Zinc-finger double domain;

                          10        20
                  ....*....|....*....|...
gi 212286156  349 LKRHERTHSGEKPYTCVQCGKSF 371
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212286156   14 LRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFH-LFYRDRPAGSRDTVRLNGdiVTAPAFGRLLDFMYEGRLdLRS 92
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKaLFSGQESESSVSEITLDD--VSPEDFEALLEFMYTGKL-ISE 77

                          90       100
                  ....*....|....*....|..
gi 212286156   93 LPVEDVLAAASYLHMYDIVKVC 114
Cdd:pfam00651  78 ENVDDLLAAADKLQIPSLVDKC 99

kelch-like protein; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212286156  19 ELGFLCDCTVLV--GDARFPAHRAVLAACSVYFHLFYRDRpaGSRDTVRLNGDIvtaPAFGRLLDFMYEGRLDLRSLPVE 96
Cdd:PHA03098   5 ELQKFCDESIIIvnGGGIIKVHKIILSSSSEYFKKMFKNN--FKENEINLNIDY---DSFNEVIKYIYTGKINITSNNVK 79

                         90
                 ....*....|....*...
gi 212286156  97 DVLAAASYLHMYDIVKVC 114
Cdd:PHA03098  80 DILSIANYLIIDFLINLC 97

FOG: Zn-finger [General function prediction only];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212286156 292 PLCICPLCSKLFPSSHVLQLHLSAHFRErdSTRARLSPdgvaPTCPLCGKTFSCTYTLKRHERT--HSGEKPYTCVQ--- 366
Cdd:COG5048  254 SSSASESPRSSLPTASSQSSSPNESDSS--SEKGFSLP----IKSKQCNISFSRSSPLTRHLRSvnHSGESLKPFSCpys 327

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 212286156 367 -CGKSFQYSHNLSRHTVVHTREKPHACRWCERRFTQSGDL 405
Cdd:COG5048  328 lCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL 367

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212286156   1 MEFPEHGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFHLFYRDRPaGSRDTVRLNGDIVTAPAFGRLL 80
Cdd:cd18194    1 MEFPEHSRQLLQCLREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFHLFYRDRL-DKRDLVRLNSDIVTAPAFGLLL 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 212286156  81 DFMYEGRLDLRSLPVEDVLAAASYLHMYDIVKVCKGRLQEKDRSLDPGN 129
Cdd:cd18194   80 DFMYEGRLALRDLPVEDVLAAASYLHMYDIVKVCKGRLQEKALAEADST 128

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212286156   1 MEFPEHGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFHLFYRDRpAGSRDTVRLNGDIVTAPAFGRLL 80
Cdd:cd18324    1 MEFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQ-LDKRDIVHLNSDIVTAPAFALLL 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 212286156  81 DFMYEGRLDLRSLPVEDVLAAASYLHMYDIVKVCKGRLQEK 121
Cdd:cd18324   80 EFMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKEK 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212286156   2 EFPEHGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFHLFYRDRpagsRDTVRLngDIVTAPAFGRLLD 81
Cdd:cd18206    1 DFPQHSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLFVDQ----KDVVHL--DISNAAGLGQVLE 74

                         90       100       110
                 ....*....|....*....|....*....|...
gi 212286156  82 FMYEGRLDLRSLPVEDVLAAASYLHMYDIVKVC 114
Cdd:cd18206   75 FMYTAKLSLSPENVDDVLAVATFLQMQDIVTAC 107

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212286156   14 LRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFH-LFYRDRPAGSRDTVRLNGdiVTAPAFGRLLDFMYEGRLdLRS 92
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKaLFSGQESESSVSEITLDD--VSPEDFEALLEFMYTGKL-ISE 77

                          90       100
                  ....*....|....*....|..
gi 212286156   93 LPVEDVLAAASYLHMYDIVKVC 114
Cdd:pfam00651  78 ENVDDLLAAADKLQIPSLVDKC 99

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212286156   9 RLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFH--LFYRDRPAGSRDTVRLngDIVTAPAFGRLLDFMYEG 86
Cdd:cd18330    4 KLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRalLIHYIQDSGRHSTASL--DIVTSEAFSIILDFLYSG 81

                         90       100       110
                 ....*....|....*....|....*....|
gi 212286156  87 RLDLRSLPVEDVLAAASYLHMYDIVKVCKG 116
Cdd:cd18330   82 KLDLCSENVIEVMSAASYLQMTDVVNFCKG 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212286156  23 LCDCTVLVGDARFPAHRAVLAACSVYFH-LFYRDRPAGSRDTVRLNGdiVTAPAFGRLLDFMYEGRLDLRSLPVEDVLAA 101
Cdd:cd18186    1 LCDVTLVVGGREFPAHRAVLAARSPYFRaMFSSGMKESSSSEIELDD--VSPEAFEALLDYIYTGELELSEENVEELLAA 78

