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Conserved domains on  [gi|294337038|ref|NP_001135932|]
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ankyrin repeat and SOCS box protein 10 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
114-358 5.54e-35

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 131.23  E-value: 5.54e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 114 EELTTPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPG 192
Cdd:COG0666   52 ALGALLLLAAALAGDLLVALLLLAAGADINaKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNG 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 193 TLECAELLLRFGARVDGRSEEEEeTPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLlaacdvrcqsitdaeattar 272
Cdd:COG0666  132 NLEIVKLLLEAGADVNAQDNDGN-TPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPL-------------------- 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 273 clqlcslllsagadadaadqdkqrplHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHcalqgpaAALAQSPEHVVRA 352
Cdd:COG0666  191 --------------------------HLAAENGHLEIVKLLLEAGADVNAKDNDGKTALD-------LAAENGNLEIVKL 237


                 ....*.
gi 294337038 353 LLNHGA 358
Cdd:COG0666  238 LLEAGA 243
SOCS super family cl02533
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 383-401 2.01e-03

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


The actual alignment was detected with superfamily member cd03723:

Pssm-ID: 470605  Cd Length: 48  Bit Score: 35.88  E-value: 2.01e-03
                         10
                 ....*....|....*....
gi 294337038 383 QPRSLQHLSRCALRSHLEG 401
Cdd:cd03723    2 TPRSLQHLCRCAIRKLLGS 20
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
114-358 5.54e-35

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 131.23  E-value: 5.54e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 114 EELTTPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPG 192
Cdd:COG0666   52 ALGALLLLAAALAGDLLVALLLLAAGADINaKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNG 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 193 TLECAELLLRFGARVDGRSEEEEeTPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLlaacdvrcqsitdaeattar 272
Cdd:COG0666  132 NLEIVKLLLEAGADVNAQDNDGN-TPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPL-------------------- 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 273 clqlcslllsagadadaadqdkqrplHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHcalqgpaAALAQSPEHVVRA 352
Cdd:COG0666  191 --------------------------HLAAENGHLEIVKLLLEAGADVNAKDNDGKTALD-------LAAENGNLEIVKL 237


                 ....*.
gi 294337038 353 LLNHGA 358
Cdd:COG0666  238 LLEAGA 243
Ank_2 pfam12796
Ankyrin repeats (3 copies);
152-245 7.74e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 83.63  E-value: 7.74e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038  152 LHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFgarVDGRSEEEEETPLHVAARLGHVELA 231
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH---ADVNLKDNGRTALHYAARSGHLEIV 77

                          90
                  ....*....|....
gi 294337038  232 DLLLRRGACPDARN 245
Cdd:pfam12796  78 KLLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 148-334 4.33e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 64.66  E-value: 4.33e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 148 GRTALHeacAAGHTAC------VHVLLVAGADPNIADQDGKRPLHLC-RGPGTLECAELLLRFGARVDGRSeEEEETPLH 220
Cdd:PHA03095  47 GKTPLH---LYLHYSSekvkdiVRLLLEAGADVNAPERCGFTPLHLYlYNATTLDVIKLLIKAGADVNAKD-KVGRTPLH 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 221 VAARlG---HVELADLLLRRGACPDARNAEGWTPL-----------------------LAACDVRCQSITDAEATTARCL 274
Cdd:PHA03095 123 VYLS-GfniNPKVIRLLLRKGADVNALDLYGMTPLavllksrnanvellrllidagadVYAVDDRFRSLLHHHLQSFKPR 201

