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Conserved domains on  [gi|217272844|ref|NP_001136065|]
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inositol-tetrakisphosphate 1-kinase isoform a [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ins134_P3_kin pfam05770
Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain; This family consists of several ...
119-318 5.61e-114

Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain; This family consists of several inositol 1, 3, 4-trisphosphate 5/6-kinase proteins. Inositol 1,3,4-trisphosphate is at a branch point in inositol phosphate metabolism. It is dephosphorylated by specific phosphatases to either inositol 3,4-bisphosphate or inositol 1,3-bisphosphate. Alternatively, it is phosphorylated to inositol 1,3,4,6-tetrakisphosphate or inositol 1,3,4,5-tetrakisphosphate by inositol trisphosphate 5/6-kinase. This entry represents the ATP-grasp domain.


:

Pssm-ID: 368606  Cd Length: 201  Bit Score: 331.73  E-value: 5.61e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217272844  119 YMEDDRICSPPFMELTSLcGDDTMRLLEKNGLTFPFICKTRVAHGT-NSHEMAIVFNQEGLNAIQPPCVVQNFINHNAVL 197
Cdd:pfam05770   1 SMEDGRFGVPPQVVVMKD-ASSLSRAGAKAGLTFPLIAKPLVADGTaKSHEMSLVYDQEGLNKLQPPLVLQEFVNHGGVL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217272844  198 YKVFVVGESYTVVQRPSLKNFSAGTSDRESIFFNSHNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSL 277
Cdd:pfam05770  80 FKVYVVGEHVTVVKRRSLPDVSAGTLDRSSGSFRFSQVSNLTASADDAELDKILEIAEMPPDPFLEDLARALRRALGLRL 159
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 217272844  278 FGIDIIINNQT-GQHAVIDINAFPGYEGVSEFFTDLLNHIAT 318
Cdd:pfam05770 160 FNFDIIRDAGTaDRYLVIDINYFPGYAKMPEYETVLTDFFWS 201
Ins134_P3_kin_N pfam17927
Inositol 1,3,4-trisphosphate 5/6-kinase pre-ATP-grasp domain; This family consists of several ...
9-100 2.51e-42

Inositol 1,3,4-trisphosphate 5/6-kinase pre-ATP-grasp domain; This family consists of several inositol 1, 3, 4-trisphosphate 5/6-kinase proteins. Inositol 1,3,4-trisphosphate is at a branch point in inositol phosphate metabolism. It is dephosphorylated by specific phosphatases to either inositol 3,4-bisphosphate or inositol 1,3-bisphosphate. Alternatively, it is phosphorylated to inositol 1,3,4,6-tetrakisphosphate or inositol 1,3,4,5-tetrakisphosphate by inositol trisphosphate 5/6-kinase. This entry represents the N-terminal pre-ATP-grasp domain.


:

Pssm-ID: 407776  Cd Length: 80  Bit Score: 143.39  E-value: 2.51e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217272844    9 RVGYWLSEKKIKKLNFQAFAELCRKRGMEVVQLNLSRPIEEQGPLDVIIHKLTDVileadqndsqslELVHRFQEYIDAH 88
Cdd:pfam17927   1 LVGYALAEKKIKSFIQPSLAELARKRGIDLVQLDPSRPLSEQGPFDIIIHKLTDK------------EWRHRLEEFREAH 68
                          90
                  ....*....|..
gi 217272844   89 PETIVLDPLPAI 100
Cdd:pfam17927  69 PEVPVLDPPPAI 80
 
Name Accession Description Interval E-value
Ins134_P3_kin pfam05770
Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain; This family consists of several ...
119-318 5.61e-114

Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain; This family consists of several inositol 1, 3, 4-trisphosphate 5/6-kinase proteins. Inositol 1,3,4-trisphosphate is at a branch point in inositol phosphate metabolism. It is dephosphorylated by specific phosphatases to either inositol 3,4-bisphosphate or inositol 1,3-bisphosphate. Alternatively, it is phosphorylated to inositol 1,3,4,6-tetrakisphosphate or inositol 1,3,4,5-tetrakisphosphate by inositol trisphosphate 5/6-kinase. This entry represents the ATP-grasp domain.