                 ....
gi 212286156 102 ASYL 105
Cdd:cd18186   79 ADKL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212286156   3 FPEHGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFHLFYRDRPAGSRDTVRLNGDIVTAPAFGRLLDF 82
Cdd:cd18329    1 ISSHQSRLLQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQNAKETGQPTVATFDVFSPDTFTIILDF 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 212286156  83 MYEGRLDLRSLPVEDVLAAASYLHMYDIVKVCK 115
Cdd:cd18329   81 VYSGKLSLTSQNVIEVMSAASYLQMTDVISVCK 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212286156   4 PEHGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFHLFYRDRPAGSRDTVRLNGDIVTAPAFGRLLDFM 83
Cdd:cd18230    2 TSHYRHLLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVTHLDIVTAQGFKAIIDFM 81

                         90       100       110
                 ....*....|....*....|....*....|...
gi 212286156  84 YEGRLDLRSLPVEDVLAAASYLHMYDIVKVCKG 116
Cdd:cd18230   82 YSAHLALTSKNVIEVMSAASYLQMTDIVQACHN 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212286156   3 FPEHGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFH-LFYRDrpagsrDTVRLNGDIVTAPAFGRLLD 81
Cdd:cd18334    1 LPNHAKQLLLQLNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFKsLVLHD------NLINLDTDMVNPTVFRQILD 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 212286156  82 FMYEGRLDLRSLPVED----VLAAASYLHMYDIVKVCKGRLQEKDR 123
Cdd:cd18334   75 FIYTGKLLTSDQPGEQnfnaLLTAASYLQLHDLAALCRKKLKRNGK 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212286156   5 EHGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFHLFYRDRPAGSRDTVR------LNGDIVTAPAFGR 78
Cdd:cd18228    1 SHSQELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVGQASPRLVLVSpagkcvLDLHHVTVTGFAP 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 212286156  79 LLDFMYEGRLDLRSLPVEDVLAAASYLHMYDIVKVC 114
Cdd:cd18228   81 LLEYAYTSTLSINTENIIDVLAAASYMQMFNVANTC 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212286156   4 PEHGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFH-LFYRDrpagsrDTVRLNGDIVTAPAFGRLLDF 82
Cdd:cd18333    2 PSHSRQLLLQLNTQRTKGFLCDVIIVVQNALFRAHKNILAASSVYLKsLVVHD------NLINLDHEMVSPGIFRLILDY 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 212286156  83 MYEGRLDLRSLPVED----VLAAASYLHMYDIVKVCKGRLQ 119
Cdd:cd18333   76 IYTGRLSEGDPGSEQnlgaVLAAASYLQIPDLVALCKKKLK 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212286156   6 HGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFH-LFYRDRPAGSRDTVRLNGdiVTAPAFGRLLDFMY 84
Cdd:cd18261   11 HKDAVLAALNQQRNDGILCDITLVAEEQKFHAHKAVLAACSDYFRaMFSLCMVESEADEVNLHG--VTSLGLKQALDFAY 88

                         90       100       110
                 ....*....|....*....|....*....|
gi 212286156  85 EGRLDLRSLPVEDVLAAASYLHMYDIVKVC 114
Cdd:cd18261   89 TGQILLEPGVIQDVLAAGSHLQLLELLSLC 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212286156   6 HGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFH-LFYRDRPAGSRDTVRLNGdiVTAPAFGRLLDFMY 84
Cdd:cd18256    3 HASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAaLFAGGMSESSKDVVQIHG--VEPDIFHILLDFIY 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 212286156  85 EGRLDLRSLPVEDVLAAASYLHMYDIVKVCKGRLQekdRSLDPGN 129
Cdd:cd18256   81 TGVVEVTVSNVQELLVAADMLQLTEVVEICCEFLK---GQLHPSN 122

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212286156   6 HGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFHLFYRDRPAGSRDTVRLNGdiVTAPAFGRLLDFMYE 85
Cdd:cd18212    6 HKDTVLTNFEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFADEGEVGQSIYMLEG--MVAETFGALLEFIYT 83

                         90       100
                 ....*....|....*....|....*..
gi 212286156  86 GRLDLRSLPVEDVLAAASYLHMYDIVK 112
Cdd:cd18212   84 GCLQVGEKSLEQILATAQFLKVNDLVK 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212286156   5 EHGGRLLGRLRQQRELG-FLCDCTVLVGDARFPAHRAVLAACSVYFHLFYRDRPAGSRDTVRLNGDIVTAPAFGRLLDFM 83
Cdd:cd18207    8 QHSADMLHNLNQQRKSGgRFCDVLLRVGEESFPAHRAVLAACSEYFESVFSAQEGDGGTPRELEMHTISSKVFGDILDFA 87

