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Conserved domains on  [gi|215490100|ref|NP_001135922|]
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protein spinster homolog 1 isoform 2 [Homo sapiens]

Protein Classification

spinster family MFS transporter( domain architecture ID 13023647)

spinster family major facilitator superfamily (MFS) transporter may function as a sphingolipid transporter that plays a central role in endosome and/or lysosome storage

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0006869
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1.49

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 1-406 1.42e-179

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 507.54  E-value: 1.42e-179
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   1 MDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPgeHFWLL 80
Cdd:cd17328   13 MDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAP--NFWQL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100  81 LLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGDWHWALRVTPGLGVVAVLL 160
Cdd:cd17328   91 LLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFRVTGVLGVLLAIL 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100 161 LFLVVREPPRGAVERHsDLPPLNPTSWWADLRALARNPSFVLSSLGFTAVAFVTGSLALWAPAFLLRSRVVlgetppclp 240
Cdd:cd17328  171 LLLFVREPPRGAAEGG-VMAKSTATSFLADLKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGV--------- 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100 241 GDSCSSSDSLIFGLITCLTGVLGVGLGVEISRRLRHSNPRADPLVCATGLLGSAPFLFLSLACARGSIVATYIFIFIGET 320
Cdd:cd17328  241 GDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKTPRADPLVCAVGLLAAAPFLFLALVLALSNLLLAWVLLFLGEF 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100 321 LLSMNWAIVADILLYVVIPTRRSTAEAFQIVLSHLLGDAGSPYLIGLISDRLRRNwPPSFLSEFRALQFSLMLCAFVGAL 400
Cdd:cd17328  321 LLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHLLGDAGSPYLIGLISDLLRQN-KDSPLAEAASLQYALLLCSFVLVL 399


                 ....*.
gi 215490100 401 GGAAFL 406
Cdd:cd17328  400 GGFFFL 405
 
Name Accession Description Interval E-value
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 1-406 1.42e-179

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 507.54  E-value: 1.42e-179
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   1 MDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPgeHFWLL 80
Cdd:cd17328   13 MDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAP--NFWQL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100  81 LLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGDWHWALRVTPGLGVVAVLL 160
Cdd:cd17328   91 LLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFRVTGVLGVLLAIL 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100 161 LFLVVREPPRGAVERHsDLPPLNPTSWWADLRALARNPSFVLSSLGFTAVAFVTGSLALWAPAFLLRSRVVlgetppclp 240
Cdd:cd17328  171 LLLFVREPPRGAAEGG-VMAKSTATSFLADLKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGV--------- 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100 241 GDSCSSSDSLIFGLITCLTGVLGVGLGVEISRRLRHSNPRADPLVCATGLLGSAPFLFLSLACARGSIVATYIFIFIGET 320
Cdd:cd17328  241 GDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKTPRADPLVCAVGLLAAAPFLFLALVLALSNLLLAWVLLFLGEF 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100 321 LLSMNWAIVADILLYVVIPTRRSTAEAFQIVLSHLLGDAGSPYLIGLISDRLRRNwPPSFLSEFRALQFSLMLCAFVGAL 400
Cdd:cd17328  321 LLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHLLGDAGSPYLIGLISDLLRQN-KDSPLAEAASLQYALLLCSFVLVL 399


                 ....*.
gi 215490100 401 GGAAFL 406
Cdd:cd17328  400 GGFFFL 405
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
1-406 9.97e-26

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 107.65  E-value: 9.97e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   1 MDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLL 80
Cdd:COG2271   24 LDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATS--FWQL 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100  81 LLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHWALRVTpglgvvavll 160
Cdd:COG2271  102 LLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFG-WRAAFLIL---------- 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100 161 lflvvrepprGAVerhsdlpplnptswwADLRALARnpsFVLSSLGFTAVAFVTGSLALWAPAFLLRSRVVlgetppclp 240
Cdd:COG2271  171 ----------GLP---------------GLLLALLR---FWLLALAYFLVYFALYGFLTWLPTYLVEVRGL--------- 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100 241 gdscSSSDSLIFGLITCLTGVLGVGLGVEISRRLRhsnpRADPLVCATGLLGSAPFLFLSLACarGSIVATYIFIFIGET 320
Cdd:COG2271  214 ----SLAQAGLLLSLPFLAGIVGSLLGGWLSDRLG----RRRKLVLAIGLLLAALALLLLALL--PSPALAIALLFLAGF 283

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100 321 LLSMNWAIVADILLYVVIPTRRSTAEAFqIVLSHLLGDAGSPYLIGLISDRLrrnwppsflsefrALQFSLMLCAFVGAL 400
Cdd:COG2271  284 GLGGAFGLLWALAAELFPKKARGTASGL-VNTFGFLGGALGPLLVGYLLDAT-------------GYQAAFLLLAALALL 349


                 ....*.
gi 215490100 401 GGAAFL 406
Cdd:COG2271  350 AALLAL 355
MFS_1 pfam07690
Major Facilitator Superfamily;
1-330 1.25e-17

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 83.62  E-value: 1.25e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100    1 MDRFTVAGVLP-DIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWL 79
Cdd:pfam07690  10 LGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASS--LWL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   80 LLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHWALRVTPGLGVVAVL 159
Cdd:pfam07690  88 LLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-WRAAFLILAILSLLAAV 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100  160 LLFLVVREPPRGAVERHSDLPPLNPTSWwadlRALARNPSFVLsSLGFTAVAFVTGSLALWAPAFLLRSRVvlgetppcl 239
Cdd:pfam07690 167 LLLLPRPPPESKRPKPAEEARLSLIVAW----KALLRDPVLWL-LLALLLFGFAFFGLLTYLPLYQEVLGL--------- 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100  240 pgdscSSSDSLIFGLITCLTGVLGVGLGVEISRRLRHSNPRAdpLVCATGLLGSAPFLFLSLACARGSIVATYIFIFIGE 319
Cdd:pfam07690 233 -----SALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLL--LALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGF 305

                         330
                  ....*....|.
gi 215490100  320 TLLSMNWAIVA 330
Cdd:pfam07690 306 GLVFPALNALV 316
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 2-236 6.65e-11

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 63.55  E-value: 6.65e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100    2 DRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPgeHFWLLL 81
Cdd:TIGR00881  10 VRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFST--SLWVMA 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   82 LTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGDWHWALRVTPGLGVVAVLLL 161
Cdd:TIGR00881  88 ALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLIC 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100  162 FLVVREPPRG------------AVERHSDLPPLNPTSWWADLRALARNPSFVLSSLGFTAVAFVTGSLALWAPAFLLRSR 229
Cdd:TIGR00881 168 FLLLRDSPQScglppaeempneEPDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEK 247


                  ....*..
gi 215490100  230 VVLGETP 236
Cdd:TIGR00881 248 GFSKEKA 254
 
Name Accession Description Interval E-value
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 1-406 1.42e-179

