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Conserved domains on  [gi|218083730|ref|NP_001136156|]
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zinc finger MYM-type protein 5 isoform 3 [Homo sapiens]

Protein Classification

zinc finger and BTB domain-containing protein( domain architecture ID 12219290)

zinc finger and BTB (BR-C, ttk and bab)/POZ (Pox virus and Zinc finger) domain-containing protein similar to Drosophila melanogaster fruitless (fru), which plays a key role in the formation of neural circuits underlying Drosophila male courtship behavior

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 375-415 1.41e-07

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


:

Pssm-ID: 428958  Cd Length: 40  Bit Score: 48.14  E-value: 1.41e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 218083730  375 LIMNCCEHCGEYMPSKSTGNnILVIGGQQKRFCCQSCINEY 415
Cdd:pfam06467   1 LVKATCWFCKKLIKNKPTVI-VLQNDGSVGQFCSQSCLDSY 40
ZnF_TTF super family cl02692
zinc finger in transposases and transcription factors;
563-638 3.21e-07

zinc finger in transposases and transcription factors;


The actual alignment was detected with superfamily member smart00597:

Pssm-ID: 214739  Cd Length: 91  Bit Score: 48.64  E-value: 3.21e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 218083730   563 YYTRILPNGEKTTRSWLLYSTSKDSVFCLYCKLF---GEGKNQLKNENGCKDWQHLSHILSKHEESEMHVNNSVKYSKL 638
Cdd:smart00597   1 KPRRFQKSWFHQFPDWLEYSVEKDAAFCKYCYLFrpgRDGGSDLFVTEGFCSWKKERIRLKQHEVSKRHRNARLCVNLM 79
TRASH smart00746
metallochaperone-like domain;
244-280 1.49e-04

metallochaperone-like domain;


:

Pssm-ID: 214799  Cd Length: 39  Bit Score: 39.67  E-value: 1.49e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 218083730   244 CANCKKPLQKGQTA--YQRKGSAHLFCSTTCLSSFSHKR 280
Cdd:smart00746   1 CSFCGKDIYNPGTGimVVNDGKVYYFCSSKCLSKFKKKR 39
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 334-369 6.13e-04

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


:

Pssm-ID: 428958  Cd Length: 40  Bit Score: 37.74  E-value: 6.13e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 218083730  334 NKSRCTICSKLAEIRHE---VSVNNVTHKLCSNHCFNKY 369
Cdd:pfam06467   2 VKATCWFCKKLIKNKPTvivLQNDGSVGQFCSQSCLDSY 40
 
Name Accession Description Interval E-value
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 375-415 1.41e-07

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 48.14  E-value: 1.41e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 218083730  375 LIMNCCEHCGEYMPSKSTGNnILVIGGQQKRFCCQSCINEY 415
Cdd:pfam06467   1 LVKATCWFCKKLIKNKPTVI-VLQNDGSVGQFCSQSCLDSY 40
ZnF_TTF smart00597
zinc finger in transposases and transcription factors;
563-638 3.21e-07

zinc finger in transposases and transcription factors;


Pssm-ID: 214739  Cd Length: 91  Bit Score: 48.64  E-value: 3.21e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 218083730   563 YYTRILPNGEKTTRSWLLYSTSKDSVFCLYCKLF---GEGKNQLKNENGCKDWQHLSHILSKHEESEMHVNNSVKYSKL 638
Cdd:smart00597   1 KPRRFQKSWFHQFPDWLEYSVEKDAAFCKYCYLFrpgRDGGSDLFVTEGFCSWKKERIRLKQHEVSKRHRNARLCVNLM 79
TRASH smart00746
metallochaperone-like domain;
380-419 1.57e-05

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 42.36  E-value: 1.57e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 218083730   380 CEHCGEYMPSKSTGNNiLVIGGQQKRFCCQSCINEYKQMM 419
Cdd:smart00746   1 CSFCGKDIYNPGTGIM-VVNDGKVYYFCSSKCLSKFKKKR 39
TRASH smart00746
metallochaperone-like domain;
244-280 1.49e-04

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 39.67  E-value: 1.49e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 218083730   244 CANCKKPLQKGQTA--YQRKGSAHLFCSTTCLSSFSHKR 280
Cdd:smart00746   1 CSFCGKDIYNPGTGimVVNDGKVYYFCSSKCLSKFKKKR 39
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 241-276 3.97e-04

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 38.12  E-value: 3.97e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 218083730  241 KITCANCKKPLQKGQTAY--QRKGSAHLFCSTTCLSSF 276
Cdd:pfam06467   3 KATCWFCKKLIKNKPTVIvlQNDGSVGQFCSQSCLDSY 40
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 334-369 6.13e-04

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 37.74  E-value: 6.13e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 218083730  334 NKSRCTICSKLAEIRHE---VSVNNVTHKLCSNHCFNKY 369
Cdd:pfam06467   2 VKATCWFCKKLIKNKPTvivLQNDGSVGQFCSQSCLDSY 40
 
Name Accession Description Interval E-value
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 375-415 1.41e-07

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 48.14  E-value: 1.41e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 218083730  375 LIMNCCEHCGEYMPSKSTGNnILVIGGQQKRFCCQSCINEY 415
Cdd:pfam06467   1 LVKATCWFCKKLIKNKPTVI-VLQNDGSVGQFCSQSCLDSY 40
ZnF_TTF smart00597
zinc finger in transposases and transcription factors;
563-638 3.21e-07

zinc finger in transposases and transcription factors;


Pssm-ID: 214739  Cd Length: 91  Bit Score: 48.64  E-value: 3.21e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 218083730   563 YYTRILPNGEKTTRSWLLYSTSKDSVFCLYCKLF---GEGKNQLKNENGCKDWQHLSHILSKHEESEMHVNNSVKYSKL 638
Cdd:smart00597   1 KPRRFQKSWFHQFPDWLEYSVEKDAAFCKYCYLFrpgRDGGSDLFVTEGFCSWKKERIRLKQHEVSKRHRNARLCVNLM 79
TRASH smart00746
metallochaperone-like domain;
380-419 1.57e-05

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 42.36  E-value: 1.57e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 218083730   380 CEHCGEYMPSKSTGNNiLVIGGQQKRFCCQSCINEYKQMM 419
Cdd:smart00746   1 CSFCGKDIYNPGTGIM-VVNDGKVYYFCSSKCLSKFKKKR 39
TRASH smart00746
metallochaperone-like domain;
244-280 1.49e-04

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 39.67  E-value: 1.49e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 218083730   244 CANCKKPLQKGQTA--YQRKGSAHLFCSTTCLSSFSHKR 280
Cdd:smart00746   1 CSFCGKDIYNPGTGimVVNDGKVYYFCSSKCLSKFKKKR 39
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 241-276 3.97e-04

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 38.12  E-value: 3.97e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 218083730  241 KITCANCKKPLQKGQTAY--QRKGSAHLFCSTTCLSSF 276
Cdd:pfam06467   3 KATCWFCKKLIKNKPTVIvlQNDGSVGQFCSQSCLDSY 40
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 334-369 6.13e-04

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 37.74  E-value: 6.13e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 218083730  334 NKSRCTICSKLAEIRHE---VSVNNVTHKLCSNHCFNKY 369
Cdd:pfam06467   2 VKATCWFCKKLIKNKPTvivLQNDGSVGQFCSQSCLDSY 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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