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Conserved domains on  [gi|209862879|ref|NP_001129511|]
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NIF3-like protein 1 isoform 1 [Homo sapiens]

Protein Classification

Nif3-like dinuclear metal center hexameric protein( domain architecture ID 10484881)

Nif3-like dinuclear metal center hexameric protein may be a prohibitive factor restricting the infestation of certain pathogens

CATH:  3.40.1390.30
Gene Ontology:  GO:0046872

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
NIF3 pfam01784
NIF3 (NGG1p interacting factor 3); This family contains several NIF3 (NGG1p interacting factor ...
33-354 2.56e-77

NIF3 (NGG1p interacting factor 3); This family contains several NIF3 (NGG1p interacting factor 3) protein homologs. NIF3 interacts with the yeast transcriptional coactivator NGG1p which is part of the ADA complex, the exact function of this interaction is unknown.


:

Pssm-ID: 426431  Cd Length: 236  Bit Score: 238.29  E-value: 2.56e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209862879   33 LLSSLNDFASLSFAESWDNVGLLVEpSPPHTVNTLFLTNDLTEEVMEEVLQKKADLILSYHPPIFRPMKRITWNTWKERL 112
Cdd:pfam01784   2 IIELLEEIAPPELAEDWDNVGLQVG-DPENEVTKILVALDATEEVIEEAIENGADLIITHHPLIFRPLKSLTGDDPKGRR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209862879  113 VIRALENRVGIYSPHTAYDAAPQGVNNWLAKGLGACTSRPIHPSKApnyptegnhrvefnvnytqdldkvmsavkgidgv 192
Cdd:pfam01784  81 IKKLIKNNISLYSAHTNLDAAPGGVNDWLAELLGLESIEPLEPTEE---------------------------------- 126
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209862879  193 svtsfsartgneeqtrinlnctqkalmqvvdflsrnkqlyqkteilslekplllHTGMGRLCTLDESVSLATMIDRIKRH 272
Cdd:pfam01784 127 ------------------------------------------------------GEGLGRIGELPEPMSLEELAAKVKEK 152
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209862879  273 LKLSHIRLALGvgrtLESQVKVVALCAGSGSSVL---QGVEADLYLTGEMSHHDTLDAASQGINVILCEHSNTERGFLSD 349
Cdd:pfam01784 153 LGLEGVRVVGD----LDKPIKKVAICGGSGSSLIdeaKAKGADVLITGDVKYHDALDAQEKGINLIDAGHYATERFGLEA 228

                  ....*
gi 209862879  350 LRDML 354
Cdd:pfam01784 229 LAELL 233
 
Name Accession Description Interval E-value
NIF3 pfam01784
NIF3 (NGG1p interacting factor 3); This family contains several NIF3 (NGG1p interacting factor ...
33-354 2.56e-77

NIF3 (NGG1p interacting factor 3); This family contains several NIF3 (NGG1p interacting factor 3) protein homologs. NIF3 interacts with the yeast transcriptional coactivator NGG1p which is part of the ADA complex, the exact function of this interaction is unknown.


Pssm-ID: 426431  Cd Length: 236  Bit Score: 238.29  E-value: 2.56e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209862879   33 LLSSLNDFASLSFAESWDNVGLLVEpSPPHTVNTLFLTNDLTEEVMEEVLQKKADLILSYHPPIFRPMKRITWNTWKERL 112
Cdd:pfam01784   2 IIELLEEIAPPELAEDWDNVGLQVG-DPENEVTKILVALDATEEVIEEAIENGADLIITHHPLIFRPLKSLTGDDPKGRR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209862879  113 VIRALENRVGIYSPHTAYDAAPQGVNNWLAKGLGACTSRPIHPSKApnyptegnhrvefnvnytqdldkvmsavkgidgv 192
Cdd:pfam01784  81 IKKLIKNNISLYSAHTNLDAAPGGVNDWLAELLGLESIEPLEPTEE---------------------------------- 126
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209862879  193 svtsfsartgneeqtrinlnctqkalmqvvdflsrnkqlyqkteilslekplllHTGMGRLCTLDESVSLATMIDRIKRH 272
Cdd:pfam01784 127 ------------------------------------------------------GEGLGRIGELPEPMSLEELAAKVKEK 152
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209862879  273 LKLSHIRLALGvgrtLESQVKVVALCAGSGSSVL---QGVEADLYLTGEMSHHDTLDAASQGINVILCEHSNTERGFLSD 349
Cdd:pfam01784 153 LGLEGVRVVGD----LDKPIKKVAICGGSGSSLIdeaKAKGADVLITGDVKYHDALDAQEKGINLIDAGHYATERFGLEA 228