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 507.54  E-value: 1.42e-179
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   1 MDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPgeHFWLL 80
Cdd:cd17328   13 MDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAP--NFWQL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100  81 LLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGDWHWALRVTPGLGVVAVLL 160
Cdd:cd17328   91 LLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFRVTGVLGVLLAIL 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100 161 LFLVVREPPRGAVERHsDLPPLNPTSWWADLRALARNPSFVLSSLGFTAVAFVTGSLALWAPAFLLRSRVVlgetppclp 240
Cdd:cd17328  171 LLLFVREPPRGAAEGG-VMAKSTATSFLADLKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGV--------- 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100 241 GDSCSSSDSLIFGLITCLTGVLGVGLGVEISRRLRHSNPRADPLVCATGLLGSAPFLFLSLACARGSIVATYIFIFIGET 320
Cdd:cd17328  241 GDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKTPRADPLVCAVGLLAAAPFLFLALVLALSNLLLAWVLLFLGEF 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100 321 LLSMNWAIVADILLYVVIPTRRSTAEAFQIVLSHLLGDAGSPYLIGLISDRLRRNwPPSFLSEFRALQFSLMLCAFVGAL 400
Cdd:cd17328  321 LLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHLLGDAGSPYLIGLISDLLRQN-KDSPLAEAASLQYALLLCSFVLVL 399


                 ....*.
gi 215490100 401 GGAAFL 406
Cdd:cd17328  400 GGFFFL 405
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 1-406 1.86e-27

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 112.91  E-value: 1.86e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   1 MDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLL 80
Cdd:cd06174   10 LARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPS--FWLL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100  81 LLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAG-DWHWALRVTPGLGVVAVL 159
Cdd:cd06174   88 LLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGfGWRAVFLIAAALALLAAI 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100 160 LLFLVVREPPRGAVERHSdlpPLNPTSWWADLRALARNPSFVLSSLGFTAVAFVTGSLALWAPAFLLRSRVVLGETPpcl 239
Cdd:cd06174  168 LLLLVVPDPPESARAKNE---EASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVA--- 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100 240 pgdscsssdsLIFGLITCLTGVLGVGLGVEISRRLRhsnPRADPLVCATGLLGSAPFLFLSLACARGSIVATYIFIFIGE 319
Cdd:cd06174  242 ----------GLLLSLFGLAGALGSLLLGLLSDRLI---GRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLG 308

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100 320 TLLSMNWAIVADIllyvVIPTRRSTAEAFQIVLSHLLGDAGSPYLIGLISDRLrrnwppsflsefrALQFSLMLCAFVGA 399
Cdd:cd06174  309 GLLPLSFALIAEL----FPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATF-------------GLTGAFLVLAVLLL 371


                 ....*..
gi 215490100 400 LGGAAFL 406
Cdd:cd06174  372 LAAILLL 378
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
1-406 9.97e-26

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 107.65  E-value: 9.97e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   1 MDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLL 80
Cdd:COG2271   24 LDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATS--FWQL 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100  81 LLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHWALRVTpglgvvavll 160
Cdd:COG2271  102 LLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFG-WRAAFLIL---------- 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100 161 lflvvrepprGAVerhsdlpplnptswwADLRALARnpsFVLSSLGFTAVAFVTGSLALWAPAFLLRSRVVlgetppclp 240
Cdd:COG2271  171 ----------GLP---------------GLLLALLR---FWLLALAYFLVYFALYGFLTWLPTYLVEVRGL--------- 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100 241 gdscSSSDSLIFGLITCLTGVLGVGLGVEISRRLRhsnpRADPLVCATGLLGSAPFLFLSLACarGSIVATYIFIFIGET 320
Cdd:COG2271  214 ----SLAQAGLLLSLPFLAGIVGSLLGGWLSDRLG----RRRKLVLAIGLLLAALALLLLALL--PSPALAIALLFLAGF 283

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100 321 LLSMNWAIVADILLYVVIPTRRSTAEAFqIVLSHLLGDAGSPYLIGLISDRLrrnwppsflsefrALQFSLMLCAFVGAL 400
Cdd:COG2271  284 GLGGAFGLLWALAAELFPKKARGTASGL-VNTFGFLGGALGPLLVGYLLDAT-------------GYQAAFLLLAALALL 349


                 ....*.
gi 215490100 401 GGAAFL 406
Cdd:COG2271  350 AALLAL 355
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-332 1.49e-20

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 92.34  E-value: 1.49e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   1 MDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPgeHFWLL 80
Cdd:COG2814   24 LGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAP--SLWLL 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100  81 LLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHWALRVTPGLGVVAVLL 160
Cdd:COG2814  102 LAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG-WRWVFLVNAVLALLALLL 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100 161 LFLVVREPprgaverhsdlPPLNPTSWWADLRALARNPSFVLSSLGFTAVAFVTGSLALWAPAFLLRsrvVLGETPpclp 240
Cdd:COG2814  181 LLRLLPES-----------RPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQE---VLGLSA---- 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100 241 gdscssSDSLIFGLITCLTGVLGVGLGVEISRRLrhsnpRADPLVCATGLLGSAPFLFLSLACARGSIVATYIFIFIGET 320
Cdd:COG2814  243 ------SAAGLLLALFGLGGVLGALLAGRLADRF-----GRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFG 311

                        330
                 ....*....|...
gi 215490100 321 LL-SMNWAIVADI 332
Cdd:COG2814  312 LLfPLLQALVAEL 324
MFS_1 pfam07690
Major Facilitator Superfamily;
1-330 1.25e-17

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 83.62  E-value: 1.25e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100    1 MDRFTVAGVLP-DIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWL 79
Cdd:pfam07690  10 LGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASS--LWL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   80 LLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHWALRVTPGLGVVAVL 159
Cdd:pfam07690  88 LLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-WRAAFLILAILSLLAAV 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100  160 LLFLVVREPPRGAVERHSDLPPLNPTSWwadlRALARNPSFVLsSLGFTAVAFVTGSLALWAPAFLLRSRVvlgetppcl 239
Cdd:pfam07690 167 LLLLPRPPPESKRPKPAEEARLSLIVAW----KALLRDPVLWL-LLALLLFGFAFFGLLTYLPLYQEVLGL--------- 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100  240 pgdscSSSDSLIFGLITCLTGVLGVGLGVEISRRLRHSNPRAdpLVCATGLLGSAPFLFLSLACARGSIVATYIFIFIGE 319
Cdd:pfam07690 233 -----SALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLL--LALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGF 305

                         330
                  ....*....|.
gi 215490100  320 TLLSMNWAIVA 330
Cdd:pfam07690 306 GLVFPALNALV 316
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 9-397 1.25e-15

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 78.00  E-value: 1.25e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   9 VLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPgeHFWLLLLTRGLVG 88
Cdd:cd17325   18 ILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFAT--SYWQLLLARFLQG 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100  89 VGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdwHWALRVTPGLGVVAVLLLFLVVREP 168
Cdd:cd17325   96 LASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG--YRAPFLVCAALALLALVLALLLLPE 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100 169 PRGAVERHSDLPPLNPTSWWadlrALARNPSFVLSSLGFTAVAFVTGSLalwAPAFLLRSRVVLGETPpclpgdscsSSD 248
Cdd:cd17325  174 PRPPPNKRAVSAARLRSGLR----LLLRDRRLLALFLAIFVLAFAFGAL---EPFLPLYAAELGGLSP---------AQI 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100 249 SLIF---GLITCLTGVLGVGLGVEISRRlrhsnpradPLVCATGLLGSAPFLFLSLACARGSIVATYIFIFIGetlLSMN 325
Cdd:cd17325  238 GLLFgaqGLASALSQPPAGKLSDRIGRK---------PLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLG---LGLV 305

