BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211904190  15 FSAALRSLVNNPRYSDVCFVVGQERQEVFAHRCLLACRCNFFQRLLGTEPG-PGVPSPVVLSTVPTEAFLAVLEFLYTNS 93
Cdd:cd18294    1 FAADMKSLINNPEFSDVKFLVGPERQEIFAHKCILAARCEVFRAMFLTGPQkESTQSPLVLSDIEPEVFRAVLEFIYTNC 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 211904190  94 VKLYRHSVLEVLTAAVEYGLEELRELCLQF 123
Cdd:cd18294   81 VTLSNHTVIEVLAAAVEYGLDELRKLCERF 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211904190  15 FSAALRSLVNNPRYSDVCFVVGQERQEVFAHRCLLACRCNFFQRLLGTEPG-PGVPSPVVLSTVPTEAFLAVLEFLYTNS 93
Cdd:cd18294    1 FAADMKSLINNPEFSDVKFLVGPERQEIFAHKCILAARCEVFRAMFLTGPQkESTQSPLVLSDIEPEVFRAVLEFIYTNC 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 211904190  94 VKLYRHSVLEVLTAAVEYGLEELRELCLQF 123
Cdd:cd18294   81 VTLSNHTVIEVLAAAVEYGLDELRKLCERF 110

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211904190    30 DVCFVVGQerQEVFAHRCLLACRCNFFQRLLGTEPGPGVPSPVVLSTVPTEAFLAVLEFLYTNSVKLYRHSVLEVLTAAV 109
Cdd:smart00225   1 DVTLVVGG--KKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELAD 78

                           90
                   ....*....|....
gi 211904190   110 EYGLEELRELCLQF 123
Cdd:smart00225  79 YLQIPGLVELCEEF 92

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211904190   137 LQVAVTFGLGQLQERCVAFIEAHSQEALRTRGFLELSAAALLPLLRSDKLCVD-EAELVRAARSWARvgAAVLERpvAEV 215
Cdd:smart00875   5 RRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSsEEEVFEAVLRWVK--HDPEKR--REH 80

                           90
                   ....*....|....*...
gi 211904190   216 AAPVVKELRLALLAPAEL 233
Cdd:smart00875  81 LPELLEHVRLPLLSPDYL 98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211904190  15 FSAALRSLVNNPRYSDVCFVVGQERQEVFAHRCLLACRCNFFQRLLGTEPG-PGVPSPVVLSTVPTEAFLAVLEFLYTNS 93
Cdd:cd18294    1 FAADMKSLINNPEFSDVKFLVGPERQEIFAHKCILAARCEVFRAMFLTGPQkESTQSPLVLSDIEPEVFRAVLEFIYTNC 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 211904190  94 VKLYRHSVLEVLTAAVEYGLEELRELCLQF 123
Cdd:cd18294   81 VTLSNHTVIEVLAAAVEYGLDELRKLCERF 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211904190  28 YSDVCFVVGqeRQEVFAHRCLLACRCNFFQRLLGTEPGPGVPSPVVLSTVPTEAFLAVLEFLYTNSVKLYRHSVLEVLTA 107
Cdd:cd18186    1 LCDVTLVVG--GREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAA 78

                 ....
gi 211904190 108 AVEY 111
Cdd:cd18186   79 ADKL 82

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211904190  20 RSLVNNPRYSDVCFVVgqERQEVFAHRCLLACRCNFFQRLLG---TEPGPGVpspVVLSTVPTEAFLAVLEFLYTNSVK- 95
Cdd:cd18300    1 KLFLNKGLFSDVTFIV--EDGTIPAHKALLVARCDVMAAMFGgnfRESSAKE---VELPGVSKETFLALLEYLYTDQAPi 75

                         90       100
                 ....*....|....*....|....*...
gi 211904190  96 LYRHSVLEVLTAAVEYGLEELRELCLQF 123
Cdd:cd18300   76 LEDGDCVGLIVLANRLCLPRLVALCEQY 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211904190  18 ALRSLVNNPRYSDVCFVVgqERQEVFAHRCLLACRCNFFQRLLGTEPGPGVPSPVVLSTVPTEAFLAVLEFLYTNSVKLY 97
Cdd:cd18298    2 SLRKAFNDPRTSDLKFRV--DGKYIYVHKAILKIRCEYFRSMFQSHWNEDDKNVIEIDQYSYPVYYAFLRYLYTDQVDLP 79