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 294337038 275 QL-CSLLLSAGADADAADQDKQRPLHLA-----CRRGhaaVVELLLSCGVSANTMDYGGHTPLHCA 334
Cdd:PHA03095 202 ARiVRELIRAGCDPAATDMLGNTPLHSMatgssCKRS---LVLPLLIAGISINARNRYGQTPLHYA 264
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 148-176 6.17e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.88  E-value: 6.17e-05
                           10        20
                   ....*....|....*....|....*....
gi 294337038   148 GRTALHEACAAGHTACVHVLLVAGADPNI 176
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 118-252 1.35e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 41.15  E-value: 1.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 118 TPLHVAASRGHTEVLRLLLrrrarpDSAPG------------GRTALHEACAAGHTACVHVLLVAGADPNIADQDGkrpL 185
Cdd:cd22192   53 TALHVAALYDNLEAAVVLM------EAAPElvnepmtsdlyqGETALHIAVVNQNLNLVRELIARGADVVSPRATG---T 123

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 294337038 186 HLCRGPGTLecaellLRFGarvdgrseeeeETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPL 252
Cdd:cd22192  124 FFRPGPKNL------IYYG-----------EHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVL 173
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 383-401 2.01e-03

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 35.88  E-value: 2.01e-03
                         10
                 ....*....|....*....
gi 294337038 383 QPRSLQHLSRCALRSHLEG 401
Cdd:cd03723    2 TPRSLQHLCRCAIRKLLGS 20
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 383-399 6.53e-03

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 34.45  E-value: 6.53e-03
                          10
                  ....*....|....*..
gi 294337038  383 QPRSLQHLSRCALRSHL 399
Cdd:pfam07525   1 TPRSLQHLCRLAIRRAL 17
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
114-358 5.54e-35

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 131.23  E-value: 5.54e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 114 EELTTPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPG 192
Cdd:COG0666   52 ALGALLLLAAALAGDLLVALLLLAAGADINaKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNG 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 193 TLECAELLLRFGARVDGRSEEEEeTPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLlaacdvrcqsitdaeattar 272
Cdd:COG0666  132 NLEIVKLLLEAGADVNAQDNDGN-TPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPL-------------------- 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 273 clqlcslllsagadadaadqdkqrplHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHcalqgpaAALAQSPEHVVRA 352
Cdd:COG0666  191 --------------------------HLAAENGHLEIVKLLLEAGADVNAKDNDGKTALD-------LAAENGNLEIVKL 237


                 ....*.
gi 294337038 353 LLNHGA 358
Cdd:COG0666  238 LLEAGA 243
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
97-358 2.32e-29

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 115.82  E-value: 2.32e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038  97 DFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPN 175
Cdd:COG0666    2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADaLGALLLLAAALAGDLLVALLLLAAGADIN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 176 IADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEeTPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLlaa 255
Cdd:COG0666   82 AKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGE-TPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPL--- 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 256 cdvrcqsitdaeattarclqlcslllsagadadaadqdkqrplHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHcal 335
Cdd:COG0666  158 -------------------------------------------HLAAANGNLEIVKLLLEAGADVNARDNDGETPLH--- 191

                        250       260
                 ....*....|....*....|...
gi 294337038 336 qgpAAALAQSPEhVVRALLNHGA 358
Cdd:COG0666  192 ---LAAENGHLE-IVKLLLEAGA 210
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
118-256 1.76e-26

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 108.12  E-value: 1.76e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 118 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLEC 196
Cdd:COG0666  122 TPLHLAAYNGNLEIVKLLLEAGADVNAQdNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEI 201

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 197 AELLLRFGARVDGRSeEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAAC 256
Cdd:COG0666  202 VKLLLEAGADVNAKD-NDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAA 260
Ank_2 pfam12796
Ankyrin repeats (3 copies);
152-245 7.74e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 83.63  E-value: 7.74e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038  152 LHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFgarVDGRSEEEEETPLHVAARLGHVELA 231
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH---ADVNLKDNGRTALHYAARSGHLEIV 77

                          90
                  ....*....|....
gi 294337038  232 DLLLRRGACPDARN 245
Cdd:pfam12796  78 KLLLEKGADINVKD 91
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
117-252 2.09e-19

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 88.09  E-value: 2.09e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 117 TTPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLE 195
Cdd:COG0666  154 NTPLHLAAANGNLEIVKLLLEAGADVNARdNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLE 233

