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Conserved domains on  [gi|206725428|ref|NP_001128687|]
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zinc finger and SCAN domain-containing protein 31 isoform 1 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein; zinc finger and BTB domain-containing protein( domain architecture ID 12210801)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation; zinc finger and BTB (BR-C, ttk and bab)/POZ (Pox virus and Zinc finger) domain-containing protein may be involved in transcriptional regulation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SCAN smart00431
leucine rich region;
35-146 2.59e-63

leucine rich region;


:

Pssm-ID: 128708 [Multi-domain]  Cd Length: 113  Bit Score: 198.68  E-value: 2.59e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725428    35 QEASRQLFRQFCYQETPGPREALSRLRELCHQWLRPEIHTKEQILELLVLEQFLTILPEELQAWVREHHPESGEEAVAVV 114
Cdd:smart00431   1 PEIFRQRFRQFRYQETSGPREALSRLRELCRQWLRPELHTKEQILELLVLEQFLTILPGELQAWVREHHPESGEEAVTLL 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 206725428   115 EDLEQELSEPGNQAPDHEHGHsEVLLEDVEHL 146
Cdd:smart00431  81 EDLERELDEPGQQVSAHVHGQ-EVLLEKMVPL 111
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
156-397 9.34e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.93  E-value: 9.34e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725428 156 QLQPMVTQLRYESFCLHQFQEQDGESIPENQELA-SKQEILKEMEHLGDSKLQRDVSLDSKYRETCKRDSKAEKQQAHST 234
Cdd:COG5048  201 ENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQlSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDS 280

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725428 235 GER-----RHRCNECGKSFTKSSVLIEHQR--IHTGE--KPYECEE--CGKAFSRRSSLNEHRRSHTGEKPYQCKEC--- 300
Cdd:COG5048  281 SSEkgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnss 360

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725428 301 ----GKAFSASNGLTRHRRIHTGEKPYECKV--CGKAFLLSSCLVQHQRIHTGEKRYQCR--ECGKAFIQNAGLFQHLRV 372
Cdd:COG5048  361 skfsPLLNNEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKI 440

                        250       260
                 ....*....|....*....|....*
gi 206725428 373 HTgEKPYQCSQCSKLFSKRTLLKKH 397
Cdd:COG5048  441 HT-NHAPLLCSILKSFRRDLDLSNH 464
 
Name Accession Description Interval E-value
SCAN smart00431
leucine rich region;
35-146 2.59e-63

leucine rich region;


Pssm-ID: 128708 [Multi-domain]  Cd Length: 113  Bit Score: 198.68  E-value: 2.59e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725428    35 QEASRQLFRQFCYQETPGPREALSRLRELCHQWLRPEIHTKEQILELLVLEQFLTILPEELQAWVREHHPESGEEAVAVV 114
Cdd:smart00431   1 PEIFRQRFRQFRYQETSGPREALSRLRELCRQWLRPELHTKEQILELLVLEQFLTILPGELQAWVREHHPESGEEAVTLL 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 206725428   115 EDLEQELSEPGNQAPDHEHGHsEVLLEDVEHL 146
Cdd:smart00431  81 EDLERELDEPGQQVSAHVHGQ-EVLLEKMVPL 111
SCAN pfam02023
SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found ...
 35-123 6.59e-53

SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several pfam00096 proteins. The domain has been shown to be able to mediate homo- and hetero-oligomerization.


Pssm-ID: 460417 [Multi-domain]  Cd Length: 89  Bit Score: 171.13  E-value: 6.59e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725428   35 QEASRQLFRQFCYQETPGPREALSRLRELCHQWLRPEIHTKEQILELLVLEQFLTILPEELQAWVREHHPESGEEAVAVV 114
Cdd:pfam02023   1 PEASRQRFRQFCYQEAEGPREALSQLRELCHQWLRPEKHTKEQILELLVLEQFLTILPEEIQSWVREHHPESGEEAVALA 80


                  ....*....
gi 206725428  115 EDLEQELSE 123
Cdd:pfam02023  81 EDLLLERGE 89
SCAN cd07936
SCAN oligomerization domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 ...
 36-119 1.63e-42

SCAN oligomerization domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several vertebrate proteins that contain C2H2 zinc finger motifs, many of which may be transcription factors playing roles in cell survival and differentiation. This protein-interaction domain is able to mediate homo- and hetero-oligomerization of SCAN-containing proteins. Some SCAN-containing proteins, including those of lower vertebrates, do not contain zinc finger motifs. It has been noted that the SCAN domain resembles a domain-swapped version of the C-terminal domain of the HIV capsid protein. This domain model features elements common to the three general groups of SCAN domains (SCAN-A1, SCAN-A2, and SCAN-B). The SCAND1 protein is truncated at the C-terminus with respect to this model, the SCAND2 protein appears to have a truncated central helix.


