NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2056248647|ref|NP_001129521|]
View 

leishmanolysin-like peptidase isoform 1 precursor [Homo sapiens]

Protein Classification

M8 family metallopeptidase( domain architecture ID 140073)

M8 family metallopeptidase such as the metallo-endopeptidase leishmanolysin, a zinc metallopeptidase with the zinb-binding HEXXH motif and a more C-terminal His residue that is the third ligand of zinc

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Peptidase_M8 super family cl19482
Leishmanolysin;
99-631 8.70e-61

Leishmanolysin;


The actual alignment was detected with superfamily member pfam01457:

Pssm-ID: 388572 [Multi-domain]  Cd Length: 529  Bit Score: 212.40  E-value: 8.70e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056248647  99 LLPEKKNLVKNKLFPQAISYLEKTFQVRRPAGTILLSRQcatnqylrkendphrycTGECaahtkCGPVIVPEEHLqqcr 178
Cdd:pfam01457 105 LTEEKRYILVNYILPQALQLHTERLKVRQVQGTWKVTGM-----------------DGDV-----CGSFKVPPAHV---- 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056248647 179 vyrggkwphgAVGVpdqegiSDADFVLYVGALATErcshENIISYAAYCQQEANmDRPIAGYANLCPNMISTQPQEFvgM 258
Cdd:pfam01457 159 ----------TVGV------SNADFVLYVASVPSE----GGVLAWAFDCQLFPD-GRPAVGVINIPAAYIVSAYDQF--M 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056248647 259 LSTVKHEVIHALGFSAGLFAFYHDKDgnpltsrfadglppfnyslglyqwSDKVVRKverlwdvRDNKivrhtVYLLVTP 338
Cdd:pfam01457 216 VRVVTHELAHALGFSLTFFEMLGIIG------------------------EVKNLRG-------RDYL-----VPVLNSP 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056248647 339 RVVEEARKHFDCPVLEGMELENQGGVGTELNHWEKRLLENEAMTGSHTQNrVLSRITLALMEDTGWYKANYSMAEKLDWG 418
Cdd:pfam01457 260 TVVAKAREQYGCPTLEGLELEDQGGPGTAGSHLKKRNAKDELMAPAVGAG-YYSALTMAVFQDLGFYQADFTKAEVMPWG 338

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056248647 419 RGMGCDFVRKSCkfwidQQRQKRQMLSPYCDtlrSNPLQLTCRQDQRAVAVCNLQKFPKPLPQEYQYFDELSgipaedlp 498
Cdd:pfam01457 339 NNAGCDFLTKKC-----MEDNITQWPEMFCN---STERALRCPTDRLSLGTCSITRHPDPLPTYFQYFTDPS-------- 402

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056248647 499 yYGGSVEIADYCPFSQEFSWHLSGEYQRSSDCRILEnqpeifknygAEKYGPHSVCLiqKSAFVmEKCERKLSYPDWGSg 578
Cdd:pfam01457 403 -LGGGSMFMDYCPYIVGYSNGACNQDPSTASPSLME----------FNVFSDASRCL--DGVFR-PKHSTGITYPYNGL- 467

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2056248647 579 CYQVSCSPQGLKVWVQ---DTSYLCSRAGQVLPVSIQMNGWIHDGNLLCPSCWDFC 631
Cdd:pfam01457 468 CANVRCDRAHHTYSVQvygSSGYVACTPGESVELPTTSAAFVEGGYITCPPYVEVC 523
 
Name Accession Description Interval E-value
Peptidase_M8 pfam01457
Leishmanolysin;
99-631 8.70e-61

Leishmanolysin;