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 215490100 326 WAIVADILLYVVIPTRRSTAEA-FQIVLShlLGDAGSPYLIGLISDRLrrnwppSFLSEFRALQFSLMLCAFV 397
Cdd:cd17325  306 FPATLALLADIVPPEGRGTAMGlFNTAFS--LGMVLGPLLGGFLYDAF------GFATPFLAAAALLLLAAVL 370
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 4-146 5.72e-15

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 76.05  E-value: 5.72e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   4 FTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLLLLT 83
Cdd:cd17324   16 YVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPS--FALLLLA 93

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 215490100  84 RGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHWA 146
Cdd:cd17324   94 RALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLG-WRAA 155
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 1-268 9.31e-15

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 74.46  E-value: 9.31e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   1 MDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLL 80
Cdd:COG0477   28 LDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPS--PELL 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100  81 LLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHWALRVTPGLGVVAVLL 160
Cdd:COG0477  106 IAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALG-WRWIFLINAPLGLLALVL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100 161 LFLVVREPPRGAVERHSDLPPLNPTSWWADLRALARNPSFVLSSLGFTAVAFVTGSLALWAPAFLLRSRVVLGETPPCLP 240
Cdd:COG0477  185 RLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLL 264

                        250       260
                 ....*....|....*....|....*...
gi 215490100 241 GDSCSSSDSLIFGLITCLTGVLGVGLGV 268
Cdd:COG0477  265 LLLLLLLLALLLALLLLLLLLLLLLLLA 292
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 1-371 4.15e-13

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 70.29  E-value: 4.15e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   1 MDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLL 80
Cdd:cd17319   17 LDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATS--LTSL 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100  81 LLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHWALRVTpglgvvavll 160
Cdd:cd17319   95 YVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFG-WRWAFIIE---------- 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100 161 lflvvrepprgaverhsDLPPLNPTSWWadlraLARNPSFVLSSLGFTAVAFVTGSLALWAPAFLLRSRVVlgetppclp 240
Cdd:cd17319  164 -----------------GLLGLLLAVLW-----WFYLRQVWGLALGYFGINYALYGLLTWLPTYLKQARGF--------- 212

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100 241 gdscsssDSLIFGLITCLTGVLGVGLGVEISRRLRHSNPRADPLVCATGLLGSAPFLFLSLACarGSIVATYIFIFIGET 320
Cdd:cd17319  213 -------SLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIGLLLAAVGLLLAYLT--TSPVVAVILLSLAGF 283

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 215490100 321 LLSMNWAIVADILLYVVIPTRRSTAEAFqIVLSHLLGDAGSPYLIGLISDR 371
Cdd:cd17319  284 GIGAASPVFWSLPADLLPGEAAATAGGL-INSGGNLGGFVAPLLIGYLVDA 333
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
1-225 7.67e-13

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 69.91  E-value: 7.67e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   1 MDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLL 80
Cdd:COG2223   19 GVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVS--YWLL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100  81 LLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHWALRVTPGLGVVAVLL 160
Cdd:COG2223   97 LLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFG-WRNAFLILGILLLVVAVL 175

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 215490100 161 LFLVVREPPRGAVERHSDLpplnptswWADLRALARNPSFVLSSLGFTAVAFVTGSLALWAPAFL 225
Cdd:COG2223  176 AWLFLRDPPAGAAAAAKAS--------LRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYL 232
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 4-126 9.00e-13

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 69.52  E-value: 9.00e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   4 FTVAGVLPDI-EQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLLLL 82
Cdd:cd17473   16 AAIAPALPAIaQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDS--LYALLA 93

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 215490100  83 TRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGS 126
Cdd:cd17473   94 SRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGG 137
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 1-145 5.61e-12

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 66.81  E-value: 5.61e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   1 MDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGEHFWLL 80
Cdd:cd17380   13 ADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLL 92

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 215490100  81 LLTRGLVGVGEA-SYSTIApTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHW 145
Cdd:cd17380   93 ILSRILLGLGEGvHFPSMT-SLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYG-WPS 156
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 5-145 1.70e-11

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 65.28  E-value: 1.70e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   5 TVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLLLLTR 84
Cdd:cd17474   17 IVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDS--FALLLAGR 94

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 215490100  85 GLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSkvkdMAGDWHW 145
Cdd:cd17474   95 ALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGG----LLAAISW 151
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 6-146 2.27e-11

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 64.91  E-value: 2.27e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   6 VAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPgeHFWLLLLTRG 85
Cdd:cd17504   15 LSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAP--NLPVLIAGRA 92

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 215490100  86 LVGVGEASYsTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHWA 146
Cdd:cd17504   93 LQGIGGAVF-PLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLG-WRWI 151
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 2-236 6.65e-11

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 63.55  E-value: 6.65e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100    2 DRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPgeHFWLLL 81
Cdd:TIGR00881  10 VRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFST--SLWVMA 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   82 LTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGDWHWALRVTPGLGVVAVLLL 161
Cdd:TIGR00881  88 ALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLIC 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100  162 FLVVREPPRG------------AVERHSDLPPLNPTSWWADLRALARNPSFVLSSLGFTAVAFVTGSLALWAPAFLLRSR 229
Cdd:TIGR00881 168 FLLLRDSPQScglppaeempneEPDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEK 247


                  ....*..
gi 215490100  230 VVLGETP 236
Cdd:TIGR00881 248 GFSKEKA 254
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
6-225 1.61e-10

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 62.58  E-value: 1.61e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   6 VAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLLLLTRG 85
Cdd:COG2807   37 VGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPS--VALLLAGTA 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100  86 LVGVGEASYSTIAPTLIADLFvADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHWALRVTPGLGVVAVLLLFLVV 165
Cdd:COG2807  115 LIGAGIAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALG-WRGALAVWALLALLALLLWLPLL 192

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100 166 REPPRGAVerhsdlpplnPTSWWADLRALARNPSFVLSSLGFTAVAFVTGSLALWAPAFL 225
Cdd:COG2807  193 RRRPAAAA----------AAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPIL 242
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 1-369 3.14e-10

