNITKID-NLSLCKNLKVLYLYDNKITKIE---NLEFLTNLTHLYLQNNQIEKIEN-LENLVNLKKLYLGGNRis 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 718 -LESLPvavfSLQKLRCLDVSYNNI-----------SMIpieiGLLQNLQHLHITGNKVDILpKQLFKCIKLRTLNLGQN 785
Cdd:cd21340   82 vVEGLE----NLTNLEELHIENQRLppgekltfdprSLA----ALSNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNN 152

                        170       180       190
                 ....*....|....*....|....*....|..
gi 197333706 786 CITSLPE---KVGQLSQLTQLELKGNCLDRLP 814
Cdd:cd21340  153 QISDLEElldLLSSWPSLRELDLTGNPVCKKP 184
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 636-791 1.43e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 76.75  E-value: 1.43e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 636 NVAELELQNCELERIPHaIFSLSNLQELDLKSNNIRTIEeiiSFQHLKRLTCLKLWHNKIVTIpPSITHVKNLESLYFSN 715
Cdd:cd21340   25 NLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKIE---NLENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIEN 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 716 NKL---ESL---PVAVFSLQK-LRCLDVSYNNISmIPIEIGLLQNLQHLHITGNKVDILPKQ---LFKCIKLRTLNLGQN 785
Cdd:cd21340  100 QRLppgEKLtfdPRSLAALSNsLRVLNISGNNID-SLEPLAPLRNLEQLDASNNQISDLEELldlLSSWPSLRELDLTGN 178


                 ....*.
gi 197333706 786 CITSLP 791
Cdd:cd21340  179 PVCKKP 184
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 449-839 1.00e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 72.19  E-value: 1.00e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 449 ISLNH-EWTFEKLRQHISRNAQDKQELH-LF----MLSG-VPDAVFDLTDLDVLKL-ELIPEAKIPAKISQMTNLQELHL 520
Cdd:PLN00113 236 TSLNHlDLVYNNLTGPIPSSLGNLKNLQyLFlyqnKLSGpIPPSIFSLQKLISLDLsDNSLSGEIPELVIQLQNLEILHL 315

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 521 chcpakveqtaFSflrdhlrclhVKFTdvAEIPAWVYLLKNLRELYLIGN-LNSENNKMIGLESlrelrHLKILHVKSN- 598
Cdd:PLN00113 316 -----------FS----------NNFT--GKIPVALTSLPRLQVLQLWSNkFSGEIPKNLGKHN-----NLTVLDLSTNn 367

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 599 LT-KVPSNITDvAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELE-RIPHAIFSLSNLQELDLKSNNIrtieei 676
Cdd:PLN00113 368 LTgEIPEGLCS-SGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNL------ 440

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 677 isfqhLKRLTCLKlWHnkivtippsithVKNLESLYFSNNK-LESLPvAVFSLQKLRCLDVSYNNIS-MIPIEIGLLQNL 754
Cdd:PLN00113 441 -----QGRINSRK-WD------------MPSLQMLSLARNKfFGGLP-DSFGSKRLENLDLSRNQFSgAVPRKLGSLSEL 501

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 755 QHLHITGNKVD-ILPKQLFKCIKLRTLNLGQNCIT-SLPEKVGQLSQLTQLELKGNCLD-RLPAQLGQCRMLKKSGLvVE 831
Cdd:PLN00113 502 MQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNI-SH 580


                 ....*...
gi 197333706 832 DHLFDTLP 839
Cdd:PLN00113 581 NHLHGSLP 588
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 504-823 1.68e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 71.42  E-value: 1.68e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 504 KIPAKISQMTNLQELHLC------HCPAKVEQ-TAFSFLRDHLRCLhvkftdVAEIPAWVYLLKNLRELYL-IGNLNSEN 575
Cdd:PLN00113 155 EIPNDIGSFSSLKVLDLGgnvlvgKIPNSLTNlTSLEFLTLASNQL------VGQIPRELGQMKSLKWIYLgYNNLSGEI 228

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 576 NKMIGleSLRELRHLKIlhVKSNLT-KVPSNITDVApHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELE-RIPHA 653
Cdd:PLN00113 229 PYEIG--GLTSLNHLDL--VYNNLTgPIPSSLGNLK-NLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSgEIPEL 303