Pssm-ID: 366652 [Multi-domain]  Cd Length: 529  Bit Score: 212.40  E-value: 8.70e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056248647  99 LLPEKKNLVKNKLFPQAISYLEKTFQVRRPAGTILLSRQcatnqylrkendphrycTGECaahtkCGPVIVPEEHLqqcr 178
Cdd:pfam01457 105 LTEEKRYILVNYILPQALQLHTERLKVRQVQGTWKVTGM-----------------DGDV-----CGSFKVPPAHV---- 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056248647 179 vyrggkwphgAVGVpdqegiSDADFVLYVGALATErcshENIISYAAYCQQEANmDRPIAGYANLCPNMISTQPQEFvgM 258
Cdd:pfam01457 159 ----------TVGV------SNADFVLYVASVPSE----GGVLAWAFDCQLFPD-GRPAVGVINIPAAYIVSAYDQF--M 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056248647 259 LSTVKHEVIHALGFSAGLFAFYHDKDgnpltsrfadglppfnyslglyqwSDKVVRKverlwdvRDNKivrhtVYLLVTP 338
Cdd:pfam01457 216 VRVVTHELAHALGFSLTFFEMLGIIG------------------------EVKNLRG-------RDYL-----VPVLNSP 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056248647 339 RVVEEARKHFDCPVLEGMELENQGGVGTELNHWEKRLLENEAMTGSHTQNrVLSRITLALMEDTGWYKANYSMAEKLDWG 418
Cdd:pfam01457 260 TVVAKAREQYGCPTLEGLELEDQGGPGTAGSHLKKRNAKDELMAPAVGAG-YYSALTMAVFQDLGFYQADFTKAEVMPWG 338

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056248647 419 RGMGCDFVRKSCkfwidQQRQKRQMLSPYCDtlrSNPLQLTCRQDQRAVAVCNLQKFPKPLPQEYQYFDELSgipaedlp 498
Cdd:pfam01457 339 NNAGCDFLTKKC-----MEDNITQWPEMFCN---STERALRCPTDRLSLGTCSITRHPDPLPTYFQYFTDPS-------- 402

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056248647 499 yYGGSVEIADYCPFSQEFSWHLSGEYQRSSDCRILEnqpeifknygAEKYGPHSVCLiqKSAFVmEKCERKLSYPDWGSg 578
Cdd:pfam01457 403 -LGGGSMFMDYCPYIVGYSNGACNQDPSTASPSLME----------FNVFSDASRCL--DGVFR-PKHSTGITYPYNGL- 467

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2056248647 579 CYQVSCSPQGLKVWVQ---DTSYLCSRAGQVLPVSIQMNGWIHDGNLLCPSCWDFC 631
Cdd:pfam01457 468 CANVRCDRAHHTYSVQvygSSGYVACTPGESVELPTTSAAFVEGGYITCPPYVEVC 523
PTZ00257 PTZ00257
Glycoprotein GP63 (leishmanolysin); Provisional
 99-517 2.30e-38

Glycoprotein GP63 (leishmanolysin); Provisional


Pssm-ID: 240333  Cd Length: 622  Bit Score: 151.01  E-value: 2.30e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056248647  99 LLPEKKNLVKNKLFPQAISYLEKTFQVRRPAGTILLSRQcatnqylrkendphrycTGECaahtkCGPVIVPEEHLQQcr 178
Cdd:PTZ00257  146 LTEEKRDILVSYLIPQALQLHVERLRVRQVQGSWRVTGM-----------------TGPI-----CGDFKVPKAHVTV-- 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056248647 179 vyrggkwphgavgvpdqeGISDADFVLYVGALATErcshENIISYAAYCQQEANmDRPIAGYANL-CPNMISTQPQefvG 257
Cdd:PTZ00257  202 ------------------GVSNADFVLYVASVPSE----PGVLAWATTCQVFSD-DHPAVGVMNIpAANIVSRYDQ---G 255

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056248647 258 MLSTVKHEVIHALGFS------AGLFAFYHDKDGNPLTSrfadglPPFNYSlglyqwsdkvvrkverlwdvrdnkivrht 331
Cdd:PTZ00257  256 TTRTVTHEVAHALGFSsvffenAGIVKSVTNLRGKPFAA------PVINSS----------------------------- 300

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056248647 332 vyllvtpRVVEEARKHFDCPVLEGMELENQGGVGTELNHWEKRLLENEAMTGSHTQNrVLSRITLALMEDTGWYKANYSM 411
Cdd:PTZ00257  301 -------TAVAKAREQYGCPTLEYLEVEDQGGSGSAGSHLKGRNAKDELMAPASAAG-YYTALTMAVFEDLGFYKADFSM 372

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056248647 412 AEKLDWGRGMGCDFVRKSCKfwIDQQRQKRQMlspYCDTLRSnplQLTCRQDQRAVAVCNLQKFPKPLPQEYQYFDElsg 491
Cdd:PTZ00257  373 AEVMPWGRNASCDFLTNKCM--EDNITQWPEM---FCNTTER---RYRCPTDRLKLGTCGIRTYSTPMPTYFQYFTN--- 441