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 61.46  E-value: 3.14e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   1 MDRFTVAGVLPDIEQFFNiGDSSSGLIQTVFISSY---MVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehF 77
Cdd:cd17316   13 YDFFLIGFVAPVLAAEFS-LGLSLLQTGLLFAAGFlgrPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPT--P 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100  78 WLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGD---WHWALRVtpglg 154
Cdd:cd17316   90 ILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGdwgWRILFLI----- 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100 155 vvavlllflvvrepprgaverhSDLPPLnptswwadLRALARnPSFVLSSLGFTAVAFVTGSLALWAPAFLLRSRVVLGE 234
Cdd:cd17316  165 ----------------------GALPAL--------LALLLR-RRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPA 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100 235 TppclpgdscSSSDSLIFGLITCLTGVLGVGLGVEISRRLrhsnpradplVCATGLLGSAPFLFLsLACARGSIVATYIF 314
Cdd:cd17316  214 T---------SSLYLLLISLGALVGALIAGLLSDRIGRKK----------TLVIGLILSGILALP-LFYLLSGSPTLLLL 273

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 215490100 315 IFIGETLLSMNWAIVADILLYVVIPTR-RSTAEAFQIVLSHLLGdAGSPYLIGLIS 369
Cdd:cd17316  274 LLFILSFFVGGVWGALYAYLAELFPTEvRATGVGLSYNLGRLGG-GGAPPLIALLL 328
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
5-225 3.32e-10

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 61.41  E-value: 3.32e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   5 TVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLLLLTR 84
Cdd:COG0738   26 LWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPS--YPLLLLAL 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100  85 GLVGVGEASYSTIAPTLIADLFvADQRSRMLSIFYFAIPVGSGLGYIAGSKV--KDMAGDWHWALRVTpGLGVVAVLLLF 162
Cdd:COG0738  104 FLLGLGLGLLDVAANPYVAALG-PETAASRLNLLHAFFSLGALLGPLLGGLLilLGLSLSWHLPYLIL-AVLLLLLALLF 181

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 215490100 163 LVVREPPRGAVERhsdlpplNPTSWWADLRALARNPSFVLSSLGFTAVAFVTGSLALWAPAFL 225
Cdd:COG0738  182 LRSKLPEIEEEEE-------EAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYL 237
Sugar_tr pfam00083
Sugar (and other) transporter;
2-145 7.39e-10

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 60.75  E-value: 7.39e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100    2 DRFTVAGVLPDIEQFFNIG-------DSSSGLIQTVFISSYMVLAPV----FGYLGDRYNRKYLMCGGIAFWSLVTLGSS 70
Cdd:pfam00083  15 DTGVIGAFLTLIDFFKNFGlsksvssLAALSVLSGLIVSIFSVGCFIgslfAGKLGDRFGRKKSLLIANVLFVIGAVLQG 94

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 215490100   71 FIPG-EHFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGDWHW 145
Cdd:pfam00083  95 AAKGkWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGLNKTSNSDGW 170
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 10-145 2.09e-09

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 59.11  E-value: 2.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100  10 LPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLLLLTRGLVGV 89
Cdd:cd17321   19 LPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPS--LAFLIAARALQGI 96

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 215490100  90 GEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHW 145
Cdd:cd17321   97 GAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFG-WRW 151
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 6-129 3.55e-09

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 58.34  E-value: 3.55e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   6 VAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLLLLTRG 85
Cdd:cd17478   15 LPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPN--YWLLLLLVA 92

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 215490100  86 LVGVGEASYSTIAPTLIADLFvADQRSRMLSIFYFAIPVGSGLG 129
Cdd:cd17478   93 LAGIGSAAFHPEGARLASQAA-GGRRGLAMSIFSVGGNLGFALG 135
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 7-145 6.12e-09

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 57.59  E-value: 6.12e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   7 AGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPgeHFWLLLLTRGL 86
Cdd:cd17323   19 SPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAP--NIAMLIILRFL 96

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 215490100  87 VGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDmAGDWHW 145
Cdd:cd17323   97 QGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQ-SLGWRW 154
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
13-141 9.53e-09

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 57.22  E-value: 9.53e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100  13 IEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGEHFWLLLLTRGLVGVGEA 92
Cdd:COG2211  255 FKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLG 334

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 215490100  93 SYSTIAPTLIADLFVADQ-------RSRMLSIFYFAIPVGSGLGYIAGSKVKDMAG 141
Cdd:COG2211  335 AILVLPWAMLADVVDYDEwktgrrrEGLYFGIFTFAIKLGQALAGALAGLLLALFG 390
MFS_SLCO4_OATP4 cd17403
Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of ...
 4-331 1.15e-08

Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4 (SLCO4) or Organic anion transporting polypeptide 4 (OATP4) family contains two families: OATP4A and OATP4C, each containing one mammalian member, OATP4A1 and OATP4C1, respectively. OATP4A1 (encoded by SLCO4A1), is ubiquitously expressed and mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4C1 (encoded by SLCO4C1) is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate, cAMP, and uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs). The SLCO4/OATP4 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340961 [Multi-domain]  Cd Length: 420  Bit Score: 56.88  E-value: 1.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   4 FTVAGVLP----DIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNR-KYLMCGGIafwsLVTLGS--SFIPgeH 76
Cdd:cd17403   17 MVVNGFVNvsitTIEKRFGLTSTQTGLIASSYDIASVLLLLFVSYFGGRGHKpRWLGIGAF----IMGIGSlvFALP--H 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100  77 FWLLLLTRGLVGVGEASYSTIAPTLIaDLFVADQRSRM-LSIFYFAIPVGSGLGYIAGSKVKDMAGDWhwalrvtpglgv 155
Cdd:cd17403   91 FTVFILAQLLHGAGATPLYTLGVTYL-DENVSTKMSPLyIGIFYAMAILGPAIGYVLGGFLLNLYTDI------------ 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100 156 vavlllflvvrepprGAVERHSDLPPLNPT---SWW---------ADLRA---LARNPSFVLSSLGFTAVAFVTGSLALW 220
Cdd:cd17403  158 ---------------DQVDSELGLTPDDPRwvgAWWlgflisgalALIIAfplLGFPPTFMFLNLAGASEGMLLAGFATF 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100 221 APAFLlrsrvvlgETPPCLPgdscSSSDSLIFGLITCLTGVLGVGLGVEISRRLRHSNPRADPLVCATGLLGSAPFLFLS 300
Cdd:cd17403  223 LPKLI--------ESQFSLS----ASLAALLVGVVVVPGGILGTFLGGLIVKKLKLKCKGILKFCIVCSIVAFLFSFILL 290

                        330       340       350
                 ....*....|....*....|....*....|.
gi 215490100 301 LACARGSIVAtyIFIFIGETLLSMNWAIVAD 331
Cdd:cd17403  291 IYCPNAPFAG--VTVPYGNSPLEGTSNLTST 319
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 26-131 4.88e-08

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 54.51  E-value: 4.88e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100  26 LIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPgeHFWLLLLTRGLVGVGEASYSTIAPTLIADL 105
Cdd:cd17317   29 LVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSP--SYELFLVLRFLVGVTSAGIFTVGFVLGMEI 106

                         90       100       110
                 ....*....|....*....|....*....|
gi 215490100 106 FVADQRSRMLSIFYFAIPVG----SGLGYI 131
Cdd:cd17317  107 VGPKYRSFVGILFGLFWALGymllALLAYL 136
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 15-377 1.29e-07