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 654 IFSLSNLQELDLKSNNIR-TIEEIISfqHLKRLTCLKLWHNKIV------------------------------------ 696
Cdd:PLN00113 304 VIQLQNLEILHLFSNNFTgKIPVALT--SLPRLQVLQLWSNKFSgeipknlgkhnnltvldlstnnltgeipeglcssgn 381

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 697 -------------TIPPSITHVKNLESLYFSNNKLE-SLPVAVFSLQKLRCLDVSYNNIS-MIPIEIGLLQNLQHLHITG 761
Cdd:PLN00113 382 lfklilfsnslegEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNLQgRINSRKWDMPSLQMLSLAR 461

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 197333706 762 NKVDILPKQLFKCIKLRTLNLGQNCIT-SLPEKVGQLSQLTQLELKGNCLD-RLPAQLGQCRML 823
Cdd:PLN00113 462 NKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKL 525
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
586-817 2.52e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 70.88  E-value: 2.52e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 586 ELRhLKILhvksNLTKVPSNITDvapHLTKLVIHNDGTKLLVLNSlkkMMNVAELELQNCELERIPHAIfsLSNLQELDL 665
Cdd:PRK15370 182 ELR-LKIL----GLTTIPACIPE---QITTLILDNNELKSLPENL---QGNIKTLYANSNQLTSIPATL--PDTIQEMEL 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 666 KSNNIRTIEEiisfqHL-KRLTCLKLWHNKIVTIPpsithvknleslyfsnnklESLPvavfslQKLRCLDVSYNNISMI 744
Cdd:PRK15370 249 SINRITELPE-----RLpSALQSLDLFHNKISCLP-------------------ENLP------EELRYLSVYDNSIRTL 298

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 197333706 745 PIEigLLQNLQHLHITGNKVDILPKQLfkCIKLRTLNLGQNCITSLPEKVGqlSQLTQLELKGNCLDRLPAQL 817
Cdd:PRK15370 299 PAH--LPSGITHLNVQSNSLTALPETL--PPGLKTLEAGENALTSLPASLP--PELQVLDVSKNQITVLPETL 365
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 682-825 8.86e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.50  E-value: 8.86e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 682 LKRLTCLKLWHNKIVTIP---------------------PSITHVKNLESLYFSNNKLESLPVaVFSLQKLRCLDVSYNN 740
Cdd:cd21340    1 LKRITHLYLNDKNITKIDnlslcknlkvlylydnkitkiENLEFLTNLTHLYLQNNQIEKIEN-LENLVNLKKLYLGGNR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 741 ISMIpieIGL--LQNLQHLHI------TGNKVDILPKQLF---KCikLRTLNLGQNCITSLpEKVGQLSQLTQLELKGNC 809
Cdd:cd21340   80 ISVV---EGLenLTNLEELHIenqrlpPGEKLTFDPRSLAalsNS--LRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQ 153

                        170
                 ....*....|....*....
gi 197333706 810 LDRLPAQ---LGQCRMLKK 825
Cdd:cd21340  154 ISDLEELldlLSSWPSLRE 172
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 640-808 2.47e-08

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 57.11  E-value: 2.47e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 640 LELQNCELERIPHAIFSLSNLQELDLKSNNI--RTIEEIIS-FQHLKRLTCLKLWHNKI-----VTIPPSITHVKNLESL 711
Cdd:COG5238  190 NQIGDEGIEELAEALTQNTTVTTLWLKRNPIgdEGAEILAEaLKGNKSLTTLDLSNNQIgdegvIALAEALKNNTTVETL 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 712 YFSNNKL-----ESLPVAVFSLQKLRCLDVSYNNISMiPIEIGLLQNLQHLHItgnkvdilpkqlfkcikLRTLNLGQNC 786
Cdd:COG5238  270 YLSGNQIgaegaIALAKALQGNTTLTSLDLSVNRIGD-EGAIALAEGLQGNKT-----------------LHTLNLAYNG 331