                  ....*
gi 209862879  350 LRDML 354
Cdd:pfam01784 229 LAELL 233
NIF3 COG0327
Putative GTP cyclohydrolase 1 type 2, NIF3 family [Coenzyme transport and metabolism]; ...
28-373 2.90e-56

Putative GTP cyclohydrolase 1 type 2, NIF3 family [Coenzyme transport and metabolism]; Putative GTP cyclohydrolase 1 type 2, NIF3 family is part of the Pathway/BioSystem: Folate biosynthesis


Pssm-ID: 440096  Cd Length: 254  Bit Score: 184.58  E-value: 2.90e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209862879  28 MDLKALLSSLNDFASLSFAESWDNVGLLV-EPSPPhtVNTLFLTNDLTEEVMEEVLQKKADLILSYHPPIFRPMKRITWN 106
Cdd:COG0327    1 MTLSELVAALEELLPPALAESWDPNGLQVgEGRAE--VTRIVTAVDATQAVIEEAIEAGADLLIVHHPLFWKGEDSITAG 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209862879 107 TWKERLVIRALENRVGIYSPHTAYDAAPQ-GVNNWLAKGLGACTSRPIHPSKApnyptegnhrvefnvnytqdldkvmsa 185
Cdd:COG0327   79 TVKGRRLALLIKNDIALYAAHTPLDAHPElGNNAQLARLLGLEDVEPLGPSGG--------------------------- 131
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209862879 186 vkgidgvsvtsfsartgneeqtrinlnctqkalmqvvdflsrnkqlyqkteilslekplllhTGMGRLCTLDESVSLATM 265
Cdd:COG0327  132 --------------------------------------------------------------EGLGRIGELPEPMTLEEL 149
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209862879 266 IDRIKRHLKLSHIRLalgVGRtLESQVKVVALCAGSGSSVLQGVE---ADLYLTGEMSHHDTLDAASQGINVILCEHSNT 342
Cdd:COG0327  150 AARVKEALGLRGVRV---VGD-PDRPIRRVAICTGSGQSLIEEAAaagADAYITGEIKEHTAHDAREQGIALIDAGHYAT 225
                        330       340       350
                 ....*....|....*....|....*....|.
gi 209862879 343 ERGFLSDLRDMLDSHLEnkINIILSETDRDP 373
Cdd:COG0327  226 ERPGVQALAEWLAEAFG--LEVEFIDIDNPP 254
YbgI_SA1388 TIGR00486
dinuclear metal center protein, YbgI/SA1388 family; The characterization of this family of ...
28-373 3.56e-41

dinuclear metal center protein, YbgI/SA1388 family; The characterization of this family of uncharacterized proteins as orthologous is tentative. Members are found in all three domains of life. Several members (from Bacillus subtilis, Listeria monocytogenes, and Mycobacterium tuberculosis - all classified as Firmicutes within the Eubacteria) share a long insert relative to other members. [Unknown function, General]


Pssm-ID: 213534  Cd Length: 249  Bit Score: 145.23  E-value: 3.56e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209862879   28 MDLKALLSSLNDFASLSFAESWDNVGLLVEpSPPHTVNTLFLTNDLTEEVMEEVLQKKADLILSYHPPIFRPMKRITWNT 107
Cdd:TIGR00486   1 MNLDELIQLINRFLPKELAEDGDNNGLQVG-SGNEEVKKVVVAVDASESVADEAVRLGADLIITHHPLIWKPLKRLIRGI 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209862879  108 WKERLVIrALENRVGIYSPHTAYDAAPQGVNNWLAKGLGActsrpihpskapnyptegnhrvefnvnytqdldkvmsavk 187
Cdd:TIGR00486  80 KPGRLKI-LLQNDISLYSAHTNLDAHDGGNNDALARALGL---------------------------------------- 118
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209862879  188 gidgvsvtsfsartgneeqtrinlnctqkalmqvvdflsrnkqlyqkTEILSLEKPlllhtGMGRLCTLDESVSLATMID 267
Cdd:TIGR00486 119 -----------------------------------------------ENPKEFEDY-----GLGRVGEFKAPIESLEEVL 146
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209862879  268 RIKRHLKLSHIRlalgVGRTLESQVKVVALCAGSGSS-----VLQGVeaDLYLTGEMSHHDTLDAASQGINVILCEHSNT 342
Cdd:TIGR00486 147 EIKKVLNVKPLL----VVKNGPEYVKKVAVVSGSGLSfimkaLREGV--DAYITGDLSHHTAHLARELGLNVIDAGHYAT 220
                         330       340       350
                  ....*....|....*....|....*....|.
gi 209862879  343 ERGFLSDLRDMLdsHLENKINIILSETDRDP 373
Cdd:TIGR00486 221 ERGGLRKLMEDL--NENEGLEVVFSDIPTNA 249
PRK10799 PRK10799
type 2 GTP cyclohydrolase I;
225-357 1.53e-04

type 2 GTP cyclohydrolase I;