                         90       100       110
                 ....*....|....*....|....*....|..
gi 212286156  84 YEGRLDLRSLPVEDVLAAASYLHMYDIVKVCK 115
Cdd:cd18207   88 YTSRIVVRLESFPELMTAAKFLLMRSVIDICQ 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212286156   6 HGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFHLFYRDRPAGSRDTVRLNGDIvTAPAFGRLLDFMYE 85
Cdd:cd18332    2 HSSDVLLNLNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSGRVGEGVSVLTLPSGL-EARGFQLLLDFMYT 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 212286156  86 GRLDLRSLPVEDVLAAASYLHMYDIVKVCKGRLQ 119
Cdd:cd18332   81 SRLPLTPRTVPAVLAAATYLQMEHVVETCRRFIQ 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212286156   1 MEFPEHGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFHLFYRdrpagSRDTVRLNGDIVTAPAFGRLL 80
Cdd:cd18225    1 MELPNYSRQLLQQLHTLRKEQQFCDCTIFIGTFHFRAHKLVLAASSLLFKSLLD-----STDTISIDASVVSPEEFALLL 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 212286156  81 DFMYEGRLDLRSLPVEDVLAAASYLHMYDIVKVCKGRLQE 120
Cdd:cd18225   76 EMVYTGKLPPGKHNFTKIISVADSLQMFDVAVSCKNLLTS 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212286156   6 HGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFHLFYRDrpaGSRDTVRLNGDIvtAPAFGRLLDFMYE 85
Cdd:cd18232    1 HSVKVLQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLYGD---GTSGSVVLPESF--AEVFGLLLDFFYT 75

                         90       100       110
                 ....*....|....*....|....*....|
gi 212286156  86 GRLDLRSLPVEDVLAAASYLHMYDIVKVCK 115
Cdd:cd18232   76 GELALTRENRDRVLLAAKELRVPEAVELCQ 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212286156  23 LCDCTVLVGDARFPAHRAVLAACSVYFH-LFYRDRPAGSRDTVRLNGdiVTAPAFGRLLDFMYEGRLDLRSLPVEDVLAA 101
Cdd:cd18234    1 LCDVILIAGDRRIPAHRLVLSAVSDYFAaMFTNDVREATEEEIKLKD--VDPDALWTLVQYCYTGRLELKEDNVESLLAT 78

                         90       100
                 ....*....|....*....|....*...
gi 212286156 102 ASYLHMYDIVKVCKGRLQekdRSLDPGN 129
Cdd:cd18234   79 ACLLQLSEVVEACCGFLM---KQLHPSN 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212286156   6 HGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFH-LFYRDRPAGSRDTVRLNGdiVTAPAFGRLLDFMY 84
Cdd:cd18244   13 HDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRiMFTADMRERDQDKIHLKG--LTATGFSHVLQFMY 90

                         90       100       110
                 ....*....|....*....|....*....|
gi 212286156  85 EGRLDLRSLPVEDVLAAASYLHMYDIVKVC 114
Cdd:cd18244   91 YGTIELSMLTVHEILQAAMYVQLTEVVKFC 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212286156  10 LLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFH-LFYRDRPAGSRDTVRLNGDIVTAPAFGRLLDFMYEGRL 88
Cdd:cd18245    1 LLRALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRaKLNYNPPKDDGSTYKIELEGISVEVMEEILDYIYTGQI 80

                         90       100
                 ....*....|....*....|....*.
gi 212286156  89 DLRSLPVEDVLAAASYLHMYDIVKVC 114
Cdd:cd18245   81 KLSEDNIQDIVQAADLLLMTDLKDLC 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212286156   6 HGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFHlfyrDRPAGSRD---TVRLNGDiVTAPAFGRLLDF 82
Cdd:cd18277   10 HSTNVLLSLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFH----SRIVGQADaelNITLPEE-VTVKGFEPLIQF 84

                         90       100       110
                 ....*....|....*....|....*....|..
gi 212286156  83 MYEGRLDLRSLPVEDVLAAASYLHMYDIVKVC 114
Cdd:cd18277   85 AYTAKLILSKDNVDEVCKCVEFLSVHNIEESC 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 2 (ZBTB2); ZBTB2 is a POZ domain Kruppel-like zinc finger (POK) family transcription factor acting as a potent repressor of the ARF-HDM2-p53-p21 pathway, which is important in cell cycle regulation. It represses transcription of the ARF, p53, and p21 genes, but activates the HDM2 gene. ZBTB2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212286156   6 HGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFHLFYRDRpagSRDTVRLNGDIVTAPAFGRLLDFMYE 85
Cdd:cd18193    4 HGLILLQQLNAQREFGFLCDCTVAIGDVYFKAHKSVLASFSNYFKMLFVHQ---TSECVRLKPTDIQPDIFSYLLHLMYT 80