Pssm-ID: 153421  Cd Length: 85  Bit Score: 143.94  E-value: 1.63e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725428  36 EASRQLFRQFCYQETPGPREALSRLRELCHQWLRPEIHTKEQILELLVLEQFLTILPEELQAWVREHHPESGEEAVAVVE 115
Cdd:cd07936    2 ETYRQRFRAFQYQEASGPREALQRLRELCRQWLRPEIHTKEQILELLVLEQFLIILPPEVQAWVRERKPESGEEAATLAE 81


                 ....
gi 206725428 116 DLEQ 119
Cdd:cd07936   82 DLLA 85
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
156-397 9.34e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.93  E-value: 9.34e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725428 156 QLQPMVTQLRYESFCLHQFQEQDGESIPENQELA-SKQEILKEMEHLGDSKLQRDVSLDSKYRETCKRDSKAEKQQAHST 234
Cdd:COG5048  201 ENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQlSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDS 280

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725428 235 GER-----RHRCNECGKSFTKSSVLIEHQR--IHTGE--KPYECEE--CGKAFSRRSSLNEHRRSHTGEKPYQCKEC--- 300
Cdd:COG5048  281 SSEkgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnss 360

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725428 301 ----GKAFSASNGLTRHRRIHTGEKPYECKV--CGKAFLLSSCLVQHQRIHTGEKRYQCR--ECGKAFIQNAGLFQHLRV 372
Cdd:COG5048  361 skfsPLLNNEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKI 440

                        250       260
                 ....*....|....*....|....*
gi 206725428 373 HTgEKPYQCSQCSKLFSKRTLLKKH 397
Cdd:COG5048  441 HT-NHAPLLCSILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
310-332 4.46e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 4.46e-05
                          10        20
                  ....*....|....*....|...
gi 206725428  310 LTRHRRIHTGEKPYECKVCGKAF 332
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
mukB PRK04863
chromosome partition protein MukB;
54-201 5.48e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 39.17  E-value: 5.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725428   54 REALSRLRELCH-----QWLRPEIHTKEQILEL-----LVLEQFLTILPEELQAwvREHHPESGEEAVAVVEDLEQELSE 123
Cdd:PRK04863  499 RELLRRLREQRHlaeqlQQLRMRLSELEQRLRQqqraeRLLAEFCKRLGKNLDD--EDELEQLQEELEARLESLSESVSE 576

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725428  124 PGNQAPDHEHgHSEVLLEDVEHLKvKQEPTDIQLQPMVTQLRY---ESF--------CLHQFQEQDGESIPENQELAS-K 191
Cdd:PRK04863  577 ARERRMALRQ-QLEQLQARIQRLA-ARAPAWLAAQDALARLREqsgEEFedsqdvteYMQQLLERERELTVERDELAArK 654

                         170
                  ....*....|
gi 206725428  192 QEILKEMEHL 201
Cdd:PRK04863  655 QALDEEIERL 664
 
Name Accession Description Interval E-value
SCAN smart00431
leucine rich region;
35-146 2.59e-63

leucine rich region;


Pssm-ID: 128708 [Multi-domain]  Cd Length: 113  Bit Score: 198.68  E-value: 2.59e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725428    35 QEASRQLFRQFCYQETPGPREALSRLRELCHQWLRPEIHTKEQILELLVLEQFLTILPEELQAWVREHHPESGEEAVAVV 114
Cdd:smart00431   1 PEIFRQRFRQFRYQETSGPREALSRLRELCRQWLRPELHTKEQILELLVLEQFLTILPGELQAWVREHHPESGEEAVTLL 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 206725428   115 EDLEQELSEPGNQAPDHEHGHsEVLLEDVEHL 146
Cdd:smart00431  81 EDLERELDEPGQQVSAHVHGQ-EVLLEKMVPL 111
SCAN pfam02023
SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found ...
 35-123 6.59e-53

SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several pfam00096 proteins. The domain has been shown to be able to mediate homo- and hetero-oligomerization.