Pssm-ID: 182741  Cd Length: 247  Bit Score: 42.82  E-value: 1.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209862879 225 LSRNKQLYQKTEI--LSLEKPLLLHTgmgrlcTLDESVSLATMIDRIKRHLKlshiRLALGVGRTLESQVKVVALCAGSG 302
Cdd:PRK10799 106 LGNNAQLAALLGItvMGEIEPLVPWG------ELTMPVPGLELASWIEARLG----RKPLWCGDTGPEVVQRVAWCTGGG 175
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 209862879 303 SSVLQ-----GVEAdlYLTGEMSHHDTLDAASQGINVILCEHSNTERGFLSDLRDMLDSH 357
Cdd:PRK10799 176 QSFIDsaarfGVDA--FITGEVSEQTIHSAREQGLHFYAAGHHATERGGIRALSEWLNEN 233
 
Name Accession Description Interval E-value
NIF3 pfam01784
NIF3 (NGG1p interacting factor 3); This family contains several NIF3 (NGG1p interacting factor ...
33-354 2.56e-77

NIF3 (NGG1p interacting factor 3); This family contains several NIF3 (NGG1p interacting factor 3) protein homologs. NIF3 interacts with the yeast transcriptional coactivator NGG1p which is part of the ADA complex, the exact function of this interaction is unknown.


Pssm-ID: 426431  Cd Length: 236  Bit Score: 238.29  E-value: 2.56e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209862879   33 LLSSLNDFASLSFAESWDNVGLLVEpSPPHTVNTLFLTNDLTEEVMEEVLQKKADLILSYHPPIFRPMKRITWNTWKERL 112
Cdd:pfam01784   2 IIELLEEIAPPELAEDWDNVGLQVG-DPENEVTKILVALDATEEVIEEAIENGADLIITHHPLIFRPLKSLTGDDPKGRR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209862879  113 VIRALENRVGIYSPHTAYDAAPQGVNNWLAKGLGACTSRPIHPSKApnyptegnhrvefnvnytqdldkvmsavkgidgv 192
Cdd:pfam01784  81 IKKLIKNNISLYSAHTNLDAAPGGVNDWLAELLGLESIEPLEPTEE---------------------------------- 126
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209862879  193 svtsfsartgneeqtrinlnctqkalmqvvdflsrnkqlyqkteilslekplllHTGMGRLCTLDESVSLATMIDRIKRH 272
Cdd:pfam01784 127 ------------------------------------------------------GEGLGRIGELPEPMSLEELAAKVKEK 152
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209862879  273 LKLSHIRLALGvgrtLESQVKVVALCAGSGSSVL---QGVEADLYLTGEMSHHDTLDAASQGINVILCEHSNTERGFLSD 349
Cdd:pfam01784 153 LGLEGVRVVGD----LDKPIKKVAICGGSGSSLIdeaKAKGADVLITGDVKYHDALDAQEKGINLIDAGHYATERFGLEA 228

                  ....*
gi 209862879  350 LRDML 354
Cdd:pfam01784 229 LAELL 233
NIF3 COG0327
Putative GTP cyclohydrolase 1 type 2, NIF3 family [Coenzyme transport and metabolism]; ...
28-373 2.90e-56

Putative GTP cyclohydrolase 1 type 2, NIF3 family [Coenzyme transport and metabolism]; Putative GTP cyclohydrolase 1 type 2, NIF3 family is part of the Pathway/BioSystem: Folate biosynthesis