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 294337038 196 CAELLLRFGARVDGRsEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPL 252
Cdd:COG0666  234 IVKLLLEAGADLNAK-DKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
Ank_2 pfam12796
Ankyrin repeats (3 copies);
219-358 2.92e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 59.36  E-value: 2.92e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038  219 LHVAARLGHVELADLLLRRGACPDARNAEGWTpllaacdvrcqsitdaeattarclqlcslllsagadadaadqdkqrPL 298
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRT----------------------------------------------AL 34

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038  299 HLACRRGHAAVVELLLSCGVSANTMDygGHTPLHCalqgpaAALAQSPEhVVRALLNHGA 358
Cdd:pfam12796  35 HLAAKNGHLEIVKLLLEHADVNLKDN--GRTALHY------AARSGHLE-IVKLLLEKGA 85
PHA03095 PHA03095
ankyrin-like protein; Provisional
 148-334 4.33e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 64.66  E-value: 4.33e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 148 GRTALHeacAAGHTAC------VHVLLVAGADPNIADQDGKRPLHLC-RGPGTLECAELLLRFGARVDGRSeEEEETPLH 220
Cdd:PHA03095  47 GKTPLH---LYLHYSSekvkdiVRLLLEAGADVNAPERCGFTPLHLYlYNATTLDVIKLLIKAGADVNAKD-KVGRTPLH 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 221 VAARlG---HVELADLLLRRGACPDARNAEGWTPL-----------------------LAACDVRCQSITDAEATTARCL 274
Cdd:PHA03095 123 VYLS-GfniNPKVIRLLLRKGADVNALDLYGMTPLavllksrnanvellrllidagadVYAVDDRFRSLLHHHLQSFKPR 201

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 294337038 275 QL-CSLLLSAGADADAADQDKQRPLHLA-----CRRGhaaVVELLLSCGVSANTMDYGGHTPLHCA 334
Cdd:PHA03095 202 ARiVRELIRAGCDPAATDMLGNTPLHSMatgssCKRS---LVLPLLIAGISINARNRYGQTPLHYA 264
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 152-240 1.98e-10

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 62.61  E-value: 1.98e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 152 LHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDgRSEEEEETPLHVAARLGHVELA 231
Cdd:PTZ00322  86 LCQLAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPT-LLDKDGKTPLELAEENGFREVV 164


                 ....*....
gi 294337038 232 DLLLRRGAC 240
Cdd:PTZ00322 165 QLLSRHSQC 173
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 148-223 8.73e-10

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 60.68  E-value: 8.73e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 148 GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLR-------FGAR-----VDGRSEEEE 215
Cdd:PTZ00322 115 GRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRhsqchfeLGANakpdsFTGKPPSLE 194


                 ....*...
gi 294337038 216 ETPLHVAA 223
Cdd:PTZ00322 195 DSPISSHH 202
Ank_2 pfam12796
Ankyrin repeats (3 copies);
118-178 1.37e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 54.74  E-value: 1.37e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 294337038  118 TPLHVAASRGHTEVLRLLLRRrARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIAD 178
Cdd:pfam12796  32 TALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
298-361 1.57e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 54.74  E-value: 1.57e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 294337038  298 LHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHcalqgpAAALAQSPEhVVRALLNHGAVRV 361
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALH------LAAKNGHLE-IVKLLLEHADVNL 57
PHA03095 PHA03095
ankyrin-like protein; Provisional
 167-358 3.21e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 58.50  E-value: 3.21e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 167 LLVAGADPNIADQDGKRPLHLCRGPGTLECAE---LLLRFGARVDGRsEEEEETPLHVAARLGHVE-LADLLLRRGACPD 242
Cdd:PHA03095  33 LLAAGADVNFRGEYGKTPLHLYLHYSSEKVKDivrLLLEAGADVNAP-ERCGFTPLHLYLYNATTLdVIKLLIKAGADVN 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 243 ARNAEGWTPLLAacdvrcqsitdaeattarclqlcslllsagadadaadqdkqrplHLACRRGHAAVVELLLSCGVSANT 322
Cdd:PHA03095 112 AKDKVGRTPLHV--------------------------------------------YLSGFNINPKVIRLLLRKGADVNA 147