                         90       100
                 ....*....|....*....|....*.
gi 211904190  98 RHSVLEVLTAAVEYGLEELRELCLQF 123
Cdd:cd18298   80 PEDAIGLLDLANSYCEERLKKLCEDI 105

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211904190  19 LRSLVNNPRYSDVCFVVgQERQEVFAHRCLLACRCNFFQRLLGTEpgpgvpsPVVL--STVPTEAFLAVLEFLYTNSVKl 96
Cdd:cd18299    3 LRNLLHSPSCADVVFIL-QGGVRIFAHRIVLAAASSVFADLFLMM-------TVVTldSDITPEAFRRVLEFLYTGVLD- 73

                         90       100
                 ....*....|....*....|....*
gi 211904190  97 YRHSVL-EVLTAAVEYGLEELRELC 120
Cdd:cd18299   74 ENEDDLkELKDAAELLELFDLVMMC 98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211904190  22 LVNNPRYSDVCFVVgqERQEVFAHRCLLACRCNFFQRLLGTEPGPGVPSPVVLSTVPTEAFLAVLEFLYTNSV---KLYR 98
Cdd:cd18297    6 YVNNPEMSDVTFLV--EGRPFYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPDIRYDIFQLMMQYLYTGGVeslDVAQ 83

                         90       100
                 ....*....|....*....|..
gi 211904190  99 HSVLEVLTAAVEYGLEELRELC 120
Cdd:cd18297   84 DDALELLRAASFFQLDGLKRHC 105

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211904190  21 SLVNNPR----YSDVCFVVGQERqeVFAHRCLLACRCNFFQRLLG-----TEPGPGVPSPVVLSTVPTEAFLAVLEFLYT 91
Cdd:cd18296    6 ELPFPPEqelsFPDVCFQVEGHR--FPCHKAFFCGRSDYFKALLRdhfaeSEENNGSIPVVTLHDVSPEVFAIVLYYIYT 83

                         90       100
                 ....*....|....*....|....*....
gi 211904190  92 NSVKLYRHSVLEVLTAAVEYGLEELRELC 120
Cdd:cd18296   84 DDTDLPPENAYDVLYVADMYLLPGLKRLC 112

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211904190  16 SAALRSLVNNPR--YSDVCFVVGQERQeVFAHRCLLACRCNFFQRLL--------GTEPGPGVPSPVVLSTVPTEAFLAV 85
Cdd:cd18310    4 SSDLENLLDSPDlfYSDAEIIVEGGRP-VPVHRCILAARSPFFRDIFasakaegaNTKPKLELRELIPGGIVGYDAFMLV 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 211904190  86 LEFLYTNSVKLYRHSV--------------------LEVLTAAVEYGLEEL 116
Cdd:cd18310   83 LSYLYSGRLRLVPKEGsacvdsdcwhvacrpavdfaLEVLYAASVFQIPEL 133

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211904190  22 LVNNPRYSDVCFVVGQE--RQEVFAHRCLLACRCNFFQRLLGtepGPGVP--SPVVLSTVPTEAFLAVLEFLYTNSVKLY 97
Cdd:cd18281   16 LFNNETLSDVHFIVGKGdnEQRIPAHKFVLSIGSAVFDAMFN---GGMATtsAEIELPDVEPAAFLALLRFLYSDEVQIG 92

                         90       100
                 ....*....|....*....|....*.
gi 211904190  98 RHSVLEVLTAAVEYGLEELRELCLQF 123
Cdd:cd18281   93 PETVMTTLYTAKKYAVPALESACVEF 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211904190  17 AALRSLVNNPRYSDVCFVVGQerQEVFAHRCLLACRCNFFQRLLGTEPGPGVPSPVVLSTVPTEAFLAVLEFLYTNSVKL 96
Cdd:cd18306    7 AKLNALRKNRQFCDVILQVGG--HEIPAHRAVLACASPYLFELFSSDSDGESILTVKLDGLDPDAVEVLVNYAYTSRLEV 84

                         90       100
                 ....*....|....*....|....*..
gi 211904190  97 YRHSVLEVLTAAVEYGLEELRELCLQF 123
Cdd:cd18306   85 PADLVKSVYSAAKKLKMDRVKKACGDF 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211904190  19 LRSLVNNPRYSDVCFVVGQerQEVFAHRCLLACRCNFFQRLLGTEPGPGVPSPVVLSTVPTEAFLAVLEFLYTNSVKLYR 98
Cdd:cd18279    9 LGNLWENSRFTDCCLCVGG--QEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKAPNLD 86