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 53.39  E-value: 1.29e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100  15 QFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIpgEHFWLLLLTRGLVGVGEASY 94
Cdd:cd17329   28 QQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFA--HSPWLFAIALVLTGFGGGLF 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100  95 STIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGDWhwalrVTPGLGVVAVLLLFLVVREPPRGAVE 174
Cdd:cd17329  106 EPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRL-----LFLAAAVLFLLAALVLLFLLPETRPK 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100 175 RHSDLPPLNPTSWwadlRALARNPSFVLSSLGFTAVAFVTGSLALWAPAFLLrsrvvlgetppclpgDSCSSSDSLIfGL 254
Cdd:cd17329  181 RRAAEKTEILRGY----KIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVV---------------EILGLGESLL-GL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100 255 ITCLTGVLGVGLGVEISRRLRHSNPRADPLVCAtgLLGSAPFLFLSLACARGSIVATYIFIFIGETLLS-MNWAIVADIl 333
Cdd:cd17329  241 LLALNALLIVLLQFPVARLVERFRLRKILMIGI--LLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFpAVQTLVAAL- 317

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 215490100 334 lyVVIPTRRSTAEAFQIVLShlLGDAGSPYLIGLISDRLRRNWP 377
Cdd:cd17329  318 --APPDKRGSYMGFYALAWG--LGRAIGPLVGGLLLDLLGPGLP 357
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 6-147 2.64e-07

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 52.57  E-value: 2.64e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   6 VAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNR-KYLMCGGIAFwSLVTLGSSFIPgeHFWLLLLTR 84
Cdd:cd17359   20 INGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRrKTLLISAVLF-FISALGSAFSP--NFTIFIIAR 96

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100  85 GLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGD-------WHWAL 147
Cdd:cd17359   97 IIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIVNYLIANAGGAdwlgaegWRWML 166
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
 8-299 3.20e-07

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 460821 [Multi-domain]  Cd Length: 526  Bit Score: 52.59  E-value: 3.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100    8 GVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNR-KYLMCGGIafwsLVTLGS--SFIPgeHFWLLLLTR 84
Cdd:pfam03137  22 SSITTIEKRFGLPSSLSGLISSSYDIGNLLLIVFVSYFGGKGHRpRWIGVGAL----LMGLGSllFALP--HFLSFFLGQ 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   85 GLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGDWH-WALRVTPG----------- 152
Cdd:pfam03137  96 LLLGIGGTPIYTLGISYIDDNVKKKNSPLYLGILYAVRVLGPALGFLLGSLCLRIYVDIGkVSITLTPKdprwvgawwlg 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100  153 -----------------------LGVVAVLLLFLVVREPPRGAVERHSDLPPLNPTSW--WADLRALARNPSFVLSSLGF 207
Cdd:pfam03137 176 fliagllllltaipffffpkslpGAAKRRAKKKKEPHSQDIADLKKTKSLKKLGPSLKdfPKALKRLLKNPVYMLLTLAS 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100  208 TAVAFVTGSLALWAPAFLlrsrvvlgETPPclpgdSCSSSD-SLIFGLITCLTGVLGVGLGVEISRRLRHSNPRADPLVC 286
Cdd:pfam03137 256 VFEFLLIAGYATFLPKYI--------ETQF-----GLSASTaNLLTGVVAIPGAALGILLGGLIIKKFKLSAKGLAKFNV 322

                         330
                  ....*....|....*.
gi 215490100  287 ATG---LLGSAPFLFL 299
Cdd:pfam03137 323 ITSlvsLLLSLLLFFL 338
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 9-134 4.18e-07

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 51.83  E-value: 4.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   9 VLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLLLLTRGLVG 88
Cdd:cd17489   18 VLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATS--VALLLVLRLIHG 95

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 215490100  89 VGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGS 134
Cdd:cd17489   96 IGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGL 141
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 9-147 4.99e-07

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 51.43  E-value: 4.99e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   9 VLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLLLLTRGLVG 88
Cdd:cd17365   21 VAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQS--VLQLALLRFLTG 98

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 215490100  89 VGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHWAL 147
Cdd:cd17365   99 LGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFG-WRSVF 156
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 19-134 9.21e-07

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 50.62  E-value: 9.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100  19 IGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGssFIPGEHFWLLLLTRGLVGVGEASYSTIA 98
Cdd:cd17370  231 LSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLG--FALGSSLWLLLLGFILWGLYMGAQESIE 308

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 215490100  99 PTLIADLFVADQRSRMLSIFYFaipvGSGLGYIAGS 134
Cdd:cd17370  309 RAAVADLVPAELRGTAYGLFNT----VVGIGWLLAS 340
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 10-117 1.54e-06

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 50.27  E-value: 1.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100  10 LPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPgeHFWLLLLTRGLVGV 89
Cdd:cd17320   22 LPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALAS--SIEQLLIARFLQGL 99

                         90       100
                 ....*....|....*....|....*...
gi 215490100  90 GEASYSTIAPTLIADLFVADQRSRMLSI 117
Cdd:cd17320  100 GAAAGSVVARAIVRDLYSGAELAKIFSL 127
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 1-299 1.56e-06

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 50.05  E-value: 1.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100    1 MDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFipGEHFWLL 80
Cdd:TIGR00895  31 YDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCAL--ATNVTQL 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   81 LLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVG-SGLGYIAGSKVKDMagDWHWALRVTPGLGVVAVL 159
Cdd:TIGR00895 109 LILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGaAVGGFLAGWLIPVF--GWRSLFYVGGIAPLLLLL 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100  160 LLFLVVREPPRGAVERHSD-----LPPLNPTSWWADLRALARNPSFVLSSLGFTAVAF----VTGSLALWAPAFLLRSRV 230
Cdd:TIGR00895 187 LLMRFLPESIDFLVSKRPEtvrriVNAIAPQMQAEAQSALPEQKSTQGTKRSVFKALFqgktARITVLLWLLYFMLLVGV 266

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 215490100  231 --VLGETPPCLPGDSCSSSDSLIFGLITCLTGVLGVGLGVEISRRLRhsnpradPLVCATGLLGSAPFLFL 299
Cdd:TIGR00895 267 yfLTNWLPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLG-------PRVTALLLLLGAVFAVL 330
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 25-145 2.64e-06

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 49.63  E-value: 2.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   25 GLIQTVFISSYMVLAPVFGYLGDRYNRKYLMcggiaFWS-LVTLGSSFIPG--EHFWLLLLTRGLVGVGEASYSTIAPTL 101
Cdd:TIGR00898 130 DLTQSCFFVGVLLGSFVFGYLSDRFGRKKVL-----LLStLVTAVSGVLTAfsPNYTVFLVFRLLVGMGIGGIWVQAVVL 204

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 215490100  102 IADLFVADQRsRMLSIFYFaipVGSGLGYIAGSKVKDMAGDWHW 145
Cdd:TIGR00898 205 NTEFLPKKQR-AIVGTLIQ---VFFSLGLVLLPLVAYFIPDWRW 244
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 5-143 6.91e-06

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 47.95  E-value: 6.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   5 TVAGVLPDIEQFFNIGDSSSglIQTVFISSYMVLAPV----FGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLL 80
Cdd:cd17315   15 VINGALLYIAKDLGFGLSTS--LQGLVVSSLLLGAAIgslfGGPLADRFGRRKSLLIAAVLYVIGALLSALAPN--VWVL 90