                         410       420
                  ....*....|....*....|....*.
gi 2056248647 492 ipaedlPYYGGSVEIADYCPFSQEFS 517
Cdd:PTZ00257  442 ------AFLGGFSAFLDYCPFIVGYS 461
 
Name Accession Description Interval E-value
Peptidase_M8 pfam01457
Leishmanolysin;
99-631 8.70e-61

Leishmanolysin;


Pssm-ID: 366652 [Multi-domain]  Cd Length: 529  Bit Score: 212.40  E-value: 8.70e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056248647  99 LLPEKKNLVKNKLFPQAISYLEKTFQVRRPAGTILLSRQcatnqylrkendphrycTGECaahtkCGPVIVPEEHLqqcr 178
Cdd:pfam01457 105 LTEEKRYILVNYILPQALQLHTERLKVRQVQGTWKVTGM-----------------DGDV-----CGSFKVPPAHV---- 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056248647 179 vyrggkwphgAVGVpdqegiSDADFVLYVGALATErcshENIISYAAYCQQEANmDRPIAGYANLCPNMISTQPQEFvgM 258
Cdd:pfam01457 159 ----------TVGV------SNADFVLYVASVPSE----GGVLAWAFDCQLFPD-GRPAVGVINIPAAYIVSAYDQF--M 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056248647 259 LSTVKHEVIHALGFSAGLFAFYHDKDgnpltsrfadglppfnyslglyqwSDKVVRKverlwdvRDNKivrhtVYLLVTP 338
Cdd:pfam01457 216 VRVVTHELAHALGFSLTFFEMLGIIG------------------------EVKNLRG-------RDYL-----VPVLNSP 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056248647 339 RVVEEARKHFDCPVLEGMELENQGGVGTELNHWEKRLLENEAMTGSHTQNrVLSRITLALMEDTGWYKANYSMAEKLDWG 418
Cdd:pfam01457 260 TVVAKAREQYGCPTLEGLELEDQGGPGTAGSHLKKRNAKDELMAPAVGAG-YYSALTMAVFQDLGFYQADFTKAEVMPWG 338

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056248647 419 RGMGCDFVRKSCkfwidQQRQKRQMLSPYCDtlrSNPLQLTCRQDQRAVAVCNLQKFPKPLPQEYQYFDELSgipaedlp 498
Cdd:pfam01457 339 NNAGCDFLTKKC-----MEDNITQWPEMFCN---STERALRCPTDRLSLGTCSITRHPDPLPTYFQYFTDPS-------- 402

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056248647 499 yYGGSVEIADYCPFSQEFSWHLSGEYQRSSDCRILEnqpeifknygAEKYGPHSVCLiqKSAFVmEKCERKLSYPDWGSg 578
Cdd:pfam01457 403 -LGGGSMFMDYCPYIVGYSNGACNQDPSTASPSLME----------FNVFSDASRCL--DGVFR-PKHSTGITYPYNGL- 467

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2056248647 579 CYQVSCSPQGLKVWVQ---DTSYLCSRAGQVLPVSIQMNGWIHDGNLLCPSCWDFC 631
Cdd:pfam01457 468 CANVRCDRAHHTYSVQvygSSGYVACTPGESVELPTTSAAFVEGGYITCPPYVEVC 523
PTZ00257 PTZ00257
Glycoprotein GP63 (leishmanolysin); Provisional
 99-517 2.30e-38

Glycoprotein GP63 (leishmanolysin); Provisional


Pssm-ID: 240333  Cd Length: 622  Bit Score: 151.01  E-value: 2.30e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056248647  99 LLPEKKNLVKNKLFPQAISYLEKTFQVRRPAGTILLSRQcatnqylrkendphrycTGECaahtkCGPVIVPEEHLQQcr 178
Cdd:PTZ00257  146 LTEEKRDILVSYLIPQALQLHVERLRVRQVQGSWRVTGM-----------------TGPI-----CGDFKVPKAHVTV-- 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056248647 179 vyrggkwphgavgvpdqeGISDADFVLYVGALATErcshENIISYAAYCQQEANmDRPIAGYANL-CPNMISTQPQefvG 257
Cdd:PTZ00257  202 ------------------GVSNADFVLYVASVPSE----PGVLAWATTCQVFSD-DHPAVGVMNIpAANIVSRYDQ---G 255