                         90       100
                 ....*....|....*....|..
gi 211904190  99 HSVLEVLTAAVEYGLEELRELC 120
Cdd:cd18279   87 KMADDLLAAADKYALERLKVMC 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211904190  19 LRSLVNNPRYSDVCFVVGQerQEVFAHRCLLACRCNFFQRLLGTEPGPGVPSPVVLSTVPTE---AFLAVLEFLYTNSVK 95
Cdd:cd18292    8 IAQLYNNEELSDIVLRVGG--KVFHAHRLILAKSSDVFRVMLSNDWWSESKQSEIELVEDPEcaaVFEKFLRYLYTGQIS 85

                         90       100
                 ....*....|....*....|....*...
gi 211904190  96 LYRHSVLEVLTAAVEYGLEELRELCLQF 123
Cdd:cd18292   86 VNLETALPLLMLADKYNVTDLKQLCVDF 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211904190  21 SLVNNPRYSDVCFVVGQ--ERQEVFAHRCLLACRCNFFQRLLGTEPGPGvPSPVVLSTVPTEAFLAVLEFLYTNSVKLYR 98
Cdd:cd18349    1 LMFNNELMADVHFIVGPpgASQRVPAHKYVLAVGSSVFYAMFYGDLAEV-KSEIHIPDVEPAAFLILLKYMYSDEIDLEA 79

                         90       100
                 ....*....|....*....|....*
gi 211904190  99 HSVLEVLTAAVEYGLEELRELCLQF 123
Cdd:cd18349   80 DTVLATLYAAKKYIVPALAKACVNF 104

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211904190  23 VNNPRYSDVCFVVgqERQEVFAHR-CLLACRCNF---FQRLLGTEPGPGVPSPVVLSTVpteaFLAVLEFLYTNSVKLYR 98
Cdd:cd18352    8 VNNATLSDVTFLV--EGRRFYAHRiALLASSDAFramFDGGYREKEARDIEIPNIRWEV----FELMMRFIYTGSVDITN 81

                         90       100
                 ....*....|....*....|..
gi 211904190  99 HSVLEVLTAAVEYGLEELRELC 120
Cdd:cd18352   82 DIAKDLLRAADQYLLEGLKRLC 103

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 211904190  30 DVCFVVGQERqeVFAHRCLLACRCNFFQRLLG----TEPGPGVPSPVVLSTVPTEAFLAVLEFLYTNS 93
Cdd:cd18301   20 DVVFQVGGKT--FPAHKFILASRSDYFRKLFLssllTSEDAVGCDVVHIEKVPPEIFEQLLQFIYTDT 85

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211904190  19 LRSLVNNPRYSDVCFVVgqERQEVFAHRCLLACRCNFFQRLLGTEPGPGVPSPVVLSTVPTEAFLAVLEFLYTNSVKL-Y 97
Cdd:cd18286    8 LLQLFLNGEDSDITIKV--DGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAAVSFVLLFIYGGVLDLpD 85

                         90       100
                 ....*....|....*....|....*
gi 211904190  98 RHSVLEVLTAAVEYGLEELRELCLQ 122
Cdd:cd18286   86 DVNLGELLSLADMYGLDGLKDVVAY 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211904190  22 LVNNPRYSDVCFVVgqERQEVFAHRCLLACRCNFFQRLLGTEPgPGVPSPVVLSTVPTEAFLAVLEFLY---TNSVKLYR 98
Cdd:cd18351   18 FLNNKEMSDVTFLV--EGRPFYAHKVLLFTASPRFKALLSNKP-SAENTCIEISYVKYHIFQLVMQYLYcggTESLLIKN 94

                         90       100
                 ....*....|....*....|..
gi 211904190  99 HSVLEVLTAAVEYGLEELRELC 120
Cdd:cd18351   95 NEIMELLSAAKFFQLEALQRHC 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211904190  22 LVNNPRYSDVCFVVGQ--ERQEVFAHRCLLACRCNFFQRLLGTEPGPgVPSPVVLSTVPTEAFLAVLEFLYTNSVKLYRH 99
Cdd:cd18347   16 LFNNEVLSDVHFLVGKglGSQRIPAHRFVLAVGSAVFDAMFNGGMAT-TSTEIELPDVEPAAFLALLKFLYSDEVQIGPE 94