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 215490100  81 LLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGDW 143
Cdd:cd17315   91 IVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPPGW 153
MFS_SLCO5_OATP5 cd17404
Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of ...
 7-134 7.36e-06

Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 5 (SLCO5) or Organic anion transporting polypeptide 5 (OATP5) family contains only one subfamily, OATP5A, which contains only one mammalian member OATP5A1 (encoded by SLCO5A1). Deletion of the SLCO5A1 gene has been implicated in the pathogenesis of Mesomelia-synostoses syndrome (MSS), a rare autosomal-dominant disorder characterized by mesomelic limb shortening, acral synostoses, and multiple congenital malformations. OATP5A1 may be a non-classical OATP which is involved in biological processes that require the reorganization of the cell shape, such as differentiation and migration. It seems to affect intracellular transport of drugs and may participate in chemoresistance of small cell lung cancer (SCLC by sequestration), rather than mediating cellular uptake. The SLCO5/OATP5 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340962 [Multi-domain]  Cd Length: 425  Bit Score: 48.12  E-value: 7.36e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   7 AGVLPDIEQFFNIGDSSSGLIqtvfISSY---MVLAPVF-GYLGDRYNR-KYLMCGGIafwsLVTLGSSFIPGEHFwlLL 81
Cdd:cd17404   23 NSVITTIEKRYSLKSSESGLI----VSSYeigSLLTVVFvSYFGGRGHRpRWIAVGGV----LIALGSFLFSLPHF--FI 92

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 215490100  82 LTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGS 134
Cdd:cd17404   93 LAQILIGMGGTPIFTLGTTYLDDHVKKESSSLYLAIMYVMGALGPAAGFLLGG 145
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 5-145 8.02e-06

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 47.96  E-value: 8.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   5 TVAGV-LPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPgeHFWLLLLT 83
Cdd:cd17503   13 TIVNVaLPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAP--NLASLIIF 90

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 215490100  84 RGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHW 145
Cdd:cd17503   91 RILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLS-WRW 151
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 1-225 9.87e-06

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 47.68  E-value: 9.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   1 MDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLL 80
Cdd:cd17371   13 FDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQN--YWQL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100  81 LLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKV-KDMAGDWHW-ALRVTPGLGVVAV 158
Cdd:cd17371   91 LILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLfPLLPPEIAWrVLFLLGALPALLV 170

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 215490100 159 LLLFLVVREPPRGAVERHSDLPPLNPTSWWADLRALARNPsFVLSSLGFTAVAFVTGSLALWAPAFL 225
Cdd:cd17371  171 LFIRRFVKEPPQWQAARAARRHFADRPSLRELFSPPLLRT-TLLASLLATGALGGYYGITTWLPSYL 236
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 19-141 2.42e-05

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 46.43  E-value: 2.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100  19 IGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLLLLTRGLVGVGEASYSTIA 98
Cdd:cd17489  224 RGISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGS--PWMLLLAAVLYGLGFGLLFPAL 301

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 215490100  99 PTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAG 141
Cdd:cd17489  302 QALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFG 344
MFS_SLCO_OATP cd17336
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ...
 8-134 2.82e-05

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340894 [Multi-domain]  Cd Length: 411  Bit Score: 46.08  E-value: 2.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   8 GVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIpgeHFWLLLLTrgLV 87
Cdd:cd17336   24 STITTIEKRFGLSSSQSGLILSANDIGQLLAVLLVSYFGGRGHRPRWIGIGSILMGLGCFLLALP---HFLFVGQF--LL 98

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 215490100  88 GVGEASYSTIAPTLIADlFVADQRSRMLSIFYFAIPV-GSGLGYIAGS 134
Cdd:cd17336   99 GIGSSPLYTLGITYIDD-NVSKKNSPLYIGILYAMRVlGPALGFLLGS 145
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 6-145 3.20e-05

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 45.63  E-value: 3.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   6 VAGVLPDIEQFFNiGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLLLLTRG 85
Cdd:cd17502   15 VATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPN--MTMLIVGRA 91

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100  86 LVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHW 145
Cdd:cd17502   92 IQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLS-WRW 150
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 7-145 5.12e-05

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 45.70  E-value: 5.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   7 AGVLPDIEQffNIGDSS-SGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFW---SLVTLGSSFIPGehfwlLLL 82
Cdd:cd06179   18 AAVLPFIVA--DLGPSSnSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGvvgSIVAGTAKSVNM-----LIG 90

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 215490100  83 TRGLVGVGeASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLG-YIAGSKVKDMAGDWHW 145
Cdd:cd06179   91 GQALIGIG-AGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGpLIAGALVEANAAGWRW 153
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 3-151 6.34e-05

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 44.96  E-value: 6.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   3 RFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFipGEHFWLLLL 82
Cdd:cd17312   19 RKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGF--STSLWFFAV 96

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 215490100  83 TRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDmAGDWHWALRVTP 151
Cdd:cd17312   97 LWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLAS-YYGWRAAFLVPG 164
MFS_SVOPL cd17442
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ...
 1-150 6.50e-05

Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341000 [Multi-domain]  Cd Length: 375  Bit Score: 44.80  E-value: 6.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   1 MDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPgEHFWLL 80
Cdd:cd17442   15 MEIMLLAVVSPEIRCEWHLEDWQVALVTTMVFFGYMVFSILLGLLADRYGRWKILLLSFVWGAYFSLLTSFAP-SYIWFV 93

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 215490100  81 LLtRGLVGVGEASYSTiAPTLIADLFVADQRSRML---SIFYFAipvGSGLGYIAGSKVKDMAGdWHWALRVT 150
Cdd:cd17442   94 FL-RCMVGCGVSGHSQ-GLIIKTEFLPTKYRGYMLplsQIFWLA---GSLLIIGLASVVIPTLG-WRWLIRFA 160
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
4-147 1.17e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 44.10  E-value: 1.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   4 FTVAGVLPDI-EQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGeHFWLLLL 82
Cdd:COG2223  222 IGFSSWLPPYlVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALG-SLWLFLV 300

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 215490100  83 TRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGDWHWAL 147
Cdd:COG2223  301 LFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAF 365
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 4-116 1.17e-04

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 44.58  E-value: 1.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100    4 FTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGEHFWllLLT 83
Cdd:TIGR01299 184 FVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFF--LFC 261

                          90       100       110
                  ....*....|....*....|....*....|...
gi 215490100   84 RGLVGVGEASYSTIAPTLIADLFVADQRSRMLS 116
Cdd:TIGR01299 262 RLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLS 294
MFS_DtpA_like cd17346
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ...
 16-146 3.11e-04

Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340904 [Multi-domain]  Cd Length: 399  Bit Score: 42.95  E-value: 3.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100  16 FFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRY--NRKYLMCGGIafwsLVTLG--SSFIPGEHFWLLLLTRGLVGVGE 91
Cdd:cd17346   34 GDGFSEADAASIYGAYTALVYLTPIIGGWLADKVlgARRTVFIGGI----LMALGylLLALSPFSVSMLYLGLALIIVGN 109