Pssm-ID: 460417 [Multi-domain]  Cd Length: 89  Bit Score: 171.13  E-value: 6.59e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725428   35 QEASRQLFRQFCYQETPGPREALSRLRELCHQWLRPEIHTKEQILELLVLEQFLTILPEELQAWVREHHPESGEEAVAVV 114
Cdd:pfam02023   1 PEASRQRFRQFCYQEAEGPREALSQLRELCHQWLRPEKHTKEQILELLVLEQFLTILPEEIQSWVREHHPESGEEAVALA 80


                  ....*....
gi 206725428  115 EDLEQELSE 123
Cdd:pfam02023  81 EDLLLERGE 89
SCAN cd07936
SCAN oligomerization domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 ...
 36-119 1.63e-42

SCAN oligomerization domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several vertebrate proteins that contain C2H2 zinc finger motifs, many of which may be transcription factors playing roles in cell survival and differentiation. This protein-interaction domain is able to mediate homo- and hetero-oligomerization of SCAN-containing proteins. Some SCAN-containing proteins, including those of lower vertebrates, do not contain zinc finger motifs. It has been noted that the SCAN domain resembles a domain-swapped version of the C-terminal domain of the HIV capsid protein. This domain model features elements common to the three general groups of SCAN domains (SCAN-A1, SCAN-A2, and SCAN-B). The SCAND1 protein is truncated at the C-terminus with respect to this model, the SCAND2 protein appears to have a truncated central helix.


Pssm-ID: 153421  Cd Length: 85  Bit Score: 143.94  E-value: 1.63e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725428  36 EASRQLFRQFCYQETPGPREALSRLRELCHQWLRPEIHTKEQILELLVLEQFLTILPEELQAWVREHHPESGEEAVAVVE 115
Cdd:cd07936    2 ETYRQRFRAFQYQEASGPREALQRLRELCRQWLRPEIHTKEQILELLVLEQFLIILPPEVQAWVRERKPESGEEAATLAE 81


                 ....
gi 206725428 116 DLEQ 119
Cdd:cd07936   82 DLLA 85
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
156-397 9.34e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.93  E-value: 9.34e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725428 156 QLQPMVTQLRYESFCLHQFQEQDGESIPENQELA-SKQEILKEMEHLGDSKLQRDVSLDSKYRETCKRDSKAEKQQAHST 234
Cdd:COG5048  201 ENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQlSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDS 280

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725428 235 GER-----RHRCNECGKSFTKSSVLIEHQR--IHTGE--KPYECEE--CGKAFSRRSSLNEHRRSHTGEKPYQCKEC--- 300
Cdd:COG5048  281 SSEkgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnss 360

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725428 301 ----GKAFSASNGLTRHRRIHTGEKPYECKV--CGKAFLLSSCLVQHQRIHTGEKRYQCR--ECGKAFIQNAGLFQHLRV 372
Cdd:COG5048  361 skfsPLLNNEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKI 440

                        250       260
                 ....*....|....*....|....*
gi 206725428 373 HTgEKPYQCSQCSKLFSKRTLLKKH 397
Cdd:COG5048  441 HT-NHAPLLCSILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
220-406 1.20e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.55  E-value: 1.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725428 220 CKRDSKAEKQQAHSTGERRHRCNECGKSFTKSSVLIEHQRIHTGE-------KPYECEECGKAFSRRSSLNEHRRS--HT 290
Cdd:COG5048  236 SPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHS 315

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725428 291 GE--KPYQCKE--CGKAFSASNGLTRHRRIHTGEKPYECK--VCGKAF--LLSSCLVQHQRIHTGEKRYQCRE-----CG 357
Cdd:COG5048  316 GEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFspLLNNEPPQSLQQYKDLKNDKKSEtlsnsCI 395