Pssm-ID: 440096  Cd Length: 254  Bit Score: 184.58  E-value: 2.90e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209862879  28 MDLKALLSSLNDFASLSFAESWDNVGLLV-EPSPPhtVNTLFLTNDLTEEVMEEVLQKKADLILSYHPPIFRPMKRITWN 106
Cdd:COG0327    1 MTLSELVAALEELLPPALAESWDPNGLQVgEGRAE--VTRIVTAVDATQAVIEEAIEAGADLLIVHHPLFWKGEDSITAG 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209862879 107 TWKERLVIRALENRVGIYSPHTAYDAAPQ-GVNNWLAKGLGACTSRPIHPSKApnyptegnhrvefnvnytqdldkvmsa 185
Cdd:COG0327   79 TVKGRRLALLIKNDIALYAAHTPLDAHPElGNNAQLARLLGLEDVEPLGPSGG--------------------------- 131
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209862879 186 vkgidgvsvtsfsartgneeqtrinlnctqkalmqvvdflsrnkqlyqkteilslekplllhTGMGRLCTLDESVSLATM 265
Cdd:COG0327  132 --------------------------------------------------------------EGLGRIGELPEPMTLEEL 149
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209862879 266 IDRIKRHLKLSHIRLalgVGRtLESQVKVVALCAGSGSSVLQGVE---ADLYLTGEMSHHDTLDAASQGINVILCEHSNT 342
Cdd:COG0327  150 AARVKEALGLRGVRV---VGD-PDRPIRRVAICTGSGQSLIEEAAaagADAYITGEIKEHTAHDAREQGIALIDAGHYAT 225
                        330       340       350
                 ....*....|....*....|....*....|.
gi 209862879 343 ERGFLSDLRDMLDSHLEnkINIILSETDRDP 373
Cdd:COG0327  226 ERPGVQALAEWLAEAFG--LEVEFIDIDNPP 254
YbgI_SA1388 TIGR00486
dinuclear metal center protein, YbgI/SA1388 family; The characterization of this family of ...
28-373 3.56e-41

dinuclear metal center protein, YbgI/SA1388 family; The characterization of this family of uncharacterized proteins as orthologous is tentative. Members are found in all three domains of life. Several members (from Bacillus subtilis, Listeria monocytogenes, and Mycobacterium tuberculosis - all classified as Firmicutes within the Eubacteria) share a long insert relative to other members. [Unknown function, General]


Pssm-ID: 213534  Cd Length: 249  Bit Score: 145.23  E-value: 3.56e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209862879   28 MDLKALLSSLNDFASLSFAESWDNVGLLVEpSPPHTVNTLFLTNDLTEEVMEEVLQKKADLILSYHPPIFRPMKRITWNT 107
Cdd:TIGR00486   1 MNLDELIQLINRFLPKELAEDGDNNGLQVG-SGNEEVKKVVVAVDASESVADEAVRLGADLIITHHPLIWKPLKRLIRGI 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209862879  108 WKERLVIrALENRVGIYSPHTAYDAAPQGVNNWLAKGLGActsrpihpskapnyptegnhrvefnvnytqdldkvmsavk 187
Cdd:TIGR00486  80 KPGRLKI-LLQNDISLYSAHTNLDAHDGGNNDALARALGL---------------------------------------- 118
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209862879  188 gidgvsvtsfsartgneeqtrinlnctqkalmqvvdflsrnkqlyqkTEILSLEKPlllhtGMGRLCTLDESVSLATMID 267
Cdd:TIGR00486 119 -----------------------------------------------ENPKEFEDY-----GLGRVGEFKAPIESLEEVL 146
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209862879  268 RIKRHLKLSHIRlalgVGRTLESQVKVVALCAGSGSS-----VLQGVeaDLYLTGEMSHHDTLDAASQGINVILCEHSNT 342
Cdd:TIGR00486 147 EIKKVLNVKPLL----VVKNGPEYVKKVAVVSGSGLSfimkaLREGV--DAYITGDLSHHTAHLARELGLNVIDAGHYAT 220
                         330       340       350
                  ....*....|....*....|....*....|.
gi 209862879  343 ERGFLSDLRDMLdsHLENKINIILSETDRDP 373
Cdd:TIGR00486 221 ERGGLRKLMEDL--NENEGLEVVFSDIPTNA 249
PRK10799 PRK10799
type 2 GTP cyclohydrolase I;
225-357 1.53e-04

type 2 GTP cyclohydrolase I;


Pssm-ID: 182741  Cd Length: 247  Bit Score: 42.82  E-value: 1.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209862879 225 LSRNKQLYQKTEI--LSLEKPLLLHTgmgrlcTLDESVSLATMIDRIKRHLKlshiRLALGVGRTLESQVKVVALCAGSG 302
Cdd:PRK10799 106 LGNNAQLAALLGItvMGEIEPLVPWG------ELTMPVPGLELASWIEARLG----RKPLWCGDTGPEVVQRVAWCTGGG 175
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 209862879 303 SSVLQ-----GVEAdlYLTGEMSHHDTLDAASQGINVILCEHSNTERGFLSDLRDMLDSH 357
Cdd:PRK10799 176 QSFIDsaarfGVDA--FITGEVSEQTIHSAREQGLHFYAAGHHATERGGIRALSEWLNEN 233
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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