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 215490100  92 ASYSTIAPTLIADLFVADQ--RSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHWA 146
Cdd:cd17346  110 GLFKPNISSLVGKLYDENDprRDSGFSIFYMGINLGAFLAPLLCGTLGDNYG-YHYG 165
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 3-225 4.46e-04

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 42.26  E-value: 4.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   3 RFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPgeHFWLLLL 82
Cdd:cd17355   19 RYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALAT--SLWQLYL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100  83 TRGLVGVGEASYSTIAPTLIADLFVADQ-RSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHWALRVTPGLGVVAVLLL 161
Cdd:cd17355   97 LWGLLGGGGAGTLAAVAFATVAAWWFERrRGLALGILTAGGGLGSLVFLPLGAALIEAFG-WRTALLVLALLALLVLVPV 175

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 215490100 162 FLVVREPPRGAVERHSDLPPlnPTSWWADLRALARNPSFVLSSLGFTAVAFVTGSLALWAPAFL 225
Cdd:cd17355  176 LLLLRRRPADLALRAYDDAS--PASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYL 237
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
 11-131 4.86e-04

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 42.24  E-value: 4.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100  11 PDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGEhFWLLLLTRGLVGVG 90
Cdd:cd17356   34 ADNTGTYYPSSSRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIGAIIQVAAIGK-WYQLIVGRIIAGLG 112

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 215490100  91 EASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYI 131
Cdd:cd17356  113 VGFASVLVPVYQSEVAPKHIRGTLVSLYQLAITIGILVAYC 153
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 10-130 8.07e-04

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 41.45  E-value: 8.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100  10 LPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGEHFWLLLLTRGLVGV 89
Cdd:cd17318   44 LPVEAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGL 123

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 215490100  90 GEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGY 130
Cdd:cd17318  124 AQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVIAM 164
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
 1-150 8.50e-04

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 41.37  E-value: 8.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   1 MDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPgEHFWLL 80
Cdd:cd17372   13 MEMMLLSFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAP-NYMWLI 91

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100  81 LLtRGLVGVGEASYSTIApTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHWALRVT 150
Cdd:cd17372   92 IL-RCLVGLGLGGGPQLA-SWYLEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLG-WRWLLAFS 158
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 4-231 9.77e-04

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 41.15  E-value: 9.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   4 FTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRK-YLMCGGIAFWSLVTLgssFIPGEHFWLLLL 82
Cdd:cd17333   13 ALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRrTLILGLLLISLALAL---IFATPSIYLFVV 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100  83 TRGLVGVGEASYSTIAPTLIADLFVADQRSRMlSIFYFAIPVGSGLGYIAGSKVKDMAGDWHWAlRVTPGLGVVAVLLLF 162
Cdd:cd17333   90 LMFLAGLGAGILDTGANTFVGALFEESSATRL-NVLHGFFGLGALIGPLIATSLLTSELSWSWA-YLIIGLIYLLLAILI 167

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 215490100 163 LVVREPPRgaveRHSDLPPLNPTSWWADLRALARNPSFVLSSLGFTAVAFVTGSLALWAPAFLLRSRVV 231
Cdd:cd17333  168 LLTLFPEL----PSARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHV 232
MFS_SV2A cd17439
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...
 4-116 1.14e-03

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340997 [Multi-domain]  Cd Length: 478  Bit Score: 41.17  E-value: 1.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   4 FTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLLLLT 83
Cdd:cd17439   16 FVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQG--YGTFLFC 93

                         90       100       110
                 ....*....|....*....|....*....|...
gi 215490100  84 RGLVGVGEASYSTIAPTLIADLFVADQRSRMLS 116
Cdd:cd17439   94 RLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLS 126
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 10-146 1.19e-03

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 41.09  E-value: 1.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100  10 LPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGEHFwlLLLTRGLVGV 89
Cdd:cd17476   21 LPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIF--FIICRALQGL 98

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 215490100  90 GEASYSTIAPTLIADLFVADQRSRM-LSIFYFAIPVGSGLGYIAGSKVKDMAGdWHWA 146
Cdd:cd17476   99 GPAFLLPNAMALLGRTYPPGPRKNIvFSLFGATAPLGFALGGVFGGLFAQLAW-WPWI 155
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 9-129 1.34e-03

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 40.64  E-value: 1.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   9 VLPD-IEQFFNIGDSS--SGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFwSLVTLGSSFIPGeHFWLLLLTRG 85
Cdd:cd17330   18 VLPFyVREFNKLGASGyyVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAG-SAVSYVLLGLSR-NLWLLFLARF 95

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 215490100  86 LVGVGeASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLG 129
Cdd:cd17330   96 LDGLT-GGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILG 138
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
 41-145 1.78e-03

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 40.41  E-value: 1.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100  41 VFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYF 120
Cdd:cd17362   58 VAGALIDRLGRRKELILAALLYLVGSLVTGLAPS--YPVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVSLKEL 135

                         90       100
                 ....*....|....*....|....*
gi 215490100 121 AIPVGSGLGYIAGSKVKDMAGDWHW 145
Cdd:cd17362  136 FIVLGILLGYVSGYAFADVVGGWRY 160
MFS_POT cd06175
Proton-coupled oligopeptide transporter (POT) family of the Major Facilitator Superfamily of ...
 2-147 2.25e-03

Proton-coupled oligopeptide transporter (POT) family of the Major Facilitator Superfamily of transporters; The Proton-coupled oligopeptide transporter (POT) family is present across all major kingdoms of life and is known by a variety of names. It is referred to as the Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) in plants, and in addition to POT, it is also known as the Peptide transporter (PepT/PTR) or Solute Carrier 15 (SLC15) family in animals. Members of this family are proton-driven symporters involved in nitrogen acquisition in the form of di- and tripeptides. Plant members transport other nitrogenous ligands including nitrate, the plant hormone auxin, and glucosinolate compounds that are important for seed defense. POT proteins exhibit substrate multispecificity, with one transporter able to recognize as many as 8,400 types of di/tripeptides and certain peptide-like drugs. The POT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340865 [Multi-domain]  Cd Length: 422  Bit Score: 40.11  E-value: 2.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   2 DRFTVAGVLPDIEQFFNIG----DSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKY--------LMCGGIAFWSLVTLGS 69
Cdd:cd06175   11 ERFTFYGIGANLVPFLTGAlglgNAQAANVVLNFLGTSYVTPLFGGWIADTFLGRYrtiligaaIYAVGVAILTVSTIPP 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100  70 SFIP------------GEHFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLS---IFYFAIPVGSGLGYIAGS 134
Cdd:cd06175   91 GLRPlrcnpshceqasGIQLTGFYAALYLIALGTGGVKANVSPLGADQFDERGPSKTQSffnWFYFCINVGSLLAMLGTP 170

                        170
                 ....*....|...
gi 215490100 135 KVKDMAGdWHWAL 147
Cdd:cd06175  171 YIQDNVG-WAAAY 182
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 26-129 2.67e-03