                        170       180
                 ....*....|....*....|....*..
gi 197333706 787 IT-----SLPEKVGQLSQLTQLELKGN 808
Cdd:COG5238  332 IGaqgaiALAKALQENTTLHSLDLSDN 358
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 540-716 1.32e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.25  E-value: 1.32e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 540 RCLHVKFTD--VAEIPAwVYLLKNLRELYL-------IGNLNS---------ENNKMIGLESLRELRHLKILHVKSNltk 601
Cdd:cd21340    3 RITHLYLNDknITKIDN-LSLCKNLKVLYLydnkitkIENLEFltnlthlylQNNQIEKIENLENLVNLKKLYLGGN--- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 602 vpsNITdvaphltklvihndgtkllVLNSLKKMMNVAELELQN------CELERIPHAIFSLSN-LQELDLKSNNIRTIE 674
Cdd:cd21340   79 ---RIS-------------------VVEGLENLTNLEELHIENqrlppgEKLTFDPRSLAALSNsLRVLNISGNNIDSLE 136

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 197333706 675 EiisFQHLKRLTCLKLWHNKIVTIP---PSITHVKNLESLYFSNN 716
Cdd:cd21340  137 P---LAPLRNLEQLDASNNQISDLEellDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
636-695 1.56e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 1.56e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 197333706  636 NVAELELQNCELERI-PHAIFSLSNLQELDLKSNNIRTIEEiISFQHLKRLTCLKLWHNKI 695
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
658-718 2.37e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.29  E-value: 2.37e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 197333706  658 SNLQELDLKSNNIRTIEEIiSFQHLKRLTCLKLWHNKIVTIPP-SITHVKNLESLYFSNNKL 718
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDG-AFKGLSNLKVLDLSNNLLTTLSPgAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
684-741 9.93e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 9.93e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706  684 RLTCLKLWHNKIVTIPPSI-THVKNLESLYFSNNKLESLPVAVFS-LQKLRCLDVSYNNI 741
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGAFSgLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
660-816 1.13e-06

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 52.47  E-value: 1.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 660 LQELDLKSNNIRTIEEIISfqhlkrlTCLKLW--HNKIVTIPpsiTHVKNLESLYFSNNKLESLPVAVFSLQKL------ 731
Cdd:PRK15387 304 LQELSVSDNQLASLPALPS-------ELCKLWayNNQLTSLP---TLPSGLQELSVSDNQLASLPTLPSELYKLwaynnr 373

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 732 -----------RCLDVSYNNISMIPIeigLLQNLQHLHITGNKVDILPkqlFKCIKLRTLNLGQNCITSLPEKVGQLSQL 800
Cdd:PRK15387 374 ltslpalpsglKELIVSGNRLTSLPV---LPSELKELMVSGNRLTSLP---MLPSGLLSLSVYRNQLTRLPESLIHLSSE 447

                        170
                 ....*....|....*.
gi 197333706 801 TQLELKGNCLDRLPAQ 816
Cdd:PRK15387 448 TTVNLEGNPLSERTLQ 463
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 649-829 2.49e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.39  E-value: 2.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 649 RIPHAIFSLSNLQELDLKSNNIrtieeiiSFQhlkrltclklwhnkivtIPPSI-THVKNLESLYFSNNKLeSLPVAVFS 727
Cdd:PLN00113  84 KISSAIFRLPYIQTINLSNNQL-------SGP-----------------IPDDIfTTSSSLRYLNLSNNNF-TGSIPRGS 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 728 LQKLRCLDVSYNNIS-MIPIEIGLLQNLQHLHITGNK-VDILPKQLFKCIKLRTLNLGQNCIT-SLPEKVGQLSQLTQLE 804
Cdd:PLN00113 139 IPNLETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVlVGKIPNSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWIY 218

                        170       180
                 ....*....|....*....|....*.
gi 197333706 805 LKGNCLD-RLPAQLGQCRMLKKSGLV 829
Cdd:PLN00113 219 LGYNNLSgEIPYEIGGLTSLNHLDLV 244
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 559-711 5.55e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.24  E-value: 5.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 559 LKNLRELYLIGNLNSennKMIGLESLRELRHLKILHVKS----NLTKVPSNITDVAPHLTKLVIHNDgtkllvlnslkKM 634
Cdd:cd21340   67 LVNLKKLYLGGNRIS---VVEGLENLTNLEELHIENQRLppgeKLTFDPRSLAALSNSLRVLNISGN-----------NI 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 635 MNVAELElqnceleriphaifSLSNLQELDLKSNNIRTIEEII-SFQHLKRLTCLKLWHNKIVTIP----PSITHVKNLE 709
Cdd:cd21340  133 DSLEPLA--------------PLRNLEQLDASNNQISDLEELLdLLSSWPSLRELDLTGNPVCKKPkyrdKIILASKSLE 198