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 206725428 358 KAFIQNAGLFQHLRVHTGEKPYQC--SQCSKLFSKRTLLKKHQKIHTGERP 406
Cdd:COG5048  396 RNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAP 446
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
265-325 2.30e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 2.30e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 206725428 265 KPYECEECGKAFSRRSSLNEHRRSHTGEKPYQCKECGKAFSASNG--LTRHRRIHTGEKPYEC 325
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSDLN 94
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
207-294 2.64e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 2.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725428 207 QRDVSLDSKYRETCKRDSKAEKQQahstgERRHRCNECGKSFTKSSVLIEHQRIHTGEKPYEC--EECGKAFSRRSSLNE 284
Cdd:COG5048    7 QSSSSNNSVLSSTPKSTLKSLSNA-----PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSR 81

                         90
                 ....*....|
gi 206725428 285 HRRSHTGEKP 294
Cdd:COG5048   82 HLRTHHNNPS 91
zf-H2C2_2 pfam13465
Zinc-finger double domain;
310-332 4.46e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 4.46e-05
                          10        20
                  ....*....|....*....|...
gi 206725428  310 LTRHRRIHTGEKPYECKVCGKAF 332
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
254-278 4.64e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 4.64e-05
                          10        20
                  ....*....|....*....|....*
gi 206725428  254 LIEHQRIHTGEKPYECEECGKAFSR 278
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
281-305 4.87e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 4.87e-05
                          10        20
                  ....*....|....*....|....*
gi 206725428  281 SLNEHRRSHTGEKPYQCKECGKAFS 305
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
338-362 1.52e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.52e-04
                          10        20
                  ....*....|....*....|....*
gi 206725428  338 LVQHQRIHTGEKRYQCRECGKAFIQ 362
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 263-314 2.35e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 2.35e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 206725428 263 GEKPYECE--ECGKAFSRRSSLNEHRR---------------SHTG----EKPYQCKECGKAFSASNGLTRHR 314
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLhghqnqklhenpspeKMNIfsakDKPYRCEVCDKRYKNLNGLKYHR 418
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
293-346 2.58e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 2.58e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 206725428 293 KPYQCKECGKAFSASNGLTRHRRIHTGEKPYECKV--CGKAFLLSSCLVQHQRIHT 346
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHH 87
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 267-289 5.71e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 5.71e-04
                          10        20
                  ....*....|....*....|...
gi 206725428  267 YECEECGKAFSRRSSLNEHRRSH 289
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
366-390 8.98e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 8.98e-04
                          10        20
                  ....*....|....*....|....*
gi 206725428  366 LFQHLRVHTGEKPYQCSQCSKLFSK 390
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 291-374 2.14e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 2.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725428 291 GEKPYQCK--ECGKAFSASNGLTRHRRI-HTGEKPYEckvcgkafllSSCLVQHQRIHTGEKRYQCRECGKAFIQNAGLF 367
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHE----------NPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                 ....*..
gi 206725428 368 QHlRVHT 374
Cdd:COG5189  416 YH-RKHS 421
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 295-317 4.84e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 4.84e-03
                          10        20
                  ....*....|....*....|...
gi 206725428  295 YQCKECGKAFSASNGLTRHRRIH 317
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 239-261 4.99e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 4.99e-03
                          10        20
                  ....*....|....*....|...
gi 206725428  239 HRCNECGKSFTKSSVLIEHQRIH 261
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
mukB PRK04863
chromosome partition protein MukB;
54-201 5.48e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 39.17  E-value: 5.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725428   54 REALSRLRELCH-----QWLRPEIHTKEQILEL-----LVLEQFLTILPEELQAwvREHHPESGEEAVAVVEDLEQELSE 123
Cdd:PRK04863  499 RELLRRLREQRHlaeqlQQLRMRLSELEQRLRQqqraeRLLAEFCKRLGKNLDD--EDELEQLQEELEARLESLSESVSE 576

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725428  124 PGNQAPDHEHgHSEVLLEDVEHLKvKQEPTDIQLQPMVTQLRY---ESF--------CLHQFQEQDGESIPENQELAS-K 191
Cdd:PRK04863  577 ARERRMALRQ-QLEQLQARIQRLA-ARAPAWLAAQDALARLREqsgEEFedsqdvteYMQQLLERERELTVERDELAArK 654

                         170
                  ....*....|
gi 206725428  192 QEILKEMEHL 201
Cdd:PRK04863  655 QALDEEIERL 664
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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