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 39.92  E-value: 2.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100  26 LIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIpgEHFWLLLLTRGLVGVGEASYSTIAPTLIADL 105
Cdd:cd17327   45 WGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAV--KNFGGLIALRFFLGLFESGVFPGFILYLGMW 122

                         90       100
                 ....*....|....*....|....
gi 215490100 106 FVADQRSRMLSIFYFAIPVGSGLG 129
Cdd:cd17327  123 YKREEQAKRIAFFYAAAGLGSIFG 146
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 6-147 2.88e-03

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 39.56  E-value: 2.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   6 VAGVLPDIEQFFNIGDSSSGLiQTVFISSYMVLAPVF----GYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPgeHFWLLL 81
Cdd:cd17360   16 ISGALLYIKDDLGEVVLSTGW-QELIVSSTVAGAAVGaaigGWLNDRFGRRPCILLADALFTIGAIVMAAAP--NKEVLI 92

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 215490100  82 LTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGDWHWAL 147
Cdd:cd17360   93 VGRVLVGLGVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITGGQFVAYVINGAFSYLPGGWRWML 158
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
 4-116 2.89e-03

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 39.78  E-value: 2.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   4 FTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLLLLT 83
Cdd:cd17363   16 FVVGFVLPSAEKDMCLSNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQG--YGFFLFC 93

                         90       100       110
                 ....*....|....*....|....*....|...
gi 215490100  84 RGLVGVGEASYSTIAPTLIADLFVADQRSRMLS 116
Cdd:cd17363   94 RLLSGIGIGGSIPIVFSYFAEFLAREKRGEHLS 126
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 4-105 3.55e-03

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 39.51  E-value: 3.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   4 FTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGEHFWLLLLT 83
Cdd:cd17332  238 NIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPPGNLVLILVL 317

                         90       100
                 ....*....|....*....|..
gi 215490100  84 RGLVGVGEASYSTIAPTLIADL 105
Cdd:cd17332  318 AVLAGIGYGGANLLPWAMLADV 339
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 35-400 3.76e-03

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 39.53  E-value: 3.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100  35 YMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLLLLtrGLVGVGeASYSTIAPT---LIADLFVADQR 111
Cdd:cd17475   44 VAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGS--YPVLLV--LLFLVG-AGYGSVQPGggrAIMRWFPPRER 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100 112 SRMLSIFYFAIPVGSGLGYIAGSKVKDMAGdWHWALRVTPGLGVVAVLLLFLVVREPPRGAVERHSdlpplnPTSWWADL 191
Cdd:cd17475  119 GLAMGIRQTGVPLGGALAAALLPPLALHYG-WRAAFVVAGLVSILAAVLFWLFYREPPAASAATES------ASTLLRSL 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100 192 RALARNPSFVLSSL-GFTAVAFVTGSLALWAPafLLRSRVVLGETppclpgdscsssDSLIFGLITCLTGVLG-VGLGVe 269
Cdd:cd17475  192 KEVLRNRDVWLIAIaGALLVAPQFALLTFLLL--FLHDHLGLSVV------------AAGALLAVAQLGGALGrIGLGR- 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100 270 ISRRLRHSNPRadPLVCATGLLGSAPFLFLSLACARGSIVATY-IFIFIGetLLSMNWAIVADILLYVVIPTRRS-TAEA 347
Cdd:cd17475  257 VSDRVFGGRRR--PVLVITAAIAAAALLVLSLLSPGTPLWLLVlLLILLG--LFAIGWNGLYLTLVAESAGPEQAgTALG 332

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 215490100 348 FQIVLShLLGDAGSPYLIGLISDRLrRNWPPSFlsefralqFSLMLCAFVGAL 400
Cdd:cd17475  333 LANTIN-FIGIAIGPPLFGLLVDAT-HSYAPAW--------LALALLLVLAAL 375
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
36-333 4.18e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 39.50  E-value: 4.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100  36 MVLAPVFGYLGDRYNRK------YLMCGGI---AFWSLVTLGSSFIPGEHFWLLLLTRGLVGVG----EASYSTIAPTLI 102
Cdd:COG2211   60 AITDPLIGALSDRTRTRwgrrrpWILIGAIplaLSFVLLFTAPDLSPTGKLIYALVTYLLLGLAytlvNIPYSALGAELT 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100 103 ADlfvADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGD-----WHWALRVTPGLGVVAVLLLFLVVREPPRgaverhs 177
Cdd:COG2211  140 PD---YEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGdaalgYRLTALIFAVLGLLAFLLTFFGTKERPV------- 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100 178 dlPPLNPTSWWADLRALARNPSFVLSslgFTAVAFVTGSLALWAPAFLLRSRVVLGEtppclpgdscSSSDSLIFGLITC 257
Cdd:COG2211  210 --PEEEKVSLKESLKALLKNRPFLLL---LLAYLLFFLALALVAALLLYYFKYVLGL----------SAALVGLLLALYF 274

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100 258 LTGVLGVGLGVEISRRLrhsnPRADPLVCATGLLGSAPFLFLSLacARGSIVATYIFIFIGE----TLLSMNWAIVADIL 333
Cdd:COG2211  275 LAALLGAPLWPRLAKRF----GKKKAFIIGLLLAALGLLLLFFL--GPGNLWLLLVLAALAGiglgAILVLPWAMLADVV 348
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 5-134 4.34e-03

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 39.48  E-value: 4.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   5 TVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLM----CGGIAFWSLVTLGSSFipgehfWLL 80
Cdd:cd17358   24 ALPSLMSDNSLSLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLlisaIPCILGWLLIAFAKDV------WML 97

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 215490100  81 LLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGS 134
Cdd:cd17358   98 YLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGS 151
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
 11-119 4.44e-03

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 39.34  E-value: 4.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   11 PDIEQFFNIGDSSSGLIQTVFISS----YMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGEHFWLLLLTRGL 86
Cdd:TIGR00894  61 NELDNIKNPNFKWSGALQGLILSShfygQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVI 140

                          90       100       110
                  ....*....|....*....|....*....|...
gi 215490100   87 VGVGEASYSTIAPTLIADLFVADQRSRMLSIFY 119
Cdd:TIGR00894 141 QGLAQGSVSPATHKIIVKWAPPKERSRLLGMST 173
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
 1-116 6.34e-03

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 38.75  E-value: 6.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100   1 MDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLL 80
Cdd:cd17438   13 VEVFVVGFVLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQG--YGAF 90

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 215490100  81 LLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLS 116
Cdd:cd17438   91 LFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEHLS 126
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 28-145 6.46e-03

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 38.43  E-value: 6.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490100  28 QTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGehFWLLLLTRGLVGVGEASYSTIAPTLIADLfv 107
Cdd:cd17374   41 QSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPT--FPVYCVLRFLAGFAVSGISINTLILGTEW-- 116

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 215490100 108 ADQRSRMLSIFYFAIPVGSGLGYIAGskVKDMAGDWHW 145
Cdd:cd17374  117 TTPRHRALAITLTSCFFSIGQMLLAG--LAYAIRDWRL 152
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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