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 294337038 323 MDYGGHTPLHCALQGPAAALAqspehVVRALLNHGA 358
Cdd:PHA03095 148 LDLYGMTPLAVLLKSRNANVE-----LLRLLIDAGA 178
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 164-358 5.69e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 54.58  E-value: 5.69e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 164 VHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRsEEEEETPLHVAARLGHVELADLLLRRGACPDA 243
Cdd:PHA02874 107 IKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIE-DDNGCYPIHIAIKHNFFDIIKLLLEKGAYANV 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 244 RNAEGWTPLLAAC---DVRCQS--ITDAEATTARCLQLCSlllsagadadaadqdkqrPLHLACRRGHAaVVELLLScGV 318
Cdd:PHA02874 186 KDNNGESPLHNAAeygDYACIKllIDHGNHIMNKCKNGFT------------------PLHNAIIHNRS-AIELLIN-NA 245

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 294337038 319 SANTMDYGGHTPLHCALQGPAAalaqspEHVVRALLNHGA 358
Cdd:PHA02874 246 SINDQDIDGSTPLHHAINPPCD------IDIIDILLYHKA 279
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 164-358 8.61e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 53.84  E-value: 8.61e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 164 VHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDA 243
Cdd:PHA02875  51 IKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDI 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 244 RNAEGWTPLLAAC---DVR----------CQSITDAEATTarclqlcslllsagadadaadqdkqrPLHLACRRGHAAVV 310
Cdd:PHA02875 131 PNTDKFSPLHLAVmmgDIKgiellidhkaCLDIEDCCGCT--------------------------PLIIAMAKGDIAIC 184

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 294337038 311 ELLLSCGVSANTMDYGGHTPLHCalqgpaAALAQSPEHVVRALLNHGA 358
Cdd:PHA02875 185 KMLLDSGANIDYFGKNGCVAALC------YAIENNKIDIVRLFIKRGA 226
Ank_5 pfam13857
Ankyrin repeats (many copies);
200-252 4.12e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 46.57  E-value: 4.12e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 294337038  200 LLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPL 252
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 161-335 1.21e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 50.65  E-value: 1.21e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 161 TACVHVLLVAGADPNIADQD-GKRPLHLCRGPGTLECAELLLRFGARVDgRSEEEEETPLHVAARLGHVELADLLLRRGA 239
Cdd:PHA02878 147 AEITKLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVN-IPDKTNNSPLHHAVKHYNKPIVHILLENGA 225

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 240 CPDARNAEGWTPLLAACDvRCQSITDAEATTARCLQLCSLLLSAGADadaadqdkqrPLHLACRrgHAAVVELLLSCGVS 319
Cdd:PHA02878 226 STDARDKCGNTPLHISVG-YCKDYDILKLLLEHGVDVNAKSYILGLT----------ALHSSIK--SERKLKLLLEYGAD 292

                        170
                 ....*....|....*.
gi 294337038 320 ANTMDYGGHTPLHCAL 335
Cdd:PHA02878 293 INSLNSYKLTPLSSAV 308
Ank_4 pfam13637
Ankyrin repeats (many copies);
217-256 2.08e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 44.57  E-value: 2.08e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 294337038  217 TPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAAC 256
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAA 42
Ank_4 pfam13637
Ankyrin repeats (many copies);
148-201 4.70e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 43.42  E-value: 4.70e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 294337038  148 GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLL 201
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 118-245 5.01e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 48.71  E-value: 5.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 118 TPLHVAASRGHTE---VLRLLLRRRARPDSapGGRTALHEACAAGHTACVHVL--LVAGADPNIADQdgkrplHLCRGP- 191
Cdd:PLN03192 560 TPLHIAASKGYEDcvlVLLKHACNVHIRDA--NGNTALWNAISAKHHKIFRILyhFASISDPHAAGD------LLCTAAk 631