                 ..
gi 197333706 710 SL 711
Cdd:cd21340  199 VL 200
LRR_8 pfam13855
Leucine rich repeat;
752-808 6.86e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 6.86e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 197333706  752 QNLQHLHITGNKVDILPKQLFK-CIKLRTLNLGQNCITSLPEKVGQ-LSQLTQLELKGN 808
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSPGAFSgLPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
707-764 1.11e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 1.11e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706  707 NLESLYFSNNKLESLPVAVFS-LQKLRCLDVSYNNISMI-PIEIGLLQNLQHLHITGNKV 764
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
628-827 1.19e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 49.01  E-value: 1.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 628 LNSLKKMMNVAE---LELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEeiISFQHLKRLTCLKLWHNKIVTIPPSITH 704
Cdd:PRK15387 199 LNNGNAVLNVGEsglTTLPDCLPAHITTLVIPDNNLTSLPALPPELRTLE--VSGNQLTSLPVLPPGLLELSIFSNPLTH 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 705 VKNLES----LYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEI--------------GLLQNLQHLHITGNKVDI 766
Cdd:PRK15387 277 LPALPSglckLWIFGNQLTSLPVLPPGLQELSVSDNQLASLPALPSELcklwaynnqltslpTLPSGLQELSVSDNQLAS 356

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 197333706 767 LPKQLFKCIKLRTLNlgqNCITSLPekvGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSG 827
Cdd:PRK15387 357 LPTLPSELYKLWAYN---NRLTSLP---ALPSGLKELIVSGNRLTSLPVLPSELKELMVSG 411
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 484-715 2.48e-05

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 48.33  E-value: 2.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706  484 DAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAE-IPAWVYL---- 558
Cdd:PLN03210  628 DGVHSLTGLRNIDLRGSKNLKEIPDLSMATNLETLKLSDCSSLVELPSSIQYLNKLEDLDMSRCENLEiLPTGINLksly 707

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706  559 ---------LK-------NLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLTKVPSN--ITDVAPHLTKLVIHN 620
Cdd:PLN03210  708 rlnlsgcsrLKsfpdistNISWLDLDETAIEEFPSNLRLENLDELILCEMKSEKLWERVQPLTplMTMLSPSLTRLFLSD 787

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706  621 DGTKLLVLNSLKKMMNVAELELQNC-ELERIPHAIfSLSNLQELDLK-----------SNNI------RT-IEE----II 677
Cdd:PLN03210  788 IPSLVELPSSIQNLHKLEHLEIENCiNLETLPTGI-NLESLESLDLSgcsrlrtfpdiSTNIsdlnlsRTgIEEvpwwIE 866

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 197333706  678 SFQHLKRLTCLKLwhNKIVTIPPSITHVKNLESLYFSN 715
Cdd:PLN03210  867 KFSNLSFLDMNGC--NNLQRVSLNISKLKHLETVDFSD 902
PLN03150 PLN03150
hypothetical protein; Provisional
 698-762 3.05e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.50  E-value: 3.05e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 197333706 698 IPPSITHVKNLESLYFSNNKLE-SLPVAVFSLQKLRCLDVSYNNIS-MIPIEIGLLQNLQHLHITGN 762
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGN 500
PLN03150 PLN03150
hypothetical protein; Provisional
 744-818 3.21e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.50  E-value: 3.21e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 197333706 744 IPIEIGLLQNLQHLHITGNKVD-ILPKQLFKCIKLRTLNLGQNCIT-SLPEKVGQLSQLTQLELKGNCLD-RLPAQLG 818
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSgRVPAALG 511
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 636-771 1.18e-04

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 46.02  E-value: 1.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706  636 NVAELELQNCELERIPHAIFSLSNLQELDL-KSNNIRTIEEIISFQHLKRL---TCLKLwhnkiVTIPPSITHVKNLESL 711
Cdd:PLN03210  612 NLVKLQMQGSKLEKLWDGVHSLTGLRNIDLrGSKNLKEIPDLSMATNLETLklsDCSSL-----VELPSSIQYLNKLEDL 686