Pssm-ID: 368606  Cd Length: 201  Bit Score: 331.73  E-value: 5.61e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217272844  119 YMEDDRICSPPFMELTSLcGDDTMRLLEKNGLTFPFICKTRVAHGT-NSHEMAIVFNQEGLNAIQPPCVVQNFINHNAVL 197
Cdd:pfam05770   1 SMEDGRFGVPPQVVVMKD-ASSLSRAGAKAGLTFPLIAKPLVADGTaKSHEMSLVYDQEGLNKLQPPLVLQEFVNHGGVL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217272844  198 YKVFVVGESYTVVQRPSLKNFSAGTSDRESIFFNSHNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSL 277
Cdd:pfam05770  80 FKVYVVGEHVTVVKRRSLPDVSAGTLDRSSGSFRFSQVSNLTASADDAELDKILEIAEMPPDPFLEDLARALRRALGLRL 159
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 217272844  278 FGIDIIINNQT-GQHAVIDINAFPGYEGVSEFFTDLLNHIAT 318
Cdd:pfam05770 160 FNFDIIRDAGTaDRYLVIDINYFPGYAKMPEYETVLTDFFWS 201
PLN02941 PLN02941
inositol-tetrakisphosphate 1-kinase
9-313 6.85e-69

inositol-tetrakisphosphate 1-kinase


Pssm-ID: 215508 [Multi-domain]  Cd Length: 328  Bit Score: 220.98  E-value: 6.85e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217272844   9 RVGYWLSEKKIKKLNFQAFAELCRKRGMEVVQLNLSRPIEEQGPLDVIIHKLTDvileadQNDSQSLElvhrfqEYIDAH 88
Cdd:PLN02941  23 VVGYALTPKKVKSFLQPSLEALARSKGIDLVAIDPSRPLSEQGPFDVILHKLYG------KEWRQQLE------EYREKH 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217272844  89 PETIVLDPLPAIRTLLDRSKSYELIRKIEAYMEDDRICSPPFMeltsLCGDDTMRLLE---KNGLTFPFICKTRVAHGT- 164
Cdd:PLN02941  91 PDVTVLDPPDAIQRLHNRQSMLQVVADLKLSDGYGSVGVPKQL----VVYDDESSIPDavaLAGLKFPLVAKPLVADGSa 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217272844 165 NSHEMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAG-TSDRESIFFNShNVSKPESSSV 243
Cdd:PLN02941 167 KSHKMSLAYDQEGLSKLEPPLVLQEFVNHGGVLFKVYVVGDYVKCVRRFSLPDVSEEeLSSAEGVLPFP-RVSNAAASAD 245
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 217272844 244 LTELDKIEG-VFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQH-AVIDINAFPGYEGVSEF---FTDLL 313
Cdd:PLN02941 246 DADNGGLDPeVAELPPRPFLEDLARELRRRLGLRLFNFDMIREHGTGDRyYVIDINYFPGYAKMPGYetvLTDFL 320
Ins134_P3_kin_N pfam17927
Inositol 1,3,4-trisphosphate 5/6-kinase pre-ATP-grasp domain; This family consists of several ...
9-100 2.51e-42

Inositol 1,3,4-trisphosphate 5/6-kinase pre-ATP-grasp domain; This family consists of several inositol 1, 3, 4-trisphosphate 5/6-kinase proteins. Inositol 1,3,4-trisphosphate is at a branch point in inositol phosphate metabolism. It is dephosphorylated by specific phosphatases to either inositol 3,4-bisphosphate or inositol 1,3-bisphosphate. Alternatively, it is phosphorylated to inositol 1,3,4,6-tetrakisphosphate or inositol 1,3,4,5-tetrakisphosphate by inositol trisphosphate 5/6-kinase. This entry represents the N-terminal pre-ATP-grasp domain.


Pssm-ID: 407776  Cd Length: 80  Bit Score: 143.39  E-value: 2.51e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217272844    9 RVGYWLSEKKIKKLNFQAFAELCRKRGMEVVQLNLSRPIEEQGPLDVIIHKLTDVileadqndsqslELVHRFQEYIDAH 88
Cdd:pfam17927   1 LVGYALAEKKIKSFIQPSLAELARKRGIDLVQLDPSRPLSEQGPFDIIIHKLTDK------------EWRHRLEEFREAH 68
                          90
                  ....*....|..
gi 217272844   89 PETIVLDPLPAI 100
Cdd:pfam17927  69 PEVPVLDPPPAI 80
LysX COG0189
Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily [Amino acid transport ...
24-305 5.46e-10

Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily [Amino acid transport and metabolism, Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis, Secondary metabolites biosynthesis, transport and catabolism]; Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 439959 [Multi-domain]  Cd Length: 289  Bit Score: 59.95  E-value: 5.46e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217272844  24 FQAFAELCRKRGMEVVQLNLSRPIEEQGPLDVIIHKLT----DVIL-EADQnDSQSLELVHRFQEyidahPETIVLDPLP 98
Cdd:COG0189   16 TKALIEAAQRRGHEVEVIDPDDLTLDLGRAPELYRGEDlsefDAVLpRIDP-PFYGLALLRQLEA-----AGVPVVNDPE 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217272844  99 AIRTLLDRSKSYELirkieayMEDDRICSPPfmelTSLCGD--DTMRLLEKNGltFPFICKTrvAHGTNSHEMAIVFNQE 176
Cdd:COG0189   90 AIRRARDKLFTLQL-------LARAGIPVPP----TLVTRDpdDLRAFLEELG--GPVVLKP--LDGSGGRGVFLVEDED 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217272844 177 GLNAI--------QPPCVVQNFINHNAVLYK-VFVV-GESYTVVQRpslknFSAGTSDResiffnsHNVSKpesssvlte 246
Cdd:COG0189  155 ALESIlealtelgSEPVLVQEFIPEEDGRDIrVLVVgGEPVAAIRR-----IPAEGEFR-------TNLAR--------- 213
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 217272844 247 ldkiEGVFER--PSDEViRELSRALRQALGVSLFGIDIIINNqtGQHAVIDINAFPGYEGV 305
Cdd:COG0189  214 ----GGRAEPveLTDEE-RELALRAAPALGLDFAGVDLIEDD--DGPLVLEVNVTPGFRGL 267
 
Name Accession Description Interval E-value
Ins134_P3_kin pfam05770
Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain; This family consists of several ...
119-318 5.61e-114

Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain; This family consists of several inositol 1, 3, 4-trisphosphate 5/6-kinase proteins. Inositol 1,3,4-trisphosphate is at a branch point in inositol phosphate metabolism. It is dephosphorylated by specific phosphatases to either inositol 3,4-bisphosphate or inositol 1,3-bisphosphate. Alternatively, it is phosphorylated to inositol 1,3,4,6-tetrakisphosphate or inositol 1,3,4,5-tetrakisphosphate by inositol trisphosphate 5/6-kinase. This entry represents the ATP-grasp domain.


Pssm-ID: 368606  Cd Length: 201  Bit Score: 331.73  E-value: 5.61e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217272844  119 YMEDDRICSPPFMELTSLcGDDTMRLLEKNGLTFPFICKTRVAHGT-NSHEMAIVFNQEGLNAIQPPCVVQNFINHNAVL 197
Cdd:pfam05770   1 SMEDGRFGVPPQVVVMKD-ASSLSRAGAKAGLTFPLIAKPLVADGTaKSHEMSLVYDQEGLNKLQPPLVLQEFVNHGGVL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217272844  198 YKVFVVGESYTVVQRPSLKNFSAGTSDRESIFFNSHNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSL 277
Cdd:pfam05770  80 FKVYVVGEHVTVVKRRSLPDVSAGTLDRSSGSFRFSQVSNLTASADDAELDKILEIAEMPPDPFLEDLARALRRALGLRL 159
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 217272844  278 FGIDIIINNQT-GQHAVIDINAFPGYEGVSEFFTDLLNHIAT 318
Cdd:pfam05770 160 FNFDIIRDAGTaDRYLVIDINYFPGYAKMPEYETVLTDFFWS 201
PLN02941 PLN02941
inositol-tetrakisphosphate 1-kinase
9-313 6.85e-69