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 294337038 192 -GTLECAELLLRFGARVDGRsEEEEETPLHVAARLGHVELADLLLRRGACPDARN 245
Cdd:PLN03192 632 rNDLTAMKELLKQGLNVDSE-DHQGATALQVAMAEDHVDMVRLLIMNGADVDKAN 685
PHA03095 PHA03095
ankyrin-like protein; Provisional
 148-260 5.42e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 48.48  E-value: 5.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 148 GRTALHEACAAGHT--ACVHVLLVAGADPNIADQDGKRPLHLCRGPGTleCAELLLRF----GARVDGRSEEEEeTPLHV 221
Cdd:PHA03095 187 FRSLLHHHLQSFKPraRIVRELIRAGCDPAATDMLGNTPLHSMATGSS--CKRSLVLPlliaGISINARNRYGQ-TPLHY 263

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 294337038 222 AARLGHVELADLLLRRGACPDARNAEGWTPLLAA---CDVRC 260
Cdd:PHA03095 264 AAVFNNPRACRRLIALGADINAVSSDGNTPLSLMvrnNNGRA 305
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 148-178 1.47e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 41.51  E-value: 1.47e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 294337038  148 GRTALHEACA-AGHTACVHVLLVAGADPNIAD 178
Cdd:pfam00023   2 GNTPLHLAAGrRGNLEIVKLLLSKGADVNARD 33
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 216-245 2.18e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 41.12  E-value: 2.18e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 294337038  216 ETPLHVAA-RLGHVELADLLLRRGACPDARN 245
Cdd:pfam00023   3 NTPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
Ank_4 pfam13637
Ankyrin repeats (many copies);
117-168 2.35e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 41.49  E-value: 2.35e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 294337038  117 TTPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLL 168
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGnGETALHFAASNGNVEVLKLLL 54
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 149-358 4.25e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 45.37  E-value: 4.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 149 RTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDgRSEEEEETPLHVAARLGHV 228
Cdd:PHA02875   3 QVALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPD-VKYPDIESELHDAVEEGDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 229 ELADLLLRRGA-CPDARNAEGWTPLLAacdvrcqsitdaeATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHA 307
Cdd:PHA02875  82 KAVEELLDLGKfADDVFYKDGMTPLHL-------------ATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDI 148

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 294337038 308 AVVELLLSCGVSANTMDYGGHTPLhcalqgpAAALAQSPEHVVRALLNHGA 358
Cdd:PHA02875 149 KGIELLIDHKACLDIEDCCGCTPL-------IIAMAKGDIAICKMLLDSGA 192
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 148-176 6.17e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.88  E-value: 6.17e-05
                           10        20
                   ....*....|....*....|....*....
gi 294337038   148 GRTALHEACAAGHTACVHVLLVAGADPNI 176
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 164-324 9.15e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 44.66  E-value: 9.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 164 VHVLLVAGADPNIADQDGKRPLHLC--RGPGTLECAELLLRFGARVDGRSEEEEeTPLHVAARLGHVEL----------- 230
Cdd:PHA03100  89 VKLLLEYGANVNAPDNNGITPLLYAisKKSNSYSIVEYLLDNGANVNIKNSDGE-NLLHLYLESNKIDLkilkllidkgv 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 231 -------ADLLLRRGACPDARNAEGWTPLLAACD----------VRCQS----ITDAEATtarclqlcslllsagadada 289
Cdd:PHA03100 168 dinaknrVNYLLSYGVPINIKDVYGFTPLHYAVYnnnpefvkylLDLGAnpnlVNKYGDT-------------------- 227

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 294337038 290 adqdkqrPLHLACRRGHAAVVELLLSCGVSANTMD 324
Cdd:PHA03100 228 -------PLHIAILNNNKEIFKLLLNNGPSIKTII 255
PHA02946 PHA02946
ankyin-like protein; Provisional
 148-219 1.03e-04