                         90       100
                 ....*....|....*....|....
gi 211904190 100 SVLEVLTAAVEYGLEELRELCLQF 123
Cdd:cd18347   95 TVMTTLYTAKKYAVPALEAHCVEF 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211904190  30 DVCFVVgqERQEVFAHRCLLA-CRCNFFQRLLGTEPGPGVPSpvVLSTVPTEAFLAVLEFLYTNSVKLYRHSVLEVLTAA 108
Cdd:cd18955    3 DVTIVV--EDQRFRAHRAVLAaCSDYFLSRVVGQTDGDLVIT--LPEEVTVKGFEPLLQFAYTAKLLLSKENVLEVCRCA 78

                         90
                 ....*....|....*
gi 211904190 109 VEYGLEELRELCLQF 123
Cdd:cd18955   79 EFLGVHNIEKACFDF 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211904190  24 NNPRYSDVCFVVGQErqEVFAHRCLLACRCNFFQRLLGTEPGP-GVPSPVVLSTVPTEAFLAVLEFLYTNSVKLYRHSVL 102
Cdd:cd18207   23 SGGRFCDVLLRVGEE--SFPAHRAVLAACSEYFESVFSAQEGDgGTPRELEMHTISSKVFGDILDFAYTSRIVVRLESFP 100

                         90
                 ....*....|....*...
gi 211904190 103 EVLTAAVEYGLEELRELC 120
Cdd:cd18207  101 ELMTAAKFLLMRSVIDIC 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211904190  32 CFVVGQ-ERQEVFAHRCLLACRCNFFQRLLGTEPGP-GVPSPVVLSTVPTEAFLAVLEFLYTNSVKLYRHSVLEVLTAAV 109
Cdd:cd18293   16 CDVLLQaEGESVPAHCCVLSACSPYLTERLSSEPPPaGQKVVLELQGLKAHTLLKLVDFLYTSELEVSSEEAQDVLAAAR 95

                         90
                 ....*....|...
gi 211904190 110 EYGLEELRELCLQ 122
Cdd:cd18293   96 RLQISELESLCLE 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211904190  30 DVCFVVgqERQEVFAHRCLLACRCNFFQRLLGTEPGPGVPSPVVLSTVPTEAFLAVLEFLYTNSVKLYRHSVLEVLTAAV 109
Cdd:cd18328   27 DVVLIV--QDQEYRTHRSVLAACSKYFKKLFTAGTLADQPYVYEIDFVTPEALSAILEFAYTSTLTITTSNVKHILNAAQ 104

                         90
                 ....*....|...
gi 211904190 110 EYGLEELRELCLQ 122
Cdd:cd18328  105 MLEIQCIINVCLE 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211904190  19 LRSLVNNPRYSDVCFVVGQErqEVFAHRCLLACRCNFFQRLLGTEPGPGVPSPVVLSTVPTEAFLAVLEFLYTNSV---- 94
Cdd:cd18280    5 FGALLESEEGADVTFNVDGE--KFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIEDVEPPVFKALLHFIYKDELpddv 82

                         90       100       110
                 ....*....|....*....|....*....|....
gi 211904190  95 --------KLYRHSVLEVLTAAVEYGLEELRELC 120
Cdd:cd18280   83 epagsdssSLDTTMAQHLLAAADRYALERLRLLC 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 211904190  31 VCFVVGQERQEVfaHRCLLACRCNFFQRLLGTEPGPGVPSPVVLSTVPTEAFLAVLEFLYTNSVKLYRHSVLEVLTAA 108
Cdd:cd01165    1 VVLVVEGEKFHV--NKELLAQSSEYFRALFRGGFRESGQAEINLRDISPEDFRALLEFLYGGKRDLDASNLLELLEAA 76

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211904190  15 FSAALRSLVNNPRYSDV---CFVVGQERqeVF-AHRCLLACRCNFFQRLL-GTEPGPGVPSPVVLSTVPTEAFLAVLEFL 89
Cdd:cd18330    1 YYTKLLGELNEQRKRDFfcdCSIIVEGR--IFkAHRNILFANSGYFRALLiHYIQDSGRHSTASLDIVTSEAFSIILDFL 78

                         90       100       110
                 ....*....|....*....|....*....|.
gi 211904190  90 YTNSVKLYRHSVLEVLTAAVEYGLEELRELC 120
Cdd:cd18330   79 YSGKLDLCSENVIEVMSAASYLQMTDVVNFC 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.