inositol-tetrakisphosphate 1-kinase


Pssm-ID: 215508 [Multi-domain]  Cd Length: 328  Bit Score: 220.98  E-value: 6.85e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217272844   9 RVGYWLSEKKIKKLNFQAFAELCRKRGMEVVQLNLSRPIEEQGPLDVIIHKLTDvileadQNDSQSLElvhrfqEYIDAH 88
Cdd:PLN02941  23 VVGYALTPKKVKSFLQPSLEALARSKGIDLVAIDPSRPLSEQGPFDVILHKLYG------KEWRQQLE------EYREKH 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217272844  89 PETIVLDPLPAIRTLLDRSKSYELIRKIEAYMEDDRICSPPFMeltsLCGDDTMRLLE---KNGLTFPFICKTRVAHGT- 164
Cdd:PLN02941  91 PDVTVLDPPDAIQRLHNRQSMLQVVADLKLSDGYGSVGVPKQL----VVYDDESSIPDavaLAGLKFPLVAKPLVADGSa 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217272844 165 NSHEMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAG-TSDRESIFFNShNVSKPESSSV 243
Cdd:PLN02941 167 KSHKMSLAYDQEGLSKLEPPLVLQEFVNHGGVLFKVYVVGDYVKCVRRFSLPDVSEEeLSSAEGVLPFP-RVSNAAASAD 245
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 217272844 244 LTELDKIEG-VFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQH-AVIDINAFPGYEGVSEF---FTDLL 313
Cdd:PLN02941 246 DADNGGLDPeVAELPPRPFLEDLARELRRRLGLRLFNFDMIREHGTGDRyYVIDINYFPGYAKMPGYetvLTDFL 320
Ins134_P3_kin_N pfam17927
Inositol 1,3,4-trisphosphate 5/6-kinase pre-ATP-grasp domain; This family consists of several ...
9-100 2.51e-42

Inositol 1,3,4-trisphosphate 5/6-kinase pre-ATP-grasp domain; This family consists of several inositol 1, 3, 4-trisphosphate 5/6-kinase proteins. Inositol 1,3,4-trisphosphate is at a branch point in inositol phosphate metabolism. It is dephosphorylated by specific phosphatases to either inositol 3,4-bisphosphate or inositol 1,3-bisphosphate. Alternatively, it is phosphorylated to inositol 1,3,4,6-tetrakisphosphate or inositol 1,3,4,5-tetrakisphosphate by inositol trisphosphate 5/6-kinase. This entry represents the N-terminal pre-ATP-grasp domain.


Pssm-ID: 407776  Cd Length: 80  Bit Score: 143.39  E-value: 2.51e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217272844    9 RVGYWLSEKKIKKLNFQAFAELCRKRGMEVVQLNLSRPIEEQGPLDVIIHKLTDVileadqndsqslELVHRFQEYIDAH 88
Cdd:pfam17927   1 LVGYALAEKKIKSFIQPSLAELARKRGIDLVQLDPSRPLSEQGPFDIIIHKLTDK------------EWRHRLEEFREAH 68
                          90
                  ....*....|..
gi 217272844   89 PETIVLDPLPAI 100
Cdd:pfam17927  69 PEVPVLDPPPAI 80
LysX COG0189
Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily [Amino acid transport ...
24-305 5.46e-10

Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily [Amino acid transport and metabolism, Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis, Secondary metabolites biosynthesis, transport and catabolism]; Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 439959 [Multi-domain]  Cd Length: 289  Bit Score: 59.95  E-value: 5.46e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217272844  24 FQAFAELCRKRGMEVVQLNLSRPIEEQGPLDVIIHKLT----DVIL-EADQnDSQSLELVHRFQEyidahPETIVLDPLP 98
Cdd:COG0189   16 TKALIEAAQRRGHEVEVIDPDDLTLDLGRAPELYRGEDlsefDAVLpRIDP-PFYGLALLRQLEA-----AGVPVVNDPE 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217272844  99 AIRTLLDRSKSYELirkieayMEDDRICSPPfmelTSLCGD--DTMRLLEKNGltFPFICKTrvAHGTNSHEMAIVFNQE 176
Cdd:COG0189   90 AIRRARDKLFTLQL-------LARAGIPVPP----TLVTRDpdDLRAFLEELG--GPVVLKP--LDGSGGRGVFLVEDED 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217272844 177 GLNAI--------QPPCVVQNFINHNAVLYK-VFVV-GESYTVVQRpslknFSAGTSDResiffnsHNVSKpesssvlte 246
Cdd:COG0189  155 ALESIlealtelgSEPVLVQEFIPEEDGRDIrVLVVgGEPVAAIRR-----IPAEGEFR-------TNLAR--------- 213
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 217272844 247 ldkiEGVFER--PSDEViRELSRALRQALGVSLFGIDIIINNqtGQHAVIDINAFPGYEGV 305
Cdd:COG0189  214 ----GGRAEPveLTDEE-RELALRAAPALGLDFAGVDLIEDD--DGPLVLEVNVTPGFRGL 267
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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