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 197333706  712 YFSN-NKLESLPVAVfSLQKLRCLDVsyNNISMIPIEIGLLQNLQHLHITGNKVDILPKQL 771
Cdd:PLN03210  687 DMSRcENLEILPTGI-NLKSLYRLNL--SGCSRLKSFPDISTNISWLDLDETAIEEFPSNL 744
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 582-816 1.42e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.04  E-value: 1.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 582 ESLRELRHLKILHVKSNLTKVpSNITDVAPHLTklviHNDGTKLLVLnslkKMMNVAELELQnceLERIPHAIFSLSNLQ 661
Cdd:cd00116   17 ELLPKLLCLQVLRLEGNTLGE-EAAKALASALR----PQPSLKELCL----SLNETGRIPRG---LQSLLQGLTKGCGLQ 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 662 ELDLkSNN---IRTIEEIISFQHLKRLTCLKLWHNKI-----VTIPPSITHVK-NLESLYFSNNKL-----ESLPVAVFS 727
Cdd:cd00116   85 ELDL-SDNalgPDGCGVLESLLRSSSLQELKLNNNGLgdrglRLLAKGLKDLPpALEKLVLGRNRLegascEALAKALRA 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 728 LQKLRCLDVSYNNISMIPIEI---GL--LQNLQHLHITGNKV-DILPKQLFKCIK----LRTLNLGQNCITS------LP 791
Cdd:cd00116  164 NRDLKELNLANNGIGDAGIRAlaeGLkaNCNLEVLDLNNNGLtDEGASALAETLAslksLEVLNLGDNNLTDagaaalAS 243

                        250       260
                 ....*....|....*....|....*
gi 197333706 792 EKVGQLSQLTQLELKGNCLDRLPAQ 816
Cdd:cd00116  244 ALLSPNISLLTLSLSCNDITDDGAK 268
LRR_9 pfam14580
Leucine-rich repeat;
639-745 1.80e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 43.21  E-value: 1.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706  639 ELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEeiiSFQHLKRLTCLKLWHNKIVTIPPSITHV-KNLESLYFSNNK 717
Cdd:pfam14580  23 ELDLRGYKIPIIENLGATLDQFDTIDFSDNEIRKLD---GFPLLRRLKTLLLNNNRICRIGEGLGEAlPNLTELILTNNN 99

                          90       100       110
                  ....*....|....*....|....*....|..
gi 197333706  718 LESL----PVAvfSLQKLRCLDVSYNNISMIP 745
Cdd:pfam14580 100 LQELgdldPLA--SLKKLTFLSLLRNPVTNKP 129
LRR_8 pfam13855
Leucine rich repeat;
729-785 1.22e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 1.22e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 197333706  729 QKLRCLDVSYNNISMIPIEIGL-LQNLQHLHITGNKVDILPKQLFKCI-KLRTLNLGQN 785
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSPGAFSGLpSLRYLDLSGN 59
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 706-740 3.63e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.07  E-value: 3.63e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 197333706  706 KNLESLYFSNNKLESLPVAVfSLQKLRCLDVSYNN 740
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLA-KLPNLETLDLSGNN 34
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 509-695 5.06e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.03  E-value: 5.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 509 ISQMTNLQELHLCHCPakVEQTAFSFLRDHLRclhvkftDVAEipawvyllkNLRELYLIGNlNSENNKMIGL-ESLREL 587
Cdd:cd00116  104 LLRSSSLQELKLNNNG--LGDRGLRLLAKGLK-------DLPP---------ALEKLVLGRN-RLEGASCEALaKALRAN 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197333706 588 RHLKILHVKSNltkvpsNITDVA-PHLTKLVIHNDGTKLLVLNSLKkmmnvaeLELQNCELerIPHAIFSLSNLQELDLK 666
Cdd:cd00116  165 RDLKELNLANN------GIGDAGiRALAEGLKANCNLEVLDLNNNG-------LTDEGASA--LAETLASLKSLEVLNLG 229

                        170       180       190
                 ....*....|....*....|....*....|....
gi 197333706 667 SNNIRT--IEEIISfQHLKRLTCLK---LWHNKI 695
Cdd:cd00116  230 DNNLTDagAAALAS-ALLSPNISLLtlsLSCNDI 262
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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