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 44.27  E-value: 1.03e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 294337038 148 GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPG--TLECAELLLRFGARVDGRSEEEEETPL 219
Cdd:PHA02946  72 GNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDdeVIERINLLVQYGAKINNSVDEEGCGPL 145
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 148-358 1.29e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 44.28  E-value: 1.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 148 GRTALHEACAAGH-TACVHVLLVAGADPNIADQDGKRPLH----LCRGPGTLECaelLLRFGARVDGRsEEEEETPLHVA 222
Cdd:PHA02876 307 GETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYITPLHqastLDRNKDIVIT---LLELGANVNAR-DYCDKTPIHYA 382

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 223 ARLGHVELADLLLRRGACPDARNAEGWTPL-LAACD----VRCQSITDAEATTARCLQLCSLllsagadadaadqdkqrP 297
Cdd:PHA02876 383 AVRNNVVIINTLLDYGADIEALSQKIGTALhFALCGtnpyMSVKTLIDRGANVNSKNKDLST-----------------P 445

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 294337038 298 LHLACRRG-HAAVVELLLSCGVSANTMDYGGHTPLHCALQgpaaalaqsPEHVVRALLNHGA 358
Cdd:PHA02876 446 LHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPLLIALE---------YHGIVNILLHYGA 498
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 195-358 1.42e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 44.10  E-value: 1.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 195 ECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNaegwtpllaacdvrcqsITDaeattarcl 274
Cdd:PHA02878 148 EITKLLLSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPD-----------------KTN--------- 201

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 275 qlcslllsagadadaadqdkQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALqgpAAALAQSpehVVRALL 354
Cdd:PHA02878 202 --------------------NSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISV---GYCKDYD---ILKLLL 255


                 ....
gi 294337038 355 NHGA 358
Cdd:PHA02878 256 EHGV 259
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 118-239 2.14e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 43.44  E-value: 2.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 118 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTA-LHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLEC 196
Cdd:PHA02875 104 TPLHLATILKKLDIMKLLIARGADPDIPNTDKFSpLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAI 183

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 294337038 197 AELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGA 239
Cdd:PHA02875 184 CKMLLDSGANIDYFGKNGCVAALCYAIENNKIDIVRLFIKRGA 226
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 155-358 4.04e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 42.93  E-value: 4.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 155 ACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRsEEEEETPLHVAARLGHVELADLL 234
Cdd:PLN03192 532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIR-DANGNTALWNAISAKHHKIFRIL 610

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 235 LRRGACPDARnaegwtpllAACDVRCqsitdaeattarclqlcslllsagadadaadqdkqrplhLACRRGHAAVVELLL 314
Cdd:PLN03192 611 YHFASISDPH---------AAGDLLC---------------------------------------TAAKRNDLTAMKELL 642

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 294337038 315 SCGVSANTMDYGGHTplhcALQgpaAALAQSPEHVVRALLNHGA 358
Cdd:PLN03192 643 KQGLNVDSEDHQGAT----ALQ---VAMAEDHVDMVRLLIMNGA 679
Ank_4 pfam13637
Ankyrin repeats (many copies);
296-337 4.82e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 38.02  E-value: 4.82e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 294337038  296 RPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQG 337
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASN 44
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 148-301 4.96e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 42.17  E-value: 4.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 148 GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEeTPLHVA-ARLG 226
Cdd:PHA02878 168 GNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGN-TPLHISvGYCK 246

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 294337038 227 HVELADLLLRRGACPDARNA-EGWTPLLAacdvrcqSITDAEATTarclqlcsLLLSAGADADAADQDKQRPLHLA 301
Cdd:PHA02878 247 DYDILKLLLEHGVDVNAKSYiLGLTALHS-------SIKSERKLK--------LLLEYGADINSLNSYKLTPLSSA 307
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 295-334 7.95e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 41.81  E-value: 7.95e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 294337038 295 QRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 334
Cdd:PTZ00322 116 RTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELA 155
PHA02736 PHA02736
Viral ankyrin protein; Provisional
 178-257 8.28e-04

Viral ankyrin protein; Provisional


Pssm-ID: 165103 [Multi-domain]  Cd Length: 154  Bit Score: 39.86  E-value: 8.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 178 DQDGKRPLHLCRGPGTLECAE---LLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRR-GACPDARNAEGWTPLL 253
Cdd:PHA02736  52 NRHGKQCVHIVSNPDKADPQEklkLLMEWGADINGKERVFGNTPLHIAVYTQNYELATWLCNQpGVNMEILNYAFKTPYY 131


                 ....
gi 294337038 254 AACD 257
Cdd:PHA02736 132 VACE 135
PHA02946 PHA02946
ankyin-like protein; Provisional
 164-332 8.35e-04

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 41.58  E-value: 8.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 164 VHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGrSEEEEETPLHVAARLGH--VELADLLLRRGA-C 240
Cdd:PHA02946  55 VEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNA-CDKQHKTPLYYLSGTDDevIERINLLVQYGAkI 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 241 PDARNAEGWTPLLAAcdvrcqsiTDAEATTARCLQLCSLLLSAGADADAADQDKqrplHLACRRGHAAVVELLLSCGVSA 320
Cdd:PHA02946 134 NNSVDEEGCGPLLAC--------TDPSERVFKKIMSIGFEARIVDKFGKNHIHR----HLMSDNPKASTISWMMKLGISP 201

                        170
                 ....*....|..
gi 294337038 321 NTMDYGGHTPLH 332
Cdd:PHA02946 202 SKPDHDGNTPLH 213
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 297-321 8.91e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.41  E-value: 8.91e-04
                           10        20
                   ....*....|....*....|....*
gi 294337038   297 PLHLACRRGHAAVVELLLSCGVSAN 321
Cdd:smart00248   5 PLHLAAENGNLEVVKLLLDKGADIN 29
Ank_5 pfam13857
Ankyrin repeats (many copies);
294-334 9.04e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 37.33  E-value: 9.04e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 294337038  294 KQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 334
Cdd:pfam13857  16 GYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 198-358 9.24e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 41.19  E-value: 9.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 198 ELLLRFGARVDGrSEEEEETPLHVAARLGHV-----ELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTAR 272
Cdd:PHA03100  52 KILLDNGADINS-STKNNSTPLHYLSNIKYNltdvkEIVKLLLEYGANVNAPDNNGITPLLYAISKKSNSYSIVEYLLDN 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 273 CLQLCSLLLSAGAdadaadqdkqrPLHLACRRGH------------------AAVVELLLSCGVSANTMDYGGHTPLHca 334
Cdd:PHA03100 131 GANVNIKNSDGEN-----------LLHLYLESNKidlkilkllidkgvdinaKNRVNYLLSYGVPINIKDVYGFTPLH-- 197

                        170       180
                 ....*....|....*....|....
gi 294337038 335 lqgpAAALAQSPEhVVRALLNHGA 358
Cdd:PHA03100 198 ----YAVYNNNPE-FVKYLLDLGA 216
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 217-243 1.02e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.41  E-value: 1.02e-03
                           10        20
                   ....*....|....*....|....*..
gi 294337038   217 TPLHVAARLGHVELADLLLRRGACPDA 243
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADINA 30
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 118-252 1.35e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 41.15  E-value: 1.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 118 TPLHVAASRGHTEVLRLLLrrrarpDSAPG------------GRTALHEACAAGHTACVHVLLVAGADPNIADQDGkrpL 185
Cdd:cd22192   53 TALHVAALYDNLEAAVVLM------EAAPElvnepmtsdlyqGETALHIAVVNQNLNLVRELIARGADVVSPRATG---T 123

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 294337038 186 HLCRGPGTLecaellLRFGarvdgrseeeeETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPL 252
Cdd:cd22192  124 FFRPGPKNL------IYYG-----------EHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVL 173
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 216-239 1.39e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.08  E-value: 1.39e-03
                          10        20
                  ....*....|....*....|....
gi 294337038  216 ETPLHVAARLGHVELADLLLRRGA 239
Cdd:pfam13606   3 NTPLHLAARNGRLEIVKLLLENGA 26
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 149-358 1.70e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 40.82  E-value: 1.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 149 RTALHEACAAGHTACVHVLLVAGADPNIADQDG---------------------------KRPLHLCRGPGT--LECAEL 199
Cdd:PHA02876 179 ITPIHYAAERGNAKMVNLLLSYGADVNIIALDDlsvlecavdsknidtikaiidnrsninKNDLSLLKAIRNedLETSLL 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 200 LLRFGARVDGrSEEEEETPLHVAARLGHV-ELADLLLRRGACPDARNAEGWTPL----------------------LAAC 256
Cdd:PHA02876 259 LYDAGFSVNS-IDDCKNTPLHHASQAPSLsRLVPKLLERGADVNAKNIKGETPLylmakngydtenirtlimlgadVNAA 337

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 257 DVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQ 336
Cdd:PHA02876 338 DRLYITPLHQASTLDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALC 417

                        250       260
                 ....*....|....*....|..
gi 294337038 337 GpaaalaQSPEHVVRALLNHGA 358
Cdd:PHA02876 418 G------TNPYMSVKTLIDRGA 433
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 148-176 1.90e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 35.70  E-value: 1.90e-03
                          10        20
                  ....*....|....*....|....*....
gi 294337038  148 GRTALHEACAAGHTACVHVLLVAGADPNI 176
Cdd:pfam13606   2 GNTPLHLAARNGRLEIVKLLLENGADINA 30
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 383-401 2.01e-03

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 35.88  E-value: 2.01e-03
                         10
                 ....*....|....*....
gi 294337038 383 QPRSLQHLSRCALRSHLEG 401
Cdd:cd03723    2 TPRSLQHLCRCAIRKLLGS 20
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 297-322 2.10e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 35.31  E-value: 2.10e-03
                          10        20
                  ....*....|....*....|....*.
gi 294337038  297 PLHLACRRGHAAVVELLLSCGVSANT 322
Cdd:pfam13606   5 PLHLAARNGRLEIVKLLLENGADINA 30
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 297-324 4.02e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 34.96  E-value: 4.02e-03
                          10        20
                  ....*....|....*....|....*....
gi 294337038  297 PLHLAC-RRGHAAVVELLLSCGVSANTMD 324
Cdd:pfam00023   5 PLHLAAgRRGNLEIVKLLLSKGADVNARD 33
Ank_5 pfam13857
Ankyrin repeats (many copies);
147-188 4.64e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 35.40  E-value: 4.64e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 294337038  147 GGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLC 188
Cdd:pfam13857  15 EGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 152-358 4.87e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 39.09  E-value: 4.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 152 LHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHL-CRGPGTLECAELLlrfgARVDGRSEEEEETPLHVAARLGHVEL 230
Cdd:PHA02878  41 LHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIiCKEPNKLGMKEMI----RSINKCSVFYTLVAIKDAFNNRNVEI 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294337038 231 ADLLLRrgacpDARNAEGWTPLLAACDVRCQSITDAEATtarclqlCSLLLSAGADADAADQDKQRPLHLACRRGHAAVV 310
Cdd:PHA02878 117 FKIILT-----NRYKNIQTIDLVYIDKKSKDDIIEAEIT-------KLLLSYGADINMKDRHKGNTALHYATENKDQRLT 184

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 294337038 311 ELLLSCGVSANTMDYGGHTPLHcalqgpaAALAQSPEHVVRALLNHGA 358
Cdd:PHA02878 185 ELLLSYGANVNIPDKTNNSPLH-------HAVKHYNKPIVHILLENGA 225
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 383-399 6.53e-03

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 34.45  E-value: 6.53e-03
                          10
                  ....*....|....*..
gi 294337038  383 QPRSLQHLSRCALRSHL 399
Cdd:pfam07525   1 TPRSLQHLCRLAIRRAL 17
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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