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056248647 258 MLSTVKHEVIHALGFS------AGLFAFYHDKDGNPLTSrfadglPPFNYSlglyqwsdkvvrkverlwdvrdnkivrht 331
Cdd:PTZ00257  256 TTRTVTHEVAHALGFSsvffenAGIVKSVTNLRGKPFAA------PVINSS----------------------------- 300

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056248647 332 vyllvtpRVVEEARKHFDCPVLEGMELENQGGVGTELNHWEKRLLENEAMTGSHTQNrVLSRITLALMEDTGWYKANYSM 411
Cdd:PTZ00257  301 -------TAVAKAREQYGCPTLEYLEVEDQGGSGSAGSHLKGRNAKDELMAPASAAG-YYTALTMAVFEDLGFYKADFSM 372

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056248647 412 AEKLDWGRGMGCDFVRKSCKfwIDQQRQKRQMlspYCDTLRSnplQLTCRQDQRAVAVCNLQKFPKPLPQEYQYFDElsg 491
Cdd:PTZ00257  373 AEVMPWGRNASCDFLTNKCM--EDNITQWPEM---FCNTTER---RYRCPTDRLKLGTCGIRTYSTPMPTYFQYFTN--- 441

                         410       420
                  ....*....|....*....|....*.
gi 2056248647 492 ipaedlPYYGGSVEIADYCPFSQEFS 517
Cdd:PTZ00257  442 ------AFLGGFSAFLDYCPFIVGYS 461
PTZ00337 PTZ00337
surface protease GP63; Provisional
 165-641 2.87e-34

surface protease GP63; Provisional


Pssm-ID: 185563  Cd Length: 567  Bit Score: 138.11  E-value: 2.87e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056248647 165 GPVIVPEEHLQQCRVYrggKWPHGAVGVpdqeGISDADFVLYVGALATERCSheniiSYAAYCqqeANMD--RPIAGYAN 242
Cdd:PTZ00337  153 RPVLIPRTGLGMCDNF---TIPHKHHTV----GVAGADMILYANIFPTSGPA-----AWAIPC---FLLDdgRPFAAAVN 217

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056248647 243 LCPNMISTQpqefVGMLSTVKHEVIHALGFSAGLFAFYHdkdgnpltsrfadglppfnyslglyqwsdkvvrKVERLWDV 322
Cdd:PTZ00337  218 FDPRQIAVT----NGDVRVAAHELGHALGFVRDQFLMLH---------------------------------MISEVPNV 260

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056248647 323 RDnkivRHTVYLLVTPRVVEEARKHFDCPVLEGMELENQGGVGTELNHWEKRLLENEAMTgSHTQNRVLSRITLALMEDT 402
Cdd:PTZ00337  261 RG----MSKVSVISTPKTKAMARQYHNCPTLEGIELEDEGGPGTALSHWKKRNMRDEMMT-SDVGVGLYSALTLAAFEDM 335

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056248647 403 GWYKANYSMAEKLDWGRGMGCDFVRKSCkfWIDQQRQKRQMlspYCDTLRSNPlQLTCRQDQRAVAVCNLQKFPKPLPQE 482
Cdd:PTZ00337  336 GVYLANYSAAEMLWWGNNSGCGLLEKKC--LTDGISEYPDL---FCNQFDDDE-KFFCTYDRLSLGRCDLKRHEEALPEE 409

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056248647 483 YQYFDElsgipaedlPYYGGSVEIADYCPFSQEFSwhlsgeyqrSSDCRilENQPEIFKnygAEKYGPHSVCLIQKsafv 562
Cdd:PTZ00337  410 YRYFAD---------PRVGGDDLYMSRCPYVKAYS---------NGGCT--NGDPSVMP---GSVVGPNSRCVKGQ---- 462

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056248647 563 mekcerKLSYPD--WGSGCYQVSCSPQGLKVWV--QDTSYLCSRAGQVLPVSiqmNGWihDGNLLCPSCWDFCELCP--- 635
Cdd:PTZ00337  463 ------DLQFDDeyIGDVCVDTRCGDGTLSVRFldDDAWHECQEGETVTPPS---GPW--RGSIVCPQYADVCTAFPnis 531

                         490
                  ....*....|
gi 2056248647 636 ----PETDPP 641
Cdd:PTZ00337  532 shpiPVVDPP 541
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH